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Diversity of bla L1-like genes in Stenotrophomonas species: insights from genome analysis of publicly available genome sequences.

Authors :
Yamada K
Ishii Y
Tateda K
Source :
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Sep 19; Vol. 67 (9), pp. e0067323. Date of Electronic Publication: 2023 Aug 16.
Publication Year :
2023

Abstract

L1 metallo-β-lactamases produced by Stenotrophomonas maltophilia exhibit high diversity. Here, we characterized the genomes of Stenotrophomonas species harboring bla <subscript>L1-like</subscript> genes using publicly available genome sequences. Our findings provide evidence that Stenotrophomonas species with bla <subscript>L1-like</subscript> genes constitute a complex comprising many species with high genetic diversity, and similarities between bla <subscript>L1-like</subscript> genes are lower than those of the genome. This suggests that the diversity of bla <subscript>L1-like</subscript> is attributable to species diversity in Stenotrophomonas species harboring bla <subscript>L1-like</subscript> and the rapid evolutionary changes in bla <subscript>L1-like</subscript> genes.<br />Competing Interests: The authors declare no conflict of interest.

Details

Language :
English
ISSN :
1098-6596
Volume :
67
Issue :
9
Database :
MEDLINE
Journal :
Antimicrobial agents and chemotherapy
Publication Type :
Academic Journal
Accession number :
37584548
Full Text :
https://doi.org/10.1128/aac.00673-23