Skip to search
Skip to main content
Back to Search
Start Over
Stroke genetics informs drug discovery and risk prediction across ancestries
Authors :
Mishra, Aniket Malik, Rainer Hachiya, Tsuyoshi Jurgenson, Tuuli Namba, Shinichi Posner, Daniel C Kamanu, Frederick K Koido, Masaru Le Grand, Quentin Shi, Mingyang He, Yunye Georgakis, Marios K Caro, Ilana Krebs, Kristi Liaw, Yi-Ching Vaura, Felix C Lin, Kuang Winsvold, Bendik Slagsvold Srinivasasainagendra, Vinodh Parodi, Livia Bae, Hee-Joon Chauhan, Ganesh Chong, Michael R Tomppo, Liisa Akinyemi, Rufus Roshchupkin, Gennady V Habib, Naomi Jee, Yon Ho Thomassen, Jesper Qvist Abedi, Vida Carcel-Marquez, Jara Nygaard, Marianne Leonard, Hampton L Yang, Chaojie Yonova-Doing, Ekaterina Knol, Maria J Lewis, Adam J Judy, Renae L Ago, Tetsuro Amouyel, Philippe Armstrong, Nicole D Bakker, Mark K Bartz, Traci M Bennett, David A Bis, Joshua C Bordes, Constance Borte, Sigrid Cain, Anael Ridker, Paul M Cho, Kelly Chen, Zhengming Cruchaga, Carlos Cole, John W de Jager, Phil L de Cid, Rafael Endres, Matthias Ferreira, Leslie E Geerlings, Mirjam I Gasca, Natalie C Gudnason, Vilmundur Hata, Jun He, Jing Heath, Alicia K Ho, Yuk-Lam Havulinna, Aki S Hopewell, Jemma C Hyacinth, Hyacinth I Inouye, Michael Jacob, Mina A Jeon, Christina E Jern, Christina Kamouchi, Masahiro Keene, Keith L Kitazono, Takanari Kittner, Steven J Konuma, Takahiro Kumar, Amit Lacaze, Paul Launer, Lenore J Lee, Keon-Joo Lepik, Kaido Li, Jiang Li, Liming Manichaikul, Ani Markus, Hugh S Marston, Nicholas A Meitinger, Thomas Mitchell, Braxton D Montellano, Felipe A Morisaki, Takayuki Mosley, Thomas H Nalls, Mike A Nordestgaard, Borge G O'Donnell, Martin J Okada, Yukinori Onland-Moret, N Charlotte Ovbiagele, Bruce Peters, Annette Psaty, Bruce M Rich, Stephen S Rosand, Jonathan Sabatine, Marc S Sacco, Ralph L Saleheen, Danish Sandset, Else Charlotte Salomaa, Veikko Sargurupremraj, Muralidharan Sasaki, Makoto Satizabal, Claudia L Schmidt, Carsten O Shimizu, Atsushi Smith, Nicholas L Sloane, Kelly L Sutoh, Yoichi Sun, Yan V Tanno, Kozo Tiedt, Steffen Tatlisumak, Turgut Torres-Aguila, Nuria P Tiwari, Hemant K Tregouet, David-Alexandre Trompet, Stella Tuladhar, Anil Man Tybjaerg-Hansen, Anne van Vugt, Marion Vibo, Riina Verma, Shefali S Wiggins, Kerri L Wennberg, Patrik Woo, Daniel Wilson, Peter WF Xu, Huichun Yang, Qiong Yoon, Kyungheon Lee, Jin-Moo Cheng, Yu-Ching Meschia, James F Chen, Wei Min Sale, Michele M Zonderman, Alan B Evans, Michele K Wilson, James G Correa, Adolfo Traylor, Matthew Lewis, Cathryn M Carty, Cara L Reiner, Alexander Haessler, Jeffrey Langefeld, Carl D Gottesman, Rebecca F Yaffe, Kristine Liu, Yong Mei Kooperberg, Charles Lange, Leslie A Furie, Karen L Arnett, Donna K Benavente, Oscar R Grewal, Raji P Peddareddygari, Leema Reddy Hveem, Kristian Lindstrom, Sara Wang, Lu Smith, Erin N Gordon, William van Hylckama Vlieg, Astrid de Andrade, Mariza Brody, Jennifer A Pattee, Jack W Brumpton, Ben M Suchon, Pierre Chen, Ming-Huei Frazer, Kelly A Turman, Constance Germain, Marine MacDonald, James Braekkan, Sigrid K Armasu, Sebastian M Pankratz, Nathan Jackson, Rebecca D Nielsen, Jonas B Giulianini, Franco Puurunen, Marja K Ibrahim, Manal Heckbert, Susan R Bammler, Theo K McCauley, Bryan M Taylor, Kent D Pankow, James S Reiner, Alexander P Gabrielsen, Maiken E Deleuze, Jean-Francois O'Donnell, Chris J Kim, Jihye McKnight, Barbara Kraft, Peter Hansen, John-Bjarne Rosendaal, Frits R Heit, John A Tang, Weihong Morange, Pierre-Emmanuel Johnson, Andrew D Kabrhel, Christopher van Dijk, Ewoud J Koudstaal, Peter J Luijckx, Gert-Jan Nederkoorn, Paul J van Oostenbrugge, Robert J Visser, Marieke C Wermer, Marieke JH Kappelle, L Jaap Esko, Tonu Metspalu, Andres Magi, Reedik Nelis, Mari Irvin, Marguerite R de Leeuw, Frank-Erik Levi, Christopher R Maguire, Jane Jimenez-Conde, Jordi Sharma, Pankaj Sudlow, Cathie LM Rannikmae, Kristiina Schmidt, Reinhold Slowik, Agnieszka Pera, Joanna Thijs, Vincent NS Lindgren, Arne G Ilinca, Andreea Melander, Olle Engstrom, Gunnar Rexrode, Kathryn M Rothwell, Peter M Stanne, Tara M Johnson, Julie A Danesh, John Butterworth, Adam S Heitsch, Laura Boncoraglio, Giorgio B Kubo, Michiaki Pezzini, Alessandro Rolfs, Arndt Giese, Anne-Katrin Weir, David Ross, Owen A Lemmons, Robin Soderholm, Martin Cushman, Mary Jood, Katarina McDonough, Caitrin W Bell, Steven Linkohr, Birgit Lee, Tsong-Hai Putaala, Jukka Anderson, Christopher D Lopez, Oscar L Jian, Xueqiu Schminke, Ulf Cullell, Natalia Delgado, Pilar Ibanez, Laura Krupinski, Jerzy Lioutas, Vasileios Matsuda, Koichi Montaner, Joan Muino, Elena Roquer, Jaume Sarnowski, Chloe Sattar, Naveed Sibolt, Gerli Teumer, Alexander Rutten-Jacobs, Loes Kanai, Masahiro Gretarsdottir, Solveig Rost, Natalia S Yusuf, Salim Almgren, Peter Ay, Hakan Bevan, Steve Brown, Robert D Carrera, Caty Buring, Julie E Chen, Wei-Min Cotlarciuc, Ioana de Bakker, Paul IW DeStefano, Anita L den Hoed, Marcel Duan, Qing Engelter, Stefan T Falcone, Guido J Gustafsson, Stefan Hassan, Ahamad Holliday, Elizabeth G Howard, George Hsu, Fang-Chi Ingelsson, Erik Harris, Tamara B Kissela, Brett M Kleindorfer, Dawn O Langenberg, Claudia Lemmens, Robin Leys, Didier Lin, Wei-Yu Lorentzen, Erik Magnusson, Patrik K McArdle, Patrick F Pulit, Sara L Rice, Kenneth Sakaue, Saori Sapkota, Bishwa R Tanislav, Christian Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tzourio, Christophe van Duijn, Cornelia M Walters, Matthew Wareham, Nicholas J Amin, Najaf Aparicio, Hugo J Attia, John Beiser, Alexa S Berr, Claudine Bustamante, Mariana Caso, Valeria Choi, Seung Hoan Chowhan, Ayesha Dartigues, Jean-Francois Delavaran, Hossein Dorr, Marcus Ford, Ian Gurpreet, Wander S Hamsten, Anders Hozawa, Atsushi Ingelsson, Martin Iwasaki, Motoki Kaffashian, Sara Kalra, Lalit Kjartansson, Olafur Kloss, Manja Labovitz, Daniel L Laurie, Cathy C Li, Linxin Lind, Lars Lindgren, Cecilia M Makoto, Hirata Minegishi, Naoko Morris, Andrew P Muller-Nurasyid, Martina Norrving, Bo Ogishima, Soichi Parati, Eugenio A Pedersen, Nancy L Perola, Markus Jousilahti, Pekka Pileggi, Silvana Rabionet, Raquel Riba-Llena, Iolanda Ribases, Marta Romero, Jose R Rudd, Anthony G Sarin, Antti-Pekka Sarju, Ralhan Satoh, Mamoru Sawada, Norie Sigurdsson, Asgeir Smith, Albert Stine, O Colin Stott, David J Strauch, Konstantin Takai, Takako Tanaka, Hideo Touze, Emmanuel Tsugane, Shoichiro Uitterlinden, Andre G Valdimarsson, Einar M van der Lee, Sven J Wakai, Kenji Williams, Stephen R Wolfe, Charles DA Wong, Quenna Yamaji, Taiki Sanghera, Dharambir K Stefansson, Kari Martinez-Majander, Nicolas Sobue, Kenji Soriano-Tarraga, Carolina Volzke, Henry Akpa, Onoja Sarfo, Fred S Akpalu, Albert Obiako, Reginald Wahab, Kolawole Osaigbovo, Godwin Owolabi, Lukman Komolafe, Morenikeji Jenkins, Carolyn Arulogun, Oyedunni Ogbole, Godwin Adeoye, Abiodun M Akinyemi, Joshua Agunloye, Atinuke Fakunle, Adekunle G Uvere, Ezinne Olalere, Abimbola Adebajo, Olayinka J Chen, Junshi Clarke, Robert Collins, Rory Guo, Yu Wang, Chen Lv, Jun Peto, Richard Chen, Yiping Fairhurst-Hunter, Zammy Hill, Michael Pozarickij, Alfred Schmidt, Dan Stevens, Becky Turnbull, Iain Yu, Canqing Nagai, Akiko Murakami, Yoishinori Shiroma, Eric J Sigurdsson, Sigurdur Ghanbari, Mohsen Boerwinkle, Eric Fongang, Bernard Wang, Ruiqi Ikram, Mohammad K Volker, Uwe de Laat, Karlijn F van Norden, Anouk GW de Kort, Paul L Vermeer, Sarah E Brouwers, Paul JAM Gons, Rob AR den Heijer, Tom van Dijk, Gert W van Rooij, Frank GW Aamodt, Anne H Skogholt, Anne H Willer, Cristen J Heuch, Ingrid Hagen, Knut Fritsche, Lars G Pedersen, Linda M Ellekjaer, Hanne Zhou, Wei Martinsen, Amy E Kristoffersen, Espen S Thomas, Laurent F Kleinschnitz, Christoph Frantz, Stefan Ungethum, Kathrin Gallego-Fabrega, Cristina Lledos, Miquel Llucia-Carol, Laia Sobrino, Tomas Campos, Francisco Castillo, Jose Freijo, Marimar Arenillas, Juan Francisco Obach, Victor Alvarez-Sabin, Jose Molina, Carlos A Ribo, Marc Munoz-Narbona, Lucia Lopez-Cancio, Elena Millan, Monica Diaz-Navarro, Rosa Vives-Bauza, Cristofol Serrano-Heras, Gemma Segura, Tomas Dhar, Rajat Delgado-Mederos, Raquel Prats-Sanchez, Luis Camps-Renom, Pol Blay, Natalia Sumoy, Lauro Marti-Fabregas, Joan Schnohr, Peter Jensen, Gorm B Benn, Marianne Afzal, Shoaib Kamstrup, Pia R van Setten, Jessica van der Laan, Sander W Vonk, Jet MJ Kim, Bong-Jo Curtze, Sami Tiainen, Marjaana Kinnunen, Janne Menon, Vilas Sung, Yun Ju Yang, Chengran Saillour-Glenisson, Florence Gravel, Simon Millwood, Iona Y Gieger, Christian Ninomiya, Toshiharu Grabe, Hans J Jukema, J Wouter Rissanen, Ina L Strbian, Daniel Kim, Young Jin Chen, Pei-Hsin Mayerhofer, Ernst Howson, Joanna MM Adams, Hieab Wassertheil-Smoller, Sylvia Christensen, Kaare Ikram, Mohammad A Rundek, Tatjana Worrall, Bradford B Lathrop, G Mark Riaz, Moeen Simonsick, Eleanor M Korv, Janika Franca, Paulo HC Zand, Ramin Prasad, Kameshwar Frikke-Schmidt, Ruth Liman, Thomas Haeusler, Karl Georg Ruigrok, Ynte M Heuschmann, Peter Ulrich Longstreth, WT Jung, Keum Ji Bastarache, Lisa Pare, Guillaume Damrauer, Scott M Chasman, Daniel I Rotter, Jerome I Zwart, John-Anker Niiranen, Teemu J Fornage, Myriam Liaw, Yung-Po Seshadri, Sudha Fernandez-Cadenas, Israel Walters, Robin G Ruff, Christian T Owolabi, Mayowa O Huffman, Jennifer E Milani, Lili Kamatani, Yoichiro Dichgans, Martin Debette, Stephanie Mishra, Aniket Malik, Rainer Hachiya, Tsuyoshi Jurgenson, Tuuli Namba, Shinichi Posner, Daniel C Kamanu, Frederick K Koido, Masaru Le Grand, Quentin Shi, Mingyang He, Yunye Georgakis, Marios K Caro, Ilana Krebs, Kristi Liaw, Yi-Ching Vaura, Felix C Lin, Kuang Winsvold, Bendik Slagsvold Srinivasasainagendra, Vinodh Parodi, Livia Bae, Hee-Joon Chauhan, Ganesh Chong, Michael R Tomppo, Liisa Akinyemi, Rufus Roshchupkin, Gennady V Habib, Naomi Jee, Yon Ho Thomassen, Jesper Qvist Abedi, Vida Carcel-Marquez, Jara Nygaard, Marianne Leonard, Hampton L Yang, Chaojie Yonova-Doing, Ekaterina Knol, Maria J Lewis, Adam J Judy, Renae L Ago, Tetsuro Amouyel, Philippe Armstrong, Nicole D Bakker, Mark K Bartz, Traci M Bennett, David A Bis, Joshua C Bordes, Constance Borte, Sigrid Cain, Anael Ridker, Paul M Cho, Kelly Chen, Zhengming Cruchaga, Carlos Cole, John W de Jager, Phil L de Cid, Rafael Endres, Matthias Ferreira, Leslie E Geerlings, Mirjam I Gasca, Natalie C Gudnason, Vilmundur Hata, Jun He, Jing Heath, Alicia K Ho, Yuk-Lam Havulinna, Aki S Hopewell, Jemma C Hyacinth, Hyacinth I Inouye, Michael Jacob, Mina A Jeon, Christina E Jern, Christina Kamouchi, Masahiro Keene, Keith L Kitazono, Takanari Kittner, Steven J Konuma, Takahiro Kumar, Amit Lacaze, Paul Launer, Lenore J Lee, Keon-Joo Lepik, Kaido Li, Jiang Li, Liming Manichaikul, Ani Markus, Hugh S Marston, Nicholas A Meitinger, Thomas Mitchell, Braxton D Montellano, Felipe A Morisaki, Takayuki Mosley, Thomas H Nalls, Mike A Nordestgaard, Borge G O'Donnell, Martin J Okada, Yukinori Onland-Moret, N Charlotte Ovbiagele, Bruce Peters, Annette Psaty, Bruce M Rich, Stephen S Rosand, Jonathan Sabatine, Marc S Sacco, Ralph L Saleheen, Danish Sandset, Else Charlotte Salomaa, Veikko Sargurupremraj, Muralidharan Sasaki, Makoto Satizabal, Claudia L Schmidt, Carsten O Shimizu, Atsushi Smith, Nicholas L Sloane, Kelly L Sutoh, Yoichi Sun, Yan V Tanno, Kozo Tiedt, Steffen Tatlisumak, Turgut Torres-Aguila, Nuria P Tiwari, Hemant K Tregouet, David-Alexandre Trompet, Stella Tuladhar, Anil Man Tybjaerg-Hansen, Anne van Vugt, Marion Vibo, Riina Verma, Shefali S Wiggins, Kerri L Wennberg, Patrik Woo, Daniel Wilson, Peter WF Xu, Huichun Yang, Qiong Yoon, Kyungheon Lee, Jin-Moo Cheng, Yu-Ching Meschia, James F Chen, Wei Min Sale, Michele M Zonderman, Alan B Evans, Michele K Wilson, James G Correa, Adolfo Traylor, Matthew Lewis, Cathryn M Carty, Cara L Reiner, Alexander Haessler, Jeffrey Langefeld, Carl D Gottesman, Rebecca F Yaffe, Kristine Liu, Yong Mei Kooperberg, Charles Lange, Leslie A Furie, Karen L Arnett, Donna K Benavente, Oscar R Grewal, Raji P Peddareddygari, Leema Reddy Hveem, Kristian Lindstrom, Sara Wang, Lu Smith, Erin N Gordon, William van Hylckama Vlieg, Astrid de Andrade, Mariza Brody, Jennifer A Pattee, Jack W Brumpton, Ben M Suchon, Pierre Chen, Ming-Huei Frazer, Kelly A Turman, Constance Germain, Marine MacDonald, James Braekkan, Sigrid K Armasu, Sebastian M Pankratz, Nathan Jackson, Rebecca D Nielsen, Jonas B Giulianini, Franco Puurunen, Marja K Ibrahim, Manal Heckbert, Susan R Bammler, Theo K McCauley, Bryan M Taylor, Kent D Pankow, James S Reiner, Alexander P Gabrielsen, Maiken E Deleuze, Jean-Francois O'Donnell, Chris J Kim, Jihye McKnight, Barbara Kraft, Peter Hansen, John-Bjarne Rosendaal, Frits R Heit, John A Tang, Weihong Morange, Pierre-Emmanuel Johnson, Andrew D Kabrhel, Christopher van Dijk, Ewoud J Koudstaal, Peter J Luijckx, Gert-Jan Nederkoorn, Paul J van Oostenbrugge, Robert J Visser, Marieke C Wermer, Marieke JH Kappelle, L Jaap Esko, Tonu Metspalu, Andres Magi, Reedik Nelis, Mari Irvin, Marguerite R de Leeuw, Frank-Erik Levi, Christopher R Maguire, Jane Jimenez-Conde, Jordi Sharma, Pankaj Sudlow, Cathie LM Rannikmae, Kristiina Schmidt, Reinhold Slowik, Agnieszka Pera, Joanna Thijs, Vincent NS Lindgren, Arne G Ilinca, Andreea Melander, Olle Engstrom, Gunnar Rexrode, Kathryn M Rothwell, Peter M Stanne, Tara M Johnson, Julie A Danesh, John Butterworth, Adam S Heitsch, Laura Boncoraglio, Giorgio B Kubo, Michiaki Pezzini, Alessandro Rolfs, Arndt Giese, Anne-Katrin Weir, David Ross, Owen A Lemmons, Robin Soderholm, Martin Cushman, Mary Jood, Katarina McDonough, Caitrin W Bell, Steven Linkohr, Birgit Lee, Tsong-Hai Putaala, Jukka Anderson, Christopher D Lopez, Oscar L Jian, Xueqiu Schminke, Ulf Cullell, Natalia Delgado, Pilar Ibanez, Laura Krupinski, Jerzy Lioutas, Vasileios Matsuda, Koichi Montaner, Joan Muino, Elena Roquer, Jaume Sarnowski, Chloe Sattar, Naveed Sibolt, Gerli Teumer, Alexander Rutten-Jacobs, Loes Kanai, Masahiro Gretarsdottir, Solveig Rost, Natalia S Yusuf, Salim Almgren, Peter Ay, Hakan Bevan, Steve Brown, Robert D Carrera, Caty Buring, Julie E Chen, Wei-Min Cotlarciuc, Ioana de Bakker, Paul IW DeStefano, Anita L den Hoed, Marcel Duan, Qing Engelter, Stefan T Falcone, Guido J Gustafsson, Stefan Hassan, Ahamad Holliday, Elizabeth G Howard, George Hsu, Fang-Chi Ingelsson, Erik Harris, Tamara B Kissela, Brett M Kleindorfer, Dawn O Langenberg, Claudia Lemmens, Robin Leys, Didier Lin, Wei-Yu Lorentzen, Erik Magnusson, Patrik K McArdle, Patrick F Pulit, Sara L Rice, Kenneth Sakaue, Saori Sapkota, Bishwa R Tanislav, Christian Thorleifsson, Gudmar Thorsteinsdottir, Unnur Tzourio, Christophe van Duijn, Cornelia M Walters, Matthew Wareham, Nicholas J Amin, Najaf Aparicio, Hugo J Attia, John Beiser, Alexa S Berr, Claudine Bustamante, Mariana Caso, Valeria Choi, Seung Hoan Chowhan, Ayesha Dartigues, Jean-Francois Delavaran, Hossein Dorr, Marcus Ford, Ian Gurpreet, Wander S Hamsten, Anders Hozawa, Atsushi Ingelsson, Martin Iwasaki, Motoki Kaffashian, Sara Kalra, Lalit Kjartansson, Olafur Kloss, Manja Labovitz, Daniel L Laurie, Cathy C Li, Linxin Lind, Lars Lindgren, Cecilia M Makoto, Hirata Minegishi, Naoko Morris, Andrew P Muller-Nurasyid, Martina Norrving, Bo Ogishima, Soichi Parati, Eugenio A Pedersen, Nancy L Perola, Markus Jousilahti, Pekka Pileggi, Silvana Rabionet, Raquel Riba-Llena, Iolanda Ribases, Marta Romero, Jose R Rudd, Anthony G Sarin, Antti-Pekka Sarju, Ralhan Satoh, Mamoru Sawada, Norie Sigurdsson, Asgeir Smith, Albert Stine, O Colin Stott, David J Strauch, Konstantin Takai, Takako Tanaka, Hideo Touze, Emmanuel Tsugane, Shoichiro Uitterlinden, Andre G Valdimarsson, Einar M van der Lee, Sven J Wakai, Kenji Williams, Stephen R Wolfe, Charles DA Wong, Quenna Yamaji, Taiki Sanghera, Dharambir K Stefansson, Kari Martinez-Majander, Nicolas Sobue, Kenji Soriano-Tarraga, Carolina Volzke, Henry Akpa, Onoja Sarfo, Fred S Akpalu, Albert Obiako, Reginald Wahab, Kolawole Osaigbovo, Godwin Owolabi, Lukman Komolafe, Morenikeji Jenkins, Carolyn Arulogun, Oyedunni Ogbole, Godwin Adeoye, Abiodun M Akinyemi, Joshua Agunloye, Atinuke Fakunle, Adekunle G Uvere, Ezinne Olalere, Abimbola Adebajo, Olayinka J Chen, Junshi Clarke, Robert Collins, Rory Guo, Yu Wang, Chen Lv, Jun Peto, Richard Chen, Yiping Fairhurst-Hunter, Zammy Hill, Michael Pozarickij, Alfred Schmidt, Dan Stevens, Becky Turnbull, Iain Yu, Canqing Nagai, Akiko Murakami, Yoishinori Shiroma, Eric J Sigurdsson, Sigurdur Ghanbari, Mohsen Boerwinkle, Eric Fongang, Bernard Wang, Ruiqi Ikram, Mohammad K Volker, Uwe de Laat, Karlijn F van Norden, Anouk GW de Kort, Paul L Vermeer, Sarah E Brouwers, Paul JAM Gons, Rob AR den Heijer, Tom van Dijk, Gert W van Rooij, Frank GW Aamodt, Anne H Skogholt, Anne H Willer, Cristen J Heuch, Ingrid Hagen, Knut Fritsche, Lars G Pedersen, Linda M Ellekjaer, Hanne Zhou, Wei Martinsen, Amy E Kristoffersen, Espen S Thomas, Laurent F Kleinschnitz, Christoph Frantz, Stefan Ungethum, Kathrin Gallego-Fabrega, Cristina Lledos, Miquel Llucia-Carol, Laia Sobrino, Tomas Campos, Francisco Castillo, Jose Freijo, Marimar Arenillas, Juan Francisco Obach, Victor Alvarez-Sabin, Jose Molina, Carlos A Ribo, Marc Munoz-Narbona, Lucia Lopez-Cancio, Elena Millan, Monica Diaz-Navarro, Rosa Vives-Bauza, Cristofol Serrano-Heras, Gemma Segura, Tomas Dhar, Rajat Delgado-Mederos, Raquel Prats-Sanchez, Luis Camps-Renom, Pol Blay, Natalia Sumoy, Lauro Marti-Fabregas, Joan Schnohr, Peter Jensen, Gorm B Benn, Marianne Afzal, Shoaib Kamstrup, Pia R van Setten, Jessica van der Laan, Sander W Vonk, Jet MJ Kim, Bong-Jo Curtze, Sami Tiainen, Marjaana Kinnunen, Janne Menon, Vilas Sung, Yun Ju Yang, Chengran Saillour-Glenisson, Florence Gravel, Simon Millwood, Iona Y Gieger, Christian Ninomiya, Toshiharu Grabe, Hans J Jukema, J Wouter Rissanen, Ina L Strbian, Daniel Kim, Young Jin Chen, Pei-Hsin Mayerhofer, Ernst Howson, Joanna MM Adams, Hieab Wassertheil-Smoller, Sylvia Christensen, Kaare Ikram, Mohammad A Rundek, Tatjana Worrall, Bradford B Lathrop, G Mark Riaz, Moeen Simonsick, Eleanor M Korv, Janika Franca, Paulo HC Zand, Ramin Prasad, Kameshwar Frikke-Schmidt, Ruth Liman, Thomas Haeusler, Karl Georg Ruigrok, Ynte M Heuschmann, Peter Ulrich Longstreth, WT Jung, Keum Ji Bastarache, Lisa Pare, Guillaume Damrauer, Scott M Chasman, Daniel I Rotter, Jerome I Zwart, John-Anker Niiranen, Teemu J Fornage, Myriam Liaw, Yung-Po Seshadri, Sudha Fernandez-Cadenas, Israel Walters, Robin G Ruff, Christian T Owolabi, Mayowa O Huffman, Jennifer E Milani, Lili Kamatani, Yoichiro Dichgans, Martin Debette, Stephanie
Publication Year :
2022
Abstract
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.
Details
Database :
OAIster
Notes :
text, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1367206107
Document Type :
Electronic Resource