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Control of IRF-3 activation by phosphorylation.
- Source :
-
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2002 Jan; Vol. 22 (1), pp. 73-6. - Publication Year :
- 2002
-
Abstract
- Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by posttranslational modifications. We review current knowledge of the mechanism of IRF-3 activation: signalling triggered by infections including viruses and bacteria, phosphorylation of IRF-3 on certain serine residues, homodimer formation, and active holocomplex formation with coactivator CBP/p300.
- Subjects :
- Animals
DNA-Binding Proteins chemistry
DNA-Binding Proteins genetics
Dimerization
Forecasting
Humans
Interferon Regulatory Factor-3
Nuclear Proteins chemistry
Nuclear Proteins metabolism
Phosphorylation
Protein Processing, Post-Translational
Protein Serine-Threonine Kinases metabolism
RNA, Double-Stranded pharmacology
Signal Transduction
Trans-Activators chemistry
Trans-Activators metabolism
Transcription Factors chemistry
Transcription Factors genetics
Transcriptional Activation
Virus Diseases metabolism
DNA-Binding Proteins metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1079-9907
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
- Publication Type :
- Academic Journal
- Accession number :
- 11846977
- Full Text :
- https://doi.org/10.1089/107999002753452674