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6. P-80 A multicenter randomized phase II study comparing CAPOXIRI plus bevacizumab and FOLFOXIRI plus bevacizumab as the first-line treatment for metastatic colorectal cancer: A safety analysis of the QUATTRO-II study

Author

T. Masuishi, H. Bando, H. Satake, D. Kotani, T. Hamaguchi, M. Shiozawa, T. Ikumoto, Y. Kagawa, H. Yasui, T. Moriwaki, H. Kawakami, S. Boku, E. Oki, Y. Komatsu, H. Taniguchi, K. Muro, M. Kotaka, K. Yamazaki, T. Misumi, T. Yoshino, T. Kato, and A. Tsuji

Subjects
Oncology, Hematology
Published
2022
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10. Extent of self-adjustment to AF in exercise capacity evaluates significance of sinus maintenance and determines suitability of sinus maintenance therapy in patients with persistent AF

Author

T Hamaguchi, Tetsuya Haruna, Moriaki Inoko, T Kuriyama, E. Nakane, and Y Yamaji

Subjects
medicine.medical_specialty, business.industry, Atrial fibrillation, Exercise capacity, medicine.disease, medicine.anatomical_structure, Maintenance therapy, Internal medicine, Heart failure, Cardiology, medicine, Self adjustment, Sinus rhythm, In patient, Cardiology and Cardiovascular Medicine, business, Sinus (anatomy)
Abstract

Atrial fibrillation (AF) causes hemodynamic inefficiency and possibly deteriorates to heart failure (HF). However, we have experienced drastic variances in the extent of HF deterioration in persistent AF (PeAF) patients. Some studies showed that newly developed PeAF (New AF), not preexisting PeAF adversely impacted HF patients in two years. These issues suggest that most PeAF patients gradually adjust to AF-induced hemodynamic inefficiency, however the extent of self-adjustment to PeAF differs among patients. We hypothesized that the extent of the self-adjustment might determine the adverse impact of New AF on patients. We proposed that especially New AF patients with poor adjustment to PeAF should be targeted for aggressive sinus rhythm (SR) maintenance through catheter ablation (RFCA). We considered exercise capacity (EC) of PeAF patients as the extent of the self-adjustment to PeAF. Consequently, we sought to investigate whether EC testing (CPX) in PeAF patients could be used as a determinant for suitability of aggressive SR maintenance therapy in PeAF patients. Subjects & Method: We performed CPX to evaluate Peak VO2 intake (PVO2) at baseline for 196 consecutive PeAF patients undergoing RFCA (male: 151, female: 45). After >6 months SR-maintenance, CPX was repeated. %PVO was calculated by standardizing PVO to age and gender. During RFCA, Swan-Ganz catheter study was done to monitor changes in hemodynamics before and after RFCA. Echocardiography was done at baseline, 6 months after SR maintenance. Results %PVO varied from 38 to 175% before RFCA. %POV2 of NYHA 3 class patients was 76.8±17.7%. PeAF patients with 80% and more of %PVO2 seemed adjusted to AF in terms of exercise capacity. In this study we defined PeAF patients below 80% PVO2 as Non-adjusted. Out of 196 patients, 149 undertook CPX again. Changes in %PVO2 ranged from −38% to 48% (median: 7.0%). According to multi-regression analysis of changes in %PVO, PeAF patients with Non-adjustment (β=0.31), greater increase in HR during repeated CPX (β=0.40), larger reduction in E/e (β=−0.21) after SR maintenance, obtained larger improvement in EC. Particularly, Non-AF adjustment in PeAF patients was the sole predictor of improvement in EC after RFCA. Furthermore, we sought to identify the determinants of Non-AF adjustment in PeAF patients. Multivariate logistic analysis demonstrated that female patients became Non-adjusted significantly more easily than male (p Conclusion The extent to which PeAF patients could adjust to AF helps in evaluating the significance of SR-maintenance and determining the suitability of aggressive SR-maintenance therapy. Funding Acknowledgement Type of funding source: None

Published
2020
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11. P924Prognostic significance of moderate primary mitral regurgitation and atrial fibrillation

Author

T Kuriyama, Y Abe, T Hamaguchi, Moriaki Inoko, X Mu, and H Hayashi

Subjects
Mitral regurgitation, medicine.medical_specialty, business.industry, Heart failure, Internal medicine, Composite outcomes, medicine, Cardiology, Echocardiography transthoracic, Atrial fibrillation, Cardiology and Cardiovascular Medicine, medicine.disease, business
Abstract

Background Severe primary mitral regurgitation [degenerativeMR (DMR)] is associated with poor outcome, including cardiac death and admission due to worsening heart failure. Whereas little information is available regarding the characteristics of moderate DMR and their impact on prognostic outcome. The aim of the present study was to investigate the prognosis and its determinant in patients with moderate DMR. Methods From 13,700 consecutive patients who underwent transthoracic echocardiography. We selected moderate DMR but without other underlying cardiac diseases. Characteristics and event free rate as compared with age- and gender-matched patients with none to mild MR. Results Of a total of our cohort, 185 (1%) patients had moderate DMR, and we compared with 185 age- and gender-matched patients with none to mild MR. During the follow-up period of 1372±655 days, 30 patients (8%) met the composite endpoint defined as cardiac death and admission due to worsening heart failure. Kaplan-Meier analysis showed patients with moderate DMR was significantly associated with a poor outcome compared to patients with none to mild MR (log-ranktest P Prgnostic outcome: AF and moderate DMR Conclusions Patients withmoderate DMR and concomitant AF had a significant poor outcome. An activesurveillance and some intervention for AF and moderate MR may be required.

Published
2019
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13. Erfahrungen bei peripheren Osteosynthesen mit monokristallinen Alumina-Keramik-Schrauben*

Author

A. Inoue, H. Oonishi, T. Shikita, and T. Hamaguchi

Subjects
medicine.medical_specialty, Osteosynthesis, Materials science, Alumina ceramic, medicine, Sapphire, Orthopedics and Sports Medicine, Surgery, Composite material, Bone cement
Abstract

As a new kind of material for peripheral osteosynthesis we have developed the single crystal alumina ceramics screws (artificial sapphire screws) taking under consideration of the properties of alumina ceramics, and we have tested them experimentally in animals, and used them clinically too. The results of the mechanical tests and animal experiments were excellent. In the clinical follow-up studies the perfect bone unions has been recognized roentgenologically. The sapphire screws have, sofar, proved to be harmless also as anchor for bone cement. Our experience with our sapphire screws has opened the way for the clinical application of this material instead of metal screws.

Published
2008
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14. Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage

Author

Kazuyuki Omae, Miyuki Hirata, Tatsuya Chonan, Toru Takebayashi, O. Taguchi, T. Hamaguchi, Yuriko Kikuchi, Noriyuki Yoshioka, Yuji Nishiwaki, and Akiyo Tanaka

Subjects
Adult, Male, Spirometry, Conservation of Natural Resources, medicine.medical_specialty, Pathology, Phosphines, chemistry.chemical_element, Indium, Gastroenterology, chemistry.chemical_compound, Japan, Occupational Exposure, Internal medicine, medicine, Humans, Respiratory system, Lung, Aged, Dose-Response Relationship, Drug, medicine.diagnostic_test, Rapid expansion, business.industry, Smoking, Public Health, Environmental and Occupational Health, Dust, Middle Aged, respiratory system, Occupational Diseases, Cross-Sectional Studies, medicine.anatomical_structure, Solubility, chemistry, Indium phosphide, Compound semiconductor, Indium arsenide, Lung Diseases, Interstitial, Tomography, X-Ray Computed, business
Abstract

Objectives: To identify the effects of indium on the lung and to assess exposure-effect and exposure-response relations between indium exposure and effects on the lungs. Methods: Ninety three male indium exposed and 93 male non-exposed workers from four ITO manufacturing or ITO recycling plants were analysed in a cross-sectional study. Indium in serum (In-S) was determined as a biological exposure index. Geometric means (GSD) of In-S were 8.25 ng/ml (4.55) in the exposed workers and 0.25 (2.64) in the non-exposed workers. The maximum concentration of In-S was 116.9 ng/ml. A questionnaire for respiratory symptoms and job histories, spirometry, high-resolution computerised tomography (HRCT) of the chest, serum KL-6, serum SP-A, serum SP-D and serum CRP were measured as the effect indices. Results: Spirometry, subjective symptoms and the prevalence of interstitial or emphysematous changes on lung HRCT showed no differences between exposed and non-exposed workers. Geometric means (GSD) of KL-6, SP-D and SP-A in the exposed workers were 495.4 U/ml (2.26), 85.2 ng/ml (2.02) and 39.6 ng/ml (1.57), and were significantly higher than those in the non-exposed workers. The prevalence (%) of the exposed and nonexposed workers exceeding the reference values were also significantly higher in KL-6 (41.9 vs 2.2), SP-D (39.8 vs 7.5), and SP-A (43.0 vs 24.7). Very sharp exposureeffect and exposure-response relations were discovered between In-S and KL-6 and between In-S and SP-D when the exposed workers were classified into seven groups by In-S. Conclusions: The study outcomes with regard to the basis of serum immunochemistry biomarkers and HRCT indicate that exposure to hardly soluble indium compound dust may represent a risk for interstitial lung damage. Since the rapid expansion of compound semiconductors and liquid crystal display (LCD) production, the consumption of indium has been increasing. Beginning in the mid-1990s, the authors’ institutions performed single or repeated intratracheal instillation experiments with fine particles of hardly soluble indium compounds such as indium phosphide (InP) and indium arsenide and found that these induce severe lung inflammation with fibrotic changes 1–6 and have mild reproductive

Published
2008
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15. Servo Signal Quality for Perpendicular Recording in Servo Write Process

Author

Kyo Akagi, S. Nishida, and T. Hamaguchi

Subjects
Key point, Quality (physics), Computer science, Acoustics, Process (computing), Perpendicular recording, Electrical and Electronic Engineering, Servo, Magnetic flux, Electronic, Optical and Magnetic Materials, Magnetic switching
Abstract

In servo-writing with perpendicular recording, we have clarified that quality deterioration of the servo signal occurs in specific magnetized media. The key point is that the flux flows through the writer to the reader. For this study, we specifically investigated servo-write quality and servo performance and found that the erasing conditions strongly affected the servo-write quality, especially in the reading process.

Published
2007
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16. Polymorphisms of norepinephrine transporter and adrenergic receptor α1D are associated with the response to β-blockers in dilated cardiomyopathy

Author

Hiroshi Okamoto, Akira Kitabatake, Junichi Yoshikawa, Yasushi Fujio, Minoru Yoshiyama, Junichi Azuma, Yasuhiko Takemoto, T Hamaguchi, Shinpei Nonen, and Yutaka Matsui

Subjects
Cardiomyopathy, Dilated, Male, medicine.medical_specialty, Genotype, Adrenergic receptor, Adrenergic beta-Antagonists, Adrenergic, Receptors, Adrenergic, alpha-1, Internal medicine, Idiopathic dilated cardiomyopathy, Genetics, medicine, Humans, Alpha-1D adrenergic receptor, Aged, Pharmacology, Norepinephrine Plasma Membrane Transport Proteins, Polymorphism, Genetic, biology, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Dilated cardiomyopathy, Middle Aged, medicine.disease, Endocrinology, Norepinephrine transporter, Heart failure, Cardiology, biology.protein, Molecular Medicine, Female, business
Abstract

Recent clinical trials have clearly demonstrated that the administration with beta-blockers decreases the mortality in the patients with chronic heart failure (CHF). However, significant heterogeneity exists in the effectiveness of beta-blockers among individual cases. We focused on 39 polymorphisms in 16 genes related to adrenergic system and investigated their association with the response to beta-blockers among 80 patients with CHF owing to idiopathic dilated cardiomyopathy. The polymorphisms of NET T-182C (P=0.019), ADRA1D T1848A (P=0.023) and ADRA1D A1905G (P=0.029) were associated with the improvement of left ventricular fractional shortening (LVFS) by beta-blockers. Furthermore, combined genotype analysis of NET T-182C and ADRA1D T1848A revealed a significant difference in LVFS improvement among genotype groups (P=0.011). These results suggest that NET (T-182C) and ADRA1D (T1848A and A1905G) polymorphisms are predictive markers of the response to beta-blockers. Genotyping of these polymorphisms may provide clinical insights into an individual difference in the response to the beta-blocker therapy in CHF.

Published
2007
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17. Perpendicular Magnetic Recording Integration and Robust Design

Author

T. Matsui, Roger Wood, T. Hamaguchi, and M. Mochizuki

Subjects
Physics, business.industry, Demagnetizing field, Magnetic flux, Electronic, Optical and Magnetic Materials, Magnetic field, Transducer, Optics, Robustness (computer science), Perpendicular, Erasure, External field, Electrical and Electronic Engineering, business
Abstract

We have investigated the effects of stray magnetic field upon a perpendicular magnetic recording (PMR) system, which consists of a single pole type head and a double-layered perpendicular medium. We found that fields in the plane of the disk could cause serious erasure. External magnetic flux concentrates around the edges of a return pole and can cause very large fields to appear in the medium. In addition, the writing operation significantly enhances this erasure. We called this kind of erasure "corner erasure." Experimental 2.5-inch hard disk drives (HDDs) were used to study the combined effect of the external field and write field. We checked SER degradation after applying an in-plane field of 0.8 kA/m (10 Oe). With no write-current applied, there is no degradation. However, as little as 0.8 kA/m (10 Oe) applied during writing causes severe degradation equivalent to that produced by a 4.0 kA/m (50 Oe) field applied when the head is reading on-track. It is concluded that the realization of PMR in commercial HDD would require new transducer designs to solve these problems. We devised a new return pole design which has a stepped-back wing to improve the robustness against in-plane stray fields. The alternative design greatly reduces the concentration of magnetic flux at the edges of return pole. Consequently, the stepped wing structure achieves about twice the robustness of the conventional rectangular return pole. A method was developed to allow external field sensitivity to be carefully checked. The method allows the degraded areas of data to be associated with the exact feature on the head that caused the problem

Published
2007
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20. A design method ? based on a shock-response-spectrum analysis ? for reducing acoustic noise of a seeking control system in a hard disk drive

Author

K. Shishida, Atsushi Okuyama, T. Horiguchi, T. Hamaguchi, Y. Nishimura, and Keiko Watanabe

Subjects
Engineering, Control synthesis, business.industry, Control engineering, Active systems, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Noise, Hardware and Architecture, Shock response spectrum, Control theory, Control system, Noise control, Electrical and Electronic Engineering, Design methods, business
Abstract

A design methodology for reducing seeking noise in a hard disk drive has been developed. This method can optimize the seeking current according to a shock-response-spectrum analysis. It was verified experimentally that this method can reduce the seeking noise by about 4 dBA on average without increasing the seeking time.

Published
2003
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21. A mobile storage device with the magneto-optical disk of a 50 mm diameter and 730 MB capacity

Author

T. Hamaguchi, S. Takahashi, A. Yamada, M. Takuma, and T. Hisamitsu

Subjects
business.industry, Computer science, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Tracking (particle physics), Magnetic field, Magneto optical, Optics, Computer data storage, Data_FILES, Media Technology, Electrical and Electronic Engineering, business, Optical disc, Computer hardware
Abstract

A small re-writable optical disk has been proposed. The media, which is called "iD PHOTO" disk, has a diameter of 50 mm and 730 MB capacity. We developed a new storage device with the iD PHOTO disk. In this paper we describe this storage device and the techniques used to realize the iD PHOTO system.

Published
2002
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22. Multiple sclerosis and alopecia areata

Author

T. Kazuya, Y. Tada, T. Hamaguchi, Masahito Yamada, and Yoshihisa Ikeda

Subjects
medicine.medical_specialty, business.industry, Multiple sclerosis, Alopecia areata, medicine.disease, Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Neurology, 030220 oncology & carcinogenesis, medicine, Neurology (clinical), business
Published
2017
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23. Perpendicular Head Structures to Improve the Corner Erasure Robustness

Author

T. Okada, Youji Maruyama, T. Hamaguchi, Roger Wood, Yimin Hsu, and M. Mochizuki

Subjects
Physics, business.industry, Data erasure, Shields, Perpendicular recording, Magnetic flux, Electronic, Optical and Magnetic Materials, Magnetic field, Optics, Robustness (computer science), Perpendicular, Erasure, Electrical and Electronic Engineering, business
Abstract

Data erasure can arise when a hard disk drive is exposed to a large external magnetic field. This has been raised as a particular concern for drives employing perpendicular recording. Flux tends to concentrate between the head and the soft-underlayer of the disk, especially around the edges and corners of the head where the data erasure is often most pronounced. In this paper, we use 3-D finite-element modeling to investigate the effects of head geometry on the fields that cause data erasure. An in-plane external field causes concentration of magnetic flux at the edges of the return pole (RP) and the upper and lower shields of the reader (USL/LSL). We found increasing the length (downtrack) of these structures is effective in reducing the erasure fields. Aligning the edges of the RP, USL, and LSL is also shown to be a practicable and effective way to reducing the erasure fields. These erasure fields are aggravated when the write element is active. The fields that arise during writing must be taken into consideration when assessing data erasure

Published
2007
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25. An alternating DC track servo pattern for perpendicular recording

Author

K. Shishida, T. Hamaguchi, K. Usui, and H. Maeda

Subjects
Physics, Nuclear magnetic resonance, Amplitude, Noise (signal processing), Acoustics, Servo bandwidth, Track (disk drive), Servo control, Perpendicular recording, Electrical and Electronic Engineering, Signal, Servo, Electronic, Optical and Magnetic Materials
Abstract

We describe an alternating dc track servo pattern as a way to avoid magnetization imbalances within the position error signal (PES) regions of the media in perpendicular recording systems. A spin-stand was used to compare signal amplitude and medium noise between the alternating dc track servo pattern and a conventional dc-track servo pattern. The alternating dc track servo pattern improves the signal amplitude and decreases the residual noise. Therefore, the new servo pattern exhibits a superior signal-to-noise ratio of the PES regions.

Published
2005
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26. Advanced DC-free track code pattern using diphase code for perpendicular recording

Author

H. Maeda, T. Hamaguchi, and K. Shishida

Subjects
Computer science, Track (disk drive), Acoustics, Code (cryptography), Perpendicular recording, Word error rate, Electrical and Electronic Engineering, Noise (electronics), Electronic, Optical and Magnetic Materials
Abstract

We describe an advanced dc-free track code pattern that uses diphase code for a perpendicular recording. Track code error rates are compared between diphase code, dummy-bit code, and conventional dibit code. The diphase code improves writing ability during servo track writing and maintains equivalent medium noise. Therefore, the diphase code exhibits a superior track code error rate within a wide range of radius on experimental hard disk drives.

Published
2005
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27. IL-6 mRNA synthesis by peripheral blood mononuclear cells (PBMC) in patients with chronic renal failure

Author

Tomohide Hirayama, Norio Kurumatani, Yasuhiro Akai, Yoshihiro Motomiya, T. Yamaguchi, Atsushi Kubo, Masayuki Iwano, Kazuhiro Dohi, T. Hamaguchi, Y Horii, and T. Fujimoto

Subjects
Adult, DNA, Complementary, medicine.medical_treatment, Molecular Sequence Data, Immunology, Peripheral blood mononuclear cell, Peritoneal dialysis, Renal Dialysis, Complementary DNA, Humans, Immunology and Allergy, Medicine, RNA, Messenger, Renal Insufficiency, Dialysis, Aged, Messenger RNA, Base Sequence, Interleukin-6, business.industry, Continuous ambulatory peritoneal dialysis, RNA, Original Articles, Middle Aged, Cytokine, Chronic Disease, Leukocytes, Mononuclear, business
Abstract

SUMMARY We measured levels of IL-6 mRNA in PBMC obtained from patients with chronic renal failure, using polymerase chain reaction (PCR), PBMC were isolated from 45 patients on haemodialysis (HD) at the start of HD. PBMC were also isolated from 35 patients on HD at the end of HD, 23 patients on continuous ambulatory peritoneal dialysis (CAPD), 24 undialysed patients with chronic renal failure (CRF), and 19 healthy controls. Total RNA was extracted from PBMC with RNA zol and reverse transcribed into cDNA. To prepare samples containing identical amounts of β-actin cDNA, we performed competitive PCR by co-amplifying serial dilutions of mutant templates containing a single point mutation which generated a unique Eco RI site. Next, to measure IL-6 cDNA semiquantitatively in the samples containing identical amounts of β-actin (100 pg), we performed PCR amplification using 2 fg of the IL-6 mutant template containing a unique Eco RI site. Higher levels of IL-6 mRNA in the PBMC were observed in the HD patients than in the CAPD patients and healthy controls. The levels of IL-6 mRNA in the PBMC at the end of HD were not significantly higher than those at the start of HD. These results suggest that the dialysis session itself did not significantly affect IL-6 mRNA levels in the PBMC, but that chronic stimulation by maintenance HD may be associated with higher levels of IL-6 mRNA observed in HD patients.

Published
1996
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28. Feasibility of endoscopic mucosal resection as salvage treatment for patients with local failure after definitive chemoradiotherapy for stage IB, II, and III esophageal squamous cell cancer

Author

M, Makazu, K, Kato, H, Takisawa, S, Yoshinaga, I, Oda, Y, Saito, H, Mayahara, Y, Ito, J, Itami, T, Hamaguchi, Y, Yamada, and Y, Shimada

Subjects
Male, Salvage Therapy, Mucous Membrane, Esophageal Neoplasms, Chemoradiotherapy, Middle Aged, Cohort Studies, Neoplasms, Multiple Primary, Treatment Outcome, Carcinoma, Squamous Cell, Feasibility Studies, Humans, Female, Esophageal Squamous Cell Carcinoma, Esophagoscopy, Treatment Failure, Neoplasm Recurrence, Local, Aged, Neoplasm Staging, Retrospective Studies
Abstract

Local failure after definitive chemoradiotherapy (CRT) for stage IB, II, and III esophageal cancer is one of the causes of poor outcome. Endoscopic mucosal resection (EMR) is an effective treatment for superficial esophageal cancer. However, its feasibility as a salvage treatment for local recurrent or residual tumors after definitive CRT for stage IB, II, and III esophageal cancer remains unclear. Between January 2000 and February 2008, 274 patients with stage IB, II, and III esophageal squamous cell cancer excluding T4 received definitive CRT at the National Cancer Center Hospital, Japan. Of these patients, nine patients with local recurrence after achieving complete response and two patients with residual tumor underwent salvage EMR. The technique of salvage EMR involved a strip biopsy method. We retrospectively reviewed the 11 patients (13 lesions). Characteristics of all 11 patients were as follows: median age of 69 (range: 45-78); male/female: 10/1; baseline clinical stage (Union for International Cancer Control 7th) IB/IIA/IIB/III: 1/3/7/0. The depth of resected tumor was limited to the mucosal layer in seven lesions and submucosal in six lesions. En bloc resection was performed on six lesions (46%). The vertical margin was free of cancer cells in 11 lesions (84.6%). No major complications, such as hemorrhage requiring blood transfusion and perforation, were experienced. At a median follow-up period of 38.9 months (range: 5.3-94 months) after salvage EMR, no recurrence was detected in six patients (54%). Local recurrence was detected in five patients (27%). Of these patients, two had lung metastasis simultaneously, and one was also detected lung metastasis 2 months after the detection of local recurrence. The 5-year survival rate after salvage EMR was 41.6%. Salvage EMR is a feasible treatment option for local recurrent or residual lesions after definitive chemotherapy and/or radiotherapy for stage IB, II, and III esophageal squamous cell cancer.

Published
2013

29. Evaluation of Oxygen‐Related Carrier Recombination Centers in High‐Purity Czochralski‐Grown Si Crystals by the Bulk Lifetime Measurements

Author

T. Takenaka, T. Hamaguchi, Yutaka Kitagawara, and T. Yoshida

Subjects
Effective density, Renewable Energy, Sustainability and the Environment, Chemistry, Precipitation (chemistry), Analytical chemistry, Mineralogy, chemistry.chemical_element, Condensed Matter Physics, Oxygen, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Crystal, Oxygen precipitation, Electrical resistivity and conductivity, Materials Chemistry, Electrochemistry, Limiting oxygen concentration, Recombination
Abstract

Present day high-purity Czochralski(CZ)-grown Si crystals are characterized by the bulk carrier recombination lifetime measurements. The bulk lifetime of the p-type as-grown Si with resistivity ∼10 Ω-cm is found to be as high as 500 μs for a CZ-Si crystal with [O i ] > 10 ppma-JEIDA and as high as ∼1 ms or even higher for a low-oxygen CZ-Si crystal with [O i ] < 10 ppma-JEIDA. The as-grown bulk lifetime is revealed to depend not only on resistivity under the framework of the Shockley-Read-Hall (SRH) relation, but also on the oxygen concentration. The dominant recombination center of the as-grown crystal is found to be an SRH-type deep-level center which is considered to be an oxygen-related defect complex. The complex is quenched easily by a heat-treatment at a temperature as low as 650°C. Effective density of a recombination center, existing after the 650°C heat-treatment in the p-type crystal, correlates well with the amount of oxygen precipitation generated by a subsequent two-step heat process [800°C for 4 h + 1000°C for 16 h]. Thus the dominant recombination center after the 650°C heat-treatment is considered to be closely related to the oxygen precipitation nuclei toward the subsequent precipitation formation heat process.

Published
1995
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30. Study of coordination environments around Pd and Pt in a Pd-core Pt-shell nanoparticle during heating

Author

Y. Nagai, T. Nonaka, Y F Nishimura, T Hamaguchi, S. Yamaguchi, H Takagi, and K. Dohmae

Subjects
History, Materials science, Shell (structure), Analytical chemistry, Nanoparticle, Nanotechnology, 02 engineering and technology, Atmospheric temperature range, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Computer Science Applications, Education, X-ray absorption fine structure, Catalysis, Core (optical fiber), 0210 nano-technology, Stoichiometry
Abstract

Local coordination environments around Pd and Pt in a Pd-core Pt-shell nanoparticle (NP) at temperatures ranging from 473 to 873 K was evaluated by utilizing in situ XAFS measurement technique to investigate the temperature range in which a core-shell structure is preserved. The core-shell structure was considered to be kept up to 673 K and start to change at about 773 K. Heating to 873 K accelerated atomic mixing in the core-shell NPs. Catalytic properties of the present Pd-core Pt-shell NP are available in the stoichiometric C3H6-O2 atmosphere at temperatures less than 773 K at most.

Published
2016
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31. High-performance compact optical WDM transceiver module for passive double star subscriber systems

Author

Kiichi Yamashita, H. Kodera, S. Himi, N. Maeda, I. Ikushima, T. Hamaguchi, and M. Suzuki

Subjects
Engineering, business.industry, Optical communication, Multiplexer, Cable television, Atomic and Molecular Physics, and Optics, Optics, Wavelength-division multiplexing, Insertion loss, Power dividers and directional couplers, Optoelectronics, Transceiver, business, Sensitivity (electronics)
Abstract

High-performance transceiver-type optical WDM interface modules with a volume of only 36 cc have been developed for PDS subscriber systems. The new module comprises an optical WDM sub-module, hybrid-integrated transmitter and receiver circuits. In the WDM sub-module, a planar lightwave circuit chip was hermetically sealed together with laser and photodiode chips in order to minimize the size of the transceiver module. The lightwave circuit was formed on an optical-waveguide chip by adopting a high-silica based optical-waveguide technology. The circuit has a 3-dB directional coupler for bi-directional transmission with a 1.3-/spl mu/m wavelength through a single fiber and a wavelength division multiplexer between both 1.3-/spl mu/m and 1.55-/spl mu/m wavelengths. The overall characteristics of the fabricated WDM sub-module achieved were a responsitivity of 0.25/spl plusmn/0.05 A/W, an insertion loss approximately 3 dB at 1.55 /spl mu/m and an isolation of 35 dB between both wavelengths. Optical output power of the fabricated transceiver module was -3.8 dBm. Also, receiver sensitivity of less than -35 dBm with an overload of over -14 dBm were obtained by introducing high-speed automatic gain and threshold control techniques. Thus, an allowable span loss of over 30 dB and an optical dynamic range of over 20 dB were attained. The preamble bit length required to reach stable receiver operation was confirmed to be within three bits. >

Published
1995
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32. An anaerobic fluidized pellet bed bioreactor process for simultaneous removal of organic, nitrogenous and phosphorus substances

Author

Tatsuo Shimizu, G. Ozawa, T. Hamaguchi, Kenzo Kudo, and Norihito Tambo

Subjects
Flocculation, Suspended solids, Environmental Engineering, Denitrification, Waste management, Chemistry, Ecological Modeling, technology, industry, and agriculture, Pollution, Clarifier, Activated sludge, Bioreactor, Sewage treatment, Aeration, Waste Management and Disposal, Water Science and Technology, Civil and Structural Engineering
Abstract

A new wastewater treatment process, which is named herein “the anaerobic fluidized pellet bed (AFPB) bioreactor process”, is developed for simultaneous removal of suspended solids, organic matter, phosphorus and nitrogen. This process is composed of two stages: an upflow AFPB bioreactor for the first stage and an activated sludge aeration tank with a sludge settling zone for the second stage. The first stage, the AFPB bioreactor, is introduced as an alternative to the primary clarifier. In this stage, polymerized aluminum chloride and a weak anionic polymer are dosed in order to coagulate suspended solids, colloidal matters and phosphorus and to generate sludge pellets that are large enough to settle rapidly. The excess sludge pellets are withdrawn from the bottom of the AFPB bioreactor. The second stage is primarily designed for the usual aerobic biological treatment of organic matter. In addition, as the aeration tank is operated at solid retention times long enough to ensure the growth of nitrifiers even at temperatures below 10°C, high nitrification is achieved in the second stage. The nitrified effluent is recycled from the second stage to the AFPB bioreactor, and denitrification completely accomplished under the anaerobic conditions. The organic matter necessary for the denitrification is supplied through anaerobic biological hydrolysis of the sludge pellets in the AFPB bioreactor. With a total retention time of 4 h (2 h in the AFPB bioreactor and 2 h in the aeration tank) and a recirculation ratio of 300% based on the influent flow rate, the average removal efficiencies of suspended solids, total COD and total nitrogen are found to be 99, 95 and 75%, respectively. Total phosphorus was below the detectable level in most cases.

Published
1994
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33. Nash equilibrium retail prices in a linear duopoly market

Author

Koichi Nakade and T. Hamaguchi

Subjects
TheoryofComputation_MISCELLANEOUS, Factor market, Market clearing, Partial equilibrium, TheoryofComputation_GENERAL, Supply and demand, Oligopoly, Microeconomics, symbols.namesake, Nash equilibrium, ComputerApplications_GENERAL, Economics, symbols, Game theory, Duopoly
Abstract

In this study Nash equilibrium retail prices in a linear duopoly market are analyzed. It is found that the simple model, in which consumers buy items less than the critical price and do not buy otherwise, has theoretical problems and may have no equilibrium prices. The modified market model, which has two-stage critical prices, is proposed and the demand functions on retail prices are analyzed. This demand model is applied to a supply chain model with one supplier and two retailers.

Published
2011
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35. Recording Properties of Magneto-Optical Disks with Metal Guiding Layers

Author

T. Hamaguchi, Yumiko Ohashi, Riki Matsuda, Kazunari Taki, and Hideo Maruyama

Subjects
Kerr effect, Materials science, Magnetic domain, Recording layer, Total thickness, Magneto optical, law.invention, Metal, Crosstalk, Optics, law, Electrical and Electronic Engineering, Adaptive optics, Instrumentation, business.industry, Condensed Matter Physics, Laser, Electronic, Optical and Magnetic Materials, Lens (optics), Resist, visual_art, Optical recording, visual_art.visual_art_medium, Pitch tracking, business, Optical disc
Abstract

The track pitch of magneto-optical disks with metal guiding layers was reduced to less than the laser spot size by suppressing crosstalk. The recorded domain width was effectively confined by the width of the recording region in which the guiding layer was spirally removed. Improvement of the CNR was achieved by using the structure of substrate/enhancing layer/guiding layer/interference layer/recording layer. The total thickness of the enhancing and interference layers was adjusted in order to increase the Kerr effect enhancement, and a CNR of 47.1dB at 3.73 MHz was obtained for a track pitch of 1.0μm. Low crosstalk values of less than -28.8 dB and -26.2 dB were achieved at 1.0 MHz for track pitches of 1.0 and 0.9μm, respectively, with a conventional optical head having an objective lens of 0.53 NA and a 780-nm laser.

Published
1993
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36. Measurement of Slider/Disk Collision Forces Using Acoustic Emission Source Wave Analysis

Author

T. Hamaguchi, Masaaki Matsumoto, and A. Iida

Subjects
Engineering, Piezoelectric sensor, business.industry, Mechanical Engineering, Acoustics, Surfaces and Interfaces, Tribology, Collision, Physics::Geophysics, Surfaces, Coatings and Films, Amplitude, Optics, Acoustic emission, Mechanics of Materials, Slider, Lubrication, business, Electronic circuit
Abstract

A new measuring technique has been developed for the purpose of analyzing the slider/disk collision phenomena. Very small piezoelectric sensors are mounted on the slider. These sensors detect elastic waves (acoustic emission) in the slider which are induced by the collisions at the slider rail surface. In order to obtain input collision force quantitatively, the transfer function of the slider, sensor, and electric circuit is measured by the breaking pencil lead method. The inverse operation is also performed by using source wave analysis. Force amplitude of the order of 4˜20 mN and contact time of the order of 5˜22 μ are detected. Two types of collision force are observed. One has large amplitude and narrow time width and is conjectured to arise from collisions with hard projections. The other has small amplitude and wide time width and is conjectured to arise from collisions with soft projections. Presented as a Society of Tribologists and Lubrication Engineers paper at the ASME/STLE Tribology Conferenc...

Published
1993
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37. A technique for evaluating track deviation at nanometer-scale accuracy

Author

T. Hamaguchi, K. Shishida, Takashi Yamaguchi, and Kei Yasuna

Subjects
Nuclear magnetic resonance, Scale (ratio), Position (vector), Computer science, Track (disk drive), Acoustics, Interface (computing), Nanometre, Repeatability, Electrical and Electronic Engineering, Error detection and correction, Position sensor, Electronic, Optical and Magnetic Materials
Abstract

A technique for evaluating track deviation in magnetic disk drives has been developed. The technique uses an external position sensor and an error cancellation sequence, and enables measurement of track-to-track spacing. The resolution of track position is less than 2 nm. The repeatability is less than 5 nm. The technique helps reveal track alignment error, which needs to be reduced to achieve over-100-KTPI recording.

Published
2001
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39. Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex

Author

S, Yamamura, K, Ohoyama, T, Hamaguchi, M, Nakagawa, D, Suzuki, T, Matsumoto, E, Motomura, H, Tanii, T, Shiroyama, and M, Okada

Subjects
Dibenzothiepins, Male, Neurons, Mediodorsal Thalamic Nucleus, Ventral Tegmental Area, Action Potentials, Glutamic Acid, Prefrontal Cortex, Research Papers, Rats, Rats, Sprague-Dawley, Animals, Haloperidol, Raphe Nuclei, Biogenic Monoamines, Drug Interactions, Locus Coeruleus, gamma-Aminobutyric Acid, Antipsychotic Agents
Abstract

The atypical antipsychotic drug, zotepine, is effective in treatment of schizophrenia and acute mania, but the incidence of seizures during treatment is higher than with other antipsychotics. In addition, the mechanisms underlying the clinical actions of zotepine remain uncharacterized.The effects of intraperitoneal administration of zotepine and haloperidol on the extracellular levels of noradrenaline, dopamine, 5-HT, GABA, and glutamate in the medial prefrontal cortex (mPFC) were compared. Neuronal activities induced by each drug in the ventral tegmental area (VTA), locus coeruleus (LC), dorsal raphe nucleus (DRN) and mediodorsal thalamic nucleus (MTN) were also analysed.Haloperidol did not affect extracellular neurotransmitter levels in the mPFC. In contrast, zotepine activated neuronal activities in all nuclei and increased the extracellular levels of noradrenaline, dopamine, GABA, and glutamate in the mPFC, but not 5-HT levels. The zotepine-stimulated neuronal activity in the VTA, LC, DRN and MTN enhanced the release of dopamine, noradrenaline, 5-HT, glutamate and GABA in the mPFC, although the enhanced GABAergic transmission possibly inhibited noradrenaline, dopamine and 5-HT release. The other afferent to mPFC, which releases dopamine and noradrenaline, was partially insensitive to GABAergic inhibition, but possibly received stimulatory AMPA/glutamatergic regulation from the MTN.Our results indicated that the positive interaction between prefrontal catecholaminergic transmission and AMPA/glutamatergic transmission from MTN might explain the regulatory effects of zotepine on neurotransmitter release. A mechanism is suggested to account for the pharmacological profile of this atypical antipsychotic and for its pro-convulsive action.

Published
2009

40. Abnormal glucagon response to arginine and its normalization in obese hyperinsulinaemic patients with glucose intolerance: importance of insulin action on pancreatic Alpha cells

Author

T. Hamaguchi, Hideki Kishikawa, Hideo Fukushima, Kenshi Ichinose, M. Uehara, S. Wada, Tetsuya Shirotani, Kohei Yamaguchi, and Motoaki Shichiri

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Arginine, Glucagon, Alpha cell, Impaired glucose tolerance, Islets of Langerhans, Insulin resistance, Reference Values, Hyperinsulinism, Internal medicine, Insulin Secretion, Diabetes Mellitus, Internal Medicine, medicine, Humans, Insulin, Obesity, Pancreatic hormone, Artificial endocrine pancreas, business.industry, Glucose Tolerance Test, medicine.disease, Insulin oscillation, Kinetics, Endocrinology, Diabetes Mellitus, Type 2, Glucose Clamp Technique, Female, Insulin Resistance, business
Abstract

An excessive glucagon secretion to intravenous arginine infusion was found in obese hyperinsulinaemic patients with glucose intolerance. This study was designed to determine whether the glucagon hyperresponsiveness to arginine in these patients would improve by insulin infused at a high enough dose to overcome insulin resistance. By infusing high dose insulin during arginine infusion, the previously exaggerated glucagon response to arginine could be normalized. To normalize the abnormal glucagon response, insulin doses of 4.2 +/- 0.7 and 3.8 +/- 0.5 IU were required during arginine infusion in obese hyperinsulinaemic patients with impaired glucose tolerance and Type 2 (non-insulin-dependent) diabetes mellitus, respectively. This achieved plasma peak insulin levels 3 to 4 times higher than those observed in non-obese healthy subjects. Furthermore, we clarified whether or not the effect of normalizing insulin action and/or glycaemic excursions contributed to normalizing the exaggerated glucagon response to arginine in these patients. Blood glucose was clamped while high dose insulin was infused at the same levels as observed during the arginine infusion test with no insulin infusion. As a result, normalization of the exaggerated plasma glucagon response was achieved, whether hyperglycaemia existed or not. These results clearly demonstrate that, similar to non-obese hypoinsulinaemic Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients, the exaggerated Alpha-cell response to arginine infusion in obese hyperinsulinaemic patients with glucose intolerance is secondary to the reduction of insulin action on the pancreatic Alpha cell, and that the expression of insulin action plays an important part in normalizing these abnormalities.

Published
1991
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41. Temperature dependence of minority‐carrier lifetime in iron‐diffusedp‐type silicon wafers

Author

Y. Hayamizu, S. Ushio, T. Abe, F. Shimura, and T. Hamaguchi

Subjects
inorganic chemicals, Silicon, business.industry, Chemistry, Doping, Analytical chemistry, General Physics and Astronomy, chemistry.chemical_element, Carrier lifetime, Atmospheric temperature range, Laser, Penning trap, law.invention, law, Optoelectronics, Wafer, business, Microwave
Abstract

Minority‐carrier recombination lifetime was measured with a noncontact laser/microwave method for nondiffused and iron‐diffused p‐type silicon wafers in the temperature range from 28 °C to 230 °C. The lifetime increased monotonically with temperature in nondiffused silicon, while the lifetime in iron‐diffused silicon showed a broad peak around 110 °C and a depression around 170 °C. The temperature dependence of the lifetime in iron‐diffused silicon was analyzed based on Shockley–Read–Hall statistics. The origin of the lifetime temperature dependence was attributed to the dissociation of iron‐boron pairs. Our experimental data supported that an electron trap for an iron‐boron pair at Ec−0.29 eV was more effective as a recombination center than a hole trap at Ev + 0.1 eV. It was also shown that the effect of iron in concentrations as low as 1×1011 cm−3 on the lifetime can be detected with the noncontact laser/microwave method.

Published
1991
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42. Rough Set Approximations Based on Random Sets

Author

T. Hamaguchi, Hiroshi Nakajima, Hiroshi Tasaki, S. Oku, Naoki Tsuchiya, Mitsuhiro Yoneda, and Toshikazu Shiga

Subjects
Signal processing, Cardinality, business.industry, Feature (computer vision), Computer science, Stability (learning theory), Point (geometry), Pattern recognition, Artificial intelligence, Akaike information criterion, business, Bioelectrical impedance analysis, Selection (genetic algorithm)
Abstract

The method of bioelectrical impedance-based visceral fat estimation is in advance of other methods such as X-ray CT or MRI from the point views of cost and safety. However, it requires complex and diversity signal analysis and modeling to realize its high estimation accuracy. In response to this requirement, complication of feature attributes and simplification in selection of them to model the estimation has been proposed and evaluated in this paper. The complication of feature attributes is realized by applying priori knowledge and by employing the idea of cardinality as quantitative evaluation index. The simplification of the estimation model is realized by employing Akaike information criteria. The experiments were conducted to evaluate the proposed method and the results prove high estimation accuracy and stability of the proposed method.

Published
2007
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44. Optimal track-width design of AMR/GMR heads for high-track-density disk drives

Author

Takashi Yamaguchi, Naoki Kodama, Hisashi Takano, Futoshi Tomiyama, Hiroshi Ide, and T. Hamaguchi

Subjects
Recording head, Computer science, Track (disk drive), Magnetic storage, Process (computing), Giant magnetoresistance, Electronic, Optical and Magnetic Materials, law.invention, Soft error, law, Contour line, Sensitivity (control systems), Electrical and Electronic Engineering, Algorithm
Abstract

The optimization of the write and read track-widths based on the new concept of a soft error rate (SER) contour map is proposed. In the calculation of the SER, the side fringe erase bands, microtrack MR sensitivity profile, and mechanical positioning accuracy are taken into account. From the SER map, nominal write and read track-widths can be optimized so that the process tolerance of the track-width can be maximized. Highly improved accurate positioning techniques for sub-micron track-width processing and suppression of the erase band are necessary for realizing areal densities over 10 Gb/in/sup 2/.

Published
1998
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45. A Millimeterwave Microstrip Antenna with Micromachined Wafer-Level Stacking Structure

Author

T. Nishino, Y. Koga, K. Nishizawa, M. Takeda, Y. Fujii, Yukihisa Yoshida, Y. Yokoyama, A. Yamashita, M. Taguchi, and T. Hamaguchi

Subjects
Patch antenna, Materials science, Coaxial antenna, Loop antenna, business.industry, Antenna measurement, Hardware_PERFORMANCEANDRELIABILITY, Antenna factor, law.invention, Microstrip antenna, Hardware_GENERAL, law, Hardware_INTEGRATEDCIRCUITS, Optoelectronics, Dipole antenna, business, Monopole antenna
Abstract

This paper presents a silicon-micromachined microstrip antenna in which both feeding power and ground interconnection are performed along the vertical direction of the substrate at the wafer level. The antenna has a stacked structure consisting of a patch antenna substrate and a feed substrate. The structure possesses the following novel points: (i) it satisfies both optimum design and ease of wafer handling in the fabrication process; (ii) the ground plane intervened in the microstrip antenna is interconnected by through-wafer vias. The measured radiation patterns of the developed antenna at an 80-GHz band showed good agreement with the designed patterns. This newly developed technology can be utilized for wafer-level stacking to achieve a compact array antenna in the millimeterwave range.

Published
2006
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46. Cavity-backed MEMS patch antennas on double-layer silicon wafers

Author

Shigeru Makino, Kazushi Nishizawa, Tamotsu Nishino, T. Hamaguchi, Yukihisa Yoshida, A. Yamashita, Hiroaki Miyashita, Y. Koga, and M. Taguchi

Subjects
Microelectromechanical systems, Permittivity, Materials science, Silicon, Physics::Instrumentation and Detectors, business.industry, Astrophysics::Instrumentation and Methods for Astrophysics, chemistry.chemical_element, Dielectric, Computer Science::Other, Microstrip antenna, chemistry, Extremely high frequency, Optoelectronics, Wafer, Antenna (radio), business, Computer Science::Information Theory
Abstract

This paper presents cavity-backed patch antennas on a double-layer silicon wafer. The developed antenna has flexibility for obtaining the desired equivalent dielectric constant under the limit of the wafer thickness, because a depth of cavity on each wafer can be adjusted with each other. The wide band characteristic of this antenna has been shown by simulation, and the experimental results at millimeter wave have also been presented

Published
2006
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48. Three-dimensional imaging with a multifrequency holographic method

Author

H. Ogura, T. Miyashita, and T. Hamaguchi

Subjects
Physics, Antenna array, Signal processing, Optics, Signal design, Three dimensional imaging, business.industry, law, Bandwidth (signal processing), Holography, business, law.invention
Abstract

This report proposes a three-dimensional imaging by computer with a multifrequency holographic method and shows that this imaging is very promising with a nonuniformly spaced two-dimensional antenna array and a nonuniformly spaced frequency array, presenting high-quality images reconstructed from multifrequency hologram data made by a computer simulation.

Published
2005
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49. Alternating-DC track servo pattern for perpendicular recording

Author

H. Maeda, K. Shishida, and T. Hamaguchi

Subjects
Physics, Magnetization, Optics, business.industry, Distortion, Reading (computer), Track (disk drive), Perpendicular, Perpendicular recording, Linearity, business, Servo
Abstract

A perpendicular recording system can provide improved writing ability on high-coercivity media and stabilize high-density bits against the superparamagnetic effect. On the other hand, when bits are written on a perpendicular medium at low density, as is the case with the PES (position error signal) region of a conventional servo pattern, linearity in reading/writing operations is distorted, which are strongly affected by the regions of dc magnetization. This paper presents a way in reducing such distortion of characteristics of reading/writing processes using perpendicular media.

Published
2005
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50. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author

S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. Nauck, A Ekbom-Schnell, G Deferrari, Riccardo Schiaffini, S. Pampanelli, Khan Aka., David Hopkins, Maija Wessman, M Kamarinos, Noh J-H., O Ebisui, K McCarroll, Jeppe Sturis, Peter Nowotny, N Gorbenko, Åke Sjöholm, David G. Maggs, A E Halseth, B Cresci, A A Ortiz-Gress, A Korakovouni, O Matejkova, C E Mogensen, C J Lin, Ramon Gomis, H Seaman, C Granier, Yang C-H., F Assah, O Sanchez, Fausto Machicao, Peter G. Morris, Alberto Ortiz, A Giardinelli, D Bracaglia, A Gonzalo, S Pavlatos, Andreas Lechner, F Canovic, L Sjolind, Allan Vaag, Birgitte Bruun Nielsen, David A. Ziegler, Vito Lampasona, R Gershoni-Baruch, A. Dei Cas, H Renz, E Mena, Matthew Waltham, Kim D-M., H Levanen, D D Mick, Valentina Alexandrovna Peterkova, E Meskhishvili, Sarah Nutland, R Bustani, John R. Lindsay, M Christoforidou, A Abicht, E Harno, K Cyganek, A Fitchet, S Neelotpol, P Nikishin, P Serradas, J Hinrichsen, M Halvorson, M Chovatia, B Voet, Jinny Willis, E Parretti, M Haslbeck, M Wellard, L Teng, Julio Wainstein, J S Fischer, K. Lalic, D Roggenland, I Gich, R Anwar, Maurizio Cassader, D Serota, X J Li, R J Schotzinger, Vilmundur Gudnason, Björn Zethelius, S A Wootton, W Andrzejewski, R Rezsohazy, R Gao, T Klimentova, T Mazurek, I Bruckner, C Dohrmann, R E James, G daSilva Xavier, Kim S-Y., A Dorca, Stuart J. Pocock, Terri J. Allen, I Giovos, P B Parab, N H Andersen, P Fotinakis, Miriam Cnop, H Lee, Norbert Tennagels, Omorodola I. Abatan, F Ailett, I. Lager, D Manzella, H Hut, Larry A. Distiller, G Lip, Lim S-K., Rong Zhang, T Tsuno, Steen Knudsen, M. Bajardi, Manuel Benito, Dai Sugimoto, Melvin J. Prince, D W Dunstan, D Rankins, K A Majali, G Ozansoy, Isabella Russo, S Uçak, G Annuzzi, R Talar-Wojnarowska, K Lange, S Neugebauer-Baba, Campbell H. Thompson, Eric Renard, P. D. Mountjoy, Z Morrison, Elizabeth A. Davis, Franco Cavallo, C Corvaja, R Antuña, Craig John Currie, H Linnebjerg, He Y-L., A J Palmer, Mariola R. Chacón, H Malinska, M. Jones, R Lichnovská, K Mandes, Paolo Tessari, T Mokhort, A Laina, H. L. Y. Chan, I Schmidt, R Banks, Richard G. IJzerman, L Ksinantova, G Setti, H Vaudry, A Gallo, V Spallone, Chen J-W., Thomas Danne, A Chong, M Hallschmid, S Aczel, S Hulme, N Islam, M Hosoi, P M Ternan, P Di Bartolo, N Bishara, T Shibasaki, Martin A. Osterhoff, Im S-S., M Jecht, T Hamaguchi, S Mattera, K Ways, Elizabeth Northam, U Rajala, Reinhard W. Holl, L Yang, S Panaiotopoulos, K Horvath, R Kluge, Thora B. Bodvarsdottir, Y Dong, Irene Alemanno, C McDougall, Reimar W. Thomsen, M Campbell, W Rabl, John Öhrvik, Yuichiro Yamada, Paola Ungaro, W Benzer, Mike Sampson, Roberto Trevisan, R G Radu, Aas A-M., P E Lobo, Ricardo Scott, S M Son, Josephine M. Forbes, T A Hillier, K L Wyne, Louis L. Nguyen, J Farmer, M H Tan, Kwon H-S., J Yang, L Sandvik, Franco Folli, A K Jenum, M Nguyen, W Pratipanawatr, A L Frederiksen, Rebecca Smith, Lee H-J., A Schäfer, C Manuelli, G S Denver, T Vukovich, B Maceira, K Matsumoto, K. Chokkalingam, Nurcan Üçeyler, P Modi, Timothy M. Morgan, S Mertens, B M Singh, Michaela Riedl, K Iso, C Cucurullo, G. F. Bottazzo, M Calvani, K Hur, J Wetzels, Kazuhiro Takahashi, Y Aso, H Stammer, M G Masding, Fitsum Guebre-Egziabher, J L González-Sánchez, L Armstrong, Alberto Maran, Peter G.F. Swift, S S Popovic, J Starczynski, E Vitacolonna, Luigi Laviola, R W Gelling, Marina Cardellini, D Barilla, Rosa de Diego Martínez, W H Landschulz, Anne Mette Rosenfalck, R K Wong, Kevin E. Schneider, K Peros, Giuseppe Nanni, F Zhang, I Rákóczi, T Iburi, M Nakhjavani, X Q Zhang, S Tournis, Per Lav Madsen, Graham A. Hitman, A. Tura, K Laubner, N D Kostic, Lawrence M. Dolan, R. Sinha Roy, J A Wagner, J. 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Subjects
0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published
2004

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