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Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
- Source :
- CIC Digital (CICBA), Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, instacron:CICBA, Repositorio Institucional Abierto (UTN), Universidad Tecnológica Nacional, instacron:UTN, Polímeros, Vol 25, Iss 4, Pp 336-343 (2015), SEDICI (UNLP), Universidad Nacional de La Plata, instacron:UNLP, Polímeros v.25 n.4 2015, Polímeros (São Carlos. Online), Associação Brasileira de Polímeros (ABPol), instacron:ABPO, Polímeros, Volume: 25, Issue: 4, Pages: 336-343, Published: AUG 2015
- Publication Year :
- 2015
- Publisher :
- FapUNIFESP (SciELO), 2015.
-
Abstract
- A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.<br />Facultad de Ingeniería
- Subjects :
- Materials science
polyurethanes
stimuli-sensitive polymers
lcsh:Chemical technology
Methacrylate
drug delivery systems
swelling
chemistry.chemical_compound
Teofilina
Polymer chemistry
medicine
Chemical Engineering (miscellaneous)
lcsh:TP1-1185
Theophylline
Fourier transform infrared spectroscopy
Polyurethane
chemistry.chemical_classification
Poliuretanos
Organic Chemistry
Swelling capacity
Ciencias Químicas
Polymer
poliuretanos, sistemas de liberación de medicamentos, teofilina
theophylline
Ingeniería Química
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
Sistemas de Liberación de Medicamentos
chemistry
Drug delivery
Swelling
medicine.symptom
Nuclear chemistry
medicine.drug
Subjects
Details
- ISSN :
- 01041428
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Polímeros
- Accession number :
- edsair.doi.dedup.....37d7fb56d16d5e41ea2bcf11b36575ab