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59 results on '"Système Nerveux Autonome, Epidémiologie, Physiologie, Ingénierie, Santé (SNA- EPIS)"'

1. Automated Coding in Case Mix Databases of Bacterial Infections Based on Antimicrobial Susceptibility Test Results

Author: Radia Spiga, François-Elie Calvier, Anne Carricajo, Bruno Pozzetto, Béatrice Trombert-Paviot, Cédric Bousquet, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Institut Henri Fayol (FAYOL-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Département Génie mathématique et industriel (FAYOL-ENSMSE), Ecole Nationale Supérieure des Mines de St Etienne-Institut Henri Fayol, Commission Spécialisée Maladies infectieuses et maladies émergentes (CSMime), Haut Conseil de la Santé Publique (HCSP), Service de santé publique et d'information médicale [CHU Saint-Etienne] (SSPIM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, Breuil, Florent, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Institut Henri Fayol, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), and Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS)
Subjects: Bacteria, Clinical Coding, Electronic Health Records, Health care payment system, France, [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Abstract: International audience; Our objective was to improve the accuracy of bacteria and resistance coding in a hospital case mix database. Data sources consisted of 50,074 files on bacteriological susceptibility tests transmitted with the HPRIM protocol from laboratory management system to electronic health record of the University hospital of Saint Etienne in July 2017. An algorithm was implemented to detect susceptibility tests containing information corresponding to codes whose addition in the case mix database was susceptible to increase the severity level of a diagnosis related group. Among 132 hospital stays fulfilling the conditions, 27 were lacking bacteria and/or resistance codes, and the tariff was increased for 9 stays, with earnings of €54,612. Analyzing Antimicrobial susceptibility tests helps to improve clinical coding and optimize the financial gain.
Published: 2022
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2. Care through cohort studies: sociological survey of the PROOF cohort study on vascular and cognitive aging

Author: Thomas Bujon, Vololona Rabeharisoa, Frédéric Roche, Rodolphe Charles, Jean-Claude Barthélémy, Angélique Savall, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Université Jean Monnet [Saint-Étienne] (UJM), Triangle : action, discours, pensée politique et économique (TRIANGLE), Centre National de la Recherche Scientifique (CNRS)-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Centre de Sociologie de l'Innovation i3 (CSI i3), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Université Jean Monnet - Saint-Étienne (UJM), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut interdisciplinaire de l’innovation (I3), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
Subjects: Cognitive aging, Gerontology, Aging, research ethics, Participant observation, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Humans, 030212 general & internal medicine, Research ethics, [SHS.SOCIO]Humanities and Social Sciences/Sociology, 030505 public health, human experimentation, Public Health, Environmental and Occupational Health, Medical safety, General Medicine, care : cohort studies, Research Personnel, Cognitive Aging, Cohort, Research studies, 0305 other medical science, Qualitative research, Cohort study
Abstract: Background The success of health research depends on the involvement of participants. Few studies have examined the participation of subjects in cohorts. Drawing on a sociological survey on a French cohort around aging, this study proposes to question the nature of interactions between researchers and subjects that would help to understand the motivations of subjects to participate and remain in health research studies. Methods Qualitative study combining participant observation within the research laboratory that conducted the cohort and semi-structured interviews with subjects included in the cohort and with members of the research team. Results This study highlights the existence of two-way care: from the laboratory to the subjects and from the cohort to researchers. Health research seems to correspond to a complex association between subjects concerned with aging and the expected benefits of exceptional monitoring. Research is incorporated into subjects’ daily lives, allowing a shift in the purpose of research from overmedicalization to medical safety that subjects experienced as a form of care. Conclusions In cohort studies, care is understood as a form of attention to the person through high-quality medical follow-up. Aging is turned into a matter of concern that subjects, in collaboration with researchers, strive to control.
Published: 2020
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3. Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units

Author: Sylvie Joron, Stéphane Marret, Fabrice Lapeyre, Jérôme Larche, Jacqueline Grando, David Leyssene, Jean Nakhleh, Clarisse Dupin, Tania Foucan, Stéphanie Bordes-Couecou, Géraldine Abadie, Franck Labbe, Marie Kempf, Manuel Petitfrere, Audrey Robine, Marie Decalonne, Chantal Chaplain, Philippe Jouvencel, Florent Goube, Benjamin Cotte, Laurent Villeneuve, Adeline Lacazette, Raoul Baron, Jean-Marc Jellimann, Anne-Sophie Trentesaux, Nathalie Chautemps, Laurent Mereghetti, Olivier Dauwalder, Nicolas Fortineau, Christine Roques Ceschin, Rafik Ben Ammar, Sandra Bourdon, Alain Gravet, Audrey Glanard, Olivier Belmonte, Jacques Gilquin, Arnaud Florentin, Souad Slimani, Annick Lefebvre, Jérôme Guinard, Edith Malpote, Céline Chatelet, Isabelle Bauvin, Alain Lozniewski, Anaëlle Muggeo, Geneviève Héry-Arnaud, Stéphane Le Vu, Isabelle Ligi, Anne Le Pourhiennec, Christian Cattoen, Olivier Join-Lambert, Bruno Pozetto, Carole De Chillaz, Amine Siali, Pascale Martres, Michel Drancourt, Claire Lesteven, Sandra C. dos Santos, Nadège Bourgeois-Nicolaos, Aude Davy, Claude Olive, Rémi Gimenes, Laure Gibert, Raymond Ruimy, Virginie Morange, Antoine Bouissou, Julien Mourdie, Emmanuelle Bille, Marie-Noëlle Noulard, Vincent Cattoir, Martine Delorme, Dominique Trivier, Luc Desfrere, Hugues Patural, Patrick Barthelemy, Nadia Idri, Florence Lemann, Franck-Olivier Mallaval, Sophie Ketterer-Martinon, Christian Vandenbussche, Pierre Frange, Sylvie Ledru, Mouna Khecharem, Pierre Lureau, Sophie Boyer, Philippe Berthelot, Salma Ben Hadj Yahia, Clément Legeay, Emilie Benabid, Guillaume Menard, Marion Levast-Raffin, Céline Coroller-Bec, Claire Huart, Maryvonne Demasure, Pascal Bolot, Yasmina Berrouane, Hélène Cormier, Pascale Minery, Pascale Penn, Peggy Larroude, Evelyne Werner, Géraldine Gascoin, Virginie Forget, Nathalie van der Mee-Marquet, Stéphanie Soive, Karine Gambarotto, Vanina Ambrogi, Aurore Claudinon, Serge Klosowski, Brigitte Riviere, Véronique Merle, Laura Menvielle, Véronique Faraut-Derouin, Saïd Aberrane, Alain Beuchee, Nolwenn Le Sache, Hôpital Bretonneau, CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion], Centre Hospitalier René Dubos [Pontoise], Centre Hospitalier Intercommunal de Créteil (CHIC), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre hospitalier de Pau, Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier de Calais, Centre Hospitalier Universitaire de Nice (CHU Nice), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), CHU Pontchaillou [Rennes], Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier de Saint-Denis [Ile-de-France], Centre Hospitalier de la Côte Basque (CHCB), Groupe Hospitalier du Havre, Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Centre hospitalier [Valenciennes, Nord], Centre Hospitalier Universitaire [Rennes], GHT de l'Artois, Centre Hospitalier Victor Dupouy, Centre Hospitalier Métropole Savoie [Chambéry], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Le Mans (CH Le Mans), Clinique du Val d'Ouest, CHU Necker - Enfants Malades [AP-HP], Hospices Civils de Lyon (HCL), Centre hospitalier Saint-Brieuc, Centre Hospitalier Georges Renon [Niort] (CH Georges Renon Niort), Centre Hospitalier Régional d'Orléans (CHRO), Hôpital Louis Mourier - AP-HP [Colombes], Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), CHU de Saint-Brieuc, Interactions Gènes-Risques environnementaux et Effets sur la Santé (INGRES), Université de Lorraine (UL), Unité de Recherche Environnement Physique de la plante Horticole (EPHOR), Université d'Angers (UA)-AGROCAMPUS OUEST, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Hôpital Hôtel-Dieu [Paris], Hôpital Delafontaine, Centre Hospitalier de Mulhouse, site du Hasenrain (Mulhouse), Laboratoire Universitaire de Biodiversité et Ecologie Microbienne (LUBEM), Université de Brest (UBO), Service de réanimation néonatale [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Pathogénie des infections systémiques (UMR_S 570), Centre Régional de PharmacoVigilance Nord-Pas-de-Calais [CHU Lille] (CRPV), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Faculté de Médecine Henri Warembourg - Université de Lille, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), CHU de la Martinique [Fort de France], Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) (GHH), Polyclinique Médipôle Saint-Roch [Cabestany], Centre Hospitalier Universitaire de Reims (CHU Reims), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Université d'Auvergne - Clermont-Ferrand I (UdA), Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), Service de microbiologie [CHU Nancy], Service psychiatrique de l'enfant et de l'adolescent [CHU Hôpital Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Service de bactériologie-virologie [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, Infectiologie et Santé Publique (UMR ISP), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Registre EPIMAD, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Pathogénie des Staphylocoques – Staphylococcal Pathogenesis (StaPath), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), ELSAN Polyclinique Majorelle, Centre Hospitalier Intercommunal Castres-Mazamet (CHIC-CM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Centre Hospitalier de Lens, Institut de Veille Sanitaire (INVS), Hôpital Trousseau, Jonchère, Laurent, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Le CHCB, Centre Hospitalier de la Côte Basque, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, CHU Saint-Etienne, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université Lille 2 - Faculté de Médecine, Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Amiens-Picardie, Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, CHU Toulouse [Toulouse], Centre Hospitalier Universitaire Félix-Guyon [Saint-Denis, La Réunion, France], Centre Hospitalier Universitaire de Toulouse, Department of Microbiology Brest, Department of Microbiology, Brest, CHU CLAMART, Centre Hospitalier Universitaire de Nice (CHU de Nice), Centre Hospitalier Côte Basque, Bayonne, CHU Le Havre, Laboratory of microbiology and infection control, Assistance publique-Hôpitaux de Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire Charles Nicolle, Partenaires INRAE, CHU de la Réunion, Saint-Denis, France., CHU Lens, CHU Argenteuil, Centre Hospitalier Métropole Savoie-Site de Chambéry, La Clinique du Val d'Ouest, Hôpitaux Est Hôpital Louis Pradel - Hospices Civils de Lyon, Centre Hospitalier Régional d'Orléans (CHR), Hopital Louis Mourier - AP-HP [Colombes], Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Service de virologie, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes], Hôpital Antoine Béclère, Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Bactériologie-Virologie, Hôpital Bretonneau-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre d'infectiologie Necker-Pasteur [CHU Necker], Service de chirurgie infantile, CHU Felix Guyon, Saint Denis de La Réunion, Hôtel-Dieu, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu, Unité d'Hygiène Hospitalière, hospices civils de Lyon, Hôpital du Hasenrain, Mulhouse, CHU Valenciennes, Université Henri Poincaré - Nancy 1 (UHP), Hôpital de Bayonne [Bayonne], CHU Kremlin-Bicétre, Anofel Cryptosporidium National Network, Polyclinique de St Roch, CHU Pau, Unité de prévention et de lutte contre les infections nosocomiales [CHU Angers], PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Division of Neonatology, La Conception Hospital, Assistance Publique-Hôpitaux de Marseille and Faculté de Médecine, Université de la Méditerranée - Aix-Marseille 2, Laboratoire de Microbiologie clinique et environnementale [Pointe-à-Pitre, Guadeloupe, France], Centre Hospitalier Universitaire de Rennes (CHU Rennes), Hôpital privé de l'Estuaire [Le Havre], Pathogénie des Staphylocoques – Staphylococcal Pathogenesis, Hôpital d'Arras, CHU Le MAns, Polyclinique Majorelle, Laboratoire de Microbiologie, Centre Hospitalier Intercommunal Castres-Mazamet, Laboratoire de bactériologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Recherche Opérationnelle et Mathématiques de la Décision - LAROMAD (Alger, Algérie), Centre Hospitalier d’Arras, Unité de Méthodologie en Recherche Clinique, Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)
Subjects: Male, 0301 basic medicine, Pediatrics, Clone (cell biology), NRCS-A clone, 030501 epidemiology, Staphylococcus capitis, Medical microbiology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Drug Resistance, Multiple, Bacterial, Medicine, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, biology, Brief Report, Gestational age, General Medicine, Staphylococcal Infections, Anti-Bacterial Agents, 3. Good health, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Nationwide active surveillance, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Vancomycin, Female, France, 0305 other medical science, Infant, Premature, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, medicine.drug, Microbiology (medical), medicine.medical_specialty, Bloodstream catheter-related infection, Birth weight, Preterm babies, 030106 microbiology, Late onset, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Intensive Care Units, Neonatal, Sepsis, Intensive care, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, business.industry, Neonatal Intensive Care Unit (NICU), Infant, Newborn, Neonates, biology.organism_classification, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Catheter-Related Infections, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business
Abstract: To increase the knowledge about S. capitis in the neonatal setting, we conducted a nationwide 3-month survey in 38 neonatal intensive care units (NICUs) covering 56.6% of French NICU beds. We demonstrated 14.2% of S. capitis BSI (S.capBSI) among nosocomial BSIs. S.capBSI incidence rate was 0.59 per 1000 patient-days. A total of 55.0% of the S.capBSIs were late onset catheter-related BSIs. The S. capitis strains infected preterm babies (median gestational age 26 weeks, median birth weight 855 g). They were resistant to methicillin and aminoglycosides and belonged to the NRCS-A clone. Evolution was favorable in all but one case, following vancomycin treatment.
Published: 2020
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4. Sleep apnoea and endothelial dysfunction: An individual patient data meta-analysis

Author: Marie-Carmen Martinez, Ramaroson Andriantsitohaina, Wojciech Trzepizur, Vanessa Bironneau, François Goupil, Marie Joyeux-Faure, Jean-Louis Pépin, Mathieu Berger, Marc Le Vaillant, Sandrine Launois, Frédéric Gagnadoux, Ingrid Jullian-Desayes, Renaud Tamisier, Frédéric Roche, Stress Oxydant et Pathologies Métaboliques (SOPAM), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier du Mans, Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Recherche en Santé Respiratoire Pays de la Loire (IRSR PL), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Martinez, M. Carmen, Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Biologie, Ingénierie et Imagerie de la Greffe de Cornée (EA 2521, JE2521, IFR143), and Université Jean Monnet [Saint-Étienne] (UJM)
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV]Life Sciences [q-bio], Polysomnography, Blood Pressure, Hyperemia, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Severity of Illness Index, 03 medical and health sciences, Hyperaemia, 0302 clinical medicine, Sex Factors, Physiology (medical), Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Endothelial dysfunction, Hypoxia, ComputingMilieux_MISCELLANEOUS, Oxygen saturation (medicine), Sleep Apnea, Obstructive, medicine.diagnostic_test, business.industry, [SDV.BA]Life Sciences [q-bio]/Animal biology, Endothelial function, Patient data, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, medicine.disease, Sleep in non-human animals, 3. Good health, Peripheral, 030228 respiratory system, Neurology, Obstructive sleep apnoea, Meta-analysis, Cardiology, Reactive hyperaemia index, Neurology (clinical), Endothelium, Vascular, medicine.symptom, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery
Abstract: International audience; We performed an individual patient data meta-analysis to investigate the association between obstructive sleep apnoea (OSA) severity and the reactive hyperaemia index (RHI) measured by peripheral arterial tonometry (PAT), a validated measurement of endothelial function, and a strong predictor of late cardiovascular (CV) events. Patients from 12 studies underwent PAT and overnight polysomnography or respiratory polygraphy for suspected OSA. Endothelial dysfunction was defined by a log-transformed RHI20 min with oxygen saturation
Published: 2020
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5. Pre-participation cardiovascular evaluation in Pacific Island athletes

Author: Richard Donnadieu, Corinne Braunstein, François Carré, Frédéric Roche, Jean-Paul Grangeon, Satu Viali, Jean-Claude Barthélémy, Jean-Marie Sabot, François-Xavier Raby, Jean-Claude Chatard, Gérard Papouin, Karl Isaaz, Christian Guivarch, Régis Dacquin, Florian Espinosa, Antoine Gerbay, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Direction des affaires sanitaires et sociales de Nouvelle-Calédonie, Centre hospitalier territorial Gaston-Bourret [Nouméa], Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Laboratoire Traitement du Signal et de l'Image (LTSI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), This work was supported by a grant from Fond Pacific and the Ministère des Affaires Etrangères et du Développement international, AFD CTZ 1056 01 T and a grant from Philips industry., Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Cardiomyopathy, Physical examination, 030204 cardiovascular system & hematology, Pacific Islands, Sudden cardiac death, Pre-participation cardiovascular evaluation, Electrocardiography, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, T wave, medicine, Humans, Melanesians, 030212 general & internal medicine, Family history, Child, Exercise, Physical Examination, medicine.diagnostic_test, biology, Athletes, business.industry, Training level, medicine.disease, biology.organism_classification, T wave inversion, Death, Sudden, Cardiac, Cardiovascular Diseases, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Patient Participation, Abnormality, Polynesians, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract: International audience; Background - Pre-participation cardiovascular evaluation (PPE) aims to detect cardiac disease with sudden cardiac death (SCD) risk. No study has focused on Pacific Island athletes. Methods - A total of 2281 Pacific Island athletes were studied with (i) a questionnaire on family, personal history and symptoms, (ii) a physical examination and (iii) a 12-lead ECG. Results - 85% presented a normal history and examination. A positive family history was 1.4-1.9 fold higher in Melanesians, Polynesians and Métis than in Caucasians, while a positive personal history, abnormal symptoms and abnormal examination was 1.3 fold higher in Melanesians and Métis than in others. Neither gender nor training level had a bearing on these results. Melanesians had higher T wave inversions (TWIs) in V2-V4 leads but had no CV abnormalities. Lateral or infero-lateral TWIs were found in 6 male and in 5 highly trained athletes and cardiomyopathies were diagnosed in 3/6 athletes. Overall, 3.9% athletes were found to have a CV abnormality and 0.8% had a risk of SCD. Polynesians and males were more at risk than the others while the level of training made no difference. In athletes at risk of SCD, the main detected CV diseases were cardiomyopathies, Wolff-Parkinson-White (WPW) and severe valve lesions of rheumatoid origin. Conclusions - PPE revealed that 3.9% presented CV abnormalities. A risk of SCD was found in 0.8% with cardiomyopathies, WPW, and severe valve lesions of rheumatoid origin. Melanesians, Polynesians and male of high level of training were more at risk than others.
Published: 2019
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6. Improving methodology in heart rate variability analysis for the premature infants: Impact of the time length

Author: Nguyen Phuc Thu, Trang, Hernández, Alfredo I., Costet, Nathalie, Patural, Hugues, Pichot, Vincent, Carrault, Guy, Beuchée, Alain, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Réanimation pédiatrique et Néonatalogie [CHU Saint Etienne], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), This work is part of European DigiNewB Project and has received the funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 689260 (Digi-NewB project). Further information about this project can be found at http://www.diginewb.eu., European Project: 689260,H2020,H2020-PHC-2015-single-stage,Digi-NewB(2016), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Réanimation Néonatale [Saint-Étienne], Pôle Mère-Enfants [Saint-Étienne], Hôpital Nord [Saint-Étienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Hôpital Nord [Saint-Étienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Bodescot, Myriam, and Non-invasive monitoring of perinatal health through multiparametric digital representation of clinically relevant functions for improving clinical intervention in neonatal units (Digi-NewB) - Digi-NewB - - H20202016-03-01 - 2020-02-29 - 689260 - VALID
Subjects: Male, Time Factors, Entropy, Infographics, Database and Informatics Methods, Families, Electrocardiography, Mathematical and Statistical Techniques, Heart Rate, Medicine and Health Sciences, Cluster Analysis, Diagnosis, Computer-Assisted, Longitudinal Studies, Children, Principal Component Analysis, Physics, Statistics, Signal Processing, Computer-Assisted, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Physical Sciences, Thermodynamics, Medicine, Female, Sequence Analysis, Graphs, Infants, Infant, Premature, Research Article, Computer and Information Sciences, Bioinformatics, Science, Cardiology, Research and Analysis Methods, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Heart Rate Determination, Humans, Statistical Methods, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Data Visualization, Infant, Newborn, Biology and Life Sciences, Neonates, Infant, Nonlinear Dynamics, Age Groups, People and Places, Multivariate Analysis, Linear Models, Population Groupings, K Means Clustering, Mathematics, Developmental Biology
Abstract: BackgroundHeart rate variability (HRV) has been emerging in neonatal medicine. It may help for the early diagnosis of pathology and estimation of autonomous maturation. There is a lack of standardization and automation in the selection of the sequences to analyze and some features have not been explored in this specific population. The main objective of this study was to analyze the impact of the time length of the sequences on the estimation of linear and non-linear HRV features, including horizontal visibility graphs (HVG).MethodsHRV features were repeatedly measured with linear and non-linear methods on 2-, 5-, 10-minute sequences selected from the longest 15-min sequence and recorded on a weekly basis in 39 infants less than 31 weeks at birth. The associations between HRV measurements were analyzed through principal component analysis and k-means clustering. The effects of the time lengths on HRV measurements and post-menstrual age (PMA) were analyzed by linear mixed effect model for repeated measures.ResultsThe domains of analysis were concordant for their descriptive parameters of short (rMSSD, SD1 and HF) and long-term (SD, SD2 and LF) variability. α1 was correlated with the LF/HF and SD2/SD1. DC and AC were correlated with short-term variability estimates and significantly increased with GA and PMA. Shortening the windows of analysis increased the random measurement error for all the features and increased the bias for all but short term features and HVGs.ConclusionThe linear and non-linear measurements of HRV are correlated each other. Shortening the windows of analysis increased the random error for all the features and increased the bias for all but short term features and HVGs. Short-term HRV can be an index for evaluating the maturation in whatever sequence length.
Published: 2019
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7. Autonomic maturation from birth to 2 years: normative values

Author: Hugues Patural, Sophie Flori, Antoine Giraud, Patricia Franco, Frédéric Roche, Alain Beuchée, Vincent Pichot, Patrick Pladys, Jean-Claude Barthélémy, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), French Ministry of Health, Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Jonchère, Laurent, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)
Subjects: 0301 basic medicine, medicine.medical_specialty, Percentile, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Heart rate, medicine, Heart rate variability, lcsh:Social sciences (General), lcsh:Science (General), [SDV.IB] Life Sciences [q-bio]/Bioengineering, Multidisciplinary, business.industry, Healthy population, Gestational age, Autonomic nervous system, 030104 developmental biology, Cohort, Cardiology, Normative, [SDV.IB]Life Sciences [q-bio]/Bioengineering, lcsh:H1-99, business, 030217 neurology & neurosurgery, lcsh:Q1-390, Neuroscience
Abstract: International audience; Background While heart rate variability (HRV) constitutes a relevant non-invasive tool to assess the autonomic nervous system (ANS) function with recognized diagnostic or therapeutic implications, there is still a lack of established data on maturation of autonomic control of heart rate during the first months of life. The Autonomic Baby Evaluation (AuBE) cohort was built to establish, the normal autonomic maturation profile from birth up to 2 years, in a healthy population of full-term newborns. Methods Heart rate variability analysis was carried out in 271 full-term newborns (mean gestational age 39 wGA + 5 days) from reliable polysomnographic recordings at 0 (n = 270) and 6 (n = 221) months and from a 24-hour ambulatory electrocardiogram (ECG) at 12 (n = 210), 18 (n = 197), and 24 (n = 190) months. Indices of HRV analysis were calculated through the ANSLabTools software. Results Indices are dissociated according a temporal, geometrical, frequency, Poincaré empirical mode decomposition, fractal, Chaos and DC/AC and entropy analysis. Each index is presented for five different periods of time, 0, 6, 12, 18 and 24 months and with smoothed values in the 3rd, 10th, 50th, 90th and 97th percentiles. Data are also presented for the full cohort and individualized by sex to account for gender variability. Discussion and conclusion The physiological autonomic maturation profile from birth to 2 years in a healthy population of term neonates results in a fine-tuning autonomic maturation underlying progressively a new equilibrium and privileging the parasympathetic activity over the sympathetic activity. © 2019 The Authors
Published: 2018
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8. Post-exercise ankle blood pressure and ankle to brachial index after heavy load bicycle exercise

Author: T. Le Tourneau, J. F. Hamel, David Hupin, François Vincent, François Carré, Antoine Bruneau, Pierre Abraham, Raphael Godet, Samir Henni, Bruno Vielle, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire Traitement du Signal et de l'Image (LTSI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Hôpital Pontchaillou, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), SORMES, Mairie d'Angers, Unité de recherche de l'institut du thorax (ITX-lab), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Population, Physical Therapy, Sports Therapy and Rehabilitation, Blood Pressure, 030204 cardiovascular system & hematology, Asymptomatic, Incremental exercise, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Post exercise, medicine, Humans, Orthopedics and Sports Medicine, Prospective Studies, education, Prospective cohort study, Aged, education.field_of_study, business.industry, 030229 sport sciences, Middle Aged, Bicycling, ankle brachial index, medicine.anatomical_structure, Blood pressure, Cardiology, Exercise Test, Female, Analysis of variance, Ankle, medicine.symptom, business
Abstract: International audience; The American Heart Association (AHA) recommendations for diagnosing peripheral artery disease (PAD) after exercise are a decrease >20% of ankle brachial index (ABI) or >30 mm Hg of ankle systolic blood pressure (ASBP) from resting values. We evaluated ABI and ASBP values during incremental maximal exercise in physically active and asymptomatic patients. Patients (n = 726) underwent incremental bicycle tests with pre- and post-exercise recording of all four limbs arterial pressures simultaneously. Univariate and multivariate analyses were performed to define the correlation between post-exercise ABI with various clinical factors, including age. Thereafter, the population was divided into groups of age: less than 40 (G
Published: 2018
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9. Ankle pressure and ankle brachial index after heavy load incremental exercise

Author: Bruno Vielle, Samir Henni, J. F. Hamel, Raphael Godet, David Hupin, François Vincent, François Carré, Antoine Bruneau, Thierry Le Tourneau, Pierre Abraham, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire Traitement du Signal et de l'Image (LTSI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Hôpital Pontchaillou, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche de l'institut du thorax (ITX-lab), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_specialty, Index (economics), Brachial Artery, [SDV]Life Sciences [q-bio], Heavy load, Physical Therapy, Sports Therapy and Rehabilitation, Blood Pressure, 030204 cardiovascular system & hematology, Incremental exercise, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, Medicine, Orthopedics and Sports Medicine, Brachial artery, Exercise, ComputingMilieux_MISCELLANEOUS, business.industry, 030229 sport sciences, ankle brachial index, Blood pressure, medicine.anatomical_structure, Cardiology, Ankle, business, Ankle Joint
Abstract: International audience
Published: 2018
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10. Poids et Effets du genre dans l'aide aux seniors. Rapport intermédiaire

Author: Maks Banens, Nathalie Barth, Cécile Boukabza, Nathalie Le Roux, Anne Marcellini, Julie Thomas, Centre Max Weber (CMW), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Université Lumière - Lyon 2 (UL2), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Ministère de l'Education Nationale, Santé, Education et Situations de Handicap (SantESiH), Université de Montpellier (UM), Université de Lausanne (UNIL), centre de recherche sur les parcours de vie et les inégalités, Université Jean Monnet [Saint-Étienne] (UJM), Université de Lyon, DREES-Mire, PEGASE, École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Ministère de l'Éducation nationale, Université de Lausanne = University of Lausanne (UNIL), and Université Jean Monnet - Saint-Étienne (UJM)
Subjects: [SHS.SOCIO]Humanities and Social Sciences/Sociology, genre, Aide familiale aux personnes âgées, Dépendance des personnes âgées, aide filiale aux personnes âgées, santé, aide conjugale
Published: 2017

11. Poids et Effets du genre dans l'aide aux seniors. Note méthodologique

Author: Maks Banens, Nathalie Barth, Cécile Boukabza, Nathalie Le Roux, Anne Marcellini, Julie Thomas, Centre Max Weber (CMW), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Université Lumière - Lyon 2 (UL2), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Ministère de l'Éducation nationale, Santé, Education et Situations de Handicap (SantESiH), Université de Montpellier (UM), Université de Lausanne = University of Lausanne (UNIL), centre de recherche sur les parcours de vie et les inégalités, Université Jean Monnet - Saint-Étienne (UJM), Université de Lyon, DREES-Mire, PEGASE, École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Ministère de l'Education Nationale, Université de Lausanne (UNIL), and Université Jean Monnet [Saint-Étienne] (UJM)
Subjects: [SHS.SOCIO]Humanities and Social Sciences/Sociology, genre, Aide familiale aux personnes âgées, Dépendance des personnes âgées, aide filiale aux personnes âgées, santé, aide conjugale
Published: 2017

12. Altered sleep architecture during the first months of life in infants born to depressed mothers

Author: Véronique Porcher-Guinet, Patricia Franco, Aurore Guyon, Gianluca Sesso, F. Bat-Pitault, Sabine Plancoulaine, Christine Deruelle, Joëlle Adrien, Hugues Patural, D. Da Fonseca, Sophie Flori, Camille Stagnara, Institut de Neurosciences de la Timone (INT), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Physiologie integrée du système d'éveil, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-IFR19-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Pédopsychiatrie, Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon], Hospices Civils de Lyon (HCL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Génétique Humaine des Maladies Infectieuses (Inserm U980), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Sleep Wake Disorders, Pediatrics, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Mothers, Polysomnography, Non-rapid eye movement sleep, Arousal, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Risk Factors, medicine, Humans, Depression (differential diagnoses), ComputingMilieux_MISCELLANEOUS, Depressive Disorder, Major, medicine.diagnostic_test, Infant, Newborn, Infant, Eye movement, General Medicine, Sleep architecture, Sleep time, Sleep in non-human animals, 030227 psychiatry, Prenatal Exposure Delayed Effects, Female, Sleep, Psychology, 030217 neurology & neurosurgery
Abstract: Objective This study investigated sleep architecture in newborn and six-month-old infants who were born to depressed mothers. Method Sixty-four healthy full-term infants (32 males and 32 females) participated in the study. Of these, 32 were high-risk infants who were born to mothers diagnosed with depression, and 32 were low-risk infants born to mothers without a personal history of depression. 24-hour polysomnography was recorded at zero and six months of age (M0 and M6). Sleep macro-structural parameters (total sleep time, TST; awake time; non-rapid eye movement, NREM sleep (%); rapid eye movement, REM sleep %; arousal index; and sleep efficiency) were analysed at M0 and M6. Micro-architectural sleep features (slow-wave activity, SWA; delta sleep ratio, DSR; spindle density; and rapid eye movement density) were calculated at M6. The data between high-risk and low-risk groups were compared using Student's t -tests. Results At M0 and M6, the high-risk infants showed more awake time and fewer arousals than the low-risk infants. However, the high-risk group had less NREM% at M0 and a shorter TST as well as less REM% at M6 than the low-risk group. At M6, the high-risk group showed higher SWA, higher DSR and lower spindle density in comparison with the low-risk group. Conclusions Altered sleep structure was observed during their first months of life in infants born from depressed mothers, thereby suggesting that the prenatal environment could enhance the depression vulnerability of the child and potentially decrease their neuroplasticity.
Published: 2017
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13. Sleep Trajectories Among Pregnant Women and the Impact on Outcomes: A Population-Based Cohort Study

Author: F. Bat-Pitault, Sabine Plancoulaine, Sophie Flori, Hugues Patural, Jian-Sheng Lin, Patricia Franco, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)
Subjects: Adult, medicine.medical_specialty, Longitudinal study, Adolescent, Epidemiology, Longitudinal study Sleep, Population, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Developmental psychology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Surveys and Questionnaires, Infant Mortality, Outcome Assessment, Health Care, medicine, Humans, 030212 general & internal medicine, Restless legs syndrome, Longitudinal Studies, education, Depression (differential diagnoses), education.field_of_study, Pregnancy outcomes, Public health, Obstetrics, business.industry, Public Health, Environmental and Occupational Health, Obstetrics and Gynecology, Gestational age, Infant, medicine.disease, Pediatrics, Perinatology and Child Health, Cohort, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Pregnant Women, business, Sleep, 030217 neurology & neurosurgery
Abstract: International audience; Objectives Sleep problems and deprivation are common during pregnancy, particularly in the third trimester. Previous studies are mostly descriptive or focused on specific clinical groups and late pregnancy. We aimed to identify sleep duration trajectories during the pregnancy period, their associated factors, and impact on pregnancy and birth outcomes.Methods We studied 200 women from a mother–child cohort recruited in 2009–2011 from the French general population. We used semi-parametric models to analyze data collected through questionnaires.Results: We detected three sleep duration trajectories during pregnancy: short-decreasing (8h/night, 31.6%) trajectories. Factors associated with the short-decreasing trajectory relative to the medium-decreasing trajectory were older age (odds-ratio/year = 1.13 [95%Confidence-Interval 1.00-1.29]) and working > 28 weeks of gestational age (odds-ratio = 0.30 [0.10–0.90]). Sleep duration during pregnancy in this trajectory group was modified by insomniac symptoms (regression coefficient/trimester = −0.74 [Standard-Error 0.12]) and naps (regression coefficient/trimester = 0.58 [0.25]). Restless legs syndrome was the only factor associated with the long-increasing trajectory and decreased sleep duration (regression coefficient/trimester = −0.88 [0.25]). Assisted delivery (i.e. cesarean section and/or instrumental delivery) and post-partum depression were more frequent among women with the short-decreasing and long-increasing trajectories whereas cesarean section alone was more prevalent among those with the short-decreasing trajectory. Proportion of premature births was higher in the short-decreasing trajectory group. Birth-weight-z-score was lower in the long-increasing trajectory group.Conclusion: We identified sleep trajectories among pregnant women with specific risk factors that could affect both pregnancy and birth outcomes. Taking these into consideration could improve both maternal and child health.
Published: 2017
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14. We need clear health messages about exercise

Author: Jean-Claude Barthélémy, Frédéric Roche, David Hupin, Pascal Edouard, Vincent Gremaux, Laboratoire Interuniversitaire de Biologie de la Motricité ( LIBM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé ( SNA-EPIS ), Université Jean Monnet [Saint-Étienne] ( UJM ) -Centre Hospitalier Universitaire de Saint-Etienne, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] ( PIT ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie ( CIC-P803 ), Université de Bourgogne ( UB ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme d’Investigation Technologique [Centre d’Investigation Clinique 1432 module Plurithématique - Dijon] (PIT), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre d'Investigation Clinique 1432 (Dijon) - Module Plurithématique : Périnatalité Cancérologie Handicap et Ophtalmologie (CIC-P803), and Université de Bourgogne (UB)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_specialty, Medical education, Consumer Health Information, business.industry, Physical activity, Alternative medicine, Headline, 030229 sport sciences, General Medicine, Health Promotion, Sitting, World Health Organization, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine, Humans, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030212 general & internal medicine, Mass Media, business, Exercise, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Simplifying health messages can be puzzling. French media recently criticised WHO’s 2016 physical activity recommendations, based on the data published by Kyu and colleagues in The BMJ. Two years ago, they ran a very different headline: “Sitting kills more people than tobacco,” based on a commentary published in 2009.
Published: 2016
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15. Methods and Barriers to the Prescription of Physical Activity to Patients with Chronic Illness: The Viewpoint of General Practitioners

Author: Tchirkov, Vitaly, Didierjean, Romaine, Schuft, Laura, Thomas, Julie, Hupin, David, Laboratoire d'Études et de Recherche en Sociologie (LABERS), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), Laboratoire Activités Physiques et Sportives et processus PSYchologiques : recherches sur les Vulnérabilités (APSY-V), Université de Nîmes (UNIMES), Unite de recherche migrations et sociétés (URMIS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de recherche pour le développement [IRD] : UR205-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Côte d'Azur (UCA), Centre Max Weber (CMW), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Université Jean Monnet - Saint-Étienne (UJM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), MSH-LSE, Fondation UJM, and IRESP/CNSA
Subjects: [SHS.SOCIO]Humanities and Social Sciences/Sociology, systematic review, General practitioners, Prescription of physical activity, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Long-term illness, Chronic illness
Abstract: International audience; Introduction: As a result of recent legislation designed to modernize the healthcare system (2016 French Healthcare Act and its Implementing Decree), General Practitioners (GP) in France can now prescribe Adapted Physical Activity (APA) to patients with a long-term illness.Purpose of Research: To understand and explain the obstacles that physicians and their patients still encounter, thereby hindering the accessibility and effectiveness of APA, we carried out a meta-analysis of 22 French medical theses defended between 2016 and 2020.Results: Despite the new legislation, very few general GP prescribed APA during the period we studied. Lack of time during consultations, lack of relevant training, lack of knowledge about where to send patients for APA, and mistrust of APA providers appeared to be the main obstacles to prescribing APA as a non-drug therapy. The GP's own lifestyle, the nature of the GP patient relationship, and the GP's perception of the patient's attitude to sport also seemed to influence the decision to prescribe APA.Conclusion: Scant attention has been paid to GP' viewpoint, either in the scientific literature or in recent policies regarding the implementation of APA prescribing in France. This meta-analysis points to a need for more research and for public policies that consider the perspectives of these prescribing physicians and their relationships with their patients.
Published: 2023
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16. Personality, Alzheimer's disease and behavioural and cognitive symptoms of dementia: the PACO prospective cohort study protocol

Author: Jean-Michel Dorey, Pierre Krolak-Salmon, Catherine Padovan, Florence Dibie-Racoupeau, Marie-Anne Hénaff, Denis Federico, Bernard Laurent, Michel Benoit, Marie-Odile Barrellon, Nawele Boublay, Zaza Makaroff, Isabelle Rouch, Sandrine Harston, Dupuis, Christine, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Unité de Gériatrie, Hôpital des Charpennes [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Centre Mémoire de Ressources et de Recherche (CMRR Lyon), Unité de Neurologie, CHU Saint-Etienne-Centre Mémoire de Ressources et de Recherche (CMRR Saint-Etienne), Psychiatrie, Centre Hospitalier le Vinatier [Bron], Pôle Information Médicale Evaluation Recherche (IMER), Hospices Civils de Lyon (HCL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pôle de Gérontopsychiatrie, Hôpital Saint Jean de Dieu, Hôpital Xavier Arnozan - CHU de Bordeaux, Unité de Psychiatrie, Hôpital Pasteur [Nice] (CHU), Médecine Gériatrie, Centre hospitalier L'Hôpital du Gier (Saint-Chamond), The PACO study has been funded by the National French Program ofHospital Clinical Research (Programme Hospitalier de Recherche CliniqueNational 2009 and 2010), France Alzheimer, Janssen laboratory grants., The PACO Group : MO Barrellon, M Benoit, B Laurent, Z Makaroff, F Blanc, H Mollion, O Moreaud, C Padovan, X de Pétigny, P Rebaudet, S Relland, P H Robert, JM Dorey, I Roullet Solignac, O Rouaud, I Rouch, M Bonnefoy, F Sellal, C Terrat and A Vighetto., N Boublay, S Brengarth, MH Coste, B Croisile, D Federico, M Debray, F Dibie-Racoupeau, I Gallice, S Gaujard, P Grosmaitre, S Harston, MA Hénaff, P Krolak-Salmon, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé ( SNA-EPIS ), Université Jean Monnet [Saint-Étienne] ( UJM ) -Centre Hospitalier Universitaire de Saint-Etienne, Centre Mémoire de Ressources et de Recherche ( CMRR Lyon ) -Hôpital des Charpennes [CHU - HCL], Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), CHU Saint-Etienne-Centre Mémoire de Ressources et de Recherche ( CMRR Saint-Etienne ), Pôle Information Médicale Evaluation Recherche ( IMER ), Hospices Civils de Lyon ( HCL ), Centre de recherche en neurosciences de Lyon ( CRNL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Hôpital Pasteur [Nice] ( CHU ), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre de recherche en neurosciences de Lyon (CRNL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, medicine.medical_specialty, Personality Inventory, media_common.quotation_subject, Population, [ SDV.MHEP.GEG ] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Neuropsychological Tests, Study Protocol, Cognition, Social cognition, Alzheimer Disease, medicine, Dementia, Personality, Humans, Behaviour, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Prospective Studies, 10. No inequality, Psychiatry, education, media_common, Aged, education.field_of_study, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, business.industry, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Retrospective cohort study, Middle Aged, medicine.disease, Magnetic Resonance Imaging, 3. Good health, Caregivers, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Disease Progression, Quality of Life, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Geriatrics and Gerontology, Personality Assessment Inventory, Alzheimer's disease, business, Alzheimer’s disease, Cohort study, Follow-Up Studies
Abstract: Alzheimer’s disease is characterised by a loss of cognitive function and behavioural problems as set out in the term “Behavioural and Psychological Symptoms of Dementia”. These behavioural symptoms have heavy consequences for the patients and their families. A greater understanding of behavioural symptoms risk factors would allow better detection of those patients, a better understanding of crisis situations and better management of these patients. Some retrospective studies or simple observations suggested that personality could play a role in the occurrence of behavioural symptoms. Finally, performance in social cognition like facial recognition and perspective taking could be linked to certain personality traits and the subsequent risks of behavioural symptoms. We propose to clarify this through a prospective, multicentre, multidisciplinary study. Main Objective: - To assess the effect of personality and life events on the risk of developing behavioural symptoms. Secondary Objectives: - To evaluate, at the time of inclusion, the connection between personality and performance in social cognition tests; - To evaluate the correlation between performance in social cognition at inclusion and the risks of occurrence of behavioural symptoms; - To evaluate the correlation between regional cerebral atrophy, using brain Magnetic Resonance Imaging at baseline, and the risk of behavioural symptoms. Study type and Population: Prospective multicentre cohort study with 252 patients with Alzheimer’s disease at prodromal or mild dementia stage. The inclusion period will be of 18 months and the patients will be followed during 18 months. The initial evaluation will include: a clinical and neuropsychological examination, collection of behavioural symptoms data (Neuropsychiatric-Inventory scale) and their risk factors, a personality study using both a dimensional (personality traits) and categorical approach, an inventory of life events, social cognition tests and an Magnetic Resonance Imaging. Patients will be followed every 6 months (clinical examination and collection of behavioural symptoms data and risk factors) during 18 months. This study aims at better identifying the patients with Alzheimer’s disease at high risk of developing behavioural symptoms, to anticipate, detect and quickly treat these disorders and so, prevent serious consequences for the patient and his caregivers. ClincalTrials.gov: NCT01297140
Published: 2014
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17. Results from the French National Esophageal Atresia register: one-year outcome

Author: Frédéric Gottrand, J.-L. Lemelle, Laurent Michaud, Rony Sfeir, Josephine Borgnon, J. Gaudin, Cécile Pelatan, Virginie Fouquet, Frédéric Auber, Christophe Laplace, J. Languepin, Frederic Lavrand, Jean-Luc Michel, Hubert Lardy, Thierry Petit, Guillaume Podevin, Allal Hossein, Anne Breton, P. Buisson, M.L. Poli-Merol, Arnaud Bonnard, Pascal de Lagausie, Corine Borderon, Olivier Jaby, Dominique Weil, Anis Echaieb, Manuel Lopez, Anne Schneider, F Elbaz, Myriam Pouzac, Thierry Merrot, François Becmeur, Jean Breaud, S. Geiss, François Lefebvre, Sébastien Blanc, Naziha Khen-Dunlop, Didier Aubert, Catherine Jacquier, E. Habonimana, Philine De Vries, Terres Inovia, PremUp Foundation, Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Chirurgie Viscérale Pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Diabétologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Hôpital Jeanne de Flandre [Lille], Inflammation: mécanismes et régulation et interactions avec la nutrition et les candidoses, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Hôpital Bicètre, Service de chirurgie pédiatrique, Hôpital Bicêtre, service de chirurgie viscérale pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de chirurgie pédiatrique [CHU Bordeaux], Hôpital des Enfants - Groupe hospitalier Pellegrin - CHU de Bordeaux, Service de chirurgie pédiatrique [CHU Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Mines Nantes (Mines Nantes), Theory, Algorithms and Systems for Constraints (TASC), Laboratoire d'Informatique de Nantes Atlantique (LINA), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Département informatique - EMN, Mines Nantes (Mines Nantes)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Service de Pédiatrie, Centre Hospitalier Universitaire de Reims (CHU Reims)-American Memorial Hospital (Reims), Université de Reims Champagne-Ardenne (URCA), UMR 6578 : Anthropologie Bio-Culturelle (UAABC), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie et Radiologie Pédiatrique, Université de la Méditerranée - Aix-Marseille 2, Laboratoire de recherche sur la gouvernance publique, territoire et communication (LARGOTEC/CECCOPOP), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA - EPIS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), CHU Pontchaillou [Rennes], Centre Hospitalier Le Mans (CH Le Mans), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Régional Universitaire de Tours (CHRU de Tours), Service Pédiatrie, Centre Hospitalier Universitaire [Rennes], Service de chirurgie pédiatrique [CHU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire de Nice (CHU Nice), Service de Chirurgie infantile, CHU Fort de France-Hôpital Pierre Zobda Quitman, CHU Clermont-Ferrand, CHU Strasbourg, Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Union Nationale Interprofessionnelle des plantes riches en Protéines (UNIP), Service de chirurgie viscérale pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Gastro-entérologie, Hépatologie, Nutrition, Diabétologie, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Institut de Recherche pour le Développement (IRD)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-CHI Créteil-Université Paris Descartes - Paris 5 (UPD5)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital des Enfants, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Université de Lille, Droit et Santé-Institut National de la Santé et de la Recherche Médicale (INSERM), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Département informatique - EMN, Mines Nantes (Mines Nantes)-Mines Nantes (Mines Nantes)-Laboratoire d'Informatique de Nantes Atlantique (LINA), and Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Time Factors, Long term follow up, One-year outcome, [SDV]Life Sciences [q-bio], Pharmacology toxicology, Population, Treatment outcome, Outcome (game theory), Population-based registry, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, medicine, Humans, Genetics(clinical), Pharmacology (medical), Registries, 030212 general & internal medicine, education, Esophageal Atresia, Long-term follow-up, Genetics (clinical), Medicine(all), 2. Zero hunger, education.field_of_study, business.industry, Research, Infant, Newborn, Infant, General Medicine, medicine.disease, 3. Good health, Hospitalization, Treatment Outcome, Register (music), Population Surveillance, Atresia, Female, France, business, Population-Based Registry, Follow-Up Studies
Abstract: Background The aim of the present national prospective population-based study was to assess the early morbidity of esophageal atresia (EA). Methods All 38 multidisciplinary French centers that care for patients with EA returned a specific questionnaire about the 1-year outcome for each patient. This information was centralized, checked, and entered into a database. Results From the total population of 307 EA patients born in 2008 and 2009, data about the 1-year outcome were obtained from 301 (98%) patients, of whom 4% were lost to follow-up and 5% died. Medical complications occurred in 34% of the patients: anastomotic leaks (8%), recurrent tracheoesophageal fistula (4%), and anastomotic stenosis (22%); all of the latter group needed dilation (median, 2 dilations/patient). A new hospitalization was required for 59% of patients (2.5 hospitalizations/patient) for digestive (52%) or respiratory (48%) reasons. Twelve percent of patients required antireflux surgery at a median age of 164 days (range, 33–398 days), and 1% underwent an aortopexy for severe tracheomalacia. The weight/age Z-score was −0.8 (range, −5.5 to 3.7 months) at 12 months. Fifteen percent of patients were undernourished at 12 months of age, whereas 37% presented with respiratory symptoms and 15% had dysphagia at the last follow-up. Significant independent factors associated with medical complications were anastomotic esophageal tension (p = .0009) and presence of a gastrostomy (p = .0002); exclusive oral feeding at discharge was associated with a decreased risk of complications (p = .007). Conclusions Digestive and respiratory morbidities remain frequent during the first year of life and are associated with difficult anastomosis and lack of full oral feeding. Electronic supplementary material The online version of this article (doi:10.1186/s13023-014-0206-5) contains supplementary material, which is available to authorized users.
Published: 2014
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18. What do women and healthcare professionals expect of decision aids for breast cancer screening? A qualitative study in France

Author: Aïm-Eusébi Amélie, Yannick Ruelle, Bernard Frèche, Mélanie Houllemare, Aurélie Bonillo, Laurie Bouaziz, Cédric Rat, Xavier Gocko, Catherine Cerisey, Isabelle Aubin-Auger, Emilie Ferrat, Ruelle, Yannick, Université Paris Cité (UPCité), Laboratoire éducations et promotion de la santé (LEPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Nord, Collège National des Généralistes Enseignants (CNGE), Département universitaire de médecine générale, Université Sorbonne Paris Nord (DUMG USPN), Centres municipaux de santé universitaires de Pantin (CMSU Pantin), Université de Poitiers, Université Sorbonne Paris Nord, Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers (CRCI2NA ), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, IMRB - CEPIA/'Clinical Epidemiology And Ageing : Geriatrics, Primary Care and Public Health' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), and Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)
Subjects: Decision Making, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, breast tumours, General Medicine, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, preventive medicine, Decision Support Techniques, primary care, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, France, Delivery of Health Care, Early Detection of Cancer, Qualitative Research
Abstract: ObjectiveBreast cancer screening decision aids (DAs) are designed to help women decide whether or not to participate in mammography-based programmes. We aimed to explore women’s and healthcare professionals’ expectations of a breast cancer screening DA, as part of the French DEDICACES study.MethodsThis French qualitative study was based on semistructured, individual interviews with women from the general population, general practitioners (GPs), midwives, gynaecologists, radiologists and screening centre managers. Sampling was purposive and used diversification criteria. The inductive analysis was based on grounded theory.ResultsBetween April 2018 and May 2019, we interviewed 40 people: 13 women, 14 GPs, 4 gynaecologists, 3 midwives, 3 radiologists and 3 screening centre managers. The women and the healthcare professionals considered that a DA could help to improve levels of knowledge, harmonise medical practice and provide reliable, comprehensive information. Overall, the interviewees wanted an easy-to-use, intuitive, graphic-rich, interactive, computer-based, patient-centred DA. Use of the DA might be limited by a lack of familiarity with shared decision-making (SDM), the risk of misuse and a preference for asymmetric positive information.ConclusionThe present results are likely to facilitate the development of the first validated tool for SDM support in French breast cancer screening programmes.
Published: 2022
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19. Prevention of Atrial Fibrillation After Atrial Flutter Ablation With Ramipril (from the PREFACE Study)

Author: Jacques Mansourati, Yannick Saludas, Céline Chapelle, Jean-Luc Pasquié, Silvy Laporte, Karl Isaaz, Antoine Da Costa, Arnauld Garcin, Dominique Pavin, Jean-Baptiste Guichard, Jean-Claude Barthélémy, Frédéric Roche, Pascal Defaye, Frédéric Anselme, Cécile Romeyer, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), CHU Rouen, Normandie Université (NU), Centre Hospitalier Universitaire [Grenoble] (CHU), Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Clermont-Ferrand, Biologie intégrative du tissu osseux, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and MORNET, Dominique
Subjects: Ramipril, Male, medicine.medical_specialty, Heart disease, Radiofrequency ablation, [SDV]Life Sciences [q-bio], Population, Angiotensin-Converting Enzyme Inhibitors, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, law, Recurrence, Internal medicine, Atrial Fibrillation, Medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Prospective Studies, education, Stroke, Aged, education.field_of_study, business.industry, Atrial fibrillation, Middle Aged, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Hospitalization, Treatment Outcome, Atrial Flutter, Heart failure, Cardiology, Catheter Ablation, Electrocardiography, Ambulatory, Female, Cardiology and Cardiovascular Medicine, business, Atrial flutter, medicine.drug, Follow-Up Studies
Abstract: International audience; The clinical efficacy of the inhibitors of the renin-angiotensin-aldosterone system (RAAS) as an upstream therapy for atrial fibrillation (AF) prevention is controversial. No study has itemized so far the role of RAAS inhibitors in AF prevention after atrial flutter (AFL) ablation. This trial aims to investigate the effect of ramipril compared with placebo on AF occurrence in patients hospitalized for AFL ablation without structural heart disease. The Prevention of Atrial Fibrillation by Inhibition Conversion Enzyme (ICE) After Radiofrequency Ablation of Atrial Flutter (PREFACE) trial was a prospective, multicenter, randomized, double-blind, double-dummy trial depicting the AF occurrence during a 12-month follow-up as the primary end point. A total of 198 patients hospitalized for AFL ablation were enrolled in the trial and randomized to placebo or ramipril 5 mg/day. Patients were followed up during 1 year after AFL ablation using 1-week Holter electrocardiogram at 3, 6, 9, and 12 months. The intention-to-treat population encompassed 97 patients in the ramipril group and 101 patients in the placebo group. The primary end point, such as AF occurrence during the 1-year follow-up, was not different between the 2 groups (p = 0.96). Secondary end points, including the occurrence of supraventricular arrhythmia (p = 0.50), heart failure, stroke, and death, were not different between the 2 groups. Safety outcome parameters, including serious adverse events leading to treatment disruption (p = 0.10), hypotension, impairment of renal function, and elevated serum potassium level, also were not different between the 2 groups. In conclusion, RAAS inhibition using ramipril does not reduce AF occurrence in patients facing AFL ablation during the 1-year follow-up.
Published: 2021
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20. Optimization of an Antisolvent Method for RDX Recrystallization: Influence on Particle Size and Internal Defects

Author: Gérard Coquerel, James Cooper, Denis Spitzer, Lionel Borne, Vincent Pichot, Mazheva Guillevic, Nanomatériaux pour les Systèmes Sous Sollicitations Extrêmes (NS3E), Université de Strasbourg (UNISTRA)-ISL-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, School of Electrical and Computer Engineering - Georgia Insitute of Technology (ECE GeorgiaTech), Georgia Institute of Technology [Atlanta], Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Institut franco-allemand de recherches de Saint-Louis (ISL), DGA-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Propre, and ISL-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)
Subjects: Recrystallization (geology), Materials science, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 02 engineering and technology, General Chemistry, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, Characterization (materials science), [SPI.MAT]Engineering Sciences [physics]/Materials, Chemical engineering, [CHIM.CRIS]Chemical Sciences/Cristallography, General Materials Science, Particle size, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: The present study deals with the synthesis and characterization of pure RDX as well as ND-RDX (nanodiamond–hexahydro-1,3,5-trinitro-1,3,5-triazine) core–shell composites. RDX is one of the most wid...
Published: 2020
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21. Récits de vie de patients greffés rénaux : de l’entrée dans la maladie à la greffe

Author: Plotton Catherine, Gocko Xavier, Vassal Pascale, Naro Mathilde, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon
Subjects: 03 medical and health sciences, 0302 clinical medicine, Nephrology, [SDV]Life Sciences [q-bio], 030232 urology & nephrology
Abstract: Resume Introduction En 2018, 14 291 patients attendaient une greffe renale et 3546 ont ete greffes. La loi du 26 janvier 2016 va dans le sens du consentement presume. Les sondages montrent une appetence des Francais pour plus d’informations. L’objectif de ce travail etait de decrire l’histoire de vie de patients greffes renaux pour repondre a ce besoin d’information. Methode Il s’agit d’une etude qualitative de type recit de vie, realisee en Auvergne-Rhone-Alpes, entre decembre 2016 et fevrier 2019. Les entretiens ont ete retranscrits integralement et analyses par deux chercheurs. L’echantillon a ete raisonne sur le genre, l’âge, le temps de dialyse et la categorie socio-professionnelle. La declaration a la Commission nationale informatique et libertes a ete realisee. Resultats La suffisance des donnees a ete atteinte au neuvieme entretien. L’entree dans la maladie pouvait etre insidieuse ou brutale. L’ensemble des patients interroges a modifie ses habitudes de vie. La dialyse permettait parfois de recuperer un peu d’autonomie, mais elle avait ses contraintes dietetiques et organisationnelles. La greffe, lorsqu’elle n’etait pas compliquee, diminuait nettement le fardeau de la maladie et du traitement. La difficile et angoissante attente de greffe etait remplacee par l’image de l’epee de Damocles avec le questionnement de la duree de vie du greffon. Le fardeau de la dialyse etait remplace par la crainte des effets indesirables des immunosuppresseurs. Les patients dependaient du greffon et cette dependance resonnait avec un devoir moral envers le donneur, l’entourage ou la famille et soi-meme. Conclusion L’insuffisance renale se compose de phases d’alternance de dependance et d’autonomie.
Published: 2020
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22. Impact de l'inflammation périnatale sur le cerveau en développement : de la dimension neurodéveloppementale à l'échelle endothéliale

Author: Giraud, Antoine, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Université de Lyon, Hugues Patural, Guillaume Sébire, and STAR, ABES
Subjects: Neurodéveloppement, Barrière hémato-encéphalique, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Group B streptococcus, Neurodevelopment, Interleukine-1, Streptocoque de groupe B, Chorioamnionitis, Modèle murin, Blood brain barrier, Chorioamniotite, Infarctus cérébral artériel néonatal, Perinatal inflammation, Murine model, Neonatal arterial cerebral infarction, Inflammation périnatale, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Interleukin-1
Abstract: The perinatal period is critical in the development of the brain parenchyma. The impact of a pro-inflammatory stress during this period has been studied using epidemiological studies and preclinical experiments.Several aspects of the impact of perinatal inflammation on the developing brain have been studied, from neurodevelopmental outcomes to cerebral endothelium modifications. This thesis demonstrates that: (1) exposure to perinatal inflammation is independently associated with poorer social and motor abilities at 30 months of corrected age in premature infants without severe neonatal brain injury, (2) end-gestational treatment by ampicillin increases placental inflammation in our preclinical rat model of group B streptococcal (GBS) chorioamnionitis without maternal bacteremia, (3) perinatal inflammation is the only consistent independent risk factor of neonatal arterial ischemic stroke, (4) end-gestational inflammation leads to a diffuse decrease in the permeability of the fetal blood-brain barrier in our preclinical rat model of GBS chorioamnionitis.Exposure to perinatal inflammation can be considered as an early brain injury. This consideration paves the way to new perspectives of neuroprotection targeted on the interleukin-1 blockade and new perspectives of early evaluation., La période périnatale est une période critique du développement du parenchyme cérébral. L’impact d’un stress pro-inflammatoire durant cette période critique a été étudié à l’aide de travaux épidémiologiques et d’expérimentations précliniques.Différents aspects de l’impact de l’inflammation périnatale sur le cerveau en développement ont été abordés, de la dimension neurodéveloppementale à l’échelle endothéliale. Cette thèse met en évidence que : (1) l’exposition à une inflammation périnatale est indépendamment associée à une diminution des capacités motrices globales et des capacités de socialisation à 30 mois d’âge corrigé chez les enfants prématurés ne présentant pas de complication cérébrale néonatale sévère, (2) un traitement par ampicilline en fin de gestation majore l’inflammation placentaire dans notre modèle préclinique de chorioamniotite à streptocoque de groupe B (SGB) sans bactériémie associée, (3) l’inflammation périnatale est le seul facteur de risque indépendant consistant d’infarctus cérébral artériel néonatal, (4) une chorioamniotite à SGB entraîne une diminution diffuse de la perméabilité de la barrière hémato-encéphalique fœtale dans notre modèle préclinique murin.L’exposition à une inflammation périnatale peut être considérée comme une lésion cérébrale précoce. Cette considération ouvre la voie à de nouvelles perspectives de neuroprotection ciblées sur l’interleukine-1 et d’évaluation précoce.
Published: 2020

23. Perinatal inflammation is associated with social and motor impairments in preterm children without severe neonatal brain injury

Author: Céline Chapelle, Marie-Julie Allard, Magali Celle, Stéphane Chabrier, Robin Chaux, Guillaume Sébire, Antoine Giraud, Georges Teyssier, Hugues Patural, Frédéric Roche, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), McGill University = Université McGill [Montréal, Canada], INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Biologie intégrative du tissu osseux, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre Ingénierie et Santé (CIS-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and CCSD, Accord Elsevier
Subjects: Male, Pediatrics, medicine.medical_specialty, Multivariate analysis, [SDV]Life Sciences [q-bio], Motor Disorders, Inflammation, Development, Infections, Chorioamnionitis, Infant, Newborn, Diseases, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, 030225 pediatrics, medicine, Humans, Child, Revised Brunet-Lézine scale, business.industry, Infant, Newborn, Neuropsychology, Infant, Social Behavior Disorders, Gestational age, General Medicine, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Early-onset neonatal infection, Neonatal infection, Cross-Sectional Studies, Pediatrics, Perinatology and Child Health, Cohort, Necrotizing enterocolitis, Female, Neurology (clinical), medicine.symptom, business, Prematurity, Infant, Premature, 030217 neurology & neurosurgery
Abstract: International audience; Objective: To test the association between exposure to perinatal inflammation - i.e. clinical chorioamnionitis or early-onset neonatal infection - in preterm children without severe neonatal brain injury and neurodevelopmental outcome at 30 months of corrected age (CA).Design: Cross-sectional study from a French regional cohort of clinical follow-up (SEVE Network).Patients: One hundred sixty-four surviving neonates without severe brain injury - namely, grade III and IV cerebral hemorrhage and cystic periventricular leukomalacia - and without late-onset neonatal inflammation exposure - namely, late-onset neonatal infection and necrotizing enterocolitis -, born at less than 33 weeks of gestational age from November 2011 to June 2015 and enrolled in the SEVE Network.Main outcome measure: Global developmental quotient (DQ) score of the revised Brunet-Lézine scale and its four indices measured by the same neuropsychologist at 30 months of CA.Results: After multivariate analysis, exposure to perinatal inflammation was not found significantly associated with a modification of the global DQ score (coefficient -1.7, 95% CI -4.8 to 1.3; p = 0.26). Exposure to perinatal inflammation was associated with a decrease of the gross motor function DQ score (coefficient -6.0, 95% CI -9.9 to -2.1; p < 0.01) and a decrease of the sociability DQ score (coefficient -5.1, 95% CI -9.2 to -0.9; p = 0.02). Language and visuospatial coordination DQ scores were not affected by exposure to perinatal inflammation.Conclusion: Exposure to perinatal inflammation in preterm children without severe neonatal brain injury is independently associated with decreased motor and social abilities at 30 months of CA.
Published: 2020
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24. Social marketing interventions to promote physical activity among 60 years and older: a systematic review of the literature

Author: Karine Gallopel-Morvan, Nathalie Barth, Bienvenu Bongue, Michael S. Mulvey, David Hupin, Frédéric Roche, Luc Goethals, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), University of Ottawa [Ottawa], EA Management des Organisations de Santé (EA MOS), École des Hautes Études en Santé Publique [EHESP] (EHESP)-PRES Sorbonne Paris Cité, École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut du Management (IDM), and Centre technique d’appui et de formation des centres d’examens de santé (CeTAF)
Subjects: Gerontology, medicine.medical_specialty, Population, Psychological intervention, Poison control, Suicide prevention, 03 medical and health sciences, 0302 clinical medicine, 0502 economics and business, Medicine, 030212 general & internal medicine, education, Interventions, education.field_of_study, business.industry, Physical activity, Public health, 030503 health policy & services, lcsh:Public aspects of medicine, 05 social sciences, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Social marketing, Physical activity level, [SHS.SCIPO]Humanities and Social Sciences/Political science, 3. Good health, Systematic review, Social Marketing, Older adults, 050211 marketing, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, 0305 other medical science, Research Article
Abstract: Background Falls are a significant source of morbidity in people aged 65 and over, affecting one in three people in this age group. The scientific evidence indicates that physical activity is the most effective method for preventing falls among seniors. Although public health professionals often use social marketing to design and plan successful interventions, its use to promote physical activity and prevent falls among older people remains low. This article aims to provide a new systematic literature review of social marketing interventions promoting physical activity and targeting people aged 60 and over. Methods Following CRD’s guidance and PRISMA guidelines, we searched between January 2008 and July 2019 for relevant articles in five primary databases using predefined search and inclusion criteria. Two independent reviewers analysed the selected articles to identify evidence of the seven social marketing benchmark criteria, defined by experts in the field as the common elements that contribute to social marketing success. Results The final review included nine studies. Of the studies selected, three specifically targeted over 60-year-olds, whereas the others segmented the population into several age-based subcategories, including over 60-year-olds. Eight studies highlighted positive results for the participants with an increase in participation or an increase in physical activity level. None of the nine studies selected for this systematic review implemented the entire social marketing approach. Conclusion Few published interventions use the seven social marketing criteria. Further research is required to encourage uptake and inclusion in successful social marketing interventions to increase program effectiveness in this target population.
Published: 2020
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25. Hypokalemia is frequent and has prognostic implications in stable patients attending the emergency department

Author: Emmanuel Montassier, João Pedro Ferreira, Béatrice Trombert-Paviot, Patrick Rossignol, Tahar Chouihed, Laure Abensur Vuillaume, Nicolas Girerd, Nathalie Asseray, Matthieu Legrand, Jean-Marc Boivin, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Service des urgences, Centre Hospitalier Régional Metz-Thionville, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de maladies infectieuses et tropicales [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de santé publique et d'information médicale [CHU Saint-Etienne] (SSPIM), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Service des Urgences [CHU Nantes], Hôtel-Dieu de Nantes, Department of Anaesthesiology, Critical Care Medicine and Burn Unit [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Chirurgie Générale et Urgences [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), The National Medicine Academy approved the study design and provided funding. The French Society for Clinical Pharmacy (SFPC) approved the protocol, supported the enrolment and training of pharmacy students and provided funding. ML reports receiving lecture fees from Baxter and Fresenius, research support from Sphingotec, and consulting fees from Novartis., Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôtel-Dieu-Université de Nantes (UN), Bodescot, Myriam, and Chen, Xiongwen
Subjects: Male, Emergency Medical Services, Critical Care and Emergency Medicine, Hyperkalemia, Cross-sectional study, Physiology, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Myocardial Infarction, Blood Pressure, 030204 cardiovascular system & hematology, Cardiovascular Medicine, Biochemistry, Vascular Medicine, 0302 clinical medicine, Medical Conditions, Emergency medical services, Medicine and Health Sciences, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Diuretics, education.field_of_study, Emergency Service, Multidisciplinary, Drugs, Health Services, Middle Aged, Prognosis, Hypokalemia, 3. Good health, Hospitalization, Treatment Outcome, Cardiovascular Diseases, Hypertension, Medicine, Female, medicine.symptom, Emergency Service, Hospital, medicine.drug, Research Article, Glomerular Filtration Rate, medicine.medical_specialty, General Science & Technology, Science, Population, Cardiology, 03 medical and health sciences, Hospital, Clinical Research, Internal medicine, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Hemoglobin, education, Thiazide, Aged, Pharmacology, Heart Failure, Renal Physiology, business.industry, Biology and Life Sciences, Proteins, Emergency department, Cardiovascular Disease Risk, Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: Author(s): Abensur Vuillaume, Laure; Ferreira, Joao Pedro; Asseray, Nathalie; Trombert-Paviot, Beatrice; Montassier, Emmanuel; Legrand, Matthieu; Girerd, Nicolas; Boivin, Jean-Marc; Chouihed, Tahar; Rossignol, Patrick | Abstract: BackgroundPotassium disturbances are associated with adverse prognosis in patients with chronic conditions. Its prognostic implications in stable patients attending the emergency department (ED) is poorly described.AimsThis study aimed to assess the prevalence of dyskalemia, describe its predisposing factors and prognostic associations in a population presenting the ED without unstable medical illness.MethodsPost-hoc analysis of a prospective, cross-sectional, multicenter study in the ED of 11 French academic hospitals over a period of 8 weeks. All adults presenting to the ED during this period were included, except instances of self-drug poisoning, inability to complete self-medication questionnaire, presence of an unstable medical illness and decline to participate in the study. All-cause hospitalization or deaths were assessed.ResultsA total of 1242 patients were included. The mean age was 57.2±22.3 years, 51% were female. The distribution according to potassium concentrations was: hypokalemial4mmol/L(n = 620, 49.9%), normokalemia 4-5mmol/L(n = 549, 44.2%) and hyperkalemia g5mmol/L(n = 73, 0,6%). The proportion of patients with a kalemial3.5mmol/L was 8% (n = 101). Renal insufficiency (OR [95% CI] = 3.56[1.94-6.52], p-value l0.001) and hemoglobin l12g/dl (OR [95% CI] = 2.62[1.50-4.60], p-value = 0.001) were associated with hyperkalemia. Female sex (OR [95% CI] = 1.31[1.03-1.66], p-value = 0.029), age l45years (OR [95% CI] = 1.69 [1.20-2.37], p-value = 0.002) and the use of thiazide diuretics (OR [95% CI] = 2.04 [1.28-3.32], p-value = 0.003), were associated with hypokalemial4mmol/l. Two patients died in the ED and 629 (52.7%) were hospitalized. Hypokalemia l3.5mmol/L was independently associated with increased odds of hospitalization or death (OR [95% CI] = 1.47 [1.00-2.15], p-value = 0.048).ConclusionsHypokalemia is frequently found in the ED and was associated with worse outcomes in a low-risk ED population.
Published: 2020
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26. Sera of elderly obstructive sleep apnea patients alter blood–brain barrier integrity in vitro: a pilot study

Author: Frédéric Roche, Anne-Cloé Voirin, Sébastien Celle, Nathalie Perek, INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Clinical Physiology [Saint-Étienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), This work was supported by grants from Jean Monnet University of Saint Etienne (France) and grants from DRCI of Saint Etienne University Hospital (PHRC National and PHRC Regional), France., Bodescot, Myriam, Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne
Subjects: [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology, Male, Cell Membrane Permeability, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, lcsh:Medicine, Pilot Projects, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Cohort Studies, 0302 clinical medicine, Cytotoxic T cell, lcsh:Science, 0303 health sciences, Sleep Apnea, Obstructive, Multidisciplinary, Tight junction, Sleep apnea, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, 3. Good health, medicine.anatomical_structure, Mechanisms of disease, Blood-Brain Barrier, Female, medicine.symptom, medicine.medical_specialty, Neurophysiology, Blood–brain barrier, Article, Cell Line, 03 medical and health sciences, Downregulation and upregulation, Internal medicine, medicine, Humans, 030304 developmental biology, Aged, business.industry, lcsh:R, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Endothelial Cells, Hypoxia (medical), medicine.disease, In vitro, respiratory tract diseases, Obstructive sleep apnea, Endocrinology, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, ATP-Binding Cassette Transporters, lcsh:Q, business, 030217 neurology & neurosurgery
Abstract: Obstructive sleep apnea syndrome (OSAS) is characterized by repeated episodes of hypoxia during the night. The severity of the disorder can be evaluated using an apnea–hypopnea index (AHI). The physiological consequences are mainly cardiovascular and neuronal dysfunctions. One hypothesis to explain such associated neurological disorders is disruption of the blood–brain barrier (BBB), which protects the brain from endovascular cytotoxic compounds. We selected two subgroups of volunteers from the PROOF cohort study (France), a group of patients suffering newly diagnosed severe OSAS (AHI > 30/h) and a group showing no sleep apnea (AHI p
Published: 2020
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27. Organized breast cancer screening and shared decision making

Author: Gocko, Xavier Pierre Antoine, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Université de Lyon, and Béatrice Trombert
Subjects: Breast cancer, Néoplasme mammaire, Breast neoplasm, Prise de décision, Communication, Mass screening, Decision making, Cancer du sein, Dépistage de masse, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Context. Participating in organized breast cancer screening is part of a shared decision-making process with an intelligible, fair and appropriate information delivered. This process is based on the knowledge, representations and values of women and professionals. The controversies surrounding this screening complicate the decision-making for women. In this context, the National Cancer Institute (INCa) launched online the first citizen consultation on this screening in October 2015.Aims. This work sought to feed the shared decision-making process within the framework of screening by studying the information given to women around the world and in France. He also sought to understand what the knowledge and values were underlying the decision of women. It dealt with the main subject of controversy: the discrepancies around overdiagnosis rates.Methods. Two systematic reviews were carried out: the first analyzed the various information tools in the world and the second the methodological differences leading to the overdiagnosis rates discrepancies. The INCa and “Cancer rose” websites were analyzed using the prism of International Patient Decision Aids Standards criteria. Citizen consultation was analyzed in a mixed and sequential study (qualitative / netnography and quantitative / multiple correspondence analysis) in order to understand the decisions to participate or not.Results conclusions. Appropriate information moves away from "pinkwashing" and takes into account the emotions of women. For professionals, overdiagnosis leads to regaining scientific doubt and managing it.; Contexte. Participer au dépistage organisé du cancer du sein s’inscrit dans un processus de décision partagée avec une information délivrée claire loyale et appropriée. Ce processus repose sur les connaissances, les représentations et les valeurs des femmes et des professionnels. Les controverses autour de ce dépistage compliquent la décision des femmes. Dans ce contexte l’Institut national du cancer (INCa) a organisé la première concertation citoyenne sur ce dépistage en octobre 2015. Objectifs. Ce travail a cherché à nourrir le processus de décision partagée dans le cadre du dépistage en étudiant l’information faite aux femmes dans le monde et en France. Il a aussi cherché à comprendre quelles étaient les connaissances et valeurs à la base de la décision des femmes. Il s’est intéressé au principal sujet de polémique : les divergences autour des taux de surdiagnostics. Méthodes. Deux revues systématiques de la littérature ont été réalisées : la première a analysé les différents outils d’information dans le monde et la deuxième les différences méthodologiques conduisant aux divergences de taux de surdiagnostics. Les sites de l’INCa et de Cancer rose ont été analysés avec le prisme des critères internationaux d’outils d’aide à la décision. La concertation citoyenne a été analysée de façon mixte et séquentielle (qualitative/netnographie et quantitative/analyse de correspondance multiple) afin de comprendre les décisions de participer ou non. Résultats-conclusions. L’information appropriée s’éloigne du « pinkwashing » et prend en compte les émotions des femmes. Pour les professionnels, les surdiagnostics conduisent à se réapproprier le doute scientifique et à le gérer.
Published: 2020

28. Dépistage organisé du cancer du sein et décision partagée

Author: Gocko, Xavier Pierre Antoine, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Université de Lyon, Béatrice Trombert, and STAR, ABES
Subjects: [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Breast cancer, Néoplasme mammaire, Breast neoplasm, Prise de décision, Communication, Mass screening, Decision making, Cancer du sein, Dépistage de masse, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Context. Participating in organized breast cancer screening is part of a shared decision-making process with an intelligible, fair and appropriate information delivered. This process is based on the knowledge, representations and values of women and professionals. The controversies surrounding this screening complicate the decision-making for women. In this context, the National Cancer Institute (INCa) launched online the first citizen consultation on this screening in October 2015.Aims. This work sought to feed the shared decision-making process within the framework of screening by studying the information given to women around the world and in France. He also sought to understand what the knowledge and values were underlying the decision of women. It dealt with the main subject of controversy: the discrepancies around overdiagnosis rates.Methods. Two systematic reviews were carried out: the first analyzed the various information tools in the world and the second the methodological differences leading to the overdiagnosis rates discrepancies. The INCa and “Cancer rose” websites were analyzed using the prism of International Patient Decision Aids Standards criteria. Citizen consultation was analyzed in a mixed and sequential study (qualitative / netnography and quantitative / multiple correspondence analysis) in order to understand the decisions to participate or not.Results conclusions. Appropriate information moves away from "pinkwashing" and takes into account the emotions of women. For professionals, overdiagnosis leads to regaining scientific doubt and managing it., Contexte. Participer au dépistage organisé du cancer du sein s’inscrit dans un processus de décision partagée avec une information délivrée claire loyale et appropriée. Ce processus repose sur les connaissances, les représentations et les valeurs des femmes et des professionnels. Les controverses autour de ce dépistage compliquent la décision des femmes. Dans ce contexte l’Institut national du cancer (INCa) a organisé la première concertation citoyenne sur ce dépistage en octobre 2015. Objectifs. Ce travail a cherché à nourrir le processus de décision partagée dans le cadre du dépistage en étudiant l’information faite aux femmes dans le monde et en France. Il a aussi cherché à comprendre quelles étaient les connaissances et valeurs à la base de la décision des femmes. Il s’est intéressé au principal sujet de polémique : les divergences autour des taux de surdiagnostics. Méthodes. Deux revues systématiques de la littérature ont été réalisées : la première a analysé les différents outils d’information dans le monde et la deuxième les différences méthodologiques conduisant aux divergences de taux de surdiagnostics. Les sites de l’INCa et de Cancer rose ont été analysés avec le prisme des critères internationaux d’outils d’aide à la décision. La concertation citoyenne a été analysée de façon mixte et séquentielle (qualitative/netnographie et quantitative/analyse de correspondance multiple) afin de comprendre les décisions de participer ou non. Résultats-conclusions. L’information appropriée s’éloigne du « pinkwashing » et prend en compte les émotions des femmes. Pour les professionnels, les surdiagnostics conduisent à se réapproprier le doute scientifique et à le gérer.
Published: 2020

29. Physical activity types and risk of dementia in community-dwelling older people: the Three-City cohort

Author: Frédéric Roche, Catherine Helmer, Isabelle Carrière, David Hupin, Jean-François Dartigues, Claudine Berr, Bienvenue Bongue, Caroline Dupré, Centre Technique d'Appui et de Formation des Centres d'Examens de Santé (CETAF), CETAF, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and Carrière, Isabelle
Subjects: Male, lcsh:Geriatrics, SEPIA, LEHA, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Leisure Activities, Risk Factors, medicine, Dementia, Humans, 030212 general & internal medicine, Prospective Studies, Exercise, Aged, Aged, 80 and over, Proportional hazards model, business.industry, Physical activity, [SCCO.NEUR]Cognitive science/Neuroscience, Hazard ratio, Confounding, [SCCO.NEUR] Cognitive science/Neuroscience, Dose-response effect, Cohort, medicine.disease, 16. Peace & justice, Confidence interval, lcsh:RC952-954.6, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Observational study, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Independent Living, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Demography, Cohort study, Research Article
Abstract: Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated the different types of physical activity and household activities. Our objective was to analyze the links between two physical activity types and dementia in older people. Methods The study used data from the prospective observational Three-city cohort and included 1550 community-dwelling individuals aged 72 to 87 without dementia at baseline. Physical activity was assessed with the Voorrips questionnaire. Two sub-scores were calculated to assess household/transportation activities and leisure/sport activities. Restricted cubic spline and proportional hazard Cox models were used to estimate the non-linear exposure-response curve for the dementia risk and the appropriate activity level thresholds. Models were adjusted for possible confounders, including socio-demographic variables, comorbidities, depressive symptoms and APOE genotype. Results The median age was 80 years, and 63.6% of participants were women. After a median follow-up of 4.6 years, dementia was diagnosed in 117 participants (7.6%). An inverse J-shaped association was found between household/transportation physical activity sub-score and dementia risk, which means that the risk is lowest for the moderately high values and then re-increases slightly for the highest values. The results remained significant when this sub-score was categorized in three classes (low, moderate, and high), with hazard ratios (95% confidence interval) of 0.55 (0.35–0.87) and 0.62 (0.38–1.01) for moderate and high activity levels, respectively. No significant effect was found for leisure/sport activities. Conclusions The 5-year risk of dementia was significantly and negatively associated with the household/transportation activity level, but not with the leisure and sport activity sub-score. This highlights the importance of considering all physical activity types in 72 years or older people.
Published: 2020
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30. Inflammatory stress induced by a combination of cytokines (IL-6, IL-17, TNF-α) leads to a loss of integrity on bEnd.3 endothelial cells in vitro BBB model

Author: Nathalie Perek, Anne-Cloé Voirin, Frédéric Roche, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Biologie intégrative du tissu osseux, Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and CCSD, Accord Elsevier
Subjects: 0301 basic medicine, [SDV]Life Sciences [q-bio], Inflammation, Blood–brain barrier, Cell Line, Proinflammatory cytokine, Mice, 03 medical and health sciences, 0302 clinical medicine, Stress, Physiological, medicine, Animals, Cytotoxic T cell, Claudin-5, Transcellular, Molecular Biology, Tight junction, Interleukin-6, Tumor Necrosis Factor-alpha, Chemistry, General Neuroscience, Interleukin-17, Endothelial Cells, Cell biology, [SDV] Life Sciences [q-bio], 030104 developmental biology, medicine.anatomical_structure, Blood-Brain Barrier, Paracellular transport, Zonula Occludens-1 Protein, Cytokines, Encephalitis, ATP-Binding Cassette Transporters, Neurology (clinical), Interleukin 17, medicine.symptom, 030217 neurology & neurosurgery, Developmental Biology
Abstract: The brain is a complex organ protected by the blood-brain barrier (BBB), which also has a complex organization. To play its protective role, the BBB acts by limiting the paracellular passage of potentially cytotoxic compounds through tight junctions as well as limiting transcellular passage by efflux pumps (ABC transporters). In many conditions such as sleep apnea or Alzheimer's disease, there is chronic inflammation, resulting in the presence of pro-inflammatory cytokines in the bloodstream. The effect of this chronic inflammation on the integrity of the BBB has been studied mainly through a single inflammatory molecule; but in physiological and pathological conditions, it is a combination of inflammatory cytokines. We investigated the effect of three major pro-inflammatory cytokines (IL-17, IL-6, TNF-α) used alone or in combination on the integrity of an in vitro model of BBB. Our study showed 24 h of inflammatory stress led to a BBB’s opening, reflected by a significant increase of permeability, which was correlated to a significant decrease of tight junction protein expressions (ZO-1, claudin-5), involving a possible entry of cytotoxic compounds into the brain. To compensate the loss of integrity, one of defense mechanism of endothelial cells was efflux transport, which showed a significant increase in expression and functionality of ABC transport proteins (MRP-1, Pgp). This opening of the BBB was more important when pro-inflammatory cytokines were combined, which could be explained by the interaction between cytokines and the potentiation of their effect.
Published: 2020
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31. Information autour du dépistage organisé du cancer du sein. L’INCa et Cancer Rose répondent-ils aux critères des outils d’aide à la décision ?

Author: M. Fondacci, X. Gocko, C. Dibi, C. Plotton, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon
Subjects: 03 medical and health sciences, Epidemiology, [SDV]Life Sciences [q-bio], Public Health, Environmental and Occupational Health, 030501 epidemiology, 0305 other medical science
Abstract: Resume Position du probleme Les controverses autour du depistage organise du cancer du sein accentuent le besoin d’informations pour les femmes. En France, l’INCa est en charge de cette information. Le site Cancer Rose (CR) produit une autre information, estimant celle de l’INCa incomplete. L’objectif de cette etude etait de determiner si les sites de l’Inca et de CR repondaient aux criteres d’outils d’aide a la decision. Methode Les documents de l’INCa et de CR ont ete selectionnes puis analyses a l’aide des criteres de l’International Patient Decision Aid Standards (IPDAS). Chaque item a ete cote A (absent), P (present) ou I (incomplet). Resultats Le livret d’information et le dossier de presse pour l’INCa et la rubrique etudes pour CR etaient les documents repondants le plus aux criteres IPDAS. Le document repondant le moins a ces criteres etait la video pour l’INCa et le depliant d’informations pour Cancer Rose. Les videos sont des outils plus accessibles pour les personnes avec un plus faible niveau de litteratie en sante. La video de l’INCa ne presente pas les risques du depistage et celle de CR met l’accent sur les risques. Conclusion Ces documents n’ont pas ete evalues sur le plan de l’intelligibilite, de la clarte et de la lisibilite. Prendre en compte ces criteres limite les inegalites sociales et ameliore le niveau de litteratie en sante.
Published: 2020
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32. An innovative intermittent hypoxia model for cell cultures allowing fast P<scp>o</scp>2 oscillations with minimal gas consumption

Author: Anne Briançon-Marjollet, Mélanie Minoves, Brigitte Gonthier, Jean-Louis Pépin, Jessica Morand, Diane Godin-Ribuot, Morgane Chatard, Emeline Lemarié, Jan Polak, Frédéric Perriot, Jean-Baptiste Menut, Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2 ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Charles University [Prague] (CU), Briançon-Marjollet, Anne, Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), and Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne
Subjects: 0301 basic medicine, medicine.medical_specialty, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Physiology, chemistry.chemical_element, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 030204 cardiovascular system & hematology, Biology, Blood–brain barrier, Oxygen, Andrology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Functional studies, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Tumor hypoxia, Intermittent hypoxia, Cell Biology, Hypoxia (medical), Surgery, 030104 developmental biology, medicine.anatomical_structure, chemistry, Cell culture, medicine.symptom, Gas consumption
Abstract: Performing hypoxia-reoxygenation cycles in cell culture with a cycle duration accurately reflecting what occurs in obstructive sleep apnea (OSA) patients is a difficult but crucial technical challenge. Our goal was to develop a novel device to expose multiple cell culture dishes to intermittent hypoxia (IH) cycles relevant to OSA with limited gas consumption. With gas flows as low as 200 ml/min, our combination of plate holders with gas-permeable cultureware generates rapid normoxia-hypoxia cycles. Cycles alternating 1 min at 20% O2 followed by 1 min at 2% O2 resulted in Po2 values ranging from 124 to 44 mmHg. Extending hypoxic and normoxic phases to 10 min allowed Po2 variations from 120 to 25 mmHg. The volume of culture medium or the presence of cells only modestly affected the Po2 variations. In contrast, the nadir of the hypoxia phase increased when measured at different heights above the membrane. We validated the physiological relevance of this model by showing that hypoxia inducible factor-1α expression was significantly increased by IH exposure in human aortic endothelial cells, murine breast carcinoma (4T1) cells as well as in a blood-brain barrier model (2.5-, 1.5-, and 6-fold increases, respectively). In conclusion, we have established a new device to perform rapid intermittent hypoxia cycles in cell cultures, with minimal gas consumption and the possibility to expose several culture dishes simultaneously. This device will allow functional studies of the consequences of IH and deciphering of the molecular biology of IH at the cellular level using oxygen cycles that are clinically relevant to OSA.
Published: 2017
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33. Etude des conséquences d’un syndrome d’apnée obstructive du sommeil sur l’intégrité d’un modèle in vitro de barrière hématoencéphalique : les processus inflammatoires et hypoxiques associés

Author: Voirin, Anne-Cloé, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Université de Lyon, Frédéric Roche, and Nathalie Perek-Courbon
Subjects: ABC-transporteurs, Jonctions serrées, Modélisation in vitro, In vitro modeling, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Obstructive sleep apnea syndrome (OSA), Haemotencephalic barrier, Barrière hémaotencéphalique, Tight junctions, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Syndrome d’apnée obstructive du sommeil (SAOS), [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, ABC-transporters
Abstract: Obstructive sleep apnea syndrome (OSA) is a major public health issue. It’s defined as repeated upper airway collapse associated with enhanced cerebrovascular risk. Nowadays, the most effective treatment is a continuous positive airway pressure device, but long term compliance could be limited. In order to develop alternative therapies, it appears necessary to better understand the underlying deleterious mechanisms and their impacts on the central nervous system (CNS). In this thesis we hypothesize that neurodegenerative consequences of OSA are mainly related to an alteration of the blood-brain barrier (BBB). This barrier is composed of a tight endothelium, which is combined with brain compartment cells such as astrocytes, to limits the entry and/or promotes the exit of cytotoxic compounds, thus protecting the CNS. The first objective of this topic was to assess the individual impact of two underlying mechanisms of OSA, i.e. chronic intermittent hypoxia and persistent low-grade inflammation on the integrity of an in vitro BBB model. Finally, we have evaluated a "global" approach to OSA using patient sera to determinate the effect of circulating biomarkers on an in vitro BBB model. The tightness of the endothelium is evaluated by Na-Fl permeability measurements, as well as cell-ELISA for tight junction proteins and ABC-transporters expression. Finally a measurement of ABC-transporters activity was performed. We demonstrate a loss of BBB integrity due to different stresses. We show that intermittent hypoxia leads to cellular adaptation and the use of an inhibitor of the main recognized HIF-1 alpha pathway doesn’t induce a complete reversion on the integrity of the BBB. Then, other pathways would be involved in BBB alteration, such as inflammation. Therefore, we show inflammatory stress apply to our in-vitro BBB model lead a loss of integrity. Finally, we demonstrate that biomarkers of patient’s sera with severe OSA induce an increase in the permeability of our human BBB model. Those results confirm the complexity of OSA pathophysiology, and the importance of studying individual mechanisms for the search of new therapies.; Le syndrome d’apnée obstructive du sommeil (SAOS) est un enjeu majeur en santé publique. Il est défini par des collapsus répétés des voies aériennes supérieures associés à une majoration du risque cérébrovasculaire. A ce jour, le traitement le plus efficace est un dispositif de pression positive continue nocturne, dont l’observance à long terme est limitée. Afin de développer d’autres thérapeutiques, il est nécessaire de comprendre les mécanismes sous-jacents ainsi que leurs impacts au niveau du système nerveux central (SNC). Dans cette thèse nous sommes partis de l’hypothèse que les déficits cognitifs seraient liés à une altération de la barrière hématoencéphalique (BHE). Cette barrière est composée d’un endothélium étanche, qui est associé aux cellules du compartiment cérébral tel que les astrocytes, pour permettre de limiter l’entrée et/ou de favoriser la sortie de composés cytotoxiques, protégeant ainsi le SNC. Les cellules endothéliales sont reliées entre elles par des protéines de jonctions telles que ZO-1 et Claudin-5. Mais elles possèdent également un système de transports d’efflux actif, appartenant à la famille des ABC-transporteurs tel que MRP-1, P-gp, BCRP. L’objectif premier de cette thèse, fut d’évaluer l’impact individuel de deux mécanismes sous-jacents du SAOS, c’est-à-dire l’hypoxie intermittente chronique par l’intermédiaire de la voie HIF-1 et l’inflammation persistance de bas grade, via l’utilisation de cytokines proinflammatoires connues pour leurs implications dans le SAOS, et ceci sur l’intégrité d’un modèle de BHE. Enfin nous avons réalisé une approche translationnelle du SAOS grâce à l’utilisation de sérums de patients permettant de déterminer l’effet des biomarqueurs sériques sur un modèle de BHE in vitro. L’étanchéité de l’endothélium est évaluée par des mesures de perméabilité au Sodium fluorescéine, ainsi que des ELISA sur cellules entières d’expression des protéines de jonctions serrées et des ABC-transporteurs. Enfin une mesure de l’activité de ces ABC-transporteurs a été réalisée. Nous montrons une perte d’intégrité de la BHE suite aux différents stress. Nous montrons que l’hypoxie intermittente chronique entraine une possible adaptation cellulaire et que l’inhibition de la voie hypoxique ne permet pas d’annuler entièrement les conséquences de l’hypoxie sur l’intégrité de la BHE. Ainsi d’autres voies que HIF-1 interviendraient dans ce processus de perméabilité de la barrière telle que l’inflammation. Enfin notre étude confirme que les biomarqueurs sériques de patients atteint d’un SAOS, induisent une augmentation de la perméabilité de la BHE. Ces diverses observations confirment la complexité du SAOS, et l’importance de l’étude des mécanismes individuels pour la recherche de nouvelles thérapeutiques.
Published: 2019

34. Assessing pain in the postoperative period: Analgesia Nociception IndexTM versus pupillometry

Author: Serge Molliex, Frédéric Roche, Marie-Charlotte Vogler, Marjolaine Courbon, Alexandre Martins-Baltar, François Vassal, David Charier, Vincent Pichot, Daniel Zantour, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: education.field_of_study, business.industry, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Population, Tracheal intubation, Area under the curve, Confidence interval, 3. Good health, body regions, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, Nociception, 030202 anesthesiology, Anesthesia, medicine, General anaesthesia, Pupillary light reflex, education, business, Pupillometry
Abstract: Background Potential methods for objective assessment of postoperative pain include the Analgesia Nociception Index™ (ANI), a real-time index of the parasympathetic tone, the pupillary light reflex (PLR), and the variation coefficient of pupillary diameter (VCPD), a measure of pupillary diameter (PD) fluctuations. Until now, the literature is divided as to their respective accuracy magnitudes for assessing a patient's pain. The VCPD has been demonstrated to strongly correlate with pain in an obstetrical population. However, the pain induced by obstetrical labour is different, given its intermittent nature, than the pain observed during the postoperative period. The aim of the current study was to compare the respective values of these variables at VAS scores ≥4. Methods After approval by the Ethics Committee, 345 patients aged on average 50 (SD 17) yr (range: 18–91 yr) of age were included. The protocols of general anaesthesia and postoperative analgesia were left to the anaesthetist's discretion. Some 40 min after tracheal intubation, VAS, ANI, PD, PLR, and VCPD values were recorded. Results VCPD correlates more strongly (r=0.78) with pain as assessed with the VAS than ANI (r=−0.15). PD and PLR are not statistically correlated with VAS. The ability of VCPD to assess the pain of patients (VAS≥4) is strong [area under the curve (AUC): 0.92, confidence interval (CI): 0.89–0.95], and better than for ANI (AUC: 0.39, CI: 0.33–0.45). Conclusions Our study suggests that VCPD could be a useful tool for monitoring pain in conscious patients during the postoperative period. Clinical trial registration NCT 03267979.
Published: 2019
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35. Screening a portfolio of pathologies by subject profiling and medical test rationing

Author: Bienvenu Bongue, Vincent Augusto, Nilson Herazo-Padilla, Xiaolan Xie, Benjamin Dalmas, Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), and Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne
Subjects: National health, medicine.medical_specialty, Rationing, Decision tree, Preventive health, 02 engineering and technology, 3. Good health, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], 03 medical and health sciences, 0302 clinical medicine, Medical test, 0202 electrical engineering, electronic engineering, information engineering, medicine, Profiling (information science), Portfolio, 020201 artificial intelligence & image processing, Medical physics, 030212 general & internal medicine, Medical prescription, ComputingMilieux_MISCELLANEOUS
Abstract: Health preventive medical evaluation programs are strategies commonly implemented as part of national health prevention efforts. Two problems related with the implementation of such strategies are subject profiling and medical test selection. The amount of different types of information that have to be analyzed by physicians in the screening for pathologies and medical test prescription can be overwhelming and significantly increases the complexity of this problem. Two decision-tree-based approaches are proposed in this study for subject profiling and medical test rationing. The proposed models perform well in terms of prediction. Results show that the implementation of these approaches helps to profile consultants into healthy and unhealthy subjects which can be used to ration medical test and design policies for preventive health evaluation programs.
Published: 2019
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36. Does obstructive sleep apnea affect exercise capacity and the hemodynamic response to exercise? An individual patient data and aggregate meta-analysis

Author: Felipe X. Cepeda, Christopher E. Kline, Jérémy Raffin, Trent A. Hargens, Céline Chapelle, Frédéric Roche, Mathieu Berger, Frédéric Costes, Silvy Laporte, Jean-Claude Barthélémy, Camila F. Rizzi, David Hupin, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Biologie intégrative du tissu osseux, Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Médecine du Sport et Explorations Fonctionnelles [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], and CHU Clermont-Ferrand
Subjects: Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Haemodynamic response, [SDV]Life Sciences [q-bio], Affect (psychology), 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Heart Rate, Physiology (medical), Internal medicine, Health Status Indicators, Humans, Medicine, Exercise, Sleep Apnea, Obstructive, Exercise Tolerance, business.industry, Confounding, Hemodynamics, Apnea, VO2 max, Exercise capacity, medicine.disease, Obstructive sleep apnea, 030228 respiratory system, Neurology, Meta-analysis, Exercise Test, Cardiology, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: Summary Obstructive sleep apnea (OSA) has been linked to altered cardiovascular response to exercise. A systematic review and individual patient data (IPD) meta-analysis were conducted to assess whether OSA patients present reduced exercise capacity. PubMed, Embase and Web of Science were searched until September 2018. Studies which performed sleep recording in both OSA patients and controls and measured maximal oxygen consumption (VO2peak) via a maximal exercise test were included. IPD were provided for five trials upon the 18 eligible (N = 289) and a two-stage IPD meta-analysis model was used, allowing to standardize the apnea cutoff and adjust for confounders. IPD meta-analysis demonstrated that moderate to severe OSA patients had similar VO2peak (mean difference: −1.03 mL·kg−1 min−1; 95% CI: −3.82 to 1.76; p = 0.47) and cardiovascular response to exercise compared to mild or non-OSA patients. By contrast, aggregate data (AD) meta-analysis including the 13 trials for which IPD were unavailable (N = 605) revealed that VO2peak was reduced in OSA patients compared to controls (mean difference: −2.30 mL·kg−1 min−1; 95% CI: −3.96 to −0.63; p
Published: 2019
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37. Exercise Frequency Determines Heart Rate Variability Gains in Older People: A Meta-Analysis and Meta-Regression

Author: Bienvenu Bongue, Jean-Claude Barthélémy, Jérémy Raffin, Vincent Pichot, Mathieu Berger, Claude Montuy-Coquard, Antoine Da Costa, David Hupin, Remi Bouvier, Caroline Dupré, Alain Colvez, Léonard Féasson, Frédéric Roche, Thierry Busso, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Service de Physiologie Clinique et de l’Exercice, Faculté de Médecine Jacques Lisfranc, Service de Physiologie Clinique et de l Exercice, CHU Nord, Faculté de Medecine Jacques Lisfranc, Université Jean Monnet (Saint-Etienne), Unité de Myologie, Centre Référent Maladies Neuromusculaires Rares Rhône-Alpes, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Caisse Nationale Santé et Solidarité (CNSA), Caisse nationale de solidarité pour l’autonomie (CNSA), Centre Technique d'Appui et de Formation des Centres d'Examens de Santé (CETAF), CETAF, and Service de Physiologie Clinique et de l'Exercice, CHU Nord, Faculté de Médecine Jacques Lisfranc
Subjects: medicine.medical_specialty, Aging, Sports medicine, Population, Physical Therapy, Sports Therapy and Rehabilitation, 03 medical and health sciences, 0302 clinical medicine, Endurance training, Heart Rate, Heart rate, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Heart rate variability, Humans, Orthopedics and Sports Medicine, Meta-regression, 030212 general & internal medicine, education, ComputingMilieux_MISCELLANEOUS, Aged, Randomized Controlled Trials as Topic, education.field_of_study, business.industry, Regression analysis, 030229 sport sciences, 3. Good health, Endurance Training, Meta-analysis, Physical therapy, Regression Analysis, business
Abstract: Previous studies have suggested that exercise training improves cardiac autonomic drive in young and middle-aged adults. In this study, we discuss the benefits for the elderly. We aimed to establish whether exercise still increases heart rate variability (HRV) beyond the age of 60 years, and to identify which training factors influence HRV gains in this population. Interventional controlled and non-controlled studies were selected from the PubMed, Ovid, Cochrane and Google Scholar databases. Only interventional endurance training protocols involving healthy subjects aged 60 years and over, and measuring at least one heart rate global or parasympathetic index, such as the standard deviation of the normal-to-normal intervals (SDNN), total frequency power (Ptot), root mean square of successive differences between adjacent NN intervals (RMSSD), or high frequency power (HF) before and after the training intervention, were included. HRV parameters were pooled separately from short-term and 24 h recordings for analysis. Risks of bias were assessed using the Methodological Index for Non-Randomized Studies and the Cochrane risk of bias tool. A random-effects model was used to determine effect sizes (Hedges’ g) for changes, and heterogeneity was assessed using Q and I statistics. Twelve studies, seven of which included a control group, including 218 and 111 subjects, respectively (mean age 69.0 ± 3.2 and 68.6 ± 2.5), were selected for meta-analysis. Including the 12 studies demonstrated homogeneous significant effect sizes for short-term (ST)-SDNN and 24 h-SDNN, with effect sizes of 0.366 (95% CI 0.185–547) and 0.442 (95% CI 0.144–0.740), respectively. Controlled study analysis demonstrated homogeneous significant effect sizes for 24 h-SDNN with g = 0.721 (95% CI 0.184–1.257), and 24 h-Ptot with g = 0.731 (95% CI 0.195–1.267). Meta-regression analyses revealed positive relationships between ST-SDNN effect sizes and training frequency ( $${\text{Tau}}_{\text{res}}^{2}$$ = 0.000; $$I_{\text{res}}^{2}$$ = 0.000; p = 0.0462). This meta-analysis demonstrates a positive effect of endurance-type exercise on autonomic regulation in older adults. However, the selected studies expressed some risks of bias. We conclude that chronic endurance exercise leads to HRV improvements in a linear frequency–response relationship, encouraging the promotion of high-frequency training programmes in older adults.
Published: 2019
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38. Skin lesion imaging with line-field confocal optical coherence tomography

Author: Jonas Ogien, Jean Luc Perrot, Pietro Rubegni, Elisa Cinotti, Josep Malvehy, Véronique del Marmol, Marianno Suppa, Anaïs Barut, David Siret, Hicham Azimani, Olivier Levecq, Maxime Cazalas, Arnaud Dubois, Laboratoire Charles Fabry / Biophotonique, Laboratoire Charles Fabry (LCF), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Hospital Clínic de Barcelona, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), and Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne
Subjects: [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Materials science, medicine.diagnostic_test, genetic structures, Confocal, Resolution (electron density), medicine.disease, 01 natural sciences, eye diseases, law.invention, 010309 optics, 030207 dermatology & venereal diseases, 03 medical and health sciences, Line field, 0302 clinical medicine, Structural mapping, Optical coherence tomography, Confocal microscopy, law, 0103 physical sciences, medicine, sense organs, Skin cancer, Skin lesion, Biomedical engineering
Abstract: An improved optical coherence tomography (OCT) technique called line-field confocal OCT (LC-OCT) has been developed for high-resolution skin imaging. Combining the principles of time-domain OCT and confocal microscopy with line illumination and detection, LC-OCT acquires multiple A-scans in parallel with dynamic focusing. With a quasi isotropic resolution of ∼ 1 μm, the LC-OCT images reveal a comprehensive structural mapping of skin, in vivo, at the cellular level down to a depth of ∼ 500 μm. LC-OCT images of various skin lesions, including carcinomas and melanomas, are found to well correlate with histopathological images. LC-OCT could significantly improve clinical diagnostic accuracy, while reducing the number of biopsies of benign lesions.
Published: 2019
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39. Quadriceps Endurance Increases Following Cycling Exercise With Non-Invasive Ventilation In Moderate-To-Severe COPD Patients. A Non-Randomized Controlled Study

Author: Frédéric Costes, Léonard Féasson, Mathieu Berger, Isabelle Court Fortune, Samuel Verges, Pierre Labeix, Physiologie Clinique et Exercice, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), EA 7424, Laboratoire Interuniversitaire Biologie Motricité, Université de Lyon, Université Jean Monnet - Saint-Étienne (UJM), Système Nerveux Autonome, Epidémiologie, Physiologie, Ingénierie, Santé (SNA- EPIS), Pneumologie & Oncologie Thoracique, HP2 Laboratoire d'Hypoxie et Physiopathologie Cardiovasculaire et Respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Grenoble, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Médecine du Sport et Explorations Fonctionnelles, CHU Clermont-Ferrand, Association Lyonnaise de Logistique Posthospitaliere, Lyon, France, Costes, Frédéric, ProdInra, Archive Ouverte, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Université Jean Monnet (Saint-Etienne), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Centre Hospitalier Universitaire de Clermont-Ferrand
Subjects: Male, Time Factors, Copd patients, medicine.medical_treatment, Pneumologie et système respiratoire, Severity of Illness Index, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Quadriceps Muscle, law.invention, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Randomized controlled trial, law, 030212 general & internal medicine, Respiratory system, Lung, Original Research, endurance, COPD, Exercise Tolerance, exercise, non-invasive ventilation, General Medicine, Middle Aged, Exercise Therapy, 3. Good health, Treatment Outcome, Breathing, Cardiology, Female, Cycling, Moderate to severe, medicine.medical_specialty, limb muscle, macromolecular substances, International Journal of Chronic Obstructive Pulmonary Disease, 03 medical and health sciences, Internal medicine, medicine, Humans, Pulmonary rehabilitation, Pulmonology and respiratory tract, Aged, lcsh:RC705-779, Noninvasive Ventilation, business.industry, copd, Recovery of Function, lcsh:Diseases of the respiratory system, medicine.disease, Bicycling, respiratory tract diseases, 030228 respiratory system, non invasive ventilation, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, business
Abstract: Pierre Labeix,1,2 Mathieu Berger,3 Isabelle Court Fortune,4 Léonard Feasson,2,5 Samuel Verges,6 Frédéric Costes7,8 1Centre VISAS, Service de Physiologie Clinique et de l’Exercice, CHU St Etienne, France; 2Univ Lyon, UJM Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricité, EA 7424, Saint-Etienne F-42023, France; 3Univ Lyon, UJM Saint-Etienne, laboratoire SNA-EPIS, EA4607, Saint-Etienne, France; 4Service de Pneumologie et d’Oncologie Thoracique, CHU St Etienne, France; 5Unité de Myologie, CHU St Etienne, France; 6Université Grenoble Alpes, Inserm, Laboratoire HP2, Grenoble, France; 7Université Clermont Auvergne, INRA, UNH Clermont Ferrand, France; 8Service de Médecine du Sport et des Explorations Fonctionnelles, CHU Clermont Ferrand, FranceCorrespondence: Frédéric CostesService de Médecine du Sport et des Explorations Fonctionnelles CHU Gabriel Montpied, 58 rue Montalembert, F63002 Clermont Ferrand cedex 1, FranceTel +33473751665Email fcostes@chu-clermontferrand.frPurpose: Application of non-invasive ventilation (NIV) during exercise improves exercise tolerance in severe COPD patients; however, the underlying mechanism is only partially unraveled. As part of its known effect to unload the respiratory muscles, we looked for the influence of NIV on post-exercise quadriceps muscle endurance.Patients and methods: We included 25 severe COPD patients entering an outpatient pulmonary rehabilitation program. They performed, on successive days, three quadriceps endurance tests at 70% of the maximal strength (1RM) to task failure (TlimQ); 1) control condition; 2) following constant load cycling exercise to exhaustion without Inspiratory Pressure Support (TlimQ IPS-); 3) following the same cycling exercise with IPS (TlmQ IPS+).Results: Dyspnea Borg score was significantly reduced at the end of the constant load cycling exercise with IPS+ compared to IPS- (3.5±2.6 to 4.3±2.3, p
Published: 2019
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40. Early polysomnographic characteristics associated with neurocognitive development at 36 months of age

Author: Hugues Patural, Jian-Sheng Lin, Patricia Franco, Sophie Flori, Aurore Guyon, F. Bat-Pitault, Sabine Plancoulaine, Camille Stagnara, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiologie integrée du système d'éveil, Université de Lyon-Université de Lyon-IFR19-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)
Subjects: Male, medicine.medical_specialty, Polysomnography, Population, Audiology, Arousal, Cohort Studies, 03 medical and health sciences, Child Development, Cognition, 0302 clinical medicine, arousal, medicine, cohort study, preschoolers, Humans, sleep, 10. No inequality, education, Intelligence Tests, Pregnancy, education.field_of_study, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, medicine.diagnostic_test, Intelligence quotient, business.industry, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, General Medicine, medicine.disease, Sleep in non-human animals, infant, 030228 respiratory system, Child, Preschool, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, intelligence quotient, business, Neurocognitive, 030217 neurology & neurosurgery, Cohort study
Abstract: Background Few studies on the relationship between sleep quantity and/or quality and cognition have been conducted among preschoolers from the healthy general population. We aimed to identify, among 3-year-old children, early polysomnography (PSG) sleep factors associated with estimated intelligence quotient (IQ) using the Weschler Preschool and Primary Scale Intelligence-III test (WPPSI-III) and its indicators: full-scale (FISQ), verbal (VIQ), and performance (PIQ) intelligence quotients. Methods We included full-term children from the French birth-cohort AuBE with PSG recording at term (M0) and/or six months (M6), and available WPPSI-III scores at three years. Sleep and arousal characteristics of these infants were evaluated during day and night sleep periods. Relationships between IQ scores and sleep parameters were estimated using models with the child as a repeated effect adjusted for time (night/day), maturation (M0/M6), tobacco exposure (yes/no), anxiety-depressive scores during pregnancy, maternal age, duration of breastfeeding and child's gender. Results A total of 118 PSG recordings were obtained, representing a total of 78 unique children (38 with one PSG and 40 with two PSG). No correlations were found between night and day sleep durations at M0 or M6. Mean VIQ, PIQ, and FSIQ scores were within normal ranges. In multivariate models, longer sleep duration and higher sleep efficiency during the day were negatively associated with all IQ scores. More frequent arousals during the night were associated with lower VIQ scores. Conclusion Early sleep characteristics such as night sleep fragmentation or longer naps could be associated with impaired cognitive function at three years of age.
Published: 2019
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41. Study of the consequences of obstructive sleep apnea syndrome on the integrity of an in vitro blood-brain barrier model : the inflammatory and hypoxic processes associated

Author: Voirin, Anne-Cloé, STAR, ABES, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Université de Lyon, Frédéric Roche, and Nathalie Perek-Courbon
Subjects: Modélisation in vitro, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, In vitro modeling, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Obstructive sleep apnea syndrome (OSA), [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Barrière hémaotencéphalique, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Syndrome d’apnée obstructive du sommeil (SAOS), ABC-transporters, ABC-transporteurs, Jonctions serrées, Haemotencephalic barrier, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Tight junctions, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Obstructive sleep apnea syndrome (OSA) is a major public health issue. It’s defined as repeated upper airway collapse associated with enhanced cerebrovascular risk. Nowadays, the most effective treatment is a continuous positive airway pressure device, but long term compliance could be limited. In order to develop alternative therapies, it appears necessary to better understand the underlying deleterious mechanisms and their impacts on the central nervous system (CNS). In this thesis we hypothesize that neurodegenerative consequences of OSA are mainly related to an alteration of the blood-brain barrier (BBB). This barrier is composed of a tight endothelium, which is combined with brain compartment cells such as astrocytes, to limits the entry and/or promotes the exit of cytotoxic compounds, thus protecting the CNS. The first objective of this topic was to assess the individual impact of two underlying mechanisms of OSA, i.e. chronic intermittent hypoxia and persistent low-grade inflammation on the integrity of an in vitro BBB model. Finally, we have evaluated a "global" approach to OSA using patient sera to determinate the effect of circulating biomarkers on an in vitro BBB model. The tightness of the endothelium is evaluated by Na-Fl permeability measurements, as well as cell-ELISA for tight junction proteins and ABC-transporters expression. Finally a measurement of ABC-transporters activity was performed. We demonstrate a loss of BBB integrity due to different stresses. We show that intermittent hypoxia leads to cellular adaptation and the use of an inhibitor of the main recognized HIF-1 alpha pathway doesn’t induce a complete reversion on the integrity of the BBB. Then, other pathways would be involved in BBB alteration, such as inflammation. Therefore, we show inflammatory stress apply to our in-vitro BBB model lead a loss of integrity. Finally, we demonstrate that biomarkers of patient’s sera with severe OSA induce an increase in the permeability of our human BBB model. Those results confirm the complexity of OSA pathophysiology, and the importance of studying individual mechanisms for the search of new therapies., Le syndrome d’apnée obstructive du sommeil (SAOS) est un enjeu majeur en santé publique. Il est défini par des collapsus répétés des voies aériennes supérieures associés à une majoration du risque cérébrovasculaire. A ce jour, le traitement le plus efficace est un dispositif de pression positive continue nocturne, dont l’observance à long terme est limitée. Afin de développer d’autres thérapeutiques, il est nécessaire de comprendre les mécanismes sous-jacents ainsi que leurs impacts au niveau du système nerveux central (SNC). Dans cette thèse nous sommes partis de l’hypothèse que les déficits cognitifs seraient liés à une altération de la barrière hématoencéphalique (BHE). Cette barrière est composée d’un endothélium étanche, qui est associé aux cellules du compartiment cérébral tel que les astrocytes, pour permettre de limiter l’entrée et/ou de favoriser la sortie de composés cytotoxiques, protégeant ainsi le SNC. Les cellules endothéliales sont reliées entre elles par des protéines de jonctions telles que ZO-1 et Claudin-5. Mais elles possèdent également un système de transports d’efflux actif, appartenant à la famille des ABC-transporteurs tel que MRP-1, P-gp, BCRP. L’objectif premier de cette thèse, fut d’évaluer l’impact individuel de deux mécanismes sous-jacents du SAOS, c’est-à-dire l’hypoxie intermittente chronique par l’intermédiaire de la voie HIF-1 et l’inflammation persistance de bas grade, via l’utilisation de cytokines proinflammatoires connues pour leurs implications dans le SAOS, et ceci sur l’intégrité d’un modèle de BHE. Enfin nous avons réalisé une approche translationnelle du SAOS grâce à l’utilisation de sérums de patients permettant de déterminer l’effet des biomarqueurs sériques sur un modèle de BHE in vitro. L’étanchéité de l’endothélium est évaluée par des mesures de perméabilité au Sodium fluorescéine, ainsi que des ELISA sur cellules entières d’expression des protéines de jonctions serrées et des ABC-transporteurs. Enfin une mesure de l’activité de ces ABC-transporteurs a été réalisée. Nous montrons une perte d’intégrité de la BHE suite aux différents stress. Nous montrons que l’hypoxie intermittente chronique entraine une possible adaptation cellulaire et que l’inhibition de la voie hypoxique ne permet pas d’annuler entièrement les conséquences de l’hypoxie sur l’intégrité de la BHE. Ainsi d’autres voies que HIF-1 interviendraient dans ce processus de perméabilité de la barrière telle que l’inflammation. Enfin notre étude confirme que les biomarqueurs sériques de patients atteint d’un SAOS, induisent une augmentation de la perméabilité de la BHE. Ces diverses observations confirment la complexité du SAOS, et l’importance de l’étude des mécanismes individuels pour la recherche de nouvelles thérapeutiques.
Published: 2019

42. Lyme borreliosis: evidence-based data useful for primary care

Author: Xavier, Gocko, Partouche, Henri, Lemogne, Cedric, Lenormand, Cedric, Bouiller, Kevin, Gehanno, Jean-Francois, Rabaud, Christian, Perrot, Serge, Roblot, France, Toubiana, Julie, Vuillemet, Francis, Christelle, Sordet, Cholley, Pascal, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Haut Conseil de la Santé Publique (HCSP), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Rouen, Normandie Université (NU), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service des maladies infectieuses [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Département de Pédiatrie et maladies infectieuses [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and CH Colmar
Subjects: [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

43. Associations between physical activity types and multi-domain cognitive decline in older adults from the Three-city cohort

Author: Frédéric Roche, Isabelle Carrière, Jean-François Dartigues, Claudine Berr, Catherine Helmer, Bienvenu Bongue, Caroline Dupré, CETAF, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM), Admin, Oskar, Centre Technique d'Appui et de Formation des Centres d'Examens de Santé (CETAF), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Carrière, Isabelle, and Institut des Neurosciences de Montpellier (INM)
Subjects: Male, Gerontology, Trail Making Test, Social Sciences, Blood Pressure, Neuropsychological Tests, Vascular Medicine, Benton Visual Retention Test, Executive Function, Cognition, Learning and Memory, Elderly, Endocrinology, Medical Conditions, 0302 clinical medicine, Sociology, Risk Factors, Medicine and Health Sciences, Verbal fluency test, Public and Occupational Health, Longitudinal Studies, Prospective Studies, 030212 general & internal medicine, Cognitive decline, Aged, 80 and over, Cognitive Impairment, Family Characteristics, Multidisciplinary, Cognitive Neurology, Executive functions, Neurology, Hypertension, Memory Recall, Medicine, Female, France, Independent Living, Psychology, Sports, Research Article, Cohort study, Endocrine Disorders, Cognitive Neuroscience, Science, Education, 03 medical and health sciences, Memory, Mental Health and Psychiatry, Diabetes Mellitus, Humans, Speech, Adults, Cognitive Dysfunction, Effects of sleep deprivation on cognitive performance, Exercise, Educational Attainment, Aged, Biology and Life Sciences, Physical Activity, Age Groups, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Metabolic Disorders, People and Places, Cognitive Science, Dementia, Population Groupings, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 030217 neurology & neurosurgery, Follow-Up Studies, Neuroscience
Abstract: International audience; Several studies suggest that physical activity improves cognitive functions and reduces cognitive decline, whereas others did not find any evidence of a neuroprotective effect. Furthermore, few cohort studies have analyzed the different physical activity types and particularly household activities. Our objective was to assess the association of two physical activity types with the decline in different cognitive domains in a large prospective cohort of community-dwelling older adults from the Three-city study. Physical activity (domestic/transportation activities and leisure/sport activities) was assessed with the Voorrips questionnaire, specific for older adults. Baseline sociodemographic and health history variables as well as cognitive performance data at baseline and during the 8-year follow-up (Mini-Mental State Examination, Benton Visual Retention Test, Trail Making Tests A and B, Isaac's Set Test and Free and Cued Selective Reminding Test) were also available. Associations between physical activity scores and cognitive decline in different domains were tested using minimally- and multi-adjusted linear mixed models. The analysis included 1697 participants without dementia at baseline and with at least one follow-up visit. At baseline, participants with higher sub-scores for the two physical activity types had better cognitive performances. Interaction with time showed that decline in some cognitive scores (Trail Making Test B and Isaac's Set Test) was significantly less pronounced in participants with higher household/transportation activity sub-scores. No significant effect over time was found for leisure/sport activities. This study shows that during an 8-year follow-up, executive functions and verbal fluency were better preserved in older adults who performed household/transportation activities at moderate to high level. Participation in domestic activities and using adapted transport means could allow older adults to maintain specific cognitive abilities.
Published: 2021
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44. Benefits of supervised community physical activity in obstructive sleep apnoea

Author: Mathieu Berger, Jérémy Raffin, David Hupin, Frédéric Costes, Frédéric Roche, Pierre Labeix, Jean-Michel Gaspoz, Caroline Dupré, Jean-Claude Barthélémy, Système Nerveux Autonome, Epidémiologie, Physiologie, Ingénierie, Santé (SNA- EPIS), Physiologie Clinique et Exercice, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Fédération française d'éducation physique et de gymnastique volontaire, Partenaires INRAE, Médecine du Sport et Explorations fonctionnelles, CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Hôpitaux Universitaires de Genève (HUG), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, education, MEDLINE, Physical activity, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Severity of Illness Index, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Severity of illness, medicine, Humans, Exercise, Aged, Sleep Apnea, Obstructive, business.industry, Sleep apnea, Middle Aged, medicine.disease, Sleep in non-human animals, respiratory tract diseases, 3. Good health, 030228 respiratory system, Physical therapy, Exercise Test, Female, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract: Supported by grants from the National Association of Research and Technology (ANRT) and the Federation Francaise d'Education Physique et de Gymnastique Volontaire (FFEPGV) through the CIFRE Convention #2014/0391, from the University Hospital of Saint-Etienne (AOL #2015/150833), and from the Adene group. The University Hospital of Saint-Etienne was the sponsor of the study. Funding information for this article has been deposited with the Crossref Funder Registry.; International audience; Obstructive sleep apnoea (OSA) is a chronic disorder characterised by repetitive episodes of partial or complete airway obstruction occurring during sleep [1]. Recent data suggest that moderate to severe OSA is highly prevalent, affecting up to 50% of men and 25% of women [2]. OSA is associated with frequent cardiovascular and cerebrovascular events [3]. Although continuous positive airway pressure (CPAP) is the gold standard treatment, long-term adherence remains poor, particularly in moderate and in non-sleepiness patients [4], while the cardiovascular risk remains high.
Published: 2018
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45. Exercise electrocardiogram in middle-aged and older leisure time sportsmen: 100 exercise tests would be enough to identify one silent myocardial ischemia at risk for cardiac event

Author: François Carré, Jean-Michel Guy, Frédéric Roche, David Hupin, Stéphane Doutreleau, Jean-Claude Barthélémy, Pascal Edouard, Pierre Abraham, Jari A. Laukkanen, Mathieu Oriol, Jean-Claude Chatard, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), CIC Saint Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Nord (Saint Etienne), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Hypoxie et physiopathologies cardiovasculaire et respiratoire, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine du sport [Rennes], CHU Pontchaillou [Rennes], Service de Physiologie Clinique et de l'Exercice, CHU Nord, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet (Saint-Etienne), Laboratoire de Physiologie, GIP Exercice, and Université Jean Monnet [Saint-Étienne] (UJM)
Subjects: Adult, Male, medicine.medical_specialty, Sports medicine, [SDV]Life Sciences [q-bio], Myocardial Ischemia, 030204 cardiovascular system & hematology, Sports Medicine, Asymptomatic, Sudden cardiac death, Coronary artery disease, Cohort Studies, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Risk Factors, Internal medicine, Medicine, Humans, Prospective Studies, Risk factor, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, business.industry, 030229 sport sciences, Odds ratio, Middle Aged, medicine.disease, 3. Good health, Cohort, Cardiology, Exercise Test, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Sports
Abstract: Background The importance of exercise electrocardiogram (ECG) has been controversial in the prevention of cardiac events among sportsmen. The aim of this study was to determine the frequency of silent myocardial ischemia (SMI) from an exercise ECG and its relationship with induced coronary angiographic assessment and potentially preventable cardiac events. Methods This prospective cohort study included leisure time asymptomatic sportsmen over 35years old, referred from 2011 to 2014 in the Sports Medicine Unit of the University Hospital of Saint-Etienne. Results Of the cohort of 1500 sportsmen (1205 men; mean age 50.7±9.4years; physical activity level 32.8±26.8MET-h/week), 951 (63%) had at least one cardiovascular disease (CVD) risk factor. Family history, medical examination and standard resting 12-lead were collected. A total of 163 exercise ECGs (10.9%) were defined as positive, most of them due to SMI (n=129, 8.6%). SMI was an indication for coronary angiography in 23 cases, leading to 17 documented SMIs (1.1%), including 11 significant stenoses requiring revascularization. In multivariate logistic regression analysis, a high risk of CVD (OR=2.65 [CI 95%: 1.33–5.27], p = 0.005 ) and an age >50years (OR=2.71 [CI 95%: 1.65–4.44], p 0.0001 ) were independently associated with confirmed SMI. Conclusions The association of positive exercise ECG with significant coronary stenosis was stronger among sportsmen with CVD risk factors and older than 50years. Screening by exercise ECG can lower the risk of cardiac events in middle-aged and older sportsmen. One hundred tests would be enough to detect one silent myocardial ischemia at risk for cardiac event.
Published: 2018
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46. Fifteen Minutes Daily Brisk Walk May Be a New Best Target in Very Old Adults: Age Is Not an Excuse to Not Exercise

Author: Remi Bouvier, Bienvenu Bongue, Nathalie Barth, Rémi Poillerat, Jérémy Raffin, Marc Thillays, Thierry Busso, Frédéric Roche, Léonard Féasson, Jean-Claude Barthélémy, Martin Garet, Claude Montuy-Coquard, Amandine Devun, David Hupin, Service de Physiologie Clinique et de l’Exercice, Faculté de Médecine Jacques Lisfranc, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), Unité de Myologie, Centre Référent Maladies Neuromusculaires Rares Rhône-Alpes, Unité de recherche clinique [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Centre Technique d'Appui et de Formation des Centres d'Examens de Santé (CETAF), CETAF, Service de Physiologie Clinique et de l'Exercice, CHU Nord, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet (Saint-Etienne), Laboratoire sur les Vulnérabilités et l'Innovation dans le Sport (EA 7428) (L-VIS), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon
Subjects: Adult, Male, Aging, medicine.medical_specialty, MEDLINE, Walking, 030204 cardiovascular system & hematology, [SHS]Humanities and Social Sciences, 03 medical and health sciences, 0302 clinical medicine, Cause of Death, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Medicine, 030212 general & internal medicine, Exercise, General Nursing, ComputingMilieux_MISCELLANEOUS, Aged, Cause of death, business.industry, Health Policy, General Medicine, Excuse, Walking Speed, Preferred walking speed, Physical therapy, Geriatrics and Gerontology, business
Abstract: International audience
Published: 2018
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47. Added value of 18 F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study

Author: Ceccaldi, Mathieu, Jonveaux, Thérèse, Verger, Antoine, Krolak-Salmon, Pierre, Houzard, Claire, Godefroy, Olivier, Shields, Trevor, Perrotin, Audrey, Gismondi, Rossella, Bullich, Santiago, Jovalekic, Aleksandar, Raffa, Nicola, Pasquier, Florence, Semah, Franck, Dubois, Bruno, Habert, Marie-Odile, Wallon, David, Chastan, Mathieu, Payoux, Pierre, Felician, Olivier, Didic, Mira, Gueriot, Claude, Koric, Lejla, Kletchkova-Gantchev, Radka, Andriuta, Daniela, Devendeville, Agnès, Dupuis, Diane, Binot, Ingrid, Barbay, Mélanie, Meyer, Marc-Etienne, Moullard, Véronique, Magnin, Eloi, Chamard, Ludivine, Haffen, Sophie, Drouet, Clément, Boulahdour, Hatem, Goas, Philippe, Querellou-Lefranc, Solène, de La Sayette, Vincent, Cogez, Julien, Branger, Pierre, Agostini, Denis, Manrique, Alain, Bejot, Yannick, Jacquin-Piques, Agnès, Dygai-Cochet, Inna, Berriolo-Riedinger, Alina, Moreaud, Olivier, Sauvee, Mathilde, Crépin, Céline, Bombois, Stéphanie, Lebouvier, Thibaud, Mackowiak-Cordoliani, Marie-Anne, Deramecourt, Vincent, Rollin-Sillaire, Adeline, Cassagnaud-Thuillet, Pascaline, Chen, Yaohua, Petyt, Grégory, Federico, Denis, Danaila, Keren, Guilhermet, Yves, Magnier, Christophe, Makaroff, Zaza, Rouch, Isabelle, Xie, Jing, Roubaud, Caroline, Coste, Marie-Hélène, David, Kenny, Sarciron, Alain, Waissi, Aziza, Scheiber, Christian, Gabelle-Deloustal, Audrey, Bennys, Karim, Marelli, Cecilia, Touati, Lynda, de Verbizier-Lonjon, Delphine, Benetos, Athanase, Kearney-Schwartz, Anna, Perret-Guillaume, Christine, Vercelletto, Martine, Boutoleau-Bretonniere, Claire, Pouclet-Courtemanche, Hélène, Wagemann, Nathalie, Pallardy, Amandine, Hugon, Jacques, Paquet, Claire, Dumurgier, Julien, Millet, Pascal, Queneau, Mathieu, Epelbaum, Stéphane, Levy, Marcel, Novella, Jean-Luc, Jaidi, Yacine, Morland, David, Belliard, Serge, Salmon, Anne, Lejeune, Florence, Hannequin, Didier, Martinaud, Olivier, Zarea, Aline, Pariente, Jérémie, Thalamas, Claire, Galitzky-Gerber, Monique, Tricoire Ricard, Anne-Marie, Calvas, Fabienne, Rigal, Emilie, Hitzel, Anne, Delrieu, Julien, Ousset, Pierre-Jean, Lala, Françoise, Sastre-Hengan, Nathalie, Morel, Olivier, Rouaud, Olivier, Mariano-Goulart, Denis, Papathanassiou, Dimitri, Le Jeune, Florence, Stephens, Andrew, Guedj, Eric, Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Gériatrie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Service de neurologie [Amiens], CHU Amiens-Picardie, Service de Médecine Nucléaire [Amiens], Piramal Imaging, Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), Troubles cognitifs vasculaires et dégénératifs, Université de Lille, Sciences et Technologies, Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] (IM2A), Sorbonne Université (SU), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-CRLCC Henri Becquerel, Toulouse Neuro Imaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie intégrative et adaptative (NIA), Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Service de neurologie et de neuropsychologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Université de Picardie Jules Verne (UPJV), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Université de Bourgogne (UB), Université de Lorraine (UL), Nanomédecine, imagerie, thérapeutique - UFC (EA 4662) (NIT / NANOMEDECINE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de neurologie, Centre Hospitalier Universitaire [Grenoble] (CHU), Service de Neurologie [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe coeur et ischémie, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Service de médecine nucléaire [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Optimisation - Système - Energie (GEPEA-OSE), Laboratoire de génie des procédés - environnement - agroalimentaire (GEPEA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Médecine Nucléaire, Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Service de Médecine Nucléaire, Centre Georges-François Leclerc [Dijon] (CGFL), Pôle Psychiatrie et Neurologie [Grenoble], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Neuroendocrinologie et physiopathologie neuronale, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Département de neurologie[Lille], Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital des Charpennes [CHU - HCL], CEA Le Ripault (CEA Le Ripault), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Unité de Gériatrie, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Centre Mémoire de Ressources et de Recherche (CMRR Lyon), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre Mutualiste de Réeducation Neurologique Propara (PROPARA), Languedoc Mutualité, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Gérontologie [CHRU Nancy], Clinique neurologique, Hôpital Laennec, Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Service de Médecine Nucléaire [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Neurologie Cognitive [Paris], Université Paris Diderot - Paris 7 (UPD7)-Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Parasitologie-Immunologie (EA 3677), Université Bordeaux Segalen - Bordeaux 2, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Hôpital de Reims - Service de neuro-gériatrie, Hôpital de Reims, Service de neurologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Service de médecine nucléaire [Rennes], CRLCC Eugène Marquis (CRLCC), Génétique médicale et fonctionnelle du cancer et des maladies neuropsychiatriques, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Institut National de la Santé et de la Recherche Médicale (INSERM), CIC - Biotherapie - Toulouse, CHU Clermont-Ferrand, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Gérontopôle, Department of Geriatrics, Centre Hospitalier Universitaire de Toulouse, Troubles cognitifs dégénératifs et vasculaires (U1171), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-INSERM, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Franche-Comté (UFC), École pratique des hautes études (EPHE)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc (CRLCC - CGFL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Université Paris Diderot - Paris 7 (UPD7)-Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Service d'Obstétrique et de Gynécologie [CHRU Nancy], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Comportement et noyaux gris centraux = Behavior and Basal Ganglia [Rennes], Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-CHU Pontchaillou [Rennes]-Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR), H. Lundbeck A/S, Novartis, Roche, Pfizer, Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-Institut Universitaire de Technologie - Nantes (IUT Nantes), Université de Nantes (UN)-Institut Universitaire de Technologie Saint-Nazaire (IUT Saint-Nazaire), Université de Nantes (UN)-Institut Universitaire de Technologie - La Roche-sur-Yon (IUT La Roche-sur-Yon), Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Université Bretagne Loire (UBL)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Université Bretagne Loire (UBL), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Pontchaillou [Rennes]-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université européenne de Bretagne - European University of Brittany (UEB)-Institut des Neurosciences Cliniques de Rennes (INCR)
Subjects: 0301 basic medicine, NATIONAL INSTITUTE, Pathology, Epidemiology, IMPACT, Amyloid pet, Clinical practice, BETA PLAQUES, 0302 clinical medicine, MESH: Stilbenes, Diagnosis, MESH: Aged, UTILITY, medicine.diagnostic_test, Health Policy, Alzheimer's disease, MESH: Dementia, MESH: Positron-Emission Tomography, 3. Good health, ALZHEIMERS-DISEASE, Psychiatry and Mental health, Positron emission tomography, Radiology, MESH: Radiopharmaceuticals, medicine.medical_specialty, CSF BIOMARKERS, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Amyloid imaging, 18F-florbetaben, MESH: Aniline Compounds, 03 medical and health sciences, Cellular and Molecular Neuroscience, MESH: Brain, Naturalistic observation, SCANS, Developmental Neuroscience, MESH: Diagnosis, Differential, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, MANAGEMENT, Dementia, Florbetaben, MESH: Amyloid, MESH: Humans, business.industry, medicine.disease, MESH: Male, MESH: France, 030104 developmental biology, Multicenter study, Etiology, Patient management, Neurology (clinical), Geriatrics and Gerontology, business, MESH: Female, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Introduction: Although some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal fluid analysis in a naturalistic setting.Methods: This multicenter study was performed at French tertiary memory clinics in patients presenting with most complex clinical situations (i.e., early-onset, atypical clinical profiles, suspected mixed etiological conditions, unexpected rate of progression), for whom cerebrospinal fluid analysis was indicated but either not feasible or considered as noncontributory (ClinicalTrials.gov: NCT02681172).Results: Two hundred five patients were enrolled with evaluable florbetaben PET scans; 64.4% of scans were amyloid positive. PET results led to changed diagnosis and improved confidence in 66.8% and 81.5% of patients, respectively, and altered management in 80.0% of cases.Discussion: High-level improvement of diagnostic certainty and management is provided by selective and hierarchical implementation of florbetaben PET into current standard practices for the most complex dementia cases. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.
Published: 2018
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48. Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

Author: Dufouil , Carole, Dubois , Bruno, Vellas , Bruno, Pasquier , Florence, Blanc , Frédéric, Hugon , Hugo, Hanon , Olivier, Dartigues , Jean-François, Harston , Sandrine, Gabelle , Audrey, Ceccaldi , Mathieu, Beauchet , Olivier, Krolak-Salmon , Pierre, David , David, Rouaud , Olivier, Godefroy , Olivier, Belin , Catherine, Rouch , Isabelle, Auguste , Nicolas, Wallon , David, Benetos , Athanase, Pariente , Jeremie, Paccalin , Marc, Moreaud , Olivier, Hommet , Caroline, Sellal , François, Boutoleau-Bretonnière , Claire, Jalenques , Isabelle, Gentric , Armelle, Vandel , Pierre, Azouani , Chabha, Fillon , Ludovic, Fischer , Clara, Savarieau , Helen, Operto , Grégory, Bertin , Hugo, Chupin , Marie, Bouteloup , Vincent, Habert , Marie-Odile, Mangin , Jean-François, Chêne , Geneviève, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Hématopoïèse normale et pathologique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Gustave Roussy (IGR)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de physique de la matière condensée (LPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Groupe hospitalier Broca, CHU Bordeaux [Bordeaux], Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Service de neurologie et de neuropsychologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire de Psychologie des Pays de la Loire (LPPL), Université d'Angers (UA)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN), Hospices Civils de Lyon (HCL), Centre Mémoire de Ressources et de Recherche [Nice] (CMRR Nice), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice), Laboratoire de génie des procédés - environnement - agroalimentaire (GEPEA), Mines Nantes (Mines Nantes)-Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre National de la Recherche Scientifique (CNRS), CHU Amiens-Picardie, Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), CHU Rouen, Normandie Université (NU), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Toulouse Neuro Imaging Center (ToNIC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Laboratoire de Psychologie et NeuroCognition (LPNC), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Imagerie et cerveau, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [Strasbourg], CHU Strasbourg-Hopital Civil, Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), CATI Multicenter Neuroimaging Platform (CATI), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université de Bordeaux (UB), Pôle de Santé publique [CHU Bordeaux], CHU de bordeaux, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Fédération des Centres Mémoire de Ressource et de Recherche du Sud de la France [CHU Toulouse] (F-CMRR-SF), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Mémoire de Ressources et de Recherche [Lille-Bailleul] (CMRR), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Hôpital Roger Salengro [Lille], Centre Mémoire de Ressources et de Recherches [Bordeaux], Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre de Mémoire de Ressources et de Recherche [Paris Nord], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Sorbonne Paris Cité (USPC), Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologies (EA 4468), Université Paris Descartes - Paris 5 (UPD5)-Groupe hospitalier Broca, Centre de Mémoire de Ressources et de Recherche [Paris Broca], AP-HP - Hôpital Broca [Paris], Centre de Mémoire de Ressources et de Recherche [Hôpital Pellegrin, Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin [Bordeaux], Centre de Mémoire de Ressources et de Recherche [Hôpital Xavier Arnozan, Bordeaux], Hôpital Xavier Arnozan - CHU de Bordeaux, Centres Mémoire de Ressources et de Recherche [Hôpital Gui de Chauliac, Montpellier] (CMRR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac, Centre de Mémoire de Ressources et de Recherche [Hôpital La Timone, Marseille], Hôpital de la Timone [CHU - APHM] (TIMONE)-CHU Marseille, Centre Mémoire de Ressources et de Recherche [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre Mémoire de Ressources et de Recherche [Lyon] (CMRR), Hospices Civils de Lyon (HCL)-Hôpital des Charpennes [CHU - HCL], Cognition Behaviour Technology (CobTek), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Centre Mémoire Ressources et Recherche [Dijon] (CMRR Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Mémoire de Ressources et de Recherche [CHU Amiens], Clinique de la Mémoire [Hôpitaux Universitaires Paris-Seine-Saint-Denis], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Mémoire de Ressources et de Recherche [CHU de Saint-Etienne Hôpital Nord], CHU de Saint-Étienne Hôpital Nord [Saint Etienne], Centre Mémoire de Ressources et de Recherche [CHU de Saint-Etienne Hôpital de la Charité], CHU de Saint-Étienne Hôpital la Charite, Service de neurologie [Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Centre Mémoire de Ressources et de Recherche [CHU de Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Mémoire [CHU de Toulouse], Centre Mémoire de Ressources et de Recherche [CHRU de Poitiers La Miletrie], CHRU de Poitiers La Miletrie [Poitiers], Centre Mémoire de Ressources et de Recherche [CHU Grenoble Alpes-Site NORD, La Tronche], CHU Grenoble Alpes - Site NORD [La Tronche], Centre Mémoire de Ressources et de Recherche [CHRU de Tours Hôpital Bretonneau], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau [Tours], Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Mémoire de Ressources et de Recherche [Hôpitaux Civils de Colmar, Strasbourg], Hôpitaux Civils de Colmar, Centre Mémoire de Ressources et de Recherche [CHU de Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Mémoire de Ressources et de Recherche [CHU Clermont-Ferrand] (CMRR), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Centre Mémoire de Ressources et de Recherche [CHRU de Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Mémoire de Ressources et de Recherche [CHRU de Besançon] (CMRR), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques [CHRU de Besançon], Centre pour l’Acquisition et le Traitement des Images [Saclay] (CATI), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut d'imagerie biomédicale (I²BM), Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay, The MEMENTO cohort was sponsored by the Fondation Plan Alzheimer (Alzheimer Plan 2008–2012). This work was also supported by the following : CIC 1401-EC, Bordeaux University Hospital, Inserm and the University of Bordeaux., on behalf of the MEMENTO cohort Study Group, BMC, BMC, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Mémoire de Ressources et de Recherche [CHU de Saint-Etienne] (CMRR 42), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM), Laboratoire d'Imagerie Biomédicale [Paris] (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Mines Nantes (Mines Nantes)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Laboratoire de Psychologie et NeuroCognition (LPNC ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut d'imagerie biomédicale (I²BM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire de Toulouse - CHU Toulouse-Hôpital La Grave-Casselardit [Toulouse], Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Hôpital Gui de Chauliac-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital des Charpennes [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice), Centre Mémoire de Ressources et de Recherche [CHU de Toulouse, Hôpital Purpan], Hôpital Purpan [Toulouse], Hôpital Bretonneau [Tours]-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), INSERM Unit 708-Neuroepidemiology, Paris, France, Institut de la Mémoire et de la Maladie d'Alzheimer [Paris] ( IM2A ), Université Pierre et Marie Curie - Paris 6 ( UPMC ), Epidémiologie et anlyses en santé publique: risques, maladies chroniques et handicaps, Université Paul Sabatier - Toulouse 3 ( UPS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Neurologie [Lille], Hôpital Roger Salengro-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Kalray, Service de gériatrie, Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ) -AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR99-ISPED, Institut de recherche en biothérapie ( IRB ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Université de Montpellier ( UM ), Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille ( APHM ) - Hôpital de la Timone [CHU - APHM] ( TIMONE ), Département de Médecine Interne et Gérontologie clinique, CHU Angers, Centre de recherche en neurosciences de Lyon ( CRNL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de génie des procédés - environnement - agroalimentaire ( GEPEA ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Nantes ( UN ) -IMT Atlantique Bretagne-Pays de la Loire ( IMT Atlantique ) -Université Bretagne Loire ( UBL ) -Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique ( ONIRIS ), Laboratoire de Neurosciences Fonctionnelles et Pathologies ( LNFP ), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique ( CNRS ), AP-HP Hôpital Avicenne [Bobigny], Centre Hospitalier Universitaire de Saint-Etienne ( CHU de Saint-Etienne ), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité ( RCV ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Imagerie cérébrale et handicaps neurologiques, Centre Mémoire de Ressources et de Recherche ( CM2R ), CHU de Poitiers-Hôpital Jean Bernard, Unité de Neuropsychologie, CHU Grenoble, Université de Tours-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Nantes ( UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes ) -Hôpital Nord Laënnec, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne ( NPsy-Sydo ), CHU Clermont-Ferrand-Université Clermont Auvergne ( UCA ), Service de Médecine Interne Gériatrique ( BREST - SMIG ), Centre Hospitalier Régional Universitaire de Brest ( CHRU Brest ), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre d'Acquisition et de Traitement des Images [Paris], Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Bordeaux population health ( BPH ), Université de Bordeaux ( UB ) -Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire Jacques-Louis Lions ( LJLL ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Epidemiologie-Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Bordeaux Ségalen [Bordeaux 2], Service de médecine nucléaire [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université de Bordeaux (UB), Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)-Hôpital Bretonneau [Tours], Centre Mémoire de Ressources et de Recherche [CHU de Clermont-Ferrand], CHU Clermont-Ferrand, Centre Mémoire de Ressources et de Recherche [CHRU de Besançon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Hôpital Jean Minjoz-Hôpital Saint-Jacques [CHRU de Besançon], Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Service NEUROSPIN (NEUROSPIN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut d'imagerie biomédicale (I²BM), Sorbonne Université, Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut d'imagerie biomédicale (I²BM), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Strasbourg (UNISTRA), Groupe hospitalier Pellegrin [Bordeaux] -CHU Bordeaux [Bordeaux], COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice)-Institut Claude Pompidou [Nice] (ICP - Nice)-Université Côte d'Azur (UCA), CHU Lille, CNRS, Inserm, Université de Lille, Troubles cognitifs dégénératifs et vasculaires - U1171, Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute ( ICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique ( CNRS ), Fédération des Centres Mémoire de Ressource et de Recherche du Sud de la France [CHU Toulouse] ( F-CMRR-SF ), Troubles cognitifs dégénératifs et vasculaires ( DN2M ), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ) -INSERM, Centre Mémoire de Ressources et de Recherche [Lille-Bailleul] ( CMRR ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ) -Hôpital Roger Salengro [Lille], Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie ( ICube ), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg ( ENGEES ) -Université de Strasbourg ( UNISTRA ) -Institut National des Sciences Appliquées - Strasbourg ( INSA Strasbourg ), Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Centre National de la Recherche Scientifique ( CNRS ) -Matériaux et nanosciences d'Alsace, Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Réseau nanophotonique et optique, Université de Strasbourg ( UNISTRA ) -Université de Haute-Alsace (UHA) Mulhouse - Colmar ( Université de Haute-Alsace (UHA) ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Université Sorbonne Paris Cité ( USPC ), Maladie d'Alzheimer : marqueurs génétiques et vasculaires, neuropsychologie ( EA 4468 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Groupe hospitalier Broca, Centre Hospitalier Universitaire de Bordeaux-Groupe hospitalier Pellegrin [Bordeaux], Centres Mémoire de Ressources et de Recherche [Hôpital Gui de Chauliac, Montpellier] ( CMRR ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ) -Hôpital Gui de Chauliac, Hôpital de la Timone [CHU - APHM] ( TIMONE ) -CHU Marseille, Centre Mémoire de Ressources et de Recherche [Lyon] ( CMRR ), Hospices Civils de Lyon ( HCL ) -Hôpital des Charpennes [CHU - HCL], Hospices Civils de Lyon ( HCL ), Cognition Behaviour Technology ( CobTek ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -CHU Nice-Institut Claude Pompidou [Nice] ( ICP - Nice ), Centre Mémoire de Ressources et de Recherche [Nice] ( CMRR Nice ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -CHU Nice, Centre Mémoire Ressources et Recherche [Dijon] ( CMRR Dijon ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), CHU Amiens Picardie - Site Nord (Hôpital Nord) [Amiens], CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Centre Hospitalier Régional Universitaire de Tours ( CHRU TOURS ) -Hôpital Bretonneau [Tours], Université de Strasbourg ( UNISTRA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre hospitalier universitaire de Nantes ( CHU Nantes ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Jean-Minjoz [CHRU de Besançon]-Hôpital Saint-Jacques [CHRU de Besançon], Centre pour l’Acquisition et le Traitement des Images [Saclay] ( CATI ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -NeuroSpin-Institut d'imagerie biomédicale (I²BM), Sorbonne Universités, Département de Médecine Nucléaire [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [APHP], Laboratoire d'Imagerie Biomédicale ( LIB ), and Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC )
Subjects: Male, [SDV]Life Sciences [q-bio], Neuroimaging, Neuropsychological Tests, Spinal Puncture, Pattern Recognition, Automated, [ SDV.NEU.PC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Diagnostic Self Evaluation, [ SDV.NEU.SC ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognitive aging, Fluorodeoxyglucose F18, Image Processing, Computer-Assisted, Humans, Cognitive Dysfunction, Longitudinal Studies, ComputingMilieux_MISCELLANEOUS, Aged, [ SDV ] Life Sciences [q-bio], Cohort studies, Natural history studies (prognosis), Alzheimer''s disease, Research, Brain, Organ Size, Magnetic Resonance Imaging, [SDV] Life Sciences [q-bio], Research Design, Positron-Emission Tomography, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [ SCCO.NEUR ] Cognitive science/Neuroscience, Female, France, Radiopharmaceuticals, Alzheimer’s disease, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies
Abstract: Background The natural history and disease mechanisms of Alzheimer’s disease and related disorders (ADRD) are still poorly understood. Very few resources are available to scrutinise patients as early as needed and to use integrative approaches combining standardised, repeated clinical investigations and cutting-edge biomarker measurements. Methods In the nationwide French MEMENTO cohort study, participants were recruited in memory clinics and screened for either isolated subjective cognitive complaints (SCCs) or mild cognitive impairment (MCI; defined as test performance 1.5 SD below age, sex and education-level norms) while not demented (Clinical Dementia Rating [CDR]
Published: 2017
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49. Does an observer's empathy influence my pain? Effect of perceived empathetic or unempathetic support on a pain test

Author: Camille Fauchon, Florian Chouchou, Vincent Pichot, I. Faillenot, Roland Peyron, A M Perrin, Luis Garcia-Larrea, Céline Borg, Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Université de Franche-Comté (UFC), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ingénierie, Recherche et Intervention, Sport Santé et Environnement (IRISSE), Université de La Réunion (UR), and Department of Neurology & Pain Center, CHU de Saint-Etienne, Saint-Etienne, France
Subjects: Adult, Male, Pain Threshold, medicine.medical_specialty, media_common.quotation_subject, Empathy, Audiology, Anger, medicine.disease_cause, 050105 experimental psychology, Developmental psychology, 03 medical and health sciences, Young Adult, 0302 clinical medicine, medicine, Heart rate variability, Humans, 0501 psychology and cognitive sciences, ComputingMilieux_MISCELLANEOUS, media_common, Pain Measurement, General Neuroscience, 05 social sciences, Pain Perception, Cognitive bias, Nociception, Feeling, Social Perception, Pain catastrophizing, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Irritation, Psychology, 030217 neurology & neurosurgery
Abstract: The physiological and behavioural effects of empathy for other's pain have been widely investigated, while the opposite situation, i.e. the influence on one's pain of empathetic feedback from others, remains largely unexplored. Here, we assessed whether and how empathetic and unempathetic comments from observers modulate pain and associated vegetative reactions. In Study 1, conversations between observers of a pain study were recorded by professional actors. Comments were prepared to be perceived as empathetic, unempathetic or neutral, and were validated in 40 subjects. In a subsequent pain experiment (Study 2), changes in subjective pain and heart rate were investigated in 30 naive participants who could overhear the empathetic or unempathetic conversations pre-recorded in study 1. Subjective pain was significantly attenuated when hearing empathetic comments, as compared to both unempathetic and neutral conditions, while unempathetic comments failed to significantly modulate pain. Heart rate increased when hearing unempathetic remarks and when receiving pain stimuli, but heart acceleration to nociceptive stimulation was not correlated with pain ratings. These results suggest that empathetic feedback from observers has a positive influence on pain appraisal and that this effect may surpass the negative effect of unempathetic remarks. Negative remarks can either trigger feelings of guilt or induce irritation/anger, with antagonistic effects on pain that might explain inter-individual variation. As in basal conditions heart rate and pain perception are positively correlated, their dissociation here suggests that changes in subjective pain were linked to a cognitive bias rather than changes in sensory input.
Published: 2017
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50. Contextual modulation of autonomic pain reactivity

Author: Camille Fauchon, Vincent Pichot, Luis Garcia-Larrea, I. Faillenot, Benjamin Pommier, Florian Chouchou, Roland Peyron, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé (SNA-EPIS), Université Jean Monnet - Saint-Étienne (UJM)-Centre Hospitalier Universitaire de Saint-Etienne, Service de Neurochirurgie [Saint Etienne], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Ingénierie, Recherche et Intervention, Sport Santé et Environnement (IRISSE), Université de La Réunion (UR), and Faillenot, Isabelle
Subjects: 0301 basic medicine, Adult, Male, Sympathetic Nervous System, Pain, Context (language use), Cardiac activity, Wavelet analysis, Cardiovascular control, Autonomic Nervous System, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Autonomic pain, Heart Rate, Medicine, Humans, Autonomic Pathways, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Reactivity (psychology), Heart rate variability, Pain Measurement, Endocrine and Autonomic Systems, business.industry, Heart, Visceral Pain, 030104 developmental biology, Nociception, Empathetic context, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery
Abstract: International audience; Although modulation of cardiac activity may be influenced by several factors, interaction between autonomic nociceptive responses and the high-level of cortical processes is not clearly understood. Here, we studied in 26 subjects whether empathetic or unempathetic contexts could interact with autonomic pain responses. RR intervals variability was used to approach parasympathetic and sympathetic responses to painful thermal stimulations, according to contexts evoked by experimenters' comments. We observed that unempathetic context increased sympathetic reactivity to comments and to painful stimulations without any parasympathetic change. These results show an interaction between context and nociceptive processes in cardiovascular control.
Published: 2017
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