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This essay examines the literary career of Anglo-Irish peer Lewis Strange Wingfield (1842-1891) in relation to the rise of investigative journalism and Victorian debates over the treatment of mental illness. Situating his work in the context of the first covert investigations into asylums in Britain and the United States, it focuses on Wingfield's use of disguise to infiltrate a private London asylum for the purpose of researching his novel Gehenna; or, Havens of Unrest (1882). Wingfield's pioneering experiment in undercover authorship, we argue, sheds new light on investigative journalism's impact on both the form and thematics of the nineteenth-century realist novel.

Conventionally understood as an act of mastery by one (state) actor over a less powerful other, colonialism is defined primarily by its effects. These include, usually in combination, military conq...

This essay presents the discovery of the American serialization of Joseph Conrad’s Lord Jim in New York’s Evening Telegram in 1903. This ‘lost’ serialization, it argues, invites a new perspective on Conrad’s early career by foregrounding the role of newspaper serialization and syndication in establishing his literary standing. After surveying the principal differences in the respective reading experiences of the periodical versus the book, it concludes by proposing that the prominence of women among Conrad’s first audiences requires us to reassess the basis for his success in North America and elsewhere. &nbsp

There is something faintly tautologous about the pairing “Transnational Conrad”. The future Joseph Conrad (1857–1924) was born in Berdyczow, at that time a part of Poland annexed by Russia, now in ...

Conrad and the Harmsworth Empire The Daily Mail, London Magazine, Times, Evening News, and Hutchinson's Magazine

The libraries of universities and other research institutions are home to an abundance of academic journals, published in multifarious sizes, thicknesses, languages, and formats, with covers varying from black to psychedelic and covering every subject imaginable. More uniformity of format would favour the author, who would no longer have to tailor style to wherever the latest contribution is being submitted, but the current diversity of formats is aimed at the reader. Long may it so remain.

There is a noticeable lack of targeted treatment options for marijuana dependence, in particular pharmacologic approaches. This is the first study evaluating a targeted pharmacologic approach for marijuana dependence. The goals of the study were to determine if such patients would seek pharmacologic treatment, whether these patients could be retained in treatment using a design previously developed for cocaine-dependent patients, and especially whether divalproex sodium showed promise as a treatment agent for marijuana dependence. We found that marijuana-dependent patients will seek treatment, and such patients can be adequately maintained in a pharmacologic trial. Regardless of treatment group, patients reported a significant reduction in their frequency and amount of marijuana use as well as a reduction in irritability. Given the lack of proven effective treatments for marijuana dependence, pharmacotherapies should be sought. The design of a preliminary clinical trial should include a psychosocial/behavioral intervention emphasizing motivation and medication compliance and a placebo control group.

The following essay offers a close reading of an obscure imperial short story, Gertrude Page’s ‘A Terror That Saved’ (1912), in order to question the assumptions that short fiction about imperial adventure is necessarily masculine, and that short stories with empire settings are primarily vehicles for colonial ideology. When the story in question was written, its author had recently moved from Britain to Rhodesia, a colony whose owner-administrator, the British South Africa Company (BSAC), had strong financial and political incentives for promoting itself to settlers, investors, and the reading public in Britain. Even so, I argue, it would be a mistake to view this tale as being ‘about’ empire in any simple sense, to infer that its huge audience was actively endorsing imperialism, or to equate its generic conventionality and moral conservatism with a static, traditional, and collective worldview. Instead, I draw on Richard Ohmann’s landmark analysis of magazine short stories to sketch an alternative framework within which to understand the popularity of such short stories and to reconstruct the ways in which they were likely read, in particular by women.

Upon light irradiation, Fluorophore-cell-penetrating peptide (Fl-CPP) conjugates can disrupt the integrity of biological membranes. This activity can in turn be used to photoinduce the disruption of endocytic organelles and promote the delivery of entrapped macromolecules such as proteins or RNAs into live cells. Recent mechanistic studies have shown that ROS production by the fluorophore and a latent lytic ability of CPPs act in synergy to elicit photolysis. However, how the structure of fluorophore-CPP conjugates impacts this synergistic activity remains unclear. Herein, using red blood cells (RBCs) as a model of biological membranes, we show that the number of arginine residues in a CPP as well as the position of fluorophore with respect to the CPP dramatically affect the photolytic activity of a fluorophore-CPP conjugate. These factors should therefore be considered for the development of effective photoinducible delivery agents.