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4. Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Author

Shrine, Nick, Guyatt, Anna L., Erzurumluoglu, A. Mesut, Jackson, Victoria E., Hobbs, Brian D., Melbourne, Carl A., Batini, Chiara, Fawcett, Katherine A., Song, Kijoung, Sakornsakolpat, Phuwanat, Li, Xingnan, Boxall, Ruth, Reeve, Nicola F., Obeidat, Ma’en, Zhao, Jing Hua, Wielscher, Matthias, Weiss, Stefan, Kentistou, Katherine A., Cook, James P., Sun, Benjamin B., Zhou, Jian, Hui, Jennie, Karrasch, Stefan, Imboden, Medea, Harris, Sarah E., Marten, Jonathan, Enroth, Stefan, Kerr, Shona M., Surakka, Ida, Vitart, Veronique, Lehtimäki, Terho, Allen, Richard J., Bakke, Per S., Beaty, Terri H., Bleecker, Eugene R., Bossé, Yohan, Brandsma, Corry-Anke, Chen, Zhengming, Crapo, James D., Danesh, John, DeMeo, Dawn L., Dudbridge, Frank, Ewert, Ralf, Gieger, Christian, Gulsvik, Amund, Hansell, Anna L., Hao, Ke, Hoffman, Joshua D., Hokanson, John E., Homuth, Georg, Joshi, Peter K., Joubert, Philippe, Langenberg, Claudia, Li, Xuan, Li, Liming, Lin, Kuang, Lind, Lars, Locantore, Nicholas, Luan, Jian’an, Mahajan, Anubha, Maranville, Joseph C., Murray, Alison, Nickle, David C., Packer, Richard, Parker, Margaret M., Paynton, Megan L., Porteous, David J., Prokopenko, Dmitry, Qiao, Dandi, Rawal, Rajesh, Runz, Heiko, Sayers, Ian, Sin, Don D., Smith, Blair H., Artigas, María Soler, Sparrow, David, Tal-Singer, Ruth, Timmers, Paul R. H. J., Van den Berge, Maarten, Whittaker, John C., Woodruff, Prescott G., Yerges-Armstrong, Laura M., Troyanskaya, Olga G., Raitakari, Olli T., Kähönen, Mika, Polašek, Ozren, Gyllensten, Ulf, Rudan, Igor, Deary, Ian J., Probst-Hensch, Nicole M., Schulz, Holger, James, Alan L., Wilson, James F., Stubbe, Beate, Zeggini, Eleftheria, Jarvelin, Marjo-Riitta, Wareham, Nick, Silverman, Edwin K., Hayward, Caroline, Morris, Andrew P., Butterworth, Adam S., Scott, Robert A., Walters, Robin G., Meyers, Deborah A., Cho, Michael H., Strachan, David P., Hall, Ian P., Tobin, Martin D., and Wain, Louise V.

Published
2024
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10. Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis

Author

Frenzel, Stefan, Bis, Joshua C, Gudmundsson, Elias F, O’Donnell, Adrienne, Simino, Jeannette, Yaqub, Amber, Bartz, Traci M, Brusselle, Guy GO, Bülow, Robin, DeCarli, Charles S, Ewert, Ralf, Gharib, Sina A, Ghosh, Saptaparni, Gireud-Goss, Monica, Gottesman, Rebecca F, Ikram, M Arfan, Knopman, David S, Launer, Lenore J, London, Stephanie J, Longstreth, WT, Lopez, Oscar L, van Lent, Debora Melo, O’Connor, George, Satizabal, Claudia L, Shrestha, Srishti, Sigurdsson, Sigurdur, Stubbe, Beate, Talluri, Rajesh, Vasan, Ramachandran S, Vernooij, Meike W, Völzke, Henry, Wiggins, Kerri L, Yu, Bing, Beiser, Alexa S, Gudnason, Vilmundur, Mosley, Thomas, Psaty, Bruce M, Wolters, Frank J, Grabe, Hans J, and Seshadri, Sudha

Subjects
Brain Disorders, Lung, Neurosciences, Clinical Research, Aging, Humans, Aged, Forced Expiratory Volume, Cross-Sectional Studies, Magnetic Resonance Imaging, Brain, Dementia, epidemiology, magnetic resonance imaging, respiratory function tests, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

BackgroundPrevious studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.ObjectiveTo study the cross-sectional associations of pulmonary function with structural brain variables.MethodsData from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses.ResultsFEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume.ConclusionIn cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.

Published
2022

11. Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Author

Shrine, Nick, Izquierdo, Abril G., Chen, Jing, Packer, Richard, Hall, Robert J., Guyatt, Anna L., Batini, Chiara, Thompson, Rebecca J., Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D., Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A., John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y., Chen, Zhengming, Li, Liming, Wijnant, Sara R. A., Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G., Manichaikul, Ani, Oelsner, Elizabeth C., Rich, Stephen S., Barr, R. Graham, Kerr, Shona M., Vitart, Veronique, Brown, Michael R., Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M., Gharib, Sina A., Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E., Meyers, Deborah A., Bleecker, Eugene R., Gabriel, Stacey B., Gupta, Namrata, Smith, Albert Vernon, Luan, Jian’an, Zhao, Jing-Hua, Hansen, Ailin F., Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H., Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L., Yu, Bing, Lim, Elise, Xu, Hanfei, O’Connor, George T., Thareja, Gaurav, Albagha, Omar M. E., Suhre, Karsten, Granell, Raquel, Faquih, Tariq O., Hiemstra, Pieter S., Slats, Annelies M., Mullin, Benjamin H., Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T., Wyss, Annah B., Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A., Joshi, Peter K., Timmers, Paul R. H. J., Williams, Alexander T., Free, Robert C., Wang, Xueyang, Morrison, John L., Gilliland, Frank D., Chen, Zhanghua, Wang, Carol A., Foong, Rachel E., Harris, Sarah E., Taylor, Adele, Redmond, Paul, Cook, James P., Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T., Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H., Cox, Simon R., Pennell, Craig E., Hall, Graham L., Gauderman, W. James, Brightling, Chris, Wilson, James F., Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O., Timpson, Nicholas J., Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C., Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L., Dudbridge, Frank, Silverman, Edwin K., Strachan, David P., Walters, Robin G., Morris, Andrew P., London, Stephanie J., Cho, Michael H., Wain, Louise V., Hall, Ian P., and Tobin, Martin D.

Published
2023
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12. Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Author

Shrine, Nick, Izquierdo, Abril G., Chen, Jing, Packer, Richard, Hall, Robert J., Guyatt, Anna L., Batini, Chiara, Thompson, Rebecca J., Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D., Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A., John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y., Chen, Zhengming, Li, Liming, Wijnant, Sara R. A., Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G., Manichaikul, Ani, Oelsner, Elizabeth C., Rich, Stephen S., Barr, R. Graham, Kerr, Shona M., Vitart, Veronique, Brown, Michael R., Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M., Gharib, Sina A., Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E., Meyers, Deborah A., Bleecker, Eugene R., Gabriel, Stacey B., Gupta, Namrata, Smith, Albert Vernon, Luan, Jian’an, Zhao, Jing-Hua, Hansen, Ailin F., Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H., Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L., Yu, Bing, Lim, Elise, Xu, Hanfei, O’Connor, George T., Thareja, Gaurav, Albagha, Omar M. E., Suhre, Karsten, Granell, Raquel, Faquih, Tariq O., Hiemstra, Pieter S., Slats, Annelies M., Mullin, Benjamin H., Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T., Wyss, Annah B., Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A., Joshi, Peter K., Timmers, Paul R. H. J., Williams, Alexander T., Free, Robert C., Wang, Xueyang, Morrison, John L., Gilliland, Frank D., Chen, Zhanghua, Wang, Carol A., Foong, Rachel E., Harris, Sarah E., Taylor, Adele, Redmond, Paul, Cook, James P., Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T., Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H., Cox, Simon R., Pennell, Craig E., Hall, Graham L., Gauderman, W. James, Brightling, Chris, Wilson, James F., Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O., Timpson, Nicholas J., Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C., Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L., Dudbridge, Frank, Silverman, Edwin K., Strachan, David P., Walters, Robin G., Morris, Andrew P., London, Stephanie J., Cho, Michael H., Wain, Louise V., Hall, Ian P., and Tobin, Martin D.

Published
2023
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14. Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea–related Quantitative Trait Locus in Men

Author

Chen, Han, Cade, Brian E, Gleason, Kevin J, Bjonnes, Andrew C, Stilp, Adrienne M, Sofer, Tamar, Conomos, Matthew P, Ancoli-Israel, Sonia, Arens, Raanan, Azarbarzin, Ali, Bell, Graeme I, Below, Jennifer E, Chun, Sung, Evans, Daniel S, Ewert, Ralf, Frazier-Wood, Alexis C, Gharib, Sina A, Haba-Rubio, José, Hagen, Erika W, Heinzer, Raphael, Hillman, David R, Johnson, W Craig, Kutalik, Zoltan, Lane, Jacqueline M, Larkin, Emma K, Lee, Seung Ku, Liang, Jingjing, Loredo, Jose S, Mukherjee, Sutapa, Palmer, Lyle J, Papanicolaou, George J, Penzel, Thomas, Peppard, Paul E, Post, Wendy S, Ramos, Alberto R, Rice, Ken, Rotter, Jerome I, Sands, Scott A, Shah, Neomi A, Shin, Chol, Stone, Katie L, Stubbe, Beate, Sul, Jae Hoon, Tafti, Mehdi, Taylor, Kent D, Teumer, Alexander, Thornton, Timothy A, Tranah, Gregory J, Wang, Chaolong, Wang, Heming, Warby, Simon C, Wellman, D Andrew, Zee, Phyllis C, Hanis, Craig L, Laurie, Cathy C, Gottlieb, Daniel J, Patel, Sanjay R, Zhu, Xiaofeng, Sunyaev, Shamil R, Saxena, Richa, Lin, Xihong, and Redline, Susan

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Genetics, Sleep Research, Clinical Research, Human Genome, Lung, 2.1 Biological and endogenous factors, Aetiology, Adult, Aged, Female, Genome-Wide Association Study, Humans, Male, Middle Aged, Phosphatidylethanolamine N-Methyltransferase, Quantitative Trait Loci, Sex Characteristics, Sleep Apnea, Obstructive, Sleep, REM, Sterol Regulatory Element Binding Protein 1, Trans-Activators, Transcription Factors, ras Proteins, obstructive sleep apnea, genetics, genome-wide association studies, multiethnic, sexual dimorphism, Cardiorespiratory Medicine and Haematology, Respiratory System, Biochemistry and cell biology, Cardiovascular medicine and haematology
Abstract

Obstructive sleep apnea (OSA) is a common heritable disorder displaying marked sexual dimorphism in disease prevalence and progression. Previous genetic association studies have identified a few genetic loci associated with OSA and related quantitative traits, but they have only focused on single ethnic groups, and a large proportion of the heritability remains unexplained. The apnea-hypopnea index (AHI) is a commonly used quantitative measure characterizing OSA severity. Because OSA differs by sex, and the pathophysiology of obstructive events differ in rapid eye movement (REM) and non-REM (NREM) sleep, we hypothesized that additional genetic association signals would be identified by analyzing the NREM/REM-specific AHI and by conducting sex-specific analyses in multiethnic samples. We performed genome-wide association tests for up to 19,733 participants of African, Asian, European, and Hispanic/Latino American ancestry in 7 studies. We identified rs12936587 on chromosome 17 as a possible quantitative trait locus for NREM AHI in men (N = 6,737; P = 1.7 × 10-8) but not in women (P = 0.77). The association with NREM AHI was replicated in a physiological research study (N = 67; P = 0.047). This locus overlapping the RAI1 gene and encompassing genes PEMT1, SREBF1, and RASD1 was previously reported to be associated with coronary artery disease, lipid metabolism, and implicated in Potocki-Lupski syndrome and Smith-Magenis syndrome, which are characterized by abnormal sleep phenotypes. We also identified gene-by-sex interactions in suggestive association regions, suggesting that genetic variants for AHI appear to vary by sex, consistent with the clinical observations of strong sexual dimorphism.

Published
2018

16. Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

Author

Soler Artigas, María, Jackson, Victoria E, Strachan, David P, Hui, Jennie, James, Alan L, Kerr, Shona M, Polasek, Ozren, Vitart, Veronique, Marten, Jonathan, Rudan, Igor, Kähönen, Mika, Surakka, Ida, Gieger, Christian, Karrasch, Stefan, Rawal, Rajesh, Schulz, Holger, Deary, Ian J, Harris, Sarah E, Enroth, Stefan, Gyllensten, Ulf, Imboden, Medea, Probst-Hensch, Nicole M, Lehtimäki, Terho, Raitakari, Olli T, Langenberg, Claudia, Luan, Jian'an, Wareham, Nick, Zhao, Jing Hua, Hayward, Caroline, Murray, Alison, Porteous, David J, Smith, Blair H, Jarvelin, Marjo-Riitta, Wielscher, Matthias, Joshi, Peter K, Kentistou, Katherine A, Timmers, Paul RHJ, Wilson, James F, Cook, James P, Lind, Lars, Mahajan, Anubha, Morris, Andrew P, Ewert, Ralf, Homuth, Georg, Stubbe, Beate, Weiss, Stefan, Zeggini, Eleftheria, Moll, Matthew, Sakornsakolpat, Phuwanat, Shrine, Nick, Hobbs, Brian D, DeMeo, Dawn L, John, Catherine, Guyatt, Anna L, McGeachie, Michael J, Gharib, Sina A, Obeidat, Ma'en, Lahousse, Lies, Wijnant, Sara R A, Brusselle, Guy, Meyers, Deborah A, Bleecker, Eugene R, Li, Xingnan, Tal-Singer, Ruth, Manichaikul, Ani, Rich, Stephen S, Won, Sungho, Kim, Woo Jin, Do, Ah Ra, Washko, George R, Barr, R Graham, Psaty, Bruce M, Bartz, Traci M, Hansel, Nadia N, Barnes, Kathleen, Hokanson, John E, Crapo, James D, Lynch, David, Bakke, Per, Gulsvik, Amund, Hall, Ian P, Wain, Louise, Weiss, Scott T, Silverman, Edwin K, Dudbridge, Frank, Tobin, Martin D, and Cho, Michael H

Published
2020
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18. Cardiopulmonary exercise testing and the 2022 definition of pulmonary hypertension.

Author

Habedank, Dirk, Ittermann, Till, Kaczmarek, Sabine, Stubbe, Beate, Heine, Alexander, Obst, Anne, and Ewert, Ralf

Subjects
EXERCISE tests, PULMONARY hypertension, HYPERTENSION, DEFINITIONS
Abstract

Parameters of cardiopulmonary exercise testing significantly discriminate between healthy subjects and patients with pulmonary hypertension (PH), also according to the new 2022 definition of pulmonary hypertension (mean pulmonary arterial pressure mPAP > 20 mmHg). The cut‐offs indicating on PH were peakVO2 ≤ 16.7 mL/min/kg (Youden‐Index YI = 0.79), petCO2@AT ≤ 34 mmHg (YI = 0.67), and VE/VCO2@AT ≤ 30 (YI = 0.76). [ABSTRACT FROM AUTHOR]

Published
2024
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19. Sleep characteristics and parameters of bone turnover and strength in the adult population: results from the Study of Health in Pomerania‐TREND.

Author

Rassow, Kathrin, Obst, Anne, Nauck, Matthias, Völzke, Henry, Stubbe, Beate, Fietze, Ingo, Penzel, Thomas, Ewert, Ralf, and Hannemann, Anke

Subjects
BONE remodeling, SLEEP duration, SLEEP quality, BONE health, BONE density, SLEEP, SLEEP hygiene
Abstract

Summary: Poor sleep quality or sleep deprivation may be related to decreased bone mineral density. We aimed to assess whether associations of sleep characteristics and bone turnover or strength are present in adults from the general population and whether these are independent of common risk factors such as sex, age, and obesity. A total of 1037 participants from the Study of Health in Pomerania‐TREND underwent laboratory‐based polysomnography and quantitative ultrasound measurements at the heel. Of these participants, 804 completed standardised questionnaires to assess daytime sleepiness, insomnia, and sleep quality. Serum concentrations of two bone turnover markers, intact amino‐terminal propeptide of type 1 procollagen (P1NP) and carboxy‐terminal telopeptide of type 1 collagen (CTX) were measured. Cross‐sectional associations of polysomnography variables (total sleep time, sleep efficiency, time spent wake after sleep onset, oxygen desaturation index, apnea–hypopnea index, and obstructive sleep apnea [OSA]), as well as sleep questionnaire scores with the bone turnover markers and the ultrasound‐based stiffness index were assessed in linear regression models. In adjusted models, higher insomnia scores and lower sleep quality scores were related to a higher bone turnover in women but not in men. However, associations between polysomnography variables or questionnaire scores and the stiffness index were absent. Our study provides limited evidence for relationships between sleep characteristics and bone turnover and strength independent of common risk factors for OSA and osteoporosis. Nevertheless, women reporting poor sleep or insomnia in combination with risk factors for osteoporosis might benefit from an evaluation of bone health. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Association of spermidine blood levels with microstructure of sleep—implications from a population-based study

Author

Wortha, Silke M., primary, Schulz, Juliane, additional, Hanna, Jevri, additional, Schwarz, Claudia, additional, Stubbe, Beate, additional, Frenzel, Stefan, additional, Bülow, Robin, additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Völzke, Henry, additional, Ewert, Ralf, additional, Vogelgesang, Antje, additional, Grabe, Hans J., additional, Ladenbauer, Julia, additional, and Flöel, Agnes, additional

Published
2023
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22. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Author

Shrine, Nick, Guyatt, Anna L., Erzurumluoglu, A. Mesut, Jackson, Victoria E., Hobbs, Brian D., Melbourne, Carl A., Batini, Chiara, Fawcett, Katherine A., Song, Kijoung, Sakornsakolpat, Phuwanat, Li, Xingnan, Boxall, Ruth, Reeve, Nicola F., Obeidat, Ma’en, Zhao, Jing Hua, Wielscher, Matthias, Weiss, Stefan, Kentistou, Katherine A., Cook, James P., Sun, Benjamin B., Zhou, Jian, Hui, Jennie, Karrasch, Stefan, Imboden, Medea, Harris, Sarah E, Marten, Jonathan, Enroth, Stefan, Kerr, Shona M., Surakka, Ida, Vitart, Veronique, Lehtimäki, Terho, Allen, Richard J., Bakke, Per S., Beaty, Terri H., Bleecker, Eugene R., Bossé, Yohan, Brandsma, Corry-Anke, Chen, Zhengming, Crapo, James D., Danesh, John, DeMeo, Dawn L., Dudbridge, Frank, Ewert, Ralf, Gieger, Christian, Gulsvik, Amund, Hansell, Anna L., Hao, Ke, Hoffman, Joshua D., Hokanson, John E., Homuth, Georg, Joshi, Peter K., Joubert, Philippe, Langenberg, Claudia, Li, Xuan, Li, Liming, Lin, Kuang, Lind, Lars, Locantore, Nicholas, Luan, Jian’an, Mahajan, Anubha, Maranville, Joseph C., Murray, Alison, Nickle, David C., Packer, Richard, Parker, Margaret M., Paynton, Megan L., Porteous, David J., Prokopenko, Dmitry, Qiao, Dandi, Rawal, Rajesh, Runz, Heiko, Sayers, Ian, Sin, Don D, Smith, Blair H, Soler Artigas, María, Sparrow, David, Tal-Singer, Ruth, Timmers, Paul R. H. J., Van den Berge, Maarten, Whittaker, John C., Woodruff, Prescott G., Yerges-Armstrong, Laura M., Troyanskaya, Olga G., Raitakari, Olli T., Kähönen, Mika, Polašek, Ozren, Gyllensten, Ulf, Rudan, Igor, Deary, Ian J., Probst-Hensch, Nicole M., Schulz, Holger, James, Alan L, Wilson, James F., Stubbe, Beate, Zeggini, Eleftheria, Jarvelin, Marjo-Riitta, Wareham, Nick, Silverman, Edwin K., Hayward, Caroline, Morris, Andrew P., Butterworth, Adam S., Scott, Robert A., Walters, Robin G., Meyers, Deborah A., Cho, Michael H., Strachan, David P., Hall, Ian P., Tobin, Martin D., and Wain, Louise V.

Published
2019
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24. Evaluating heart rate variability with 10 second multichannel electrocardiograms in a large population-based sample

Author

Krause, Elischa, primary, Vollmer, Marcus, additional, Wittfeld, Katharina, additional, Weihs, Antoine, additional, Frenzel, Stefan, additional, Dörr, Marcus, additional, Kaderali, Lars, additional, Felix, Stephan B., additional, Stubbe, Beate, additional, Ewert, Ralf, additional, Völzke, Henry, additional, and Grabe, Hans J., additional

Published
2023
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27. Lack of structural brain alterations associated with insomnia: findings from the ENIGMA‐Sleep Working Group.

Author

Weihs, Antoine, Frenzel, Stefan, Bi, Hanwen, Schiel, Julian E., Afshani, Mortaza, Bülow, Robin, Ewert, Ralf, Fietze, Ingo, Hoffstaedter, Felix, Jahanshad, Neda, Khazaie, Habibolah, Riemann, Dieter, Rostampour, Masoumeh, Stubbe, Beate, Thomopoulos, Sophia I., Thompson, Paul M., Valk, Sofie L., Völzke, Henry, Zarei, Mojtaba, and Eickhoff, Simon B.

Abstract

Summary: Existing neuroimaging studies have reported divergent structural alterations in insomnia disorder (ID). In the present study, we performed a large‐scale coordinated meta‐analysis by pooling structural brain measures from 1085 subjects (mean [SD] age 50.5 [13.9] years, 50.2% female, 17.4% with insomnia) across three international Enhancing NeuroImaging Genetics through Meta‐Analysis (ENIGMA)‐Sleep cohorts. Two sites recruited patients with ID/controls: Freiburg (University of Freiburg Medical Center, Freiburg, Germany) 42/43 and KUMS (Kermanshah University of Medical Sciences, Kermanshah, Iran) 42/49, while the Study of Health in Pomerania (SHIP‐Trend, University Medicine Greifswald, Greifswald, Germany) recruited population‐based individuals with/without insomnia symptoms 75/662. The influence of insomnia on magnetic resonance imaging‐based brain morphometry using an insomnia brain score was then assessed. Within each cohort, we used an ordinary least‐squares linear regression to investigate the link between the individual regional cortical and subcortical volumes and the presence of insomnia symptoms. Then, we performed a fixed‐effects meta‐analysis across cohorts based on the first‐level results. For the insomnia brain score, weighted logistic ridge regression was performed on one sample (Freiburg), which separated patients with ID from controls to train a model based on the segmentation measurements. Afterward, the insomnia brain scores were validated using the other two samples. The model was used to predict the log‐odds of the subjects with insomnia given individual insomnia‐related brain atrophy. After adjusting for multiple comparisons, we did not detect any significant associations between insomnia symptoms and cortical or subcortical volumes, nor could we identify a global insomnia‐related brain atrophy pattern. Thus, we observed inconsistent brain morphology differences between individuals with and without insomnia across three independent cohorts. Further large‐scale cross‐sectional/longitudinal studies using both structural and functional neuroimaging are warranted to decipher the neurobiology of insomnia. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Molecular mechanisms underlying variations in lung function: a systems genetics analysis

Author

Obeidat, Ma'en, Hao, Ke, Bossé, Yohan, Nickle, David C, Nie, Yunlong, Postma, Dirkje S, Laviolette, Michel, Sandford, Andrew J, Daley, Denise D, Hogg, James C, Elliott, W Mark, Fishbane, Nick, Timens, Wim, Hysi, Pirro G, Kaprio, Jaakko, Wilson, James F, Hui, Jennie, Rawal, Rajesh, Schulz, Holger, Stubbe, Beate, Hayward, Caroline, Polasek, Ozren, Järvelin, Marjo-Riitta, Zhao, Jing Hua, Jarvis, Deborah, Kähönen, Mika, Franceschini, Nora, North, Kari E, Loth, Daan W, Brusselle, Guy G, Smith, Albert Vernon, Gudnason, Vilmundur, Bartz, Traci M, Wilk, Jemma B, O'Connor, George T, Cassano, Patricia A, Tang, Wenbo, Wain, Louise V, Artigas, María Soler, Gharib, Sina A, Strachan, David P, Sin, Don D, Tobin, Martin D, London, Stephanie J, Hall, Ian P, and Paré, Peter D

Published
2015
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29. Do brachycephaly and nose size predict the severity of obstructive sleep apnea (OSA)? A sample‐based geometric morphometric analysis of craniofacial variation in relation to OSA syndrome and the role of confounding factors

Author

Daboul, Amro, primary, Krüger, Markus, additional, Ivanovska, Tatyana, additional, Obst, Anne, additional, Ewert, Ralf, additional, Stubbe, Beate, additional, Fietze, Ingo, additional, Penzel, Thomas, additional, Hosten, Norbert, additional, Biffar, Reiner, additional, and Cardini, Andrea, additional

Published
2022
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30. Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment

Author

Kahnert, Kathrin, Andreas, Stefan, Kellerer, Christina, Lutter, Johanna I., Lucke, Tanja, Yildirim, Önder, Lehmann, Mareike, Seissler, Jochen, Behr, Jürgen, Frankenberger, Marion, Bals, Robert, Watz, Henrik, Welte, Tobias, Trudzinski, Franziska C., Vogelmeier, Claus F., Alter, Peter, Jörres, Rudolf A., Bahmer, Thomas, Bewig, Burkhard, Ewert, Ralf, Stubbe, Beate, Ficker, Joachim H., Grohé, Christian, Held, Matthias, Henke, Markus, Herth, Felix, Kirsten, Anne-Marie, Koczulla, Rembert, Kronsbein, Juliane, Kropf-Sanchen, Cornelia, Herzmann, Christian, Pfeifer, Michael, Randerath, Winfried J., Seeger, Werner, Studnicka, Michael, Taube, Christian, Timmermann, Hartmut, Schmeck, Bernd, Vogelmeier, Claus, and Wirtz, Hubert

Subjects
Male, Epidemiology, Science, Vital Capacity, Medizin, Article, Body Mass Index, Cohort Studies, Pulmonary Disease, Chronic Obstructive, Sex Factors, Forced Expiratory Volume, Diabetes Mellitus, Humans, Hypoglycemic Agents, Lung, Aged, Multidisciplinary, Smoking, Age Factors, Middle Aged, respiratory system, Metformin, respiratory tract diseases, Pulmonary Emphysema, Pulmonary Diffusing Capacity, Medicine, Female, Drug therapy
Abstract

We studied whether in patients with COPD the use of metformin for diabetes treatment was linked to a pattern of lung function decline consistent with the hypothesis of anti-aging effects of metformin. Patients of GOLD grades 1–4 of the COSYCONET cohort with follow-up data of up to 4.5 y were included. The annual decline in lung function (FEV1, FVC) and CO diffusing capacity (KCO, TLCO) in %predicted at baseline was evaluated for associations with age, sex, BMI, pack-years, smoking status, baseline lung function, exacerbation risk, respiratory symptoms, cardiac disease, as well as metformin-containing therapy compared to patients without diabetes and metformin. Among 2741 patients, 1541 (mean age 64.4 y, 601 female) fulfilled the inclusion criteria. In the group with metformin treatment vs. non-diabetes the mean annual decline in KCO and TLCO was significantly lower (0.2 vs 2.3, 0.8 vs. 2.8%predicted, respectively; p 1 and FVC. These results were confirmed using multiple regression and propensity score analyses. Our findings demonstrate an association between the annual decline of lung diffusing capacity and the intake of metformin in patients with COPD consistent with the hypothesis of anti-aging effects of metformin as reflected in a surrogate marker of emphysema.

Published
2022

31. Lack of Structural Brain Alterations associated with Insomnia: Findings from the ENIGMA-Sleep working group

Author

Weihs, Antoine, primary, Frenzel, Stefan, additional, Bi, Hanwen, additional, Schiel, Julian, additional, Afshani, Mortaza, additional, Bülow, Robin, additional, Ewert, Ralf, additional, Fietze, Ingo, additional, Hoffstaedter, Felix, additional, Jahanshad, Neda, additional, Khazaie, Habibolah, additional, Riemann, Dieter, additional, Rostampour, Masoumeh, additional, Stubbe, Beate, additional, Thomopoulos, Sophia, additional, Thompson, Paul, additional, Valk, Sofie, additional, Völzke, Henry, additional, Zarei, Mojtaba, additional, Eickhoff, Simon, additional, Grabe, Hans, additional, Patil, Kaustubh, additional, Spiegelhalder, Kai, additional, and Tahmasian, Masoud, additional

Published
2022
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32. Prognostic Relevance of Cardiopulmonary Exercise Testing for Patients with Chronic Thromboembolic Pulmonary Hypertension

Author

Ewert, Ralf, primary, Ittermann, Till, additional, Schmitt, Delia, additional, Pfeuffer-Jovic, Elena, additional, Stucke, Johannes, additional, Tausche, Kristin, additional, Halank, Michael, additional, Winkler, Jörg, additional, Hoheisel, Andreas, additional, Stubbe, Beate, additional, Heine, Alexander, additional, Seyfarth, Hans-Jürgen, additional, Opitz, Christian, additional, Habedank, Dirk, additional, Wensel, Roland, additional, and Held, Matthias, additional

Published
2022
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33. Do brachycephaly and nose size predict the severity of obstructive sleep apnea (OSA)? A sample‐based geometric morphometric analysis of craniofacial variation in relation to OSA syndrome and the role of confounding factors.

Author

Daboul, Amro, Krüger, Markus, Ivanonvka, Tatyana, Obst, Anne, Ewert, Ralf, Stubbe, Beate, Fietze, Ingo, Penzel, Thomas, Hosten, Norbert, Biffar, Reiner, and Cardini, Andrea

Subjects
SLEEP apnea syndromes, GEOMETRIC analysis, SOMNOLOGY, BRACHYCEPHALY, NOSE, SYNDROMES, MORPHOMETRICS
Abstract

Summary: Obstructive sleep apnea is a common disorder that leads to sleep fragmentation and is potentially bidirectionally related to a variety of comorbidities, including an increased risk of heart failure and stroke. It is often considered a consequence of anatomical abnormalities, especially in the head and neck, but its pathophysiology is likely to be multifactorial in origin. With geometric morphometrics, and a large sample of adults from the Study for Health in Pomerania, we explore the association of craniofacial morphology to the apnea–hypopnea index used as an estimate of obstructive sleep apnea severity. We show that craniofacial size and asymmetry, an aspect of morphological variation seldom analysed in obstructive sleep apnea research, are both uncorrelated to apnea–hypopnea index. In contrast, as in previous analyses, we find evidence that brachycephaly and larger nasal proportions might be associated to obstructive sleep apnea severity. However, this correlational signal is weak and completely disappears when age‐related shape variation is statistically controlled for. Our findings suggest that previous work might need to be re‐evaluated, and urge researchers to take into account the role of confounders to avoid potentially spurious findings in association studies. [ABSTRACT FROM AUTHOR]

Published
2023
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34. The association of cognitive functioning as measured by the DemTect with functional and clinical characteristics of COPD: results from the COSYCONET cohort

Author

von Siemens, Sarah Marietta, Perneczky, Robert, Waschki, Benjamin, Lutter, Johanna I, Welte, Tobias, Jörres, Rudolf A, Kahnert, Kathrin, group, COSYCONET study, Andreas, Stefan, Bals, Robert, Behr, Jürgen, Vogelmeier, Claus F, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Gogol, Manfred, Grohé, Christian, Hauck, Rainer, Held, Matthias, Jany, Berthold, Henke, Markus, Herth, Felix, Höffken, Gerd, Katus, Hugo A, Kirsten, Anne-Marie, Watz, Henrik, Koczulla, Rembert, Kenn, Klaus, Kronsbein, Juliane, Kropf-Sanchen, Cornelia, Lange, Christoph, Kauffmann-Guerrero, Diego, Zabel, Peter, Pfeifer, Michael, Randerath, Winfried J, Seeger, Werner, Studnicka, Michael, Taube, Christian, Teschler, Helmut, Timmermann, Hartmut, Virchow, J Christian, Vogelmeier, Claus, Alter, Peter, Wagner, Ulrich, Wirtz, Hubert, Trudzinski, Franziska C, and Söhler, Sandra

Subjects
Male, medicine.medical_specialty, epidemiology [Cognitive Dysfunction], psychology [Pulmonary Disease, Chronic Obstructive], Medizin, Comorbidity, Cohort Studies, 03 medical and health sciences, FEV1/FVC ratio, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Cognition, epidemiology [Pulmonary Disease, Chronic Obstructive], Surveys and Questionnaires, medicine, Dementia, Humans, COPD, Cognitive Dysfunction, ddc:610, Cognitive skill, Path analysis (statistics), Aged, lcsh:RC705-779, business.industry, Research, physiology [Cognition], diagnosis [Pulmonary Disease, Chronic Obstructive], lcsh:Diseases of the respiratory system, Middle Aged, medicine.disease, Mental Status and Dementia Tests, humanities, Cross-Sectional Studies, Cognitive impairment, diagnosis [Cognitive Dysfunction], 030228 respiratory system, Cohort, Physical therapy, Female, psychology [Cognitive Dysfunction], business, 030217 neurology & neurosurgery, Cognitive load
Abstract

Alterations of cognitive functions have been described in COPD. Our study aimed to disentangle the relationship between the degree of cognitive function and COPD characteristics including quality of life (QoL).Data from 1969 COPD patients of the COSYCONET cohort (GOLD grades 1–4; 1216 male/ 753 female; mean (SD) age 64.9 ± 8.4 years) were analysed using regression and path analysis. The DemTect screening tool was used to measure cognitive function, and the St. George‘s respiratory questionnaire (SGRQ) to assess disease-specific QoL.DemTect scores were =60 years of age. For statistical reasons, we used the average of both algorithms independent of age in all subsequent analyses. The DemTect scores were associated with oxygen content, 6-min-walking distance (6-MWD), C-reactive protein (CRP), modified Medical Research Council dyspnoea scale (mMRC) and the SGRQ impact score. Conversely, the SGRQ impact score was independently associated with 6-MWD, FVC, mMRC and DemTect. These results were combined into a path analysis model to account for direct and indirect effects. The DemTect score had a small, but independent impact on QoL, irrespective of the inclusion of COPD-specific influencing factors or a diagnosis of cognitive impairment.We conclude that in patients with stable COPD lower oxygen content of blood as a measure of peripheral oxygen supply, lower exercise capacity in terms of 6-MWD, and higher CRP levels were associated with reduced cognitive capacity. Furthermore, a reduction in cognitive capacity was associated with reduced disease-specific quality of life. As a potential clinical implication of this work, we suggest to screen especially patients with low oxygen content and low 6-MWD for cognitive impairment.

Published
2022
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36. Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

Author

Shrine, Nick, primary, Izquierdo, Abril G, additional, Chen, Jing, additional, Packer, Richard, additional, Hall, Robert J, additional, Guyatt, Anna L, additional, Batini, Chiara, additional, Thompson, Rebecca J, additional, Pavuluri, Chandan, additional, Malik, Vidhi, additional, Hobbs, Brian D, additional, Moll, Matthew, additional, Kim, Wonji, additional, Tal-Singer, Ruth, additional, Bakke, Per, additional, Fawcett, Katherine A, additional, John, Catherine, additional, Coley, Kayesha, additional, Piga, Noemi Nicole, additional, Pozarickij, Alfred, additional, Lin, Kuang, additional, Millwood, Iona Y, additional, Chen, Zhengming, additional, Li, Liming, additional, Wielscher, Sara RA, additional, Lahousse, Lies, additional, Brusselle, Guy, additional, Uitterlinden, Andre G, additional, Manichaikul, Ani, additional, Oelsner, Elizabeth C, additional, Rich, Stephen S, additional, Barr, R. Graham, additional, Kerr, Shona M, additional, Vitart, Veronique, additional, Brown, Michael R, additional, Wielscher, Matthias, additional, Imboden, Medea, additional, Jeong, Ayoung, additional, Bartz, Traci M, additional, Gharib, Sina A, additional, Flexeder, Claudia, additional, Karrasch, Stefan, additional, Gieger, Christian, additional, Peters, Annette, additional, Stubbe, Beate, additional, Hu, Xiaowei, additional, Ortega, Victor E, additional, Meyers, Deborah A, additional, Bleecker, Eugene R, additional, Gabriel, Stacey B, additional, Gupta, Namrata, additional, Smith, Albert Vernon, additional, Luan, Jian’an, additional, Zhao, Jing-Hua, additional, Hansen, Ailin F, additional, Langhammer, Arnulf, additional, Willer, Cristen, additional, Bhatta, Laxmi, additional, Porteous, David, additional, Smith, Blair H, additional, Campbell, Archie, additional, Sofer, Tamar, additional, Lee, Jiwon, additional, Daviglus, Martha L, additional, Yu, Bing, additional, Lim, Elise, additional, Xu, Hanfei, additional, O’Connor, George T, additional, Thareja, Gaurav, additional, E., Omar M, additional, Mbarek, Hamdi, additional, Suhre, Karsten, additional, Granell, Raquel, additional, Faquih, Tariq O, additional, Hiemstra, Pieter S, additional, Slats, Annelies M, additional, Mullin, Benjamin H, additional, Hui, Jennie, additional, James, Alan, additional, Beilby, John, additional, Patasova, Karina, additional, Hysi, Pirro, additional, Koskela, Jukka T, additional, Wyss, Annah B, additional, Jin, Jianping, additional, Sikdar, Sinjini, additional, Lee, Mikyeong, additional, May-Wilson, Sebastian, additional, Pirastu, Nicola, additional, Kentistou, Katherine A, additional, Joshi, Peter K, additional, Timmers, Paul RHJ, additional, Williams, Alexander T, additional, Free, Robert C, additional, Wang, Xueyang, additional, Morrison, John L, additional, Gilliland, Frank D, additional, Chen, Zhanghua, additional, Wang, Carol A, additional, Foong, Rachel E, additional, Harris, Sarah E, additional, Taylor, Adele, additional, Redmond, Paul, additional, Cook, James P, additional, Mahajan, Anubha, additional, Lind, Lars, additional, Palviainen, Teemu, additional, Lehtimäki, Terho, additional, Raitakari, Olli T, additional, Kaprio, Jaakko, additional, Rantanen, Taina, additional, Pietiläinen, Kirsi H, additional, Cox, Simon R, additional, Pennell, Craig E, additional, Hall, Graham L, additional, Gauderman, W. James, additional, Brightling, Chris, additional, Wilson, James F, additional, Vasankari, Tuula, additional, Laitinen, Tarja, additional, Salomaa, Veikko, additional, Mook-Kanamori, Dennis O, additional, Timpson, Nicholas J, additional, Zeggini, Eleftheria, additional, Dupuis, Josée, additional, Hayward, Caroline, additional, Brumpton, Ben, additional, Langenberg, Claudia, additional, Weiss, Stefan, additional, Homuth, Georg, additional, Schmidt, Carsten Oliver, additional, Probst-Hensch, Nicole, additional, Jarvelin, Marjo-Riitta, additional, Morrison, Alanna C, additional, Polasek, Ozren, additional, Rudan, Igor, additional, Lee, Joo-Hyeon, additional, Sayers, Ian, additional, Rawlins, Emma L, additional, Dudbridge, Frank, additional, Silverman, Edwin K, additional, Strachan, David P, additional, Walters, Robin G, additional, Morris, Andrew P, additional, London, Stephanie J, additional, Cho, Michael H, additional, Wain, Louise V, additional, Hall, Ian P, additional, and Tobin, Martin D, additional

Published
2022
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37. Associations of Pulmonary Function with MRI Brain Volumes:A Coordinated Multi-Study Analysis

Author

Frenzel, Stefan, Bis, Joshua C., Gudmundsson, Elias F., O'Donnell, Adrienne, Simino, Jeannette, Yaqub, Amber, Bartz, Traci M., Brusselle, Guy G.O., Bülow, Robin, DeCarli, Charles S., Ewert, Ralf, Gharib, Sina A., Ghosh, Saptaparni, Gireud-Goss, Monica, Gottesman, Rebecca F., Ikram, M. Arfan, Knopman, David S., Launer, Lenore J., London, Stephanie J., Longstreth, W. T., Lopez, Oscar L., Melo van Lent, Debora, O'Connor, George, Satizabal, Claudia L., Shrestha, Srishti, Sigurdsson, Sigurdur, Stubbe, Beate, Talluri, Rajesh, Vasan, Ramachandran S., Vernooij, Meike W., Völzke, Henry, Wiggins, Kerri L., Yu, Bing, Beiser, Alexa S., Gudnason, Vilmundur, Mosley, Thomas, Psaty, Bruce M., Wolters, Frank J., Grabe, Hans J., Seshadri, Sudha, Frenzel, Stefan, Bis, Joshua C., Gudmundsson, Elias F., O'Donnell, Adrienne, Simino, Jeannette, Yaqub, Amber, Bartz, Traci M., Brusselle, Guy G.O., Bülow, Robin, DeCarli, Charles S., Ewert, Ralf, Gharib, Sina A., Ghosh, Saptaparni, Gireud-Goss, Monica, Gottesman, Rebecca F., Ikram, M. Arfan, Knopman, David S., Launer, Lenore J., London, Stephanie J., Longstreth, W. T., Lopez, Oscar L., Melo van Lent, Debora, O'Connor, George, Satizabal, Claudia L., Shrestha, Srishti, Sigurdsson, Sigurdur, Stubbe, Beate, Talluri, Rajesh, Vasan, Ramachandran S., Vernooij, Meike W., Völzke, Henry, Wiggins, Kerri L., Yu, Bing, Beiser, Alexa S., Gudnason, Vilmundur, Mosley, Thomas, Psaty, Bruce M., Wolters, Frank J., Grabe, Hans J., and Seshadri, Sudha

Abstract

BACKGROUND: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent. OBJECTIVE: To study the cross-sectional associations of pulmonary function with structural brain variables. METHODS: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses. RESULTS: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume. CONCLUSION: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.

Published
2022

38. Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Author

Shrine, Nick, Guyatt, Anna L., Erzurumluoglu, A. Mesut, Jackson, Victoria E., Hobbs, Brian D., Melbourne, Carl A., Batini, Chiara, Fawcett, Katherine A., Song, Kijoung, Sakornsakolpat, Phuwanat, Li, Xingnan, Boxall, Ruth, Reeve, Nicola F., Obeidat, Ma’en, Zhao, Jing Hua, Wielscher, Matthias, Weiss, Stefan, Kentistou, Katherine A., Cook, James P., Sun, Benjamin B., Zhou, Jian, Hui, Jennie, Karrasch, Stefan, Imboden, Medea, Harris, Sarah E, Marten, Jonathan, Enroth, Stefan, Kerr, Shona M., Surakka, Ida, Vitart, Veronique, Lehtimäki, Terho, Allen, Richard J., Bakke, Per S., Beaty, Terri H., Bleecker, Eugene R., Bossé, Yohan, Brandsma, Corry-Anke, Chen, Zhengming, Crapo, James D., Danesh, John, DeMeo, Dawn L., Dudbridge, Frank, Ewert, Ralf, Gieger, Christian, Gulsvik, Amund, Hansell, Anna L., Hao, Ke, Hoffman, Joshua D., Hokanson, John E., Homuth, Georg, Joshi, Peter K., Joubert, Philippe, Langenberg, Claudia, Li, Xuan, Li, Liming, Lin, Kuang, Lind, Lars, Locantore, Nicholas, Luan, Jian’an, Mahajan, Anubha, Maranville, Joseph C., Murray, Alison, Nickle, David C., Packer, Richard, Parker, Margaret M., Paynton, Megan L., Porteous, David J., Prokopenko, Dmitry, Qiao, Dandi, Rawal, Rajesh, Runz, Heiko, Sayers, Ian, Sin, Don D, Smith, Blair H, Artigas, María Soler, Sparrow, David, Tal-Singer, Ruth, Timmers, Paul R. H. J., Van den Berge, Maarten, Whittaker, John C., Woodruff, Prescott G., Yerges-Armstrong, Laura M., Troyanskaya, Olga G., Raitakari, Olli T., Kähönen, Mika, Polašek, Ozren, Gyllensten, Ulf, Rudan, Igor, Deary, Ian J., Probst-Hensch, Nicole M., Schulz, Holger, James, Alan L, Wilson, James F., Stubbe, Beate, Zeggini, Eleftheria, Jarvelin, Marjo-Riitta, Wareham, Nick, Silverman, Edwin K., Hayward, Caroline, Morris, Andrew P., Butterworth, Adam S., Scott, Robert A., Walters, Robin G., Meyers, Deborah A., Cho, Michael H., Strachan, David P., Hall, Ian P., Tobin, Martin D., and Wain, Louise V.

Published
2019
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42. Cohort Profile Update: The Study of Health in Pomerania (SHIP)

Author

Völzke, Henry, primary, Schössow, Janka, additional, Schmidt, Carsten Oliver, additional, Jürgens, Clemens, additional, Richter, Adrian, additional, Werner, André, additional, Werner, Nicole, additional, Radke, Dörte, additional, Teumer, Alexander, additional, Ittermann, Till, additional, Schauer, Birgit, additional, Henck, Vivien, additional, Friedrich, Nele, additional, Hannemann, Anke, additional, Winter, Theresa, additional, Nauck, Matthias, additional, Dörr, Marcus, additional, Bahls, Martin, additional, Felix, Stephan B, additional, Stubbe, Beate, additional, Ewert, Ralf, additional, Frost, Fabian, additional, Lerch, Markus M, additional, Grabe, Hans J, additional, Bülow, Robin, additional, Otto, Markus, additional, Hosten, Norbert, additional, Rathmann, Wolfgang, additional, Schminke, Ulf, additional, Großjohann, Rico, additional, Tost, Frank, additional, Homuth, Georg, additional, Völker, Uwe, additional, Weiss, Stefan, additional, Holtfreter, Silva, additional, Bröker, Barbara M, additional, Zimmermann, Kathrin, additional, Kaderali, Lars, additional, Winnefeld, Marc, additional, Kristof, Boris, additional, Berger, Klaus, additional, Samietz, Stefanie, additional, Schwahn, Christian, additional, Holtfreter, Birte, additional, Biffar, Reiner, additional, Kindler, Stefan, additional, Wittfeld, Katharina, additional, Hoffmann, Wolfgang, additional, and Kocher, Thomas, additional

Published
2022
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44. Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET

Author

Trudzinski, F.C., Jörres, R.A., Alter, P., Kahnert, K., Waschki, B., Herr, C., Kellerer, C., Omlor, A., Vogelmeier, C.F., Fähndrich, S., Watz, H., Welte, T., Jany, B., Söhler, S., Biertz, F., Herth, F., Kauczor, H.-U., Bals, R., Andreas, Stefan, Behr, Jürgen, Bewig, Burkhard, Buhl, Roland, Ewert, Ralf, Stubbe, Beate, Ficker, Joachim H., Gogol, Manfred, Grohé, Christian, Hauck, Rainer, Held, Matthias, Henke, Markus, Höffken, Gerd, Katus, Hugo A., Kirsten, Anne-Marie, Koczulla, Rembert, Kenn, Klaus, Kronsbein, Juliane, Kropf-Sanchen, Lange, Christoph, Zabel, Peter, Pfeifer, Michael, Randerath, Winfried J., Seeger, Werner, Studnicka, Michael, Taube, Christian, Teschler, Helmut, Timmermann, Hartmut, Virchow, J. Christian, Wagner, and Wirtz, Hubert

Subjects
Adult, Male, medicine.medical_specialty, Exacerbation, Medizin, lcsh:Medicine, Severity of Illness Index, Gastroenterology, Article, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, Medical research, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Signs and symptoms, lcsh:Science, Survival rate, Aged, Oxygen saturation (medicine), Aged, 80 and over, Inflammation, COPD, Oxygenated Hemoglobin, Multidisciplinary, Proportional hazards model, business.industry, Hazard ratio, lcsh:R, Middle Aged, Prognosis, medicine.disease, Comorbidity, Survival Rate, Risk factors, 030228 respiratory system, Oxyhemoglobins, Female, lcsh:Q, Blood Gas Analysis, business, Biomarkers
Abstract

We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1–4) of the baseline dataset of the COSYCONET COPD cohort were used. The associations with dyspnea, exacerbation history, BODE-Index (cut-off ≤2) and all-cause mortality over 3 years of follow-up were determined by logistic and Cox regression analyses, with sex, age, BMI and pack years as covariates. Predictive values were evaluated by ROC curves. Capillary blood gases included SaO2, PaO2, PaCO2, pH, BE and the concentration of OxyHem [haemoglobin (Hb) x fractional SaO2, g/dL] as a simple-to-measure correlate of oxygen content. Inflammatory markers were WBC, CRP, IL-6 and -8, TNF-alpha and fibrinogen, and comorbidities comprised a broad panel including cardiac and metabolic disorders. Among BG, OxyHem was associated with dyspnoea, exacerbation history, BODE-Index and mortality. Among inflammatory markers and comorbidities, only WBC and heart failure were consistently related to all outcomes. ROC analyses indicated that OxyHem provided information of a magnitude comparable to that of WBC, with optimal cut-off values of 12.5 g/dL and 8000/µL, respectively. Regarding mortality, OxyHem also carried independent, additional information, showing a hazard ratio of 2.77 (95% CI: 1.85–4.15, p 8000/µL was 2.33 (95% CI: 1.60–3.39, p 2. It thus appears well suited for clinical use with minimal equipment, especially for GPs.

Published
2020

45. Lack of structural brain alteration associated with insomnia: Findings from the ENIGMA-Sleep working group

Author

Weihs, Antoine, Hanwen Bi, B��low, Robin, Eickhoff, Simon B., Ewert, Ralf, Frenzel, Stefan, Grabe, Hans J., Jahanshad, Neda, Habibolah Khazaie, Kaustubh Patil, Riemann, Dieter, Rostampour, Masoumeh, Schiel, Julian E., Spiegelhalder, Kai, Stubbe, Beate, Thomopoulos, Sophia I., Thompson, Paul M., Valk, Sofie L., V��lzke, Henry, Zarei, Mojtaba, and Tahmasian, Masoud

Published
2022
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46. The relationship between Alzheimer's‐related brain atrophy patterns and sleep macro‐architecture

Author

Weihs, Antoine, primary, Frenzel, Stefan, additional, Garvert, Linda, additional, Kühn, Luise, additional, Wittfeld, Katharina, additional, Ewert, Ralf, additional, Fietze, Ingo, additional, Penzel, Thomas, additional, Stubbe, Beate, additional, Szentkirályi, András, additional, Wulms, Niklas, additional, Völzke, Henry, additional, and Grabe, Hans J., additional

Published
2022
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50. Value of Cardiopulmonary Exercise Testing in the Prognosis Assessment of Chronic Obstructive Pulmonary Disease Patients: A Retrospective, Multicentre Cohort Study

Author

Ewert, Ralf, primary, Obst, Anne, additional, Mühle, Andreas, additional, Halank, Michael, additional, Winkler, Jörg, additional, Trümper, Bernd, additional, Hoheisel, Gerhard, additional, Hoheisel, Andreas, additional, Wiersbitzky, Mark, additional, Heine, Alexander, additional, Maiwald, Alexander, additional, Gläser, Sven, additional, and Stubbe, Beate, additional

Published
2021
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