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Objective: The emergence of new human and environmental‐related toxicity data associated with some common UV filters has catalysed growing interest in the inclusion of boosters and stabilizing ingredients in sunscreens. One approach is to incorporate alternative materials inspired by or mimetic of systems in biology, which offer a notable evolutionary advantage of multifunctionality and stability with increased biocompatibility. We describe the use of a natural product, Xanthochrome® (INCI: Ammonium Xanthommatin), in a series of studies designed to not only assess its safety with marine systems but also its formulation compatibility and function in water‐in‐oil mineral sunscreens. Xanthochrome is the synthetic form of the naturally occurring chromophore xanthommatin (XA) present in cephalopod skin, which doubles as a photostable antioxidant; however, it has never been explored in combination with mineral UV filters in finished formulations. Methods: Given the recent controversies associated with the environmental toxicological effects of some chemicals used in sunscreens, the safety of XA with coral cuttings was first validated at concentrations 5× above those used in our formulations. Next, a particle‐based delivery of XA was designed and incorporated into a zinc oxide (ZnO)‐based water‐in‐oil sunscreen, where the SPF, critical wavelength, and visible light (VL) blocking potential were measured. Results: We observed no adverse effects of XA at 100 mg/L when tested with coral cuttings, demonstrating its safety at concentrations exceeding those used in our sunscreens. When formulated with ZnO‐based sunscreens, the inclusion of XA increased the total UV absorbance profile by 28% and the total blocking potential of VL by 45%. The formulations also elicited no dermal irritation or sensitization in a human insult repeat patch test (N = 100 subjects). Conclusions: XA is differentiated as a photostable, water‐soluble compound that is a VL booster proven safe for skin and coral cuttings. To the best of our knowledge, there are no other boosters that can be classified as such, despite a growing body of literature highlighting the need in the industry. [ABSTRACT FROM AUTHOR]

Overexposure to ultraviolet radiation mainly leads to skin disorders (erythema, burns, immunosuppression), skin aging, and skin cancer as the most serious side effect. It has been widely accepted that using sunscreen products is an important way to protect against the harmful effects of UV rays. Although commercial sunscreens have constantly changed and improved over time, there are emerging concerns about the safety of conventional, organic, UV filters due to adverse effects on humans (such as photoallergic dermatitis, contact sensitivity, endocrine-disrupting effects, etc.) as well as accumulation in the environment and aquatic organisms. This is why natural compounds are increasingly being investigated and used in cosmetic and pharmaceutical sunscreens. Some of these compounds are widely available, non-toxic, safer for use, and have considerable UV protective properties and less side effects. Plant-based compounds such as flavonoids can absorb UVA and UVB rays and possess antioxidant, anticarcinogenic, and anti-inflammatory effects that contribute to photoprotection. Apart from flavonoids, other natural products such as certain vegetable oils, carotenoids, stilbenes, and ferulic acid also have UV-absorbing properties. Some vitamins might also be beneficial for skin protection due to their antioxidant activity. Therefore, the aim of this research was to gain insight into the potential of natural compounds to replace or reduce the amount of conventional UV filters, based on recent research. [ABSTRACT FROM AUTHOR]

This study introduces a novel, robust, and efficient method for the simultaneous quantitative determination of three sunscreen filters, namely, 4-methylbenzylidene camphor, octyl methoxycinnamate, and avobenzone, in a moisturizing sunscreen cream specifically designed for acne-prone skin. The method employs high-performance liquid chromatography with photodiode-array detection, providing a reliable separation of the analytes. Chromatographic separation was achieved using a Fortis Phenyl analytical column (150.0 × 2.1 mm, 5 μm), with isocratic elution at a flow rate of 0.4 mL/min. The mobile phase was composed of a 57/43 (v/v) mixture of acetonitrile/45 mM aqueous ammonium formate solution, ensuring sufficient resolution and peak symmetry for the target compounds. The method was validated comprehensively for critical performance parameters, including linearity, precision, accuracy, and robustness. Linearity was established across a suitable range for all three analytes, with high correlation coefficients. Precision was confirmed with intra-run and total precision coefficients of variation of ≤4.6%, while accuracy assessments yielded a percent recovery between 98.6 and 100.4, for all quality control levels. Additionally, the method was able to effectively separate the sunscreen filters from other cosmetic ingredients, such as [β-(1.3), (1.6)-D-glucan], low molecular weight (LMW) hyaluronic acid and plant extracts ensuring specificity in complex formulations. This straightforward and time efficient sample preparation process, involving methanol extraction followed by serial dilution, makes the method suitable for routine quality control in cosmetic laboratories. The method was successfully applied to the analysis of two different lots of a commercial sunscreen cream, achieving excellent recovery for all filters, ranging between 94.6% and 99.8%, thus demonstrating its reliability and applicability for the quality control of cosmetics. [ABSTRACT FROM AUTHOR]

The earth thermal conditions increase exposure to sunlight, triggering skin damage. The skin has defense mechanisms but needs additional protection to prevent photoaging. Using sunscreen is an effort to reduce the harmful effects of sun exposure. Natural ingredients with antioxidant activity can be developed into sunscreen and antiaging products, including cloves. This study aims to assess the antioxidant, sun protection, and anti-aging properties of essential oils derived from clove leaves and buds. The antioxidant activity was assessed by the DPPH system and then formulated into 5 and 10 % clove leaves cream, as well as 5 and 10 % clove bud cream. The SPF values were assessed using a spectrophotometer and the Mansur formula. The antiaging potential was assessed using the in silico method with MMP-1 protein employing the Auto Dock Vina software, followed by analysis and visualization using BIOVIA Discovery Studio. The essential oils from clove leaves and buds have DPPH IC50 values of 23.09 and 30.31 ppm. The SPF values of clove leaves essential oil, 5 % leaves cream, and 10 % leaves cream are 38.61, 14.32, and 22.15. Meanwhile, the SPF values of clove bud essential oil, 5 % bud cream, and 10 % bud cream are 38.19, 9.32, and 18.16. The in silico test revealed that caryophyllene, eugenol, humulene, and phenol, 2-methoxy-4-(2-propenyl), acetate) have strong interactions because they can interact with the active site of proteins using hydrogen, hydrophobic, and van der Waals bonds. The essential oils from clove leaves and buds exhibit very strong antioxidant activity and offer ultra-protection as a sunscreen. The cream formulations still exhibit sunscreen activity, albeit at a lower level compared to pure essential oil. Caryophyllene, eugenol, humulene, and phenol, 2-methoxy-4-(2-propenyl)-, acetate), have potential as antiaging agents, as indicated by their binding affinity and chemical bond interactions observed in the in silico test. [ABSTRACT FROM AUTHOR]

Monitoring personal ultraviolet (UV) exposure facilitates risk mitigation against UV‐induced skin aging and skin cancer, the most common malignancy in North America, Europe, and Australia. UV radiometers convey real‐time information on local UV irradiance, while UV dosimeters count accumulated UV exposure over time. These devices can help users manage exposure levels in order to reach a healthy daily dose of UV light required for vitamin D production without exceeding erythemal limits that would increase skin cancer risk. However, personal UV detectors still suffer from several limitations. Wearable electronic UV sensors are relatively bulky, heavy, and expensive, while the more commonly used on‐skin disposable colorimetric UV sensors suffer from short service life, skin discomfort, and high accumulated costs when used daily as recommended. Intradermal colorimetric UV nanosensors can overcome these limitations, offering long‐term, comfortable, and inexpensive naked‐eye colorimetric indication of intradermal UV irradiance. Now, a new generation of UV‐sensing intradermal pigments with an improved design offers better tunability, stability, and biocompatibility. These UV‐photochromic nanosensors may be operated as UV dosimeters or simple sunscreen efficacy monitors, depending on the formulation, and can remain functional and re‐usable in the dermis for years. [ABSTRACT FROM AUTHOR]

Abstract Background Little is known about sun‐exposure and sun‐protection behaviors among tattooed individuals. Objectives This study sought to investigate the sun‐exposure and sun‐protective habits among tattooed individuals. Methods Population‐based study using a representative sample of the general population aged ≥18 years from four countries (Brazil, China, Russia and United‐States). All participants were asked to fill in a digital structured questionnaire. We inquired about socio‐demographics, self‐evaluation of their skin phototype (from I to VI), tattoo(s) and sun‐exposure and sun‐protection habits. Results A total of 9031 adult participants responded to the questionnaire of whom 1682 (18.6%) had ≥ 1 tattoo(s). The prevalence of tattoos was significantly higher among individuals with lighter skin tone (phototype I to III, 20.2%) compared to those with darker one (phototype IV to VI, 13.9%, p

Background and Aim: Evidence suggests a beneficial effect of sun exposure on type 2 diabetes mellitus (DM). However, little is known about the characteristics of sun exposure among DM patients or individuals at risk of developing DM. The aim of this study was to analyze the sun exposure behaviors of individuals diagnosed with DM and those susceptible to developing DM within a semi-urban community in North India. Materials and Methods: A population-based cross-sectional study was conducted in northern India with 494 participants aged 25–60, with or without DM. The participants’ sun exposure characteristics were assessed through a sunlight exposure questionnaire, and total sun exposure in a day was computed using the veritable sun exposure (VSE) index. Fasting blood sugar, anthropometric measurements, and demographic details were also collected. Results: The study had 56.5% female participants, and 9.1% of the participants had DM. The VSE of the study participants ranged from 0.01 to 0.81, with a mean of 0.15 (±0.14) and a median of 0.10, indicating that more than half of the study samples had less than 10% h/day of sunlight exposure. The use of sunscreen, gender, and disease status all influenced VSE. Our data suggest that the characteristics of sun exposure among Indians significantly deviate from standard recommendations. Conclusion: Our results propose a need for evidence-based guidelines and policies that promote awareness about sun exposure among DM patients as well as those at risk of developing DM. Nevertheless, these findings need to be validated through large-scale observational studies.

Sunscreens may affect thermoregulation and sweating during exercise in warm climates. In this study, we compared the effects of three sunscreens on local sweating rate (LSR) during exercise under controlled conditions (32°C, relative humidity 55%). Fifteen subjects (8 men, 7 women) underwent 20-min cycles in four randomized conditions: control (CON), sunscreen A (SSA), sunscreen B (SSB) and sunscreen C (SSC). LSR was measured by a patch on the scapular region (p < .001). CON showed higher LSR (182.21 μL/min·dm2, CI95% 168 to 195 μL/min·dm2) compared to SSA (142.10 μL/min·dm2, CI95% 128 to 155 μL/min·dm2), SSB (158.06 μL/min·dm2, CI95% 144 to 171 μL/min·dm2), and SSC (159.00 μL/min·dm2, CI95% 145 to 172 μL/min·dm2). In men, SSA showed lower LSR compared to CON, SSB, and SSC (p < .05). On the other hand, no statistically significant differences were found in LSR between SSB, SSC, and CON conditions. In women, CON was superior to all sunscreens in LSR (p < .001), and there was no difference between them (SSA, SSB, SSC, p > .05). Sunscreen reduced LSR during moderate exercise in a hot and moderate humidity environment compared to CON, especially SSA in men and all sunscreens in women. [ABSTRACT FROM AUTHOR]

Ozone serves as a potent oxidizing agent and a universal antiseptic, extensively employed in industries such as food, pharmaceuticals, and cosmetics due to its ability to dissolve in water and decompose into oxygen. This study aimed to treat virgin olive oil (VOO) with the ozonation process prior to its incorporation into a sunscreen product, and to discover any new potentially useful properties by comparing it with a sunscreen containing non-ozonated olive oil. The comparison was based on physicochemical properties, physical appearance, and sun protection factor (SPF) value. VOO treated with 0.017 mole/L ozone was tested for various physicochemical properties such as color, viscosity, refractive index, acid value, iodine value, peroxide value, saponification value, and oxidative stability. The composition was analyzed using gas chromatography (GC) and gas chromatography – mass spectrometry (GC-MS). The properties of ozonated olive oil (OOO) differed from VOO in terms of viscosity and flow behavior. An increase in shear rate significantly reduced the viscosity of OOO, while VOO maintained a constant viscosity and exhibited Newtonian flow behavior. When OOO was incorporated into sunscreen products, it enhanced the spreadability of the product on the skin, resulting in a significantly higher SPF value. The ability of a sunscreen to spread evenly on the skin and form a continuous thin film is crucial for effective protection against the sun’s rays. These findings highlight the potential of OOO in enhancing the photoprotection efficacy of sunscreen products by providing valuable data for its incorporation into formulations aiming to improve sun protection. Future research could focus on long-term stability and potential side effects of OOO in cosmetic formulations. [ABSTRACT FROM AUTHOR]

Skin cancer is the most common of all cancers worldwide. This way, it is mandatory to adopt an adequate sun protection routine, including sunscreen lotions. However, despite the proven effectiveness of numerous chemical filters, many of them are also known for their allergenic and carcinogenic potential effects, which can be mitigated by exploring some encapsulation routes. Thus, the present work evaluates the influence of seven distinct ultraviolet (UV) organic filters on the final particle size and molecular weight distributions of poly(methyl methacrylate) (PMMA) beads. Moreover, the sun protection factors (SPF) of the loaded nanoparticles are also evaluated when used for preparation of sunscreen formulations. The UV filters did not affect the course of MMA miniemulsion polymerizations significantly, enabling the synthesis of loaded nanoparticles. Nevertheless, adding the filters shifted the particle size distributions toward larger diameters, which are appropriate for cosmetic formulations. Based on the SPF analyses, it was also possible to observe a 12‐fold increase in the SPF values of the prepared formulations and an increase in the critical wavelength. Therefore, the in situ incorporation of distinct UV filters during miniemulsion MMA polymerizations constitutes a robust and versatile technology to produce PMMA nanoparticles loaded with UV filters for preparation of sunscreen formulations. [ABSTRACT FROM AUTHOR]

Liquid crystal (LC) emulsion is a new emulsion system which has excellent application potential in the field of cosmetics. In this study, the LC emulsifier and traditional emulsifier were used to prepare the emulsions containing different types of sunscreen agents, respectively. The microstructure, sunscreen performance and rheological properties of the emulsions were studied systematically. The results showed that the formation of LC structure was not affected by sunscreen agents. LC structure can also enhance the sunscreen property of the emulsion as well as improve the sensory property. Further, we combined different sunscreen agents to prepare LC sunscreen emulsion. The sunscreen performance and repair effectiveness of emulsion were evaluated by human test. The results showed that LC sunscreen emulsion has an increased SPF value from 56 to 70 compared to non-LC sunscreen emulsion. Meanwhile, the LC structure also enhanced the moisturising properties of the emulsion, and the TEWL value of LC emulsion and non-LC emulsion was 67.4% and 96.5%, respectively. In addition, LC sunscreen emulsion has higher safety and better storage stability. In conclusion, this study provided the practical application of LC emulsion systems as well as the important guidance for developing excellent sunscreen emulsions. [ABSTRACT FROM AUTHOR]

Traditional sunscreens, especially organic ultraviolet (UV) absorbers such as benzophenone, have strong photoactivity and skin permeability, which may cause some human injuries and even cancer. Therefore, it is of great practical significance to develop efficient and safe new sunscreen. With anhydrous zinc acetate (Zn(Ac)2), titanium tetrachloride (TiCl4) and dopamine hydrochloride as raw materials and ethanol/water solution as solvent, polydopamine (PDA) coated Zn-Ti layered double hydroxide (P@ZTL) compounded particles were synthesized through a hydrothermal method. Afterwards, sunscreen samples were prepared with them as the only UV-blocking component. The chemical structure, composition and micro- morphology, along withUV absorbance, free radical scavenging and cytotoxicity performance of P@ZTL were studied. Indispensably, the UV-blocking properties of the sunscreen samples were tested. The results showed that the structure of P@ZTL was 1~5 μm PDA coated ZTL compounded particles, with a specific surface area of 145. 916 m2/g. The particles had a typical mesoporous structure with a porosity of 0. 154 cm3/g. The compounded particles had great UV absorption and reactive oxygen species(ROS)scavenging abilities, along with no cytotoxicity. The sunscreen with P@ZTL had excellent UV protecting performance, which could preserve fibroblasts from direct UV irradiation. The sun protection index(SPF)values of sunscreen samples added with 10% and 15% P@ZTL reached 47. 3±2. 3 and 75. 1±3. 1, respectively, which could fully meet the daily use. Therefore, the synthesized P@ZTL sunscreen has a great application prospect in cosmetics. [ABSTRACT FROM AUTHOR]

Background: Dark‐skinned individuals (DSI) present high rates of melasma and post‐inflammatory hyperpigmentation. The use of sunscreens with mineral filters is essential for prevention and treatment. Our objective was to determine the preferences of dermatologists and dermatology residents in the prescription of sunscreens for DSI. Methods: An anonymous survey of attendees at an online photoprotection event held on March 31, 2022, in Spain. Results: The survey was answered by 66.6% (221/332) of the attendees: 159 dermatologists (71.9%) and 62 dermatology residents (28.1%). Respondents reported recommending the use of sunscreen to a median of 80% of DSI [interquartile range (IQR), 50–90]. Physicians reported prescribing tinted sunscreens to a median percentage of 60% (IQR, 25–90) of DSI with acne; and to a median percentage of 90% (IQR, 58–99) of DSI with melasma. The most prescribed photoprotectors to DSI with melasma were organic broad‐spectrum sunscreens with antioxidants: 102/220 (46.4%) and mineral broad‐spectrum sunscreens (with iron oxides): 45/220 (20.4%). In DSI with melasma or other pigmentary disorders, the most preferred features of sunscreens were as follows: sun protection factor ≥ 30: 217/221 (98.2%), UVA protection: 214/221 (96.8%), color for camouflage: 150/220 (68.2%) and mineral filters such as titanium dioxide and zinc oxide: 151/220 (68.6%) or iron oxides: 131/220 (59.5%). Limitations: Online survey, potential inclusion bias. Conclusions: Respondents reported to prescribe sunscreens to the majority of DSI, and tinted sunscreens for the majority of DSI with pigmentary disorders. However, the most frequently recommended sunscreens for DSI were organic broad‐spectrum sunscreens with antioxidants. [ABSTRACT FROM AUTHOR]

Background: Tinted sunscreens not only shield against UV rays but also provide protection against visible light, as opposed to traditional sunscreens. Universal tinted sunscreens are marketed to complement all skin tones. Objective: To assess color match and subject satisfaction for 7 universal tinted sunscreens across various price ranges in all Fitzpatrick skin phototypes (SPT). Methods: Products A‐G were applied at concentrations of 1 and 2 mg/cm2 on the dorsal arms of 30 subjects spanning SPT I–VI. Photography, colorimetry, and subject and investigator surveys were utilized to determine color match. Results: Using colorimetry analysis at the recommended 2 mg/cm2 concentration, two of seven products were identified as suitable matches for SPT I–II, while six out of seven were determined to be a good match for SPT III–IV. However, only one product was found to be a good match for SPT V–VI at the recommended concentration according to colorimetry results. Conclusion: Universal tinted sunscreens do not provide an adequate color match for all skin phototypes, especially for individuals with very fair or very dark skin tones. [ABSTRACT FROM AUTHOR]

Lopezia racemosa is known as a "mosquito flower or perlilla." It is commonly found in corn crops. In traditional Mexican medicine, this plant is used to treat stomach cancer and urinary tract infections. Likewise, compounds and extracts isolated from plants have shown cytotoxic and anti‐inflammatory effects. The objective of this study was to evaluate the photochemoprotective effect of topical treatment with the methanolic extract of L. racemosa (MELR) as a photochemoprotective agent against the harmful effects of UV irradiation (UVR) on a bacterial model and hairless mice. The MELR components were separated and analyzed via HPLC‐UV‐ESI‐MS. Antioxidant activity was evaluated by the ability of MERL to scavenge DPPH and ABTS free radicals and by its FRAP capacity. The toxicity of MELR was evaluated in keratinocyte cultures. The photoprotective capacity of MELR was assessed through challenge experiments using models with bacteria and hairless CD1 et/et mice; cytokines related to the damage caused by UVR were also measured. In the methanolic extract of L. racemosa, five metabolites were detected and identified: two isomers of quercetin 6‐C glycoside, orientin, quercetin 3‐(6″‐acetylglycoside) and quercetin 3‐(6″‐galloylglycoside) 7‐(2,3‐dihydroxytetrahydro‐2H‐pyran‐4‐yl acetate). MELR exhibited DPPH and ABTS radical scavenging properties, in addition to Fe ion reducing activity. MELR showed a photoprotective effect against UVB radiation‐induced death in Escherichia coli bacteria. At the histological level, topical treatment of CD‐1 et/et mice with MERL reduced the damage caused by UVR. Quantification of interleukins in the blood of mice revealed that the expression of IL‐12 was greater in the control group treated with ultraviolet radiation than in the group protected with MELR. The methanolic extract of L. racemosa has photochemoprotective properties. [ABSTRACT FROM AUTHOR]

Background and Aims: Skin cancer is a significant public health concern globally. Jordan’s location and high exposure to UV radiation have led to an increase in the incidence rate of skin cancer. This study aimed to investigate the knowledge, attitudes, and practices of patients to sunscreen use in one of the major hospitals in Jordan, and identify demographic factors associated with regular sunscreen use. Methodology: An observational cross-sectional study was conducted at the dermatology clinic of Jordan University Hospital, Amman, Jordan, from February 2, 2023 to March 6, 2023. The study included 397 participants recruited from the clinic’s waiting area. A validated survey questionnaire was used to collect data on demographics, previous skin cancer history, sunscreen allergies, knowledge, attitudes, and practices related to sunscreen use. The data were analyzed using SPSS v. 26. Statistical significance was established at a p-value of <0.05. Results: The majority of participants were female (67.0%) and aged 18–25 years (53.7%). Only 24.9% of participants reported using sunscreen regularly, while 34.0% reported never using it. Participants with higher education levels and income were more likely to use sunscreen regularly. The main sources of sunscreen recommendations were family and friends (48.1%), followed by dermatologists (32.7%). The most common reason for not using sunscreen was forgetfulness (40.1%). Conclusion: The study revealed that knowledge and practices related to sunscreen use among Jordanian dermatology patients are insufficient, and that there is a need for increased patient education regarding the importance of sunscreen use. [ABSTRACT FROM AUTHOR]

This article presents the findings of a survey conducted at an outdoor football game to understand sun protection behaviors and barriers among spectators. The survey had a response rate of 90.6% and included questions on demographics, sun protection habits, barriers to use, and history of skin examination. The results showed that older individuals used more sun protection methods compared to younger individuals, and women were more likely to use sunscreen and get skin checks by a dermatologist. The overall rate of sunscreen use was high, but participants aged 18-23 and men were less likely to use sun protection. The article suggests targeted interventions to promote sun safety, increase skin health literacy among college-aged students, and encourage more men to adopt sun-protective practices. [Extracted from the article]

The increasing use of UV filters, such as benzophenone-3 (BP-3) and titanium dioxide nanoparticles (TiO2 NPs), has raised concerns regarding their ecotoxicological effects on the aquatic environment. The aim of the present study was to examine the embryo-larval toxicity attributed to BP-3 or TiO2 NPs, either alone or in a mixture, utilizing zebrafish (Danio rerio) as a model after exposure to environmentally relevant concentrations of these compounds. Zebrafish embryos were exposed to BP-3 (10, 100, or 1000 ng/L) or TiO2 NPs (1000 ng/L) alone or in a mixture (BP-3 10, 100, or 1000 ng/L plus 1000 ng/L of TiO2 NPs) under static conditions for 144 hr. After exposure, BP-3 levels were determined by high-performance liquid chromatography (HPLC). BP-3 levels increased in the presence of TiO2 NPs, indicating that the BP-3 degradation decreased in the presence of the NPs. In addition, in the presence of zebrafish, BP-3 levels in water decreased, indicating that zebrafish embryos and larvae might absorb BP-3. Data demonstrated that, in general, environmentally relevant concentrations of BP-3 and TiO2 NPs, either alone or in a mixture, did not significantly induce changes in heart and spontaneous contractions frequencies, levels of reactive oxygen species (ROS), morphological and morphometric parameters as well as mortality rates during 144 hr exposure. However, the groups exposed to TiO2 NPs alone and in a mixture with BP-3 at 10 ng/L exhibited an earlier significant hatching rate than the controls. Altogether, the data indicates that a potential ecotoxicological impact on the aquatic environment exists. [ABSTRACT FROM AUTHOR]

Based on laser confocal Raman spectroscopy technology, a real-time in vivo testing method for the depth distribution and transdermal penetration of sunscreen in the stratum corneum of the skin was established using a skin component analyzer combined with multivariate linear regression analysis. Using volunteers' arms as the experimental subject, the consistency of transdermal penetration ability of three common sunscreen agents, OMC, DBHB, and EHT, was tested and analyzed in different skin regions of the arm. And the transdermal penetration of the sunscreen agents in sunscreen lotions with different formulation was compared. The results indicate that the relative standard deviation of the skin penetration of sunscreen in different areas on the inner side of the arm is less than 15%, indicating that the method is suitable for comparison of the skin penetration of different sunscreen products. After one hour of skin penetration, it is found that the transdermal penetration of the three sunscreen agents in the skin is reduced by about 60%, and the penetration depth of EHT is relatively shallow, when the in oil-in-water sunscreen compared to the nano emulsion sunscreen. This method has been effectively applied in the study of transdermal penetration of sunscreen agents, and can provide methodological references for transdermal absorption of cosmetics. [ABSTRACT FROM AUTHOR]

Objective The objective of this study was to assess the prevalence and characteristics of, and knowledge about, photosensitivity and the use of photoprotective measures in an international cohort of cutaneous lupus erythematosus and SLE patients. Methods We conducted an international, cross-sectional study based on a 46-question web-based survey, including patients with medically confirmed lupus erythematosus, conducted between November 2021 and April 2022. Results A total of 600 patients with lupus erythematosus [94% female, median age: 41 years, interquartile range (IQR): 33–51] from 50 countries were included. A history of photosensitivity was reported by 389/600 (64.8%) patients. Photosensitivity was associated with the presence of other cutaneous involvement [odds ratio (OR) = 3.8; 95% CI 2.5–5.7; P  < 0.001] and differed according to the area of residence and level of education (P  < 0.001, for all). Photosensitivity was characterized by a wide range of clinical manifestations (both cutaneous and systemic symptoms in 56.1% and systemic symptoms only in 29.8% of patients). Fatigue was the most frequently reported systemic manifestation (82.3%). Overall, 559/600 (93%) patients were aware of the detrimental role of ultraviolet radiation exposure in lupus erythematosus, but 160/480 (33.3%) were unaware of the importance of photoprotective measures, including 90/310 (29%) among those with photosensitivity. Conclusion A high rate of self-reported photosensitivity characterizes lupus erythematosus patients. Photosensitivity frequently includes subjective features, which makes it difficult to evaluate in clinical practice. As fatigue is frequent in lupus erythematosus, further study is needed to clarify the causal link with ultraviolet radiation exposure. About one-third of lupus erythematosus patients are unaware of the importance of photoprotective measures. This should be improved through more frequent and targeted awareness interventions. [ABSTRACT FROM AUTHOR]

Dyschromia is a top diagnosis among African Americans (AA). Sunscreen is an essential part of its management, but AA have low sunscreen use. We sought to examine the perception of sunscreen utility in dyschromia and photoaging among patients who identify as AA or Black. This cross-sectional study recruited participants from the Case Western Reserve University Academic Dental Clinic. Participants completed an electronic survey that contained questions related to sunscreen use, knowledge of the sun’s role in hyperpigmentation and photoaging, and whether sunscreen could be used for hyperpigmentation and photoaging. Of the 151 participants recruited, 63.6% (n = 96) were women and 36.4% (n = 57) were men. Consistent with previous reports, participants had lower sunscreen use (20.5%) than whites (43.5%). The majority of participants (80.1% and 58.3%, respectively) didn’t attribute the sun to hyperpigmentation or photoaging. Participants with dark/brown spots were significantly more likely to not attribute the sun to hyperpigmentation than those without spots. (p = 0.003) Limitations for this study include its small sample size, recall and reporter bias, question misinterpretation, and lack of question neutrality. This study highlights the knowledge gap of a major contributing factor to dyschromia which in turn could be leading to their view of the decreased utility of sunscreen. [ABSTRACT FROM AUTHOR]

Importance: One in five Americans will develop skin cancer during their lifetime. While use of sunscreen can help prevent the development cutaneous cancer, regular use remains low nationwide. Objective: To assess and better understand health care consumer preferences for sun protection products and perceived product accessibility and availability based on socioeconomic factors, race, and ethnicity. Design: This quantitative survey study was conducted March through June of 2023. Setting: Participants were recruited from two university family medicine clinical sites in the Buffalo, New York area, one located in a low and one located in a middle-to-upper socioeconomic neighborhood. Participants: Eligible participants were 18 years or older, fluent in English, and residents of the Buffalo, New York area. Surveys and consent forms were distributed by scripted verbal invitation, inviting all clinic patients who met eligibility criteria to participate. Participants were asked to self-report their racial/ethnic group as well as other demographic information including age, gender identification, household income, and household size. Information regarding sun exposure behaviors, and affordability/access was obtained using a combination of multiple choice and yes/no questions. A total of 405 participants were recruited. After excluding 235 incomplete responses, 170 surveys were available for analysis. Interventions: None. Main outcomes and measures: Our study aim was to expose health care consumer preferences as well as barriers to access based on socioeconomic factors, race, and ethnicity. Results: Using a 25-question anonymous survey, 405 participants from two university family medicine clinical sites representing low- and middle-to-high-income neighborhoods, participated in the survey. 170 participants completed the survey questions and were included for analysis. Of those, 61.8% identified as female, 37.6% as male, and 0.6% as other. 51.2% of participants identified as lower income, 38.2% as middle-income, and 10.6% as upper income. The results of the survey revealed disparities in sunscreen use and affordability perceptions across demographic groups. Compared with Hispanics, Caucasians exhibited higher rates of sunscreen use (85 Caucasians, 7 Hispanics; p = 0.0073), prioritized SPF (95 Caucasians, 10 Hispanics; p = 0.0178), and were more likely to perceive sunscreen as unaffordable (6 Caucasians, 4 Hispanics; p = 0.0269). Analysis by Fitzpatrick Skin Type demonstrated differences in sunscreen utilization, with Types I-III using more compared to Types IV-VI (70 Types I-III, 51 Types IV-VI; p = 0.0173); additionally, Type I-III individuals were significantly more likely to cite cost as barrier to sunscreen purchase (40 Type I-III, 65 Types IV-VI; p < 0.0001). Moreover, lower-income individuals were significantly more likely to perceive sunscreen as unaffordable (12 lower-income, 1 middle & upper income; p = 0.0025) and cited cost as a barrier to purchase (46 lower-income, 59 middle & upper income; p = 0.0146) compared to middle-to-upper income counterparts. Though statistical significance was not established, respondents from middle & upper income groups reported higher sunscreen usage rates compared with their lower-income peers. Conclusions and relevance: These findings highlight the importance of socioeconomic factors and ethnicity on accessibility to sunscreen and the impact of disparities in utilization among different ethnic and socioeconomic groups. [ABSTRACT FROM AUTHOR]

Background: Skincare and makeup "pilling" is an unsightly and undesirable phenomenon whereby skincare such as moisturizers or foundation ball up to form flakes on the skin. To date, the causes of skincare product pilling have not been studied. This study aimed to examine the relationship between skin physiology and pilling potential of sunscreen and foundation (the two products most reported by consumers to cause pilling). This study also examined the effects of product application methods on pilling. Materials and methods: 528 female volunteers from Guangzhou, China, aged between 20 and 49 years, underwent various clinical skin assessments, followed by three steps of product layering. Pilling was assessed after each product application step. Results: 217 volunteers (41%) experienced pilling. The majority of pilling (n = 655 events) occurred following sunscreen application, while only a few pilling events (n = 35) occurred with foundation. Foundation improved pilling caused by sunscreen in 98.9% of cases. Volunteers experiencing pilling with both sunscreen and foundation had significantly lower facial skin hydration and oiliness, higher pH, and smoother skin texture (P < 0.05). Two application methods, rubbing of products in circular and linear motions, yielded the highest numbers of pilling events. Conclusion: This study has provided the first insights into the causes of pilling. Sunscreen is a promoter of pilling, while foundation may resolve sunscreen‐induced pilling in many cases. Skin physiology, particularly drier, smoother skin with higher pH, and product application methods are likely contributing factors to this undesirable phenomenon. [ABSTRACT FROM AUTHOR]

Natural compounds are becoming increasingly popular in the fields of pharmaceuticals and cosmetics. One such compound is lignin, a plant-derived aromatic polymer that serves as a natural anti-ultraviolet agent. Conventional methods for extracting lignin from plant materials typically involve performing procedures in harsh environments, such as dissolving it in highly alkaline solutions or subjecting it to treatment in acidic conditions. In this study, lignin was extracted from coconut husk under milder conditions, using neutral solvents and ultrasonic treatment, which allowed us to obtain lignin with significantly improved properties. The developed method facilitated the creation of light-colored lignin, which was employed as a natural ingredient in sunblock cream. Furthermore, for the sake of comparison, lignin was extracted under more rigorous conditions using the traditional method. The research findings confirm that the light-colored lignin sample exhibits a higher level of UV absorption. Furthermore, light-colored lignin demonstrates a synergistic effect when combined with commercial moisturizing creams and sunscreens, leading to a significant enhancement in their SPF performance against both UVA and direct sunlight exposure. This study highlights the potential value of incorporating lignin as a valuable natural ingredient in sunblock and cosmetic products. [ABSTRACT FROM AUTHOR]

Tamarind (Tamarindus indica L.) rind is one of the natural products which has been proven to have antioxidant and sunscreen activities. It has the potential to be developed into cosmetic product such as cream. This study aims to determine the correlation between the antioxidant activity and the Sun Protection Factor (SPF) of tamarind rind ethanol extract cream. Tamarind rind was macerated in ethanol (96%) for 5 days, the extract was concentrated over a water bath to obtain a dried tamarind rind ethanol extract. The tamarind rind ethanol extract was formulated into creams using three different concentrations of tamarind rind ethanol extract as the active ingredient; FI (5%), F2 (10%), and F3 (15%). The sunscreen protection activity of the creams was assessed by determining the sun protection factor (SPF) using the Mansur formula. The antioxidant activity of the creams was evaluated by the DPPH (2,2-Diphenyl-1-picrylhydrazyl) radical scavenging assay. The correlation between the IC50 value of the antioxidant activity and the SPF value was analyzed using the Spearman's rank correlation test. Results show that formulation F3 has the highest sunscreen activity with SPF value of 6.469, but all the formulation has very weak antioxidant activity (IC50 < 200 ppm). The Spearman's rank correlation analysis showed a significant relationship between the IC50 value and the SPF value of tamarind rind ethanol extract cream, which suggests that the higher the antioxidant activity, the higher the SPF value of the cream formulation. [ABSTRACT FROM AUTHOR]

Sun exposure induces major skin alterations, but its effects on skin metabolites and lipids remain largely unknown. Using an original reconstructed human epidermis (RHE) model colonized with human microbiota and supplemented with human sebum, we previously showed that a single dose of simulated solar radiation (SSR) significantly impacted the skin metabolome and microbiota. In this article, we further analyzed SSR‐induced changes on skin metabolites and lipids in the same RHE model. Among the significantly altered metabolites (log2‐fold changes with p ≤ 0.05), we found several natural moisturizing factors (NMFs): amino acids, lactate, glycerol, urocanic acid, pyrrolidone carboxylic acid and derivatives. Analyses of the stratum corneum lipids also showed that SSR induced lower levels of free fatty acids and higher levels of ceramides, cholesterols and its derivatives. An imbalance in NMFs and ceramides combined to an increase of proinflammatory lipids may participate in skin permeability barrier impairment, dehydration and inflammatory reaction to the sun. Our skin model also allowed the evaluation of an innovative ultraviolet/blue light (UV/BL) broad‐spectrum sunscreen with a high sun protection factor (SPF50+). We found that using this sunscreen prior to SSR exposure could in part prevent SSR‐induced alterations in NMFs and lipids in the skin ecosystem RHE model. [ABSTRACT FROM AUTHOR]

The application of mineral sunscreens is an effective and safe way to protect skin from damage by UV rays. However, many options on the market are not formulated with darker skin tones in mind, so they end up looking chalky. Tinted Pickering emulsions synthesized from polydopamine (PDA), a biologically friendly melanin-like particle, have the potential to resolve these issues and provide better protection for conditions such as hyperpigmentation and melisma. In this study, a series of amorphous SiO2–PDA nanoparticles with fumed silica as the nucleus scaffold and PDA coating as the adhesive layer were synthesized by a simple one-pot method. Compared to the pure spherical PDA nanoparticles without a scaffold, SiO2–PDA has a higher particle yield, lighter color, better dispersion performance, and superior emulsification ability. When further applied to the Pickering emulsion sunscreen, the chromaticity of the emulsions can be flexibly adjusted and effectively improved by the addition of titanium dioxide (TiO2) nanoparticles. Additionally, SiO2–PDA stabilized emulsion exhibits high UV absorption, photothermal effect, high free radical scavenging, and low skin penetration, which is a potential candidate by combining biocompatibility, long-term stability, and high safety in tinted sunscreens as well as other biomedical applications. [ABSTRACT FROM AUTHOR]

Temu mango (Curcuma manga Val) is a rhizome plant native to Indonesia that contains curcuminoid and flavonoid antioxidant compounds. These compounds are believed to act as UV-light protectors, especially UV B. In this study, we performed a qualitative test of the compound content in temu mango followed by formulation and activity testing of water in oil (w/o) sunscreen lotion of temu mango in vitro. The optimization of the w/o lotion formulation was performed using Design Expert® (DE) software version 9.0.4.1 with the Simplex Lattice Design method. The DE software obtained 13 runs of the w/o lotion formula and continued testing the physical property to determine the optimum formula. The optimum formula of lotion w/o predicted by DE software was tested for physical stability for over 4 weeks; and the SPF test, percent pigmentation, and percent erythema were determined by UV-Vis spectrophotometry. The present results suggested that temu mango extract provided an SPF value at a concentration of 0.3 mg/mL with an SPF value of 16.62. The optimum formula of the lotion w/o were 7% glycerin, 7% cera alba, 5% cetyl alcohol with a value of stickiness of 0.70 ± 0.03 s, spreadability of 13.20 ± 0.83 cm², and viscosity of 95.19 ± 3.06 dPa.s. Referring to the storage results, the optimum formula of w/o lotion from temu mango extract was stable during a month of storage. The w/o lotion in the optimum formula produced an SPF value of 15.06 ± 0.39, % erythema of 10.95%, and percent pigmentation of 10.41%. [ABSTRACT FROM AUTHOR]

Participation in outdoor sports increases exposure to ultraviolet radiation, necessitating mitigation through sunscreen use. This prospective study examined the effects of sport, setting (practice vs. competition), gender, age and geographic location on sunscreen use and education among youth athletes in various sports. Six hundred and twelve athletes ≤18 years old completed an online survey on sunscreen education and use during competitions and practices. Regardless of sport, reported sunscreen use was higher during practices than competition (p < 0.0001). Sunscreen was used most by swimmers/divers (odds ratio: OR ≥ 1.9, p < 0.001) and least by American football players (OR ≤ 0.57, p ≤ 0.001). Coaches mentioned sunscreen use the most in track and field (OR 1.84, p = 0.001) and the least in American football (OR 0.67, p = 0.03). Athletes used sunscreen more if they were female (OR ≥ 1.9 1.38, p ≤ 0.06) and younger (age OR ≤ 0.88, p < 0.001). In conclusion, youth athletes differ in sunscreen use by sport and setting, highlighting the need for continued photoprotective education. [ABSTRACT FROM AUTHOR]

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Background and Aim: Evidence suggests a beneficial effect of sun exposure on type 2 diabetes mellitus (DM). However, little is known about the characteristics of sun exposure among DM patients or individuals at risk of developing DM. The aim of this study was to analyze the sun exposure behaviors of individuals diagnosed with DM and those susceptible to developing DM within a semi-urban community in North India. Materials and Methods: A population-based cross-sectional study was conducted in northern India with 494 participants aged 25-60, with or without DM. The participants' sun exposure characteristics were assessed through a sunlight exposure questionnaire, and total sun exposure in a day was computed using the veritable sun exposure (VSE) index. Fasting blood sugar, anthropometric measurements, and demographic details were also collected. Results: The study had 56.5% female participants, and 9.1% of the participants had DM. The VSE of the study participants ranged from 0.01 to 0.81, with a mean of 0.15 (±0.14) and a median of 0.10, indicating that more than half of the study samples had less than 10% h/day of sunlight exposure. The use of sunscreen, gender, and disease status all influenced VSE. Our data suggest that the characteristics of sun exposure among Indians significantly deviate from standard recommendations. Conclusion: Our results propose a need for evidence-based guidelines and policies that promote awareness about sun exposure among DM patients as well as those at risk of developing DM. Nevertheless, these findings need to be validated through large-scale observational studies. [ABSTRACT FROM AUTHOR]

Abstract: The risks associated with climate events are the main factors responsible for sweet orange production losses in Brazil. For rainfed citrus cultivation, it is mainly due to soil water deficit, but also to citrus cultivation associated with extreme temperatures. The present study investigated the effects of water management in ‘Pera’ sweet orange orchards under sub-humid climate conditions and application of calcium carbonate-based sunscreen on the plant canopy, aiming to mitigate the effects of abiotic stresses on orchard physiology, production, and irrigation water use efficiency. The experimental design was in randomized blocks in a 3 x 2 factorial scheme. Treatments for water management factor were: full irrigation (100% ETc), irrigation with moderate deficit (65% ETc), and no irrigation; and for sunscreen protection: sunscreen use and no sunscreen. The factors have impacted gas exchange, fruit quality, and orchard yield. There was no isolated effect of soil water management on orchard productivity, but with sunscreen, citrus plants are more resilient based on gas exchange data, mitigating environmental effects (high temperatures and water deficit), resulting in improvements in fruit quality related to total fruit mass in plants grown without irrigation and with 12% increase in orchard productivity, regardless of soil water management. Productivity gains related to sunscreen indicate the need for the use of sunscreen protection regardless of soil water management in the region.

Heterotrigona itama stingless bee propolis extract is known for its diverse bioactive compounds, making it a potential natural shield against UV radiation. This research assesses the photoprotective potential of crude ethanol extract from H. itama propolis collected from four structures (involucrum, pillar, pot, and entrance) of five bee hives (H1-H5), totalling 20 samples. Initially, the samples underwent testing for SPF value and UV absorption spectra. The crude ethanol extract (E) from the involucrum (H4) with the highest SPF value and broadest spectrum was selected for fractionation using hexane and water. Subsequently, the extract (E) and its hexane (H) and water (W) fractions were subjected to SPF analysis, UVA/UVB absorption assessment, determination of total phenolic and flavonoid content, free radical scavenging capacity, anti-collagenase effects, and cytotoxicity assessment. Additionally, LC-MS/MS analysis was performed to identify chemical constituents in the active fraction (W). The extract E demonstrated an SPF of 8.23 ± 0.09 and UV absorption. Notably, its fraction W exhibited the highest SPF (16.55 ± 0.24) at 100 μg/mL, surpassing the H fraction (SPF 5.7 ± 0.45). Phenolic content was highest in the H fraction (388.95 ± 4.54 mg/g GAE DW), followed by the W fraction (286.76 ± 6.48 mg/g GAE DW) and crude E (91.83 ± 4.12 mg/g GAE DW) from the involucrum. Regarding flavonoids, the fraction W led with 79.82 ± 6.21 mg/g QE DW, followed by the H fraction (45.56 ± 0.05 mg/g QE DW) and E (34.57 ± 1.11 mg/g QE DW). The extract E also exhibited modest DPPH scavenging (EC50 = 120 μg/mL), while the H fraction demonstrated stronger activity (EC50 = 4.37 μg/mL), and the W fraction displayed moderate effects (EC50 = 17.55 μg/mL). Notably, the W fraction showed remarkable anti-collagenase activity, outperforming the positive control, EG. HaCaT cell cytotoxicity revealed that the extract E was cytotoxic, whereas the H and W fractions showed no toxicity. LC-MS/MS analysis identified bioactive flavonoids (e.g., pratensein, quercetin) in the W fraction. These findings highlight the superior photoprotective properties of the water fraction from the involucrum of H. itama stingless bee propolis extract, suggesting its potential as a natural and effective ingredient for sunscreen and skincare formulations.

This article discusses a rare case of allergic contact dermatitis caused by bis-ethylhexyloxyphenol methoxyphenyl triazine, also known as Tinosorb S, which is a commonly used UV filter in sunscreens. The case involves a 37-year-old woman who experienced a rash and itching after applying two different sunscreens containing Tinosorb S. Patch tests confirmed a positive reaction to the ingredient provided by one manufacturer, highlighting the importance of verifying hapten concentrations. The article suggests that bis-ethylhexyloxyphenol methoxyphenyl triazine may become an emerging allergen in sunscreens due to its increasing use by cosmetics manufacturers. [Extracted from the article]

Abstract Background Despite extensive research on sun protection, there remains a gap in certain populations like Lebanon. It is essential to assess how Lebanese adults handle sun exposure and its risks. Objectives To examine the knowledge and habits of sun protection use among adults in Lebanon and explore the possible association between a history of skin cancer or photo‐related disorder and sun protection behaviours. Methods We conducted a single‐centre cross‐sectional study on 1001 patients presenting to the American University of Beirut Medical Center dermatology clinics from August 2020 till April 2023. Participants were between 18 and 80 years of age and recruited by convenience sampling. Those younger than 18 years old or not proficient in English or Arabic were excluded. Results Among 1001 adults (mean age, 36.06 years [SD, 14.72]; 708 [71.08%] female), 512 (52.78%) use sunscreen, 449 (46.29%) do not and 9 (0.93%) do not know. Respondents with a history of a photo‐related condition (melasma, lentigos/freckles and rosacea) were significantly more likely to be sunscreen users (p

Excessive UV exposure can cause various skin disorders, so protection from UV rays is needed by using sunscreen. One of the plants that have the potential as a sunscreen is buas-buas leaf (Premna serratifolia Linn.) which contains flavonoid compounds. Sunscreen formulated in lotion form is the most common preparation found in the market. The purpose of this study was to evaluate the physical characteristics of lotion preparations and to determine the potential of lotion of buas-buas leaf extract as a sunscreen. Buas-buas leaf extract was obtained through maceration extraction with 96% ethanol solvent. Lotion with the active substance of buas-buas leaf extract was made with concentration variations of 1, 2, and 3%. Evaluation of the physical characteristics of the lotion was tested with organoleptic observation parameters, homogeneity, pH, spreadability, and adhesion. Then, it was tested for sunscreen potential using UV-Vis spectrophotometry. Data were analyzed with SPSS Statistics 22 software, namely the One Way ANOVA (Analysis of Variance) test. The results of the study were the three lotion formulas of buas-buas leaf extract met all the requirements of the physical characteristics evaluation test. The SPF value of F1 (1%) is 7.12 (extra protection), F2 (2%) is 9.54 (maximum protection) and F3 (3%) is 15.68 (ultra protection). Based on the results of the study, it can be concluded that the lotion of buas-buas leaf extract meets the requirements of evaluating the physical characteristics of lotions and has activity as a sunscreen.

Grape marc is a by-product resulting from the winemaking industry that still contains beneficial compounds that can be valorized. Thus, we report here the possibility of using polyphenolic extracts of grape marc origin to obtain sun protection creams. The extractions were performed in ethanol and acetone solutions using pomace from different grape varieties (Merlot, Bläufrankisch, Fetească Neagră, Isabella) as a raw material. The obtained extracts were analyzed in order to determine the total phenolic content, the antioxidant activity, and the sun protection factor (SPF) via Mansur spectrophotometric assay. The best results were achieved using 70% ethanol in water as a solvent. The extracts with the highest potential photoprotective effects are from the Merlot variety (SPFspectrophotometric = 7.83 ± 0.76). The sunscreens were prepared using the 70% ethanolic extract of the Merlot variety evaporated to dryness, redissolved in either distilled water or ethanol. The SPF estimated in vitro via the COLIPA method showed values of 14.07 ± 1.50 and 11.46 ± 1.32 for the aqueous and ethanolic extracts, respectively, when working with a cream to polyphenolic extract a ratio of 1/1 (w/w). At the same time, the use of aqueous polyphenolic extracts ensures the better stability of creams compared with the ethanolic ones. [ABSTRACT FROM AUTHOR]

In order to improve CeO 2 ultraviolet absorption performance and transparency, this paper puts forward that different proportions of calcium oxide are doped during the formation of CeO 2. Doping calcium ions with larger ion size and lower valence leads to the formation of oxygen defects by inhibiting the precipitation of oxygen from cerium oxide and keeps the fluorite structure of cerium oxide stable. The effects of CaO doping on the crystal structure, morphology, and optical characteristics of CeO 2 were analyzed by XRD, SEM, TEM, TGA, XPS, UV–vis spectrophotometry. The pH of sunscreen, spread ability and some physical as well as chemical evaluations were carried out, while to study its UV protection performance the sunscreen SPF test was performed. The UV–vis results revealed that CeO 2 /20%CaO showed highly efficient UV absorption capacity. After adding calcium oxide, the catalytic activity of the material is reduced, due to which the generation of free radicals is demoted, and the harm to human body is decreased. After the addition of 3 wt% nanomaterials into sunscreen, the sun protection factor（SPF ）values of pure cerium oxide and CeO 2 /20%CaO are 1.95 and 2.81, and their sun protection coefficient is increased by 69.39%. Therefore, it is an ideal candidate as a component of ultraviolet screening agent in sunscreens and provides a new idea for the research direction of cerium oxide in anti-ultraviolet applications. [ABSTRACT FROM AUTHOR]

Chamazulene (CA) is an intensely blue molecule with a wealth of biological properties. In cosmetics, chamazulene is exploited as a natural coloring and soothing agent. CA is unstable and tends to spontaneously degrade, accelerated by light. We studied the photodegradation of CA upon controlled exposure to UVB-UVA irradiation by multiple techniques, including GC-MS, UHPLC-PDA-ESI-MS/MS and by direct infusion in ESI-MSn, which were matched to in silico mass spectral simulations to identify degradation products. Seven byproducts formed upon UVA exposure for 3 h at 70 mW/cm2 (blue-to-green color change) were identified, including CA dimers and CA benzenoid, which were not found on extended 6 h irradiation (green-to-yellow fading). Photostability tests with reduced irradiance conducted in various solvents in the presence/absence of air indicated highest degradation in acetonitrile in the presence of oxygen, suggesting a photo-oxidative mechanism. Testing in the presence of antioxidants (tocopherol, ascorbyl palmitate, hydroxytyrosol, bakuchiol, γ-terpinene, TEMPO and their combinations) indicated the highest protection by tocopherol and TEMPO. Sunscreens ethylhexyl methoxycinnamate and particularly Tinosorb® S (but not octocrylene) showed good CA photoprotection. Thermal stability tests indicated no degradation of CA in acetonitrile at 50 °C in the dark for 50 days; however, accelerated degradation occurred in the presence of ascorbyl palmitate. [ABSTRACT FROM AUTHOR]

The emerging pollutant octocrylene is not efficiently removed from effluents by conventional treatment and is recurrently found in rivers. This study evaluated the adsorption of octocrylene using commercial carbon and biochar from spent coffee grounds activated with ZnCl2. The two adsorbents had an efficiency of approximately 100% in pollutant removal throughout the experimental design. The kinetics and equilibrium isotherms showed a good correlation with the experimental data. The kinetics showed adsorption of the contaminant in 40 min for both adsorbents. The model equilibrium isotherms with the best fit and adsorption capacity was Langmuir for biochar, with a capacity of 37.822 ± 0.005 µg∙mg−1 compared to 33.602 ± 0.202 µg∙mg−1 for commercial carbon. Furthermore, a toxicity analysis of a 600 µg∙L−1 octocrylene solution was carried out before and after adsorption with the two charcoals separately, using Allium cepa roots. Before adsorption, the solution was phytotoxic and cytogenotoxic. After adsorption, the solution obtained for each charcoal no longer caused toxicity to the roots. The charcoals tested had high removal efficiency and adsorption capacity, a condition reiterated by the toxicity results. However, biochar better represented the Langmuir model in the adsorption process when removing octocrylene from the aqueous medium. [ABSTRACT FROM AUTHOR]

The aim of this study of sun protection factor boosting effect sunscreen compositions with herbal extract and combination with octocrylene. The standardized herbal extracts procured and studied their sun protection Factors. Camellia Sinensis (Green tea) leaf Extract, Eclipta prostrata (bhringraj) leaf extract are selected for the development of the herbal sunscreen composition along with octocrylene as synthetic sunscreen. The developed sunscreen composition contains defined concentration of herbal extracts and octocrylene were evaluated for their different physicochemical properties and stability. Sun protection factor boosting effect of herbal extracts is studied combination with octocrylene. Invitro SPF studied for herbal extract individually and combination with octocrylene. The results of Invitro SPF study revealed the presence of green tea extract and, Eclipta prostrata (bhringraj) leaf extract shows excellent sun protection factor (SPF) boosting value of sunscreen composition containing 5% concentration of herbal extract and octocrylene. The sunscreen formulation containing 5% herbal extracts are stable for 12 weeks in an oven (45 °C). The findings of this in-vitro SPF study revealed a sun protection boosting capacity of green tea extract and bhringraj extract confirmed. The over exposure of human skin to Ultra-Violet Radiation (UVR) can trigger photodamage, UV burn, pigmentation, erythema, and enhance the chance of dermal carcinoma. UVR causes DNA damage, which leads to dermal cancer. Daily sunscreens protect the skin from the adverse effects of sun rays, especially UVB (290-320 nm) and UVA (320-400 nm). The ozone layer filters UVC (200-290 nm) radiation when it enters into atmosphere of the earth. UVB causes sunburn, photo damage and cause mutagenic changes in nucleic acids. UVA increases ROS (Reactive Oxygen Species) accumulation. ROS is responsible for cell repair which leads to carcinogenesis, and the cause of photodamage. Herbal extracts contain polyphenols, and flavonoids act as a natural sunscreen that will filter Ultra-Violet (UVB) light and contain antioxidant characteristics to modulate the photo-oxidative damage that results from UV-induced Reactive Oxygen Species production. The UVR protection of most herbal extracts are required to attain the higher UV protection in the sun care products. The approaches for preparing sun care products with higher Sun Protection Factor (SPF) possible through Oil in water formulation with herbal extract combinations of octocrylene. The developed sunscreen composition containing different concentration of herbal extracts were evaluated for their other physicochemical properties and stability. Invitro SPF was studied for Camellia Sinensis (Green tea) Leaf Extract and Eclipta prostrata (bhringraj) leaf extract individually and in combination with octocrylene. The results of the Invitro SPF study revealed the Camellia Sinensis (Green tea) Leaf Extract with octocrylene shows better Sun protection factor than Eclipta prostrata (bhringraj) leaf extract with octocrylene. The Sun Protection Factor (SPF) enhancement value of sunscreen compositions was compared to both sunscreen macroemulsion and nanoemulsion. [ABSTRACT FROM AUTHOR]

Sunscreens are essential in protecting the skin from harmful effects of ultraviolet radiation (UVR). These formulations, designed to absorb, block, or scatter UVR, offer vital protection against skin aging, sunburns, and the development of skin cancers like melanomas. However, some sunscreens, especially those containing organic/chemical compounds, can cause allergic reactions. To address this, researchers are extensively investigating formulations that incorporate plant extracts rich in polyphenols, such as flavonoids and carotenoids, which can be considered safer alternatives. Products derived from plants are commonly used in cosmetics to counteract skin aging due to their antioxidant activity that combat harmful free radicals. This review focuses on evaluating the advancements in chemical and natural sunscreens, exploring the integration of polyphenolic nanocarriers within sunscreen formulas, their interaction with UVR, and utilizing nanotechnology to enhance their effectiveness. An attempt has been made to highlight the concerns related to toxicity associated with their use and notable advancements in the regulatory aspects governing their utilization. [ABSTRACT FROM AUTHOR]