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2. Occupations and the Risk of Head and Neck Cancer: A Pooled Analysis of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Author

Khetan, P. Boffetta, P. Luce, D. Stucker, I. Curado, M.P. Menezes, A. Wunsch-Filho, V. Ahrens, W. Lagiou, P. Serraino, D. Richiardi, L. Kjaerheim, K. Conway, D. Thomson, P. Muscat, J. Mates, D. Ramroth, H. Menvielle, G. Vaughan, T.L. Brenner, H. Lee, Y.-C.A. La Vecchia, C. Hashibe, M. Hashim, D.

Abstract

Objective:To investigate the associations between head and neck cancer (HNC) risk and occupations.Methods:We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR.1Results:Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC.Conclusions:We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship. Copyright © 2019 American College of Occupational and Environmental Medicine.

Published
2019

3. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years

Author

Taioli, E, Gaspari, L, Benhamou, S, Boffetta, P, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, ML, Dolzan, V, Haugen, A, Hirvonen, A, Husgafvel-Pursiainen, K, Kalina, I, Kremers, P, Le Marchand, L, London, S, Rannug, A, Romkes, M, Schoket, B, Seidegard, J, Strange, RC, Stucker, I, To-Figueras, J, and Garte, S

Published
2003

4. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study

Author

Fehringer, G., Brenner, D. R., Zhang, Z. -F., Lee, Y. -C. A., Matsuo, K., Ito, H., Lan, Q., Vineis, P., Johansson, M., Overvad, K., Riboli, E., Trichopoulou, A., Sacerdote, C., Stucker, I., Boffetta, P., Brennan, P., Christiani, D. C., Hong, Y. -C., L, i, M. T., Morgenstern, H., Schwartz, A. G., Wenzlaff, A. S., Rennert, G., McLaughlin, J. R., Harris, C. C., Olivo-Marston, S., Orlow, I., Park, B. J., Zauderer, M., Barros Dios, J. M., Ruano Raviña, A., Siemiatycki, J., Koushik, A., Lazarus, P., Fernández-Somoano, A., Tardon, A., Le March, Brenner, H., Saum, K. -U., Duell, E. J., Andrew, A. S., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Holcatova, I., Pesatori, A. C., Consonni, D., Olsson, A., Straif, K., Hung, R. J., and Fehringer, G. and Brenner, D.R. and Zhang, Z.-F. and Lee, Y.-C.A. and Matsuo, K. and Ito, H. and Lan, Q. and Vineis, P. and Johansson, M. and Overvad, K. and Riboli, E. and Trichopoulou, A. and Sacerdote, C. and Stucker, I. and Boffetta, P. and Brennan, P. and Christiani, D.C. and Hong, Y.-C. and Landi, M.T. and Morgenstern, H. and Schwartz, A.G. and Wenzlaff, A.S. and Rennert, G. and McLaughlin, J.R. and Harris, C.C. and Olivo-Marston, S. and Orlow, I. and Park, B.J. and Zauderer, M. and Barros Dios, J.M. and Ruano Raviña, A. and Siemiatycki, J. and Koushik, A. and Lazarus, P. and Fernández-Somoano, A. and Tardon, A. and Le Marchand, L. and Brenner, H. and Saum, K.-U. and Duell, E.J. and Andrew, A.S. and Szeszenia-Dabrowska, N. and Lissowska, J. and Zaridze, D. and Rudnai, P. and Fabianova, E. and Mates, D. and Foretova, L. and Janout, V. and Bencko, V. and Holcatova, I. and Pesatori, A.C. and Consonni, D. and Olsson, A. and Straif, K. and Hung, R.J.

Subjects
Male, Asia, Alcohol Drinking, alcohol consumption, sex difference, cohort analysi, environmental exposure, cancer risk, high risk patient, Article, smoking, liquor, adverse effect, middle aged, controlled study, smoking, Aged, human, Alcoholic Beverage, wine, risk reduction, alcohol, adult, Risk Factor, disease association, drinking behavior, occupational exposure, case control study, lung adenocarcinoma, major clinical study, Europe, Lung Neoplasm, aged, lung cancer, female, North America, pathology, beer, small cell lung cancer, Cohort Studie, Case-Control Studie, squamous cell lung carcinoma
Abstract

It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0–4.9 g per day: OR = 0.80, 95% CI = 0.70–0.90; 5–9.9 g per day: OR = 0.82, 95% CI = 0.69–0.99; 10–19.9 g per day: OR = 0.79, 95% CI = 0.65–0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance. © 2017 UICC

Published
2017

5. Lung Cancer Among Firefighters: Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies

Author

Bigert, C, Gustavsson, P, Straif, K, Taeger, D, Pesch, B, Kendzia, B, Schuz, J, Stucker, I, Guida, F, Bruske, I, Wichmann, H E, Pesatori, A C, Landi, M T, Caporaso, N, Tse, L A, Yu, I T, Siemiatycki, J, Lavoue, J, Richiardi, L, Mirabelli, D, Simonato, L, Jockel, K H, Ahrens, W, Pohlabeln, H, Tardon, A, Zaridze, D, Field, J K, t Mannetje, A, Pearce, N, McLaughlin, J, Demers, P, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Stanescu Dumitru, R, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Peters, S, Vermeulen, R, Kromhout, H, Bruning, T, Olsson, A C, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Bigert, C., Gustavsson, P., Straif, K., Taeger, D., Pesch, B., Kendzia, B., Schüz, J., Stücker, I., Guida, F., Brüske, I., Wichmann, H.-E., Pesatori, A.C., Landi, M.T., Caporaso, N., Tse, L.A., Yu, I.T.-S., Siemiatycki, J., Lavoué, J., Richiardi, L., Mirabelli, D., Simonato, L., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Tardón, A., Zaridze, D., Field, J.K., Mannetje, A., Pearce, N., McLaughlin, J., Demers, P., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Peters, S., Vermeulen, R., Kromhout, H., Brüning, T., and Olsson, A.C.

Subjects
Gerontology, Canada, China, Lung Neoplasms, Medizin, Logistic regression, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Occupational Exposure, Odds Ratio, Medicine, Humans, 030212 general & internal medicine, Lung cancer, Cell specific, business.industry, Environmental and Occupational Health, Smoking, Public Health, Environmental and Occupational Health, Absolute risk reduction, Case-control study, Odds ratio, medicine.disease, 030210 environmental & occupational health, Europe, Occupational Diseases, Pooled analysis, Case-Control Studies, Firefighters, Lung cancer - firefighters, Public Health, Occupational exposure, business, Demography, New Zealand
Abstract

Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter. Copyright © 2016 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited.

Published
2016

6. Risk of fatal industrial accidents and death from other external causes among asphalt workers

Author

Burstyn, I., Boffetta, P., Jarvholm, B., Partanen, T., Svane, O., Langard, S., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D., Ahrens, W., Bergdahl, I., Cenee, S., Hooiveld, M., Randem, B.G., Johansen, C., Ferro, G., and Kromhout, H.

Subjects
Health
Abstract

The hypothesis that asphalt workers are at increased risk of mortality from industrial accidents and other external causes was tested. Mortality rates for external and violent causes of death in [...]

Published
2004

7. Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-associated vasculitis: follow-up data from European Vasculitis Study Group clinical trials

Author

Heijl, C., Harper, L., Flossmann, O., Stucker, I., Scott, D.G.I., Watts, R.A., Hoglund, P., Westman, K., Mahr, A., European Vasculitis Study Grp EUVA, and Faculteit Medische Wetenschappen/UMCG

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Cyclophosphamide, Immunology, Population, BLADDER-CANCER, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, THERAPY, General Biochemistry, Genetics and Molecular Biology, WEGENERS-GRANULOMATOSIS, Rheumatology, Neoplasms, Internal medicine, Azathioprine, CYCLOPHOSPHAMIDE, medicine, Humans, Multicenter Studies as Topic, Immunology and Allergy, COHORT, POLYANGIITIS, education, METAANALYSIS, Aged, Randomized Controlled Trials as Topic, RISK, education.field_of_study, Bladder cancer, business.industry, Cancer, Middle Aged, medicine.disease, RANDOMIZED-TRIAL, METHOTREXATE, Europe, Female, Skin cancer, Epidemiologic Methods, Microscopic polyangiitis, Vasculitis, Granulomatosis with polyangiitis, business, Immunosuppressive Agents, medicine.drug
Abstract

Objectives Because standard immunosuppressive treatment for antineutrophil cytoplasm antibody-associated vasculitis (AAV) (granulomatosis with polyangiitis (Wegener's) (GPA) and microscopic polyangiitis (MPA)) has been associated with a significant risk of developing cancer, the cancer incidence of treated AAV patients was assessed.Methods This analysis concerned 535 patients with newly diagnosed AAV from 15 countries who had been enrolled between 1995 and 2002 in four European clinical trials. Over the period 2004-7, study participants' follow-up events were updated, including cancers diagnosed. Age, sex and area-standardised incidence ratios (SIR) and their 95% CI were calculated by linkage to five national cancer databases.Results During the 2650 person-years' observation period, 50 cancers were diagnosed in 46 patients. SIR (95% CI) were 1.58 (1.17 to 2.08) for cancers at all sites, 1.30 (0.90 to 1.80) for cancers at all sites excluding non-melanoma skin cancer (NMSC), 2.41 (0.66 to 6.17) for bladder cancer, 3.23 (0.39 to 11.65) for leukaemia, 1.11 (0.03 to 6.19) for lymphoma and 2.78 (1.56 to 4.59) for NMSC. Subgroup SIR for cancers at all sites were 1.92 (1.31 to 2.71) for GPA and 1.20 (0.71 to 1.89) for MPA.Conclusions Cancer rates for AAV patients treated with conventional immunosuppressive therapy exceeded those expected for the general population. This cancer excess was largely driven by an increased incidence of NMSC. The smaller cancer risk magnitude in this cohort, compared with previous studies, might reflect less extensive use of cyclophosphamide in current treatment protocols. Longer follow-up data are warranted to appraise the risk of developing cancers later during the course of AAV.

Published
2011

8. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

Author

Conway, D.I. Brenner, D.R. McMahon, A.D. Macpherson, L.M.D. Agudo, A. Ahrens, W. Bosetti, C. Brenner, H. Castellsague, X. Chen, C. Curado, M.P. Curioni, O.A. Maso, L.D. Daudt, A.W. De Gois Filho, J.F. D'Souza, G. Edefonti, V. Fabianova, E. Fernandez, L. Franceschi, S. Gillison, M. Hayes, R.B. Healy, C.M. Herrero, R. Holcatova, I. Jayaprakash, V. Kelsey, K. Kjaerheim, K. Koifman, S. La Vecchia, C. Lagiou, P. Lazarus, P. Levi, F. Lissowska, J. Luce, D. Macfarlane, T.V. Mates, D. Matos, E. McClean, M. Menezes, A.M. Menvielle, G. Merletti, F. Morgenstern, H. Moysich, K. Müller, H. Muscat, J. Olshan, A.F. Purdue, M.P. Ramroth, H. Richiardi, L. Rudnai, P. Schantz, S. Schwartz, S.M. Shangina, O. Simonato, L. Smith, E. Stucker, I. Sturgis, E.M. Szeszenia-Dabrowska, N. Talamini, R. Thomson, P. Vaughan, T.L. Wei, Q. Winn, D.M. Wunsch-Filho, V. Yu, G.-P. Zhang, Z.-F. Zheng, T. Znaor, A. Boffetta, P. Chuang, S.-C. Ghodrat, M. Lee, Y.-C.A. Hashibe, M. Brennan, P.

Abstract

Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR 5 2.50; 95% CI 5 2.02-3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR 5 1.61; 95% CI 5 1.13-2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels. © 2014 UICC.

Published
2015

10. Occupational exposure to organic dust increases lung cancer risk in the general population

Author

Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.E., Bruske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jockel, K.H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J, Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stucker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Bruning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Peters, S., Kromhout, H., Olsson, A.C., Wichmann, H.-E., Brüske, I., Consonni, D., Landi, M.T., Caporaso, N., Siemiatycki, J., Richiardi, L., Mirabelli, D., Simonato, L., Gustavsson, P., Plato, N., Jöckel, K.-H., Ahrens, W., Pohlabeln, H., Boffetta, P., Brennan, P., Zaridze, D., Cassidy, A., Lissowska, J., Szeszenia-Dabrowska, N., Rudnai, P., Fabianova, E., Forastiere, F., Bencko, V., Foretova, L., Janout, V., Stücker, I., Dumitru, R.S., Benhamou, S., Bueno-de-Mesquita, B., Kendzia, B., Pesch, B., Straif, K., Brüning, T., Vermeulen, R., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Canada, Lung Neoplasms, case-control study, Population, Medizin, Cumulative Exposure, Logistic regression, Article, Toxicology, Occupational Exposure, Environmental health, Humans, Medicine, Lung cancer, education, Aged, Asthma, education.field_of_study, business.industry, Smoking, Case-control study, Public Health, Environmental and Occupational Health, Dust, Middle Aged, medicine.disease, Occupational exposure to organic du, respiratory tract diseases, Europe, Occupational Diseases, lung cancer, Quartile, Case-Control Studies, Meta-analysis, Female, business
Abstract

Background: Organic dust is a complex mixture of particulate matter from microbial, plant or animal origin. Occupations with exposure to animal products have been associated with an increased lung cancer risk, while exposure to microbial components (eg, endotoxin) has been associated with a decreased risk. To date there has not been a comprehensive evaluation of the possible association between occupational organic dust exposure (and its specific constituents) and lung cancer risk in the general population. Methods: The SYNERGY project has pooled information on lifetime working and smoking from 13 300 lung cancer cases and 16 273 controls from 11 case - control studies conducted in Europe and Canada. A newly developed general population job-exposure matrix (assigning no, low or high exposure to organic dust, endotoxin, and contact with animals or fresh animal products) was applied to determine level of exposure. ORs for lung cancer were estimated by logistic regression, adjusted for age, sex, study, cigarette pack-years, time since quitting smoking, and ever employment in occupations with established lung cancer risk. Results: Occupational organic dust exposure was associated with increased lung cancer risk. The second to the fourth quartile of cumulative exposure showed significant risk estimates ranging from 1.12 to 1.24 in a dose-dependent manner (p

Published
2012

11. Polycyclic aromatic hydrocarbons and fatal ischemic heart disease

Author

Burstyn, I., Kromhout, H., Partanen, T.J., Svane, O., Langard, S., Ahrens, W., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Boffetta, P., Faculteit Diergeneeskunde, Secretariat, U754, Unit of Environment Cancer Epidemiology, IARC, Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Department of Public Health Sciences, University of Alberta, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Central American Institute for Studies on Toxic Substances, Universidad National, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Bremen Institute for Prevention Research and Social Medicine, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Institute of Cancer Epidemiology, Danish Cancer Society, Burstyn, I., Kromhout, H., Partanen, T., Svane, O., Langård, S., Ahrens, W., Kauppinen, T., Stücker, I., Shaham, J., Heederik, D., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B.G., Boffetta, P., and Faculteit Diergeneeskunde

Subjects
Male, Epidemiology, Denmark, Myocardial Ischemia, MESH: Occupational Exposure, MESH: Cause of Death, chemistry.chemical_compound, Risk Factors, MESH: Risk Factors, Cause of Death, Germany, Determinants in Health and Disease [EBP 1], Israel, Polycyclic Aromatic Hydrocarbons, Finland, MESH: Finland, Confounding, Smoking, Absolute risk reduction, MESH: Israel, Confounding Factors, Epidemiologic, Occupational Diseases, Cohort, Benzopyrene, MESH: Myocardial Ischemia, France, MESH: Occupational Diseases, medicine.medical_specialty, MESH: Smoking, Ischemic heart disease, Coronacrisis-Taverne, Occupational medicine, MESH: Polycyclic Hydrocarbons, Aromatic, Interventional oncology [UMCN 1.5], Environmental health, Occupational Exposure, medicine, Humans, cardiovascular diseases, Risk factor, MESH: Germany, MESH: Denmark, MESH: Humans, business.industry, MESH: Confounding Factors (Epidemiology), MESH: Male, MESH: France, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Relative risk, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

Background: Several toxicologic and epidemiologic studies have produced evidence that occupational exposure to polycyclic aromatic hydrocarbons (PAH) is a risk factor for ischemic heart disease (IHD). However, a clear exposure-response relation has not been demonstrated. Methods: We studied a relation between exposure to PAH and mortality from IHD (418 cases) in a cohort of 12,367 male asphalt workers from Denmark, Finland, France, Germany, Israel, The Netherlands and Norway. The earliest follow up (country-specific) started in 1953 and the latest ended in 2000, averaging 17 years. Exposures to benzo(a)pyrene were assessed quantitatively using measurement-driven exposure models. Exposure to coal tar was assessed in a semiquantitative manner on the basis of information supplied by company representatives. We carried out sensitivity analyses to assess potential confounding by tobacco smoking. Results: Both cumulative and average exposure indices for benzo(a)pyrene were positively associated with mortality from IHD. The highest relative risk for fatal IHD was observed for average benzo(a)pyrene exposures of 273 ng/m 3 or higher, for which the relative risk was 1.64 (95% confidence interval = 1.13-2.38). Similar results were obtained for coal tar exposure. Sensitivity analysis indicated that even in a realistic scenario of confounding by smoking, we would observe approximately 20% to 40% excess risk in IHD in the highest PAH-exposure categories. Conclusions: Our results lend support to the hypothesis that occupational PAH exposure causes fatal IHD and demonstrate a consistent exposure-response relation for this association. Copyright © 2005 by Lippincott Williams & Wilkins.

Published
2005

12. Risk of fatal industrial accidents and death from other external causes among asphalt workers

Author

Burstyn, I., Boffetta, P., Jarvholm, B., Partanen, T., Svane, O., Langard, S., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D., Ahrens, W., Bergdahl, I., Cenee, S., Hooiveld, M., Randem, Bg, christoffer johansen, Ferro, G., Kromhout, H., Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Unit of Environment Cancer Epidemiology, IARC, Occupational Medicine, Department of Public Health and Clinical Medicine, Umea University Hospital, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Bremen Institute for Prevention Research and Social Medicine, Institute of Cancer Epidemiology, Danish Cancer Society, Secretariat, U754, Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Järvholm, B., Partanen, T., Svane, O., Langård, S., Kauppinen, T., Stücker, I., Shaham, J., Heederik, D., Ahrens, W., Bergdahl, I., Cenée, S., Hooiveld, M., Randem, B.G., Johansen, C., Ferro, G., and Kromhout, H.

Subjects
Adult, Male, MESH: Accidents, Traffic, Time Factors, Risk fatal industrial accidents death external causes asphalt workers, Coronacrisis-Taverne, Short Report, MESH: Risk Assessment, Risk Assessment, MESH: Cause of Death, Cohort Studies, Interventional oncology [UMCN 1.5], MESH: Accidents, Occupational, Cause of Death, MESH: Hydrocarbons, Determinants in Health and Disease [EBP 1], Accidents, Occupational, Humans, MESH: Cohort Studies, MESH: Humans, MESH: Middle Aged, MESH: Time Factors, Accidents, Traffic, MESH: Adult, Middle Aged, MESH: Male, Hydrocarbons, Europe, Suicide, MESH: Suicide, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe
Abstract

Item does not contain fulltext The hypothesis that asphalt workers are at increased risk of mortality from industrial accidents and other external causes was tested. Mortality rates for external and violent causes of death in a cohort of asphalt industry employees from seven European countries and Israel were compared to that of the general population. There was no evidence that mortality from external causes was increased among long term employees in asphalt application and mixing. There was an increased risk for mortality due to external causes among short term workers. However, none of the fatal accidents among short term workers appear to have occurred during employment in the studied asphalt companies. Overall, no evidence was found supporting the hypothesis that asphalt workers are at increased risk of fatal industrial or road accidents. Mortality from other external causes did not increase in this population as a whole, but increased risks among short term workers deserve further attention.

Published
2003

13. Cancer mortality among European asphalt workers: An international epidemiological study. II. Exposure to bitumen fume and other agents

Author

Boffetta, P., Burstyn, I., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Jarvholm, B., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, and Faculteit Diergeneeskunde

Subjects
asphalt, coal tar, technology, industry, and agriculture, otorhinolaryngologic diseases, Coronacrisis-Taverne, epidemiology, road paving, lung neoplasms, roofing, complex mixtures, mortality, bitumen fume, respiratory tract diseases
Abstract

Background An increased risk of lung cancers among asphalt workers has been suggested in epidemiological studies based on large scale statistical analyses. Methods In a multi‐country study of 29,820 male workers employed in road paving, asphalt mixing and roofing, 32,245 ground and building construction workers and 17,757 other workers from Denmark, Finland, France, Germany, Israel, the Netherlands, Norway, and Sweden, with mortality that was documented from 1953–2000. Exposures to bitumen fume, coal tar, 4–6 ring polycyclic aromatic hydrocarbons, organic vapor, diesel exhaust, asbestos, and silica dust were assessed via a job‐exposure matrix. Standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) based on national mortality rates, as well as relative risks (RRs) based on Poisson regression models were calculated. Results The SMR of lung cancer among workers exposed to bitumen fume (1.08, 95% CI 0.99–1.18) was comparable to that of non‐exposed workers (SMR 1.05, 95% CI 0.92–1.19). In a sub‐cohort of bitumen‐exposed workers without exposure to coal tar, the SMR of lung cancer was 1.23 (95% CI 1.02–1.48). The analysis based on the semi‐quantitative, matrix‐based exposures in the whole cohort did not suggest an increased lung cancer risk following exposure to bitumen fume. However, in an analysis restricted to road pavers, based on quantitative estimate of bitumen fume exposure, a dose‐response was suggested for average level of exposure, applying a 15‐year lag, which was marginally reduced after adjustment for co‐exposure to coal tar. The results for cancer of the head and neck were similar to those of lung cancer, although they were based on a smaller number of deaths. There was no clear suggestion of an association with bitumen fume for any other neoplasm. Conclusions The results of the analysis by bitumen fume exposure do not allow us to conclude on the presence or absence of a causal link between exposure to bitumen fume and risk of cancer of the lung and the head and neck. Am. J. Ind. Med. 43:28–39, 2003. © 2003 Wiley‐Liss, Inc.

Published
2003

14. Estimating exposures in the asphalt industry for an international epidemiological cohort study of cancer risk

Author

Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.J., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Langard, S., Randem, B., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ribak, J., Kromhout, H., Universiteit Utrecht, and Faculteit Diergeneeskunde

Subjects
exposure matrix, otorhinolaryngologic diseases, technology, industry, and agriculture, Coronacrisis-Taverne, tar, complex mixtures, bitumen
Abstract

Background An exposure matrix (EM) for known and suspected carcinogens was required for a multicenter international cohort study of cancer risk and bitumen among asphalt workers. Methods Production characteristics in companies enrolled in the study were ascertained through use of a company questionnaire (CQ). Exposures to coal tar, bitumen fume, organic vapor, polycyclic aromatic hydrocarbons, diesel fume, silica, and asbestos were assessed semi‐quantitatively using information from CQs, expert judgment, and statistical models. Exposures of road paving workers to bitumen fume, organic vapor, and benzo(a)pyrene were estimated quantitatively by applying regression models, based on monitoring data, to exposure scenarios identified by the CQs. Results Exposures estimates were derived for 217 companies enrolled in the cohort, plus the Swedish asphalt paving industry in general. Most companies were engaged in road paving and asphalt mixing, but some also participated in general construction and roofing. Coal tar use was most common in Denmark and The Netherlands, but the practice is now obsolete. Quantitative estimates of exposure to bitumen fume, organic vapor, and benzo(a)pyrene for pavers, and semi‐quantitative estimates of exposure to these agents among all subjects were strongly correlated. Semi‐quantitative estimates of exposure to bitumen fume and coal tar exposures were only moderately correlated. EM assessed non‐monotonic historical decrease in exposures to all agents assessed except silica and diesel exhaust. Conclusions We produced a data‐driven EM using methodology that can be adapted for other multicenter studies. Am. J. Ind. Med. 43:3–17, 2003. © 2003 Wiley‐Liss, Inc.

Published
2003

15. Cancer mortality among European asphalt workers: An international epidemiological study. I. Results of the analysis based on job titles

Author

Boffetta, P., Burstyn, I., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Jarvholm, B., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ahrens, W., Bergdahl, I.A., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, and Faculteit Diergeneeskunde

Subjects
asphalt, Coronacrisis-Taverne, epidemiology, road paving, occupational exposures, lung neoplasms, roofing, mortality
Abstract

Background Inhalation of bitumen fumes is potentially carcinogenic to humans. Methods We conducted a study of 29,820 male workers exposed to bitumen in road paving, asphalt mixing and roofing, 32,245 ground and building construction workers unexposed to bitumen, and 17,757 workers not classifiable as bitumen workers, from Denmark, Finland, France, Germany, Israel, the Netherlands, Norway, and Sweden, with mortality follow‐up during 1953–2000. We calculated standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) based on national mortality rates. Poisson regression analyses compared mortality of bitumen workers to that of building or ground construction workers. Results The overall mortality was below expectation in the total cohort (SMR 0.92, 95% CI 0.90–0.94) and in each group of workers. The SMR of lung cancer was higher among bitumen workers (1.17, 95% CI 1.04–1.30) than among workers in ground and building construction (SMR 1.01, 95% CI 0.89–1.15). In the internal comparison, the relative risk (RR) of lung cancer mortality among bitumen workers was 1.09 (95% CI 0.89–1.34). The results of cancer of the head and neck were similar to those of lung cancer, based on a smaller number of deaths. There was no suggestion of an association between employment in bitumen jobs and other cancers. Conclusions European workers employed in road paving, asphalt mixing and other jobs entailing exposure to bitumen fume might have experienced a small increase in lung cancer mortality risk, compared to workers in ground and building construction. However, exposure assessment was limited and confounding from exposure to carcinogens in other industries, tobacco smoking, and other lifestyle factors cannot be ruled out. Am. J. Ind. Med. 43:18–27, 2003. © 2003 Wiley‐Liss, Inc.

Published
2003

16. Performance of different exposure assessment approaches in a study of bitumen fume exposure and lung cancer mortality

Author

Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.J., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Brunekreef, B., Langard, S., Randem, B., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ferro, G., Kromhout, H., Universiteit Utrecht, and Faculteit Diergeneeskunde

Subjects
exposure reconstruction methodology, model fit, quantitative exposure assessment, cohort study, Coronacrisis-Taverne, respiratory tract diseases
Abstract

Background We compared performance of different exposure assessment approaches in a cohort study of cancer risk among European asphalt workers. Methods Three bitumen fume exposure indices (duration of exposure (years), average exposure (mg/m3) and cumulative exposure (mg/m3*years)) and two latency models (with and without a 15 year lag) were considered for an association between lung cancer mortality and bitumen fume. Results There was no association between lung cancer risk and either duration or cumulative exposure. However, there was the suggestion of an increase in lung cancer risk accompanying rise in average exposure. Only models with average bitumen fume exposure (with or without lag) improved model fit, albeit to the same extent. Conclusions Constructing quantitative indices of exposure intensity was justified because they produced the greatest improvement in fit of models that explored possible relationship between bitumen fume exposure and lung cancer risk. The identified associations require further investigation. Am. J. Ind. Med. 43:40–48, 2003. © 2003 Wiley‐Liss, Inc.

Published
2003

17. Mortality from obstructive lung diseases and exposure to polycyclic aromatic hydrocarbons among asphalt workers

Author

Burstyn, I., Boffetta, P., Heederik, D.J.J., Partanen, T.J., Kromhout, H., Svane, O., Langard, S., Frentzel-Beyme, R., Kauppinen, T., Stucker, I., Shaham, J., Ahrens, W., Cenee, S., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Schill, W., Universiteit Utrecht, Faculteit Diergeneeskunde, Secretariat, U754, Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Unit of Environment Cancer Epidemiology, IARC, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Bremen Institute for Prevention Research and Social Medicine, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Institute of Cancer Epidemiology, Danish Cancer Society, Universiteit Utrecht, and Faculteit Diergeneeskunde

Subjects
Male, Chronic bronchitis, Pathology, Epidemiology, Abbreviations: ICD-9, MESH: Risk Assessment, MESH: Occupational Exposure, Cohort Studies, Ninth Revision, chemistry.chemical_compound, Road Construction Workers’ Exposure Matrix, Determinants in Health and Disease [EBP 1], Israel, Polycyclic Aromatic Hydrocarbons, MESH: Cohort Studies, Coal Tar, Inhalation Exposure, MESH: Time, Respiratory disease, MESH: Israel, MESH: Follow-Up Studies, Polycyclic aromatic hydrocarbon, Causality, Europe, Occupational Diseases, Benzo(a)pyrene, Bronchitis, MESH: Inhalation Exposure, ICD-9, medicine.drug, MESH: Occupational Diseases, medicine.medical_specialty, Coronacrisis-Taverne, MESH: Coal Tar, MESH: Causality, Risk Assessment, ICD-9 [Abbreviations], Time, Occupational medicine, MESH: Polycyclic Hydrocarbons, Aromatic, International Classification of Diseases, Interventional oncology [UMCN 1.5], Occupational Exposure, Environmental health, polycyclic aromatic hydrocarbon, MESH: Hydrocarbons, MESH: Lung Diseases, Obstructive, medicine, Humans, Lung Diseases, Obstructive, Coal tar, Asthma, MESH: Humans, business.industry, PAH, medicine.disease, Hydrocarbons, MESH: Male, respiratory tract diseases, ROCEM, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, Aromatic, Follow-Up Studies
Abstract

Item does not contain fulltext Work in the asphalt industry has been associated with nonmalignant respiratory morbidity and mortality, but the evidence is not consistent. A historical cohort of asphalt workers included 58,862 men (911,209 person-years) first employed between 1913 and 1999 in companies applying and mixing asphalt in Denmark, Finland, France, Germany, Israel, the Netherlands, and Norway. The relations between mortality from nonmalignant respiratory diseases (including the obstructive lung diseases: chronic bronchitis, emphysema, and asthma) and specific chemical agents and mixtures were evaluated using a study-specific exposure matrix. Mortality from obstructive lung diseases was associated with the estimated cumulative and average exposures to polycyclic aromatic hydrocarbons and coal tar (p values of the test for linear trend = 0.06 and 0.01, respectively). The positive association between bitumen fume exposure and mortality from obstructive lung diseases was weak and not statistically significant; confounding by simultaneous exposure to coal tar could not be excluded. The authors lacked data on smoking and full occupational histories. In conclusion, exposures to polycyclic aromatic hydrocarbons, originating from coal tar and possibly from bitumen fume, may have contributed to mortality from obstructive lung diseases among asphalt workers, but confounding and bias cannot be ruled out as an explanation for the observed associations.

Published
2003

18. Estimating exposures in the asphalt industry for an international epidemiological cohort study of cancer risk

Author

Burstyn, I., Boffetta, P., Kauppinen, T., Heikkila, P., Svane, O., Partanen, T.A., Stucker, I., Frentzel-Beyme, R., Ahrens, W., Merzenich, H., Heederik, D.J.J., Hooiveld, M., Langard, S., Randem, B.G., Jarvholm, B., Bergdahl, I.A., Shaham, J., Ribak, J., Kromhout, H., Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Unit of Environment Cancer Epidemiology, IARC, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Danish Working Environment Service, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bremen Institute for Prevention Research and Social Medicine, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Occupational Medicine, Department of Public Health and Clinical Medicine, Umea University Hospital, Occupational Cancer Department, National Institute of Occupational and Environmental Health, Secretariat, U754, Universiteit Utrecht, and Faculteit Diergeneeskunde

Subjects
Coronacrisis-Taverne, MESH: Epidemiologic Methods, MESH: Risk Assessment, complex mixtures, Risk Assessment, MESH: Occupational Exposure, Cohort Studies, exposure matrix, Interventional oncology [UMCN 1.5], Occupational Exposure, MESH: Hydrocarbons, Determinants in Health and Disease [EBP 1], otorhinolaryngologic diseases, Humans, Multicenter Studies as Topic, tar, Israel, MESH: Cohort Studies, bitumen, Inhalation Exposure, MESH: Humans, Models, Statistical, MESH: Israel, technology, industry, and agriculture, Hydrocarbons, respiratory tract diseases, Europe, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Multicenter Studies as Topic, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, MESH: Inhalation Exposure, Epidemiologic Methods, MESH: Models, Statistical
Abstract

Background An exposure matrix (EM) for known and suspected carcinogens was required for a multicenter international cohort study of cancer risk and bitumen among asphalt workers. Methods Production characteristics in companies enrolled in the study were ascertained through use of a company questionnaire (CQ). Exposures to coal tar, bitumen fume, organic vapor, polycyclic aromatic hydrocarbons, diesel fume, silica, and asbestos were assessed semi‐quantitatively using information from CQs, expert judgment, and statistical models. Exposures of road paving workers to bitumen fume, organic vapor, and benzo(a)pyrene were estimated quantitatively by applying regression models, based on monitoring data, to exposure scenarios identified by the CQs. Results Exposures estimates were derived for 217 companies enrolled in the cohort, plus the Swedish asphalt paving industry in general. Most companies were engaged in road paving and asphalt mixing, but some also participated in general construction and roofing. Coal tar use was most common in Denmark and The Netherlands, but the practice is now obsolete. Quantitative estimates of exposure to bitumen fume, organic vapor, and benzo(a)pyrene for pavers, and semi‐quantitative estimates of exposure to these agents among all subjects were strongly correlated. Semi‐quantitative estimates of exposure to bitumen fume and coal tar exposures were only moderately correlated. EM assessed non‐monotonic historical decrease in exposures to all agents assessed except silica and diesel exhaust. Conclusions We produced a data‐driven EM using methodology that can be adapted for other multicenter studies. Am. J. Ind. Med. 43:3–17, 2003. © 2003 Wiley‐Liss, Inc.

Published
2002

19. Metabolic gene polymorphism frequencies in control populations

Author

Garte, S., Gaspari, L., Alexandrie, A. K., Ambrosone, C., Autrup, H., Autrup, J. L., Baranova, H., Bathum, L., Benhamou, S., Boffetta, P., Bouchardy, C., Breskvar, K., Brockmoller, J., Cascorbi, I., Clapper, M. L., Coutelle, C., Daly, A., Omo, M., Dolzan, V., Dresler, C. M., Fryer, A., Haugen, A., Hein, D. W., Hildesheim, A., Hirvonen, A., Hsieh, L. L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Kihara, M., Kiyohara, C., Kremers, P., Lazarus, P., Le Marchand, L., Lechner, M. C., Lieshout, E. M., Stephanie London, Manni, J. J., Maugard, C. M., Morita, S., Nazar-Stewart, V., Noda, K., Oda, Y., Parl, F. F., Pastorelli, R., Persson, I., Peters, W. H., Rannug, A., Rebbeck, T., Risch, A., Roelandt, L., Romkes, M., Ryberg, D., Salagovic, J., Schoket, B., Seidegard, J., Shields, P. G., Sim, E., Sinnet, D., Strange, R. C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M. C., and Taioli, E.

Subjects
Polymorphism, Genetic, Metabole aspecten van maag-, darm- en leveraandoeningen, Cytochrome P-450 Enzyme System, Databases, Factual, Gene Frequency, Genetic Linkage, Neoplasms, Black People, Humans, Metabolic aspects of gastrointestinal diseases, Genetic Predisposition to Disease, White People
Abstract

Item does not contain fulltext Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.

Published
2001

20. Lung Cancer Risk Among Hairdressers: A Pooled Analysis of Case-Control Studies Conducted Between 1985 and 2010

Author

Olsson, A. C., primary, Xu, Y., additional, Schuz, J., additional, Vlaanderen, J., additional, Kromhout, H., additional, Vermeulen, R., additional, Peters, S., additional, Stucker, I., additional, Guida, F., additional, Bruske, I., additional, Wichmann, H.-E., additional, Consonni, D., additional, Landi, M. T., additional, Caporaso, N., additional, Tse, L. A., additional, Yu, I. T.-s., additional, Siemiatycki, J., additional, Richardson, L., additional, Mirabelli, D., additional, Richiardi, L., additional, Simonato, L., additional, Gustavsson, P., additional, Plato, N., additional, Jockel, K.-H., additional, Ahrens, W., additional, Pohlabeln, H., additional, Tardon, A., additional, Zaridze, D., additional, Marcus, M. W., additional, 't Mannetje, A., additional, Pearce, N., additional, McLaughlin, J., additional, Demers, P., additional, Szeszenia-Dabrowska, N., additional, Lissowska, J., additional, Rudnai, P., additional, Fabianova, E., additional, Dumitru, R. S., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, Boffetta, P., additional, Fortes, C., additional, Bueno-de-Mesquita, B., additional, Kendzia, B., additional, Behrens, T., additional, Pesch, B., additional, Bruning, T., additional, and Straif, K., additional

Published
2013
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21. Hormone use and risk for lung cancer: a pooled analysis from the International Lung Cancer Consortium (ILCCO)

Author

Pesatori, A C, primary, Carugno, M, additional, Consonni, D, additional, Hung, R J, additional, Papadoupolos, A, additional, Landi, M T, additional, Brenner, H, additional, Müller, H, additional, Harris, C C, additional, Duell, E J, additional, Andrew, A S, additional, McLaughlin, J R, additional, Schwartz, A G, additional, Wenzlaff, A S, additional, and Stucker, I, additional

Published
2013
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22. Lung cancer risk in painters: results from the SYNERGY pooled analysis

Author

Guha, N., primary, Olsson, A., additional, Kromhout, H., additional, Vermeulen, R., additional, Bruning, T., additional, Pesch, B., additional, Kendzia, B., additional, Wichmann, H.-E., additional, Bruske, I., additional, Stucker, I., additional, De Matteis, S., additional, Landi, M. T., additional, Caporaso, N., additional, Siemiatycki, J., additional, Gustavsson, P., additional, Plato, N., additional, Merletti, F., additional, Mirabelli, D., additional, Richiardi, L., additional, Ahrens, W., additional, Pohlabeln, H., additional, Jockel, K.-H., additional, Zaridze, D., additional, Cassidy, A., additional, Lissowska, J., additional, Szeszenia-Dabrowska, N., additional, Benhamou, S., additional, Slamova, A., additional, Foretova, L., additional, Janout, V., additional, Rudnai, P., additional, Fabianova, E., additional, Dumitru, R. S., additional, Forastiere, F., additional, Bueno-de-Mesquita, B., additional, Peters, S., additional, Boffetta, P., additional, Benhaim-Luzon, V., additional, and Straif, K., additional

Published
2011
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23. Lung cancer and exposure to mineral wools: the ICARE study

Author

Guida, F., primary, Lamkarkach, F., additional, Cenee, S., additional, Cyr, D., additional, Gaye, O., additional, Lacourt, A., additional, Brochard, P., additional, Ducamp, S., additional, Paris, C., additional, Fevotte, J., additional, Luce, D., additional, and Stucker, I., additional

Published
2011
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25. Lung cancer risk among cooks and kitchen workers in a pooled analysis of case-control studies in Europe and Canada

Author

Bigert, C., primary, Olsson, A., additional, Gustavsson, P., additional, Bruning, T., additional, Kendzia, B., additional, Pesch, B., additional, Jockel, K.-H., additional, Pohlabeln, H., additional, Ahrens, W., additional, Gross, I., additional, Bruske, I., additional, Wichmann, H.-E., additional, Merletti, F., additional, Mirabelli, D., additional, Richiardi, L., additional, Zaridze, D., additional, Cassidy, A., additional, Szeszenia-Dabrowska, N., additional, Rudnai, P., additional, Lissowska, J., additional, Stucker, I., additional, Fabianova, E., additional, Dumitru, R. S., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, Siemiatycki, J., additional, Landi, M. T., additional, Caporaso, N., additional, Brennan, P., additional, Benhamou, S., additional, Benhaim-Luzon, V., additional, Kromhout, H., additional, Vermeulen, R., additional, Peters, S., additional, Consonni, D., additional, Bueno-de-Mesquita, B., additional, Boffetta, P., additional, and Straif, K., additional

Published
2011
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26. Lung cancer risk among hairdressers in SYNERGY - pooled analysis from case-control studies in Europe and Canada

Author

Olsson, A., primary, Guha, N., additional, Bruning, T., additional, Pesch, B., additional, Kendzia, B., additional, Wichmann, H.-E., additional, Bruske, I., additional, Stucker, I., additional, Pesatori, A. C., additional, Landi, M. T., additional, Caporaso, N., additional, Siemiatycki, J., additional, Gustavsson, P., additional, Plato, N., additional, Merletti, F., additional, Mirabelli, D., additional, Richiardi, L., additional, Ahrens, W., additional, Pohlabeln, H., additional, Jockel, K.-H., additional, Zaridze, D., additional, Cassidy, A., additional, Lissowska, J., additional, Szeszenia-Dabrowska, N., additional, Benhamou, S., additional, Schejbalova, M., additional, Foretova, L., additional, Janout, V., additional, Rudnai, P., additional, Fabianova, E., additional, Dumitru, R. S., additional, Forastiere, F., additional, Bueno-de-Mesquita, B., additional, Benhaim-Luzon, V., additional, Peters, S., additional, Vermeulen, R., additional, Boffetta, P., additional, Kromhout, H., additional, and Straif, K., additional

Published
2011
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27. Exposure-response relation for occupational exposure to respirable quartz and lung cancer risk: performance of a quantitative vs a semi-quantitative job-exposure matrix

Author

Peters, S., primary, Vermeulen, R., additional, Portengen, L., additional, Olsson, A., additional, Wichmann, H.-E., additional, Bruske, I., additional, Consonni, D., additional, Cattaneo, A., additional, Bertazzi, P. A., additional, Siemiatycki, J., additional, Richiardi, L., additional, Mirabelli, D., additional, Simonato, L., additional, Gustavsson, P., additional, Jockel, K.-H., additional, Ahrens, W., additional, Pohlabeln, H., additional, Boffetta, P., additional, Brennan, P., additional, Forastiere, F., additional, Stucker, I., additional, Benhamou, S., additional, Bueno-de-Mesquita, B., additional, Plato, N., additional, Lavoue, J., additional, Dahmann, D., additional, Fevotte, J., additional, Kendzia, B., additional, Vincent, R., additional, Savary, B., additional, Cavallo, D., additional, Pesch, B., additional, Bruning, T., additional, Straif, K., additional, and Kromhout, H., additional

Published
2011
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28. Lung cancer risk among men by occupation and industry in SYNERGY - pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer

Author

Mirabelli, D., primary, Merletti, F., additional, Richiardi, L., additional, Corbin, M., additional, Franch, I. M., additional, Olsson, A., additional, Gustavsson, P., additional, Kromhout, H., additional, Peters, S., additional, Vermeulen, R., additional, Bruske, I., additional, Pesch, B., additional, Bruning, T., additional, Gross, I., additional, Siemiatycki, J., additional, Pintos, J., additional, Wichmann, H.-E., additional, Consonni, D., additional, Plato, N., additional, Ahrens, W., additional, Pohlabeln, H., additional, Lissowska, J., additional, Szeszenia-Dabrowska, N., additional, Cassidy, A., additional, Zaridze, D., additional, Stucker, I., additional, Benhamou, S., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, Rudnai, P., additional, Fabianova, E., additional, Mates, D., additional, Bueno-de-Mesquita, B., additional, Boffetta, P., additional, and Straif, K., additional

Published
2011
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29. SYNERGY epidemiological database and some results on smoking by major histological subtypes of lung cancer

Author

Pesch, B., primary, Kendzia, B., additional, Gustavsson, P., additional, Jockel, K.-H., additional, Johnen, G., additional, Pohlabeln, H., additional, Olsson, A., additional, Ahrens, W., additional, Bruske, I., additional, Wichmann, H.-E., additional, Merletti, F., additional, Richiardi, L., additional, Simonato, L., additional, Fortes, C., additional, Siemiatycki, J., additional, Pintos, J., additional, Consonni, D., additional, Landi, M. T., additional, Caporaso, N., additional, Zaridze, D., additional, Cassidy, A., additional, Szeszenia-Dabrowska, N., additional, Rudnai, P., additional, Lissowska, J., additional, Stucker, I., additional, Fabianova, E., additional, Dumitru, R. S., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, McLaughlin, J., additional, Demers, P., additional, Peters, S., additional, Vermeulen, R., additional, Kromhout, H., additional, Bueno-de-Mesquita, B., additional, Brennan, P., additional, Boffetta, P., additional, Straif, K., additional, and Bruning, T., additional

Published
2011
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30. Occupational exposure to organic dust increases lung cancer risk in the general population

Author

Peters, S., primary, Kromhout, H., additional, Olsson, A., additional, Wuchmann, H.-E., additional, Bruske, I., additional, Consonni, D., additional, Landi, M. T., additional, Caporaso, N., additional, Siemiatycki, J., additional, Richiardi, L., additional, Mirabelli, D., additional, Simonato, L., additional, Gustavsson, P., additional, Plato, N., additional, Jockel, K.-H., additional, Ahrens, W., additional, Pohlabeln, H., additional, Boffetta, P., additional, Brennan, P., additional, Zaridze, D., additional, Cassidy, A., additional, Lissowska, J., additional, Szeszenia-Dabrowska, N., additional, Rudnai, P., additional, Fabianova, E., additional, Forastiere, F., additional, Bencko, V., additional, Foretova, L., additional, Janout, V., additional, Stucker, I., additional, Dumitru, R. S., additional, Benhamou, S., additional, Bueno-de-Mesquita, B., additional, Kendzia, B., additional, Pesch, B., additional, Straif, K., additional, Bruning, T., additional, and Vermeulen, R., additional

Published
2011
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32. Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A HuGE-GSEC Review

Author

Raimondi, S, primary, Paracchini, V, additional, Autrup, H, additional, Barros-Dios, J., additional, Benhamou, S, additional, Boffetta, P, additional, Cote, M., additional, Dialyna, I., additional, Dolzan, V, additional, Filiberti, R, additional, Garte, S, additional, Hirvonen, A, additional, Husgafvel-Pursiainen, K, additional, Imyanitov, E., additional, Kalina, I, additional, Kang, D, additional, Kiyohara, C, additional, Kohno, T, additional, Kremers, P, additional, Lan, Q, additional, London, S, additional, Povey, A., additional, Rannug, A, additional, Reszka, E, additional, Risch, A, additional, Romkes, M, additional, Schneider, J, additional, Seow, A, additional, Shields, P., additional, Sobti, R., additional, Sorensen, M, additional, Spinola, M, additional, Spitz, M., additional, Strange, R., additional, Stucker, I, additional, Sugimura, H, additional, To-Figueras, J, additional, Tokudome, S, additional, Yang, P, additional, Yuan, J-M, additional, Warholm, M, additional, and Taioli, E, additional

Published
2006
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33. Age and gender differences in the association between MPO 463>A and lung cancer. Results from the genetic susceptibility to environmental carcinogens pooled analysis

Author

Frullanti, E., primary, Forti, S., additional, Raimondi, S., additional, Benhamou, S., additional, Cascorbi, I., additional, Marchand, L. Le, additional, London, S.J., additional, Risch, A., additional, Spitz, M.R., additional, Stucker, I., additional, Yang, P., additional, and Taioli, E., additional

Published
2006
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40. Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer

Author

Gao, C., Patel, C. J., Michailidou, K., Peters, U., Gong, J., Schildkraut, J., Schumacher, F. R., Zheng, W., Boffetta, P., Stucker, I., Willett, W., Gruber, S., Easton, D. F., Hunter, D. J., Sellers, T. A., Haiman, C., Henderson, B. E., Hung, R. J., Amos, C., Pierce, B. L., Lindström, S., Kraft, P., Hunter, D., Henderson, B., Sellers, T., Hopper, J. L., Southey, M. C., Makalic, E., Schmidt, D. F., Fletcher, O., Peto, J., Gibson, L., Silva, I. S., Waisfisz, Q., Meijers-Heijboer, H., Adank, M., van der Luijt, R. B., Uitterlinden, A. G., Hofman, A., Meindl, A., Schmutzler, R. K., Müller-Myhsok, B., Lichtner, P., Nevanlinna, H., Muranen, T. A., Aittomäki, K., Blomqvist, C., Chang-Claude, J., Hein, R., Dahmen, N., Beckman, L., Hall, P., Czene, K., Irwanto, A., Liu, J., Turnbull, C., Rahman, N., Cramer, D., Terry, K., Sutphen, R., Narod, S., Phelan, C., Risch, H., Pharoah, P., Gayther, S., Menon, U., Wentzensen, N., Human genetics, Amsterdam Neuroscience - Complex Trait Genetics, CCA - Oncogenesis, CCA - Quality of life, and Gao, C. and Patel, C.J. and Michailidou, K. and Peters, U. and Gong, J. and Schildkraut, J. and Schumacher, F.R. and Zheng, W. and Boffetta, P. and Stucker, I. and Willett, W. and Gruber, S. and Easton, D.F. and Hunter, D.J. and Sellers, T.A. and Haiman, C. and Henderson, B.E. and Hung, R.J. and Amos, C. and Pierce, B.L. and Lindström, S. and Kraft, P. and Hunter, D. and Henderson, B. and Sellers, T. and Amos, C. and Hopper, J.L. and Southey, M.C. and Makalic, E. and Schmidt, D.F. and Fletcher, O. and Peto, J. and Gibson, L. and Silva, I.S. and Waisfisz, Q. and Meijers-Heijboer, H. and Adank, M. and van der Luijt, R.B. and Uitterlinden, A.G. and Hofman, A. and Meindl, A. and Schmutzler, R.K. and Müller-Myhsok, B. and Lichtner, P. and Nevanlinna, H. and Muranen, T.A. and Aittomäki, K. and Blomqvist, C. and Chang-Claude, J. and Hein, R. and Dahmen, N. and Beckman, L. and Hall, P. and Czene, K. and Irwanto, A. and Liu, J. and Turnbull, C. and Rahman, N. and Cramer, D. and Terry, K. and Sutphen, R. and Narod, S. and Phelan, C. and Risch, H. and Pharoah, P. and Gayther, S. and Menon, U. and Wentzensen, N.

Subjects
Male, Oncology, obesity, Epidemiology, smoking, adcy3 gene, health statu, Colorectal Neoplasm, cancer risk, genetic risk, lung tumor, Body Mass Index, genetic heterogeneity, 0302 clinical medicine, single nucleotide polymorphism, Epidemiology of cancer, Odds Ratio, tnn13k gene, 030212 general & internal medicine, sec16b gene, 2. Zero hunger, prostate tumor, breast tumor, adult, public health, allele, ovary cancer, General Medicine, prostate cancer, 3. Good health, gnpda2 gene, waist hip ratio, female, Phenotype, risk factor, priority journal, ovary tumor, 030220 oncology & carcinogenesis, child health, gnat2 gene, childhood obesity, Breast Neoplasm, cancer epidemiology, Human, single nucleotide polymorphism, Adiposity, medicine.medical_specialty, gpr61 gene, colorectal cancer, Polymorphism, Single Nucleotide, Article, olfm4 gene, Regression Analysi, 03 medical and health sciences, mc4r gene, Breast cancer, SDG 3 - Good Health and Well-being, tmem18 gene, Internal medicine, pleiotropy, Mendelian randomization, medicine, cancer, controlled study, Mendelian Randomization Analysi, Risk factor, gene, Lung cancer, Post-GWAS study, health risk, genome-wide association study, fto gene, Waist-Hip Ratio, business.industry, Ovarian Neoplasm, Waist-to-hip ratio, birth weight, Cancer, Odds ratio, medicine.disease, major clinical study, Lung Neoplasm, lung cancer, confidence interval, genetic variation, Prostatic Neoplasm, Neoplasm, genetic, business, Body mass index, body ma, colorectal tumor
Abstract

Background: Adiposity traits have been associated with risk of many cancers in observational studies, but whether these associations are causal is unclear. Mendelian randomization (MR) uses genetic predictors of risk factors as instrumental variables to eliminate reverse causation and reduce confounding bias. We performed MR analyses to assess the possible causal relationship of birthweight, childhood and adult body mass index (BMI), and waist-hip ratio (WHR) on the risks of breast, ovarian, prostate, colorectal and lung cancers. Methods: We tested the association between genetic risk scores and each trait using summary statistics from published genome-wide association studies (GWAS) and from 51 537 cancer cases and 61 600 controls in the Genetic Associations and Mechanisms in Oncology (GAME-ON) Consortium. Results: We found an inverse association between the genetic score for childhood BMI and risk of breast cancer [odds ratio (OR)=0.71 per standard deviation (s.d.) increase in childhood BMI; 95% confidence interval (CI): 0.60, 0.80; P=6.5×10-5). We also found the genetic score for adult BMI to be inversely associated with breast cancer risk (OR=0.66 per s.d. increase in BMI; 95% CI: 0.57, 0.77; P=2.5×10-7), and positively associated with ovarian cancer (OR=1.35; 95% CI: 1.05, 1.72; P=0.017), lung cancer (OR=1.27; 95% CI: 1.09, 1.49; P=2.9×10-3) and colorectal cancer (OR=1.39; 95% CI: 1.06, 1.82, P=0.016). The inverse association between genetically predicted adult BMI and breast cancer risk remained even after adjusting for directional pleiotropy via MR-Egger regression. Conclusions: Findings from this study provide additional understandings of the complex relationship between adiposity and cancer risks. Our results for breast and lung cancer are particularly interesting, given previous reports of effect heterogeneity by menopausal status and smoking status. © The Author 2016; Published by Oxford University Press on behalf of the International Epidemiological Association All rights reserved.

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44. Influence of a mutation reducing the catalytic activity of the cytochrome P450 CYP2D6 on lung cancer susceptibility.

Author

Legrand, M, Stucker, I, Marez, D, Sabbagh, N, Lo-Guidice, J M, and Broly, F

Abstract

The possible association between lung cancer and the CYP2D6*9 mutant allele, which reduces the catalytic activity of cytochrome P450 CYP2D6, was examined by PCR-SSCP using peripheral blood DNA from 249 cases of lung cancer and 265 controls, with detailed data on smoking. The CYP2D6*9 mutant allele was present in 4.9% of controls and 6% of cases. Adjusted for age, hospital and smoking, the odds ratio (OR) of lung cancer associated with the presence of the CYP2D6*9 mutant allele was 1.2 [95% confidence interval (CI) 0.5-2.9]. According to histological type, adenocarcinoma and small cell carcinoma were not associated with the presence of the CYP2D6*9 mutant allele and a non-significant higher occurrence of the mutant allele was observed for squamous cell carcinoma (OR 1.74, 95% CI 0.6-4.8). Moreover, no associations were observed upon stratification by number of pack-years of cigarette smoking. These results do not confirm an earlier report that this CYP2D6*9 mutant allele may be an additional risk factor for the development of lung cancer.

Published
1996
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45. Determinants of smoking initiation among women in five European countries: a cross-sectional survey.

Author

Oh DL, Heck JE, Dresler C, Allwright S, Haglund M, Del Mazo SS, Kralikova E, Stucker I, Tamang E, Gritz ER, Hashibe M, Oh, Debora L, Heck, Julia E, Dresler, Carolyn, Allwright, Shane, Haglund, Margaretha, Del Mazo, Sara S, Kralikova, Eva, Stucker, Isabelle, and Tamang, Elizabeth

Abstract

Background: The rate of smoking and lung cancer among women is rising in Europe. The primary aim of this study was to determine why women begin smoking in five different European countries at different stages of the tobacco epidemic and to determine if smoking is associated with certain characteristics and/or beliefs about smoking.Methods: A cross-sectional telephone survey on knowledge and beliefs about tobacco was conducted as part of the Women in Europe Against Lung Cancer and Smoking (WELAS) Project. A total of 5,000 adult women from France, Ireland, Italy, Czech Republic, and Sweden were interviewed, with 1,000 from each participating country. All participants were asked questions about demographics, knowledge and beliefs about smoking, and their tobacco use background. Current and former smokers also were asked questions about smoking initiation. Basic statistics on the cross-sectional data was reported with chi-squared and ANOVA p-values. Logistic regression was used to analyze ever versus never smokers. Linear regression analyses were used to analyze age of smoking initiation.Results: Being older, being divorced, having friends/family who smoke, and having parents who smoke were all significantly associated with ever smoking, though the strength of the associations varied by country. The most frequently reported reason for initiation smoking was friend smoking, with 62.3% of ever smokers reporting friends as one of the reasons why they began smoking. Mean age of smoking initiation was 18.2 years and over 80% of participants started smoking by the age of 20. The highest levels of young initiators were in Sweden with 29.3% of women initiating smoking at age 14-15 and 12.0% initiating smoking younger than age 14. The lowest level of young initiators was in the Czech Republic with 13.7% of women initiating smoking at age 14-15 and 1.4% of women initiating smoking younger than age 14. Women who started smoking because their friends smoked or to look 'cool' were more likely to start smoking at a younger age. Women who started smoking to manage stress or to feel less depressed were more likely to start smoking at an older age.Conclusions: In all five participating countries, friends were the primary factor influencing ever smoking, especially among younger women. The majority of participants began smoking in adolescence and the average reported age of smoking initiation was youngest in Sweden and oldest in the Czech Republic. [ABSTRACT FROM AUTHOR]

Published
2010
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48. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author

Philip Lazarus, Claire M. Healy, Richard B. Hayes, Rolando Herrero, Elaine M. Smith, Stefania Boccia, Leonardo F. Boaventura Rios, Paolo Boffetta, Dana Mates, Jerry Polesel, Marta Vilensky, Jose P. Zevallos, Diego Serraino, Gypsyamber D'Souza, Joshua E. Muscat, Kirsten B. Moysich, Yuan Chin Amy Lee, Mark P. Purdue, Carlo La Vecchia, Heribert Ramroth, Thomas L. Vaughan, Peter Thomson, Karl T. Kelsey, Nicola Torelli, Wolfgang Ahrens, Hermann Brenner, Lorenzo Richiardi, Victor Wünsch-Filho, Kristina Kjærheim, Beata Swiatkowska, Keitaro Matsuo, Fabio Levi, Erich M. Sturgis, Eva Negri, Lorenzo Simonato, Danièle Luce, Guo Pei Yu, Chu Chen, Pagona Lagiou, Silvia Franceschi, Andrew F. Olshan, Alexander W. Daudt, Antonio Agudo, Maria Paula Curado, Peter Rudnai, Tatiana V. Macfarlane, Zuo-Feng Zhang, Mia Hashibe, Paul Brennan, Tatiana Natasha Toporcov, Stimson P. Schantz, Maura L. Gillison, Isabelle Stücker, Tongzhang Zheng, Shu Chun Chuang, Oxana Shangina, Eleonora Fabianova, Hal Morgenstern, David I. Conway, Valeria Edefonti, Cristina Bosetti, Ariana Znaor, Leticia Fernandez, Michael D. McClean, Luigino Dal Maso, Neil D. Gross, Stephen M. Schwartz, Ivana Holcatova, Guojun Li, Ana M. B. Menezes, Francesco Pauli, Gioia Di Credico, Deborah M. Winn, Rosalina Jorge Koifman, Gwenn Menvielle, Gabriella Cadoni, Werner Garavello, Jolanda Lissowska, Università degli Studi di Milano [Milano] (UNIMI), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Glasgow, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), TW001500, National Institutes of Health, P30ES010126, National Institute of Environmental Health Sciences, Italian Ministry of Education, Università degli Studi di Milano, Jonsson Comprehensive Cancer Center, International Union Against Cancer, Fondo para la Investigacion Cientifica y Tecnologica Argentina, Institut Hospital del Mar d’Investigacions Mediquès (IMIM), Fundação de Amparo à Pesquisa no Estado de São Paulo, Spanish Government, European Community, Ministry of Science, Research and Arts Baden-Wurttemberg, German Ministry of Education and Research, Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan, Labor and Welfare of Japan, Italian Foundation for Cancer Research, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A.W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D.I., Macfarlane T.V., Thomson P., Agudo A., Znaor A., Boaventura Rios L.F., Toporcov T.N., Franceschi S., Herrero R., Muscat J., Olshan A.F., Zevallos J.P., La Vecchia C., Winn D.M., Sturgis E.M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z.-F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S.M., Vaughan T.L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R.B., Purdue M., Gillison M., Schantz S., Yu G.-P., Brenner H., D'Souza G., Gross N.D., Chuang S.-C., Boffetta P., Hashibe M., Lee Y.-C.A., Dal Maso L., Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W., Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I., Macfarlane, Tatiana V., Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Boaventura Rios, Leonardo F., Toporcov, Tatiana N., Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F., Zevallos, Jose P., La Vecchia, Carlo, Winn, Deborah M., Sturgis, Erich M., Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, Mcclean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M., Vaughan, Thomas L., Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B., Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D., Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Dal Maso, Luigino, Università degli Studi di Milano = University of Milan (UNIMI), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)

Subjects
Male, Oral cavity and pharyngeal cancers, Cancer Research, Bivariate spline model, medicine.medical_treatment, Logistic regression, Substance Misuse, 0302 clinical medicine, Risk Factors, Laryngeal cancer, 80 and over, 2.2 Factors relating to the physical environment, Aetiology, 030223 otorhinolaryngology, Head and neck cancer, Cancer, Aged, 80 and over, Confounding, Middle Aged, 3. Good health, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Bivariate spline models, Cigarette smoking duration, Cigarette smoking intensity, Public Health and Health Services, Female, Oral Surgery, Adult, INHANCE, Oncology and Carcinogenesis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Bivariate analysis, Cigarette Smoking, 03 medical and health sciences, Rare Diseases, Clinical Research, Tobacco, medicine, Humans, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Aged, Settore MED/06 - ONCOLOGIA MEDICA, Tobacco Smoke and Health, business.industry, Prevention, Case-control study, Odds ratio, medicine.disease, Former Smoker, Good Health and Well Being, Case-Control Studies, Dentistry, Smoking cessation, business, Demography
Abstract

Objectives: \ud This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.\ud \ud Materials and Methods: \ud We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.\ud \ud Results: \ud For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.\ud \ud Conclusion: \ud Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Published
2019

49. Occupational socioeconomic risk associations for head and neck cancer in Europe and South America: individual participant data analysis of pooled case-control studies within the INHANCE Consortium

Author

Alexander W. Daudt, Kristina Kjærheim, Paolo Boffetta, Antonio Agudo, Leticia Fernandez, Peter Thomson, Cristina Canova, Alastair Ross, Isabelle Stücker, Diego Serraino, David I. Conway, Marta Vilensky, Rosalina Jorge Koifman, Paul Brennan, Lorenzo Richiardi, Gary J. Macfarlane, Mia Hashibe, Thomas Behrens, Pagona Lagiou, Simone Benhamou, Claire M. Healy, Amy Lee Yuan-Chin, Maria Paula Curado, Victor Wünsch-Filho, Wolfgang Ahrens, Alex D. McMahon, Gwenn Menvielle, Ariana Znaor, Ivana Holcatova, Heribert Ramroth, Jan Hovanec, Danièle Luce, Ana M. B. Menezes, University of Glasgow, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, First Faculty of Medicine Charles University [Prague], University of Athens Medical School [Athens], Universita degli Studi di Padova, University of Turin, Trinity College Dublin, Cancer Registry of Norway, University of Aberdeen, The University of Hong Kong (HKU), L’Hospitalet de Llobregat [Barcelona, Spain], Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), University of Heidelberg, Medical Faculty, Mount Sinai School of Medicine, Department of Psychiatry-Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Bologna, University of Buenos Aires [Argentina], Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Hospital de Clínicas de Porto Alegre (HCPA), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), University of São Paulo (USP), University of Utah School of Medicine [Salt Lake City], National Cancer Institute, NCI: R03CA113157, National Institute of Dental and Craniofacial Research, NIDCR: R03DE016611, European Commission, EC: IC18-CT97-0222, Agence Nationale de la Recherche, ANR, Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP: 01/01768-2, Bundesministerium für Bildung und Forschung, BMBF: 01GB9702/3, Fondation pour la Recherche Médicale, FRM, Fondation ARC pour la Recherche sur le Cancer, ARC, Fondation de France, Ministère des Affaires Sociales et de la Santé, Fifth Framework Programme, FP5: FOR381.88, KFS1069-09-2000, QLK1-CT-2001-00182, Institut National Du Cancer, INCa, Fondo para la Investigación Científica y Tecnológica, FonCyT, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, ANSES, Institut Gustave-Roussy: 88D28, Institut de Veille Sanitaire, InVS, Swiss Cancer Research Foundation: AKT 617, Conway D.I., Hovanec J., Ahrens W., Ross A., Holcatova I., Lagiou P., Serraino D., Canova C., Richiardi L., Healy C., Kjaerheim K., Macfarlane G.J., Thomson P., Agudo A., Znaor A., Brennan P., Luce D., Menvielle G., Stucker I., Benhamou S., Ramroth H., Boffetta P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A., Koifman R., Wunsch-Filho V., Yuan-Chin A.L., Hashibe M., Behrens T., McMahon A.D., Università degli Studi di Padova = University of Padua (Unipd), Università degli studi di Torino = University of Turin (UNITO), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), University of Bologna/Università di Bologna, Universitad de Buenos Aires = University of Buenos Aires [Argentina], Universidade de São Paulo = University of São Paulo (USP), HAL UR1, Admin, and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)

Subjects
Data Analysis, medicine.medical_specialty, Epidemiology, Risk factors in diseases, Occupational prestige, [SDV]Life Sciences [q-bio], Socioeconomic Factor, Head cancer, socioeconomic, Cancer, Cancer Epidemiology, Occupational, Socioeconomic, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology of cancer, medicine, Humans, 030212 general & internal medicine, Socioeconomic status, Càncer de cap, Original Research, business.industry, Factors de risc en les malalties, Prestige, Risk Factor, Head and neck cancer, Public Health, Environmental and Occupational Health, Case-control study, South America, medicine.disease, Neck cancer, Càncer de coll, [SDV] Life Sciences [q-bio], Europe, Data Analysi, Socioeconomic Factors, cancer: occupational, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Case-Control Studies, cancer epidemiology, business, Case-Control Studie, Psychosocial, Demography, Human
Abstract

BackgroundThe association between socioeconomic disadvantage (low education and/or income) and head and neck cancer is well established, with smoking and alcohol consumption explaining up to three-quarters of the risk. We aimed to investigate the nature of and explanations for head and neck cancer risk associated with occupational socioeconomic prestige (a perceptual measure of psychosocial status), occupational socioeconomic position and manual-work experience, and to assess the potential explanatory role of occupational exposures.MethodsPooled analysis included 5818 patients with head and neck cancer (and 7326 control participants) from five studies in Europe and South America. Lifetime job histories were coded to: (1) occupational social prestige—Treiman’s Standard International Occupational Prestige Scale (SIOPS); (2) occupational socioeconomic position—International Socio-Economic Index (ISEI); and (3) manual/non-manual jobs.ResultsFor the longest held job, adjusting for smoking, alcohol and nature of occupation, increased head and neck cancer risk estimates were observed for low SIOPS OR=1.88 (95% CI: 1.64 to 2.17), low ISEI OR=1.74 (95% CI: 1.51 to 1.99) and manual occupations OR=1.49 (95% CI: 1.35 to 1.64). Following mutual adjustment by socioeconomic exposures, risk associated with low SIOPS remained OR=1.59 (95% CI: 1.30 to 1.94).ConclusionsThese findings indicate that low occupational socioeconomic prestige, position and manual work are associated with head and neck cancer, and such risks are only partly explained by smoking, alcohol and occupational exposures. Perceptual occupational psychosocial status (SIOPS) appears to be the strongest socioeconomic factor, relative to socioeconomic position and manual/non-manual work.

Published
2020

50. Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study

Author

Kai Uwe Saum, Hal Morgenstern, Yun-Chul Hong, Gad Rennert, Nancy Diao, Hidemi Ito, Loic Le Marchand, Ann Olsson, Isabelle Stücker, Walid Saliba, David C. Christiani, Travis J. Meyers, Irene Orlow, Jack Siemiatycki, Anita Koushik, Gord Fehringer, Dario Consonni, Curtis C. Harris, Ann G. Schwartz, Paolo Vineis, Zuo-Feng Zhang, Adonina Tardón, Maria Teresa Landi, Alberto Ruano Raviña, Keitaro Matsuo, John R. McLaughlin, Philip Lazarus, Darren R. Brenner, Eric J. Duell, Paolo Boffetta, Yuan-Chin Amy Lee, Rayjean J. Hung, Kurt Straif, Guillermo Fernández-Tardón, Paul Brennan, Michele L. Cote, Hermann Brenner, Juan Miguel Barros Dios, Angeline S. Andrew, and Brenner, D.R. and Fehringer, G. and Zhang, Z.-F. and Lee, Y.-C.A. and Meyers, T. and Matsuo, K. and Ito, H. and Vineis, P. and Stucker, I. and Boffetta, P. and Brennan, P. and Christiani, D.C. and Diao, N. and Hong, Y.-C. and Landi, M.T. and Morgenstern, H. and Schwartz, A.G. and Rennert, G. and Saliba, W. and McLaughlin, J.R. and Harris, C.C. and Orlow, I. and Barros Dios, J.M. and Ruano Raviña, A. and Siemiatycki, J. and Koushik, A. and Cote, M. and Lazarus, P. and Fernandez-Tardon, G. and Tardon, A. and Le Marchand, L. and Brenner, H. and Saum, K.-U. and Duell, E.J. and Andrew, A.S. and Consonni, D. and Olsson, A. and Hung, R.J. and Straif, K.

Subjects
Male, squamous cell carcinoma, Oncology, Cancer Research, Lung Neoplasms, Epidemiology, cancer risk, Cohort Studies, alcohol, adenocarcinoma, Substance Misuse, Alcohol Use and Health, tobacco consumption, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, middle aged, Odds Ratio, 2.2 Factors relating to the physical environment, 030212 general & internal medicine, Aetiology, Lung, Cancer, Alcoholic Beverages, adult, Hazard ratio, Confounding, drinking behavior, Middle Aged, Stroke, aged, Alcoholism, female, Pooled analysis, priority journal, 030220 oncology & carcinogenesis, Alcoholisme, Public Health and Health Services, Carcinoma, Squamous Cell, Female, beer, Lung cancer, Alcohol, alcoholic beverage, Cohort study, Inverse Association, medicine.medical_specialty, Alcohol Drinking, alcohol consumption, Oncology and Carcinogenesis, cohort analysi, Adenocarcinoma, Article, smoking, 03 medical and health sciences, male, Internal medicine, medicine, Humans, controlled study, Oncology & Carcinogenesis, human, Aged, business.industry, Prevention, questionnaire, Carcinoma, Odds ratio, case control study, medicine.disease, Confidence interval, lung cancer, Good Health and Well Being, Squamous Cell, Case-Control Studies, Càncer de pulmó, business
Abstract

Background There is inadequate evidence to determine whether there is an effect of alcohol consumption on lung cancer risk. We conducted a pooled analysis of data from the International Lung Cancer Consortium and the SYNERGY study to investigate this possible association by type of beverage with adjustment for other potential confounders. Methods Twenty one case-control studies and one cohort study with alcohol-intake data obtained from questionnaires were included in this pooled analysis (19,149 cases and 362,340 controls). Adjusted odds ratios (OR) or hazard ratios (HR) with corresponding 95% confidence intervals (CI) were estimated for each measure of alcohol consumption. Effect estimates were combined using random or fixed-effects models where appropriate. Associations were examined for overall lung cancer and by histological type. Results We observed an inverse association between overall risk of lung cancer and consumption of alcoholic beverages compared to non-drinkers, but the association was not monotonic. The lowest risk was observed for persons who consumed 10–19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12–15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). The association with all lung cancer varied little by type of alcoholic beverage, but there were notable differences for SCC. We observed an association with beer intake (OR for ≥20 g/day vs nondrinker = 1.42; 95% CI: 1.06, 1.90). Conclusions Whether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms.

Published
2019

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