522 results on '"Stine, O Colin"'
Search Results
2. NewVibrio choleraesequences from Eastern and Southern Africa alter our understanding of regional cholera transmission
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Xiao, Shaoming, primary, Abade, Ahmed, additional, Boru, Waqo, additional, Kasambara, Watipaso, additional, Mwaba, John, additional, Ongole, Francis, additional, Mmanywa, Mariam, additional, Trovão, Nídia Sequeira, additional, Chilengi, Roma, additional, Kwenda, Geoffrey, additional, Orach, Christopher Garimoi, additional, Chibwe, Innocent, additional, Bwire, Godfrey, additional, Stine, O. Colin, additional, Milstone, Aaron M., additional, Lessler, Justin, additional, Azman, Andrew S., additional, Luo, Wensheng, additional, Murt, Kelsey, additional, Sack, David A., additional, Debes, Amanda K., additional, and Wohl, Shirlee, additional
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- 2024
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3. Factors associated with patient-to-healthcare personnel (HCP) and HCP-to-subsequent patient transmission of methicillin-resistant Staphylococcus aureus
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Adediran, Timileyin Y., primary, Robinson, Gwen L., additional, Johnson, J. Kristie, additional, Liang, Yuanyuan, additional, Bejo, Sarah, additional, Leekha, Surbhi, additional, Rasko, David A., additional, Stine, O. Colin, additional, Harris, Anthony D., additional, and Thom, Kerri A., additional
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- 2024
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4. Three transmission events of Vibrio cholerae O1 into Lusaka, Zambia
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Mwaba, John, Debes, Amanda K., Murt, Kelsey N., Shea, Patrick, Simuyandi, Michelo, Laban, Natasha, Kazimbaya, Katayi, Chisenga, Caroline, Li, Shan, Almeida, Mathieu, Meisel, Jacquelyn S., Shibemba, Aaron, Kantenga, Timothy, Mukonka, Victor, Kwenda, Geoffrey, Sack, David A., Chilengi, Roma, and Stine, O. Colin
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- 2021
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5. Meta-analysis of the lung microbiota in pulmonary tuberculosis
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Hong, Bo-young, Paulson, Joseph N., Stine, O. Colin, Weinstock, George M., and Cervantes, Jorge L.
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- 2018
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6. Analysis of Aichi virus and Saffold virus association with pediatric acute gastroenteritis
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Li, Li-li, Liu, Na, Yu, Jei-mei, Ao, Yuan-yun, Li, Shan, Stine, O. Colin, and Duan, Zhao-jun
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- 2017
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7. A framework for assessing 16S rRNA marker-gene survey data analysis methods using mixtures.
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Olson, Nathan D., Kumar, M. Senthil, Li, Shan, Braccia, Domenick J., Hao, Stephanie, Timp, Winston, Salit, Marc L., Stine, O. Colin, and Bravo, Hector Corrada
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- 2020
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8. Comparison of molecular typing methods for the analyses of Acinetobacter baumannii from ICU patients
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Johnson, J. Kristie, Robinson, Gwen L., Zhao, LiCheng, Harris, Anthony D., Stine, O. Colin, and Thom, Kerri A.
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- 2016
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9. Circulation and Transmission of Clones of Vibrio cholerae During Cholera Outbreaks
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Stine, O. Colin, Morris, J. Glenn, Jr., Compans, Richard W, Series editor, Cooper, Max D., Series editor, Gleba, Yuri Y., Series editor, Honjo, Tasuku, Series editor, Oldstone, Michael B. A., Series editor, Vogt, Peter K., Series editor, Malissen, Bernard, Series editor, Aktories, Klaus, Series editor, Kawaoka, Yoshihiro, Series editor, Rappuoli, Rino, Series editor, Galan, Jorge E., Series editor, Nair, G. Balakrish, editor, and Takeda, Yoshifumi, editor
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- 2014
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10. Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study
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Larsson, Susanna C., Traylor, Matthew, Burgess, Stephen, Boncoraglio, Giorgio B., Jern, Christina, Michaëlsson, Karl, Markus, Hugh S., Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, raci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Jr., Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul IW, DeStefano, Anita L, Hoed, Marcel den, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I, Ikram, M Arfan, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei-Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, OʼDonnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil-Smoller, Sylvia, Wilson, James G, Wiggins, Kerri L, Yang, Qiong, Yusuf, Salim, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu-Ching, Choi, Seung Hoan, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean-François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Liu, Yong Mei, Lopez, Oscar L, Makoto, Hirata, Martinez-Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Peddareddygari, Leema Reddy, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano-Tárraga, Carolina, Stanne, Tara, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres-Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Longstreth, W T, Jr, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin
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- 2019
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11. Akkermansia muciniphila Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo
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George, Christine Marie, primary, Birindwa, Alves, additional, Li, Shan, additional, Williams, Camille, additional, Kuhl, Jennifer, additional, Thomas, Elizabeth, additional, François, Ruthly, additional, Presence, Amani Sanvura, additional, Claude, Bisimwa Rusanga Jean, additional, Mirindi, Patrick, additional, Bisimwa, Lucien, additional, Perin, Jamie, additional, and Stine, O. Colin, additional
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- 2022
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12. Molecular concordance of methicillin-resistant Staphylococcus aureus isolates from healthcare workers and patients
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Adediran, Timileyin Y., primary, Hitchcock, Stephanie, additional, Johnson, J. Kristie, additional, Stine, O. Colin, additional, Leekha, Surbhi, additional, Thom, Kerri A., additional, Liang, Yuanyuan, additional, Rasko, David A., additional, and Harris, Anthony D., additional
- Published
- 2022
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13. Enteric Infections in Young Children are Associated with Environmental Enteropathy and Impaired Growth
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George, Christine Marie, Burrowes, Vanessa, Perin, Jamie, Oldja, Lauren, Biswas, Shwapon, Sack, David, Ahmed, Shahnawaz, Haque, Rashidul, Bhuiyan, Nurul Amin, Parvin, Tahmina, Bhuyian, Sazzadul Islam, Akter, Mahmuda, Li, Shan, Natarajan, Gayathri, Shahnaij, Mohammad, Faruque, Abu G., and Stine, O. Colin
- Published
- 2018
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14. Shigella infections in household contacts of pediatric shigellosis patients in rural Bangladesh
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George, Christine Marie, Ahmed, Shahnawaz, Talukder, Kaisar A., Azmi, Ishrat J., Perin, Jamie, Sack, R. Bradley, Sack, David A., Stine, O. Colin, Oldja, Lauren, Shahnaij, Mohammad, Chakraborty, Subhra, Parvin, Tahmina, Bhuyian, Sazzadul Islam, Bouwer, Edward, Zhang, Xiaotong, Hasan, Trisheeta N., Luna, Sharmin J., Akter, Fatema, and Faruque, Abu S.G.
- Subjects
Bacillary dysentery -- Health aspects ,Pediatrics -- Health aspects ,Infection -- Health aspects ,Households -- Health aspects ,Health - Abstract
In South Asia and Africa, an estimated 88.5 million diarrhea episodes are attributed to Shigella infections annually (1). Shigellosis occurs most often in children < 5 years of age (2,3). [...]
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- 2015
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15. Stroke genetics informs drug discovery and risk prediction across ancestries
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Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C, Kamanu, Frederick K, Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C, Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Borge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Wilson, Peter WF, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michele M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-Francois, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke JH, Kappelle, L Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie LM, Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent NS, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Muller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Volker, Uwe, de Laat, Karlijn F, van Norden, Anouk GW, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul JAM, Gons, Rob AR, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank GW, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A, Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet MJ, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna MM, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Korv, Janika, Franca, Paulo HC, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Longstreth, WT, Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Zwart, John-Anker, Niiranen, Teemu J, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, Debette, Stephanie, Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jurgenson, Tuuli, Namba, Shinichi, Posner, Daniel C, Kamanu, Frederick K, Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K, Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C, Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R, Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V, Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Carcel-Marquez, Jara, Nygaard, Marianne, Leonard, Hampton L, Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J, Lewis, Adam J, Judy, Renae L, Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D, Bakker, Mark K, Bartz, Traci M, Bennett, David A, Bis, Joshua C, Bordes, Constance, Borte, Sigrid, Cain, Anael, Ridker, Paul M, Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W, de Jager, Phil L, de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E, Geerlings, Mirjam I, Gasca, Natalie C, Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K, Ho, Yuk-Lam, Havulinna, Aki S, Hopewell, Jemma C, Hyacinth, Hyacinth I, Inouye, Michael, Jacob, Mina A, Jeon, Christina E, Jern, Christina, Kamouchi, Masahiro, Keene, Keith L, Kitazono, Takanari, Kittner, Steven J, Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J, Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S, Marston, Nicholas A, Meitinger, Thomas, Mitchell, Braxton D, Montellano, Felipe A, Morisaki, Takayuki, Mosley, Thomas H, Nalls, Mike A, Nordestgaard, Borge G, O'Donnell, Martin J, Okada, Yukinori, Onland-Moret, N Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M, Rich, Stephen S, Rosand, Jonathan, Sabatine, Marc S, Sacco, Ralph L, Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L, Schmidt, Carsten O, Shimizu, Atsushi, Smith, Nicholas L, Sloane, Kelly L, Sutoh, Yoichi, Sun, Yan V, Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P, Tiwari, Hemant K, Tregouet, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjaerg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S, Wiggins, Kerri L, Wennberg, Patrik, Woo, Daniel, Wilson, Peter WF, Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Lee, Jin-Moo, Cheng, Yu-Ching, Meschia, James F, Chen, Wei Min, Sale, Michele M, Zonderman, Alan B, Evans, Michele K, Wilson, James G, Correa, Adolfo, Traylor, Matthew, Lewis, Cathryn M, Carty, Cara L, Reiner, Alexander, Haessler, Jeffrey, Langefeld, Carl D, Gottesman, Rebecca F, Yaffe, Kristine, Liu, Yong Mei, Kooperberg, Charles, Lange, Leslie A, Furie, Karen L, Arnett, Donna K, Benavente, Oscar R, Grewal, Raji P, Peddareddygari, Leema Reddy, Hveem, Kristian, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Brumpton, Ben M, Suchon, Pierre, Chen, Ming-Huei, Frazer, Kelly A, Turman, Constance, Germain, Marine, MacDonald, James, Braekkan, Sigrid K, Armasu, Sebastian M, Pankratz, Nathan, Jackson, Rebecca D, Nielsen, Jonas B, Giulianini, Franco, Puurunen, Marja K, Ibrahim, Manal, Heckbert, Susan R, Bammler, Theo K, McCauley, Bryan M, Taylor, Kent D, Pankow, James S, Reiner, Alexander P, Gabrielsen, Maiken E, Deleuze, Jean-Francois, O'Donnell, Chris J, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R, Heit, John A, Tang, Weihong, Morange, Pierre-Emmanuel, Johnson, Andrew D, Kabrhel, Christopher, van Dijk, Ewoud J, Koudstaal, Peter J, Luijckx, Gert-Jan, Nederkoorn, Paul J, van Oostenbrugge, Robert J, Visser, Marieke C, Wermer, Marieke JH, Kappelle, L Jaap, Esko, Tonu, Metspalu, Andres, Magi, Reedik, Nelis, Mari, Irvin, Marguerite R, de Leeuw, Frank-Erik, Levi, Christopher R, Maguire, Jane, Jimenez-Conde, Jordi, Sharma, Pankaj, Sudlow, Cathie LM, Rannikmae, Kristiina, Schmidt, Reinhold, Slowik, Agnieszka, Pera, Joanna, Thijs, Vincent NS, Lindgren, Arne G, Ilinca, Andreea, Melander, Olle, Engstrom, Gunnar, Rexrode, Kathryn M, Rothwell, Peter M, Stanne, Tara M, Johnson, Julie A, Danesh, John, Butterworth, Adam S, Heitsch, Laura, Boncoraglio, Giorgio B, Kubo, Michiaki, Pezzini, Alessandro, Rolfs, Arndt, Giese, Anne-Katrin, Weir, David, Ross, Owen A, Lemmons, Robin, Soderholm, Martin, Cushman, Mary, Jood, Katarina, McDonough, Caitrin W, Bell, Steven, Linkohr, Birgit, Lee, Tsong-Hai, Putaala, Jukka, Anderson, Christopher D, Lopez, Oscar L, Jian, Xueqiu, Schminke, Ulf, Cullell, Natalia, Delgado, Pilar, Ibanez, Laura, Krupinski, Jerzy, Lioutas, Vasileios, Matsuda, Koichi, Montaner, Joan, Muino, Elena, Roquer, Jaume, Sarnowski, Chloe, Sattar, Naveed, Sibolt, Gerli, Teumer, Alexander, Rutten-Jacobs, Loes, Kanai, Masahiro, Gretarsdottir, Solveig, Rost, Natalia S, Yusuf, Salim, Almgren, Peter, Ay, Hakan, Bevan, Steve, Brown, Robert D, Carrera, Caty, Buring, Julie E, Chen, Wei-Min, Cotlarciuc, Ioana, de Bakker, Paul IW, DeStefano, Anita L, den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gustafsson, Stefan, Hassan, Ahamad, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Ingelsson, Erik, Harris, Tamara B, Kissela, Brett M, Kleindorfer, Dawn O, Langenberg, Claudia, Lemmens, Robin, Leys, Didier, Lin, Wei-Yu, Lorentzen, Erik, Magnusson, Patrik K, McArdle, Patrick F, Pulit, Sara L, Rice, Kenneth, Sakaue, Saori, Sapkota, Bishwa R, Tanislav, Christian, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Amin, Najaf, Aparicio, Hugo J, Attia, John, Beiser, Alexa S, Berr, Claudine, Bustamante, Mariana, Caso, Valeria, Choi, Seung Hoan, Chowhan, Ayesha, Dartigues, Jean-Francois, Delavaran, Hossein, Dorr, Marcus, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Hozawa, Atsushi, Ingelsson, Martin, Iwasaki, Motoki, Kaffashian, Sara, Kalra, Lalit, Kjartansson, Olafur, Kloss, Manja, Labovitz, Daniel L, Laurie, Cathy C, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Makoto, Hirata, Minegishi, Naoko, Morris, Andrew P, Muller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Pedersen, Nancy L, Perola, Markus, Jousilahti, Pekka, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribases, Marta, Romero, Jose R, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Satoh, Mamoru, Sawada, Norie, Sigurdsson, Asgeir, Smith, Albert, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Wakai, Kenji, Williams, Stephen R, Wolfe, Charles DA, Wong, Quenna, Yamaji, Taiki, Sanghera, Dharambir K, Stefansson, Kari, Martinez-Majander, Nicolas, Sobue, Kenji, Soriano-Tarraga, Carolina, Volzke, Henry, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Obiako, Reginald, Wahab, Kolawole, Osaigbovo, Godwin, Owolabi, Lukman, Komolafe, Morenikeji, Jenkins, Carolyn, Arulogun, Oyedunni, Ogbole, Godwin, Adeoye, Abiodun M, Akinyemi, Joshua, Agunloye, Atinuke, Fakunle, Adekunle G, Uvere, Ezinne, Olalere, Abimbola, Adebajo, Olayinka J, Chen, Junshi, Clarke, Robert, Collins, Rory, Guo, Yu, Wang, Chen, Lv, Jun, Peto, Richard, Chen, Yiping, Fairhurst-Hunter, Zammy, Hill, Michael, Pozarickij, Alfred, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Yu, Canqing, Nagai, Akiko, Murakami, Yoishinori, Shiroma, Eric J, Sigurdsson, Sigurdur, Ghanbari, Mohsen, Boerwinkle, Eric, Fongang, Bernard, Wang, Ruiqi, Ikram, Mohammad K, Volker, Uwe, de Laat, Karlijn F, van Norden, Anouk GW, de Kort, Paul L, Vermeer, Sarah E, Brouwers, Paul JAM, Gons, Rob AR, den Heijer, Tom, van Dijk, Gert W, van Rooij, Frank GW, Aamodt, Anne H, Skogholt, Anne H, Willer, Cristen J, Heuch, Ingrid, Hagen, Knut, Fritsche, Lars G, Pedersen, Linda M, Ellekjaer, Hanne, Zhou, Wei, Martinsen, Amy E, Kristoffersen, Espen S, Thomas, Laurent F, Kleinschnitz, Christoph, Frantz, Stefan, Ungethum, Kathrin, Gallego-Fabrega, Cristina, Lledos, Miquel, Llucia-Carol, Laia, Sobrino, Tomas, Campos, Francisco, Castillo, Jose, Freijo, Marimar, Arenillas, Juan Francisco, Obach, Victor, Alvarez-Sabin, Jose, Molina, Carlos A, Ribo, Marc, Munoz-Narbona, Lucia, Lopez-Cancio, Elena, Millan, Monica, Diaz-Navarro, Rosa, Vives-Bauza, Cristofol, Serrano-Heras, Gemma, Segura, Tomas, Dhar, Rajat, Delgado-Mederos, Raquel, Prats-Sanchez, Luis, Camps-Renom, Pol, Blay, Natalia, Sumoy, Lauro, Marti-Fabregas, Joan, Schnohr, Peter, Jensen, Gorm B, Benn, Marianne, Afzal, Shoaib, Kamstrup, Pia R, van Setten, Jessica, van der Laan, Sander W, Vonk, Jet MJ, Kim, Bong-Jo, Curtze, Sami, Tiainen, Marjaana, Kinnunen, Janne, Menon, Vilas, Sung, Yun Ju, Yang, Chengran, Saillour-Glenisson, Florence, Gravel, Simon, Millwood, Iona Y, Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J, Jukema, J Wouter, Rissanen, Ina L, Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna MM, Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A, Rundek, Tatjana, Worrall, Bradford B, Lathrop, G Mark, Riaz, Moeen, Simonsick, Eleanor M, Korv, Janika, Franca, Paulo HC, Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M, Heuschmann, Peter Ulrich, Longstreth, WT, Jung, Keum Ji, Bastarache, Lisa, Pare, Guillaume, Damrauer, Scott M, Chasman, Daniel I, Rotter, Jerome I, Zwart, John-Anker, Niiranen, Teemu J, Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernandez-Cadenas, Israel, Walters, Robin G, Ruff, Christian T, Owolabi, Mayowa O, Huffman, Jennifer E, Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie
- Abstract
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
- Published
- 2022
16. Mouse Models and Genetic Modifiers in X-Linked Adrenoleukodystrophy
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Heinzer, Ann K., Mcguinness, Martina C., Lu, Jyh-Feng, Stine, O. Colin, Wei, Heming, Van Der Vlies, Mark, Dong, Gao-Xiang, Powers, James, Watkins, Paul A., Smith, Kirby D., Roels, Frank, editor, Baes, Myriam, editor, and De Bie, Sylvia, editor
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- 2003
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17. Characterization of Microbial Communities from Coastal Waters Using Microarrays
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Stine, O. Colin, Carnahan, Amy, Singh, Ruby, Powell, Jan, Furuno, Jon P., Dorsey, Alicia, Silbergeld, Ellen, Williams, Henry N., Morris, J. Glenn, Melzian, Brian D., editor, Engle, Virginia, editor, McAlister, Malissa, editor, Sandhu, Shabeg, editor, and Eads, Lisa Kay, editor
- Published
- 2003
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18. Niche Partition of Bacteriovorax Operational Taxonomic Units Along Salinity and Temporal Gradients in the Chesapeake Bay Reveals Distinct Estuarine Strains
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Pineiro, Silvia, Chauhan, Ashvini, Berhane, Timkhite-kulu, Athar, Rana, Zheng, Guili, Wang, Cynthia, Dickerson, Tamar, Liang, Xiaobing, Lymperopoulou, Despoina S., Chen, Huan, Christman, Mary, Louime, Clifford, Babiker, Wisal, Stine, O. Colin, and Williams, Henry N.
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- 2013
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19. Microbiota that affect risk for shigellosis in children in low-income countries
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Lindsay, Brianna, Oundo, Joe, Hossain, M. Anowar, Antonio, Martin, Tamboura, Boubou, Walker, Alan W., Paulson, Joseph N., Parkhill, Julian, Omore, Richard, Faruque, Abu S.G., Das, Suman Kumar, Ikumapayi, Usman N., Adeyemi, Mitchell, Sanogo, Doh, Saha, Debasish, Sow, Samba, Farag, Tamer H., Nasrin, Dilruba, Li, Shan, Panchalingam, Sandra, Levine, Myron M., Kotloff, Karen, Magder, Laurence S., Hungerford, Laura, Sommerfelt, Halvor, Pop, Mihai, Nataro, James P., and Stine, O. Colin
- Subjects
Microbiota (Symbiotic organisms) -- Health aspects ,Diarrhea -- Health aspects ,Gastrointestinal system -- Health aspects ,RNA -- Health aspects ,Escherichia coli -- Health aspects ,Health - Abstract
Diarrheal disease contributes substantially to illness and death in children in low-income countries (1,2). Recent investigations of enteric illness have shown many cases with >1 pathogen identified (3-5). The paradigm [...]
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- 2015
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20. Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium.
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Xu, Huichun, Nguyen, Kevin, Gaynor, Brady J., Ling, Hua, Zhao, Wei, McArdle, Patrick F., O'Connor, Timothy D., Stine, O. Colin, Ryan, Kathleen A., Lynch, Megan, Smith, Jennifer A., Faul, Jessica D., Hu, Yao, Haessler, Jeffrey W., Fornage, Myriam, Kooperberg, Charles, Perry, James A., Hong, Charles C., Cole, John W., and Pugh, Elizabeth
- Subjects
ISCHEMIC stroke ,GENOME-wide association studies ,GENETIC variation ,ABO blood group system - Abstract
Recent genome wide association studies have identified 89 common genetic variants robustly associated with ischemic stroke and primarily located in non-coding regions. To evaluate the contribution of coding variants, which are mostly rare, we performed an exome array analysis on 106,101 SNPs for 9721 ischemic stroke cases from the SiGN Consortium, and 12,345 subjects with no history of stroke from the Health Retirement Study and SiGN consortium. We identified 15 coding variants significantly associated with all ischemic stroke at array-wide threshold (i.e., p < 4.7 × 10
−7 ), including two common SNPs in ABO that have previously been associated with stroke. Twelve of the remaining 13 variants were extremely rare in European Caucasians (MAF < 0.1%) and the associations were driven by African American samples. There was no evidence for replication of these associations in either TOPMed Stroke samples (n = 5613 cases) or UK Biobank (n = 5874 stroke cases), although power to replicate was very low given the low allele frequencies of the associated variants and a shortage of samples from diverse ancestries. Our study highlights the need for acquiring large, well-powered diverse cohorts to study rare variants, and the technical challenges using array-based genotyping technologies for rare variant genotyping. [ABSTRACT FROM AUTHOR]- Published
- 2023
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21. Return of Chloroquine-Susceptible Falciparum Malaria in Malawi Was a Reexpansion of Diverse Susceptible Parasites
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Laufer, Miriam K., Takala-Harrison, Shannon, Dzinjalamala, Fraction K., Stine, O. Colin, Taylor, Terrie E., and Plowe, Christopher V.
- Published
- 2010
22. Prolonged Colonization with the Methicillin‐Resistant Staphylococcus aureus Strain USA300 among Residents of Extended Care Facilities
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Shurland, Simone M., Stine, O. Colin, Venezia, Richard A., Johnson, Jennifer K., Zhan, Min, Furuno, Jon P., Miller, Ram R., Pelser, Colleen, and Roghmann, Mary‐Claire
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- 2010
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23. Assessment of the 48‐Hour Rule for Identifying Community‐Associated Methicillin‐Resistant Staphylococcus aureus Infection Complicated by Bacteremia
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Kreisel, Kristen, Roghmann, Mary‐Claire, Shardell, Michelle, Stine, O. Colin, Perencevich, Eli, Lesse, Alan, Gordin, Fred, Climo, Michael, and Johnson, J. Kristie
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- 2010
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24. The Role of Patient-to-Patient Transmission in the Acquisition of Imipenem-Resistant Pseudomonas aeruginosa Colonization in the Intensive Care Unit
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Johnson, J. Kristie, Smith, Gwen, Lee, Mary S., Venezia, Richard A., Stine, O. Colin, Nataro, James P., Hsiao, William, and Harris, Anthony D.
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- 2009
25. Colonization Sites of USA300 Methicillin‐Resistant Staphylococcus aureus in Residents of Extended Care Facilities
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Shurland, Simone M., Stine, O. Colin, Venezia, Richard A., Johnson, Jennifer K., Zhan, Min, Furuno, Jon P., Miller, Ram R., Johnson, Tamara, and Roghmann, Mary‐Claire
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- 2009
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26. Molecular concordance of methicillin-resistant Staphylococcus aureusisolates from healthcare workers and patients
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Adediran, Timileyin Y., Hitchcock, Stephanie, Johnson, J. Kristie, Stine, O. Colin, Leekha, Surbhi, Thom, Kerri A., Liang, Yuanyuan, Rasko, David A., and Harris, Anthony D.
- Abstract
AbstractBackground:Methicillin-resistant Staphylococcus aureus(MRSA) is a significant nosocomial pathogen in the ICU. MRSA contamination of healthcare personnel (HCP) gloves and gowns after providing care to patients with MRSA occurs at a rate of 14%–16% in the ICU setting. Little is known about whether the MRSA isolates identified on HCP gown and gloves following patient care activities are the same as MRSA isolates identified as colonizing or infecting the patient.Methods:From a multisite cohort of 388 independent patient MRSA isolates and their corresponding HCP gown and glove isolates, we selected 91 isolates pairs using a probability to proportion size (PPS) sampling method. To determine whether the patient and HCP gown or gloves isolates were genetically similar, we used 5 comparative genomic typing methods: phylogenetic analysis, spatyping, multilocus sequence typing (MLST), large-scale BLAST score ratio (LSBSR), and single-nucleotide variant (SNV) analysis.Results:We identified that 56 (61.5%) of isolate pairs were genetically similar at least by 4 of the methods. Comparably, the spatyping and the LSBSR analyses revealed that >75% of the examined isolate pairs were concordant, with the thresholds established for each analysis.Conclusions:Many of the patient MRSA isolates were genetically similar to those on the HCP gown or gloves following a patient care activity. This finding indicates that the patient is often the primary source of the MRSA isolates transmitted to the HCP, which can potentially be spread to other patients or hospital settings through HCP vectors. These results have important implications because they provide additional evidence for hospitals considering ending the use of contact precautions (gloves and gowns) for MRSA patients.
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- 2023
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27. Genetic variation of Vibrio cholerae during outbreaks, Bangladesh, 2010-2011
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Rashed, Shah M., Azman, Andrew S., Alam, Munirul, Li, Shan, Sack, David A., Morris, Jr., J. Glenn, Longini, Ira, Siddique, Abul Kasem, Iqbal, Anwarul, Huq, Anwar, Colwell, Rita R., Sack, R. Bradley, and Stine, O. Colin
- Subjects
Cholera toxin -- Analysis ,Public health -- Analysis ,Cholera -- Genetic aspects -- Analysis ,Health - Abstract
In many areas of the world, cholera remains a major public health problem; it affects millions of persons each year and causes a substantial number of deaths (1,2). In Bangladesh, [...]
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- 2014
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28. Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study
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Harriott, Andrea M, Dueker, Nicole, Cheng, Yu-Ching, Ryan, Kathleen A, O’Connell, Jeffrey R, Stine, O Colin, McArdle, Patrick F, Wozniak, Marcella A, Stern, Barney J, Mitchell, Braxton D, Kittner, Steven J, and Cole, John W
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- 2013
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29. Bowel preparation for colonoscopy: relevant for the gut’s microbiota?
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Mai, Volker and Stine, O Colin
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- 2015
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30. Contrasting Epidemiology of Cholera in Bangladesh and Africa
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Sack, David A, primary, Debes, Amanda K, additional, Ateudjieu, Jerome, additional, Bwire, Godfrey, additional, Ali, Mohammad, additional, Ngwa, Moise Chi, additional, Mwaba, John, additional, Chilengi, Roma, additional, Orach, Christopher C, additional, Boru, Waqo, additional, Mohamed, Ahmed Abade, additional, Ram, Malathi, additional, George, Christine Marie, additional, and Stine, O Colin, additional
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- 2021
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31. The copy number variation and stroke (CaNVAS) risk and outcome study
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Cole, John W., Adigun, Taiwo, Akinyemi, Rufus, Akpa, Onoja Matthew, Bell, Steven, Chen, Bowang, Jimenez-Conde, Jordi, Lazcano, Uxue, Fernandez-Cadenas, Israel, Fornage, Myriam, Gallego-Fabrega, Cristina, Jern, Christina, Krawczak, Michael, Lindgren, Arne, Markus, Hugh S., Melander, Olle, Owolabi, Mayowa, Schlicht, Kristina, Söderholm, Martin, Srinivasasainagendra, Vinodh, Soriano Tárraga, Carolina, Stenman, Martin, Tiwari, Hemant, Corasaniti, Margaret, Fecteau, Natalie, Guizzardi, Beth, Lopez, Haley, Nguyen, Kevin, Gaynor, Brady, O'Connor, Timothy, Stine, O. Colin, Kittner, Steven J., McArdle, Patrick, Mitchell, Braxton D., Xu, Huichun, Grond-Ginsbach, Caspar, Universitat Autònoma de Barcelona, Cole, John W., Adigun, Taiwo, Akinyemi, Rufus, Akpa, Onoja Matthew, Bell, Steven, Chen, Bowang, Jimenez-Conde, Jordi, Lazcano, Uxue, Fernandez-Cadenas, Israel, Fornage, Myriam, Gallego-Fabrega, Cristina, Jern, Christina, Krawczak, Michael, Lindgren, Arne, Markus, Hugh S., Melander, Olle, Owolabi, Mayowa, Schlicht, Kristina, Söderholm, Martin, Srinivasasainagendra, Vinodh, Soriano Tárraga, Carolina, Stenman, Martin, Tiwari, Hemant, Corasaniti, Margaret, Fecteau, Natalie, Guizzardi, Beth, Lopez, Haley, Nguyen, Kevin, Gaynor, Brady, O'Connor, Timothy, Stine, O. Colin, Kittner, Steven J., McArdle, Patrick, Mitchell, Braxton D., Xu, Huichun, Grond-Ginsbach, Caspar, and Universitat Autònoma de Barcelona
- Abstract
The role of copy number variation (CNV) variation in stroke susceptibility and outcome has yet to be explored. The Copy Number Variation and Stroke (CaNVAS) Risk and Outcome study addresses this knowledge gap. Over 24,500 well-phenotyped IS cases, including IS subtypes, and over 43,500 controls have been identified, all with readily available genotyping on GWAS and exome arrays, with case measures of stroke outcome. To evaluate CNV-associated stroke risk and stroke outcome it is planned to: 1) perform Risk Discovery using several analytic approaches to identify CNVs that are associated with the risk of IS and its subtypes, across the age-, sex- and ethnicity-spectrums; 2) perform Risk Replication and Extension to determine whether the identified stroke-associated CNVs replicate in other ethnically diverse datasets and use biomarker data (e.g. methylation, proteomic, RNA, miRNA, etc.) to evaluate how the identified CNVs exert their effects on stroke risk, and lastly; 3) perform outcome-based Replication and Extension analyses of recent findings demonstrating an inverse relationship between CNV burden and stroke outcome at 3 months (mRS), and then determine the key CNV drivers responsible for these associations using existing biomarker data. The results of an initial CNV evaluation of 50 samples from each participating dataset are presented demonstrating that the existing GWAS and exome chip data are excellent for the planned CNV analyses. Further, some samples will require additional considerations for analysis, however such samples can readily be identified, as demonstrated by a sample demonstrating clonal mosaicism. The CaNVAS study will cost-effectively leverage the numerous advantages of using existing case-control data sets, exploring the relationships between CNV and IS and its subtypes, and outcome at 3 months, in both men and women, in those of African and European-Caucasian descent, this, across the entire adult-age spectrum.
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- 2021
32. Directly Repeated Sequences Associated with Pathogenic Mitochondrial DNA Deletions
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Johns, Donald R., Rutledge, S. Lane, Stine, O. Colin, and Hurko, Orest
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- 1989
33. Additional file 1 of Three transmission events of Vibrio cholerae O1 into Lusaka, Zambia
- Author
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Mwaba, John, Debes, Amanda K., Murt, Kelsey N., Shea, Patrick, Simuyandi, Michelo, Laban, Natasha, Kazimbaya, Katayi, Chisenga, Caroline, Li, Shan, Almeida, Mathieu, Meisel, Jacquelyn S., Shibemba, Aaron, Kantenga, Timothy, Mukonka, Victor, Kwenda, Geoffrey, Sack, David A., Chilengi, Roma, and Stine, O. Colin
- Abstract
Additional file 1 Supplemental Figure 1: Unrooted Phylogram of the Genetic Relatedness of Isolates from Zambia, East Africa and Asia.
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- 2021
- Full Text
- View/download PDF
34. The copy number variation and stroke (CaNVAS) risk and outcome study
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Cole, John W., primary, Adigun, Taiwo, additional, Akinyemi, Rufus, additional, Akpa, Onoja Matthew, additional, Bell, Steven, additional, Chen, Bowang, additional, Jimenez Conde, Jordi, additional, Lazcano Dobao, Uxue, additional, Fernandez, Israel, additional, Fornage, Myriam, additional, Gallego-Fabrega, Cristina, additional, Jern, Christina, additional, Krawczak, Michael, additional, Lindgren, Arne, additional, Markus, Hugh S., additional, Melander, Olle, additional, Owolabi, Mayowa, additional, Schlicht, Kristina, additional, Söderholm, Martin, additional, Srinivasasainagendra, Vinodh, additional, Soriano Tárraga, Carolina, additional, Stenman, Martin, additional, Tiwari, Hemant, additional, Corasaniti, Margaret, additional, Fecteau, Natalie, additional, Guizzardi, Beth, additional, Lopez, Haley, additional, Nguyen, Kevin, additional, Gaynor, Brady, additional, O’Connor, Timothy, additional, Stine, O. Colin, additional, Kittner, Steven J., additional, McArdle, Patrick, additional, Mitchell, Braxton D., additional, Xu, Huichun, additional, and Grond-Ginsbach, Caspar, additional
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- 2021
- Full Text
- View/download PDF
35. Molecular epidemiology of geographically dispersed vibrio cholerae, Kenya, January 2009-May 2010
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Mohamed, Ahmed Abade, Oundo, Joseph, Kariuki, Samuel M., Boga, Hamadi I., Sharif, Shanaz K., Akhwale, Willis, Omolo, Jared, Amwayi, Anyangu S., Mutonga, David, Kareko, David, Njeru, Mercy, Li, Shan, Breiman, Robert F., and Stine, O. Colin
- Subjects
Cholera toxin -- Analysis ,Reservoirs -- Analysis ,Epidemiology -- Analysis ,Cholera -- Genetic aspects -- Analysis ,Health - Abstract
Cholera, caused by the bacterium Vibrio cholerae and characterized by a profuse watery diarrhea, has been a serious public health problem since the first recorded pandemic in 1817. In 2009, [...]
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- 2012
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- View/download PDF
36. Diarrheagenic pathogens in polymicrobial infections
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Lindsay, Brianna, Ramamurthy, T., Gupta, Sourav Sen, Takeda, Yoshifumi, Rajendran, Krishnan, Nair, G. Balakrish, and Stine, O. Colin
- Subjects
Cholera toxin -- Health aspects -- Research ,Diarrhea -- Causes of -- Research -- Patient outcomes ,Pathogenic microorganisms -- Health aspects -- Research ,Health - Abstract
The estimated worldwide death rate from diarrheal diseases is -2.2 million deaths per year (1). Diarrheal infections may be caused by an array of bacterial, viral, or parasitic pathogens. Some [...]
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- 2011
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37. Relatedness of Vibrio cholerae O1/O139 isolates from patients and their household contacts, determined by multilocus variable-number tandem-repeat analysis
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Kendall, Emily A., Chowdhury, Fahima, Begum, Yasmin, Khan, Ashraful I., Li, Shan, Thierer, James H., Bailey, Jason, Kreisel, Kristen, Tacket, Carol O., LaRocque, Regina C., Harris, Jason B., Ryan, Edward T., Qadri, Firdausi, Calderwood, Stephen B., and Stine, O. Colin
- Subjects
Vibrio cholerae -- Genetic aspects ,Biological sciences - Abstract
The genetic relatedness of Vibrio cholerae O1/O139 isolates obtained from 100 patients and 146 of their household contacts in Dhaka, Bangladesh, between 2002 and 2005 was assessed by multilocus variable-number tandem-repeat analysis. Isolate genotypes were analyzed at five loci containing tandem repeats. Across the population, as well as within households, isolates with identical genotypes were clustered in time. Isolates from individuals within the same household were more likely to have similar or identical genotypes than were isolates from different households, but even within a household, isolates from different individuals often had different genotypes. When household contacts were sampled regularly for 3 weeks after the illness of the household index patient, isolates with genotypes related to the index patient appeared in contacts, on average, ~3 clays after the index patient, while isolates with unrelated genotypes appeared in contacts ~6 days after. Limited data revealed that multiple isolates from the same individual collected within days of each other or even from a single stool sample may have identical, similar, or unrelated genotypes as well. Our results demonstrate that genetically related V. cholerae strains cluster in local outbreaks but also suggest that multiple distinct strains of V. cholerae O1 may circulate simultaneously within a household. doi: 10.1128/JB.00698-10
- Published
- 2010
38. Illicit drug use and risk for USA300 methicillin-resistant Staphylococcus aureus infections with bacteremia
- Author
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Kreisel, Kristen M., Johnson, J. Kristie, Stine, O. Colin, Shardell, Michelle D., Perencevich, Eli N., Lesse, Alan J., Gordin, Fred M., Climo, Michael W., and Roghmann, Mary-Claire
- Subjects
Medical centers -- Health aspects ,Staphylococcus aureus -- Health aspects ,Illegal drugs -- Research -- Health aspects ,Drug resistance in microorganisms -- Research -- Development and progression -- Health aspects ,Staphylococcus aureus infections -- Research -- Development and progression -- Health aspects ,Bacteremia -- Research -- Development and progression -- Health aspects ,Drug abuse -- Research -- Development and progression -- Health aspects ,Health - Abstract
Infections caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are in creasing. Outbreaks have been described in a variety of populations, including sports teams, men who have sex with men, prisoners, [...]
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- 2010
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39. Prothrombin G20210A Mutation Is Associated With Young-Onset Stroke: The Genetics of Early-Onset Stroke Study and Meta-Analysis
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Jiang, Baijia, Ryan, Kathleen A., Hamedani, Ali, Cheng, Yuching, Sparks, Mary J., Koontz, Deborah, Bean, Christopher J., Gallagher, Margaret, Hooper, W. Craig, McArdle, Patrick F., O’Connell, Jeffrey R., Stine, O. Colin, Wozniak, Marcella A., Stern, Barney J., Mitchell, Braxton D., Kittner, Steven J., and Cole, John W.
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- 2014
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40. Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
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Jaworek, Thomas, Xu, Huichun, Gaynor, Brady J., Cole, John W., Rannikmae, Kristiina, Stanne, Tara M., Tomppo, Liisa, Abedi, Vida, Amouyel, Philippe, Armstrong, Nicole D., Attia, John, Bell, Steven, Benavente, Oscar R., Boncoraglio, Giorgio B., Butterworth, Adam, Carcel-Marquez, Jara, Chen, Zhengming, Chong, Michael, Cruchaga, Carlos, Cushman, Mary, Danesh, John, Debette, Stéphanie, Duggan, David J., Durda, Jon Peter, Engstrom, Gunnar, Enzinger, Chris, Faul, Jessica D., Fecteau, Natalie S., Fernandez-Cadenas, Israel, Gieger, Christian, Giese, Anne-Katrin, Grewal, Raji P., Grittner, Ulrike, Havulinna, Aki S., Heitsch, Laura, Hochberg, Marc C., Holliday, Elizabeth, Hu, Jie, Ilinca, Andreea, Irvin, Marguerite R., Jackson, Rebecca D., Jacob, Mina A., Rabionet, Raquel, Jimenez-Conde, Jordi, Johnson, Julie A., Kamatani, Yoichiro, Kardia, Sharon L.R., Koido, Masaru, Kubo, Michiaki, Lange, Leslie, Lee, Jin-Moo, Lemmens, Robin, Levi, Christopher R., Li, Jiang, Li, Liming, Lin, Kuang, Lopez, Haley, Luke, Sothear, Maguire, Jane, McArdle, Patrick F., McDonough, Caitrin W., Meschia, James F., Metso, Tiina, Müller-Nurasyid, Martina, O'Connor, Timothy D., O'Donnell, Martin, Peddareddygari, Leema R., Pera, Joanna, Perry, James A., Peters, Annette, Putaala, Jukka, Ray, Debashree, Rexrode, Kathryn, Ribases, Marta, Rosand, Jonathan, Rothwell, Peter M., Rundek, Tatjana, Ryan, Kathleen A., Sacco, Ralph L., Salomaa, Veikko, Sanchez-Mora, Cristina, Schmidt, Reinhold, Sharma, Pankaj, Slowik, Agnieszka, Smith, Jennifer A., Smith, Nicholas L., Wassertheil-Smoller, Sylvia, Söderholm, Martin, Stine, O. Colin, Strbian, Daniel, Sudlow, Cathie L.M., Tatlisumak, Turgut, Terao, Chikashi, Thijs, Vincent, Torres-Aguila, Nuria P., Trégouët, David-Alexandre, Tuladhar, Anil M., Veldink, Jan H., Walters, Robin G., Weir, David R., Woo, Daniel, Worrall, Bradford B., Hong, Charles C., Ross, Owen A., Zand, Ramin, Leeuw, Frank-Erik de, Lindgren, Arne G., Pare, Guillaume, Anderson, Christopher D., Markus, Hugh S., Jern, Christina, Malik, Rainer, Dichgans, Martin, Mitchell, Braxton D., and Kittner, Steven J.
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- 2022
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- View/download PDF
41. Skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus USA300 clone
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Johnson, Jennifer K., Khoie, Tina, Shurland, Simone, Kreisel, Kristen, Stine, O. Colin, and Roghmann, Mary-Claire
- Subjects
Staphylococcus aureus infections -- Health aspects ,Cloning -- Health aspects ,Staphylococcus aureus -- Health aspects - Abstract
Until recently, methicillin-resistant Staphylococcus aureus (MRSA) has caused predominantly healthcare-associated infections. We studied MRSA infections and overall skin and soft tissue infections (SSTIs) in outpatients receiving care at the Baltimore [...]
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- 2007
42. Circulation and Transmission of Clones of Vibrio cholerae During Cholera Outbreaks
- Author
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Stine, O. Colin, primary and Morris, J. Glenn, additional
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- 2013
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43. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
- Author
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Malik, Rainer, Chauhan, Ganesh, Anderson, Christopher D, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie L M, Tanislav, Christian, Tatlisumak, Turgut, Chong, Michael, Taylor, Kent D, Thijs, Vincent N S, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Adams, Hieab H H, Wassertheil-Smoller, Sylvia, Wilson, James G, Wiggins, Kerri L, Yang, Qiong, Yusuf, Salim, Consortium, AFGen, Epidemiology, Cohorts for Heart and Aging Research in Genomic, Pressure, International Genomics of Blood, Consortium, INVENT, STARNET, Ago, Tetsuro, Bis, Joshua C, Pastinen, Tomi, Ruusalepp, Arno, Schadt, Eric E, Koplev, Simon, Björkegren, Johan L M, Codoni, Veronica, Civelek, Mete, Smith, Nicholas L, Trégouët, David A, Almgren, Peter, Christophersen, Ingrid E, Roselli, Carolina, Lubitz, Steven A, Ellinor, Patrick T, Tai, E Shyong, Kooner, Jaspal S, Kato, Norihiro, He, Jiang, van der Harst, Pim, Elliott, Paul, Amouyel, Philippe, Chambers, John C, Takeuchi, Fumihiko, Johnson, Andrew D, Group, BioBank Japan Cooperative Hospital, Consortium, COMPASS, Consortium, EPIC-CVD, Consortium, EPIC-InterAct, Consortium, International Stroke Genetics, Consortium, METASTROKE, Consortium, Neurology Working Group of the CHARGE, Ay, Hakan, Network, NINDS Stroke Genetics, Study, UK Young Lacunar DNA, Consortium, MEGASTROKE, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Longstreth, W. T., Rolfs, Arndt, Bartz, Traci M, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Benavente, Oscar R, Fornage, Myriam, Markus, Hugh S, Howson, Joanna M M, Kamatani, Yoichiro, Debette, Stephanie, Dichgans, Martin, Traylor, Matthew, Sargurupremraj, Muralidharan, Bevan, Steve, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul I W, DeStefano, Anita L, Hoed, Marcel den, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I, Ikram, M Arfan, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei-Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O'Donnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu-Ching, Choi, Seung Hoan, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean-François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, den Hoed, Marcel, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Liu, Yong Mei, Lopez, Oscar L, Makoto, Hirata, Martinez-Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Peddareddygari, Leema Reddy, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano-Tárraga, Carolina, Stanne, Tara, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres-Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles D A, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pathology, Epidemiology, Radiology & Nuclear Medicine, Cardiovascular Centre (CVC), Universitat de Barcelona, Traylor, Matthew [0000-0001-6624-8621], Okada, Yukinori [0000-0002-0311-8472], Rutten-Jacobs, Loes [0000-0003-3223-885X], van der Laan, Sander W [0000-0001-6888-1404], Adams, Hieab HH [0000-0003-3687-2508], Almgren, Peter [0000-0002-0473-0241], Amouyel, Philippe [0000-0001-9088-234X], Correa, Adolfo [0000-0002-9501-600X], Cruchaga, Carlos [0000-0002-0276-2899], den Hoed, Marcel [0000-0001-8081-428X], Gustafsson, Stefan [0000-0001-5894-0351], Havulinna, Aki S [0000-0002-4787-8959], Ikram, M Arfan [0000-0003-0372-8585], Jukema, J Wouter [0000-0002-3246-8359], Kanai, Masahiro [0000-0001-5165-4408], Lewis, Cathryn M [0000-0002-8249-8476], Lin, Wei-Yu [0000-0002-9267-7988], Magnusson, Patrik K [0000-0002-7315-7899], Pulit, Sara L [0000-0002-2502-3669], Wiggins, Kerri L [0000-0003-2749-1279], Yang, Qiong [0000-0002-3658-1375], Schadt, Eric E [0000-0002-7892-8808], Koplev, Simon [0000-0002-8586-5614], Civelek, Mete [0000-0002-8141-0284], Trégouët, David A [0000-0001-9084-7800], Christophersen, Ingrid E [0000-0002-6141-4712], Roselli, Carolina [0000-0001-5267-6756], Ellinor, Patrick T [0000-0002-2067-0533], van der Harst, Pim [0000-0002-2713-686X], Elliott, Paul [0000-0002-7511-5684], Takeuchi, Fumihiko [0000-0003-3185-5661], Jern, Christina [0000-0002-7531-2354], Saleheen, Danish [0000-0001-6193-020X], Kamatani, Yoichiro [0000-0001-8748-5597], Dichgans, Martin [0000-0002-0654-387X], and Apollo - University of Cambridge Repository
- Subjects
Male ,0301 basic medicine ,COMPASS Consortium ,Linkage disequilibrium ,Candidate gene ,UK Young Lacunar DNA Study ,Genome-wide association study ,SEPIA ,Linkage Disequilibrium ,Epigenesis, Genetic ,classification [Stroke] ,International Stroke Genetics Consortium (ISGC) ,0302 clinical medicine ,INDEL Mutation ,HEMORRHAGIC STROKE ,Risk Factors ,Pleiotropy ,Databases, Genetic ,Neurology Working Group of the CHARGE Consortium ,WHITE-MATTER HYPERINTENSITIES ,Gene Regulatory Networks ,Stroke ,Genetics & Heredity ,Genetics ,International Genomics of Blood Pressure (iGEN-BP) Consortium ,physiopathology [Stroke] ,AFGen Consortium ,11 Medical And Health Sciences ,Genomics ,3. Good health ,[MEGASTROKE Consortium] ,ISCHEMIC-STROKE ,VINTAGE ,genetics [Stroke] ,CORONARY-ARTERY-DISEASE ,Medical genetics ,Female ,EPIC-InterAct Consortium ,MEGASTROKE Consortium ,Life Sciences & Biomedicine ,Gens ,medicine.medical_specialty ,SUSCEPTIBILITY LOCI ,STARNET ,INVENT Consortium ,SMALL-VESSEL DISEASE ,Biology ,Polymorphism, Single Nucleotide ,EPIC-CVD Consortium ,Article ,Chromosomes ,HUMAN GENETIC-VARIATION ,NINDS Stroke Genetics Network (SiGN) ,03 medical and health sciences ,ddc:570 ,Genetic variation ,medicine ,Humans ,Genetic Predisposition to Disease ,Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium ,Science & Technology ,Models, Genetic ,COMPLEX TRAITS ,Computational Biology ,06 Biological Sciences ,medicine.disease ,METASTROKE Consortium ,Human genetics ,Cromosomes ,BioBank Japan Cooperative Hospital Group ,Genòmica ,030104 developmental biology ,Genes ,Genetic Loci ,ATRIAL-FIBRILLATION ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,SUDDEN CARDIAC DEATH ,030217 neurology & neurosurgery ,Developmental Biology ,Genome-Wide Association Study - Abstract
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke sub-types. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.
- Published
- 2018
44. Genome sequence of Aeromonas hydrophila ATCC [7966.sup.T]: jack of all trades
- Author
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Seshadri, Rekha, Joseph, Sam W., Chopra, Ashok K., Sha, Jian, Shaw, Jonathan, Graf, Joerg, Haft, Daniel, Wu, Martin, Ren, Qinghu, Rosovitz, M.J., Madupu, Ramana, Tallon, Luke, Kim, Mary, Jin, Shaohua, Vuong, Hue, Stine, O. Colin, Ali, Afsar, Horneman, Amy J., and Heidelberg, John F.
- Subjects
Virulence (Microbiology) -- Research ,Genetic markers -- Research ,Genetic research ,Biological sciences - Abstract
The complete genome of Aeromonas hydrophila ATCC [7966.sup.T] was sequenced. Aeromonas, a ubiquitous waterborne bacterium, has been placed by the Environmental Protection Agency on the Contaminant Candidate List because of its potential to cause human disease. The 4.7-Mb genome of this emerging pathogen shows a physiologically adroit organism with broad metabolic capabilities and considerable virulence potential. A large array of virulence genes, including some identified in clinical isolates of Aeromonas spp. or Vibrio spp., may confer upon this organism the ability to infect a wide range of hosts. However, two recognized virulence markers, a type III secretion system and a lateral flagellum, that are reported in other A. hydrophila strains are not identified in the sequenced isolate, ATCC [7966.sup.T]. Given the ubiquity and free-living lifestyle of this organism, there is relatively little evidence of fluidity in terms of mobile elements in the genome of this particular strain. Notable aspects of the metabolic repertoire of A. hydrophila include dissimilatory sulfate reduction and resistance mechanisms (such as thiopurine reductase, arsenate reductase, and phosphonate degradation enzymes) against toxic compounds encountered in polluted waters. These enzymes may have bioremediative as well as industrial potential. Thus, the A. hydrophila genome sequence provides valuable insights into its ability to flourish in both aquatic and host environments.
- Published
- 2006
45. Targeted gown and glove use to prevent Staphylococcus aureus acquisition in community-based nursing homes: A pilot study
- Author
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Lydecker, Alison D., primary, Osei, Patience A., additional, Pineles, Lisa, additional, Johnson, J. Kristie, additional, Meisel, Jacquelyn, additional, Stine, O. Colin, additional, Magder, Laurence, additional, Gurses, Ayse P., additional, Hebden, Joan, additional, Oruc, Cagla, additional, Mody, Lona, additional, Jacobs Slifka, Kara, additional, Stone, Nimalie D., additional, and Roghmann, Mary-Claire, additional
- Published
- 2020
- Full Text
- View/download PDF
46. Molecular epidemiology of O139 vibrio cholerae: mutation, lateral gene transfer, and founder flush. (Research)
- Author
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Garg, Pallavi, Aydanian, Antonia, Smith, David, American novelist, Morris, J. Glenn, Jr., Nair, G. Balakrish, and Stine, O. Colin
- Subjects
Vibrio cholerae -- Genetic aspects - Abstract
Vibrio cholerae in O-group 139 was first isolated in 1992 and by 1993 had been found throughout the Indian subcontinent. This epidemic expansion probably resulted from a single source after [...]
- Published
- 2003
47. Linkage of prostate cancer susceptibility loci to chromosome 1
- Author
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Xu, Jianfeng, Zheng, Siqun L., Chang, Bao-li, Smith, Jeffrey R., Carpten, John D., Stine, O. Colin, Isaacs, Sarah D., Wiley, Kathy E., Henning, Lauren, Ewing, Charles, Bujnovszky, Piroska, Bleeker, Eugene R., Walsh, Patrick C., Trent, Jeffrey M., Meyers, Deborah A., and Isaacs, William B.
- Published
- 2001
- Full Text
- View/download PDF
48. Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia
- Author
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Fleisher, A Steven, Esteller, Manel, Tamura, Gen, Rashid, Asma, Stine, O Colin, Yin, Jing, Zou, Tong-Tong, Abraham, John M, Kong, Dehe, Nishizuka, Satoshi, James, Stephen P, Wilson, Keith T, Herman, James G, and Meltzer, Stephen J
- Published
- 2001
- Full Text
- View/download PDF
49. Vibrio cholerae O1 El Tor and O139 bengal strains carrying [ctxB.sup.ET], Bangladesh
- Author
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Rashed, Shah M., Iqbal, Anwarul, Mannan, Shahnewaj B., Islam, Tarequl, Rashid, Mahamud-ur, Johura, Fatema-tuz, Watanabe, Haruo, Hasan, Nur A., Huq, Anwar, Stine, O. Colin, Sack, R. Bradley, Colwell, Rita R., and Alam, Munirul
- Subjects
Bangladesh -- Health aspects ,Vibrio cholerae -- Genetic aspects ,Health - Abstract
To the Editor: Cholera, caused by Vibrio cholerae, continues to affect millions of persons in disease-endemic areas where safe drinking water is scarce and sanitation is poor. Of 7 cholera [...]
- Published
- 2013
- Full Text
- View/download PDF
50. Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes
- Author
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Wonodi, Ikwunga, Stine, O. Colin, Sathyasaikumar, Korrapati V., Roberts, Rosalinda C., Mitchell, Braxton D., Hong, L. Elliot, Kajii, Yasushi, Thaker, Gunvant K., and Schwarcz, Robert
- Published
- 2011
- Full Text
- View/download PDF
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