Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica.

Authors :: Stout EP
Wang YG
Romo D
Molinski TF
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2012 May 14; Vol. 51 (20), pp. 4877-81. Date of Electronic Publication: 2012 Apr 04.
Publication Year :: 2012
Abstract: Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Agelas chemistry
Alkaloids chemical synthesis
Animals
Imidazoles chemical synthesis
Porifera chemistry
Pyrroles chemical synthesis
Agelas metabolism
Alkaloids biosynthesis
Imidazoles metabolism
Porifera metabolism
Pyrroles metabolism

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