Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

Authors :: María Gabriela Echeverría
Oscar Ricardo Pardini
Nora J. François
Marta Edith Daraio
María V. Debandi
Javier Ignacio Amalvy
Source :: CIC Digital (CICBA), Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, instacron:CICBA, Repositorio Institucional Abierto (UTN), Universidad Tecnológica Nacional, instacron:UTN, Polímeros, Vol 25, Iss 4, Pp 336-343 (2015), SEDICI (UNLP), Universidad Nacional de La Plata, instacron:UNLP, Polímeros v.25 n.4 2015, Polímeros (São Carlos. Online), Associação Brasileira de Polímeros (ABPol), instacron:ABPO, Polímeros, Volume: 25, Issue: 4, Pages: 336-343, Published: AUG 2015
Publication Year :: 2015
Publisher :: FapUNIFESP (SciELO), 2015.
Abstract: A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.<br />Facultad de Ingeniería

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