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Adjunctive rifampicin for Staphylococcus aureusbacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial
Authors :
Thwaites, Guy E Scarborough, Matthew Szubert, Alexander Nsutebu, Emmanuel Tilley, Robert Greig, Julia Wyllie, Sarah A Wilson, Peter Auckland, Cressida Cairns, Janet Ward, Denise Lal, Pankaj Guleri, Achyut Jenkins, Neil Sutton, Julian Wiselka, Martin Armando, Gonzalez-Ruiz Graham, Clive Chadwick, Paul R Barlow, Gavin Gordon, N Claire Young, Bernadette Meisner, Sarah McWhinney, Paul Price, David A Harvey, David Nayar, Deepa Jeyaratnam, Dakshika Planche, Tim Minton, Jane Hudson, Fleur Hopkins, Susan Williams, John Török, M Estee Llewelyn, Martin J Edgeworth, Jonathan D Walker, A Sarah Scarborough, Matthew Kamfose, Musa de Veciana, Ana Gordon, Nicola Claire Peto, Leon Pill, Gemma Clarke, Tiphanie Watson, Laura Young, Bernadette Griffiths, Dai Vaughn, Ali Anson, Luke Liu, Elian Perera, Sanuki Rylance-Knight, Lydia Cantell, Carmen Moroney, Ruth Edgeworth, Jonathan D Thwaites, Guy Bisnauthsing, Karen Querol-Rubiera, Antonio Gibbs, Charlotte Patel, Amita Hemsley, Carolyn Goodman, Anna L Wyncoll, Duncan Biswas, Jason Fitzpatrick, Jennifer Roberts, Lizzie Millard, James Stone, Neil Cape, Angela Hurley, Lisa Tam, Chi Kai Nsutebu, Emmanuel Hoyle, Marie-Claire Maitland, Kate Trainor, Leona Reynolds, Helen Harrison, Jennifer Anson, Jim Lewis, Joseph Folb, Jonathan Goodwin, Lynsey Beeching, Nicholas Dyas, Sarah Winslow, Helen Foote, Elizabeth Roberts, Paul Natarajan, Pavithra Chrdle, Alex Fenech, Manuel Allsop, Hannah Tilley, Robert Austin-Hutchison, Rachel Barrett, Louise Brookes, Karen Carwithen, Leanne Conbeer, Andrew Cunningham, Richard Eglinton, Charlotte Fok, Rosie Gott, Hannah Hughes, Shona Jones, Lewis Kalita, Maggie King, Angela March, Linda Marner, Mike Mynes, Tracey Plant, Aiden Price, Suzanne Sercombe, Judy Stolton, Alison Wallis, Mark West, Marie-Claire Westcott, Jackie Williams, Claire Wosley, Rob Yabsley, Leona Greig, Julia Butland, Laura Sorrell, Julie Mitchell, Tamara Alli, Abiola Meiring, James Masake, Boingotlo Rowson, Carlene Smart, Lynne Makey, Laura Moll, Sarah Cunningham, Jane Ryalls, Kim Birchall, Kathryn Middle, Janet Jackson, Yvonne Swift, Diane Cole, Joby Subramanian, Bala Okhuoya, Faith Edwards, Maria Bailey, Cheryl Warren, Rebecca Islam, Gayti Ankcorn, Michael Birchall, Sarah Jones, Paul Humphries, John Booth, Stephen Evan, Cariad Wyllie, Sarah Flatt, Andrew Strakova, Lenka Hayes, Maria Valentine, Stacey James, Clare Wands, Mary Cortes, Nicolas Khan, Nisa Porter, Robert Martin, Zoe Yip, Keith Preedy, Helen Chesterfield, Helen Dobson, Tracey Walker, Colin Llewelyn, Martin Dunne, Angela Latter, Laura Porges, Alison Price, James Paul, John Behar, Laura Robinson, Louise Murray, Amy Fitzpatrick, Jennifer Sargent, Tenessa Ridley, Carrie de Gordoa, Laura Ortiz-Ruiz Gilliam, Deborah McPherson, Carole Matthews, Simon Foreman, Emma Jarghese, Rajesh Beddoe, Alisha Martin, Sebastien Shaw, Sephora Wlazly, Dominika Cole, Maggie Gihawi, Abraham Cole, Kevin Török, M Estée Gouliouris, Theodore Bedford, Luke Saunderson, Rebecca B Mariolis, Ilias Bousfield, Rachel Ramsay, Isobel Greaves, Daniel Aliyu, Sani Cox, Kim Mlemba, Lois Whitehead, Lynne Vyse, Naval Bolton, Mark Williams, John Lambert, Pauline Chadwick, David Baillie, Kirsty Cain, Martyn Bellamy, Richard Wong, Jason Thompson, Jane Vassallo, Helen Skotnicka, Agnieszka Boyce, Andrea Donnelly, Anthony Wilson, Peter FitzGerald, Graham Dean, Victoria Warnes, Kristian Reyes, Anna Rahman, Saadia Tsang, Lillian Williams, Joanne Morris-Jones, Stephen Hopkins, Susan Witness, Elen Brady, Orla Woodford, Elizabeth Pettifer, Teresa McCadden, Angela Marks, Ben Collier, Sophie Mack, Damien Warren, Simon Brown, Colin Lyons, Adrian Taiyari, Sara Mepham, Stephen Sweeney, Anna Brown, Li-An Auckland, Cressida Potter, Alison Mandiza, Jess Hough, Maxine Williams, Sue Renton, Caroline Walters, Fiona Nadolski, Maria Evans, Andree Tarrant, Polly Curley, Katherine Whiteley, Sophie Halpin, Julia Hutchings, Melanie Todd, Shirley Lohan, Christop Chapter, Tamika Folland, Emma Colville, Alaric Marden, Katy Morgan, Marina Fok, Rosie Porter, Rob Baxter, Mel Minton, Jane Rippon, Sarah Cevik, Muge Chapman, Judith Kemp, Tim Vincent, Rachel Osborne, Dave Platt, Tracey Calderwood, James Cook, Bernadette Bedford, Caroline Galloway-Browne, Leanne Abberley, Nadine Attack, Kelly Allen, Joanna Lal, Pankaj Harrison, Melanie Stevenson, Sarah Brooks, Carol Harlow, Paula Ewing, Jordan Cooper, Shirley Balancio-Tolentino, Roderick O'Neil, Laura Tagney, Rebecca Shackcloth, Daniela Planche, Tim Fellows, James Millett, Ruth Studham, Jo de Souza, Cherrelle Howell, Geoffrey Greaves, Hezron Foncel, Ella Kurup, Rahul Briggs, Jack Smith, Melody Suarez, Cristina Sorrentino, Giordana Scobie, Antonia Houston, Angela Ahmad, Fozia Breathnach, Aodhan Chahuan, Rakhee Wilkins, Katie Guleri, Achyut Waddington, Natalia Sharma, Rashmi Flegg, Peter Kollipara, Veenu Alam, Mazhar Potter, Andrew Donaldson, Stacey Armer, Charlote Frudd, Julie Jeyaratnam, Dakshika Joy, Manju Mathews, Asha Glass, Stephen K Ajayi, Ayodele Fife, Amanda Qaiser, Saba Sheehan, Sharon Muñoz-Villaverde, Sergio Yogo, Noah De Abreu, Ines Notcheva, Gaynor Flanagan, Joanna Watson, Cordelia Sais, Efisia Adedayo, Adetunji Chu, Vicky Shaw, Georgina Graver, Michelle A Palmer, Rebecca Palmer, Donna Haile, Senait Gordon, Joanne Tam, Chi Kai Mandar, Kirandip Szypura, Weronika Jenkins, Neil Marange, Josephine Shabangu, Vusumuzi Moore, Katy Lyons, Jill Munang, Melinda Sangombe, Mirriam Moran, Ed Hussain, Abid Wiselka, Martin Lewszuk, Adam Batham, Sally Ellis, Kate Bahadur, Leila White, Helena Pareek, Manish Sahota, Amandip Coleman, Stephen Pateman, Hilary Kotecha, Atul Sim, Christopher Rosser, Andrew Deane, Jill Nendick, Richard Aldridge, Catherine Clarke, Anne Wood, Michelle Marshall, Adele Stephenson, Lynsey Matheson-Smith, Tracy Sloss, John Potts, Kathryn Malkin, Joanne Ftika, Lemonia Raviprakash, Veena Sutton, Julian Malachira, Ahalya Kean, Miranda Criste, Kristine Gladas, Kirsty Andrews, Caroline Hutchison, Clare Adams, Ellen Andrews, Janet Romans, Belinda Ridley, Nicola Ekani, Melanie Mitchell, Julie Smith, Nicola Clark, Tristan Glover, Sarah Reed, Robert Yam, Tat Burton, Holly Said, Rasha Harvey, David Janvier, Amy Jacob, Reni Smalley, Chris Fair, Alison Lord, Susan Ripalda, Kate Wooldridge, Helen Cotter, Luis Cardoso, Gus Strachan, Elaine Kaler, Gagan Mohamoodally, Adam Lawrence, Emma Prime, Zoe Abrahams, Rachel Price, David Ashley Rigden, Lesley Shewan, Laura Cullen, Katherine Emmerson, Ingrid Martin, Karen Wilson, Hesther Higham, Charley Taylor, Kathryn Louise Ong, Edmund Patel, Bijal Bond, Helena Gradwell, Janine Widdrington, John Graham, Clive Thornthwaite, Sarah Prentice, Scott Poultney, Una Crowther, Hannah Fairlamb, Helen Hetherington, Emily Brewer, Chris Banerjee, Suryabrata Hamson, Clare McSkeane, Anna McWhinney, Paul Sharratt, Paula Thorpe, Joanne Kimachia, Sue Wilson, Helen Jeffs, Benjamin Masters, Leslie Wilson, Jonathan Platt, Judith Burgess, Lisa Chadwick, Paul Jeans, Adam Keatley, Claire Moran, Amanda Swann, Zoe Pagett, Katherine Peel, Alex Howard, Jason Meisner, Sarah Maloney, Kate Masdin, Avril Wright, Louise Barlow, Gavin Crossman, Samantha Lowthorpe, Vicki Moore, Emma Moss, Peter Parkin, Angela Wolstencroft, Adam Warner, Bev Tarbotton, Clare Eyre, Alison Anderson, Anne Burdett, Tina Driffill, Amy Walker, Ann Sarah Hudson, Fleur Szubert, Alex Cairns, Janet Ward, Denise Webb, Helen Russell, Charlotte Jackson, Brooke Otiko, Damilola Borg, Chiara Masters, Lindsey Islam, Zaheer Díaz-Montaña, Carlos Johnson, Debbie
Source :
The Lancet; February 2018, Vol. 391 Issue: 10121 p668-678, 11p
Publication Year :
2018
Abstract
Staphylococcus aureusbacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureuskilling, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
391
Issue :
10121
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs44814823
Full Text :
https://doi.org/10.1016/S0140-6736(17)32456-X