Search

Your search keyword '"Strissel, Katherine"' showing total 169 results
Start Over Author "Strissel, Katherine"
169 results on '"Strissel, Katherine"'

9. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

Author

DeFuria, Jason, Belkina, Anna C., Jagannathan-Bogdan, Madhumita, Snyder-Cappione, Jennifer, Carr, Jordan David, Nersesova, Yanina R., Markham, Douglas, Strissel, Katherine J., Watkins, Amanda A., Zhu, Min, Allen, Jessica, Bouchard, Jacqueline, Toraldo, Gianluca, Jasuja, Ravi, Obin, Martin S., McDonnell, Marie E., Apovian, Caroline, Denis, Gerald V., and Nikolajczyk, Barbara S.

Published
2013

21. Relationships among obesity, Type 2 diabetes and plasma cytokines in African American women

Author

Denis, Gerald V., Sebastiani, Paola, Andrieu, Guillaume, Tran, Anna H., Strissel, Katherine J., Lombardi, Frank L., and Palmer, Julie R.

Subjects
Type 2 diabetes, Middle Aged, Article, cytokines, United States, Black or African American, Diabetes Mellitus, Type 2, inflammation, women’s health, African American women, Humans, Female, Obesity, Chemokines
Abstract

Objective The principal objective of this investigation was to identify novel cytokine associations with body mass index and Type 2 diabetes. Methods Cytokines were profiled from African American women with obesity who donated plasma to the Komen Tissue Bank. Multiplex bead arrays of analytes were used to quantify 88 cytokines and chemokines in association with clinical diagnoses of metabolic health. Regression models were generated after elimination of outliers. Results Among women with obesity, Type 2 diabetes was associated with breast adipocyte hypertrophy and with six plasma analytes, including four chemokines: chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 16 (CCL16), chemokine (C-X-C motif) ligand 1 (GRO-1) and chemokine (C-X-C motif) ligand 16 (CXCL16); and two growth factors: interleukin-2 and epidermal growth factor. In addition, three analytes were associated with obesity independently of diabetes: interleukin-4, soluble CD40 ligand and chemokine (C-C motif) ligand 3 (CCL3). Conclusions Profiling of inflammatory cytokines combined with measures of body mass index may produce a more personalized risk assessment for obesity-associated disease in African American women.

Published
2017

22. Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans

Author

Das, Sai Krupa, Roberts, Susan B., Bhapkar, Manjushri V., Villareal, Dennis T., Fontana, Luigi, Martin, Corby K., Racette, Susan B., Fuss, Paul J., Kraus, William E., Wong, William W., Saltzman, Edward, Pieper, Carl F., Fielding, Roger A., Schwartz, Ann V., Ravussin, Eric, Redman, Leanne M., Champagne, Catherine, Gupta, Alok, Smith, Steven, Williamson, Donald, Begnaud, Michelle, Cerniauskas, Barbara, Davis, Allison, Gabrielle, Jeanne, Walden, Heather, Currier, Natalie, Shipp, Mandy, Masters, Sarah, Mcnicoll, Melody, Prince, Shelly, Brock, Courtney, Puyau, Renee, Earnest, Conrad, Rood, Jennifer, Stewart, Tiffany, Levitan, Lillian, Traylor, Crystal, Thomas, Susan, Toups, Valerie, Jones, Karen, Tatum, Stephanie, Waguespack, Celeste, Crotwell, Kimberly, Dalfrey, Lisa, Braymer, Amy, Hilliard, Rhonda, Thomas, Onolee, Arceneaux, Jennifer, Laprarie, Stacie, Strate, Allison, Ihrig, Jana, Mancuso, Susan, Beard, Christy, Hymel, Alicia, Shepard, Desti, Correa, John, Jarreau, Denise, Dahmer, Brenda, Bella, Grace, Soroe, Elizabeth, Conner, Bridget, Mccown, Paige, Anaya, Stephanie, Lupo, Melissa, Meydani, Simin, Greenberg, Isaac, Pittas, Anastassios, Scott, Tammy, Gilhooly, Cheryl, Gerber, Kimberly, Kaplan, Marjory, Karabetian, Christy, Kennedy, Russell, Robinson, Lisa, Senait, Assefa, Bembridge, Verona, Berlis, Maria, Buer, Scarlett, Carabello, Robert, Campbell, Cherie, Collins, Lauren, Doherty, Marybeth, Freed, Alicia, Hernandez, Chervonte, Jean-baptiste, Gyna, Krasinski, Mary, Lim-lucas, Marie, Maslova, Ekaterina, Maxwell, Barbara, Mcshea, Jean, Muchowski, Ann, Mulkerrin, Margaret, Murphy, Kerry, Nelsen, Carol, O'Neill, Megan, Rasmussen, Helen, Roche, Brenda, Roman, Eneida, Sproull, Gregory, Victor, St Marie, Storer, Susan, Strissel, Katherine, Valliere, Stephanie, Vilme, Margaret, Wheeler, Justin, Wiley, Jill, Yangarber, Fania, Holloszy, John O., Klein, Sam, Lambert, Charles, Mohammed, B. Selma, Stein, Rick, Cotton, Karen, Hof, Margaret, Massmann, Cherie, Obert, Kathleen, Pearlman, Marni, Reising, Tina M., Weber, Laura, Uhrich, Mary, Schram, Morgan, Meyer, Mel, Carlen, Chelsea, Kee, Lisa, Larson, Barbara, Mcferson, Mary, Sabatino, Rebecca, Toennies, Bridgett, Rochon, James, Bales, Connie W., Galan, Katherine M., Adrian, Richard, Allen, Eleanor Law, Blasko, William, Brown, Nikka, Butts, Maria, Cossin, Elaina K., Curry, Jennifer, Daniel, Jamie, Diemer, Kathleen S., Greiner, Lee, Johnson, Darryl, Jones, Cassandra, Lindblad, Lauren, Mcadams, Luanne, Mansfield, Marty, Murugesan, Senthil, Piner, Lucy, Plummer, Christopher, Revoir, Mike, Smith, Pamela, Spaulding, Monica, Topping, James, Clarke, Lucinda L., Liu, Chun W., Fraley, J. Kennard, Shepherd, John, Palermo, Lisa, Ewing, Susan, Rahorst, Michaela, Navy, Caroline, Lewis, Michael, Tracy, Russell P., Boyle, Rebekah, Cornell, Elaine, Daunais, Patrick, Draayer, Dean, Floersch, Melissa, Gagne, Nicole, Keating, Florence, Patnoad, Angela, Schmidt, Marcia, Gavin, Marcia, Wiener, Frida, Hughes, Ashley, Benken, Laura, Otto, Amy, Halter, Jeffrey, Buchner, David M., Elmer, Patricia, Espeland, Mark, Heymsfield, Steven B., Pi-sunyer, Xavier, Prohaska, Thomas, Shapses, Sue, Speakman, John, Weindruch, Richard, Hadley, Evan C., Hannah, Judy, Romashkan, Sergei, and Evans, Mary

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Waist, CALERIE, Longevity, Calorie restriction, Medicine (miscellaneous), Body composition, Humans, Longterm, Nonobese, Adipose Tissue, Adiposity, Body Fluid Compartments, Body Weight, Diet, Energy Metabolism, Female, Sex Factors, Time, Torso, Waist Circumference, Body Composition, Body Mass Index, Caloric Restriction, Energy Intake, Weight Loss, Nutrition and Dietetics, 030209 endocrinology & metabolism, Doubly labeled water, Biology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Weight loss, Internal medicine, medicine, Fluid compartments, 030104 developmental biology, Endocrinology, medicine.symptom, Body mass index
Abstract

Background: Calorie restriction (CR) retards aging and increases longevity in many animal models. However, it is unclear whether CR can be implemented in humans without adverse effects on body composition.Objective: We evaluated the effect of a 2-y CR regimen on body composition including the influence of sex and body mass index (BMI; in kg/m2) among participants enrolled in CALERIE-2 (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy), a multicenter, randomized controlled trial.Design: Participants were 218 nonobese (BMI: 21.9-28.0) adults aged 21-51 y who were randomly assigned to 25% CR (CR, n = 143) or ad libitum control (AL, n = 75) in a 2:1 ratio. Measures at baseline and 12 and 24 mo included body weight, waist circumference, fat mass (FM), fat-free mass (FFM), and appendicular mass by dual-energy X-ray absorptiometry; activity-related energy expenditure (AREE) by doubly labeled water; and dietary protein intake by self-report. Values are expressed as means ± SDs.Results: The CR group achieved 11.9% ± 0.7% CR over 2-y and had significant decreases in weight (-7.6 ± 0.3 compared with 0.4 ± 0.5 kg), waist circumference (-6.2 ± 0.4 compared with 0.9 ± 0.5 cm), FM (-5.4 ± 0.3 compared with 0.5 ± 0.4 kg), and FFM (-2.0 ± 0.2 compared with -0.0 ± 0.2 kg) at 24 mo relative to the AL group (all between-group P < 0.001). Moreover, FFM as a percentage of body weight at 24 mo was higher, and percentage of FM was lower in the CR group than in the AL. AREE, but not protein intake, predicted preservation of FFM during CR (P < 0.01). Men in the CR group lost significantly more trunk fat (P = 0.03) and FFM expressed as a percentage of weight loss (P < 0.001) than women in the CR group.Conclusions: Two years of CR had broadly favorable effects on both whole-body and regional adiposity that could facilitate health span in humans. The decrements in FFM were commensurate with the reduced body mass; although men in the CR group lost more FFM than the women did, the percentage of FFM in the men in the CR group was higher than at baseline. CALERIE was registered at clinicaltrials.gov as NCT00427193.

Published
2017
Full Text
View/download PDF

28. Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1-alpha autocrine loop

Author

West-Mays, Judith A., Strissel, Katherine J., Sadow, Peter M., and Fini, M. Elizabeth

Subjects
Interleukin-1 -- Physiological aspects, Collagenases -- Research, Science and technology
Abstract

Interleukin 1-alpha (IL-1-alpha), an autocrine cytokine, controls the stimulation of collagenase expression in response to trypsin, cytochalasin B or phorbol 12-myristate 13-acetate in early-passage fibroblasts. An autocrine feedback loop maintains the amount of IL-1-alpha formed due to activation by these stimulators. However, freshly isolated fibroblasts cannot maintain this feedback loop because they do not form the IL-1-alpha gene. The activation of IL-1-alpha when the actin stress fibers are disrupted probably involves a mitogen-activated protein kinase.

Published
1995

41. Perilipin overexpression in mice protects against diet-induced obesity

Author

1000030360902, Miyoshi, Hideaki, Souza, Sandra C., Endo, Mikiko, Sawada, Takashi, Perfield, James W. II, 1000000292029, Shimizu, Chikara, Stancheva, Zlatina, 1000070507590, Nagai, So, Strissel, Katherine J., 1000020200941, Yoshioka, Narihito, Obin, Martin S., 1000080146795, Koike, Takao, Greenberg, Andrew S., 1000030360902, Miyoshi, Hideaki, Souza, Sandra C., Endo, Mikiko, Sawada, Takashi, Perfield, James W. II, 1000000292029, Shimizu, Chikara, Stancheva, Zlatina, 1000070507590, Nagai, So, Strissel, Katherine J., 1000020200941, Yoshioka, Narihito, Obin, Martin S., 1000080146795, Koike, Takao, and Greenberg, Andrew S.

Abstract

Perilipin A is the most abundant phosphoprotein on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Perilipin null mice exhibit diminished adipose tissue, elevated basal lipolysis, reduced catecholamine-stimulated lipolysis, and increased insulin resistance. To understand the physiological consequences of increased perilipin expression in vivo, we generated transgenic mice that overexpressed either human or mouse perilipin using the adipocyte-specific aP2 promoter/enhancer. Phenotypes of female transgenic and wild-type mice were characterized on chow and high-fat diets (HFDs). When challenged with an HFD, transgenic mice exhibited lower body weight, fat mass, and adipocyte size than wild-type mice. Expression of oxidative genes was increased and lipogenic genes decreased in brown adipose tissue of transgenic mice. Basal and catecholamine-stimulated lipolysis was decreased and glucose tolerance significantly improved in transgenic mice fed a HFD. Perilipin overexpression in adipose tissue protects against HFD-induced adipocyte hypertrophy, obesity, and glucose intolerance. Alterations in brown adipose tissue metabolism may mediate the effects of perilipin overexpression on body fat, although the mechanisms by which perilipin overexpression alters brown adipose tissue metabolism remain to be determined. Our findings demonstrate a novel role for perilipin expression in adipose tissue metabolism and regulation of obesity and its metabolic complications.

Published
2010

42. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and independent mechanisms

Author

1000030360902, Miyoshi, Hideaki, Souza, Sandra C., Zhang, Hui-Hong, Strissel, Katherine, Christoffolete, Marcelo A, Kovsan, Julia, Rudich, Assaf, Kraemer, Fredric B., Bianco, Antonio C., Martin S., Obin, Greenberg, Andrew S., 1000030360902, Miyoshi, Hideaki, Souza, Sandra C., Zhang, Hui-Hong, Strissel, Katherine, Christoffolete, Marcelo A, Kovsan, Julia, Rudich, Assaf, Kraemer, Fredric B., Bianco, Antonio C., Martin S., Obin, and Greenberg, Andrew S.

Abstract

Hormone-sensitive lipase (HSL) is the predominant lipase effector of catecholamine-stimulated lipolysis in adipocytes. HSL-dependent lipolysis in response to catecholamines is mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin A (Peri A), an essential lipid droplet (LD)-associated protein. It is believed that perilipin phosphorylation is essential for the translocation of HSL from the cytosol to the LD, a key event in stimulated lipolysis. Using adipocytes retrovirally engineered from murine embryonic fibroblasts of perilipin null mice (Peri–/– MEF), we demonstrate by cell fractionation and confocal microscopy that up to 50% of cellular HSL is LD-associated in the basal state and that PKA-stimulated HSL translocation is fully supported by adenoviral expression of a mutant perilipin lacking all six PKA sites (Peri A1–6). PKA-stimulated HSL translocation was confirmed in differentiated brown adipocytes from perilipin null mice expressing an adipose-specific Peri A1–6 transgene. Thus, PKA-induced HSL translocation was independent of perilipin phosphorylation. However, Peri A1–6 failed to enhance PKA-stimulated lipolysis in either MEF adipocytes or differentiated brown adipocytes. Thus, the lipolytic action(s) of HSL at the LD surface requires PKA-dependent perilipin phosphorylation. In Peri–/– MEF adipocytes, PKA activation significantly enhanced the amount of HSL that could be cross-linked to and co-immunoprecipitated with ectopic Peri A. Notably, this enhanced cross-linking was blunted in Peri–/– MEF adipocytes expressing Peri A1–6. This suggests that PKA-dependent perilipin phosphorylation facilitates (either direct or indirect) perilipin interaction with LD-associated HSL. These results redefine and expand our understanding of how perilipin regulates HSL-mediated lipolysis in adipocytes.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results