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1. Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia.

Author

Asker C, Mareni C, Coviello D, Ingvarsson S, Sessarego M, Origone P, Klein G, and Sumeigi J

Subjects
Acute Disease, Humans, Karyotyping, Male, Middle Aged, Base Sequence, Gene Amplification, Leukemia genetics, Proto-Oncogenes, Sequence Homology, Nucleic Acid
Abstract

Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10-15 fold amplified c-myc sequences. The linked pvt-1-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.

Published
1988
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