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8 results on '"Summers, Alyssa R."'

3. Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

Author

Bhaskara, Srividya, Knutson, Sarah K., Jiang, Guochun, Chandrasekharan, Mahesh B., Wilson, Andrew J., Zheng, Siyuan, Yenamandra, Ashwini, Locke, Kimberly, Yuan, Jia-ling, Bonine-Summers, Alyssa R., Wells, Christina E., Kaiser, Jonathan F., Washington, M. Kay, Zhao, Zhongming, Wagner, Florence F., Sun, Zu-Wen, Xia, Fen, Holson, Edward B., Khabele, Dineo, and Hiebert, Scott W.

Published
2010
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4. HDAC3 is essential for DNA replication in hematopoietic progenitor cells

Author

Summers, Alyssa R., Fischer, Melissa A., Stengel, Kristy R., Zhao, Yue, Kaiser, Jonathan F., Wells, Christina E., Hunt, Aubrey, Bhaskara, Srividya, Luzwick, Jessica W., Sampathi, Shilpa, Chen, Xi, Thompson, Mary Ann, Cortez, David, and Hiebert, Scott W.

Subjects
Gene expression -- Physiological aspects -- Analysis -- Health aspects, DNA replication -- Physiological aspects -- Analysis, Leukemia -- Genetic aspects -- Care and treatment, Lymphomas -- Genetic aspects -- Care and treatment, Genetic engineering -- Health aspects, Health care industry
Abstract

Histone deacetylase 3 (HDAC3) contributes to the regulation of gene expression, chromatin structure, and genomic stability. Because HDAC3 associates with oncoproteins that drive leukemia and lymphoma, we engineered a conditional [...]

Published
2013
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8. Transforming Growth Factor-β and Cancer.

Author

Teicher, Beverly A., Caligiuri, Michael A., Lotze, Michael T., Bonine-Summers, Alyssa R., Law, Brian K., and Moses, Harold L.

Abstract

Normal tissue homeostasis is maintained by strict regulation of interactions between cells and their microenvironment. How a cell responds to stimulatory and inhibitory signals it receives from the microenvironment will directly impact whether or not that particular cell will proceed through the cell cycle and proliferate or stop cell cycle progression and undergo assessment. When cells no longer respond to their microenvironmental cues and proliferate autonomously, tumors arise. The major known negative regulators of cell proliferation are the transforming growth factor βs (TGF-βs). The TGF-β signaling pathways are tumor suppressive, yet once tumors have developed, TGF-β signaling can enhance tumor progression. [ABSTRACT FROM AUTHOR]

Published
2007
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