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1. Preliminary evidence of an association between an interleukin 6 promoter polymorphism and self-reported attentional function in oncology patients and their family caregivers.

Author

Merriman, John, Aouizerat, Bradley, Langford, Dale, Cooper, Bruce, Baggott, Christina, Cataldo, Janine, Dhruva, Anand, Dunn, Laura, West, Claudia, Paul, Steven, Ritchie, Christine, Swift, Patrick, and Miaskowski, Christine

Subjects
attention, cancer, cytokines, genetic association studies, inflammation, radiotherapy, Aged, Attention, Caregivers, Family, Female, Humans, Interleukin-6, Male, Middle Aged, Neoplasms, Polymorphism, Single Nucleotide, Promoter Regions, Genetic
Abstract

Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare G allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.

Published
2014

2. A longitudinal study of measures of objective and subjective sleep disturbance in patients with breast cancer before, during, and after radiation therapy.

Author

Dhruva, Anand, Paul, Steven M, Cooper, Bruce A, Lee, Kathryn, West, Claudia, Aouizerat, Bradley E, Dunn, Laura B, Swift, Patrick S, Wara, William, and Miaskowski, Christine

Subjects
Humans, Breast Neoplasms, Karnofsky Performance Status, Longitudinal Studies, Predictive Value of Tests, Depression, Motor Activity, Sleep Stages, Adolescent, Adult, Aged, Middle Aged, Female, Young Adult, Actigraphy, Surveys and Questionnaires, Sleep Wake Disorders, Behavioral and Social Science, Clinical Research, Sleep Research, Cancer, Mental Health, Sleep, sleep disturbance, breast cancer, radiation therapy, hierarchical linear modeling, symptom trajectories, fatigue, depression, actigraphy, body mass index, Medical and Health Sciences, Anesthesiology
Abstract

ContextSleep disturbance is a significant problem in oncology patients.ObjectivesTo examine how actigraphy and self-report ratings of sleep disturbance changed over the course of and after radiation therapy (RT); investigate whether specific patient, disease, and symptom characteristics predicted the initial levels and/or the characteristics of the trajectories of sleep disturbance; and compare predictors of subjective and objective sleep disturbance.MethodsPatients (n=73) completed self-report questionnaires that assessed sleep disturbance, fatigue, depressive symptoms, anxiety, and pain before the initiation of RT through four months after the completion of RT. Wrist actigraphy was used as the objective measure of sleep disturbance. Hierarchical linear modeling was used for data analyses.ResultsMean wake after sleep onset was 11.9% and mean total score on the General Sleep Disturbance Scale was 45. More than 85% of the patients had an abnormally high number of nighttime awakenings. Substantial interindividual variability was found for both objective and subjective measures of sleep disturbance. Body mass index predicted baseline levels of objective sleep disturbance. Comorbidity, evening fatigue, and depressive symptoms predicted baseline levels of subjective sleep disturbance, and depressive symptoms predicted the trajectory of subjective sleep disturbance.ConclusionDifferent variables predicted sleep disturbance using subjective and objective measures. The slightly elevated wake after sleep onset found may be an underestimation of the degree of sleep disturbance when it is evaluated in the context of the high number of nighttime awakenings and patient's perception of poor sleep quality and quantity.

Published
2012

3. Changes in symptom clusters in patients undergoing radiation therapy

Author

Kim, Esther, Jahan, Thierry, Aouizerat, Bradley E., Dodd, Marylin J., Cooper, Bruce A., Paul, Steven M., West, Claudia, Lee, Kathryn, Swift, Patrick S., Wara, William, and Miaskowski, Christine

Subjects
Medicine & Public Health, Rehabilitation Medicine, Nursing Management/Nursing Research, Nursing, Oncology, Pain Medicine, Symptom clusters, Exploratory factor analysis, Breast cancer, Prostate cancer, Radiation therapy, Sickness behavior
Abstract

The goals of the study were to determine the occurrence rates for and the severity of symptoms at the middle, end, and 1 month after the completion of radiation therapy (RT), to determine the number and types of symptom clusters at these three time points, and to evaluate for changes over time in these symptom clusters.Symptom occurrence and severity were evaluated using the Memorial Symptom Assessment Scale (MSAS) in a sample of patients (n = 160) who underwent RT for breast or prostate cancer. At each time point, an exploratory factor analysis was done to determine the number of symptom clusters (i.e., symptom factors) based on the MSAS symptom severity ratings.The majority of the patients were male and married with a mean age of 61.1 years. The five symptoms with the highest occurrence rates across all three time points were lack of energy, pain, difficulty sleeping, feeling drowsy, and sweats. Although the number of symptoms and the specific symptoms within each symptom cluster were not identical across the three time points, three relatively similar symptom clusters (i.e., “mood-cognitive” symptom cluster, “sickness-behavior” symptom cluster, “treatment-related”, or “pain” symptom cluster) were identified in this sample. The internal consistency coefficients for the mood-cognitive symptom cluster and sickness-behavior symptom cluster were adequate at ≥0.68.Three relatively stable symptom clusters were found across RT. The majority of the symptom cluster severity scores were significantly higher in patients with breast cancer compared to patients with prostate cancer.

Published
2009

14. PSMA- and GRPR-Targeted PET: Results from 50 Patients with Biochemically Recurrent Prostate Cancer

Author

Baratto, Lucia, primary, Song, Hong, additional, Duan, Heying, additional, Hatami, Negin, additional, Bagshaw, Hilary P., additional, Buyyounouski, Mark, additional, Hancock, Steven, additional, Shah, Sumit, additional, Srinivas, Sandy, additional, Swift, Patrick, additional, Moradi, Farshad, additional, Davidzon, Guido, additional, and Iagaru, Andrei, additional

Published
2021
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16. Contributors

Author

Abitbol, Andre, primary, Abramson, David H., additional, Advani, Ranjana, additional, Ahmed, Mohammed, additional, Akin, Oguz, additional, Alektiar, Kaled M., additional, Alvarado, Michael, additional, Amols, Howard I., additional, Armstrong, John G., additional, Asselin, Barbara L., additional, Barani, Igor J., additional, Barker, Christopher A., additional, Beaulieu, Luc, additional, Bedford, Joel S., additional, Begg, Adrian C., additional, Bentzen, Søren M., additional, Bevan, Alison, additional, Bidaut, Luc M., additional, Blakely, Eleanor A., additional, Brown, J. Martin, additional, Burman, Chandra M., additional, Cahlon, Oren, additional, Callister, Matthew D., additional, Carroll, Peter, additional, Castro, Joseph R., additional, Chang, Daniel T., additional, Chang, Susan M., additional, Char, Devron H., additional, Chen, Allen M., additional, Chen, Andy, additional, Chen, Chien Peter, additional, Chi, Dennis S., additional, Chinnaiyan, Prakash, additional, Cho, Robert W., additional, Choi, Walter H., additional, Chong, Lanceford M., additional, Clark, Orlo H., additional, Clarke, Michael F., additional, Coakley, Fergus V., additional, Colevas, A. Dimitrios, additional, Constine, Louis S., additional, Coutre, Steven, additional, Culliney, Bruce, additional, Daftari, Inder K., additional, DeNardo, Sally J., additional, Diehn, Maximilian, additional, Donald, Paul J., additional, Dunkel, Ira J., additional, Dunphy, Mark, additional, Duska, Linda R., additional, Dutton, Sharon C., additional, Edwards, Michael S.B., additional, Farmer, Diana L., additional, Filion, Edith J., additional, Fischbein, Nancy J., additional, Fisher, George A., additional, Fisher, Paul Graham, additional, Ford, James M., additional, Fowble, Barbara, additional, Fu, Jennifer M., additional, Fu, Karen K., additional, Fuks, Zvi Y., additional, Gamo, Ignacio Azinovic, additional, Ganjoo, Kristen N., additional, Giaccia, Amato J., additional, Gibbs, Iris C., additional, Gillin, Michael T., additional, Ginsberg, Michelle S., additional, Goldsmith, Brian J., additional, Gomez, Daniel R., additional, Goodman, Karyn, additional, Gottschalk, Alexander R., additional, Graves, Edward E., additional, Green, Sheryl, additional, Grekin, Roy C., additional, Grewal, Ravinder K., additional, Gunderson, Leonard L., additional, Gutin, Philip H., additional, Haas-Kogan, Daphne A., additional, Haddock, Michael G., additional, Hammond, Ester M., additional, Harari, Paul M., additional, Harrison, Louis B., additional, Harshman, Lauren C., additional, Hayden, Melanie G. Gephart, additional, Hinerman, Russell W., additional, Ho, Alice Y., additional, Hoppe, Richard T., additional, Horning, Sandra J., additional, Hricak, Hedvig, additional, Hsu, Annie, additional, Hsu, I-Chow Joe, additional, Hu, Kenneth S., additional, Hudson, Melissa M., additional, Humm, John L., additional, Johannet, Peter, additional, Kaplan, Michael J., additional, Kapp, Daniel S., additional, Kashani-Sabet, Mohammed, additional, Katznelson, Laurence, additional, Kauff, Noah D., additional, Keall, Paul J., additional, Kim, Youn H., additional, King, Christopher R., additional, Knox, Susan J., additional, Koch, Cameron J., additional, Kollmeier, Marisa M., additional, Koong, Albert, additional, Krug, Lee M., additional, Kunz, Pamela L., additional, La Quaglia, Michael P., additional, Larson, David A., additional, Larson, Steven, additional, Laws, Edward R., additional, Le, Quynh-Thu, additional, Lee, Andrew K., additional, Lee, Nancy, additional, Li, Gloria C., additional, Lillis-Hearne, Patricia, additional, Ling, C. Clifton, additional, Linstadt, David E., additional, Loeffler, Jay S., additional, Loo, Billy W., additional, LoSasso, Thomas, additional, Mageras, Gikas S., additional, Margolis, Lawrence, additional, Marr, Brian P., additional, Matthay, Katherine K., additional, McBride, Sean M., additional, McCormick, Beryl, additional, McDermott, Michael W., additional, Melisko, Michelle, additional, Michaud, Karine, additional, Miller, Robert C., additional, Minsky, Bruce D., additional, Mishra, Kavita K., additional, Mohan, Radhe, additional, Myerson, Robert J., additional, Nag, Subir, additional, Nakamura, Jean L., additional, Narayana, Ashwatha, additional, Nori, Dattatreyudu, additional, Norton, Jeffrey A., additional, Orton, Colin G., additional, Parliament, Matthew B., additional, Petti, Paula L., additional, Phillips, Theodore Locke, additional, Pineda, Carlos E., additional, Pires, Isabel M., additional, Pouliot, Jean, additional, Presti, Joseph, additional, Quivey, Jeanne M., additional, Quon, Andrew, additional, Rabinovitch, Rachel, additional, Recht, Lawrence, additional, Reddy, Sunil A., additional, Rimner, Andreas, additional, Roach, Mack, additional, Rosenberg, Jonathan E., additional, Rosenthal, Seth A., additional, Rosenzweig, Kenneth E., additional, Rothenberg, Lawrence N., additional, Ruan, Daniel, additional, Russell, Anthony H., additional, Ryu, Janice, additional, Schefler, Amy C., additional, Schefter, Tracey E., additional, Schulz-Ertner, Daniela, additional, Schupak, Karen D., additional, Scruggs, Granger R., additional, Sessions, Roy B., additional, Shrieve, Dennis C., additional, Small, Eric J., additional, Sneed, Penny K., additional, Spierer, Marnee M., additional, Srinivas, Sandy, additional, Stauffer, Paul, additional, Stock, Richard G., additional, Sun, Xiaorong, additional, Swetter, Susan M., additional, Swift, Patrick S., additional, Tempero, Margaret A., additional, Tsujii, Hirohiko, additional, Tuniz, Francesco, additional, Urtasun, Raul C., additional, Venook, Alan P., additional, Verhey, Lynn J., additional, Wagman, Raquel, additional, Wallner, Kent, additional, Warren, Robert, additional, Weissman, Irving L., additional, Welton, Mark L., additional, Wharam, Moody D., additional, Wilson, George David, additional, Wilson, Paul F., additional, Wolden, Suzanne L., additional, Woo, Shiao Y., additional, Xia, Ping, additional, Xing, Lei, additional, Yahalom, Joachim, additional, Yamada, Yoshiya, additional, Yom, Sue S., additional, and Zelefsky, Michael J., additional

Published
2010
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17. Cancer of the Thyroid

Author

Swift, Patrick S., primary, Larson, Steven, additional, Clark, Orlo H., additional, and Ruan, Daniel, additional

Published
2010
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20. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid

Author

Matthay, Katherine K., Villablanca, Judith G., Seeger, Robert C., Stram, Daniel O., Harris, Richard E., Ramsay, Norma K., Swift, Patrick, Shimada, Hiroyuki, Black, C. Thomas, Brodeur, Garrett M., Gerbing, Robert B., and Reynolds, C. Patrick

Subjects
Neuroblastoma -- Care and treatment, Bone marrow -- Transplantation
Abstract

Autologous bone marrow transplants may be beneficial in children with neuroblastoma. Researchers treated 379 children with neuroblastoma with chemotherapy initially and then randomly assigned them to receive further chemotherapy or a bone marrow transplant. Three years later, 34% of those who received the bone marrow transplant were still alive compared to 22% of those who received chemotherapy. Children who took 13-cis-retinoic acid also survived longer than those who did not.

Published
1999

27. Dilemmas of human service reform in New Haven: integrating three levels of organizational analysis.

Author

Johnston, Paul, Rowe, Michael, and Swift, Patrick

Subjects
Social service -- Management -- Services, Homeless persons -- Services -- Analysis, Urban poor -- Services -- Analysis, Organizational research -- Analysis, Company business management
Abstract

Paul Johnston is an associate professor in the Sociology Department at Yale University (140 Prospect St., 1965 Yale Station, New Haven, CT 06520). He studies public organizations and is the [...], Researchers' access to a federal demonstration grant changed the goals of a New Haven homeless initiative from housing to drug treatment. The meaning of empowering clients changed from giving access to resources to fostering self-reliance. Modest treatment outcome results were attributed to failures in integrating services with other agencies.

Published
1995

29. Preliminary evidence of an association between an interleukin 6 promoter polymorphism and self-reported attentional function in oncology patients and their family caregivers.

Author

Merriman, John D, Merriman, John D, Aouizerat, Bradley E, Langford, Dale J, Cooper, Bruce A, Baggott, Christina R, Cataldo, Janine K, Dhruva, Anand, Dunn, Laura, West, Claudia, Paul, Steven M, Ritchie, Christine S, Swift, Patrick S, Miaskowski, Christine, Merriman, John D, Merriman, John D, Aouizerat, Bradley E, Langford, Dale J, Cooper, Bruce A, Baggott, Christina R, Cataldo, Janine K, Dhruva, Anand, Dunn, Laura, West, Claudia, Paul, Steven M, Ritchie, Christine S, Swift, Patrick S, and Miaskowski, Christine

Abstract

Subgroups of individuals may be at greater risk of cytokine-induced changes in attentional function. The purposes of this study were to identify subgroups of individuals with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) differences among these subgroups. Self-reported attentional function was evaluated in 252 participants (167 oncology patients and 85 family caregivers) using the Attentional Function Index before radiation therapy and at six additional assessments over 6 months. Three latent classes of attentional function were identified using growth mixture modeling: moderate (36.5%), moderate-to-high (48.0%), and high (15.5%) attentional function. Participants in the moderate class were significantly younger, with more comorbidities and lower functional status, than those in the other two classes. However, only functional status remained significant in multivariable models. Included in the genetic association analyses were 92 single nucleotide polymorphisms (SNPs) among 15 candidate genes. Additive, dominant, and recessive genetic models were assessed for each SNP. Controlling for functional status, only Interleukin 6 (IL6) rs1800795 remained a significant genotypic predictor of class membership in multivariable models. Each additional copy of the rare "G" allele was associated with a 4-fold increase in the odds of belonging to the lower attentional function class (95% confidence interval: [1.78, 8.92]; p = .001). Findings provide preliminary evidence of subgroups of individuals with distinct trajectories of attentional function and of a genetic association with an IL6 promoter polymorphism.

Published
2014

30. Traumatic Brain Injury

Author

Nielsen, Alexandra, primary, Im, Brian, additional, Hibbard, Mary R., additional, Grunwald, Ilana, additional, and Swift, Patrick T., additional

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31. Preliminary Evidence of an Association Between an Interleukin 6 Promoter Polymorphism and Self-Reported Attentional Function in Oncology Patients and Their Family Caregivers

Author

Merriman, John D., primary, Aouizerat, Bradley E., additional, Langford, Dale J., additional, Cooper, Bruce A., additional, Baggott, Christina R., additional, Cataldo, Janine K., additional, Dhruva, Anand, additional, Dunn, Laura, additional, West, Claudia, additional, Paul, Steven M., additional, Ritchie, Christine S., additional, Swift, Patrick S., additional, and Miaskowski, Christine, additional

Published
2013
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37. Differences in Sleep Disturbance and Fatigue Between Patients with Breast and Prostate Cancer at the Initiation of Radiation Therapy

Author

Garrett, Kristin, primary, Dhruva, Anand, additional, Koetters, Theresa, additional, West, Claudia, additional, Paul, Steven M., additional, Dunn, Laura B., additional, Aouizerat, Bradley E., additional, Cooper, Bruce A., additional, Dodd, Marylin, additional, Lee, Kathryn, additional, Wara, William, additional, Swift, Patrick, additional, and Miaskowski, Christine, additional

Published
2011
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39. Differences in Sleep Disturbance Parameters Between Oncology Outpatients and Their Family Caregivers

Author

Carney, Sara, primary, Koetters, Theresa, additional, Cho, Maria, additional, West, Claudia, additional, Paul, Steven M., additional, Dunn, Laura, additional, Aouizerat, Bradley E., additional, Dodd, Marylin, additional, Cooper, Bruce, additional, Lee, Kathryn, additional, Wara, William, additional, Swift, Patrick, additional, and Miaskowski, Christine, additional

Published
2011
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41. Preliminary Evidence of an Association Between a Functional Interleukin-6 Polymorphism and Fatigue and Sleep Disturbance in Oncology Patients and Their Family Caregivers

Author

Miaskowski, Christine, primary, Dodd, Marylin, additional, Lee, Kathryn, additional, West, Claudia, additional, Paul, Steven M., additional, Cooper, Bruce A., additional, Wara, William, additional, Swift, Patrick S., additional, Dunn, Laura B., additional, and Aouizerat, Bradley E., additional

Published
2010
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45. Differences in Symptom Clusters Identified Using Occurrence Rates Versus Symptom Severity Ratings in Patients at the End of Radiation Therapy

Author

Kim, Esther, primary, Jahan, Thierry, additional, Aouizerat, Bradley E., additional, Dodd, Marylin J., additional, Cooper, Bruce A., additional, Paul, Steven M., additional, West, Claudia, additional, Lee, Kathryn, additional, Swift, Patrick S., additional, Wara, William, additional, and Miaskowski, Christine, additional

Published
2009
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47. Trajectories of fatigue in family caregivers of patients undergoing radiation therapy for prostate cancer

Author

Fletcher, Barbara A. Swore, primary, Schumacher, Karen L., additional, Dodd, Marylin, additional, Paul, Steven M., additional, Cooper, Bruce A., additional, Lee, Kathryn, additional, West, Claudia, additional, Aouizerat, Bradley E., additional, Swift, Patrick S., additional, Wara, William, additional, and Miaskowski, Christine, additional

Published
2009
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49. Local stiffener and skin pocket buckling prediction by special PASCO modeling technique: Correlation to test data

Author

Yin, Dah N, Tran, Vu M, and Swift, Patrick M

Subjects
Structural Mechanics
Abstract

Waffle panels are often used on fuselage structures such as that of the Space Shuttle. The waffle panel design is an efficient design for carrying biaxial, in-plane, and shear loads. The WAFFLE program was designed for application on waffle panels. The Panel Analysis and Sizing Code (PASCO) program was designed for analyzing and sizing uniaxially stiffened panels. The application of the PASCO program in conjunction with the WAFFLE program is discussed to account for both the fillet radius and the presence of stiffness in both directions. The results of the tests are used to verify that these adjustments are valid and necessary if accurate analysis of the waffle panel is to be achieved.

Published
1989

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