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HDAC3 is essential for DNA replication in hematopoietic progenitor cells

Authors :
Summers, Alyssa R.
Fischer, Melissa A.
Stengel, Kristy R.
Zhao, Yue
Kaiser, Jonathan F.
Wells, Christina E.
Hunt, Aubrey
Bhaskara, Srividya
Luzwick, Jessica W.
Sampathi, Shilpa
Chen, Xi
Thompson, Mary Ann
Cortez, David
Hiebert, Scott W.
Source :
Journal of Clinical Investigation. July 1, 2013, Vol. 123 Issue 7, p3112, 12 p.
Publication Year :
2013

Abstract

Histone deacetylase 3 (HDAC3) contributes to the regulation of gene expression, chromatin structure, and genomic stability. Because HDAC3 associates with oncoproteins that drive leukemia and lymphoma, we engineered a conditional [...]

Subjects

Subjects :
Gene expression -- Physiological aspects -- Analysis -- Health aspects
DNA replication -- Physiological aspects -- Analysis
Leukemia -- Genetic aspects -- Care and treatment
Lymphomas -- Genetic aspects -- Care and treatment
Genetic engineering -- Health aspects
Health care industry

Details

Language :
English
ISSN :
00219738
Volume :
123
Issue :
7
Database :
Gale General OneFile
Journal :
Journal of Clinical Investigation
Publication Type :
Academic Journal
Accession number :
edsgcl.341937500
Full Text :
https://doi.org/10.1172/JCI60806
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