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Your search keyword '"Stella Rwezaura"' showing total 2 results
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2 results on '"Stella Rwezaura"'

1. Diagnostic delay in ankle and foot tuberculosis resulting in tuberculoma and tuberculous meningitis in a middle-aged female: A case report

Author

Hedwiga F Swai, Sibtain M Moledina, Sylvia B Nsato, Amina Mgunya, Joan Rugemalila, Veridiana Byemelwa, Sharon Ismail, Pauline Chale, Luth Mwapule, Alex Masao, Jude Tarimo, Amunga Meda, Fatuma Muhali, May Shoo, Eva Uiso, Stella Rwezaura, Eliaichi Minja, Deogratius Beda, Sarah K Nyagabona, Onesmo Kisanga, Sayan Salehe, Faraja Chiwanga, Said Mwemba, John Rwegasha, and Grace Shayo

Subjects
Medicine (General), R5-920
Abstract

A middle-aged woman presents with chronic foot arthritis which progressed to a non-healing ulcer, which was unresponsive to conventional antibiotics and debridement. She then developed cerebral manifestations and was empirically treated with antitubercular medications which led to healing of the ulcer. Unfortunately, delays in initiating treatment resulted in development of other extrapulmonary tuberculosis complications such as cerebral tuberculoma with tuberculous meningitis. She was subsequently diagnosed with neurocysticercosis which continued to worsen during her hospital stay. She eventually succumbed to her illness due to the complications and a possible nosocomial infection. This case highlights the challenges with diagnosis of uncommon presentations of common diseases in an endemic area, leading to diagnostic delays and development of serious complications.

Published
2024
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2. Clinical epidemiology of individuals with Sickle cell anemia using Hydroxyurea at Muhimbili National Hospital, Dar Es Salaam, Tanzania

Author

Raphael Z. Sangeda, Bruno Mmbando, Edward Kija, Furahini Tluway, Elisha Osati, Abel Makubi, Evarist Msaki, Julie Makani, Siana Nkya, Harvest Mariki, Florence Urio, Musa Makongoro, Deogratias Soka, Magdalena Lyimo, Christina Kindole, Josephine Mgaya, and Stella Rwezaura

Subjects
medicine.medical_specialty, Anemia, business.industry, Disease, medicine.disease, Sickle cell anemia, Pathophysiology, Acute chest syndrome, Clinical trial, hemic and lymphatic diseases, Internal medicine, Fetal hemoglobin, medicine, business, Stroke
Abstract

Background: The pathophysiology of sickle cell disease (SCD) is complex and involves nitric oxide depletion, increased inflammation/adhesion molecules and vaso-occlusion in addition to the chronic hemolytic anemia. This pathophysiology results in systemic clinical complications including recurrent episodes of severe pain, stroke, acute chest syndrome (ACS) and an increased susceptibility to infection. SCD severity varies among individuals and fetal hemoglobin (HbF) is known as a major modulator of the disease. To date, hydroxyurea (HU) is a known intervention that acts by increasing HbF in individuals with SCD. The increase in HbF reduces the risk of ‘sickling’ events and improves clinical outcomes. This is the first study on the use of HU in individuals with SCA in Tanzania.Methods: A case-control study to determine the proportion, indications, clinical and laboratory outcomes of SCD patients with HU use was conducted at Muhimbili National Hospital in Dar Es Salaam, Tanzania.Results: Forty-two patients with Sickle cell anemia (SCA) on HU treatment and 32 patients with SCA not on HU treatment were enrolled. The proportion of HU use by individuals with SCA at Muhimbili National Hospital was 10 per 1000. The mean HbF % was 9.8 ± 2.4 vs 6.2 ±1.4 for controls (P

Published
2020
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