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Objectives: The objective of this article is to study the effect of neuronavigation on the outcome of surgery for supratentorial tumors, such as the extent of resection, size of craniotomy, and overall morbidity and mortality by comparing with conventional excision. Methods: A total of 50 patients undergoing intracranial surgery for supratentorial space-occupying lesions from 2020 to 2022 were included in the study. One intervention group consisted of patients undergoing surgical resection of supratentorial tumors utilizing image guidance versus the control group, which consisted of patients undergoing surgical excision of supratentorial tumor excision without image guidance. Parameters used to compare the outcome were the extent of resection of the lesions, craniotomy size, and overall morbidity and mortality. Results and Conclusion: There was no significant reduction in craniotomy size or prolongation of operative duration with the use of neuronavigation. There was no significant difference in postoperative hospital stay between the two groups. Neuronavigation-assisted cases did not show any significant reduction in the occurrence of postoperative neurological deficits or any reduction of overall morbidity and mortality.

Objectives: The objective of this article is to study the effect of neuronavigation on the outcome of surgery for supratentorial tumors, such as the extent of resection, size of craniotomy, and overall morbidity and mortality by comparing with conventional excision. Methods: A total of 50 patients undergoing intracranial surgery for supratentorial space-occupying lesions from 2020 to 2022 were included in the study. One intervention group consisted of patients undergoing surgical resection of supratentorial tumors utilizing image guidance versus the control group, which consisted of patients undergoing surgical excision of supratentorial tumor excision without image guidance. Parameters used to compare the outcome were the extent of resection of the lesions, craniotomy size, and overall morbidity and mortality. Results and Conclusion: There was no significant reduction in craniotomy size or prolongation of operative duration with the use of neuronavigation. There was no significant difference in postoperative hospital stay between the two groups. Neuronavigation-assisted cases did not show any significant reduction in the occurrence of postoperative neurological deficits or any reduction of overall morbidity and mortality. [ABSTRACT FROM AUTHOR]

Brain relaxation is an important requirement in intracranial neurosurgical procedures and optimal brain relaxation improves the operating conditions. Optic nerve sheath diameter (ONSD) is a non-invasive bedside surrogate marker of intracranial pressure (ICP) status. Elevated ICP is often associated with marked autonomic dysfunction. There is no standard measure to predict intraoperative brain condition non-invasively, considering both anatomical displacement and physiological effects due to raised ICP and brain oedema. This study was aimed to determine the usefulness of heart rate variability (HRV) parameters and ONSD preoperatively in predicting intraoperative brain relaxation in patients with supratentorial tumors undergoing surgery.This prospective observational study was conducted in a tertiary care centre. 58 patients with supratentorial brain tumors undergoing elective surgery were studied. Preoperative clinical presentation, computed tomography (CT) findings, ONSD and HRV parameters were assessed in determining intraoperative brain condition. Intraoperative hemodynamic parameters and brain relaxation score after craniotomy were studied. There was significant difference in CT grade, ONSD and HRV parameters in patients between lax and tight brain. A receiver operating curve was constructed to determine the cut off to predict intraoperative brain bulge. A CT grade more than 2, ONSD of greater than 0.63 cms and ratio of low frequency to high ratio (LF/HF) of more than 1.8 were good predictors of brain bulge. The changes in ONSD and HRV parameters, with the CT findings can be used as surrogate markers of increased ICP to help predict intraoperative brain condition. [ABSTRACT FROM AUTHOR]

Abstract Background Satisfactory brain relaxation is essential in neurosurgery. Desflurane anesthesia and propofol-based total intravenous anesthesia (TIVA) have different effects on cerebral hemodynamics, potentially contributing to discrepant brain relaxation. The purpose of this study was to compare the effects of desflurane and TIVA on brain relaxation in patients undergoing craniotomy for supratentorial tumors. Methods In this randomized, controlled study, we enrolled patients aged 18–60 years, with ASA I–III, who were scheduled to undergo elective craniotomy for supratentorial tumors. Patients were randomly assigned in a 1:1 ratio to receive desflurane anesthesia or TIVA. The primary outcome was the proportion of satisfactory brain relaxation. Secondary outcomes included emergence and extubation times, recovery of cognitive function and postoperative complications. Results Of 369 patients who were assessed for eligibility, 111 were randomized and 110 were included in the modified intention-to-treat analysis (55 in the desflurane group and 55 in the TIVA group). The proportion of satisfactory brain relaxation was similar between the two groups: 69% in the desflurane group and 73% in the TIVA group (RR: 0.950, 95% CI: 0.748–1.207; P = 0.675). Patients assigned to the desflurane group had shorter emergence (10 [8–13] min vs. 13 [10–20] min, P

Background: Satisfactory brain relaxation is essential in neurosurgery. Desflurane anesthesia and propofol-based total intravenous anesthesia (TIVA) have different effects on cerebral hemodynamics, potentially contributing to discrepant brain relaxation. The purpose of this study was to compare the effects of desflurane and TIVA on brain relaxation in patients undergoing craniotomy for supratentorial tumors. Methods: In this randomized, controlled study, we enrolled patients aged 18–60 years, with ASA I–III, who were scheduled to undergo elective craniotomy for supratentorial tumors. Patients were randomly assigned in a 1:1 ratio to receive desflurane anesthesia or TIVA. The primary outcome was the proportion of satisfactory brain relaxation. Secondary outcomes included emergence and extubation times, recovery of cognitive function and postoperative complications. Results: Of 369 patients who were assessed for eligibility, 111 were randomized and 110 were included in the modified intention-to-treat analysis (55 in the desflurane group and 55 in the TIVA group). The proportion of satisfactory brain relaxation was similar between the two groups: 69% in the desflurane group and 73% in the TIVA group (RR: 0.950, 95% CI: 0.748–1.207; P = 0.675). Patients assigned to the desflurane group had shorter emergence (10 [8–13] min vs. 13 [10–20] min, P < 0.001) and extubation times (13 [10–18] min vs. 17 [13–23] min, P < 0.001), and better recovery of cognitive function at 15 min after extubation (16 [0–24] vs. 0 [0–20], P = 0.003), but experienced increased postoperative nausea and vomiting (PONV) (16 [29%] vs. 6 [11%] P = 0.017) and tachycardia (22 [40%] vs. 9 [16%], P = 0.006) during recovery. Conclusions: Desflurane anesthesia and TIVA provide similar brain relaxation in patients without intracranial hypertension undergoing elective craniotomy. Desflurane accelerates the recovery from anesthesia but is associated with increased PONV and tachycardia during the recovery period. Trial registration: Clinicaltrial.gov (NCT04691128). Date of registration: December 31, 2020. [ABSTRACT FROM AUTHOR]

Background The incidence of hyponatremia is high in supratentorial tumors. However, most studies of supratentorial tumors have included patients with sellar/suprasellar tumors. It is common knowledge that sellar tumors have higher incidence and severity of hyponatremia. Incidence of hyponatremia is not known if we exclude sellar/suprasellar tumors. Therefore, this study was designed to evaluate the incidence of hyponatremia in supratentorial tumors after excluding sellar/suprasellar tumors. Methods After institutional ethics committee approval and written informed consent, adult patients with supratentorial tumors (nonsellar/suprasellar) were recruited, and data were collected prospectively. In all patients, serum electrolytes were measured every 2 to 3 days. Hyponatremia was defined as serum sodium of

Endocrinopathy can occur as a postoperative sequel in children treated for supratentorial tumors (STTs). We assessed prediction of a residual hypothalamic/pituitary insufficiency (HPI) in these patients and factors associated with prolonged length of hospital stay (LOS). This is a retrospective cohort study of children who had surgery for STTs in two tertiary centers in Saudi Arabia (2009–2019). We assessed PICU postoperative management and risk of HPI. Data were analyzed using SPSS V24.0 and a logistic regression model for a prediction of a prolonged LOS. Data included 55 children (1–18 years, mean 9.5 ± 4.9 years) who required STT surgeries, 32 (54%) females. Craniopharyngioma (27.3%) was the commonest STTs and 20% of patients had initial symptoms of HPI. PICU management included the use of different types of intravenous fluids (IVFs) and medications such as steroids and desmopressin (DDAVP). An early postoperative DI was reported in 21.8% (n=12/55). Residual HPI included 24 (43.6%) presumed cortisol deficient and 18 (32.7%) central DI patients. Risk factors for postoperative HPI were female gender, age <6 years, headache and preoperative pituitary symptoms. LOS (Median=25.5 ± 12.2 days) was significantly prolonged in patients who required two or more doses of DDAVP [B=13; 95% CI= (1.7–24.3) days] and reduced in patients who had suspected preoperative HPI [B=−19.6; 95% CI= (−31.1, −8.2) days]. Prediction of postoperative HPI in pediatric STTs enhances an early initiation of treatment in PICU and reduces LOS. A meticulous use of IVF and medications supervised by a multidisciplinary team is essential for a favorable outcome. [ABSTRACT FROM AUTHOR]

Background The incidence of hyponatremia is high in supratentorial tumors. However, most studies of supratentorial tumors have included patients with sellar/suprasellar tumors. It is common knowledge that sellar tumors have higher incidence and severity of hyponatremia. Incidence of hyponatremia is not known if we exclude sellar/suprasellar tumors. Therefore, this study was designed to evaluate the incidence of hyponatremia in supratentorial tumors after excluding sellar/suprasellar tumors. Methods After institutional ethics committee approval and written informed consent, adult patients with supratentorial tumors (nonsellar/suprasellar) were recruited, and data were collected prospectively. In all patients, serum electrolytes were measured every 2 to 3 days. Hyponatremia was defined as serum sodium of <135 mEq/L. All the patients were followed up till death or discharge from the hospital. Results A total of 61 patients’ data were analyzed. There were 31 male and 30 female patients with an average age of 44 years. There were 23 meningiomas, 36 gliomas, and 2 other tumors. Forty patients (66%) developed hyponatremia during hospital stay. There were 29 mild cases (serum sodium 131–134 mEq/L), 7 were moderate (serum sodium 126–130 mEq/L), and 4 were severe (serum sodium <126 mEq/L). Three hyponatremic meningioma patients died, of which two had mild hyponatremia and one had severe hyponatremia. Duration of hospital stay was longer in hyponatremic patients. Conclusion The incidence of hyponatremia is high in supratentorial tumor patients after excluding sellar/suprasellar lesions. In the majority of patients, the disturbance is mild. Hyponatremic patients has a longer hospital stay and higher mortality. [ABSTRACT FROM AUTHOR]

PurposeThis study intends to explore the safety and effectiveness of the concept of enhanced recovery after surgery (ERAS) in the perioperative care of patients with supratentorial tumors.MethodsA total of 151 supratentorial tumor patients were enrolled in this study, and they were divided into control group (n = 75) and observation group (n = 76) according to the random number table method. Patients in the control group received routine neurosurgery care, and patients in the observation group received enhanced recovery after surgery care. The incidence of perioperative complications, postoperative hospital stays, early postoperative eating time, catheter removal time, and time to get out of bed were observed for the two groups of patients, and the quality of postoperative recovery was evaluated.ResultsThere was no statistically significant difference in the basic data of the two groups of patients, such as age, gender, lesion location, and condition (P>0.05), and they were comparable. The observation group’s postoperative eating time, catheter removal time, and time to get out of bed were significantly earlier than those of the control group. Postoperative hospital stays and hospitalization expenses were less than those of the control group. There was a statistically significant difference in postoperative hospital stay between the two groups (P

Purpose: This study intends to explore the safety and effectiveness of the concept of enhanced recovery after surgery (ERAS) in the perioperative care of patients with supratentorial tumors. Methods: A total of 151 supratentorial tumor patients were enrolled in this study, and they were divided into control group (n = 75) and observation group (n = 76) according to the random number table method. Patients in the control group received routine neurosurgery care, and patients in the observation group received enhanced recovery after surgery care. The incidence of perioperative complications, postoperative hospital stays, early postoperative eating time, catheter removal time, and time to get out of bed were observed for the two groups of patients, and the quality of postoperative recovery was evaluated. Results: There was no statistically significant difference in the basic data of the two groups of patients, such as age, gender, lesion location, and condition (P>0.05), and they were comparable. The observation group's postoperative eating time, catheter removal time, and time to get out of bed were significantly earlier than those of the control group. Postoperative hospital stays and hospitalization expenses were less than those of the control group. There was a statistically significant difference in postoperative hospital stay between the two groups (P<0.05). Conclusion: Applying the ERAS concept to implement perioperative care for patients with supratentorial tumors is safe and effective. It can not only reduce after-surgical stress and accelerate postoperative recovery, but also shorten hospital stays and reduce hospital costs. It is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Background: Acute hypertension is a common accompaniment during emergence from anesthesia especially in intracranial neurosurgical procedures and may be associated with the development of intracranial hematoma. Although various drugs have been evaluated, management of emergence hypertension in this subset of patients continues to be a challenge for anesthesiologists. Methodology: Seventy-five patients ASA (I-II) scheduled for supratentorial craniotomy under general anesthesia were randomly allocated to one of three groups at the time of dural closure: Group “dex” received dexmedetomidine infusion in a rate of 1 μg/kg/hr, Group “labetalol” received labetalol infusion in a rate of 0.5 mg/kg/hr, and Group “control” a control group where patients received saline infusion at the same rate of dexmedetomidine and labetalol. Hypertensive episodes were managed with nitroglycerin at a dose starting from 1 μg/kg/min if systolic blood pressure exceeded 25% of its preinduction value. Hemodynamic parameters as well as the number of patients, the total dose of nitroglycerin required in each group and the time to extubation were recorded. Results: Dexmedetomidine and labetalol had a significant effect in reducing SBP, MAP, DBP, HR during emergence from anesthesia, with more reduction of the SBP, MAP and DBP in the dexmedetomidine group and of the HR in the labetalol group in comparison with the other two groups. The number of patients needing nitroglycerin was 8 representing 32% of patients in dexmedetomidine group, 5 representing 20% of patients in labetalol group and 22 representing 88% of patients in control group (P value = 0.032). Time to emergence from anesthesia was comparable in the three groups. Conclusion: Both dexmedetomidine and labetalol had favorable effects on hemodynamics at time of emergence from anesthesia in comparison with control group without prolongation of the time of extubation.

Awake craniotomy merupakan suatu prosedur yang banyak digunakan pada kasus-kasus intrakranial dengan berbagai tujuan, yang memungkinkan dapat menentukan lokasi kelainan di otak yang akurat dan meminimalkan risiko cedera neurologis selama tindakan. Peran anaesthesiologist adalah untuk memberikan analgesia dan sedasi yang memadai sambil mempertahankan ventilasi dan stabilitas hemodinamik pada pasien yang sadar dan harus kooperatif selama tindakan berlangsung. Seorang wanita berusia 32 tahun dengan tumor supratentorial at region thalamus dextra et causa suspek thalamic glioma untuk dilakukan tindakan steriotaktik biopsi dengan Awake craniotomy. Pada pemeriksaan ditemukan keluhan sulit berjalan sejak 4 tahun karena sisi tubuh bagian kiri lemah, bicara cedal, mulut mencong ke kanan, kejang pada kepala dan mata sebelah kiri. Pasien dirujuk karena muntah hebat dan sakit kepala hebat 1 minggu terakhir, kesadaran komposmentis, GCS E4M6V5. Paresenerves VI kanan-kiri, parese nerves VII sinistra sentral. Pemeriksaan laboratorium, ECG dan foto thorak tidak didapatkan kelainan, sedangkan pada MSCT kepala didapat kan adanya massa berbatas tidak tegas, dinding tidak teratur dengan kalsifikasi minimal di thalamus kanan disertai edema perifokal kemungkinan suatu low grade astrocytoma dan hydrocephalus obstruksi. Tindakan biopsi steriotaktik terhadap tumor supratentorial ini dilakukan dengan tehnik anestesi awake craniotomy dengan obat dexmedetomidin, propofol dan fentanyl. Pengawasan pasien di ruang pemulihan selama 4 jam.Setelah Modified Aldrete score 9–10, pasien dipindahkan ke ruangan. Awake Craniotomy in Stereotactic Biopsy for Supratentorial Tumors at Thalamus Dextra Region et causa Suspect Thalamic Glioma Awake craniotomy is a procedure that is widely used in intracranial procedures with a variety purposes, which also allows an accurate localization of abnormalities in the brain, and to minimize the risk of neurological injury. Anaesthesiologist role is to provide adequateanalgesia and sedation while maintaining ventilation and hemodynamic stability in patients that still conscious and cooperative during the surgery. A 32years old woman with supratentorial tumor at theright thalamus with suspected thalamic glioma. Stereotactic biopsy was performed under awake craniotomy.She was sufferedwith difficulty in walking for 4 years due to weakness of the left side of the body,slurred talking, and lopsided mouth to the right, withspastic on the head and left eye. She was referred because of severe vomiting and headaches since 1 week, but still fully alert withGCS E4M6V5. She had bilateral nerve VI and central of left nerve VIIpareses. Her laboratory examinations, ECG and thoracic images were normal, whereas MSCT showeda mass with not firm verge, irregular wall with minimal calcification in the right thalamus and perifocaledema, suggested as a low grade astrocytoma and hydrocephalus obstruction. Stereotactic biopsy of supratentorial tumors was performed under awake craniotomy with dexmedetomidine, propofol and fentanyl. The patient was observed at the PACU for 4 hours, and after Modified Aldrete score reached 9–10, the patient was transferred to the ward.

Introduction: Tumor surgery within eloquent areas represents a formidable challenge and the use of electrical cortico-subcortical stimulation mapping (ESM), allows to localize sensorimotor and language areas and pathways. Our aim is to point out methodological issues of ESM and its impact on outcome at the light of a prospective analysis of a two-institution series of 159 patients with lesions involving eloquent areas with a lengthy follow up. Material and Methods: All patients operated on for lesions involving eloquent areas between May 2000 and May 2010 at the Neurosurgical Department of the Neurological and Neurosurgical Hospital 'P. Wertheimer' in Lyon (France) and at the Neurosurgical Department of the University Hospital in Catanzaro (Italy), were enrolled prospectively in our study. Results: Of 159 consecutive patients, 141 of them underwent surgical removal of the lesion with the aid of electrical cortico-subcortical stimulation mapping integrated in a setting of intraoperative localization of anatomic landmarks for eloquent areas. For the remaining 18 patients ESM was not deemed useful or feasible: 15 patients received a biopsy and 3 patients received tumor debulking under general anesthesia. For patients operated with ESM, it was possible to achieve a gross total removal of the lesion in 67,4% of cases (95 patients). One patient died in the immediate postoperative period for a pulmonary embolism. At a total mean follow-up of 62.8 months 78 patients were alive, 62 of which were recurrence free and had a KPS of 70% or more, while the other 80 patients had a mean survival time of 23.9 months, with a mean high quality survival period (KPS ≥ 70) of21.6 months. Discussion and Conclusion: Intraoperative electrical language and motor mapping, when feasible and indicated, consistently localizes eloquent cortical areas and subcortical pathways and allows to set the tumor resection boundaries according to functional limits, with a favorable impact on survival and quality of life. Integration of neurofunctional data with anatomic landmarks is nonetheless useful to expedite the surgical procedure and improve specificity and sensibility of functional mapping.

Background: Very few hospital-based or population-based studies are published in the context to the epidemiologic profile of pediatric brain tumors (PBTs) in India and Indian subcontinent. Aim: To study the demographic and histopathologic profile of PBTs according to World Health Organization 2007 classification in a single tertiary health care center in India. Materials and Methods: Data regarding age, gender, topography, and histopathology of 76 pediatric patients (0–19 years) with brain tumors operated over a period of 24 months (January-2012 to December-2013) was collected retrospectively and analyzed using EpiInfo 7. Chi-square test and test of proportions (Z-test) were used wherever necessary. Results: PBTs were more common in males (55.3%) as compared to females (44.7%) with male to female ratio of 1.23:1. Mean age was 10.69 years. Frequency of tumors was higher in childhood age group (65.8%) when compared to adolescent age group (34.2%). The most common anatomical site was cerebellum (39.5%), followed by hemispheres (22.4%). Supratentorial tumors (52.6%) were predominant than infratentorial tumors (47.4%). Astrocytomas (40.8%) and embryonal tumors (29.0%) were the most common histological types almost contributing more than 2/3rd of all tumors. Craniopharyngiomas (11.8%) and ependymomas (6.6%) were the third and fourth most common tumors, respectively. Conclusion: Astrocytomas and medulloblastomas are the most common tumors among children and adolescents in our region, which needs special attention from the neurosurgical department of our institute. Demographic and histopathologic profile of cohort in the present study do not differ substantially from that found in other hospital-based and population-based studies except for slight higher frequency of craniopharyngiomas.

Tumor supratentorial tersering pada orang dewasa adalah glioma (36%), meningioma (32.1%), dan adenoma pituitary (8.4%). Sekitar separuh dari tumor tersebut adalah ganas. Mayoritas tumor tumor tersebut (80%) adalah supratentorial. Untuk seluruh tumor primer, rata-rata usia terdeteksi adanya tumor otak adalah 57 tahun. Angka pasti insidens metastase tumor otak tidak diketahui namun diperkirakan cukup rendah. Dari sekitar 25% pasien yang meninggal karena kanker, ditemukan adanya metastase dari tumor sistem saraf pusat (SSP) pada otopsi. Ada lima sumber keganasan yang sering metastase ke otak yaitu kanker payudara, kanker kolorektal, kanker paru, dan melanoma. Enam persen dari pasien dengan komplikasi tersebut muncul dalam 1 tahun setelah terdeteksi adanya tumor primer. Lima jenis kanker tersebut yang sering menyebabkan metastase otak pada sekitar 37.000 kasus di Amerika Serikat. Jurnal Neuroanestesia Indonesia 17 Dilaporkan keberhasilan penanganan anestesi pada seorang pasien, wanita 56 tahun, dengan berat badan 65 kg. Pasien tersebut didiagnosis sebagai Space Occupaying Lession (SOL) kanan DD/Meningioma. Pasien dilakukan operasi kraniotomi untuk pengeluaran tumor. Tekanan darah saat masuk kamar operasi 176/100 mmHg, laju nadi 98 kali / menit, laju napas 20 kali / menit, suhu badan 370 C, dan GCS E4V5M6. Pasien diinduksi dengan Fentanyl 100 μg, Propofol 100 mg, fasilitas intubasi dengan Rocuronium 40 mg, Lidokain 70 mg, dan pemeliharaan dengan Sevofluran dan Oksigen serta Propofol kontinyu, dan penambahan fentanyl dan rokuronium intermiten. Infus terpasang dua jalur. Operasi berlangsung selama tujuh jam dua puluh menit. Dengan terpasang nasal kanul dan oksigen 3 liter/menit, pasien dipindahkan ke ICU. Pasien dirawat selama satu hari di ICU, kemudian dipindahkan ke ruangan. Setelah lima hari pasien dirawat di ruangan kemudian pasien dipulangkan dan rawat jalan dengan dokter bedah saraf. Anestesi untuk tumor supratentorial membutuhkan suatu pengertian mengenai patofisiologi dari penekanan tekanan intrakranial (TIK) lokal maupun secara keseluruhan; pengaturan dan pemeliharaan perfusi intraserebral; bagaimana menghindari akibat pengaruh sekunder dari sistemik terhadap otak. Persiapan perioperatif yang cermat dan terstruktur sangat penting pada penanganan anestesi untuk tumor supratentorial, yang meliputi persiapan pasien preoperasi, persiapan kelengkapan obat, alat, dan monitoring, serta perencanaan pelaksanaan anestesi sampai dengan pananganan pasca operasi. Anesthesia For Craniotomy Supratentorial Tumor The common supratentorial tumors in adults are glioma (36%), meningioma (32.1%), and adenoma pituitary (8.4%). Approximately half of these tumors are malignant. The majority of them ( 80%) are supratentorial. For the entire primary tumor, the average age when a brain tumor was detected is 57 years old. The exact number of metastatic brain tumor incidence is unknown, but it is assumed quite low. The existence of metastatic tumor of the central nervous system (SSP) is found at the autopsy of around 25% of patients who died of cancer. There are five sources of malignancy which often cause metastasis to the brain, namely breast cancer, colorectal cancer, lung cancer, and melanoma. In six percent of patients, these complications appeared within a year after the primary tumor is detected. These five cancers frequently cause the brain metastases in approximately 37.000 cases in the United States. It is reported the successful handling of anesthesia on a woman 56 years old, weighing 65 kg. This patient was diagnosed with Space Occupying Lession (SOL) right DD / Meningioma. Craniotomy surgery was performed for tumor expenditure. At the time she entered the operating room, her blood pressure was 176/100 mmHg, pulse rate beats / minute, respiratory rate 20 times / minute, body temperature of 37o C, and GCS E4V5M6. She was induced with Fentanyl 100 mg, 100 mg Propofol; intubation facilities are Rocuronium 40 mg, Lidocaine 70 mg, maintenance with Inhalan Sevoflurane and Oxygen, along with continuous Propofol, the addition of Fentanyl and intermittent Rocuronium. Infusion was attached in two pathways.The surgery lasted seven hours and twenty minutes. With nasal cannula and oxygen 3 liters / minute attached, the patient was transferred to ICU. She was treated for one day in ICU, before moved into a ward. After stay in the ward for five days, she was discharged and became an outpatient of neurosurgeon. Anesthesia for supratentorial tumor requires an understanding of pathophysiology of intracranial pressure (ICP) suppression locally and entirely; setting up and maintenance of intracerebral perfusion; how to avoid secondary effects of a systemic effect on the brain. Accurate and structured perioperative preparation is critical for handling of anesthesia for supratentorial tumors, which includes the preparation of the patient pre-surgery, completeness preparation of drugs, devices, and monitoring, as well as planning the implementation of the anesthesia until post-surgery tendance.

Supratentorial tumors, perioperative care, enhanced recovery after surgery, surgical treatment, safe and effective Keywords: supratentorial tumors; perioperative care; enhanced recovery after surgery; surgical treatment; safe and effective EN supratentorial tumors perioperative care enhanced recovery after surgery surgical treatment safe and effective 1 2 2 05/02/22 20220428 NES 220428 In the original article, there was a mistake in B Tables 1 b and B 2 b as published. [Extracted from the article]

Background Acute hypertension is a common accompaniment during emergence from anesthesia especially in intracranial neurosurgical procedures and may be associated with the development of intracranial hematoma. Although various drugs have been evaluated, management of emergence hypertension in this subset of patients continues to be a challenge for anesthesiologists. Methodology Seventy-five patients ASA (I-II) scheduled for supratentorial craniotomy under general anesthesia were randomly allocated to one of three groups at the time of dural closure: Group “dex” received dexmedetomidine infusion in a rate of 1 μg/kg/hr, Group “labetalol” received labetalol infusion in a rate of 0.5 mg/kg/hr, and Group “control” a control group where patients received saline infusion at the same rate of dexmedetomidine and labetalol. Hypertensive episodes were managed with nitroglycerin at a dose starting from 1 μg/kg/min if systolic blood pressure exceeded 25% of its preinduction value. Hemodynamic parameters as well as the number of patients, the total dose of nitroglycerin required in each group and the time to extubation were recorded. Results Dexmedetomidine and labetalol had a significant effect in reducing SBP, MAP, DBP, HR during emergence from anesthesia, with more reduction of the SBP, MAP and DBP in the dexmedetomidine group and of the HR in the labetalol group in comparison with the other two groups. The number of patients needing nitroglycerin was 8 representing 32% of patients in dexmedetomidine group, 5 representing 20% of patients in labetalol group and 22 representing 88% of patients in control group ( P value = 0.032). Time to emergence from anesthesia was comparable in the three groups. Conclusion Both dexmedetomidine and labetalol had favorable effects on hemodynamics at time of emergence from anesthesia in comparison with control group without prolongation of the time of extubation. [ABSTRACT FROM AUTHOR]

Purpose: Choroid plexus papillomas (CPP) are rare benign neoplasms of the central nervous system that occur most often in children during the first decade of life. They occur most often in the lateral ventricle. It is extremely rare for a CPP to occur in the pineal region. We describe the case of a child with a CPP located in the pineal region, who was initially diagnosed with obstructive hydrocephalus by cranial computed tomography (CT). Methods: A 9-year-old female patient presented with complaints of visual disturbance, nausea, and vomiting. Magnetic resonance imaging (MRI) showed a poor contrast-enhanced pineal-localized lesion. Anatomical variations within the patient caused her surgery to proceed using a supratentorial-occipital interhemispheric approach. Results: The tumor was totally removed, and a histological examination revealed the tumor to be a typical CPP. The patient received follow-up neurological and ophthalmologic examinations at 3, 6, 9, 12, 24, and 36 months postoperatively, which demonstrated her progressive improvement. Conclusions: CPPs may have a wide range of locations and resulting symptoms. However, the pineal region is a rarely encountered location, particularly for pediatric patients. It is of great value to correctly differentiate neoplasms such as germ cell tumors, pineocytomas, meningiomas, and astrocytomas, so that patients receive the correct diagnosis and treatment approach. [ABSTRACT FROM AUTHOR]

Abstract: Objective: To evaluate the role of intraoperative neurophysiological monitoring in image-guided mini-invasive neurosurgery. Methods: Twenty-one patients were operated under general anaesthesia with the aid of multimodal intraoperative neurophysiological monitoring to remove supratentorials tumors closely related to the cortico-spinal tract. Pre-operative assessment included fMRI scans and tractography that were uploaded into the intraoperative neuro-navigation system. Monitoring consisted in simultaneously recording EEG, electrocorticography, transcranial and direct motor evoked potentials (tMEP and dMEP), somatosensory evoked potentials and subcortical stimulation during the whole procedures. Results: The recording of all the electrophysiological signals was possible in all procedures. SSEP guided the positioning of the strip electrode over the motor cortex (N20 phase inversion) that was used to evoke dMEP and monitor the lower limb motor responses; subcortical stimulation to unveil the spatial relationship between the tumors and motor fibers. Four patients had transient worsening of the symptoms, but only two had a long-term worsening, although not severe, of the pre-op clinical status. Conclusions: Intraoperative neurophysiology has a great value in mini-invasive neurosurgery, especially because the motor cortex is not exposed, consequently it cannot be directly mapped. This report describes a valuable scheme making use of as many electrophysiological signals as possible to constantly monitor the motor functions. Significance: A useful method to monitor motor functions in mini-invasive neurosurgery was described. [Copyright &y& Elsevier]

Desmoplastic infantile ganglioglioma is a rare superficial supratentorial tumor that occurs within the first two years of life. Despite the worrisome radiological and histological appearance, the tumors are often curable following gross total resection. Tumors with similar characteristics are exceedingly rare in the noninfantile population. We present a six-year-old boy with seizures, weakness, and unsteady gait. Radiographic imaging confirmed a very large, solid and cystic mass in the right temporal-parietal region. Pathological examination demonstrated a tumor with severe desmoplasia identical to those reported as ‘desmoplastic infantile ganglioglioma.’ This case adds to the limited data available for desmoplastic gangliogliomas in the noninfantile population. It is not clear, yet likely, that the noninfantile form of this neoplasm is biologically similar to the infantile form. It is also unclear whether the desmoplastic noninfantile ganglioglioma has characteristics similar to classical ganglioglioma. This rare case highlights the remarkable versatility of glioneuronal tumors in children. [ABSTRACT FROM AUTHOR]