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16 results on '"Suhara, Wakako"'

9. X-ray crystal structure of IRF-3 and its functional implications

Author

Takahasi, Kiyohiro, primary, Suzuki, Nobuo N, additional, Horiuchi, Masataka, additional, Mori, Mitsuaki, additional, Suhara, Wakako, additional, Okabe, Yasutaka, additional, Fukuhara, Yukiko, additional, Terasawa, Hiroaki, additional, Akira, Shizuo, additional, Fujita, Takashi, additional, and Inagaki, Fuyuhiko, additional

Published
2003
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12. X-ray crystal structure of IRF-3 and its functional implications.

Author

Takahasi, Kiyohiro, Suzuki, Nobuo N, Horiuchi, Masataka, Mori, Mitsuaki, Suhara, Wakako, Okabe, Yasutaka, Fukuhara, Yukiko, Terasawa, Hiroaki, Akira, Shizuo, Fujita, Takashi, and Inagaki, Fuyuhiko

Subjects
X-rays, CRYSTALS, INTERFERONS, PHOSPHORYLATION, CHEMICAL reactions
Abstract

Transcription factor IRF-3 is post-translationally activated by Toll-like receptor (TLR) signaling and has critical roles in the regulation of innate immunity. Here we present the X-ray crystal structure of the C-terminal regulatory domain of IRF-3(175-427) (IRF-3 175C) at a resolution of 2.3 Å. IRF-3 175C is structurally similar to the Mad homology domain 2 of the Smad family. Structural and functional analyses reveal phosphorylation-induced IRF-3 dimerization, which generates an extensive acidic pocket responsible for binding with p300/CBP. Although TLR and Smad signaling are evolutionarily independent, our results suggest that IRF-3 originates from Smad and acquires its function downstream of TLR. [ABSTRACT FROM AUTHOR]

Published
2003
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16. Control of IRF-3 activation by phosphorylation.

Author

Yoneyama M, Suhara W, and Fujita T

Subjects
Animals, DNA-Binding Proteins chemistry, DNA-Binding Proteins genetics, Dimerization, Forecasting, Humans, Interferon Regulatory Factor-3, Nuclear Proteins chemistry, Nuclear Proteins metabolism, Phosphorylation, Protein Processing, Post-Translational, Protein Serine-Threonine Kinases metabolism, RNA, Double-Stranded pharmacology, Signal Transduction, Trans-Activators chemistry, Trans-Activators metabolism, Transcription Factors chemistry, Transcription Factors genetics, Transcriptional Activation, Virus Diseases metabolism, DNA-Binding Proteins metabolism, Transcription Factors metabolism
Abstract

Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by posttranslational modifications. We review current knowledge of the mechanism of IRF-3 activation: signalling triggered by infections including viruses and bacteria, phosphorylation of IRF-3 on certain serine residues, homodimer formation, and active holocomplex formation with coactivator CBP/p300.

Published
2002
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