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2. COVAC1 phase 2a expanded safety and immunogenicity study of a self-amplifying RNA vaccine against SARS-CoV-2

Author

Szubert, Alex J., Pollock, Katrina M., Cheeseman, Hannah M., Alagaratnam, Jasmini, Bern, Henry, Bird, Olivia, Boffito, Marta, Byrne, Ruth, Cole, Tom, Cosgrove, Catherine A., Faust, Saul N., Fidler, Sarah, Galiza, Eva, Hassanin, Hana, Kalyan, Mohini, Libri, Vincenzo, McFarlane, Leon R., Milinkovic, Ana, O'Hara, Jessica, Owen, David R., Owens, Daniel, Pacurar, Mihaela, Rampling, Tommy, Skene, Simon, Winston, Alan, Woolley, James, Yim, Yee Ting N., Dunn, David T., McCormack, Sheena, and Shattock, Robin J.

Published
2023
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3. Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial

Author

Scarborough, Matthew, Kamfose, Musa, de Veciana, Ana, Gordon, Nicola Claire, Peto, Leon, Pill, Gemma, Clarke, Tiphanie, Watson, Laura, Young, Bernadette, Griffiths, Dai, Vaughn, Ali, Anson, Luke, Liu, Elian, Perera, Sanuki, Rylance-Knight, Lydia, Cantell, Carmen, Moroney, Ruth, Edgeworth, Jonathan D, Thwaites, Guy, Bisnauthsing, Karen, Querol-Rubiera, Antonio, Gibbs, Charlotte, Patel, Amita, Hemsley, Carolyn, Goodman, Anna L, Wyncoll, Duncan, Biswas, Jason, Fitzpatrick, Jennifer, Roberts, Lizzie, Millard, James, Stone, Neil, Cape, Angela, Hurley, Lisa, Tam, Chi Kai, Nsutebu, Emmanuel, Hoyle, Marie-Claire, Maitland, Kate, Trainor, Leona, Reynolds, Helen, Harrison, Jennifer, Anson, Jim, Lewis, Joseph, Folb, Jonathan, Goodwin, Lynsey, Beeching, Nicholas, Dyas, Sarah, Winslow, Helen, Foote, Elizabeth, Roberts, Paul, Natarajan, Pavithra, Chrdle, Alex, Fenech, Manuel, Allsop, Hannah, Tilley, Robert, Austin-Hutchison, Rachel, Barrett, Louise, Brookes, Karen, Carwithen, Leanne, Conbeer, Andrew, Cunningham, Richard, Eglinton, Charlotte, Fok, Rosie, Gott, Hannah, Hughes, Shona, Jones, Lewis, Kalita, Maggie, King, Angela, March, Linda, Marner, Mike, Mynes, Tracey, Plant, Aiden, Price, Suzanne, Sercombe, Judy, Stolton, Alison, Wallis, Mark, West, Marie-Claire, Westcott, Jackie, Williams, Claire, Wosley, Rob, Yabsley, Leona, Greig, Julia, Butland, Laura, Sorrell, Julie, Mitchell, Tamara, Alli, Abiola, Meiring, James, Masake, Boingotlo, Rowson, Carlene, Smart, Lynne, Makey, Laura, Moll, Sarah, Cunningham, Jane, Ryalls, Kim, Birchall, Kathryn, Middle, Janet, Jackson, Yvonne, Swift, Diane, Cole, Joby, Subramanian, Bala, Okhuoya, Faith, Edwards, Maria, Bailey, Cheryl, Warren, Rebecca, Islam, Gayti, Ankcorn, Michael, Birchall, Sarah, Jones, Paul, Humphries, John, Booth, Stephen, Evan, Cariad, Wyllie, Sarah, Flatt, Andrew, Strakova, Lenka, Hayes, Maria, Valentine, Stacey, James, Clare, Wands, Mary, Cortes, Nicolas, Khan, Nisa, Porter, Robert, Martin, Zoe, Yip, Keith, Preedy, Helen, Chesterfield, Helen, Dobson, Tracey, Walker, Colin, Llewelyn, Martin, Dunne, Angela, Latter, Laura, Porges, Alison, Price, James, Paul, John, Behar, Laura, Robinson, Louise, Murray, Amy, Sargent, Tenessa, Ridley, Carrie, de Gordoa, Laura Ortiz-Ruiz, Gilliam, Deborah, McPherson, Carole, Matthews, Simon, Foreman, Emma, Jarghese, Rajesh, Beddoe, Alisha, Martin, Sebastien, Shaw, Sephora, Wlazly, Dominika, Cole, Maggie, Gihawi, Abraham, Cole, Kevin, Török, M Estée, Gouliouris, Theodore, Bedford, Luke, Saunderson, Rebecca B, Mariolis, Ilias, Bousfield, Rachel, Ramsay, Isobel, Greaves, Daniel, Aliyu, Sani, Cox, Kim, Mlemba, Lois, Whitehead, Lynne, Vyse, Naval, Bolton, Mark, Williams, John, Lambert, Pauline, Chadwick, David, Baillie, Kirsty, Cain, Martyn, Bellamy, Richard, Wong, Jason, Thompson, Jane, Vassallo, Helen, Skotnicka, Agnieszka, Boyce, Andrea, Donnelly, Anthony, Wilson, Peter, FitzGerald, Graham, Dean, Victoria, Warnes, Kristian, Reyes, Anna, Rahman, Saadia, Tsang, Lillian, Williams, Joanne, Morris-Jones, Stephen, Hopkins, Susan, Witness, Elen, Brady, Orla, Woodford, Elizabeth, Pettifer, Teresa, McCadden, Angela, Marks, Ben, Collier, Sophie, Mack, Damien, Warren, Simon, Brown, Colin, Lyons, Adrian, Taiyari, Sara, Mepham, Stephen, Sweeney, Anna, Brown, Li-An, Auckland, Cressida, Potter, Alison, Mandiza, Jess, Hough, Maxine, Williams, Sue, Renton, Caroline, Walters, Fiona, Nadolski, Maria, Evans, Andree, Tarrant, Polly, Curley, Katherine, Whiteley, Sophie, Halpin, Julia, Hutchings, Melanie, Todd, Shirley, Lohan, Christop, Chapter, Tamika, Folland, Emma, Colville, Alaric, Marden, Katy, Morgan, Marina, Porter, Rob, Baxter, Mel, Minton, Jane, Rippon, Sarah, Cevik, Muge, Chapman, Judith, Kemp, Tim, Vincent, Rachel, Osborne, Dave, Platt, Tracey, Calderwood, James, Cook, Bernadette, Bedford, Caroline, Galloway-Browne, Leanne, Abberley, Nadine, Attack, Kelly, Allen, Joanna, Lal, Pankaj, Harrison, Melanie, Stevenson, Sarah, Brooks, Carol, Harlow, Paula, Ewing, Jordan, Cooper, Shirley, Balancio-Tolentino, Roderick, O'Neil, Laura, Tagney, Rebecca, Shackcloth, Daniela, Planche, Tim, Fellows, James, Millett, Ruth, Studham, Jo, de Souza, Cherrelle, Howell, Geoffrey, Greaves, Hezron, Foncel, Ella, Kurup, Rahul, Briggs, Jack, Smith, Melody, Suarez, Cristina, Sorrentino, Giordana, Scobie, Antonia, Houston, Angela, Ahmad, Fozia, Breathnach, Aodhan, Chahuan, Rakhee, Wilkins, Katie, Guleri, Achyut, Waddington, Natalia, Sharma, Rashmi, Flegg, Peter, Kollipara, Veenu, Alam, Mazhar, Potter, Andrew, Donaldson, Stacey, Armer, Charlote, Frudd, Julie, Jeyaratnam, Dakshika, Joy, Manju, Mathews, Asha, Glass, Stephen K, Ajayi, Ayodele, Fife, Amanda, Qaiser, Saba, Sheehan, Sharon, Muñoz-Villaverde, Sergio, Yogo, Noah, De Abreu, Ines, Notcheva, Gaynor, Flanagan, Joanna, Watson, Cordelia, Sais, Efisia, Adedayo, Adetunji, Chu, Vicky, Shaw, Georgina, Graver, Michelle A, Palmer, Rebecca, Palmer, Donna, Haile, Senait, Gordon, Joanne, Mandar, Kirandip, Szypura, Weronika, Jenkins, Neil, Marange, Josephine, Shabangu, Vusumuzi, Moore, Katy, Lyons, Jill, Munang, Melinda, Sangombe, Mirriam, Moran, Ed, Hussain, Abid, Wiselka, Martin, Lewszuk, Adam, Batham, Sally, Ellis, Kate, Bahadur, Leila, White, Helena, Pareek, Manish, Sahota, Amandip, Coleman, Stephen, Pateman, Hilary, Kotecha, Atul, Sim, Christopher, Rosser, Andrew, Deane, Jill, Nendick, Richard, Aldridge, Catherine, Clarke, Anne, Wood, Michelle, Marshall, Adele, Stephenson, Lynsey, Matheson-Smith, Tracy, Sloss, John, Potts, Kathryn, Malkin, Joanne, Ftika, Lemonia, Raviprakash, Veena, Sutton, Julian, Malachira, Ahalya, Kean, Miranda, Criste, Kristine, Gladas, Kirsty, Andrews, Caroline, Hutchison, Clare, Adams, Ellen, Andrews, Janet, Romans, Belinda, Ridley, Nicola, Ekani, Melanie, Mitchell, Julie, Smith, Nicola, Clark, Tristan, Glover, Sarah, Reed, Robert, Yam, Tat, Burton, Holly, Said, Rasha, Harvey, David, Janvier, Amy, Jacob, Reni, Smalley, Chris, Fair, Alison, Lord, Susan, Ripalda, Kate, Wooldridge, Helen, Cotter, Luis, Cardoso, Gus, Strachan, Elaine, Kaler, Gagan, Mohamoodally, Adam, Lawrence, Emma, Prime, Zoe, Abrahams, Rachel, Price, David Ashley, Rigden, Lesley, Shewan, Laura, Cullen, Katherine, Emmerson, Ingrid, Martin, Karen, Wilson, Hesther, Higham, Charley, Taylor, Kathryn Louise, Ong, Edmund, Patel, Bijal, Bond, Helena, Gradwell, Janine, Widdrington, John, Graham, Clive, Thornthwaite, Sarah, Prentice, Scott, Poultney, Una, Crowther, Hannah, Fairlamb, Helen, Hetherington, Emily, Brewer, Chris, Banerjee, Suryabrata, Hamson, Clare, McSkeane, Anna, McWhinney, Paul, Sharratt, Paula, Thorpe, Joanne, Kimachia, Sue, Wilson, Helen, Jeffs, Benjamin, Masters, Leslie, Wilson, Jonathan, Platt, Judith, Burgess, Lisa, Chadwick, Paul, Jeans, Adam, Keatley, Claire, Moran, Amanda, Swann, Zoe, Pagett, Katherine, Peel, Alex, Howard, Jason, Meisner, Sarah, Maloney, Kate, Masdin, Avril, Wright, Louise, Barlow, Gavin, Crossman, Samantha, Lowthorpe, Vicki, Moore, Emma, Moss, Peter, Parkin, Angela, Wolstencroft, Adam, Warner, Bev, Tarbotton, Clare, Eyre, Alison, Anderson, Anne, Burdett, Tina, Driffill, Amy, Walker, Ann Sarah, Hudson, Fleur, Szubert, Alex, Cairns, Janet, Ward, Denise, Webb, Helen, Russell, Charlotte, Jackson, Brooke, Otiko, Damilola, Borg, Chiara, Masters, Lindsey, Islam, Zaheer, Díaz-Montaña, Carlos, Johnson, Debbie, Thwaites, Guy E, Szubert, Alexander, Wyllie, Sarah A, Armando, Gonzalez-Ruiz, Chadwick, Paul R, Gordon, N Claire, Price, David A, Nayar, Deepa, Török, M Estee, Llewelyn, Martin J, and Walker, A Sarah

Published
2018
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9. Supplementary Methods, References, Legends for Table 1 and Figure 1 from Gender Disparities in the Tumor Genetics and Clinical Outcome of Multiple Myeloma

Author

Boyd, Kevin D., primary, Ross, Fiona M., primary, Chiecchio, Laura, primary, Dagrada, GianPaolo, primary, Konn, Zoe J., primary, Tapper, William J., primary, Walker, Brian A., primary, Wardell, Christopher P., primary, Gregory, Walter M., primary, Szubert, Alex J., primary, Davies, Faith E., primary, and Morgan, Gareth J., primary

Published
2023
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11. Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial

Author

Morgan, Gareth J, Child, J Anthony, Gregory, Walter M, Szubert, Alex J, Cocks, Kim, Bell, Sue E, Navarro-Coy, Nuria, Drayson, Mark T, Owen, Roger G, Feyler, Sylvia, Ashcroft, A John, Ross, Fiona M, Byrne, Jennifer, Roddie, Huw, Rudin, Claudius, Cook, Gordon, Jackson, Graham H, Wu, Ping, and Davies, Faith E

Published
2011
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13. Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa

Author

Hakim, James, Musiime, Victor, Szubert, Alex J., Mallewa, Jane, Siika, Abraham, Agutu, Clara, Walker, Simon, Pett, Sarah L., Bwakura-Dangarembizi, Mutsa, Lugemwa, Abbas, Kaunda, Symon, Karoney, Mercy, Musoro, Godfrey, Kabahenda, Sheila, Nathoo, Kusum, Maitland, Kathryn, Griffiths, Anna, Thomason, Margaret J., Kityo, Cissy, Mugyenyi, Peter, Prendergast, Andrew J., Walker, A. Sarah, Gibb, Diana M., REALITY Trial Team, O'Hare, Bernadette Ann-Marie, DiFDMRCWellcome Trust, University of St Andrews. School of Medicine, and University of St Andrews. Infection and Global Health Division

Subjects
Male, REALITY Trial Team, 0301 basic medicine, Placebo-controlled study, CHILDREN, HIV Infections, Kaplan-Meier Estimate, law.invention, DOUBLE-BLIND, 0302 clinical medicine, Anti-Infective Agents, Randomized controlled trial, WORLDWIDE, law, Medicine, 030212 general & internal medicine, Child, 11 Medical and Health Sciences, Medicine(all), education.field_of_study, Mortality rate, Pyridoxine, General Medicine, Middle Aged, OPEN-LABEL, 3. Good health, Anti-Retroviral Agents, Chemoprophylaxis, Drug Therapy, Combination, Female, Life Sciences & Biomedicine, medicine.drug, Adult, medicine.medical_specialty, Tuberculosis, Adolescent, 030106 microbiology, Population, NDAS, R Medicine, TUBERCULOSIS, Article, Young Adult, 03 medical and health sciences, Medicine, General & Internal, Pharmacotherapy, SDG 3 - Good Health and Well-being, PEOPLE, General & Internal Medicine, Internal medicine, Trimethoprim, Sulfamethoxazole Drug Combination, Isoniazid, Humans, Intensive care medicine, education, Africa South of the Sahara, Aged, Science & Technology, AIDS-Related Opportunistic Infections, business.industry, MORTALITY, ADULTS, Raltegravir, medicine.disease, CD4 Lymphocyte Count, HIV-1, business, CRYPTOCOCCAL MENINGITIS
Abstract

Supported by the Joint Global Health Trials Scheme of the Medical Research Council (MRC), the U.K. Department for International Development, and the Wellcome Trust through a grant (G1100693),with additional support from the PENTA Foundation. The MRC Clinical Trials Unit at University College London is supported by grants from the MRC (MC-UU-12023/23 and MC-UU-12023/26). Dr. Prendergast is funded by a grant (108065/Z/15/Z) from the Wellcome Trust, which also funds the Malawi–Liverpool–Wellcome Trust Clinical Research Program at the University of Malawi College of Medicine through a grant (101113/Z/13/Z) and the Kenya Medical Research Institute (KEMRI)–Wellcome Trust Research Program through a grant (077092). Background: In sub-Saharan Africa, among patients with advanced human immunodeficiency virus (HIV) infection, the rate of death from infection (including tuberculosis and cryptococcus) shortly after the initiation of antiretroviral therapy (ART) is approximately 10%. Methods: In this factorial open-label trial conducted in Uganda, Zimbabwe, Malawi, and Kenya, we enrolled HIV-infected adults and children 5 years of age or older who had not received previous ART and were starting ART with a CD4+ count of fewer than 100 cells per cubic millimeter. They underwent simultaneous randomization to receive enhanced antimicrobial prophylaxis or standard prophylaxis, adjunctive raltegravir or no raltegravir, and supplementary food or no supplementary food. Here, we report on the effects of enhanced antimicrobial prophylaxis, which consisted of continuous trimethoprim-sulfamethoxazole plus at least 12 weeks of isoniazid-pyridoxine (coformulated with trimethoprim-sulfamethoxazole in a single fixed-dose combination tablet), 12 weeks of fluconazole, 5 days of azithromycin, and a single dose of albendazole, as compared with standard prophylaxis (trimethoprim-sulfamethoxazole alone). The primary end point was 24-week mortality. Results: A total of 1805 patients (1733 adults and 72 children or adolescents) underwent randomization to receive either enhanced prophylaxis (906 patients) or standard prophylaxis (899 patients) and were followed for 48 weeks (loss to follow-up, 3.1%). The median baseline CD4+ count was 37 cells per cubic millimeter, but 854 patients (47.3%) were asymptomatic or mildly symptomatic. In the Kaplan-Meier analysis at 24 weeks, the rate of death with enhanced prophylaxis was lower than that with standard prophylaxis (80 patients [8.9% vs. 108 [12.2%]; hazard ratio, 0.73; 95% confidence interval [CI], 0.55 to 0.98; P = 0.03); 98 patients (11.0%) and 127 (14.4%), respectively, had died by 48 weeks (hazard ratio, 0.76; 95% CI, 0.58 to 0.99; P = 0.04). Patients in the enhanced-prophylaxis group had significantly lower rates of tuberculosis (P = 0.02), cryptococcal infection (P = 0.01), oral or esophageal candidiasis (P = 0.02), death of unknown cause (P = 0.03), and new hospitalization (P = 0.03). However, there was no significant between-group difference in the rate of severe bacterial infection (P = 0.32). There were nonsignificantly lower rates of serious adverse events and grade 4 adverse events in the enhanced-prophylaxis group (P = 0.08 and P = 0.09, respectively). Rates of HIV viral suppression and adherence to ART were similar in the two groups. Conclusions: Among HIV-infected patients with advanced immunosuppression, enhanced antimicrobial prophylaxis combined with ART resulted in reduced rates of death at both 24 weeks and 48 weeks without compromising viral suppression or increasing toxic effects. Publisher PDF

Published
2017

14. Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial

Author

Thwaites, Guy E, primary, Scarborough, Matthew, additional, Szubert, Alexander, additional, Nsutebu, Emmanuel, additional, Tilley, Robert, additional, Greig, Julia, additional, Wyllie, Sarah A, additional, Wilson, Peter, additional, Auckland, Cressida, additional, Cairns, Janet, additional, Ward, Denise, additional, Lal, Pankaj, additional, Guleri, Achyut, additional, Jenkins, Neil, additional, Sutton, Julian, additional, Wiselka, Martin, additional, Armando, Gonzalez-Ruiz, additional, Graham, Clive, additional, Chadwick, Paul R, additional, Barlow, Gavin, additional, Gordon, N Claire, additional, Young, Bernadette, additional, Meisner, Sarah, additional, McWhinney, Paul, additional, Price, David A, additional, Harvey, David, additional, Nayar, Deepa, additional, Jeyaratnam, Dakshika, additional, Planche, Tim, additional, Minton, Jane, additional, Hudson, Fleur, additional, Hopkins, Susan, additional, Williams, John, additional, Török, M Estee, additional, Llewelyn, Martin J, additional, Edgeworth, Jonathan D, additional, Walker, A Sarah, additional, Kamfose, Musa, additional, de Veciana, Ana, additional, Gordon, Nicola Claire, additional, Peto, Leon, additional, Pill, Gemma, additional, Clarke, Tiphanie, additional, Watson, Laura, additional, Griffiths, Dai, additional, Vaughn, Ali, additional, Anson, Luke, additional, Liu, Elian, additional, Perera, Sanuki, additional, Rylance-Knight, Lydia, additional, Cantell, Carmen, additional, Moroney, Ruth, additional, Thwaites, Guy, additional, Bisnauthsing, Karen, additional, Querol-Rubiera, Antonio, additional, Gibbs, Charlotte, additional, Patel, Amita, additional, Hemsley, Carolyn, additional, Goodman, Anna L, additional, Wyncoll, Duncan, additional, Biswas, Jason, additional, Fitzpatrick, Jennifer, additional, Roberts, Lizzie, additional, Millard, James, additional, Stone, Neil, additional, Cape, Angela, additional, Hurley, Lisa, additional, Tam, Chi Kai, additional, Hoyle, Marie-Claire, additional, Maitland, Kate, additional, Trainor, Leona, additional, Reynolds, Helen, additional, Harrison, Jennifer, additional, Anson, Jim, additional, Lewis, Joseph, additional, Folb, Jonathan, additional, Goodwin, Lynsey, additional, Beeching, Nicholas, additional, Dyas, Sarah, additional, Winslow, Helen, additional, Foote, Elizabeth, additional, Roberts, Paul, additional, Natarajan, Pavithra, additional, Chrdle, Alex, additional, Fenech, Manuel, additional, Allsop, Hannah, additional, Austin-Hutchison, Rachel, additional, Barrett, Louise, additional, Brookes, Karen, additional, Carwithen, Leanne, additional, Conbeer, Andrew, additional, Cunningham, Richard, additional, Eglinton, Charlotte, additional, Fok, Rosie, additional, Gott, Hannah, additional, Hughes, Shona, additional, Jones, Lewis, additional, Kalita, Maggie, additional, King, Angela, additional, March, Linda, additional, Marner, Mike, additional, Mynes, Tracey, additional, Plant, Aiden, additional, Price, Suzanne, additional, Sercombe, Judy, additional, Stolton, Alison, additional, Wallis, Mark, additional, West, Marie-Claire, additional, Westcott, Jackie, additional, Williams, Claire, additional, Wosley, Rob, additional, Yabsley, Leona, additional, Butland, Laura, additional, Sorrell, Julie, additional, Mitchell, Tamara, additional, Alli, Abiola, additional, Meiring, James, additional, Masake, Boingotlo, additional, Rowson, Carlene, additional, Smart, Lynne, additional, Makey, Laura, additional, Moll, Sarah, additional, Cunningham, Jane, additional, Ryalls, Kim, additional, Birchall, Kathryn, additional, Middle, Janet, additional, Jackson, Yvonne, additional, Swift, Diane, additional, Cole, Joby, additional, Subramanian, Bala, additional, Okhuoya, Faith, additional, Edwards, Maria, additional, Bailey, Cheryl, additional, Warren, Rebecca, additional, Islam, Gayti, additional, Ankcorn, Michael, additional, Birchall, Sarah, additional, Jones, Paul, additional, Humphries, John, additional, Booth, Stephen, additional, Evan, Cariad, additional, Wyllie, Sarah, additional, Flatt, Andrew, additional, Strakova, Lenka, additional, Hayes, Maria, additional, Valentine, Stacey, additional, James, Clare, additional, Wands, Mary, additional, Cortes, Nicolas, additional, Khan, Nisa, additional, Porter, Robert, additional, Martin, Zoe, additional, Yip, Keith, additional, Preedy, Helen, additional, Chesterfield, Helen, additional, Dobson, Tracey, additional, Walker, Colin, additional, Llewelyn, Martin, additional, Dunne, Angela, additional, Latter, Laura, additional, Porges, Alison, additional, Price, James, additional, Paul, John, additional, Behar, Laura, additional, Robinson, Louise, additional, Murray, Amy, additional, Sargent, Tenessa, additional, Ridley, Carrie, additional, de Gordoa, Laura Ortiz-Ruiz, additional, Gilliam, Deborah, additional, McPherson, Carole, additional, Matthews, Simon, additional, Foreman, Emma, additional, Jarghese, Rajesh, additional, Beddoe, Alisha, additional, Martin, Sebastien, additional, Shaw, Sephora, additional, Wlazly, Dominika, additional, Cole, Maggie, additional, Gihawi, Abraham, additional, Cole, Kevin, additional, Török, M Estée, additional, Gouliouris, Theodore, additional, Bedford, Luke, additional, Saunderson, Rebecca B, additional, Mariolis, Ilias, additional, Bousfield, Rachel, additional, Ramsay, Isobel, additional, Greaves, Daniel, additional, Aliyu, Sani, additional, Cox, Kim, additional, Mlemba, Lois, additional, Whitehead, Lynne, additional, Vyse, Naval, additional, Bolton, Mark, additional, Lambert, Pauline, additional, Chadwick, David, additional, Baillie, Kirsty, additional, Cain, Martyn, additional, Bellamy, Richard, additional, Wong, Jason, additional, Thompson, Jane, additional, Vassallo, Helen, additional, Skotnicka, Agnieszka, additional, Boyce, Andrea, additional, Donnelly, Anthony, additional, FitzGerald, Graham, additional, Dean, Victoria, additional, Warnes, Kristian, additional, Reyes, Anna, additional, Rahman, Saadia, additional, Tsang, Lillian, additional, Williams, Joanne, additional, Morris-Jones, Stephen, additional, Witness, Elen, additional, Brady, Orla, additional, Woodford, Elizabeth, additional, Pettifer, Teresa, additional, McCadden, Angela, additional, Marks, Ben, additional, Collier, Sophie, additional, Mack, Damien, additional, Warren, Simon, additional, Brown, Colin, additional, Lyons, Adrian, additional, Taiyari, Sara, additional, Mepham, Stephen, additional, Sweeney, Anna, additional, Brown, Li-An, additional, Potter, Alison, additional, Mandiza, Jess, additional, Hough, Maxine, additional, Williams, Sue, additional, Renton, Caroline, additional, Walters, Fiona, additional, Nadolski, Maria, additional, Evans, Andree, additional, Tarrant, Polly, additional, Curley, Katherine, additional, Whiteley, Sophie, additional, Halpin, Julia, additional, Hutchings, Melanie, additional, Todd, Shirley, additional, Lohan, Christop, additional, Chapter, Tamika, additional, Folland, Emma, additional, Colville, Alaric, additional, Marden, Katy, additional, Morgan, Marina, additional, Porter, Rob, additional, Baxter, Mel, additional, Rippon, Sarah, additional, Cevik, Muge, additional, Chapman, Judith, additional, Kemp, Tim, additional, Vincent, Rachel, additional, Osborne, Dave, additional, Platt, Tracey, additional, Calderwood, James, additional, Cook, Bernadette, additional, Bedford, Caroline, additional, Galloway-Browne, Leanne, additional, Abberley, Nadine, additional, Attack, Kelly, additional, Allen, Joanna, additional, Harrison, Melanie, additional, Stevenson, Sarah, additional, Brooks, Carol, additional, Harlow, Paula, additional, Ewing, Jordan, additional, Cooper, Shirley, additional, Balancio-Tolentino, Roderick, additional, O'Neil, Laura, additional, Tagney, Rebecca, additional, Shackcloth, Daniela, additional, Fellows, James, additional, Millett, Ruth, additional, Studham, Jo, additional, de Souza, Cherrelle, additional, Howell, Geoffrey, additional, Greaves, Hezron, additional, Foncel, Ella, additional, Kurup, Rahul, additional, Briggs, Jack, additional, Smith, Melody, additional, Suarez, Cristina, additional, Sorrentino, Giordana, additional, Scobie, Antonia, additional, Houston, Angela, additional, Ahmad, Fozia, additional, Breathnach, Aodhan, additional, Chahuan, Rakhee, additional, Wilkins, Katie, additional, Waddington, Natalia, additional, Sharma, Rashmi, additional, Flegg, Peter, additional, Kollipara, Veenu, additional, Alam, Mazhar, additional, Potter, Andrew, additional, Donaldson, Stacey, additional, Armer, Charlote, additional, Frudd, Julie, additional, Joy, Manju, additional, Mathews, Asha, additional, Glass, Stephen K, additional, Ajayi, Ayodele, additional, Fife, Amanda, additional, Qaiser, Saba, additional, Sheehan, Sharon, additional, Muñoz-Villaverde, Sergio, additional, Yogo, Noah, additional, De Abreu, Ines, additional, Notcheva, Gaynor, additional, Flanagan, Joanna, additional, Watson, Cordelia, additional, Sais, Efisia, additional, Adedayo, Adetunji, additional, Chu, Vicky, additional, Shaw, Georgina, additional, Graver, Michelle A, additional, Palmer, Rebecca, additional, Palmer, Donna, additional, Haile, Senait, additional, Gordon, Joanne, additional, Mandar, Kirandip, additional, Szypura, Weronika, additional, Marange, Josephine, additional, Shabangu, Vusumuzi, additional, Moore, Katy, additional, Lyons, Jill, additional, Munang, Melinda, additional, Sangombe, Mirriam, additional, Moran, Ed, additional, Hussain, Abid, additional, Lewszuk, Adam, additional, Batham, Sally, additional, Ellis, Kate, additional, Bahadur, Leila, additional, White, Helena, additional, Pareek, Manish, additional, Sahota, Amandip, additional, Coleman, Stephen, additional, Pateman, Hilary, additional, Kotecha, Atul, additional, Sim, Christopher, additional, Rosser, Andrew, additional, Deane, Jill, additional, Nendick, Richard, additional, Aldridge, Catherine, additional, Clarke, Anne, additional, Wood, Michelle, additional, Marshall, Adele, additional, Stephenson, Lynsey, additional, Matheson-Smith, Tracy, additional, Sloss, John, additional, Potts, Kathryn, additional, Malkin, Joanne, additional, Ftika, Lemonia, additional, Raviprakash, Veena, additional, Malachira, Ahalya, additional, Kean, Miranda, additional, Criste, Kristine, additional, Gladas, Kirsty, additional, Andrews, Caroline, additional, Hutchison, Clare, additional, Adams, Ellen, additional, Andrews, Janet, additional, Romans, Belinda, additional, Ridley, Nicola, additional, Ekani, Melanie, additional, Mitchell, Julie, additional, Smith, Nicola, additional, Clark, Tristan, additional, Glover, Sarah, additional, Reed, Robert, additional, Yam, Tat, additional, Burton, Holly, additional, Said, Rasha, additional, Janvier, Amy, additional, Jacob, Reni, additional, Smalley, Chris, additional, Fair, Alison, additional, Lord, Susan, additional, Ripalda, Kate, additional, Wooldridge, Helen, additional, Cotter, Luis, additional, Cardoso, Gus, additional, Strachan, Elaine, additional, Kaler, Gagan, additional, Mohamoodally, Adam, additional, Lawrence, Emma, additional, Prime, Zoe, additional, Abrahams, Rachel, additional, Price, David Ashley, additional, Rigden, Lesley, additional, Shewan, Laura, additional, Cullen, Katherine, additional, Emmerson, Ingrid, additional, Martin, Karen, additional, Wilson, Hesther, additional, Higham, Charley, additional, Taylor, Kathryn Louise, additional, Ong, Edmund, additional, Patel, Bijal, additional, Bond, Helena, additional, Gradwell, Janine, additional, Widdrington, John, additional, Thornthwaite, Sarah, additional, Prentice, Scott, additional, Poultney, Una, additional, Crowther, Hannah, additional, Fairlamb, Helen, additional, Hetherington, Emily, additional, Brewer, Chris, additional, Banerjee, Suryabrata, additional, Hamson, Clare, additional, McSkeane, Anna, additional, Sharratt, Paula, additional, Thorpe, Joanne, additional, Kimachia, Sue, additional, Wilson, Helen, additional, Jeffs, Benjamin, additional, Masters, Leslie, additional, Wilson, Jonathan, additional, Platt, Judith, additional, Burgess, Lisa, additional, Chadwick, Paul, additional, Jeans, Adam, additional, Keatley, Claire, additional, Moran, Amanda, additional, Swann, Zoe, additional, Pagett, Katherine, additional, Peel, Alex, additional, Howard, Jason, additional, Maloney, Kate, additional, Masdin, Avril, additional, Wright, Louise, additional, Crossman, Samantha, additional, Lowthorpe, Vicki, additional, Moore, Emma, additional, Moss, Peter, additional, Parkin, Angela, additional, Wolstencroft, Adam, additional, Warner, Bev, additional, Tarbotton, Clare, additional, Eyre, Alison, additional, Anderson, Anne, additional, Burdett, Tina, additional, Driffill, Amy, additional, Walker, Ann Sarah, additional, Szubert, Alex, additional, Webb, Helen, additional, Russell, Charlotte, additional, Jackson, Brooke, additional, Otiko, Damilola, additional, Borg, Chiara, additional, Masters, Lindsey, additional, Islam, Zaheer, additional, Díaz-Montaña, Carlos, additional, and Johnson, Debbie, additional

Published
2018
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15. Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa

Author

Hakim, James, primary, Musiime, Victor, additional, Szubert, Alex J., additional, Mallewa, Jane, additional, Siika, Abraham, additional, Agutu, Clara, additional, Walker, Simon, additional, Pett, Sarah L., additional, Bwakura-Dangarembizi, Mutsa, additional, Lugemwa, Abbas, additional, Kaunda, Symon, additional, Karoney, Mercy, additional, Musoro, Godfrey, additional, Kabahenda, Sheila, additional, Nathoo, Kusum, additional, Maitland, Kathryn, additional, Griffiths, Anna, additional, Thomason, Margaret J., additional, Kityo, Cissy, additional, Mugyenyi, Peter, additional, Prendergast, Andrew J., additional, Walker, A. Sarah, additional, and Gibb, Diana M., additional

Published
2017
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16. Adjunctive rifampicin for Staphylococcus aureusbacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial

Author

Thwaites, Guy E, Scarborough, Matthew, Szubert, Alexander, Nsutebu, Emmanuel, Tilley, Robert, Greig, Julia, Wyllie, Sarah A, Wilson, Peter, Auckland, Cressida, Cairns, Janet, Ward, Denise, Lal, Pankaj, Guleri, Achyut, Jenkins, Neil, Sutton, Julian, Wiselka, Martin, Armando, Gonzalez-Ruiz, Graham, Clive, Chadwick, Paul R, Barlow, Gavin, Gordon, N Claire, Young, Bernadette, Meisner, Sarah, McWhinney, Paul, Price, David A, Harvey, David, Nayar, Deepa, Jeyaratnam, Dakshika, Planche, Tim, Minton, Jane, Hudson, Fleur, Hopkins, Susan, Williams, John, Török, M Estee, Llewelyn, Martin J, Edgeworth, Jonathan D, Walker, A Sarah, Scarborough, Matthew, Kamfose, Musa, de Veciana, Ana, Gordon, Nicola Claire, Peto, Leon, Pill, Gemma, Clarke, Tiphanie, Watson, Laura, Young, Bernadette, Griffiths, Dai, Vaughn, Ali, Anson, Luke, Liu, Elian, Perera, Sanuki, Rylance-Knight, Lydia, Cantell, Carmen, Moroney, Ruth, Edgeworth, Jonathan D, Thwaites, Guy, Bisnauthsing, Karen, Querol-Rubiera, Antonio, Gibbs, Charlotte, Patel, Amita, Hemsley, Carolyn, Goodman, Anna L, Wyncoll, Duncan, Biswas, Jason, Fitzpatrick, Jennifer, Roberts, Lizzie, Millard, James, Stone, Neil, Cape, Angela, Hurley, Lisa, Tam, Chi Kai, Nsutebu, Emmanuel, Hoyle, Marie-Claire, Maitland, Kate, Trainor, Leona, Reynolds, Helen, Harrison, Jennifer, Anson, Jim, Lewis, Joseph, Folb, Jonathan, Goodwin, Lynsey, Beeching, Nicholas, Dyas, Sarah, Winslow, Helen, Foote, Elizabeth, Roberts, Paul, Natarajan, Pavithra, Chrdle, Alex, Fenech, Manuel, Allsop, Hannah, Tilley, Robert, Austin-Hutchison, Rachel, Barrett, Louise, Brookes, Karen, Carwithen, Leanne, Conbeer, Andrew, Cunningham, Richard, Eglinton, Charlotte, Fok, Rosie, Gott, Hannah, Hughes, Shona, Jones, Lewis, Kalita, Maggie, King, Angela, March, Linda, Marner, Mike, Mynes, Tracey, Plant, Aiden, Price, Suzanne, Sercombe, Judy, Stolton, Alison, Wallis, Mark, West, Marie-Claire, Westcott, Jackie, Williams, Claire, Wosley, Rob, Yabsley, Leona, Greig, Julia, Butland, Laura, Sorrell, Julie, Mitchell, Tamara, Alli, Abiola, Meiring, James, Masake, Boingotlo, Rowson, Carlene, Smart, Lynne, Makey, Laura, Moll, Sarah, Cunningham, Jane, Ryalls, Kim, Birchall, Kathryn, Middle, Janet, Jackson, Yvonne, Swift, Diane, Cole, Joby, Subramanian, Bala, Okhuoya, Faith, Edwards, Maria, Bailey, Cheryl, Warren, Rebecca, Islam, Gayti, Ankcorn, Michael, Birchall, Sarah, Jones, Paul, Humphries, John, Booth, Stephen, Evan, Cariad, Wyllie, Sarah, Flatt, Andrew, Strakova, Lenka, Hayes, Maria, Valentine, Stacey, James, Clare, Wands, Mary, Cortes, Nicolas, Khan, Nisa, Porter, Robert, Martin, Zoe, Yip, Keith, Preedy, Helen, Chesterfield, Helen, Dobson, Tracey, Walker, Colin, Llewelyn, Martin, Dunne, Angela, Latter, Laura, Porges, Alison, Price, James, Paul, John, Behar, Laura, Robinson, Louise, Murray, Amy, Fitzpatrick, Jennifer, Sargent, Tenessa, Ridley, Carrie, de Gordoa, Laura Ortiz-Ruiz, Gilliam, Deborah, McPherson, Carole, Matthews, Simon, Foreman, Emma, Jarghese, Rajesh, Beddoe, Alisha, Martin, Sebastien, Shaw, Sephora, Wlazly, Dominika, Cole, Maggie, Gihawi, Abraham, Cole, Kevin, Török, M Estée, Gouliouris, Theodore, Bedford, Luke, Saunderson, Rebecca B, Mariolis, Ilias, Bousfield, Rachel, Ramsay, Isobel, Greaves, Daniel, Aliyu, Sani, Cox, Kim, Mlemba, Lois, Whitehead, Lynne, Vyse, Naval, Bolton, Mark, Williams, John, Lambert, Pauline, Chadwick, David, Baillie, Kirsty, Cain, Martyn, Bellamy, Richard, Wong, Jason, Thompson, Jane, Vassallo, Helen, Skotnicka, Agnieszka, Boyce, Andrea, Donnelly, Anthony, Wilson, Peter, FitzGerald, Graham, Dean, Victoria, Warnes, Kristian, Reyes, Anna, Rahman, Saadia, Tsang, Lillian, Williams, Joanne, Morris-Jones, Stephen, Hopkins, Susan, Witness, Elen, Brady, Orla, Woodford, Elizabeth, Pettifer, Teresa, McCadden, Angela, Marks, Ben, Collier, Sophie, Mack, Damien, Warren, Simon, Brown, Colin, Lyons, Adrian, Taiyari, Sara, Mepham, Stephen, Sweeney, Anna, Brown, Li-An, Auckland, Cressida, Potter, Alison, Mandiza, Jess, Hough, Maxine, Williams, Sue, Renton, Caroline, Walters, Fiona, Nadolski, Maria, Evans, Andree, Tarrant, Polly, Curley, Katherine, Whiteley, Sophie, Halpin, Julia, Hutchings, Melanie, Todd, Shirley, Lohan, Christop, Chapter, Tamika, Folland, Emma, Colville, Alaric, Marden, Katy, Morgan, Marina, Fok, Rosie, Porter, Rob, Baxter, Mel, Minton, Jane, Rippon, Sarah, Cevik, Muge, Chapman, Judith, Kemp, Tim, Vincent, Rachel, Osborne, Dave, Platt, Tracey, Calderwood, James, Cook, Bernadette, Bedford, Caroline, Galloway-Browne, Leanne, Abberley, Nadine, Attack, Kelly, Allen, Joanna, Lal, Pankaj, Harrison, Melanie, Stevenson, Sarah, Brooks, Carol, Harlow, Paula, Ewing, Jordan, Cooper, Shirley, Balancio-Tolentino, Roderick, O'Neil, Laura, Tagney, Rebecca, Shackcloth, Daniela, Planche, Tim, Fellows, James, Millett, Ruth, Studham, Jo, de Souza, Cherrelle, Howell, Geoffrey, Greaves, Hezron, Foncel, Ella, Kurup, Rahul, Briggs, Jack, Smith, Melody, Suarez, Cristina, Sorrentino, Giordana, Scobie, Antonia, Houston, Angela, Ahmad, Fozia, Breathnach, Aodhan, Chahuan, Rakhee, Wilkins, Katie, Guleri, Achyut, Waddington, Natalia, Sharma, Rashmi, Flegg, Peter, Kollipara, Veenu, Alam, Mazhar, Potter, Andrew, Donaldson, Stacey, Armer, Charlote, Frudd, Julie, Jeyaratnam, Dakshika, Joy, Manju, Mathews, Asha, Glass, Stephen K, Ajayi, Ayodele, Fife, Amanda, Qaiser, Saba, Sheehan, Sharon, Muñoz-Villaverde, Sergio, Yogo, Noah, De Abreu, Ines, Notcheva, Gaynor, Flanagan, Joanna, Watson, Cordelia, Sais, Efisia, Adedayo, Adetunji, Chu, Vicky, Shaw, Georgina, Graver, Michelle A, Palmer, Rebecca, Palmer, Donna, Haile, Senait, Gordon, Joanne, Tam, Chi Kai, Mandar, Kirandip, Szypura, Weronika, Jenkins, Neil, Marange, Josephine, Shabangu, Vusumuzi, Moore, Katy, Lyons, Jill, Munang, Melinda, Sangombe, Mirriam, Moran, Ed, Hussain, Abid, Wiselka, Martin, Lewszuk, Adam, Batham, Sally, Ellis, Kate, Bahadur, Leila, White, Helena, Pareek, Manish, Sahota, Amandip, Coleman, Stephen, Pateman, Hilary, Kotecha, Atul, Sim, Christopher, Rosser, Andrew, Deane, Jill, Nendick, Richard, Aldridge, Catherine, Clarke, Anne, Wood, Michelle, Marshall, Adele, Stephenson, Lynsey, Matheson-Smith, Tracy, Sloss, John, Potts, Kathryn, Malkin, Joanne, Ftika, Lemonia, Raviprakash, Veena, Sutton, Julian, Malachira, Ahalya, Kean, Miranda, Criste, Kristine, Gladas, Kirsty, Andrews, Caroline, Hutchison, Clare, Adams, Ellen, Andrews, Janet, Romans, Belinda, Ridley, Nicola, Ekani, Melanie, Mitchell, Julie, Smith, Nicola, Clark, Tristan, Glover, Sarah, Reed, Robert, Yam, Tat, Burton, Holly, Said, Rasha, Harvey, David, Janvier, Amy, Jacob, Reni, Smalley, Chris, Fair, Alison, Lord, Susan, Ripalda, Kate, Wooldridge, Helen, Cotter, Luis, Cardoso, Gus, Strachan, Elaine, Kaler, Gagan, Mohamoodally, Adam, Lawrence, Emma, Prime, Zoe, Abrahams, Rachel, Price, David Ashley, Rigden, Lesley, Shewan, Laura, Cullen, Katherine, Emmerson, Ingrid, Martin, Karen, Wilson, Hesther, Higham, Charley, Taylor, Kathryn Louise, Ong, Edmund, Patel, Bijal, Bond, Helena, Gradwell, Janine, Widdrington, John, Graham, Clive, Thornthwaite, Sarah, Prentice, Scott, Poultney, Una, Crowther, Hannah, Fairlamb, Helen, Hetherington, Emily, Brewer, Chris, Banerjee, Suryabrata, Hamson, Clare, McSkeane, Anna, McWhinney, Paul, Sharratt, Paula, Thorpe, Joanne, Kimachia, Sue, Wilson, Helen, Jeffs, Benjamin, Masters, Leslie, Wilson, Jonathan, Platt, Judith, Burgess, Lisa, Chadwick, Paul, Jeans, Adam, Keatley, Claire, Moran, Amanda, Swann, Zoe, Pagett, Katherine, Peel, Alex, Howard, Jason, Meisner, Sarah, Maloney, Kate, Masdin, Avril, Wright, Louise, Barlow, Gavin, Crossman, Samantha, Lowthorpe, Vicki, Moore, Emma, Moss, Peter, Parkin, Angela, Wolstencroft, Adam, Warner, Bev, Tarbotton, Clare, Eyre, Alison, Anderson, Anne, Burdett, Tina, Driffill, Amy, Walker, Ann Sarah, Hudson, Fleur, Szubert, Alex, Cairns, Janet, Ward, Denise, Webb, Helen, Russell, Charlotte, Jackson, Brooke, Otiko, Damilola, Borg, Chiara, Masters, Lindsey, Islam, Zaheer, Díaz-Montaña, Carlos, and Johnson, Debbie

Abstract

Staphylococcus aureusbacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureuskilling, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection.

Published
2018
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17. Sequential Immunomodulatory Drug (IMiD) and Proteosome Inhibitor Therapy Improves Response Rates in Newly Diagnosed Multiple Myeloma: Preliminary Results From the Myeloma XI Trial

Author

Pawlyn, Charlotte, primary, Davies, Faith E., additional, Gregory, Walter M, additional, Szubert, Alex J, additional, Bell, Sue E, additional, Ouzman, Jacqueline, additional, Drayson, Mark T, additional, Owen, Roger G, additional, Jackson, Graham H, additional, Russell, Nigel H, additional, and Morgan, Gareth J., additional

Published
2012
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18. MRC Myeloma IX, 6 Year Median Follow-up (FU) Highlights the Importance of Long-Term FU in Myeloma Clinical Trials and Differential Effects of Thalidomide in High- and Low-Risk Disease

Author

Morgan, Gareth J, primary, Davies, Faith E, additional, Gregory, Walter M, additional, Bell, Sue E, additional, Szubert, Alex J, additional, Cook, Gordon, additional, Drayson, Mark T, additional, Owen, Roger G, additional, Ross, Fiona M, additional, Jackson, Graham H, additional, and Child, J. Anthony, additional

Published
2011
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20. Gender Disparities in the Tumor Genetics and Clinical Outcome of Multiple Myeloma

Author

Boyd, Kevin D., primary, Ross, Fiona M., additional, Chiecchio, Laura, additional, Dagrada, GianPaolo, additional, Konn, Zoe J., additional, Tapper, William J., additional, Walker, Brian A., additional, Wardell, Christopher P., additional, Gregory, Walter M., additional, Szubert, Alex J., additional, Davies, Faith E., additional, and Morgan, Gareth J., additional

Published
2011
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21. Heterogeneity in the Prognostic Significance of 12p Deletion and Chromosome 5 Amplification in Multiple Myeloma

Author

Tapper, William, primary, Chiecchio, Laura, additional, Dagrada, Gian Paolo, additional, Konn, Zoe J., additional, Stockley, David M., additional, Szubert, Alex J., additional, Gregory, Walter M., additional, Bell, Susan E., additional, Jackson, Graham H., additional, Child, J. Anthony, additional, Morgan, Gareth J., additional, and Ross, Fiona M., additional

Published
2011
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22. Thalidomide Maintenance Significantly Improves Progression-Free Survival (PFS) and Overall Survival (OS) of Myeloma Patients When Effective Relapse Treatments Are Used: MRC Myeloma IX Results

Author

Morgan, Gareth J, primary, Davies, Faith E., additional, Gregory, Walter M., additional, Bell, Sue E., additional, Szubert, Alex J., additional, Navarro-Coy, Nuria, additional, Drayson, Mark T., additional, Owen, Roger G., additional, Cook, Gordon, additional, Ross, Fiona M., additional, Jackson, Graham H., additional, and Child, J. Anthony, additional

Published
2010
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24. The Addition of Thalidomide to the Induction Treatment of Newly Presenting Myeloma Patients Increases the CR Rate Which Is Likely to Translate Into Improved PFS and OS.

Author

Morgan, Gareth J, primary, Davies, Faith E, additional, Gregory, Walter M, additional, Bell, Susan E, additional, Szubert, Alex J, additional, Cocks, Kim, additional, Coy, Nuria Navarro, additional, Drayson, Mark T, additional, Owen, Roger G, additional, Ross, Fiona M, additional, Jackson, Graham H, additional, and Child, J. Anthony, additional

Published
2009
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26. Maintenance Thalidomide May Improve Progression Free but Not Overall Survival; Results from the Myeloma IX Maintenance Randomisation

Author

Morgan, Gareth J, primary, Jackson, Graham H, additional, Davies, Faith E, additional, Drayson, Mark T, additional, Owen, Roger G, additional, Gregory, Walter M, additional, Cohen, Dena C, additional, Szubert, Alex J., additional, Bell, Susan E, additional, Ross, Fiona, additional, and Child, James A, additional

Published
2008
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28. The t(14;20) is a poor prognostic factor in myeloma but is associated with long-term stable disease in monoclonal gammopathies of undetermined significance.

Author

Ross FM, Chiecchio L, Dagrada G, Protheroe RK, Stockley DM, Harrison CJ, Cross NC, Szubert AJ, Drayson MT, and Morgan GJ

Subjects
Adult, Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male, Middle Aged, Monoclonal Gammopathy of Undetermined Significance diagnosis, Multiple Myeloma diagnosis, Prognosis, Monoclonal Gammopathy of Undetermined Significance genetics, Multiple Myeloma genetics, Translocation, Genetic
Abstract

A large series of plasma cell dyscrasias (n=2207) was examined for translocations which deregulate the MAF genes, t(14;20)(q32;q12) and t(14;16)(q32;q23), and their disease behavior was compared to a group characterized by the t(4;14)(p16;q32) where CCND2 is also up-regulated. The t(14;20) showed low prevalence in myeloma (27/1830, 1.5%) and smoldering myeloma (1/148, <1%) with a higher incidence in MGUS (9/193, 5% P=0.005). Strong associations with del(13) (76%), non-hyperdiploidy (83%) and gain of 1q (58%) were seen but no association with an IgA M-protein or absence of bone disease was noted. All three translocations were associated with poor outcome in myeloma, but strikingly all t(14;20) MGUS/smoldering myeloma cases (n=10) had stable, low level disease. In contrast, the 10 t(14;16) and 25 t(4;14) MGUS/smoldering myeloma cases were associated with both evolving and non-evolving disease. None of the associated genetic abnormalities helped to predict for progression from MGUS or smoldering myeloma.

Published
2010
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