1. An altered uterine microbiota with endometrial hyperplasia.
- Author
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Ying X, Xu G, Wang H, and Wang Y
- Subjects
- Female, Humans, Middle Aged, Adult, RNA, Ribosomal, 16S genetics, Serratia isolation & purification, Serratia genetics, Serratia pathogenicity, Stenotrophomonas isolation & purification, Stenotrophomonas genetics, Microbiota, Endometrial Hyperplasia microbiology, Endometrial Hyperplasia pathology, Uterus microbiology, Uterus pathology, Bacteria classification, Bacteria isolation & purification, Bacteria genetics
- Abstract
Background: Endometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear., Results: The present study investigated the uterine microbiome in patients with benign uterine conditions and endometrial hyperplasia. A significant structural shift in the uterine microbiome of patients with endometrial hyperplasia compared to those with benign conditions was found. Delftia, Serratia and Stenotrophomonas were significantly enriched in endometrial hyperplasia samples and associated with the presence of endometrial hyperplasia., Conclusions: The novel finding suggested that increased abundance of Delftia, Serratia and Stenotrophomonas is associated with the presence of endometrial hyperplasia. Further investigation is needed to determine the value of these microbes as biomarkers for endometrial hyperplasia., (© 2024. The Author(s).)
- Published
- 2024
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