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1. Robust joint registration of multiple stains and MRI for multimodal 3D histology reconstruction: Application to the Allen human brain atlas

Author

Casamitjana, Adrià, Lorenzi, Marco, Ferraris, Sebastiano, Peter, Loc, Modat, Marc, Stevens, Allison, Fischl, Bruce, Vercauteren, Tom, and Iglesias, Juan Eugenio

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Joint registration of a stack of 2D histological sections to recover 3D structure (``3D histology reconstruction'') finds application in areas such as atlas building and validation of \emph{in vivo} imaging. Straightforward pairwise registration of neighbouring sections yields smooth reconstructions but has well-known problems such as ``banana effect'' (straightening of curved structures) and ``z-shift'' (drift). While these problems can be alleviated with an external, linearly aligned reference (e.g., Magnetic Resonance (MR) images), registration is often inaccurate due to contrast differences and the strong nonlinear distortion of the tissue, including artefacts such as folds and tears. In this paper, we present a probabilistic model of spatial deformation that yields reconstructions for multiple histological stains that that are jointly smooth, robust to outliers, and follow the reference shape. The model relies on a spanning tree of latent transforms connecting all the sections and slices of the reference volume, and assumes that the registration between any pair of images can be see as a noisy version of the composition of (possibly inverted) latent transforms connecting the two images. Bayesian inference is used to compute the most likely latent transforms given a set of pairwise registrations between image pairs within and across modalities. The framework is used for accurate 3D reconstruction of two stains (Nissl and parvalbumin) from the Allen human brain atlas, showing its benefits on real data with severe distortions. Moreover, we also provide the registration of the reconstructed volume to MNI space, bridging the gaps between two of the most widely used atlases in histology and MRI. The 3D reconstructed volumes and atlas registration can be downloaded from https://openneuro.org/datasets/ds003590. The code is freely available at https://github.com/acasamitjana/3dhirest., Comment: Medical Image Analysis (Accepted on 07/10/2021). 22 pages, 11 figures

Published
2021
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2. Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study

Author

Nolan, Amber L, Petersen, Cathrine, Iacono, Diego, Mac Donald, Christine L, Mukherjee, Pratik, van der Kouwe, Andre, Jain, Sonia, Stevens, Allison, Diamond, Bram R, Wang, Ruopeng, Markowitz, Amy J, Fischl, Bruce, Perl, Daniel P, Manley, Geoffrey T, Keene, C Dirk, Diaz-Arrastia, Ramon, Edlow, Brian L, Adeoye, Opeolu, Badjatia, Neeraj, Boase, Kim, Barber, Jason, Bodien, Yelena, Bullock, M Ross, Chesnut, Randall, Corrigan, John D, Crawford, Karen, Dikmen, Sureyya, Duhaime, Ann-Christine, Ellenbogen, Richard, Feeser, V Ramana, Ferguson, Adam R, Foreman, Brandon, Gardner, Raquel, Gaudette, Etienne, Giacino, Joseph, Goldman, Dana, Gonzalez, Luis, Gopinath, Shankar, Gullapalli, Rao, Hemphill, J Claude, Hotz, Gillian, Korley, Frederick K, Kramer, Joel, Kreitzer, Natalie, Levin, Harvey, Lindsell, Chris, Machamer, Joan, Madden, Christopher, Martin, Alastair, McAllister, Thomas, McCrea, Michael, Merchant, Randall, Nelson, Lindsay, Ngwenya, Laura B, Noel, Florence, Okonkwo, David, Palacios, Eva, Puccio, Ava, Rabinowitz, Miri, Robertson, Claudia, Rosand, Jonathan, Sander, Angelle, Satris, Gabriella, Schnyer, David, Seabury, Seth, Sherer, Mark, Stein, Murray, Taylor, Sabrina, Temkin, Nancy, Toga, Arthur, Valadka, Alex, Vassar, Mary, Vespa, Paul, Wang, Kevin, Yue, John K, Yuh, Esther, and Zafonte, Ross

Subjects
Biomedical Imaging, Physical Injury - Accidents and Adverse Effects, Acquired Cognitive Impairment, Neurosciences, Traumatic Brain Injury (TBI), Traumatic Head and Spine Injury, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Neurological, Brain Injuries, Traumatic, Connectome, Diffusion Tensor Imaging, Humans, Male, Middle Aged, Neural Pathways, contusion, MRI, neuropathology, tractography, traumatic axonal injury, traumatic brain injury, TRACK-TBI Investigators, Clinical Sciences, Neurology & Neurosurgery
Abstract

Diffusion tractography magnetic resonance imaging (MRI) can infer changes in network connectivity in patients with traumatic brain injury (TBI), but the pathological substrates of disconnected tracts have not been well defined because of a lack of high-resolution imaging with histopathological validation. We developed an ex vivo MRI protocol to analyze tract terminations at 750-μm isotropic resolution, followed by histopathological evaluation of white matter pathology, and applied these methods to a 60-year-old man who died 26 days after TBI. Analysis of 74 cerebral hemispheric white matter regions revealed a heterogeneous distribution of tract disruptions. Associated histopathology identified variable white matter injury with patchy deposition of amyloid precursor protein (APP), loss of neurofilament-positive axonal processes, myelin dissolution, astrogliosis, microgliosis, and perivascular hemosiderin-laden macrophages. Multiple linear regression revealed that tract disruption strongly correlated with the density of APP-positive axonal swellings and neurofilament loss. Ex vivo diffusion MRI can detect tract disruptions in the human brain that reflect axonal injury.

Published
2021

3. Joint registration and synthesis using a probabilistic model for alignment of MRI and histological sections

Author

Iglesias, Juan Eugenio, Modat, Marc, Peter, Loic, Stevens, Allison, Annunziata, Roberto, Vercauteren, Tom, Lein, Ed, Fischl, Bruce, and Ourselin, Sebastien

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Nonlinear registration of 2D histological sections with corresponding slices of MRI data is a critical step of 3D histology reconstruction. This task is difficult due to the large differences in image contrast and resolution, as well as the complex nonrigid distortions produced when sectioning the sample and mounting it on the glass slide. It has been shown in brain MRI registration that better spatial alignment across modalities can be obtained by synthesizing one modality from the other and then using intra-modality registration metrics, rather than by using mutual information (MI) as metric. However, such an approach typically requires a database of aligned images from the two modalities, which is very difficult to obtain for histology/MRI. Here, we overcome this limitation with a probabilistic method that simultaneously solves for registration and synthesis directly on the target images, without any training data. In our model, the MRI slice is assumed to be a contrast-warped, spatially deformed version of the histological section. We use approximate Bayesian inference to iteratively refine the probabilistic estimate of the synthesis and the registration, while accounting for each other's uncertainty. Moreover, manually placed landmarks can be seamlessly integrated in the framework for increased performance. Experiments on a synthetic dataset show that, compared with MI, the proposed method makes it possible to use a much more flexible deformation model in the registration to improve its accuracy, without compromising robustness. Moreover, our framework also exploits information in manually placed landmarks more efficiently than MI, since landmarks inform both synthesis and registration - as opposed to registration alone. Finally, we show qualitative results on the public Allen atlas, in which the proposed method provides a clear improvement over MI based registration.

Published
2018
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4. Genetic architecture of subcortical brain structures in 38,851 individuals

Author

Satizabal, Claudia L, Adams, Hieab HH, Hibar, Derrek P, White, Charles C, Knol, Maria J, Stein, Jason L, Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady V, Smith, Albert V, Bis, Joshua C, Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J, Yang, Jingyun, Yanek, Lisa R, Lee, Tom V, Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D, Desrivières, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentería, Miguel E, Kim, Sungeun, Hoehn, David, Armstrong, Nicola J, Chen, Qiang, Holmes, Avram J, den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santiañez, Roberto, Kraemer, Bernd, Håberg, Asta K, Jones, Hannah J, Pike, G Bruce, Stein, Dan J, Stevens, Allison, Bralten, Janita, Vernooij, Meike W, Harris, Tamara B, Filippi, Irina, Witte, A Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H, Becker, James T, Doan, Nhat Trung, Hagenaars, Saskia P, Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M, Ames, David, Goldman, Aaron L, Lee, Phil H, Boomsma, Dorret I, Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M, Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M, Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E, Shin, Jean, Ipser, Jonathan C, Vinke, Louis N, Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K, Aribisala, Benjamin S, and Schmidt, Helena

Subjects
Biological Sciences, Genetics, Brain Disorders, Mental Health, Neurosciences, Human Genome, 2.1 Biological and endogenous factors, Neurological, Adult, Aged, Animals, Brain, Cohort Studies, Drosophila melanogaster, Genetic Variation, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Middle Aged, Neurodevelopmental Disorders, Organ Size, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

Published
2019

6. Forgiveness Education in Fourth- through Eighth-Grade Classrooms: Development and Evaluation of a New Forgiveness Curriculum.

Author

Toussaint, Loren, Kueny, Angela, and Stevens, Allison

Subjects
MIDDLE school education, REQUIRED courses (Education), CHURCH schools, SPRING, CURRICULUM
Abstract

The purpose of this study was to examine the efficacy of a new middle-school-classroom forgiveness curriculum in promoting forgiveness and reducing anger. The students in this study were 153 fourth through eighth graders in three regional parochial schools. The students were assigned to forgiveness education or control groups in the fall semester and reassigned to the opposite group in the spring semester. Before-and-after assessments of forgiveness and anger were collected in both the fall and spring semesters. The quantitative results showed that levels of forgiveness increased as expected in both semesters, but anger did not change in expected ways. The qualitative results showed that the children's conceptualizations of the forgiveness process aligned closely with the core forgiveness curriculum content. The results suggest that meaningful work can be accomplished to promote forgiveness in the middle school classroom using this newly developed, efficient, and effective curriculum that can be implemented by teachers and staff. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Model-Based Refinement of Nonlinear Registrations in 3D Histology Reconstruction

Author

Iglesias, Juan Eugenio, Lorenzi, Marco, Ferraris, Sebastiano, Peter, Loïc, Modat, Marc, Stevens, Allison, Fischl, Bruce, Vercauteren, Tom, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Frangi, Alejandro F., editor, Schnabel, Julia A., editor, Davatzikos, Christos, editor, Alberola-López, Carlos, editor, and Fichtinger, Gabor, editor

Published
2018
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9. Transcriptional landscape of the prenatal human brain.

Author

Miller, Jeremy A, Ding, Song-Lin, Sunkin, Susan M, Smith, Kimberly A, Ng, Lydia, Szafer, Aaron, Ebbert, Amanda, Riley, Zackery L, Royall, Joshua J, Aiona, Kaylynn, Arnold, James M, Bennet, Crissa, Bertagnolli, Darren, Brouner, Krissy, Butler, Stephanie, Caldejon, Shiella, Carey, Anita, Cuhaciyan, Christine, Dalley, Rachel A, Dee, Nick, Dolbeare, Tim A, Facer, Benjamin AC, Feng, David, Fliss, Tim P, Gee, Garrett, Goldy, Jeff, Gourley, Lindsey, Gregor, Benjamin W, Gu, Guangyu, Howard, Robert E, Jochim, Jayson M, Kuan, Chihchau L, Lau, Christopher, Lee, Chang-Kyu, Lee, Felix, Lemon, Tracy A, Lesnar, Phil, McMurray, Bergen, Mastan, Naveed, Mosqueda, Nerick, Naluai-Cecchini, Theresa, Ngo, Nhan-Kiet, Nyhus, Julie, Oldre, Aaron, Olson, Eric, Parente, Jody, Parker, Patrick D, Parry, Sheana E, Stevens, Allison, Pletikos, Mihovil, Reding, Melissa, Roll, Kate, Sandman, David, Sarreal, Melaine, Shapouri, Sheila, Shapovalova, Nadiya V, Shen, Elaine H, Sjoquist, Nathan, Slaughterbeck, Clifford R, Smith, Michael, Sodt, Andy J, Williams, Derric, Zöllei, Lilla, Fischl, Bruce, Gerstein, Mark B, Geschwind, Daniel H, Glass, Ian A, Hawrylycz, Michael J, Hevner, Robert F, Huang, Hao, Jones, Allan R, Knowles, James A, Levitt, Pat, Phillips, John W, Sestan, Nenad, Wohnoutka, Paul, Dang, Chinh, Bernard, Amy, Hohmann, John G, and Lein, Ed S

Subjects
Brain, Neocortex, Fetus, Animals, Humans, Mice, Anatomy, Artistic, Species Specificity, Gene Expression Regulation, Developmental, Conserved Sequence, Gene Regulatory Networks, Atlases as Topic, Transcriptome, Anatomy, Artistic, Gene Expression Regulation, Developmental, General Science & Technology
Abstract

The anatomical and functional architecture of the human brain is mainly determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions. In developing cerebral cortex, transcriptional differences are found between different proliferative and post-mitotic layers, wherein laminar signatures reflect cellular composition and developmental processes. Cytoarchitectural differences between human and mouse have molecular correlates, including species differences in gene expression in subplate, although surprisingly we find minimal differences between the inner and outer subventricular zones even though the outer zone is expanded in humans. Both germinal and post-mitotic cortical layers exhibit fronto-temporal gradients, with particular enrichment in the frontal lobe. Finally, many neurodevelopmental disorder and human-evolution-related genes show patterned expression, potentially underlying unique features of human cortical formation. These data provide a rich, freely-accessible resource for understanding human brain development.

Published
2014

10. Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness.

Author

Edlow, Brian L., Olchanyi, Mark, Freeman, Holly J., Li, Jian, Maffei, Chiara, Snider, Samuel B., Zöllei, Lilla, Iglesias, J. Eugenio, Augustinack, Jean, Bodien, Yelena G., Haynes, Robin L., Greve, Douglas N., Diamond, Bram R., Stevens, Allison, Giacino, Joseph T., Destrieux, Christophe, van der Kouwe, Andre, Brown, Emery N., Folkerth, Rebecca D., and Fischl, Bruce

Subjects
DIFFUSION magnetic resonance imaging, WAKEFULNESS, DEFAULT mode network, MAGNETIC resonance imaging, CONSCIOUSNESS
Abstract

Consciousness is composed of arousal (i.e., wakefulness) and awareness. Substantial progress has been made in mapping the cortical networks that underlie awareness in the human brain, but knowledge about the subcortical networks that sustain arousal in humans is incomplete. Here, we aimed to map the connectivity of a proposed subcortical arousal network that sustains wakefulness in the human brain, analogous to the cortical default mode network (DMN) that has been shown to contribute to awareness. We integrated data from ex vivo diffusion magnetic resonance imaging (MRI) of three human brains, obtained at autopsy from neurologically normal individuals, with immunohistochemical staining of subcortical brain sections. We identified nodes of the proposed default ascending arousal network (dAAN) in the brainstem, hypothalamus, thalamus, and basal forebrain. Deterministic and probabilistic tractography analyses of the ex vivo diffusion MRI data revealed projection, association, and commissural pathways linking dAAN nodes with one another and with DMN nodes. Complementary analyses of in vivo 7-tesla resting-state functional MRI data from the Human Connectome Project identified the dopaminergic ventral tegmental area in the midbrain as a widely connected hub node at the nexus of the subcortical arousal and cortical awareness networks. Our network-based autopsy methods and connectivity data provide a putative neuroanatomic architecture for the integration of arousal and awareness in human consciousness. Editor's summary: Wakefulness is essential for human consciousness, but the brain connections underpinning wakefulness are unclear. Edlow et al. now map a neural network called the default ascending arousal network (dAAN) that they propose sustains human wakefulness. Using three human brains obtained at autopsy, the researchers examined the brains by ex vivo magnetic resonance imaging (MRI) and immunohistochemistry of brain sections. They report that the subcortical dAAN is linked to the cortical default mode network (DMN) that contributes to awareness (another key element of human consciousness). Functional MRI analyses from the Human Connectome Project further revealed a dAAN-DMN connectivity hub within the dopaminergic ventral tegmental area, suggesting how arousal and awareness in human consciousness might be integrated in the human brain. —Orla Smith [ABSTRACT FROM AUTHOR]

Published
2024
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13. Heritability of brain ventricle volume: Converging evidence from inconsistent results

Author

Kremen, William S, Panizzon, Matthew S, Neale, Michael C, Fennema-Notestine, Christine, Prom-Wormley, Elizabeth, Eyler, Lisa T, Stevens, Allison, Franz, Carol E, Lyons, Michael J, Grant, Michael D, Jak, Amy J, Jernigan, Terry L, Xian, Hong, Fischl, Bruce, Thermenos, Heidi W, Seidman, Larry J, Tsuang, Ming T, and Dale, Anders M

Subjects
Biological Psychology, Psychology, Aging, Neurosciences, Prevention, Adolescent, Adult, Aged, Aged, 80 and over, Cerebral Ventricles, Child, Gene-Environment Interaction, Humans, Middle Aged, Organ Size, Sample Size, Twin Studies as Topic, Young Adult, Alzheimer's Disease, Endophenotype, Genetics, Lateral ventricles, Mild cognitive impairment, Structural MRI, Twins, Clinical Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Twin studies generally show great consistency for the heritability of brain structures. Ironically, the lateral ventricles--perhaps the most reliably measured brain regions of interest--are the most inconsistent when it comes to estimating genetic influences on their volume. Heritability estimates in twin studies have ranged from zero to almost 0.80. Here we aggregate heritability estimates from extant twin studies, and we review and reinterpret some of the findings. Based on our revised estimates, we conclude that lateral ventricular volume is indeed heritable. The weighted average heritability of the revised estimates was 0.54. Although accumulated environmental insults might seem most logical as the predominant cause of age-related ventricular expansion, the data strongly suggest that genetic influences on lateral ventricular volume are increasing with age. Genetic influences accounted for 32-35% of the variance in lateral ventricular volume in childhood, but about 75% of the variance in late middle and older age. These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging.

Published
2012

14. Genetic and Environmental Contributions to Regional Cortical Surface Area in Humans: A Magnetic Resonance Imaging Twin Study

Author

Eyler, Lisa T, Prom-Wormley, Elizabeth, Panizzon, Matthew S, Kaup, Allison R, Fennema-Notestine, Christine, Neale, Michael C, Jernigan, Terry L, Fischl, Bruce, Franz, Carol E, Lyons, Michael J, Grant, Michael, Stevens, Allison, Pacheco, Jennifer, Perry, Michele E, Schmitt, J Eric, Seidman, Larry J, Thermenos, Heidi W, Tsuang, Ming T, Chen, Chi-Hua, Thompson, Wesley K, Jak, Amy, Dale, Anders M, and Kremen, William S

Subjects
Biological Psychology, Psychology, Clinical Research, Genetics, Animals, Brain Mapping, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Quantitative Trait, Heritable, Social Environment, cortex, cortical thickness, heritability, Neurosciences, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

Cortical surface area measures appear to be functionally relevant and distinct in etiology, development, and behavioral correlates compared with other size characteristics, such as cortical thickness. Little is known about genetic and environmental influences on individual differences in regional surface area in humans. Using a large sample of adult twins, we determined relative contributions of genes and environment on variations in regional cortical surface area as measured by magnetic resonance imaging before and after adjustment for genetic and environmental influences shared with total cortical surface area. We found high heritability for total surface area and, before adjustment, moderate heritability for regional surface areas. Compared with other lobes, heritability was higher for frontal lobe and lower for medial temporal lobe. After adjustment for total surface area, regionally specific genetic influences were substantially reduced, although still significant in most regions. Unlike other lobes, left frontal heritability remained high after adjustment. Thus, global and regionally specific genetic factors both influence cortical surface areas. These findings are broadly consistent with results from animal studies regarding the evolution and development of cortical patterning and may guide future research into specific environmental and genetic determinants of variation among humans in the surface area of particular regions.

Published
2011

15. Genetic patterns of correlation among subcortical volumes in humans: Results from a magnetic resonance imaging twin study

Author

Eyler, Lisa T, Prom‐Wormley, Elizabeth, Fennema‐Notestine, Christine, Panizzon, Matthew S, Neale, Michael C, Jernigan, Terry L, Fischl, Bruce, Franz, Carol E, Lyons, Michael J, Stevens, Allison, Pacheco, Jennifer, Perry, Michele E, Schmitt, J Eric, Spitzer, Nicholas C, Seidman, Larry J, Thermenos, Heidi W, Tsuang, Ming T, Dale, Anders M, and Kremen, William S

Subjects
Biological Psychology, Psychology, Acquired Cognitive Impairment, Basic Behavioral and Social Science, Neurosciences, Brain Disorders, Behavioral and Social Science, Dementia, Mental Health, Genetics, Aging, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Cerebral Cortex, Gene Expression Regulation, Developmental, Genetic Variation, Humans, Individuality, Male, Middle Aged, Models, Genetic, Twins, behavioral genetics, hippocampus, amygdala, striatum, pallidum, caudate, putamen, thalamus, ventricles, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

Little is known about genetic influences on the volume of subcortical brain structures in adult humans, particularly whether there is regional specificity of genetic effects. Understanding patterns of genetic covariation among volumes of subcortical structures may provide insight into the development of individual differences that have consequences for cognitive and emotional behavior and neuropsychiatric disease liability. We measured the volume of 19 subcortical structures (including brain and ventricular regions) in 404 twins (110 monozygotic and 92 dizygotic pairs) from the Vietnam Era Twin Study of Aging and calculated the degree of genetic correlation among these volumes. We then examined the patterns of genetic correlation through hierarchical cluster analysis and by principal components analysis. We found that a model with four genetic factors best fit the data: a Basal Ganglia/Thalamus factor; a Ventricular factor; a Limbic factor; and a Nucleus Accumbens factor. Homologous regions from each hemisphere loaded on the same factors. The observed patterns of genetic correlation suggest the influence of multiple genetic influences. There is a genetic organization among structures which distinguishes between brain and cerebrospinal fluid spaces and between different subcortical regions. Further study is needed to understand this genetic patterning and whether it reflects influences on early development, functionally dependent patterns of growth or pruning, or regionally specific losses due to genes involved in aging, stress response, or disease.

Published
2011

16. Sustaining wakefulness: Brainstem connectivity in human consciousness

Author

Edlow, Brian L., primary, Olchanyi, Mark, additional, Freeman, Holly J., additional, Li, Jian, additional, Maffei, Chiara, additional, Snider, Samuel B., additional, Zöllei, Lilla, additional, Iglesias, J. Eugenio, additional, Augustinack, Jean, additional, Bodien, Yelena G., additional, Haynes, Robin L., additional, Greve, Douglas N., additional, Diamond, Bram R., additional, Stevens, Allison, additional, Giacino, Joseph T., additional, Destrieux, Christophe, additional, van der Kouwe, Andre, additional, Brown, Emery N., additional, Folkerth, Rebecca D., additional, Fischl, Bruce, additional, and Kinney, Hannah C., additional

Published
2023
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18. 7 Tesla MRI of the ex vivo human brain at 100 micron resolution

Author

Edlow, Brian L., Mareyam, Azma, Horn, Andreas, Polimeni, Jonathan R., Witzel, Thomas, Tisdall, M. Dylan, Augustinack, Jean C., Stockmann, Jason P., Diamond, Bram R., Stevens, Allison, Tirrell, Lee S., Folkerth, Rebecca D., Wald, Lawrence L., Fischl, Bruce, and van der Kouwe, Andre

Published
2019
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21. Rare Adventist Corpora

Author

Stevens, Warren and Stevens, Allison

Subjects
Digital Humanities, Seventh-day Adventist, Ellen G. White, Natural Language Processing
Abstract

Public domain texts for Natural Language Processing and analysis.

Published
2022
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25. Comprehensive cellular‐resolution atlas of the adult human brain

Author

Ding, Song‐Lin, Royall, Joshua J., Sunkin, Susan M., Ng, Lydia, Facer, Benjamin A.C., Lesnar, Phil, Guillozet‐Bongaarts, Angie, McMurray, Bergen, Szafer, Aaron, Dolbeare, Tim A., Stevens, Allison, Tirrell, Lee, Benner, Thomas, Caldejon, Shiella, Dalley, Rachel A., Dee, Nick, Lau, Christopher, Nyhus, Julie, Reding, Melissa, Riley, Zackery L., Sandman, David, Shen, Elaine, van der Kouwe, Andre, Varjabedian, Ani, Write, Michelle, Zollei, Lilla, Dang, Chinh, Knowles, James A., Koch, Christof, Phillips, John W., Sestan, Nenad, Wohnoutka, Paul, Zielke, H. Ronald, Hohmann, John G., Jones, Allan R., Bernard, Amy, Hawrylycz, Michael J., Hof, Patrick R., Fischl, Bruce, and LeinReference, Ed S.

Published
2017
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28. Genetic and environmental influences on the size of specific brain regions in midlife: The VETSA MRI study

Author

Kremen, William S., Prom-Wormley, Elizabeth, Panizzon, Matthew S., Eyler, Lisa T., Fischl, Bruce, Neale, Michael C., Franz, Carol E., Lyons, Michael J., Pacheco, Jennifer, Perry, Michele E., Stevens, Allison, Schmitt, J. Eric, Grant, Michael D., Seidman, Larry J., Thermenos, Heidi W., Tsuang, Ming T., Eisen, Seth A., Dale, Anders M., and Fennema-Notestine, Christine

Published
2010
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31. Predicting the location of entorhinal cortex from MRI

Author

Fischl, Bruce, Stevens, Allison A., Rajendran, Niranjini, Yeo, B.T. Thomas, Greve, Douglas N., Van Leemput, Koen, Polimeni, Jonathan R., Kakunoori, Sita, Buckner, Randy L., Pacheco, Jennifer, Salat, David H., Melcher, Jennifer, Frosch, Matthew P., Hyman, Bradley T., Grant, P. Ellen, Rosen, Bruce R., van der Kouwe, André J.W., Wiggins, Graham C., Wald, Lawrence L., and Augustinack, Jean C.

Published
2009
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34. Female International Students Experiences With Physical Activity on UBC Campus

Author

Stevens, Allison, Larsen, Evangeline, Bailey, Makenna, Kamalian, Sahba, and Marconato, Dante

Abstract

Physical activity (PA) has proven time and time again to have countless positive effects on our health (World Health Organization, 2018). The literature shows that many populations, such as university students, are not engaging in enough PA and therefore are not reaping the benefits (Böke, Mills, Mettler & Heath, 2019). Within the university student population, evidence shows that female international students are a specific subset of this population with some of the lowest PA rates (Lovell et al., 2010). This study aims to understand some of the factors that relate to why this specific population has lower PA participation rates. It also offers evidence-based suggestions as to how these low PA rates can be increased. This mixed methods study looked at common barriers participants face, gaps in programming, and key areas for improvement. This study was conducted with an anonymous Qualtrics survey link that was posted on multiple Facebook groups and pages. Participants were able to complete the survey on their own time. The survey consisted of six questions, both qualitative and quantitative. All participants were individuals who self-identified as female and who had moved from outside of Canada to attend UBC. First, the survey looked specifically at the number of days in a week that participants engaged in PA. Next it looked at how much individuals thought a variety of common barriers, such as financial and accessibility barriers, affected their participation in PA on campus. The final questions of the survey allowed individuals a space to contribute any recommendations they had to improve the PA environment on UBC campus. Results showed that “inclusivity” had the highest average score for barriers. It also yielded many anecdotal responses with important key words such as “unwelcoming” and “too crowded”. These results provided us with evidence that led to the following five recommendations aimed to improve the current PA environment for female international students at UBC. Our first recommendation is that UBC Recreation offers classes in Mandarin and other common foreign languages. This will allow individuals who may speak English as a second language to participate in PA activities in a more comfortable setting. Our second recommendation is that UBC Recreation offers a variety of female only fitness classes. These will address the gender stereotypes that many PA settings have. Our third recommendation is that promotion of UBC Recreation programs be more heavily focused on the beginner and entry-level programs. This will allow students to increase their awareness around programs that are accessible to all abilities. This was an issue highlighted in the data collection. Our fourth recommendation is that UBC residences provide access to personal trainers on-site in the residences. This will allow students easy access to a fitness outlet in a familiar setting. Our final recommendation is that UBC Recreation strives towards building a permanent female-only gym facility. This would allow a safe and comfortable space for females to exercise while also increasing the number of PA facilities on campus. Further research should be done to see how to best implement these recommendations. However they provide a foundation for improvement of the PA environment at UBC. Disclaimer: “UBC SEEDS provides students with the opportunity to share the findings of their studies, as well as their opinions, conclusions and recommendations with the UBC community. The reader should bear in mind that this is a student project/report and is not an official document of UBC. Furthermore readers should bear in mind that these reports may not reflect the current status of activities at UBC. We urge you to contact the research persons mentioned in a report or the SEEDS Coordinator about the current status of the subject matter of a project/report.”

Published
2020
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37. A major blow to Roe

Author

Stevens, Allison

Subjects
Abortion -- Methods, Abortion -- Laws, regulations and rules, Women's rights -- Evaluation, Government regulation, Women's issues/gender studies
Published
2007

38. Genetic architecture of subcortical brain structures in 38,851 individuals

Author

Satizabal, Claudia L., Adams, Hieab H. H., Hibar, Derrek P., White, Charles C., Knol, Maria J., Stein, Jason L., Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady, V, Smith, Albert, V, Bis, Joshua C., Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J., Yang, Jingyun, Yanek, Lisa R., Lee, Tom, V, Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D., Desrivieres, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentera, Miguel E., Kim, Sungeun, Hoehn, David, Armstrong, Nicola J., Chen, Qiang, Holmes, Avram J., den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santianez, Roberto, Kraemer, Bernd, Haberg, Asta K., Jones, Hannah J., Pike, G. Bruce, Stein, Dan J., Stevens, Allison, Bralten, Janita, Vernooij, Meike W., Harris, Tamara B., Filippi, Irina, Witte, A. Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H., Becker, James T., Doan, Nhat Trung, Hagenaars, Saskia P., Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M., Ames, David, Goldman, Aaron L., Lee, Phil H., Boomsma, Dorret, I, Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M., Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M., Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E., Shin, Jean, Ipser, Jonathan C., Vinke, Louis N., Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K., Aribisala, Benjamin S., Schmidt, Helena, Strike, Lachlan T., Cheng, Ching-Yu, Risacher, Shannon L., Puetz, Benno, Fleischman, Debra A., Assareh, Amelia A., Mattay, Venkata S., Buckner, Randy L., Mecocci, Patrizia, Dale, Anders M., Cichon, Sven, Boks, Marco P., Matarin, Mar, Penninx, Brenda W. J. H., Calhoun, Vince D., Chakravarty, M. Mallar, Marquand, Andre F., Macare, Christine, Masouleh, Shahrzad Kharabian, Oosterlaan, Jaap, Amouyel, Philippe, Hegenscheid, Katrin, Rotter, Jerome, I, Schork, Andrew J., Liewald, David C. M., de Zubicaray, Greig, I, Wong, Tien Yin, Shen, Li, Saemann, Philipp G., Brodaty, Henry, Roffman, Joshua L., de Geus, Eco J. C., Tsolaki, Magda, Erk, Susanne, van Eijk, Kristel R., Cavalleri, Gianpiero L., van der Wee, Nic J. A., McIntosh, Andrew M., Gollub, Randy L., Bulayeva, Kazima B., Bernard, Manon, Richards, Jennifer S., Himali, Jayandra J., Loeffler, Markus, Rommelse, Nanda, Hoffmann, Wolfgang, Westlye, Lars T., Hernandez, Maria C. Valdes, Hansell, Narelle K., van Erp, Theo G. M., Wolf, Christiane, Kwok, John B. J., Vellas, Bruno, Heinz, Andreas, Loohuis, Loes M. Olde, Delanty, Norman, Ho, Beng-Choon, Ching, Christopher R. K., Shumskaya, Elena, Singh, Baljeet, Hofman, Albert, van der Meer, Dennis, Homuth, Georg, Psaty, Bruce M., Bastin, Mark E., Montgomery, Grant W., Foroud, Tatiana M., Reppermund, Simone, Hottenga, Jouke-Jan, Simmons, Andrew, Meyer-Lindenberg, Andreas, Cahn, Wiepke, Whelan, Christopher D., van Donkelaar, Marjolein M. J., Yang, Qiong, Hosten, Norbert, Green, Robert C., Thalamuthu, Anbupalam, Mohnke, Sebastian, Pol, Hilleke E. Hulshoff, Lin, Honghuang, Jack, Clifford R., Jr., Schofield, Peter R., Muehleisen, Thomas W., Maillard, Pauline, Potkin, Steven G., Wen, Wei, Fletcher, Evan, Toga, Arthur W., Gruber, Oliver, Huentelman, Matthew, Smith, George Davey, Launer, Lenore J., Nyberg, Lars, Jonsson, Erik G., Crespo-Facorro, Benedicto, Koen, Nastassja, Greve, Douglas N., Uitterlinden, Andre G., Weinberger, Daniel R., Steen, Vidar M., Fedko, Iryna O., Groenewold, Nynke A., Niessen, Wiro J., Toro, Roberto, Tzourio, Christophe, Longstreth, William T., Jr., Ikram, M. Kamran, Smoller, Jordan W., van Tol, Marie-Jose, Sussmann, Jessika E., Paus, Tomas, Lemaitre, Herve, Schroeter, Matthias L., Mazoyer, Bernard, Andreassen, Ole A., Holsboer, Florian, Depondt, Chantal, Veltman, Dick J., Turner, Jessica A., Pausova, Zdenka, Schumann, Gunter, van Rooij, Daan, Djurovic, Srdjan, Deary, Ian J., McMahon, Katie L., Mueller-Myhsok, Bertram, Brouwer, Rachel M., Soininen, Hilkka, Pandolfo, Massimo, Wassink, Thomas H., Cheung, Joshua W., Wolfers, Thomas, Martinot, Jean-Luc, Zwiers, Marcel P., Nauck, Matthias, Melle, Ingrid, Martin, Nicholas G., Kanai, Ryota, Westman, Eric, Kahn, Rene S., Sisodiya, Sanjay M., White, Tonya, Saremi, Arvin, van Bokhoven, Hans, Brunner, Han G., Voelzke, Henry, Wright, Margaret J., van't Ent, Dennis, Noethen, Markus M., Ophoff, Roel A., Buitelaar, Jan K., Fernandez, Guilln, Sachdev, Perminder S., Rietschel, Marcella, van Haren, Neeltje E. M., Fisher, Simon E., Beiser, Alexa S., Francks, Clyde, Saykin, Andrew J., Mather, Karen A., Romanczuk-Seiferth, Nina, Hartman, Catharina A., DeStefano, Anita L., Heslenfeld, Dirk J., Weiner, Michael W., Walter, Henrik, Hoekstra, Pieter J., Nyquist, Paul A., Franke, Barbara, Bennett, David A., Grabe, Hans J., Johnson, Andrew D., Chen, Christopher, van Duijn, Cornelia M., Lopez, Oscar L., Fornage, Myriam, Wardlaw, Joanna M., Schmidt, Reinhold, DeCarli, Charles, De Jager, Philip L., Villringer, Arno, Debette, Stephanie, Gudnason, Vilmundur, Medland, Sarah E., Shulman, Joshua M., Thompson, Paul M., Seshadri, Sudha, Ikram, M. Arfan, Satizabal, Claudia L., Adams, Hieab H. H., Hibar, Derrek P., White, Charles C., Knol, Maria J., Stein, Jason L., Scholz, Markus, Sargurupremraj, Muralidharan, Jahanshad, Neda, Roshchupkin, Gennady, V, Smith, Albert, V, Bis, Joshua C., Jian, Xueqiu, Luciano, Michelle, Hofer, Edith, Teumer, Alexander, van der Lee, Sven J., Yang, Jingyun, Yanek, Lisa R., Lee, Tom, V, Li, Shuo, Hu, Yanhui, Koh, Jia Yu, Eicher, John D., Desrivieres, Sylvane, Arias-Vasquez, Alejandro, Chauhan, Ganesh, Athanasiu, Lavinia, Rentera, Miguel E., Kim, Sungeun, Hoehn, David, Armstrong, Nicola J., Chen, Qiang, Holmes, Avram J., den Braber, Anouk, Kloszewska, Iwona, Andersson, Micael, Espeseth, Thomas, Grimm, Oliver, Abramovic, Lucija, Alhusaini, Saud, Milaneschi, Yuri, Papmeyer, Martina, Axelsson, Tomas, Ehrlich, Stefan, Roiz-Santianez, Roberto, Kraemer, Bernd, Haberg, Asta K., Jones, Hannah J., Pike, G. Bruce, Stein, Dan J., Stevens, Allison, Bralten, Janita, Vernooij, Meike W., Harris, Tamara B., Filippi, Irina, Witte, A. Veronica, Guadalupe, Tulio, Wittfeld, Katharina, Mosley, Thomas H., Becker, James T., Doan, Nhat Trung, Hagenaars, Saskia P., Saba, Yasaman, Cuellar-Partida, Gabriel, Amin, Najaf, Hilal, Saima, Nho, Kwangsik, Mirza-Schreiber, Nazanin, Arfanakis, Konstantinos, Becker, Diane M., Ames, David, Goldman, Aaron L., Lee, Phil H., Boomsma, Dorret, I, Lovestone, Simon, Giddaluru, Sudheer, Le Hellard, Stephanie, Mattheisen, Manuel, Bohlken, Marc M., Kasperaviciute, Dalia, Schmaal, Lianne, Lawrie, Stephen M., Agartz, Ingrid, Walton, Esther, Tordesillas-Gutierrez, Diana, Davies, Gareth E., Shin, Jean, Ipser, Jonathan C., Vinke, Louis N., Hoogman, Martine, Jia, Tianye, Burkhardt, Ralph, Klein, Marieke, Crivello, Fabrice, Janowitz, Deborah, Carmichael, Owen, Haukvik, Unn K., Aribisala, Benjamin S., Schmidt, Helena, Strike, Lachlan T., Cheng, Ching-Yu, Risacher, Shannon L., Puetz, Benno, Fleischman, Debra A., Assareh, Amelia A., Mattay, Venkata S., Buckner, Randy L., Mecocci, Patrizia, Dale, Anders M., Cichon, Sven, Boks, Marco P., Matarin, Mar, Penninx, Brenda W. J. H., Calhoun, Vince D., Chakravarty, M. Mallar, Marquand, Andre F., Macare, Christine, Masouleh, Shahrzad Kharabian, Oosterlaan, Jaap, Amouyel, Philippe, Hegenscheid, Katrin, Rotter, Jerome, I, Schork, Andrew J., Liewald, David C. M., de Zubicaray, Greig, I, Wong, Tien Yin, Shen, Li, Saemann, Philipp G., Brodaty, Henry, Roffman, Joshua L., de Geus, Eco J. C., Tsolaki, Magda, Erk, Susanne, van Eijk, Kristel R., Cavalleri, Gianpiero L., van der Wee, Nic J. A., McIntosh, Andrew M., Gollub, Randy L., Bulayeva, Kazima B., Bernard, Manon, Richards, Jennifer S., Himali, Jayandra J., Loeffler, Markus, Rommelse, Nanda, Hoffmann, Wolfgang, Westlye, Lars T., Hernandez, Maria C. Valdes, Hansell, Narelle K., van Erp, Theo G. M., Wolf, Christiane, Kwok, John B. J., Vellas, Bruno, Heinz, Andreas, Loohuis, Loes M. Olde, Delanty, Norman, Ho, Beng-Choon, Ching, Christopher R. K., Shumskaya, Elena, Singh, Baljeet, Hofman, Albert, van der Meer, Dennis, Homuth, Georg, Psaty, Bruce M., Bastin, Mark E., Montgomery, Grant W., Foroud, Tatiana M., Reppermund, Simone, Hottenga, Jouke-Jan, Simmons, Andrew, Meyer-Lindenberg, Andreas, Cahn, Wiepke, Whelan, Christopher D., van Donkelaar, Marjolein M. J., Yang, Qiong, Hosten, Norbert, Green, Robert C., Thalamuthu, Anbupalam, Mohnke, Sebastian, Pol, Hilleke E. Hulshoff, Lin, Honghuang, Jack, Clifford R., Jr., Schofield, Peter R., Muehleisen, Thomas W., Maillard, Pauline, Potkin, Steven G., Wen, Wei, Fletcher, Evan, Toga, Arthur W., Gruber, Oliver, Huentelman, Matthew, Smith, George Davey, Launer, Lenore J., Nyberg, Lars, Jonsson, Erik G., Crespo-Facorro, Benedicto, Koen, Nastassja, Greve, Douglas N., Uitterlinden, Andre G., Weinberger, Daniel R., Steen, Vidar M., Fedko, Iryna O., Groenewold, Nynke A., Niessen, Wiro J., Toro, Roberto, Tzourio, Christophe, Longstreth, William T., Jr., Ikram, M. Kamran, Smoller, Jordan W., van Tol, Marie-Jose, Sussmann, Jessika E., Paus, Tomas, Lemaitre, Herve, Schroeter, Matthias L., Mazoyer, Bernard, Andreassen, Ole A., Holsboer, Florian, Depondt, Chantal, Veltman, Dick J., Turner, Jessica A., Pausova, Zdenka, Schumann, Gunter, van Rooij, Daan, Djurovic, Srdjan, Deary, Ian J., McMahon, Katie L., Mueller-Myhsok, Bertram, Brouwer, Rachel M., Soininen, Hilkka, Pandolfo, Massimo, Wassink, Thomas H., Cheung, Joshua W., Wolfers, Thomas, Martinot, Jean-Luc, Zwiers, Marcel P., Nauck, Matthias, Melle, Ingrid, Martin, Nicholas G., Kanai, Ryota, Westman, Eric, Kahn, Rene S., Sisodiya, Sanjay M., White, Tonya, Saremi, Arvin, van Bokhoven, Hans, Brunner, Han G., Voelzke, Henry, Wright, Margaret J., van't Ent, Dennis, Noethen, Markus M., Ophoff, Roel A., Buitelaar, Jan K., Fernandez, Guilln, Sachdev, Perminder S., Rietschel, Marcella, van Haren, Neeltje E. M., Fisher, Simon E., Beiser, Alexa S., Francks, Clyde, Saykin, Andrew J., Mather, Karen A., Romanczuk-Seiferth, Nina, Hartman, Catharina A., DeStefano, Anita L., Heslenfeld, Dirk J., Weiner, Michael W., Walter, Henrik, Hoekstra, Pieter J., Nyquist, Paul A., Franke, Barbara, Bennett, David A., Grabe, Hans J., Johnson, Andrew D., Chen, Christopher, van Duijn, Cornelia M., Lopez, Oscar L., Fornage, Myriam, Wardlaw, Joanna M., Schmidt, Reinhold, DeCarli, Charles, De Jager, Philip L., Villringer, Arno, Debette, Stephanie, Gudnason, Vilmundur, Medland, Sarah E., Shulman, Joshua M., Thompson, Paul M., Seshadri, Sudha, and Ikram, M. Arfan

Abstract

Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.

Published
2019
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39. Senate disruption ends quickly after ricin found in Frist's office

Author

Stevens, Allison

Subjects
Legislators -- Political activity, Government
Abstract

Just over two years after the anthrax attack, the discovery of ricin in the personal office of Majority Leader Bill Frist on February 2, 2004 was far less disruptive thanks to technological advances, new protocol and an expanded Capitol police force. Law enforcement officers roped off the area, aided by the FBI and other federal agencies, monitored the aides for symptoms of ricin and experts feel that the form of ricin found in Frist's Dirksen office was not dangerous or as easily spread as the anthrax

Published
2004

42. Lieberman keeps moderation as his Democratic byword

Author

Stevens, Allison

Subjects
Legislators -- Management, Legislators -- Public relations, Political campaigns -- Evaluation, Electioneering -- Evaluation, Company business management, Company public relations, Government
Abstract

Senator Joseph I. Lieberman of Connecticut has shunned conventional ideological roles and hopes to take the middle ground all the way to the White House after adopting a version of Bill Clinton's 'New Democratic' presidential campaign. Lieberman's quiet and contemplative public persona have contributed as much to his reputation as a centrist as his record, which was very much in evidence during the contested 2000 presidential election.

Published
2003

44. 7 Tesla MRI of the ex vivo human brain at 100 micron resolution

Author

Edlow, Brian L., primary, Mareyam, Azma, additional, Horn, Andreas, additional, Polimeni, Jonathan R., additional, Witzel, Thomas, additional, Tisdall, M. Dylan, additional, Augustinack, Jean, additional, Stockmann, Jason P., additional, Diamond, Bram R., additional, Stevens, Allison, additional, Tirrell, Lee S., additional, Folkerth, Rebecca D., additional, Wald, Lawrence L., additional, Fischl, Bruce, additional, and van der Kouwe, Andre, additional

Published
2019
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47. Multimodal Characterization of the Late Effects of Traumatic Brain Injury: A Methodological Overview of the Late Effects of Traumatic Brain Injury Project

Author

Edlow, Brian L., primary, Keene, C. Dirk, additional, Perl, Daniel P., additional, Iacono, Diego, additional, Folkerth, Rebecca D., additional, Stewart, William, additional, Mac Donald, Christine L., additional, Augustinack, Jean, additional, Diaz-Arrastia, Ramon, additional, Estrada, Camilo, additional, Flannery, Elissa, additional, Gordon, Wayne A., additional, Grabowski, Thomas J., additional, Hansen, Kelly, additional, Hoffman, Jeanne, additional, Kroenke, Christopher, additional, Larson, Eric B., additional, Lee, Patricia, additional, Mareyam, Azma, additional, McNab, Jennifer A., additional, McPhee, Jeanne, additional, Moreau, Allison L., additional, Renz, Anne, additional, Richmire, KatieRose, additional, Stevens, Allison, additional, Tang, Cheuk Y., additional, Tirrell, Lee S., additional, Trittschuh, Emily H., additional, van der Kouwe, Andre, additional, Varjabedian, Ani, additional, Wald, Lawrence L., additional, Wu, Ona, additional, Yendiki, Anastasia, additional, Young, Liza, additional, Zöllei, Lilla, additional, Fischl, Bruce, additional, Crane, Paul K., additional, and Dams-O'Connor, Kristen, additional

Published
2018
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48. Sinking Santorum: why are gays and lesbians pounding the pavement for a U.S. Senate candidate who opposes same-sex marriage and won't stand up for gays in the military? Look at whom he has a good chance of defeating

Author

Stevens, Allison

Subjects
United States. Senate -- Political aspects -- Political activity -- Services, Same-sex marriage -- Social aspects -- Political aspects, News, opinion and commentary
Abstract

For lesbian and gay political activists, asking for votes in Bella Vista--a progressive urban community on the edge of south Philadelphia just a stone's throw from the city's main gay [...]

Published
2006

49. 'Can't do' label shadows Frist as legislative season wanes

Author

Stevens, Allison

Subjects
Presidents -- Elections, Agenda-setting (Political science), Government
Abstract

The Senate Majority Leader Bill Frist has four weeks before the target October 1, 2004, adjournment date to pass the rest of the GOP agenda, or come back for an official session, with intelligence overhaul, appropriations and tax cuts at the top of the list. However, if Frist fails to achieve a quick, bipartisan consensus on the matter, the party might pay a heavy price in the election, a result that might hurt Frist if he plans to make a bid for his party's presidential nomination in 2008.

Published
2004

50. Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy

Author

Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Fischl, Bruce, Yendiki, Anastasia, Panneck, Patricia, Srinivasan, Priti, Stevens, Allison, Zollei, Lilla, Augustinack, Jean, Wang, Ruopeng, Salat, David, Ehrlich, Stefan, Behrens, Tim, Jbabdi, Saad, Gollub, Randy, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Fischl, Bruce, Yendiki, Anastasia, Panneck, Patricia, Srinivasan, Priti, Stevens, Allison, Zollei, Lilla, Augustinack, Jean, Wang, Ruopeng, Salat, David, Ehrlich, Stefan, Behrens, Tim, Jbabdi, Saad, and Gollub, Randy

Abstract

We have developed a method for automated probabilistic reconstruction of a set of major white-matter pathways from diffusion-weighted MR images. Our method is called TRACULA (TRActs Constrained by UnderLying Anatomy) and utilizes prior information on the anatomy of the pathways from a set of training subjects. By incorporating this prior knowledge in the reconstruction procedure, our method obviates the need for manual interaction with the tract solutions at a later stage and thus facilitates the application of tractography to large studies. In this paper we illustrate the application of the method on data from a schizophrenia study and investigate whether the inclusion of both patients and healthy subjects in the training set affects our ability to reconstruct the pathways reliably. We show that, since our method does not constrain the exact spatial location or shape of the pathways but only their trajectory relative to the surrounding anatomical structures, a set a of healthy training subjects can be used to reconstruct the pathways accurately in patients as well as in controls., National Institute for Biomedical Imaging and Bioengineering (U.S.) (Pathway to Independence Award EB008129), National Institutes of Health (U.S.). Blueprint for Neuroscience Research (U01-MH093765), National Center for Research Resources (U.S.) (P41-RR14075 and U24-RR021382), National Institute for Biomedical Imaging and Bioengineering (U.S.) (R01-EB006758), National Institute on Aging (R01-AG022381), National Center for Complementary and Alternative Medicine (U.S.) (RC1-AT005728), National Institute of Neurological Disorders and Stroke (U.S.) (R01-NS052585, R21-NS072652, and R01-NS070963), Ellison Medical Foundation. Autism & Dyslexia Project

Published
2017

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