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The basic factors influencing the quality of thin films prepared by the spin-coating technique from thermosetting stoichiometric epoxy-amine mixtures have been studied. It has been shown that films 2.5–3.0 nm thick are formed on silicon supports from a 0.025 wt % solution of the stoichiometric mixture of epoxy resin and amine in toluene. Multilayer polymer coatings with thickness up to 40 nm have been prepared from successively deposited partially cured epoxy-amine layers. The thickness of these coatings grows linearly with an increase in the number of layers, while their surface energy decreases. The revealed features may be used for creating multilayer polymer coatings, the properties of which vary along the coating thickness.

The training module was developed by the staff of the department under the leadership of the head. Department of Academician of RAS, Professor I.V. Poddubnoy and Rector of FSBEI DPO RMANPO of the Ministry of Health of Russia, Corr. RAS, Professor D.A. Sychev.

This study reports the formation, structure, geometric characteristics, and conductivity of composite thin films obtained via the mobile meniscus method from nanodispersed silver particles with diameter less than 10 nm. The film thickness and the conductivity as functions of the weight concentration of a precursor (AgNO3), silver nanoparticle concentration (size), and evaporation temperature are established as well.

The article is theoretical and applied and represents the result of studying and assessing the quality of life as an integral indicator that determines the attractiveness of territories. The theoretical part of the study was built by the authors of the article on the basis of sociological understanding and economic interpretation of the category “population life quality”, on the basis of communication between the works of Russian and foreign scientists, as well as in the process of their own scientific research, the results of which are published in a series of publications and research reports. Desk research took place between 2010 and 2018. Field studies were carried out in 17 large cities of the Central Federal District of the Russian Federation in 2017 and were carried out according to criteria such as socio-economic conditions of the population, the possibility of professional, entrepreneurial, creative and other activities that increase the well-being of respondents; comfort level of life; development of social infrastructure; creation of conditions for comprehensive personal development, as well as the level of attractiveness (attractiveness) of the territory in the economic, marketing and psychological aspects. The results of the study confirmed that large cities are not only developed industrial centers, but also, for the most part, accumulate objects of education, science, culture, religion, sports, attracting tourists and providing a high standard of living for residents.

Objectives. To assess and study the effects of Cytoflavin, which is used in the complex therapy of elderly patients with alcoholism, on the dynamics of cognitive functions. Materials and methods. A prospective, randomized, parallel, cohort study was performed in 74 patients aged over 60 years with alcoholism. Results and conclusions. A statistically significant (p < 0.05) improvement in the dynamics of clinical-neurological status of the patients was obtained on the background of optimized and combined treatment including Cytoflavin, apparent as faster and more marked improvements in neuropsychological test measures than in the reference group (not treated with Cytoflavin).

The electrophoretic motion of a polyelectrolyte capsule has been considered in a uniform electric field. The capsule carries a uniformly distributed charge and is permeable to ions of different natures. An electrolyte identical to a dispersion medium is located inside the capsule. The flow in the porous layer of the capsule has been described by the Brinkman equations taking into account the effect of electrostatic forces. The distribution of ions in the vicinity of the capsule has been determined, and its electrophoretic mobility has been found in a linear approximation. The mobility of the capsule has been studied as depending on its geometric characteristics, permeability, and charge density. In particular, a complex extremal character of variations in the mobility as depending on the solid phase fraction in the capsule has been revealed at different ratios between the thicknesses of the electrical double layer and the Brinkman filtration layer.

The question of the mechanism of action and the place of application of capillary forces has been discussed. It has been shown that the conventional notions of the character of capillary forces are often contradictory. A molecular-kinetic approach has been employed to determine the places of application of capillary forces and the mechanism of their action.

To assess technical results and close functional outcomes of acute ischemic stroke (AIS) in patients treated with endovascular thrombecomy (ET) in regional vascular centers (RVC) of St-Petersburg.Retrospective analysis of 183 patients with AIS, including 143 patients with AIS due to a large intracranial vessel occlusion in anterior (AC) and 25 patients in posterior cerebral (PC) circulation, 15 with isolated extracranial carotid occlusion treated in 6 RVC in 2017 was performed. All patients underwent ET.Effective reperfusion (mTICI 2b-3) was achieved in 71.5% (71.3% AC, 72% PC). On discharge, 35,7% patients had good (mRs 0-2) functional outcome (37.1% AC, 28% PC). The incidence of symptomatic intracranial hemorrhage (according to ECASS II criteria) was 10.7% (9.1% AC, 20% PC), the mortality was 29.2% (22.4% AC, 68% PC).). The results of our study show the possibility of effective and safe application of ET in patients with AIS in the anterior and posterior cerebral circulation in regional vascular centers of St.-Petersburg.Цель исследования. Оценить технические результаты и ближайшие функциональные исходы у пациентов, подвергшихся внутрисосудистой тромбоэмболэктомии (ВСТЭ) при остром ишемическом инсульте (ИИ), в условиях региональных сосудистых центров Санкт-Петербурга. Материал и методы. Проведен ретроспективный анализ результатов лечения 183 больных в остром периоде ИИ в 6 региональных сосудистых центрах в 2017 г. У 143 пациентов имел место инсульт, вызванный окклюзией магистральной интракраниальной артерии в каротидной системе (1-я группа), у 25 - окклюзия в вертебрально-базилярной системе (2-я группа), у 15 - изолированное поражение внечерепного отдела внутренней сонной артерии. Всем пациентам выполнялась ВСТЭ. Результаты и заключение. Частота эффективной реперфузии (градация по mTICI 2b-3) составила 71,5% (71,3 и 72% в 1-й и 2-й группах соответственно). Хороший функциональный исход (0-2 балла по mRs) на момент выписки был достигнут у 35,7% пациентов (у 37,1 и 28%). Частота симптомных внутричерепных кровоизлияний (по критериям ECASS II) составила 10,7% (9,1 и 20%), летальность - 29,2% (22,4 и 68%). Таким образом, результаты исследования свидетельствуют о возможности эффективного и безопасного использования ВСТЭ у пациентов с ИИ в передних и задних отделах артериального круга большого мозга в условиях региональных сосудистых центрах мегаполиса.

Nonequilibrium processes have been considered on interfaces between media, with one medium being a permeable membrane. The nonequilibrium processes have been described in terms of nonequilibrium thermodynamics combined with the Fokker−Planck kinetic equation. Phenomenological equations derived within the framework of the combined approach have been discussed. It has been shown that the formal use of linear equations of nonequilibrium thermodynamics may be, in some cases, reduced to nonlinear equations for heat and mass transfer through an interface. It has been noted that the asymmetry of transport characteristics of asymmetric membranes may be explained in terms of the derived relations.

The mechanism for the development of osmotic pressure has been discussed. A simple method has been proposed for deriving an expression for osmotic pressure based on molecular-kinetic considerations. The invalidity of frequently used ideas of osmotic pressure as an additional contribution to the pressure of low-molecular-mass solutes, colloidal particles, or polymer molecules has been noted. It has also been indicated that, in some cases, it is more correct to speak about an osmotic reduction rather than an increase in the pressure. In particular, the Raoult law has been shown to be a direct consequence of the Van’t Hoff law for osmotic pressure.

Nonequilibrium processes occurring at interfaces between media one of which is capable of sorbing have been discussed. The entropy production accompanying the passage of a fluid from a bulk phase to the sorbing medium has been determined. It has been shown that temperature and pressure jumps must take place at the interface, which are commonly ignored when describing the transport in membrane systems. The magnitudes of these jumps upon substance transfer through the sorbing media have been determined.

Based on a retrospective analysis, to evaluate technical results and functional outcomes at discharge after endovascular thrombectomy (EVT) in anterior circulation out of 6-hours «therapeutic window» in patients with stroke.The retrospective analysis of EVT in 594 acute stroke patients (303 male, 291 female, median age 69 years) with the anterior circulation large vessel occlusion was performed. EVT was carried out before 6 hrs in 550, later in 44 patients. Time to artery puncture was defined as a cut point. Patients were included in the study if they met the criterion for 0-6 hours «therapeutic window».No significant differences in functional outcomes at discharge assessed with the Rankin scale (mRs 0-2 29.8% and 20.5%EVT in anterior circulation stroke over 6 hrs «therapeutic window» based on the criterion for 0-6 hrs provides comparable functional outcomes at discharge without the increase in the frequency of intracranial haemorrhages, haemorrhagic and symptomatic haemorrhagic transformations.На основании ретроспективного анализа изучить технические результаты и функциональные исходы на момент выписки из стационара у пациентов, подвергшихся внутрисосудистой тромбоэмболэктомии (ВСТЭ) из каротидного бассейна за пределами 6-часового окна.Проведен ретроспективный анализ результатов ВСТЭ у 594 больных (303 мужчины и 291 женщина, медиана возраста 69 лет) с окклюзией крупной интракраниальной артерии в каротидном бассейне в остром периоде ишемического инсульта в региональных сосудистых центрах Санкт-Петербурга. ВСТЭ выполнена у 550 пациентов до 6 ч, в 44 случаях — более чем через 6 ч после острого нарушения мозгового кровообращения (ОНМК) или последнего известного контакта. За точку деления групп принимали время до пункции артерии. Отбор пациентов осуществляли по критериям, установленным в пределах 6-часового «терапевтического окна».В группах пациентов, подвергшихся ВСТЭ до 6 ч и позднее, не наблюдали статистически достоверных различий по функциональным исходам на момент выписки по модифицированной шкале Рэнкин — mRs (mRs 0—2 балла — 29,8 и 20,5%, mRs 3—5 баллов — 38,7 и 38,6%, mRs 6 баллов — 31,5 и 40,9% соответственно), частоте внутричерепных кровоизлияний, геморрагических трансформаций и симптомных геморрагических трансформаций (4 и 0%, 20,9 и 29,5%, 10,1 и 11,4% соответственно).Результаты ретроспективного анализа показали, что выполнение ВСТЭ в каротидном бассейне за пределами 6-часового «терапевтического окна» по критериям отбора, применяемым в первые 6 ч от дебюта ОНМК по ишемическому типу, позволяет достичь сопоставимых функциональных исходов на момент выписки, не приводит к увеличению частоты внутричерепных кровоизлияний, геморрагических (в том числе симптомных) трансформаций очага ишемии.

The problem of a liquid flow, which is uniform at infinity, around a capsule comprising a fractal shell filled with a liquid identical to the ambient liquid has been solved. The flow in the fractal layer is described by the Brinkman equation, assuming that the viscosity of the effective medium differs from the viscosity of the pure liquid. Velocity and pressure distributions have been found, and the viscous drag force applied to the capsule has been calculated.

The problem of local entropy production in gases flowing through nanosized channels has been discussed. The main attention has been focused on the role of adsorbed layers. It has been shown that the local entropy production differs from that obtained in terms of the classical approach. For example, the transfer in the adsorbed layer influences both the entropy production and the form of phenomenological equations. An additional difference results from the mass and energy exchange between the bulk phase and the adsorbed layer, this exchange being related to nonlinear adsorption isotherms. This exchange is described by independent local phenomenological equations.

The problem of a liquid flow that is uniform at infinity around a capsule containing a fractal aggregate is solved. The flow in the porous layer of the capsule is described by the Brinkman equation, assuming that the viscosity of the Brinkman medium differs from the viscosity of the pure liquid. The tangential stress jump condition is imposed on the liquid-porous medium interface. Velocity and pressure distributions are found, and the hydrodynamic force applied to the capsule is calculated.

The methods of nonequilibrium thermodynamics are used to describe the temperature gradientinduced motion of inclusions and the cross effect in solids occurring in the state of premelting. Inclusion motion is caused by a nonuniform disjoining pressure in thin unfrozen interlayers that are formed at a nonuniformly heated inclusion. The cross effect is related to the generation of a local temperature field upon the inclusion motion under the action of an external force in a uniform solid. It is shown that the Onsager relations are valid for the nonequilibrium processes under consideration.

The problem of the infinite uniform flow of liquid around the spherical drop coated with the porous layer is solved. External liquid permeates into the porous layer but is not mixed with the liquid located in the internal cavity of a capsule. The flow inside the porous layer is described by the Brinkman equation; moreover, the viscosity of the Brinkman medium is assumed to be different than the viscosity of pure liquid. The boundary condition of the jump of tangential stresses at the liquid-porous medium interface is used. Velocity and pressure distributions are found and the hydrodynamic force acting on the capsule is calculated. Different limiting cases are considered.

The flow of viscous liquid in a porous model medium with a fractal structure is considered. The hydrodynamic permeability of a medium is calculated according to the Happel and Brenner cell method using Brinkman equations. An analysis is carried out for boundary conditions on the cell surfaces of four types corresponding to the Happel, Kuwabara, Kvashnin, and Cunningham models. Situations that correspond to the flow of viscous liquid in a porous medium formed by fractal aggregates and the uniform flow of viscous liquid around the single composite particle are analyzed.

The problem of a liquid flow that is uniform at infinity around a spherical porous capsule is solved. The flow in a porous layer is described by the Brinkman equation assuming that the viscosity of the Brinkman medium differs from the viscosity of the liquid flowing around. The tangential stress jump condition is imposed on the porous medium-liquid interface. Velocity and pressure distributions are determined and the hydrodynamic force applied to the capsule is calculated.

An analytical expression has been derived to calculate the temperature in the bulk of a piezoelectric cell and on its surface with allowance made for the distributed heat release. It is experimentally shown that the temperature at the center of actuator exceeds the temperature on its surface by 10–40°C and reaches 50–140°C under specific loads of 50–100 W/cm3. The reason for this is that up to 25–45% of the supplied energy is transformed into heat. It is established that the main cause of actuator failure is electric breakdown and exfoliation of passive ceramic layers.

The laboratory biomarkers can effect on choice of tactics of treatment in patients with atherosclerotic stenosis ofcarotids and high risk of stroke. However, nowadays there is no established laboratory criteria of significant atherosclerotic affection of internal carotid. The purpose of study was to investigate informativeness of biomarkers of atherosclerosis in clinical molecuIar panel of expertise system of determining risk of stroke in patients with significant stenosis of carotid. The study included patients with 50-90% atherosclerotic stenosis of internal carotid in acute period of atherothrombotic stroke or transitory ischemic attack (group 1), patients with stable 50-90% atherosclerotic stenosis of inner carotid having no vascular events during 30 days before engaging into study (group II) and group of healthy volunteers without atherosclerosis of inner carotid. The examination of patients included anamnesis collection, evaluation of neurological status, analysis of serum level of biomarkers of atherosclerosis (lipoprotein-associatedphospholipase A2 (LP-PL A2), serum protein A associated with pregnancy (PA PP-A), lipoprotein (a) (LP(a)), asymmetric dimethylarginine (ADMA), C-reactive protein detected by highly sensitive technique (hsCRP) and lipid spectrum of blood) using enzyme-linked immunosorbent assay, duplex ultrasound scanning of brachiocephalic arteries. The stroke risk factors of other etiology were chosen as exclusion criteria except atherothrombotic one. The Mann-Whitney and Kruskal-Wallis tests were applied to establish group differences. The Data Mining techniques were applied to establish patterns of analyzing sample. Out of 356 examined patients, 30 patients of group 1, 51 patients of group II and 16 healthy volunteers were included in the study. All patients were comparable by gender and age (50-80 years). The serum level of hsCRP and ADMA in the group of patients of acutest period of ischemic stroke was significantly higher than in groups of patients with stable stenosis and healthy volunteers (p0.05). The comparison between three groups established no statistically significant differences in serum concentration of PAPP-A, LP-PL A2 and LP(a). The ADMA, hsCRP and PAPP-A can be recommended for including into clinical molecular panel for personalized diagnostic of causes of stroke along with clinical anamnestic data. The serum level of ADMA and hsCRP significantly increases in acute period of atherothrombotic stroke. The analysis of levels of ADMA, hsCR and PPAPP-A interpreted with regard to clinical anamnestic data can be proposed for enhancing quality of diagnostic of causes of stroke.

The influence of tungstic acid on oxide film growth during indium phosphide thermal oxidation is studied. When H2WO4 is added to the reaction zone, tungsten is captured by growing layers and heteropoly compounds are formed.

An experiment is conducted to investigate the influence of tungstic acid, H2WO4, on the growth mechanism of thermal-oxide thin films on GaAs. It is established that feeding H2WO4 into the reaction zone leads to incorporation of W into the oxide and formation of heteropoly compounds.

Adsorption of cationic (dodecylpyridinium bromide) and nonionic (Triton X-100) surfactants from their mixed aqueous solutions on a SiO2 surface at pH 3.6, 6.5, and 10 is studied by the UV spectroscopy, capillary zone electrophoresis, and wetting measurements. It is shown that the adsorption of cationic and nonionic surfactants from mixed solutions is accompanied by synergistic effects manifesting themselves as an enhanced adsorption of both surfactants compared to their adsorption from individual solutions. The effect of second component becomes most pronounced under conditions when differences in adsorption abilities of individual surfactants are rather large (at pH 3.6 and 10). It is shown that the adsorption of surfactants from mixed solutions can be controlled by the adsorption ability of components via the variations in solution pH.

Несмотря на существование в настоящее время четкой концепции о фоновых и предраковых процессах и раке шейки матки (РШМ), а также достаточно надежного тестового контроля (цитологический, кольпоскопический), РШМ до настоящего времени остается одной из актуальных проблем онкогинекологии. Достигнутые на сегодняшний день достаточно высокие показатели выживаемости больных распространенным РШМ все же нельзя признать удовлетворительными. Это диктует необходимость проведения разноплановых исследований, имеющих цель увеличить продолжительность жизни этойкатегории больных. Заслуживающими пристального внимания являются методы радиомодифицирующего воздействия лекарственных препаратов.

Занимая по заболеваемости 3 место среди онкогинекологической патологии, рак яичников является ведущей причиной смерти у онкогинекологических больных.Лечение распространенного рака яичников в целом включает циторедуктивную операцию, химиотерапию, иммунотерапию и лучевое лечение.Таксаны (доцетаксел и паклитаксел) нашли довольно широкое использование при раке яичников.С мая 1998 по август 2001 г. в 8 онкологических учреждениях Российской Федерации проведено многоцентровое нерандомизированное изучение эффективности комбинации таксотера с цисплатином у больных распространенным раком яичников. В исследовании приняли участие 3 центра в Москве: РОНЦ им. Н.Н.Блохина РАМН, НИОИ им. П.А.Герцена, Городская клиническая больница №40, а также онкологические центры в Барнауле, Ростове-на-Дону и онкологические диспансеры в Кирове, Краснодаре и Волгограде. С целью однотипного отбора больных в различных лечебных учреждениях исследование осуществляли по единому протоколу. Анализ полученных данных подтверждает предварительное мнение, что доцетаксел/карбоплатин является возможной альтернативой схемы паклитаксел/карбоплатин в качестве I линии химиотерапии при раке яичников.

Dependences of the surface tension of aqueous solutions of cationic (dodecylpyridinium bromide) and nonionic (Tween 80, Triton X-100) surfactants and their mixtures on total surfactant concentration and solution composition were studied. The values of critical micellization concentration (CMC) and excess free energy of adsorption were determined from tensiometric measurements. Based on Rubingh–Rosen model (approximation of the theory of regular solutions), the compositions of micelles and adsorption layers at the solution–air interface as well as parameters of interaction between the molecules of cationic and nonionic surfactants were calculated for the systems indicated above. It was established that, in the case of surfactant mixtures with considerable difference in the CMCs, the micelles of individual surfactant with lower CMC value are formed. The effect of negative deviation from the ideality during the adsorption of surfactants from mixed solutions at the solution–air interface was disclosed. It was shown that the interaction energy depends significantly on the composition of mixed systems.

The micellization of the mixtures of cationic (cetyltrimethylammonium bromide, cetylpyridinium bromide) and nonionic (Triton X-100) surfactants at various content of components in aqueous solutions, as well as the adsorption of surfactants at the air/solution interface were studied. The effect of negative deviation from the ideality was discovered during the formation of mixed micelles and adsorption layers. Various theoretical approaches to the quantitative description of mixed systems were compared within the framework of the model of pseudophase separation. The parameters of intermolecular interaction in mixed micelles and adsorption layers, excess free energies of micellization and adsorption, compositions of micelles and adsorption layers were calculated. It was shown that the use of various theoretical approaches for the analysis of interactions in surfactant mixtures leads to close numerical results. It was shown that the composition of mixed micelles and adsorption layers, as well as the parameters of intermolecular interaction and the excess free energy depend on the relative content and molecular structure of surfactants (mixture components).

The article presents the results of prospective longitudinal study. The aim of the study was to investigate influence of complex therapy with chondroitin sulfate on pain and functional disorders in elderly patients with knee osteoarthritis. The study shows sufficient decreasing of pain, stiffness and functional disorders with complex therapy with chondroitin sulfate in comparison with nonsteroidal anti-inflammatory drugs (NSAID) by the second month of therapy with stable effect the next 2 months. All patients decrease their NSAID intake by the end of the study. Satisfaction of complex therapy was high according to patient's and physician's opinion.

Рак яичников является ведущей причиной смерти у онкогинекологических больных.В настоящее время изучено около 2 десятков новых противоопухолевых агентов, проявивших достаточно высокую активность при лечении резистентных форм распространенного рака яичников в качестве второй линии.Гемзар как моноагент зарекомендовал себя активным препаратом второй и третьей линий лечения распространенного рака яичников и его рецидивов в неблагоприятных клинических ситуациях - при наличии резистентности к цисплатину и паклитакселу, которые использовались в первой линии лечения.Наилучшие результаты получены при сочетании гемзара с цис/карбоплатином и/или паклитакселом. Благодаря благоприятному профилю токсичности препарат хорошо переносился больными, ранее леченными препаратами платины и паклитакселом, что дает возможность его использования у больных пожилого возраста (старше 60 лет).

В последние десятилетия отмечено значительное увеличение заболеваемости раком тела матки (РТМ): с 1970 по 1995 г. заболеваемость раком эндометрия (РЭ) увеличилась на 55%, занимая 1-е место среди злокачественных опухолей женской половой сферы. Анализируя результаты терапии РЭ, следует сказать, что при комбинированном или комплексном лечении с выполнением хирургического вмешательства выживаемость больных на 20% выше, чем при использовании сочетанной лучевой терапии.Проведение адекватного хирургического, лучевого и химиогормонального лечения позволяет улучшить показатели 5-летней выживаемости при I стадии до 85%, II стадии до 75%, III стадии до 56%.

Эпидемиологические исследования показывают, что в последнее время отмечается тенденция роста заболеваемости злокачественными опухолями яичников. Целью нашего исследования являлось изучение влияния клинико-морфологических факторов на возникновение рецидивов РЯ I-IIА стадии и на отдаленные результаты лечения. В основу исследования положен анализ клинико-морфологических данных обследования и лечения 282 больных, страдающих РЯ I-IIА стадии, оперированных в гинекологических стационарах общего профиля, а также проходивших лечение в РОНЦ им. Н.Н.Блохина РАМН с 1971 по 2001 г. Средний возраст больных составил 50,5 года (от 16 до 76 лет). Из 282 пациенток у 94 (33,3%) развился рецидив заболевания в сроки от 3 мес до 16,5 года. По предварительным данным нашего исследования, достоверно значимыми благоприятными прогностическими факторами являются: молодой возраст больных (до 40 лет), минимальная степень распространенности опухолевого процесса (IA стадия), муцинозный гистологический тип опухоли, высокая и умеренная степени дифференцировки. Ухудшают прогноз заболевания светлоклеточный гистологический тип опухоли, низкая степень дифференцировки опухолевых клеток и такие неблагоприятные клинические факторы, как острое начало заболевания, разрыв капсулы опухоли и наличие сращений ее с окружающими органами и тканями.

To find clinical criteria applied in the first hours of disease for the identification of severe ischemic stroke caused by an occlusion of proximal major arteries.The authors have analyzed 133 medical histories of patients with the diagnosis of acute cerebral blood circulation disorder admitted in the first 6 h from onset. All patients underwent CT-angiography or digital subtraction angiography. Occlusion of the inner carotid artery, occlusion of M1-segment of the middle cerebral artery and occlusion of a major artery were considered as proximal occlusion of major cerebral arteries. Neurological status was assessed by the signs of proximal arterial occlusion (PAO).Checking of 5 PAO symptoms allows the prediction of occlusion location in approximately 80% of cases. Presence of ≥3 out of 5 symptoms is characterized by 70% sensitivity and 90% specificity with regard to the occlusion of the inner carotid artery, M1-segment of the middle cerebral artery and/or a major artery. Predictive value of this model should be verified in a prospective study.Цель исследования. Bыявить клинические критерии для идентификации тяжелого ишемического инсульта, вызванного окклюзией проксимальных отделов магистральных артерий, применимые в первые часы от дебюта заболевания. Материал и методы. Проанализировано 133 истории болезни пациентов с диагнозом ОНМК, поступивших в течение 6 ч от дебюта инсульта, которым при поступлении была выполнена КТ-ангиография либо цифровая субтракционная ангиография. Проксимальной окклюзией магистральных церебральных артерий считали окклюзию внутренней сонной артерии на всем протяжении, окклюзию М1-сегмента средней мозговой артерии и окклюзию основной артерии любой локализации. Для оценки неврологического статуса оценивали признаки проксимальной артериальной окклюзии (ПАО). Результаты и заключение. Показано, что проверка 5 симптомов ПАО позволяет правильно предположить локализацию окклюзии почти в 80% случаев ишемического инсульта. Наличие 3 и более из 5 перечисленных неврологических симптомов характеризуется 70% чувствительностью и 90% специфичностью в отношении окклюзии внутренней сонной артерии, М1-сегмента средней мозговой артерии и/или основной артерии. Предсказательную способность данной модели следует верифицировать в проспективном исследовании.

13 cases of uterine carcinosarcomas have been studied by molecular-genetic method. The impairment of some genes (K-RAS gene in the first exon, TP53 in the 5th-9th exons, PTEN in the 5th and 8th exons) has been found out. The loss of heterozygosity of TP53 gene in epithelium and mesenchyme of the uterus has been detected. According to the estimation of impairment the studied tumors was divided into monoclonal and biclonal ones. This stratification could be use as prognostic criteria of uterine carcinosarcomas clinical presentation.

Clinico-morphological and immunohistochemical examinations were carried out in 46 patients with carcinocarcinoma of the corpus uteri to evaluate p53, PTEN and cyclooxygenase-2 (COX-2) expression in mesenchymal and epithelial cells of tumor. p53 expression in the epithelium and that of COX-2 in both compartments appeared to be unfavorable prognosticators of survival while that of PTEN is a lesser one in significance.

Results of clinico-morphological and immunohistochemical studies of 44 cases of carcinosarcoma of the uterus are presented in an attempt to provide pathogenetic rationale for prognosticators of the disease. Immunohistochemical reactions were used to evaluate the expression of genes and mediators p53 and PTEN and cyclooxigenase (COX-2) in cells of mesenchyme and epithelium of tumor to gauge the influence of either component on its biological behavior. All patients were divided into two groups depending on whether they revealed expression of p53, PTEN and cyclooxigenase or not. The end results--overall survival and complete remission duration--were compared in both groups. No dominance of either component of carcinosarcoma was established.

Arterial hypertension contributes essentially into development of chronic heart failure and chronic ischemia of the brain, which results in social dependence of geriatric patients. One of the important factors in the development of arterial hypertension is the state of lipids peroxidation. Misbalance among the products of lipids peroxidation and components of antioxidation defense system revealed in cardiovascular diseases (mainly in arterial hypertension and heart failure) promotes progress of these diseases and premature aging of an organism. The therapy aimed at normalization of the oxidative profile of the patients with arterial hypertension should include prolonged beta-blockers, ACE inhibitors, calcium antagonists, statines and polyvitamin complexes with vitamins A and E.

The results of gamma-ray burst observations made in the 10 keV - 8 MeV range with Konus-B instrument on Granat spacecraft are presented. 19 gamma-ray bursts and 60 solar flares have been measured altogether in 27 days at a sensitivity level of 5×10−8 - 5×10−7 erg/cm2. The fast spectral variability of bursts and the presence of features in their spectra in the form of absorption and emission lines are confirmed.

Surfactant mixtures are commonly used in many industrial applications. At the same time, the methods for surfactant analysis are rather laborious and often do not permit the determination of the individual surfactant content in mixed solutions. In the present work capillary zone electrophoresis (CZE) instrumentation was applied for the quantitative analysis of a cationic surfactant (dodecylpyridinium bromide) and a nonionic surfactant (Triton X-100) in aqueous solutions. The linear dependence of the analytical signal (electrophoregram peak area) versus the surfactant concentration was established for both surfactants over a wide concentration range. The analytical signal of an individual surfactant was found to be independent of the addition of the second surface-active component, making it possible to determine the content of surfactants from both solutions of individual surfactants and mixed solutions. The CZE method was shown to be appropriate for the determination of critical micelle concentrations as the intersection point of two straight lines describing the dependence of analytical signal versus surfactant concentration below and above the critical micelle concentration.

The paper covers the problems of diagnosis of germinogenic ovarian tumors in girls, which make up as high as 80% of all malignant ovarian tumors. For timely diagnosis, it is necessary to take into account clinical data, the levels of tumor markers (alpha-fetoprotein, chorionic gonadotropin) and ultrasound findings. This all is rather sufficient to verify the diagnosis of ovarian tumor lesions. Other additional studies are aimed at establishing where the process extends.

Занимая 3-е место по заболеваемости среди злокачественных опухолей женских половых органов, рак яичников (РЯ) является ведущей причиной смерти у онкогинекологических больных.