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27 results on '"Stout, E. Paige"'

6. Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus

Author

Lane, Amy L., Stout, E. Paige, An-Shen Lin, Prudhomme, Jacques, Le Roch, Karine, Fairchild, Craig R., Franzblau, Scott G., Hay, Mark E., Aalbersberg, William, and Kubanek, Julia

Subjects
Macrolide antibiotics -- Chemical properties, Macrolide antibiotics -- Structure, Mass spectrometry -- Usage, Nuclear magnetic resonance spectroscopy -- Usage, Plasmodium falciparum -- Research, Biological sciences, Chemistry
Abstract

Bromophycolides J-Q is isolated from extracts of the Fijian red alga Callophycus serratus and is identified with one-dimensional (1D) and 2D NMR spectroscopy and mass spectral analyses. The diterpene-benzoate macrolides have represented two novel carbon skeletons and bromophycolides have displayed activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.

Published
2009

7. Cytotoxic effects on tumour cell lines of fatty acids from the marine sponge S copalina ruetzleri

Author

Biegelmeyer, Renata, primary, Schröder, Rafael, additional, Rambo, Douglas F, additional, Dresch, Roger R, additional, Stout, E Paige, additional, Carraro, João L F, additional, Mothes, Beatriz, additional, Moreira, José C F, additional, Molinski, Tadeusz F, additional, da Frota Junior, Mário L C, additional, and Henriques, Amélia T, additional

Published
2015
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14. Agelastatin A (AgA), a Marine Sponge Derived Alkaloid, Inhibits Wnt/Beta-Catenin Signaling and Selectively Induces Apoptosis in Chronic Lymphocytic Leukemia Independently of p53

Author

Choi, Michael Y., primary, Cardenas, Johanna Melo, additional, Lu, Desheng, additional, Yu, Jian, additional, Stout, E. Paige, additional, Wu, Raymond P., additional, Horton, John M, additional, Gomez, Allison, additional, Diaz-Perez, Julio A., additional, Carson, Dennis A., additional, Molinski, Tadeusz F., additional, Kipps, Thomas J., additional, and Castro, Januario E., additional

Published
2011
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22. Halisphingosines A and B, Modified Sphingoid Bases from Haliclona tubifera. Assignment of Configuration by Circular Dichroism and van’t Hoff’s Principle of Optical Superposition

Author

Molinski, Tadeusz F., Biegelmeyer, Renata, Stout, E. Paige, Wang, Xiao, Frota, Mario L. C., and Henriques, Amelia T.

Abstract

Halisphingosines A (1) and B (2), modified long-chain sphingoid bases, from the marine sponge Haliclona tubiferacollected in Brazil, were characterized after conversion to their N-Boc derivatives. The 2R,3R,6Rconfiguration of halisphingosine A, a compound first reported from Haliclonasp. from South Korea, was confirmed using a novel CD approach: deconvolution of exciton coupling from mono- and trinaphthoyl derivatives obtained by derivatization of the natural product. The sensitive CD deconvolution method, applicable to submilligram samples, simultaneously predicted the relative and absolute configuration of three stereocenters in halisphingosine A with precision and accuracy. Halisphingosine B was assigned by correlation to halisphingosine A.

Published
2013
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23. Pyrrole Aminoimidazole Alkaloid Metabiosynthesis with Marine Sponges Agelas coniferaand Stylissa caribica

Author

Stout, E. Paige, Wang, Yong‐Gang, Romo, Daniel, and Molinski, Tadeusz F.

Abstract

Game‐SET‐match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell‐free enzyme preparations from PAI‐producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single‐electron transfers (SETs) that promote CC bond‐forming reactions of precursors.

Published
2012
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25. Cytotoxic effects on tumour cell lines of fatty acids from the marine sponge Scopalina ruetzleri.

Author

Biegelmeyer R, Schröder R, Rambo DF, Dresch RR, Stout EP, Carraro JL, Mothes B, Moreira JC, Molinski TF, da Frota Junior ML, and Henriques AT

Subjects
Animals, Antineoplastic Agents chemistry, Antioxidants chemistry, Antioxidants pharmacology, Cell Line, Tumor, Fatty Acids chemistry, Fatty Acids toxicity, Humans, Antineoplastic Agents pharmacology, Cell Survival drug effects, Fatty Acids pharmacology, Porifera chemistry
Abstract

Objectives: Marine sponges are among the most promising sources of chemically diversified fatty acids (FAs). In addition, several studies have shown the effect of polyunsaturated FAs on cancer therapy. This research carried out a biological and chemical evaluation of the sponge Scopalina ruetzleri collected on the South Brazilian coastline., Methods: Bioassay-guided fractionation of S. ruetzleri was performed in human glioma (U87) and neuroblastoma (SH-SY5Y) cell lines, and the in-vitro effects on free radicals were evaluated., Key Findings: The ethyl acetate fraction of S. ruetzleri showed promising cytotoxic effects in cancer cell lines, with IC50  < 20 μg/ml. Fingerprint (1) H Nuclear Magnetic Resonance (NMR) analysis showed that this fraction is mainly constituted of FAs. Through FA methyl ester analysis, it was possible to identify 32 FAs. In addition, some minor unusual FAs for the marine biosphere were identified. The results of conjugated dienes method showed that FAs fraction, at concentrations above 50 μg/ml, has a pro-oxidant effect, indicating that lipid peroxidation may be partially responsible for the mechanism of cytotoxicity on cancer cells., Conclusion: This work also contributes to studies that focus on the application of FAs on cancer therapy as a new adjuvant to radio or chemotherapy, or as a chemotherapeutic agent., (© 2015 Royal Pharmaceutical Society.)

Published
2015
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26. Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica.

Author

Stout EP, Wang YG, Romo D, and Molinski TF

Subjects
Agelas chemistry, Alkaloids chemical synthesis, Animals, Imidazoles chemical synthesis, Porifera chemistry, Pyrroles chemical synthesis, Agelas metabolism, Alkaloids biosynthesis, Imidazoles metabolism, Porifera metabolism, Pyrroles metabolism
Abstract

Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors., (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2012
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27. Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.

Author

Lin AS, Stout EP, Prudhomme J, Le Roch K, Fairchild CR, Franzblau SG, Aalbersberg W, Hay ME, and Kubanek J

Subjects
Amphotericin B pharmacology, Antimalarials chemistry, Candida albicans drug effects, Diterpenes chemistry, Drug Resistance drug effects, Drug Screening Assays, Antitumor, Enterococcus faecium drug effects, Female, Fiji, Humans, Macrolides chemistry, Male, Methicillin-Resistant Staphylococcus aureus drug effects, Molecular Structure, Mycobacterium tuberculosis drug effects, Nuclear Magnetic Resonance, Biomolecular, Plasmodium falciparum drug effects, Vancomycin pharmacology, Antimalarials isolation & purification, Antimalarials pharmacology, Diterpenes isolation & purification, Diterpenes pharmacology, Macrolides isolation & purification, Macrolides pharmacology, Rhodophyta chemistry
Abstract

Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.

Published
2010
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