602 results on '"Steiropoulos, P."'
Search Results
2. Extrafine single inhaler triple therapy effectiveness in COPD patients previously treated with multiple-inhaler triple therapy: the TRIWIN study
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Paschalis Steiropoulos, Niki Georgatou, George Krommidas, Konstantinos Bartziokas, Aliki Korkontzelou, Panos Katerelos, Petros Efstathopoulos, Dimosthenis Papapetrou, Stavros Theodorakis, and Konstantinos Porpodis
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Diseases of the respiratory system ,RC705-779 - Abstract
Background: The extrafine single inhaler triple therapy (efSITT) containing beclomethasone dipropionate/formoterol fumarate/glycopyrronium 87/5/9 μg has proved to be efficacious in patients with chronic obstructive pulmonary disease (COPD) in randomized control trials. Objective: TRIWIN study evaluated the effectiveness of efSITT delivering beclomethasone dipropionate/formoterol fumarate/glycopyrronium 87/5/9 μg in COPD patients previously treated with multiple-inhaler triple therapy (MITT) in a real-world study in Greece. Design: Prospective, multicenter, observational, non-interventional study was conducted over 24 weeks. Methods: A total of 475 eligible patients had moderate-to-severe COPD, an indication for treatment with efSITT, and were symptomatic despite receiving MITT. COPD Assessment Test (CAT) score, pulmonary function parameters, use of rescue medication, and adherence to inhaler use were recorded at baseline (Visit 1), 3 (Visit 2), and 6 months (Visit 3) after treatment. Results: Mean CAT score decreased from 21.4 points at Visit 1, to 16.6 at Visit 2 and 15.1 at Visit 3 ( p
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- 2024
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3. Treatment Adherence and Health Status of Patients With COPD Under Treatment With Salmeterol/Fluticasone via the Elpenhaler® Device: The AHEAD Study
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Konstantinos P. Exarchos, Georgios Hillas, Paschalis Steiropoulos, Polyanthi Papanastasiou, Athena Gogali, and Konstantinos Kostikas
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adherence ,chronic obstructive pulmonary disease ,COPD ,Diseases of the respiratory system ,RC705-779 - Abstract
ABSTRACT Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous progressive lung condition characterized by long‐term respiratory symptoms and airflow limitation. Appropriate bronchodilation is the cornerstone of COPD treatment, leading to better health status as well as benefits in prognosis and mortality. Methods In the current open, noninterventional, observational study, 716 patients diagnosed with COPD of variable severity were administered a fixed‐dose combination (FDC) of fluticasone propionate and salmeterol (500 + 50 mcg) through the Elpenhaler® device. The patients' adherence to treatment (based on the MMAS‐8 [8‐item Morisky Medication Adherence Scale]) and health status (based on the CCQ [Clinical COPD Questionnaire]) were assessed at the beginning of the study and at the end of the 3‐month follow‐up period. Results The mean ± SD MMAS‐8 score at 1 and 3 months was 6.12 ± 1.89 and 6.45 ± 1.80, respectively, indicating medium adherence overall; however, there was a statistically significant increase of 0.33 units in the MMAS‐8 score at the end of the follow‐up (paired t‐test p
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- 2024
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4. Editorial: Exploring the role of adaptive immunity in chronic airway respiratory diseases
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Evangelia Fouka, Apostolos Bossios, Paschalis Steiropoulos, and Konstantinos Samitas
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adaptive immunity ,t-regulatory (Treg) cells ,asthma ,COPD—chronic obstructive pulmonary disease ,ILC2—group-2 innate lymphoid cell ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2024
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5. Pulmonary Function Tests Post-Stroke. Correlation between Lung Function, Severity of Stroke, and Improvement after Respiratory Muscle Training
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Fotios Drakopanagiotakis, Konstantinos Bonelis, Paschalis Steiropoulos, Dimitrios Tsiptsios, Anastasia Sousanidou, Foteini Christidi, Aimilios Gkantzios, Aspasia Serdari, Styliani Voutidou, Chrysoula-Maria Takou, Christos Kokkotis, Nikolaos Aggelousis, and Konstantinos Vadikolias
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pulmonary function tests ,MIP ,MEP ,stroke ,respiratory muscle training ,Medicine ,Internal medicine ,RC31-1245 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Stroke is a significant cause of mortality and chronic morbidity caused by cardiovascular disease. Respiratory muscles can be affected in stroke survivors, leading to stroke complications, such as respiratory infections. Respiratory function can be assessed using pulmonary function tests (PFTs). Data regarding PFTs in stroke survivors are limited. We reviewed the correlation between PFTs and stroke severity or degree of disability. Furthermore, we reviewed the PFT change in stroke patients undergoing a respiratory muscle training program. We searched PubMed until September 2023 using inclusion and exclusion criteria in order to identify studies reporting PFTs post-stroke and their change after a respiratory muscle training program. Outcomes included lung function parameters (FEV1, FVC, PEF, MIP and MEP) were measured in acute or chronic stroke survivors. We identified 22 studies of stroke patients, who had undergone PFTs and 24 randomised controlled trials in stroke patients having PFTs after respiratory muscle training. The number of patients included was limited and studies were characterised by great heterogeneity regarding the studied population and the applied intervention. In general, PFTs were significantly reduced compared to healthy controls and predicted normal values and associated with stroke severity. Furthermore, we found that respiratory muscle training was associated with significant improvement in various PFT parameters and functional stroke parameters. PFTs are associated with stroke severity and are improved after respiratory muscle training.
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- 2024
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6. The Relationships of Specific Cognitive Control Abilities with Objective and Subjective Sleep Parameters in Mild Cognitive Impairment: Revealing the Association between Cognitive Planning and Sleep Duration
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Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, and Magda Tsolaki
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cognitive abilities ,executive functions ,mild cognitive impairment ,sleep ,sleep disturbances ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
This study aimed to examine the associations between specific sleep parameters and specific aspects of cognitive functioning in individuals diagnosed with mild cognitive impairment (MCI), compared with healthy controls (HCs) by using cognitive, subjective, and objective sleep measures. A total of 179 participants were enrolled, all aged ≥ 65 years (mean age = 70.23; SD = 4.74) and with a minimum of six years of education (mean = 12.35; SD = 3.22). The sample included 46 HCs (36 females), 75 individuals with amnestic MCI (aMCI) (51 females), and 58 individuals with non-amnestic MCI (naMCI) (39 females). Inhibition, cognitive flexibility as a combined application of inhibitory control and set shifting or task/rule switching, and planning were examined. The following D-KEFS subtests were administered for their evaluation: Verbal Fluency Test, Color–Word Interference Test, and Tower Test. Self-reported sleep questionnaires (Athens Insomnia Scale, Stop-Bang questionnaire, and Pittsburg Sleep Quality Index) were used for subjective sleep assessments. Actigraphy was used for objective sleep measurements. Mixed-measures ANOVA, MANOVA, and one-way ANOVA, as well as the Scheffe post hoc test, were applied to the data. The results showed that the three groups exhibited statistically significant differences in the Tower Test (total achievement score, total number of administered problems, and total rule violations). As regards objective sleep measurements, the total sleep time (TST) was measured using actigraphy, and indicated that there are significant differences, with the HC group having a significantly higher mean TST compared to the naMCI group. The relationships evaluated in the TST Tower Test were found to be statistically significant. The findings are discussed in the context of potential parameters that can support the connection between sleep duration, measured as TST, and cognitive planning, as measured using the Tower Test.
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- 2024
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7. High-Flow Nasal Oxygen Therapy in Acute Hypoxemic Respiratory Failure: Concise Review on Technology and Initial Methodology.
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Guia, Miguel, Alpay, Nilgun, Gerardo, António, Madney, Yasmin, Abdelrahim, Mohamed, Saeed, Haitham, Harb, Hadeer, Gonçalves, Gil, Cabrita, Bruno, Alqahtani, Jaber, El-Khatib, Mohamad, Gómez-Ríos, Manuel, Fakharian, Atefeh, Ciobanu, Laura, Karim, Habib, Piervincenzi, Edoardo, Scharffenberg, Martin, Steiropoulos, Paschalis, LeMaster, William, Barjaktarevic, Igor, Wittenstein, Jakob, Diaz-Abad, Montserrat, Perren, Andreas, Nicolini, Antonello, Spadaro, Savino, Garuti, Giancarlo, Petroianni, Angelo, and Esquinas, Antonio
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High-flow nasal cannula oxygen therapy (HFNCOT) system consists of an air/oxygen supply system capable of delivering up to 100% humidified and heated oxygen at a flow rate of up to 80 L/min. The system includes a blender, active humidifier, single heated tube, and nasal cannula. HFNCOT has many physiological advantages compared with other standard oxygen therapies, such as anatomical dead space washout, more constant fraction of inspired oxygen, positive end-expiratory (PEEP) effect, supplement of adequate humidification and maintenance of muco-ciliary function. HFNCOT is mostly used for hypoxemic acute respiratory failure, although it also has other indications. HFNCOT is a common choice of physicians as its technology makes it more silent and comfortable. Though HFNCOT is used in many clinical settings, there is a lack of publications addressing devices and initial settings. We present a review on HFNCOT, with focus on device and application methodology.
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- 2021
8. Effect of Third Molar Surgery on Sleep Health Parameters of Young Adults: An Observational Study
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Ioulianos Apessos, Theodoros Lillis, Athanasios Voulgaris, Kostas Archontogeorgis, Paschalis Steiropoulos, and Nikolaos Dabarakis
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third molar surgery ,oral surgery ,surgical extraction ,sleep quality ,daytime sleepiness ,insomnia severity ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: The role of surgical extraction of the third molar in patients’ sleep quality remains unclear, although it is one of the most common oral surgical procedures. The aim of this study is to assess the changes in patient-reported sleep health outcomes after third molar surgery and to investigate any associations between sleep parameters and post-extraction pain. Materials and Methods: Young adults without known comorbidities who were in need of mandibular third molar surgical extraction were included. All participants completed a sleep diary, the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI) and Athens Insomnia Scale (AIS) questionnaires, which were used to assess sleep habits, daytime sleepiness, sleep quality and insomnia severity one week before and after extraction. In addition, a visual analog scale was completed postoperatively to assess the perception of pain. Results: Out of 75 patients who completed the study protocol, 32 (42.7%) were males and 43 (57.3%) were females, with a mean age of 24.01 (±3.43) years. Postoperatively, statistically significant higher scores were observed for PSQI [4.85 (±2.32) before vs. 5.39 (±2.75) after, p = 0.041], AIS [5.56 (±3.23) before vs. 6.91 (±4.06) after, p < 0.001] and average weekly number of nocturnal awakenings [2.01 (±3.72) before vs. 4.19 (±5.20) after, p < 0.001] but not for ESS, average weekly sleep duration and average weekly sleep onset latency. Pain perception was increased in patients who slept worse on almost all seven postoperative days, although this did not reach statistical significance. Conclusions: Third molar surgery impacts sleep quality and insomnia severity in the first week after extraction, while there is no effect on daytime sleepiness. The worsening of subjective sleep symptoms after extraction may be associated with an increased perception of pain.
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- 2024
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9. Pathogenesis of Pulmonary Manifestations in ANCA-Associated Vasculitis and Goodpasture Syndrome
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Evangelia Fouka, Fotios Drakopanagiotakis, and Paschalis Steiropoulos
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pathogenesis ,ANCA-associated vasculitis ,lung ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Pulmonary manifestations of vasculitis are associated with significant morbidity and mortality in affected individuals. They result from a complex interplay between immune dysregulation, which leads to vascular inflammation and tissue damage. This review explored the underlying pathogenesis of pulmonary involvement in vasculitis, encompassing various forms such as granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and anti-GBM disease. Mechanisms involving ANCA and anti-GBM autoantibodies, neutrophil activation, and neutrophil extracellular trap (NETs) formation are discussed, along with the role of the complement system in inducing pulmonary injury. Furthermore, the impact of genetic predisposition and environmental factors on disease susceptibility and severity was considered, and the current treatment options were presented. Understanding the mechanisms involved in the pathogenesis of pulmonary vasculitis is crucial for developing targeted therapies and improving clinical outcomes in affected individuals.
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- 2024
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10. Effect of the Implementation of a Structured Diet Management Plan on the Severity of Obstructive Sleep Apnea: A Systematic Review
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Rokou, Aikaterini, Eleftheriou, Anna, Tsigalou, Christina, Apessos, Ioulianos, Nena, Evangelia, Dalamaga, Maria, Voulgaris, Athanasios, and Steiropoulos, Paschalis
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- 2023
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11. Editorial: Road trip from mild to severe asthmatic inflammation: the traffic lights of biomarkers in asthma management
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Konstantinos Porpodis, Ioanna Tsiouprou, Paschalis Steiropoulos, Spyridon Gougousis, Harissios Vliagoftis, and Kalliopi Domvri
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asthma ,biomarkers ,biologics ,personalized treatment approaches ,airway remodeling ,Medicine (General) ,R5-920 - Published
- 2023
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12. Effect of compliance to continuous positive airway pressure on exacerbations, lung function and symptoms in patients with chronic obstructive pulmonary disease and obstructive sleep apnea (overlap syndrome)
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Athanasios Voulgaris, Kostas Archontogeorgis, Stavros Anevlavis, Michail Fanaridis, Marios E. Froudarakis, Sofia Schiza, and Paschalis Steiropoulos
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chronic obstructive pulmonary disease ,compliance ,continuous positive airway pressure ,exacerbations ,obstructive sleep apnea ,overlap syndrome ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Introduction Patients with overlap syndrome (OS), that is obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD), are at increased risk of acute exacerbations related to COPD (AECOPD). We assessed the effect of CPAP compliance on AECOPD, symptoms and pulmonary function in OS patients. Methods Consecutive OS patients underwent assessment at baseline and at 12 months under treatment with CPAP of: AECOPD and hospitalizations, COPD Assessment Test (CAT) and modified British Medical Research Council (mMRC) questionnaires, pulmonary function testing and 6‐min walking test (6MWT). Results In total, 59 patients (54 males) with OS were followed for 12 months and divided post hoc according to CPAP compliance into: group A with good (≥4 h CPAP use/night, n = 29) and group B with poor (
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- 2023
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13. Immunotherapy and Chemotherapy Versus Sleep Disturbances for NSCLC Patients
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Paul Zarogoulidis, Dimitrios Petridis, Christoforos Kosmidis, Konstantinos Sapalidis, Lila Nena, Dimitrios Matthaios, Konstantinos Porpodis, Paschalis Kakavelas, and Paschalis Steiropoulos
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lung cancer ,cancer ,chemotherapy ,sleep disturbances ,fatigue ,insomnia ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Introduction: Cancer patients are known to experience sleep disturbances that differ between disease stages and treatments. Regarding lung cancer patients and immunotherapy, information on their sleep disturbances has been recently acquired, but no comparison has been made between different treatment modalities. Patients and Methods: We recruited 98 non-small cell lung cancer patients; 49 had programmed death-ligand 1 expression of ≥50% and received immunotherapy as first-line treatment and 49 had programmed death-ligand 1 expression in the range from 0–49 and received chemotherapy as first-line treatment. All patients were stage IV, but with no bone metastasis. Sleep disturbances were recorded through polysomnography and sleep questionnaires. Results: For immunotherapy patients with PD-L1 expression ≥ 50%, the disease response was rapid and the sleep disturbances decreased rapidly. On the other hand, for chemotherapy patients, the sleep disturbances remained for all those patients that had partial response and stable disease. It was noticed that chemotherapy drugs induce severe adverse effects. Discussion: In our study, it was observed that patients with complete response had reduced sleep disturbances in the case of immunotherapy patients. However, sleep disturbances continued for several patients in the chemotherapy group due to the adverse effects of chemotherapy drugs. In conclusion: Immunotherapy drugs on their own do not induce sleep disturbances and, through treatment response, alleviate sleep disturbances in lung cancer patients.
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- 2023
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14. Sleep and cardiometabolic comorbidities in the obstructive sleep apnoea–COPD overlap syndrome: data from the European Sleep Apnoea Database
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Mafalda van Zeller, Ozen K. Basoglu, Johan Verbraecken, Carolina Lombardi, Walter T. McNicholas, Jean-Louis Pepin, Paschalis Steiropoulos, Pawel Sliwinski, Daniela Correia, Maria R. Bonsignore, Sophia E. Schiza, Jan Hedner, Ludger Grote, Marta Drummond, the European Sleep Apnoea Database study group, and P. Steiropoulos
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Medicine - Abstract
Aim The impact of obstructive sleep apnoea (OSA)–COPD overlap syndrome (OVS) on sleep quality and cardiovascular outcomes has not been fully explored. We aimed to compare clinical and polysomnographic characteristics of patients with OVS versus patients with OSA, and to explore pathophysiological links between OVS and comorbidities. Study design and methods This cross-sectional analysis initially included data from 5600 patients with OSA and lung function in the European Sleep Apnoea Database. Two subgroups of patients with OSA (n=1018) or OVS (n=509) were matched (2:1) based on sex, age, body mass index and apnoea–hypopnea index at baseline. Results After matching, patients with OVS had more severe hypoxia, lower sleep efficiency and presented with higher prevalences of arterial hypertension, ischaemic heart disease and heart failure compared with patients with OSA. OVS was associated with a significant decrease in sleep efficiency (mean difference (β) −3.0%, 95% CI −4.7 to −1.3) and in nocturnal mean peripheral oxyhaemoglobin saturation (SpO2) (β −1.1%, 95% CI −1.5 to −0.7). Further analysis revealed that a decrease in forced expiratory volume in 1 s and arterial oxygen tension was related to a decrease in sleep efficiency and in mean nocturnal SpO2. A COPD diagnosis increased the odds of having heart failure by 1.75 (95% CI 1.15–2.67) and systemic hypertension by 1.36 (95% CI 1.07–1.73). Nocturnal hypoxia was strongly associated with comorbidities; the mean nocturnal SpO2 and T90 (increase in time below SpO2 of 90%) were associated with increased odds of systemic hypertension, diabetes and heart failure but the oxygen desaturation index was only related to hypertension and diabetes. Conclusion Patients with OVS presented with more sleep-related hypoxia, a reduced sleep quality and a higher risk for heart failure and hypertension.
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- 2023
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15. Prevalence and Characteristics of Patients with Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: Overlap Syndrome
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Michail Fanaridis, Izolde Bouloukaki, Georgios Stathakis, Paschalis Steiropoulos, Nikos Tzanakis, Violeta Moniaki, Eleni Mavroudi, Ioanna Tsiligianni, and Sophia Schiza
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obstructive sleep apnea ,chronic obstructive pulmonary disease ,overlap syndrome ,polysomnography ,sleep architecture ,cardiovascular disease ,Science - Abstract
Overlap syndrome (OVS) is a distinct clinical entity that seems to result in potential cardiovascular consequences. We aimed to estimate the prevalence and risk factors for OVS in OSA patients and analyze clinical and PSG characteristics associated with OVS. In this cross-sectional study, 2616 patients evaluated for OSA underwent type-1 polysomnography (PSG). They were grouped as pure OSA (AHI > 15/h) and OVS patients. Demographics, PSG data, pulmonary function tests and arterial blood gases (ABGs) were compared between groups after adjustments for confounders. OSA was diagnosed in 2108 out of 2616 patients. Of those, 398 (19%) had OVS. Independent predictors of OVS were older age [OR: 5.386 (4.153–6.987)], current/former smoking [OR: 11.577 (7.232–18.532)], BMI [OR: 2.901 (2.082–4.044)] and ABG measurements [PaCO2 ≥ 45 OR: 4.648 (3.078–7.019), PO2 [OR: 0.934 (0.920–0.949)], HCO3− [OR: 1.196 (1.133–1.263), all p < 0.001]. OVS was also associated with prevalent hypertension [OR: 1.345 (1.030–1.758), p = 0.03] and cardiovascular disease [OR: 1.617 (1.229–2.126), p < 0.001], depressive symptoms [OR: 1.741 (1.230–2.465), p = 0.002] and nocturia [OR: 1.944 (1.378–2.742), p < 0.001], as well as with indices of OSA severity. Disturbances in sleep architecture were more prominent in OVS expressed by lower %N3 and REM% and higher arousal index. Our data suggest that OVS is prevalent among OSA patients, with distinct clinical and PSG characteristics. These characteristics could be utilized as predictive factors for early identification and further evaluation of these patients towards desirable patient-reported outcomes.
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- 2024
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16. Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea
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Kostas Archontogeorgis, Nicholas-Tiberio Economou, Panagiotis Bargiotas, Evangelia Nena, Athanasios Voulgaris, Konstantina Chadia, Georgia Trakada, Andrea Romigi, and Paschalis Steiropoulos
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vitamin D ,sleepiness ,obstructive sleep apnea (OSA) ,sleep apnea ,Epworth sleepiness scale (ESS) ,Medicine - Abstract
Study Objectives: The aim of this cross-sectional study is to explore the association between serum 25-hydroxyvitamin D [25(OH)D] levels, a marker of Vitamin D status, and excessive daytime sleepiness (EDS), expressed as increased scores of the Epworth Sleepiness Scale (ESS), in a group of prospectively enrolled patients with obstructive sleep apnea (OSA). Methods: Newly diagnosed patients with OSA, divided into two groups, those with EDS (ESS > 10) and those without EDS (ESS < 10). All patients underwent night polysomnography. Measurement of serum 25(OH)D vitamin was performed using a radioimmunoassay. Results: In total, 217 patients with OSA (197 males and 20 females) were included. Patients with EDS had higher AHI (p < 0.001) values and lower mean serum 25(OH)D levels, compared with those of non-somnolent patients [17.4 (12.2–25.7) versus 21.1 (15.3–28.8) ng/mL, respectively, p = 0.005]. In patients with EDS, serum 25(OH)D levels correlated with average oxyhemoglobin saturation during sleep (r = 0.194, p = 0.043), and negatively with ESS score (r = −0.285, p = 0.003), AHΙ (r = −0.197, p = 0.040) and arousal index (r = −0.256, p = 0.019). Binary regression analysis identified Vit D serum levels (β = −0.045, OR: 0.956, 95% CI: 0.916–0.997, p = 0.035), total sleep time (β = 0.011, OR: 1.011, 95% CI: 1.002–1.021, p = 0.016) and AHI (β = 0.022, OR: 1.022, 95% CI: 1.003–1.043, p = 0.026) as independent predictors of EDS in patients with OSA. In patients with EDS, multiple regression analysis indicated that ESS score was negatively associated with Vit D serum levels (β = −0.135, p = 0.014) and minimum oxyhemoglobin saturation during sleep (β = −0.137, p = 0.043). Conclusions: In the present study, EDS in patients with OSA is associated with low levels of Vitamin D, while sleep hypoxia may play a role in this process.
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- 2024
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17. Unraveling the Link between Ιnsulin Resistance and Bronchial Asthma
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Konstantinos Bartziokas, Andriana I. Papaioannou, Fotios Drakopanagiotakis, Evanthia Gouveri, Nikolaos Papanas, and Paschalis Steiropoulos
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asthma ,insulin resistance ,antidiabetic drugs ,metabolic dysfunction ,obesity ,Biology (General) ,QH301-705.5 - Abstract
Evidence from large epidemiological studies has shown that obesity may predispose to increased Th2 inflammation and increase the odds of developing asthma. On the other hand, there is growing evidence suggesting that metabolic dysregulation that occurs with obesity, and more specifically hyperglycemia and insulin resistance, may modify immune cell function and in some degree systemic inflammation. Insulin resistance seldom occurs on its own, and in most cases constitutes a clinical component of metabolic syndrome, along with central obesity and dyslipidemia. Despite that, in some cases, hyperinsulinemia associated with insulin resistance has proven to be a stronger risk factor than body mass in developing asthma. This finding has been supported by recent experimental studies showing that insulin resistance may contribute to airway remodeling, promotion of airway smooth muscle (ASM) contractility and proliferation, increase of airway hyper-responsiveness and release of pro-inflammatory mediators from adipose tissue. All these effects indicate the potential impact of hyperinsulinemia on airway structure and function, suggesting the presence of a specific asthma phenotype with insulin resistance. Epidemiologic studies have found that individuals with severe and uncontrolled asthma have a higher prevalence of glycemic dysfunction, whereas longitudinal studies have linked glycemic dysfunction to an increased risk of asthma exacerbations. Since the components of metabolic syndrome interact with one another so much, it is challenging to identify each one’s specific role in asthma. This is why, over the last decade, additional studies have been conducted to determine whether treatment of type 2 diabetes mellitus affects comorbid asthma as shown by the incidence of asthma, asthma control and asthma-related exacerbations. The purpose of this review is to present the mechanism of action, and existing preclinical and clinical data, regarding the effect of insulin resistance in asthma.
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- 2024
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18. Exploring the association between sleep insufficiency and self-reported cardiovascular disease among northeastern Greeks
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Petros N. Fountoulakis, Aikaterini Terzoudi, Dimitrios Tsiptsios, Andreas S. Triantafyllis, Anestis Matziridis, Eleni Leontidou, Apostolos Manolis, Konstantinos Tsamakis, Andreas Ouranidis, Paschalis Steiropoulos, Theofanis Vorvolakos, Aspasia Serdari, and Gregory Tripsianis
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sleep insufficiency ,stroke ,cardiovascular disease ,angina. ,Psychology ,BF1-990 ,Consciousness. Cognition ,BF309-499 - Abstract
Objective: To explore the association of sleep characteristics with cardiovascular disease (CVD) using self-reported questionnaires. Material and Methods: 957 adults between 19 and 86 years old were enrolled in this cross-sectional study. The participants were classified into three groups [short (8h) sleepers] by using multistage stratified cluster sampling. CVD was defined by a positive response to the questions: “Have you been told by a doctor that you have had a heart attack or angina or stroke or have you undergone bypass surgery?”. Sleep quality, utilizing Epworth sleepiness scale, Athens insomnia scale, Pittsburgh sleep quality index and Berlin questionnaire, was also examined. Results: Prevalence of CVD was 9.5%. Individuals with CVD exhibited reduced sleep duration by 33 min (p
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- 2022
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19. Arterial bicarbonate is associated with hypoxic burden and uncontrolled hypertension in obstructive sleep apnea - The ESADA cohort
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Steiropoulos, P., Verbraecken, J., Petiet, E., Trakada, Georgia, Fietze, I., Penzel, T., Ludka, Ondrej, Bouloukaki, I., Schiza, S., McNicholas, W.T., Ryan, S., Riha, R.L., Kvamme, J.A., Grote, L., Hedner, J., Zou, D., Pevernagie, Dirk, Bailly, S., Pépin, J.L., Tamisier, R., Hein, H., Basoglu, O.K., Tasbakan, M.S., Buskova, J., Joppa, P., Staats, R., Testelmans, Dries, Gouveris, Haralampos, Ludwig, K., Lombardi, C., Parati, G., Bonsignore, M.R., Fanfulla, Francesco, Drummond, M., van Zeller, M., Randerath, W., Treml, Marcel, Dogas, Z., Pecotic, R., Pataka, A., Mihaicuta, S., Anttalainen, U., Saaresranta, T., Sliwinski, P., Zou, Ding, Grote, Ludger, Basoglu, Ozen K., Verbraecken, Johan, Schiza, Sophia, Sliwinski, Pawel, Steiropoulos, Paschalis, Lombardi, Carolina, Hein, Holger, Pépin, Jean-Louis, Parati, Gianfranco, McNicholas, Walter T., and Hedner, Jan
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- 2023
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20. Hellenic registry of patients with home mechanical ventilation (HR-HMV): profiling sleep Apnea–Hypopnea syndrome patients across Greece
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Vlasios K. Dimitriadis, Christina Alexopoulou, Anastasia Amfilochiou, Paschalis Steiropoulos, Georgia Trakada, Dimitra Siopi, Athanasia Pataka, Elpis Hatziagorou, Athanasios Konstandinidis, HR-HMV Data Curation Group, John Tsanakas, Venetia Tsara, and Pantelis Natsiavas
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Patient registries ,Home mechanical ventilation ,Chronic respiratory failure ,Sleep Apnea–Hypopnea syndrome (SAHS) ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Chronic respiratory conditions are a prominent public health issue and thus, building a patient registry might facilitate both policy decision making and improvement of clinical management processes. Hellenic Registry of patients with Home Mechanical Ventilation (HR-HMV) was initiated in 2017 and a web-based platform is used to support patient data collection. Eighteen hospital departments (including sleep labs) across Greece participate in this initiative, focusing on recording data for both children and adult patients supported by mechanical ventilation at home, including patients with Sleep Apnea–Hypopnea Syndrome (SAHS) under Positive Airway Pressure (PAP) therapy. Methods The HR-HMV initiative ultimately aims to provide a database for evidence-based care and policy making in this specific domain. To this end, a web information system was developed and data were manually collected by clinics and hospital departments. Legal and privacy issues (such as General Data Protection Rule compliance and technical information security measures) have been considered while designing the web application. Based on the collected data, an exploratory statistical report of SAHS patients in Greece is presented. Results Eleven out of the eighteen participating clinics and hospital departments have contributed with data by the time of the current study. More than 5000 adult and children patient records have been collected so far, the vast majority of which (i.e., 4900 patients) diagnosed with SAHS. Conclusion The development and maintenance of patient registries is a valuable tool for policy decision making, observational/epidemiological research and beyond (e.g., health technology assessment procedures). However, as all data collection and processing approaches, registries are also related with potential biases. Along these lines, strengths and limitations must be considered when interpreting the collected data, and continuous validation of the collected clinical data per se should be emphasized. Especially for Greece, where the lack of national registries is eminent, we argue that HR-HMV could be a useful tool for the development and the update of related policies regarding the healthcare services for patients with home mechanical ventilation support and SAHS patients, which could be useful for related initiatives at a European level as well.
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- 2022
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21. The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study
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Juanita A. Haagsma, Periklis Charalampous, Filippo Ariani, Anne Gallay, Kim Moesgaard Iburg, Evangelia Nena, Che Henry Ngwa, Alexander Rommel, Ausra Zelviene, Kedir Hussein Abegaz, Hanadi Al Hamad, Luciana Albano, Catalina Liliana Andrei, Tudorel Andrei, Ippazio Cosimo Antonazzo, Olatunde Aremu, Ashokan Arumugam, Alok Atreya, Avinash Aujayeb, Jose Luis Ayuso-Mateos, Luchuo Engelbert Bain, Maciej Banach, Till Winfried Bärnighausen, Francesco Barone-Adesi, Massimiliano Beghi, Derrick A. Bennett, Akshaya S. Bhagavathula, Félix Carvalho, Giulio Castelpietra, Ledda Caterina, Joht Singh Chandan, Rosa A. S. Couto, Natália Cruz-Martins, Giovanni Damiani, Anna Dastiridou, Andreas K. Demetriades, Diana Dias-da-Silva, Adeniyi Francis Fagbamigbe, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Pietro Ferrara, Florian Fischer, Urbano Fra.Paleo, Silvia Ghirini, James C. Glasbey, Ionela-Roxana Glavan, Nelson G. M. Gomes, Michal Grivna, Netanja I. Harlianto, Josep Maria Haro, M. Tasdik Hasan, Sorin Hostiuc, Ivo Iavicoli, Milena D. Ilic, Irena M. Ilic, Mihajlo Jakovljevic, Jost B. Jonas, Jacek Jerzy Jozwiak, Mikk Jürisson, Joonas H. Kauppila, Gbenga A. Kayode, Moien A. B. Khan, Adnan Kisa, Sezer Kisa, Ai Koyanagi, Manasi Kumar, Om P. Kurmi, Carlo La-Vecchia, Demetris Lamnisos, Savita Lasrado, Paolo Lauriola, Shai Linn, Joana A. Loureiro, Raimundas Lunevicius, Aurea Madureira-Carvalho, Enkeleint A. Mechili, Azeem Majeed, Ritesh G. Menezes, Alexios-Fotios A. Mentis, Atte Meretoja, Tomislav Mestrovic, Tomasz Miazgowski, Bartosz Miazgowski, Andreea Mirica, Mariam Molokhia, Shafiu Mohammed, Lorenzo Monasta, Francesk Mulita, Mukhammad David Naimzada, Ionut Negoi, Subas Neupane, Bogdan Oancea, Hans Orru, Adrian Otoiu, Nikita Otstavnov, Stanislav S. Otstavnov, Alicia Padron-Monedero, Songhomitra Panda-Jonas, Shahina Pardhan, Jay Patel, Paolo Pedersini, Marina Pinheiro, Ivo Rakovac, Chythra R. Rao, Salman Rawaf, David Laith Rawaf, Violet Rodrigues, Luca Ronfani, Dominic Sagoe, Francesco Sanmarchi, Milena M. Santric-Milicevic, Brijesh Sathian, Aziz Sheikh, Rahman Shiri, Siddharudha Shivalli, Inga Dora Sigfusdottir, Rannveig Sigurvinsdottir, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Catalin-Gabriel Smarandache, Bogdan Socea, Raúl A. R. C. Sousa, Paschalis Steiropoulos, Rafael Tabarés-Seisdedos, Marcos Roberto Tovani-Palone, Fimka Tozija, Sarah Van de Velde, Tommi Juhani Vasankari, Massimiliano Veroux, Francesco S. Violante, Vasiliy Vlassov, Yanzhong Wang, Ali Yadollahpour, Sanni Yaya, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Suzanne Polinder, and Marek Majdan
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Burden of disease ,Injuries ,Disability adjusted life years ,Mortality ,Europe ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Injury remains a major concern to public health in the European region. Previous iterations of the Global Burden of Disease (GBD) study showed wide variation in injury death and disability adjusted life year (DALY) rates across Europe, indicating injury inequality gaps between sub-regions and countries. The objectives of this study were to: 1) compare GBD 2019 estimates on injury mortality and DALYs across European sub-regions and countries by cause-of-injury category and sex; 2) examine changes in injury DALY rates over a 20 year-period by cause-of-injury category, sub-region and country; and 3) assess inequalities in injury mortality and DALY rates across the countries. Methods We performed a secondary database descriptive study using the GBD 2019 results on injuries in 44 European countries from 2000 to 2019. Inequality in DALY rates between these countries was assessed by calculating the DALY rate ratio between the highest-ranking country and lowest-ranking country in each year. Results In 2019, in Eastern Europe 80 [95% uncertainty interval (UI): 71 to 89] people per 100,000 died from injuries; twice as high compared to Central Europe (38 injury deaths per 100,000; 95% UI 34 to 42) and three times as high compared to Western Europe (27 injury deaths per 100,000; 95%UI 25 to 28). The injury DALY rates showed less pronounced differences between Eastern (5129 DALYs per 100,000; 95% UI: 4547 to 5864), Central (2940 DALYs per 100,000; 95% UI: 2452 to 3546) and Western Europe (1782 DALYs per 100,000; 95% UI: 1523 to 2115). Injury DALY rate was lowest in Italy (1489 DALYs per 100,000) and highest in Ukraine (5553 DALYs per 100,000). The difference in injury DALY rates by country was larger for males compared to females. The DALY rate ratio was highest in 2005, with DALY rate in the lowest-ranking country (Russian Federation) 6.0 times higher compared to the highest-ranking country (Malta). After 2005, the DALY rate ratio between the lowest- and the highest-ranking country gradually decreased to 3.7 in 2019. Conclusions Injury mortality and DALY rates were highest in Eastern Europe and lowest in Western Europe, although differences in injury DALY rates declined rapidly, particularly in the past decade. The injury DALY rate ratio of highest- and lowest-ranking country declined from 2005 onwards, indicating declining inequalities in injuries between European countries.
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- 2022
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22. Hellenic registry of patients with home mechanical ventilation (HR-HMV): profiling sleep Apnea–Hypopnea syndrome patients across Greece
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Dimitriadis, Vlasios K., Alexopoulou, Christina, Amfilochiou, Anastasia, Steiropoulos, Paschalis, Trakada, Georgia, Siopi, Dimitra, Pataka, Athanasia, Hatziagorou, Elpis, Konstandinidis, Athanasios, Tsanakas, John, Tsara, Venetia, and Natsiavas, Pantelis
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- 2022
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23. Author Correction: Self-perceived quality of sleep among COPD patients in Greece: the SLEPICO study
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Koulouris, Nikolaos, Dimakou, Katerina, Gourgoulianis, Konstantinos, Tzanakis, Nikolaos, Rapti, Aggeliki, Gaga, Mina, Georgatou, Niki, Steiropoulos, Paschalis, Karachristos, Christos, Gogali, Athena, Kalafatakis, Konstantinos, and Kostikas, Konstantinos
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- 2022
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24. The burden of injury in Central, Eastern, and Western European sub-region: a systematic analysis from the Global Burden of Disease 2019 Study
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Haagsma, Juanita A., Charalampous, Periklis, Ariani, Filippo, Gallay, Anne, Moesgaard Iburg, Kim, Nena, Evangelia, Ngwa, Che Henry, Rommel, Alexander, Zelviene, Ausra, Abegaz, Kedir Hussein, Al Hamad, Hanadi, Albano, Luciana, Liliana Andrei, Catalina, Andrei, Tudorel, Antonazzo, Ippazio Cosimo, Aremu, Olatunde, Arumugam, Ashokan, Atreya, Alok, Aujayeb, Avinash, Ayuso-Mateos, Jose Luis, Engelbert Bain, Luchuo, Banach, Maciej, Winfried Bärnighausen, Till, Barone-Adesi, Francesco, Beghi, Massimiliano, Bennett, Derrick A., Bhagavathula, Akshaya S., Carvalho, Félix, Castelpietra, Giulio, Caterina, Ledda, Chandan, Joht Singh, Couto, Rosa A. S., Cruz-Martins, Natália, Damiani, Giovanni, Dastiridou, Anna, Demetriades, Andreas K., Dias-da-Silva, Diana, Francis Fagbamigbe, Adeniyi, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferrara, Pietro, Fischer, Florian, Fra.Paleo, Urbano, Ghirini, Silvia, Glasbey, James C., Glavan, Ionela-Roxana, Gomes, Nelson G. M., Grivna, Michal, Harlianto, Netanja I., Haro, Josep Maria, Hasan, M. Tasdik, Hostiuc, Sorin, Iavicoli, Ivo, Ilic, Milena D., Ilic, Irena M., Jakovljevic, Mihajlo, Jonas, Jost B., Jerzy Jozwiak, Jacek, Jürisson, Mikk, Kauppila, Joonas H., Kayode, Gbenga A., Khan, Moien A. B., Kisa, Adnan, Kisa, Sezer, Koyanagi, Ai, Kumar, Manasi, Kurmi, Om P., La-Vecchia, Carlo, Lamnisos, Demetris, Lasrado, Savita, Lauriola, Paolo, Linn, Shai, Loureiro, Joana A., Lunevicius, Raimundas, Madureira-Carvalho, Aurea, Mechili, Enkeleint A., Majeed, Azeem, Menezes, Ritesh G., Mentis, Alexios-Fotios A., Meretoja, Atte, Mestrovic, Tomislav, Miazgowski, Tomasz, Miazgowski, Bartosz, Mirica, Andreea, Molokhia, Mariam, Mohammed, Shafiu, Monasta, Lorenzo, Mulita, Francesk, David Naimzada, Mukhammad, Negoi, Ionut, Neupane, Subas, Oancea, Bogdan, Orru, Hans, Otoiu, Adrian, Otstavnov, Nikita, Otstavnov, Stanislav S., Padron-Monedero, Alicia, Panda-Jonas, Songhomitra, Pardhan, Shahina, Patel, Jay, Pedersini, Paolo, Pinheiro, Marina, Rakovac, Ivo, Rao, Chythra R., Rawaf, Salman, Rawaf, David Laith, Rodrigues, Violet, Ronfani, Luca, Sagoe, Dominic, Sanmarchi, Francesco, Santric-Milicevic, Milena M., Sathian, Brijesh, Sheikh, Aziz, Shiri, Rahman, Shivalli, Siddharudha, Dora Sigfusdottir, Inga, Sigurvinsdottir, Rannveig, Yurievich Skryabin, Valentin, Aleksandrovna Skryabina, Anna, Smarandache, Catalin-Gabriel, Socea, Bogdan, Sousa, Raúl A. R. C., Steiropoulos, Paschalis, Tabarés-Seisdedos, Rafael, Roberto Tovani-Palone, Marcos, Tozija, Fimka, Van de Velde, Sarah, Juhani Vasankari, Tommi, Veroux, Massimiliano, Violante, Francesco S., Vlassov, Vasiliy, Wang, Yanzhong, Yadollahpour, Ali, Yaya, Sanni, Sergeevich Zastrozhin, Mikhail, Zastrozhina, Anasthasia, Polinder, Suzanne, and Majdan, Marek
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- 2022
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25. Self-perceived quality of sleep among COPD patients in Greece: the SLEPICO study
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Koulouris, Nikolaos, Dimakou, Katerina, Gourgoulianis, Konstantinos, Tzanakis, Nikolaos, Rapti, Aggeliki, Gaga, Mina, Georgatou, Niki, Steiropoulos, Paschalis, Karachristos, Christos, Gogali, Athena, Kalafatakis, Konstantinos, and Kostikas, Konstantinos
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- 2022
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26. Is COPD the Determinant Factor for Myocardial Injury and Cardiac Wall Stress in OSA Patients?
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Athanasios Voulgaris, Kostas Archontogeorgis, Ioulianos Apessos, Nikoleta Paxinou, Evangelia Nena, and Paschalis Steiropoulos
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chronic obstructive pulmonary disease ,obstructive sleep apnea ,overlap syndrome ,cardiovascular disease ,N-terminal pro-B-type natriuretic peptide ,high-sensitivity cardiac troponin T ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Evidence shows that COPD-OSA overlap syndrome (OS) is more frequently accompanied by cardiovascular disease (CVD) in comparison to either disease alone. The aim of the study was to explore whether patients with OS have a higher burden of subclinical myocardial injury and wall stress compared with OSA patients. Materials and Methods: Consecutive patients, without established CVD, underwent polysomnography and pulmonary function testing, due to suspected sleep-disordered breathing. An equal number of patients with OS (n = 53, with an apnea hypopnea index (AHI) > 5/h and FEV1/FVC < 0.7) and patients with OSA (n = 53, AHI > 5/h and FEV1/FVC > 0.7) were included in the study. The detection of asymptomatic myocardial injury and wall stress was performed via the assessment of serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), respectively. Results: OS patients were older (p < 0.001) and had worse hypoxemic parameters, namely average oxyhemoglobin saturation (SpO2) (p = 0.002) and time spent with SpO2 < 90% (p = 0.003) during sleep as well as daytime pO2 (p < 0.001), than patients with OSA. No difference was observed between groups in terms of Epworth Sleepiness Scale (p = 0.432) and AHI (p = 0.587). Both levels of hs-cTnT (14.2 (9.1–20.2) vs. 6.5 (5.6–8.7) pg/mL, p < 0.001) and NT-proBNP (93.1 (37.9–182.5) vs. 19.2 (8.3–35.4) pg/mL, p < 0.001) were increased in OS compared to OSA patients. Upon multivariate linear regression analysis, levels of NT-proBNP and hs-cTnT correlated with age and average SpO2 during sleep. Conclusions: Our study demonstrated higher levels of hs-cTnT and NT-proBNP in OS patients, indicating an increased probability of subclinical myocardial injury and wall stress, compared with OSA individuals.
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- 2023
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27. The Influence of CPAP Therapy on Basal Metabolic Rate and Physical Activity in Obese Patients with Obstructive Sleep Apnea
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Dimitra Siopi and Paschalis Steiropoulos
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obstructive sleep apnea ,obesity ,basal metabolic rate ,physical activity ,CPAP treatment ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Background: Energy balance in Obstructive Sleep Apnea (OSA), a disease closely related to obesity, is disturbed, and physical activity levels are impaired. The role of Continuous Positive Airway Pressure treatment (CPAP) in alleviating the disruptions mentioned above is questioned. The objective of this study is to explore changes in energy expenditure (EE) and physical activity (PA) in obese patients with OSA after CPAP treatment. Methods: An assessment of Basal Metabolic Rate (BMR) via indirect calorimetry (IC) was performed on 24 obese patients (male in the majority (87.5%), mean age of 52.4 ± 9.8 years), newly diagnosed with moderate–severe OSA by polysomnography, at 4-time points: at baseline, at CPAP titration, at the 1-month and the 3-month follow up. Physical activity levels were subjectively estimated using the International Questionnaire of Physical Activity (IPAQ) before and after 3 months of adherent CPAP application. Results: BMR significantly decreased after CPAP treatment (1926 ± 537.8 kcal/d at baseline, 1790 ± 493.7 kcal/d at CPAP initiation, 1680.3 ± 600.8 kcal/d at 1 month, and 1581.3 ± 478.9 kcal/d at 3 months follow up (p < 0.001)). No significant changes in IPAQ were observed over time: baseline median IPAQ: 3894 (1487.5–11,755.5) total MET·min·wk−1, 3-month median IPAQ: 3900 (1512–11,824.5) total MET·min·wk−1. Conclusions: CPAP has an appreciable time effect on the BMR of obese patients with moderate–severe OSA. However, this change is not accompanied by a significant increase in physical activity levels.
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- 2023
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28. A Clinical Approach of Allergic Rhinitis in Children
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Ioannis Goniotakis, Evanthia Perikleous, Sotirios Fouzas, Paschalis Steiropoulos, and Emmanouil Paraskakis
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allergic rhinitis ,asthma ,children ,Pediatrics ,RJ1-570 - Abstract
Allergic rhinitis is an important disease with a global footprint and a growing prevalence, affecting children and adults. Although it is commonly under-diagnosed and under-treated, it causes important social and economic effects (diminished quality of life, poor academic performance, escalated medical visits, heightened medication usage, and effects in other chronic conditions, e.g., asthma). It is characterized by distinctive, easily identifiable symptoms (sneezing, nasal discharge, nasal congestion, nasal–eye–palatal itching) and indirect accompanying indicators (fatigue and decreased school performance). The classification of allergic rhinitis hinges upon its nature and chronic distribution (seasonal or perennial) and its intensity, which spans from mild to moderate and severe. The diagnostic process primarily relies upon recognizing key clinical indicators, evaluating historical records, and considering risk factors. It is supported by abnormal laboratory findings, like in vitro allergen-specific IgE tests (enzyme immunoassay—EIA, chemiluminense immunoassay—CLIA) or in vivo skin prick tests for specific allergens. In the differential diagnosis, other chronic diseases manifesting with chronic rhinitis should be excluded (e.g., rhinosinusitis, chronic non-allergic rhinitis, rhinitis triggered by medications). The treatment of allergic rhinitis in children is mainly chronic and is focused on allergen exposure prevention, drug therapy, and immunotherapy in severe cases. Locally administered intranasal corticosteroids are the cornerstone of therapy. They are safe, effective, and have a favorable safety profile even during long-term use. Choosing a suitable intranasal corticosteroid drug with low systemic bioavailability makes long-term treatment even safer. Combinations of intranasal corticosteroids and H1 antihistamines are available in several countries and are widely used in more severe cases and the presence of year-round symptoms. Adding newer-generation oral H1-antihistamines broadens the available therapeutic inventory without significant effects compared to using previous-generation, once widely available, H1-antihistamines. Treatment of allergic rhinitis is complex and multi-dimensional, requiring an effective approach by a specialized group of specialized pediatricians, and is severely affected by the concurrent presence or development of other diseases in the spectrum of allergic diseases (conjunctivitis, asthma).
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- 2023
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29. Self-perceived quality of sleep among COPD patients in Greece: the SLEPICO study
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Nikolaos Koulouris, Katerina Dimakou, Konstantinos Gourgoulianis, Nikolaos Tzanakis, Aggeliki Rapti, Mina Gaga, Niki Georgatou, Paschalis Steiropoulos, Christos Karachristos, Athena Gogali, Konstantinos Kalafatakis, and Konstantinos Kostikas
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Medicine ,Science - Abstract
Abstract Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide accompanied by a substantial social and economic burden for the patient and the society. Poor sleep quality among COPD patients is frequently unnoticed and unaddressed by physicians and patients themselves, although it is a major source of further deterioration of these patients’ quality of life. The aim of the present study was to record the quality of sleep in COPD patients among the Greek population and correlate these findings with various features of these patients, using the COPD and Asthma Sleep Impact Scale (CASIS). This was a cross-sectional observational study. Forty different variables (demographics, vital sign measurements, COPD-related medical history parameters, comorbidities, CASIS questionnaire results, COPD assessment test, COPD severity based on spirometry measurements, COPD stage based on the ABCD assessment approach, inhaled COPD treatment report) were collected from 3454 nation-wide COPD patients (Greece). The study sample consisted of COPD patients, mainly male (73%) with a median age of 69 years and a median BMI of 27.2. More than half of COPD patients (60.6%) suffered from moderate disease severity and 23.8% from severe disease, while less than half (42.1%) suffered from at least one exacerbation of the disease over the last year prior study enrollment. About 14% reported frequent to very frequent issues affecting their sleep quality, between a fourth and a third of them reported occasional night sleep disturbances, and at least half of them reported no or very infrequent problems in their night sleep. Our study indicates that the COPD assessment test (CAT) and the spirometry-based disease severity can predict the poorness in the quality of sleep (F2,3451 = 1397.5, p
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- 2022
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30. Dream Recall/Affect and Cortisol: An Exploratory Study
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Alexandros S. Triantafyllou, Ioannis Ilias, Nicholas-Tiberio Economou, Athina Pappa, Eftychia Koukkou, and Paschalis Steiropoulos
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dreams ,dream recall ,dream affect ,cortisol ,menstrual cycle ,Medicine - Abstract
The effect of cortisol on dreams has been scarcely studied. The aim of this exploratory study was to assess the possible effect of cortisol levels on dream recall/affect, considering, in female subjects, their menstrual cycle phase. Fifteen men and fifteen women were recruited. Saliva samples were used for the detection of cortisol levels. Participants were instructed to provide four saliva samples, during three consecutive days. After awakening, on the second and third day, they were asked whether they could recall the previous night’s dreams and whether these were pleasant or unpleasant. Female subjects followed this procedure twice: firstly, during the luteal phase and, secondly, during the follicular phase of the menstrual cycle. Subjects with higher evening or higher morning cortisol levels tended to show increased dream recall; a non-statistically significant association between morning cortisol levels and positive dream affect was also found. This association acquired statistical significance for salivary morning cortisol levels exceeding the upper normal level of 19.1 nmol/L (OR: 4.444, 95% CI: 1.108–17.830, p-value: 0.039). No connection between menstrual cycle stages and dream recall/affect was detected. In conclusion, cortisol may be a crucial neuromodulator, affecting dream recall and content. Therefore, its effects on sleep and dreams should be further studied.
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- 2022
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31. The presence of insomnia and depression contributes to the acceptance of an initial treatment trial of continuous positive airway pressure therapy in patients with obstructive sleep apnea
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Drakou, Theodora, Steiropoulos, Pashalis, Saroglou, Maria, Georgopoulou, Athina, Kazis, Dimitris, Papagiannopoulos, Sotiris, Porpodis, Konstantinos, and Tryfon, Stavros
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- 2021
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32. The association between beta-blocker therapy and daytime sleepiness in obstructive sleep apnoea
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Meszaros, Martina, Mathioudakis, Alexander G., Xanthoudaki, Maria, Sircu, Victoria, Nena, Evangelia, Vestbo, Jørgen, Corlateanu, Alexandru, Steiropoulos, Paschalis, and Bikov, Andras
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- 2021
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33. Recent insights in the role of biomarkers in severe asthma management
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Evangelia Fouka, Kalliopi Domvri, Foteini Gkakou, Maria Alevizaki, Paschalis Steiropoulos, Despoina Papakosta, and Konstantinos Porpodis
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biomarkers ,severe asthma ,T2 asthma ,non-T2 airway inflammation ,omics ,microbiome & dysbiosis ,Medicine (General) ,R5-920 - Abstract
Contemporary asthma management requires a proactive and individualized approach, combining precision diagnosis and personalized treatment. The introduction of biologic therapies for severe asthma to everyday clinical practice, increases the need for specific patient selection, prediction of outcomes and monitoring of these costly and long-lasting therapies. Several biomarkers have been used in asthma in disease identification, prediction of asthma severity and prognosis, and response to treatment. Novel advances in the area of personalized medicine regarding disease phenotyping and endotyping, encompass the development and application of reliable biomarkers, accurately quantified using robust and reproducible methods. The availability of powerful omics technologies, together with integrated and network-based genome data analysis, and microbiota changes quantified in serum, body fluids and exhaled air, will lead to a better classification of distinct phenotypes or endotypes. Herein, in this review we discuss on currently used and novel biomarkers for the diagnosis and treatment of asthma.
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- 2022
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34. Niclosamide Attenuates Inflammation-Associated Profibrotic Responses in Human Subepithelial Lung Myofibroblasts
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Michail Spathakis, Gesthimani Tarapatzi, Eirini Filidou, Leonidas Kandilogiannakis, Evangelos Karatzas, Paschalis Steiropoulos, Dimitrios Mikroulis, George M. Spyrou, Vangelis G. Manolopoulos, George Kolios, and Konstantinos Arvanitidis
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niclosamide ,myofibroblasts ,pulmonary fibrosis ,inflammation ,collagen ,Biology (General) ,QH301-705.5 - Abstract
Niclosamide is a commonly used helminthicidic drug for the treatment of human parasitosis by helminths. Recently, efforts have been focusing on repurposing this drug for the treatment of other diseases, such as idiopathic pulmonary fibrosis. Subepithelial lung myofibroblasts (SELMs) isolated from tissue biopsies of patients undergoing surgery for lung cancer were stimulated with TNF-α (50 ng/mL), IL-1α (5 ng/mL), added alone or in combination, and TGF-β1 (5 ng/mL). After treatment with niclosamide at 30 nM and 100 nM concentrations, expression of collagen type I, collagen type III, and fibronectin was studied by total RNA isolation and qRT-PCR and protein collagen secretion with the use of Sircol collagen assay. The migration of SELMs was assessed by a wound-healing assay. Niclosamide had no effect on baseline SELM fibrotic factor expression. When stimulated with TGF-β1, IL-1α, and/or TNF-α, SELM expression of collagen type I, type III, and fibronectin were upregulated, as was the secretion of total collagen in the culture medium. Treatment with niclosamide attenuated the effects of cytokine stimulation leading to a notable decrease in the mRNA expression of collagen type I, type III, and fibronectin in a concentration-dependent manner. SELM collagen secretion was also reduced by niclosamide at 100 nM concentration when examined at the protein level. Migration of both TGF-β1 stimulated and unstimulated SELMs was also inhibited by niclosamide. In this study, we highlight the anti-fibrotic properties of niclosamide on SELMs under stimulation with pro-fibrotic and pro-inflammatory cytokines, thus proposing this compound as a possible new therapeutic agent against lung fibrosis.
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- 2023
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35. Acute Exacerbations of Interstitial Lung Diseases: Focus on Biomarkers
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Fotios Drakopanagiotakis, Philipp Markart, and Paschalis Steiropoulos
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interstitial lung diseases ,acute exacerbations ,biomarkers ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Interstitial lung diseases (ILDs) are a large group of pulmonary disorders characterized histologically by the cardinal involvement of the pulmonary interstitium. The prototype of ILDs is idiopathic pulmonary fibrosis (IPF), an incurable disease characterized by progressive distortion and loss of normal lung architecture through unchecked collagen deposition. Acute exacerbations are dramatic events during the clinical course of ILDs, associated with high morbidity and mortality. Infections, microaspiration, and advanced lung disease might be involved in the pathogenesis of acute exacerbations. Despite clinical scores, the prediction of the onset and outcome of acute exacerbations is still inaccurate. Biomarkers are necessary to characterize acute exacerbations better. We review the evidence for alveolar epithelial cell, fibropoliferation, and immunity molecules as potential biomarkers for acute exacerbations of interstitial lung disease.
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- 2023
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36. Vitamin D deficiency in patients evaluated for obstructive sleep apnea: is it associated with disease severity?
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Bouloukaki, Izolde, Tsiligianni, Ioanna, Mermigkis, Charalampos, Bonsignore, Marisa R., Markakis, Manolis, Pataka, Athanasia, Steiropoulos, Paschalis, Ermidou, Christina, Alexaki, Ioanna, Tzanakis, Nikolaos, and Schiza, Sophia
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- 2021
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37. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
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Schumacher, A, Kyu, H, Aali, A, Abbafati, C, Abbas, J, Abbasgholizadeh, R, Abbasi, M, Abbasian, M, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdollahi, M, Abdoun, M, Abdullahi, A, Abdurehman, A, Abebe, M, Abedi, A, Abegaz, T, Abeldaño Zuñiga, R, Abhilash, E, Abiodun, O, Aboagye, R, Abolhassani, H, Abouzid, M, Abreu, L, Abrha, W, Abrigo, M, Abtahi, D, Abu Rumeileh, S, Abu-Rmeileh, N, Aburuz, S, Abu-Zaid, A, Acuna, J, Adair, T, Addo, I, Adebayo, O, Adegboye, O, Adekanmbi, V, Aden, B, Adepoju, A, Adetunji, C, Adeyeoluwa, T, Adeyomoye, O, Adha, R, Adibi, A, Adikusuma, W, Adnani, Q, Adra, S, Afework, A, Afolabi, A, Afraz, A, Afyouni, S, Afzal, S, Agasthi, P, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, M, Ahmad, T, Ahmadi, K, Ahmadzade, A, Ahmadzade, M, Ahmed, A, Ahmed, H, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Aji, B, Ajumobi, O, Akalu, G, Akara, E, Akinosoglou, K, Akkala, S, Akyirem, S, Al Hamad, H, Al Hasan, S, Al Homsi, A, Al Qadire, M, Ala, M, Aladelusi, T, AL-Ahdal, T, Alalalmeh, S, Al-Aly, Z, Alam, K, Alam, M, Alam, Z, Al-amer, R, Alanezi, F, Alanzi, T, Albashtawy, M, Albataineh, M, Aldridge, R, Alemi, S, Al-Eyadhy, A, Al-Gheethi, A, Alhabib, K, Alhalaiqa, F, Al-Hanawi, M, Ali, A, Ali, B, Ali, H, Ali, M, Ali, R, Ali, S, Ali, Z, Alian Samakkhah, S, Alicandro, G, Alif, S, Aligol, M, Alimi, R, Aliyi, A, Al-Jumaily, A, Aljunid, S, Almahmeed, W, Al-Marwani, S, Al-Maweri, S, Almazan, J, Al-Mekhlafi, H, Almidani, O, Alomari, M, Alonso, N, Alqahtani, J, Alqutaibi, A, Al-Sabah, S, Altaf, A, Al-Tawfiq, J, Altirkawi, K, Alvi, F, Alwafi, H, Al-Worafi, Y, Aly, H, Alzoubi, K, Amare, A, Ameyaw, E, Amhare, A, Amin, T, Amindarolzarbi, A, Aminian Dehkordi, J, Amiri, S, Amu, H, Amugsi, D, Amzat, J, Ancuceanu, R, Anderlini, D, Andrade, P, Andrei, C, Andrei, T, Angappan, D, Anil, A, Anjum, A, Antony, C, Antriyandarti, E, Anuoluwa, I, Anwar, S, Anyasodor, A, Appiah, S, Aqeel, M, Arabloo, J, Arabzadeh Bahri, R, Arab-Zozani, M, Arafat, M, Araújo, A, Aravkin, A, Aremu, A, Ariffin, H, Aripov, T, Armocida, B, Arooj, M, Artamonov, A, Artanti, K, Arulappan, J, Aruleba, I, Aruleba, R, Arumugam, A, Asaad, M, Asgary, S, Ashemo, M, Ashraf, M, Asika, M, Athari, S, Atout, M, Atreya, A, Attia, S, Aujayeb, A, Avan, A, Awotidebe, A, Ayala Quintanilla, B, Ayanore, M, Ayele, G, Ayuso-Mateos, J, Ayyoubzadeh, S, Azadnajafabad, S, Azhar, G, Aziz, S, Azzam, A, Babashahi, M, Babu, A, Badar, M, Badawi, A, Badiye, A, Baghdadi, S, Bagheri, N, Bagherieh, S, Bah, S, Bahadorikhalili, S, Bai, J, Bai, R, Baker, J, Bakkannavar, S, Bako, A, Balakrishnan, S, Balogun, S, Baltatu, O, Bam, K, Banach, M, Bandyopadhyay, S, Banik, B, Banik, P, Bansal, H, Barati, S, Barchitta, M, Bardhan, M, Barker-Collo, S, Barone-Adesi, F, Barqawi, H, Barr, R, Barrero, L, Basharat, Z, Bashir, A, Bashiru, H, Baskaran, P, Basnyat, B, Bassat, Q, Basso, J, Basu, S, Batra, K, Batra, R, Baune, B, Bayati, M, Bayileyegn, N, Beaney, T, Bedi, N, Begum, T, Behboudi, E, Behnoush, A, Beiranvand, M, Bejarano Ramirez, D, Belgaumi, U, Bell, M, Bello, A, Bello, M, Bello, O, Belo, L, Beloukas, A, Bendak, S, Bennett, D, Bensenor, I, Benzian, H, Berezvai, Z, Berman, A, Bermudez, A, Bettencourt, P, Beyene, H, Beyene, K, Bhagat, D, Bhagavathula, A, Bhala, N, Bhalla, A, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, V, Bhatti, G, Bhatti, J, Bhatti, M, Bhatti, R, Bhutta, Z, Bikbov, B, Binmadi, N, Bintoro, B, Biondi, A, Bisignano, C, Bisulli, F, Biswas, A, Biswas, R, Bitaraf, S, Bjørge, T, Bleyer, A, Boampong, M, Bodolica, V, Bodunrin, A, Bolarinwa, O, Bonakdar Hashemi, M, Bonny, A, Bora, K, Bora Basara, B, Borodo, S, Borschmann, R, Botero Carvajal, A, Bouaoud, S, Boudalia, S, Boyko, E, Bragazzi, N, Braithwaite, D, Brenner, H, Britton, G, Browne, A, Brunoni, A, Bulamu, N, Bulto, L, Buonsenso, D, Burkart, K, Burns, R, Burugina Nagaraja, S, Busse, R, Bustanji, Y, Butt, Z, Caetano dos Santos, F, Cai, T, Calina, D, Cámera, L, Campos, L, Campos-Nonato, I, Cao, C, Cardenas, C, Cárdenas, R, Carr, S, Carreras, G, Carrero, J, Carugno, A, Carvalho, F, Carvalho, M, Castaldelli-Maia, J, Castañeda-Orjuela, C, Castelpietra, G, Catalá-López, F, Catapano, A, Cattaruzza, M, Caye, A, Cederroth, C, Cembranel, F, Cenderadewi, M, Cercy, K, Cerin, E, Cevik, M, Chacón-Uscamaita, P, Chahine, Y, Chakraborty, C, Chan, J, Chang, C, Charalampous, P, Charan, J, Chattu, V, Chatzimavridou-Grigoriadou, V, Chavula, M, Cheema, H, Chen, A, Chen, H, Chen, L, Chen, M, Chen, S, Cherbuin, N, Chew, D, Chi, G, Chirinos-Caceres, J, Chitheer, A, Cho, S, Cho, W, Chong, B, Chopra, H, Choudhary, R, Chowdhury, R, Chu, D, Chukwu, I, Chung, E, Chung, S, Cini, K, Clark, C, Coberly, K, Columbus, A, Comfort, H, Conde, J, Conti, S, Cortesi, P, Costa, V, Cousin, E, Cowden, R, Criqui, M, Cruz-Martins, N, Culbreth, G, Cullen, P, Cunningham, M, da Silva e Silva, D, Dadana, S, Dadras, O, Dai, Z, Dalal, K, Dalli, L, Damiani, G, D'Amico, E, Daneshvar, S, Darwesh, A, Das, J, Das, S, Dash, N, Dashti, M, Dávila-Cervantes, C, Davis Weaver, N, Davletov, K, De Leo, D, Debele, A, Degenhardt, L, Dehbandi, R, Deitesfeld, L, Delgado-Enciso, I, Delgado-Ortiz, L, Demant, D, Demessa, B, Demetriades, A, Deng, X, Denova-Gutiérrez, E, Deribe, K, Dervenis, N, Des Jarlais, D, Desai, H, Desai, R, Deuba, K, Devanbu, V, Dey, S, Dhali, A, Dhama, K, Dhimal, M, Dhingra, S, Dias da Silva, D, Diaz, D, Dima, A, Ding, D, Dirac, M, Dixit, A, Dixit, S, Do, T, do Prado, C, Dodangeh, M, Dokova, K, Dolecek, C, Dorsey, E, dos Santos, W, Doshi, R, Doshmangir, L, Douiri, A, Dowou, R, Driscoll, T, Dsouza, H, Dube, J, Dumith, S, Dunachie, S, Duncan, B, Duraes, A, Duraisamy, S, Durojaiye, O, Dutta, S, Dzianach, P, Dziedzic, A, Ebenezer, O, Eboreime, E, Ebrahimi, A, Echieh, C, Ed-Dra, A, Edinur, H, Edvardsson, D, Edvardsson, K, Efendi, D, Efendi, F, Eghdami, S, Eikemo, T, Eini, E, Ekholuenetale, M, Ekpor, E, Ekundayo, T, El Arab, R, El Morsi, D, El Sayed Zaki, M, El Tantawi, M, Elbarazi, I, Elemam, N, Elgar, F, Elgendy, I, Elgohary, G, Elhabashy, H, Elhadi, M, Elmeligy, O, Elshaer, M, Elsohaby, I, Emami Zeydi, A, Emamverdi, M, Emeto, T, Engelbert Bain, L, Erkhembayar, R, Eshetie, T, Eskandarieh, S, Espinosa-Montero, J, Estep, K, Etaee, F, Eze, U, Fabin, N, Fadaka, A, Fagbamigbe, A, Fahimi, S, Falzone, L, Farinha, C, Faris, M, Farjoud Kouhanjani, M, Faro, A, Farrokhpour, H, Fatehizadeh, A, Fattahi, H, Fauk, N, Fazeli, P, Feigin, V, Fekadu, G, Fereshtehnejad, S, Feroze, A, Ferrante, D, Ferrara, P, Ferreira, N, Fetensa, G, Filip, I, Fischer, F, Flavel, J, Flaxman, A, Flor, L, Florin, B, Folayan, M, Foley, K, Fomenkov, A, Force, L, Fornari, C, Foroutan, B, Foschi, M, Francis, K, Franklin, R, Freitas, A, Friedman, J, Friedman, S, Fukumoto, T, Fuller, J, Gaal, P, Gadanya, M, Gaihre, S, Gaipov, A, Gakidou, E, Galali, Y, Galehdar, N, Gallus, S, Gan, Q, Gandhi, A, Ganesan, B, Garg, J, Gau, S, Gautam, P, Gautam, R, Gazzelloni, F, Gebregergis, M, Gebrehiwot, M, Gebremariam, T, Gerema, U, Getachew, M, Getachew, T, Gething, P, Ghafourifard, M, Ghahramani, S, Ghailan, K, Ghajar, A, Ghanbarnia, M, Ghasemi, M, Ghasemzadeh, A, Ghassemi, F, Ghazy, R, Ghimire, S, Gholamian, A, Gholamrezanezhad, A, Ghorbani Vajargah, P, Ghozali, G, Ghozy, S, Ghuge, A, Gialluisi, A, Gibson, R, Gil, A, Gill, P, Gill, T, Gillum, R, Ginindza, T, Girmay, A, Glasbey, J, Gnedovskaya, E, Göbölös, L, Goel, A, Goldust, M, Golechha, M, Goleij, P, Golestanfar, A, Golinelli, D, Gona, P, Goudarzi, H, Goudarzian, A, Goyal, A, Greenhalgh, S, Grivna, M, Guarducci, G, Gubari, M, Gudeta, M, Guha, A, Guicciardi, S, Gunawardane, D, Gunturu, S, Guo, C, Gupta, A, Gupta, B, Gupta, I, Gupta, R, Gupta, S, Gupta, V, Gutiérrez, R, Habibzadeh, F, Habibzadeh, P, Hachinski, V, Haddadi, M, Haddadi, R, Haep, N, Hajj Ali, A, Halboub, E, Halim, S, Hall, B, Haller, S, Halwani, R, Hamadeh, R, Hamagharib Abdullah, K, Hamidi, S, Hamiduzzaman, M, Hammoud, A, Hanifi, N, Hankey, G, Hannan, M, Haque, M, Harapan, H, Haro, J, Hasaballah, A, Hasan, F, Hasan, I, Hasan, M, Hasani, H, Hasanian, M, Hasanpour- Dehkordi, A, Hassan, A, Hassanian-Moghaddam, H, Hassanipour, S, Haubold, J, Havmoeller, R, Hay, S, Hbid, Y, Hebert, J, Hegazi, O, Heidari, G, Heidari, M, Heidari-Foroozan, M, Heidari-Soureshjani, R, Helfer, B, Herteliu, C, Hesami, H, Hettiarachchi, D, Heyi, D, Hezam, K, Hiraike, Y, Hoffman, H, Holla, R, Horita, N, Hossain, M, Hossain, S, Hosseini, M, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hsairi, M, Hsieh, V, Hu, C, Huang, J, Huda, M, Hugo, F, Hultström, M, Hussain, J, Hussain, S, Hussein, N, Huy, L, Huynh, H, Hwang, B, Ibitoye, S, Idowu, O, Ijo, D, Ikuta, K, Ilaghi, M, Ilesanmi, O, Ilic, I, Ilic, M, Immurana, M, Inbaraj, L, Iradukunda, A, Iravanpour, F, Iregbu, K, Islam, M, Islam, S, Islami, F, Ismail, N, Isola, G, Iwagami, M, Iwu, C, Iwu-Jaja, C, Iyer, M, J, L, Jaafari, J, Jacob, L, Jacobsen, K, Jadidi-Niaragh, F, Jafarinia, M, Jaggi, K, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jain, A, Jain, N, Jairoun, A, Jakovljevic, M, Jalilzadeh Yengejeh, R, Jamshidi, E, Jani, C, Janko, M, Jatau, A, Jayapal, S, Jayaram, S, Jeganathan, J, Jema, A, Jemere, D, Jeong, W, Jha, A, Jha, R, Ji, J, Jiang, H, Jin, Y, Johnson, O, Jomehzadeh, N, Jones, D, Joo, T, Joseph, A, Joseph, N, Joshua, C, Jozwiak, J, Jürisson, M, Kaambwa, B, Kabir, A, Kabir, H, Kabir, Z, Kadashetti, V, Kahe, F, Kakodkar, P, Kalani, R, Kalankesh, L, Kaliyadan, F, Kalra, S, Kamath, A, Kamireddy, A, Kanagasabai, T, Kandel, H, Kanmiki, E, Kanmodi, K, Kantar, R, Kapoor, N, Karajizadeh, M, Karami Matin, B, Karanth, S, Karaye, I, Karim, A, Karimi, H, Karimi, S, Karimi Behnagh, A, Karkhah, S, Karna, A, Kashoo, F, Kasraei, H, Kassaw, N, Kassebaum, N, Kassel, M, Katamreddy, A, Katikireddi, S, Katoto, P, Kauppila, J, Kaur, N, Kaydi, N, Kayibanda, J, Kayode, G, Kazemi, F, Kazemian, S, Kazeminia, S, Keikavoosi-Arani, L, Keller, C, Kempen, J, Kerr, J, Kesse-Guyot, E, Keykhaei, M, Khadembashiri, M, Khafaie, M, Khajuria, H, Khalafi, M, Khalaji, A, Khalid, N, Khalil, I, Khamesipour, F, Khan, A, Khan, G, Khan, I, Khan, M, Khan, T, Khan suheb, M, Khanmohammadi, S, Khatab, K, Khatami, F, Khavandegar, A, Khayat Kashani, H, Kheirallah, K, Khidri, F, Khodadoust, E, Khormali, M, Khosrowjerdi, M, Khubchandani, J, Khusun, H, Kifle, Z, Kim, G, Kim, J, Kimokoti, R, Kinzel, K, Kiross, G, Kisa, A, Kisa, S, Kiss, J, Kivimäki, M, Klu, D, Knudsen, A, Kolahi, A, Kompani, F, Koren, G, Kosen, S, Kostev, K, Kotnis, A, Koul, P, Koulmane Laxminarayana, S, Koyanagi, A, Kravchenko, M, Krishan, K, Krishna, H, Krishnamoorthy, V, Krishnamoorthy, Y, Krohn, K, Kuate Defo, B, Kubeisy, C, Kucuk Bicer, B, Kuddus, M, Kuitunen, I, Kujan, O, Kulimbet, M, Kulkarni, V, Kumar, A, Kumar, H, Kumar, N, Kumar, R, Kumar, S, Kumari, M, Kurmanova, A, Kurmi, O, Kusnali, A, Kusuma, D, Kutluk, T, Kuttikkattu, A, Kyei, E, Kyriopoulos, I, La Vecchia, C, Ladan, M, Laflamme, L, Lahariya, C, Lahmar, A, Lai, D, Laksono, T, Lal, D, Lalloo, R, Lallukka, T, Lám, J, Lamnisos, D, Lan, T, Lanfranchi, F, Langguth, B, Lansingh, V, Laplante-Lévesque, A, Larijani, B, Larsson, A, Lasrado, S, Latief, K, Latif, M, Latifinaibin, K, Lauriola, P, Le, L, Le, N, Le, T, Lee, M, Lee, P, Lee, S, Lee, W, Lee, Y, Legesse, S, Leigh, J, Lenzi, J, Leong, E, Lerango, T, Li, M, Li, W, Li, X, Li, Y, Li, Z, Libra, M, Ligade, V, Likaka, A, Lim, L, Lin, R, Lin, S, Lioutas, V, Listl, S, Liu, J, Liu, S, Liu, X, Livingstone, K, Llanaj, E, Lo, C, Loreche, A, Lorenzovici, L, Lotfi, M, Lotfizadeh, M, Lozano, R, Lubinda, J, Lucchetti, G, Lugo, A, Lunevicius, R, Ma, J, Ma, S, Ma, Z, Mabrok, M, Machairas, N, Machoy, M, Madsen, C, Magaña Gómez, J, Maghazachi, A, Maharaj, S, Maharjan, P, Mahjoub, S, Mahmoud, M, Mahmoudi, E, Mahmoudi, M, Makram, O, Malagón-Rojas, J, Malakan Rad, E, Malekzadeh, R, Malhotra, A, Malhotra, K, Malik, A, Malik, I, Malinga, L, Malta, D, Mamun, A, Manla, Y, Mannan, F, Mansoori, Y, Mansour, A, Mansouri, V, Mansournia, M, Mantovani, L, Marasini, B, Marateb, H, Maravilla, J, Marconi, A, Mardi, P, Marino, M, Marjani, A, Marrugo Arnedo, C, Martinez-Guerra, B, Martinez-Piedra, R, Martins, C, Martins-Melo, F, Martorell, M, Marx, W, Maryam, S, Marzo, R, Mate, K, Matei, C, Mathioudakis, A, Maude, R, Maugeri, A, May, E, Mayeli, M, Mazaheri, M, Mazidi, M, Mazzotti, A, Mcalinden, C, Mcgrath, J, Mckee, M, Mckowen, A, Mclaughlin, S, Mcphail, M, Mcphail, S, Mechili, E, Mediratta, R, Meena, J, Mehari, M, Mehlman, M, Mehra, R, Mehrabani-Zeinabad, K, Mehrabi Nasab, E, Mehrotra, R, Mekonnen, M, Mendoza, W, Menezes, R, Mengesha, E, Mensah, G, Mensah, L, Mentis, A, Meo, S, Meretoja, A, Meretoja, T, Mersha, A, Mesfin, B, Mestrovic, T, Mhlanga, A, Mhlanga, L, Mi, T, Micha, G, Michalek, I, Miller, T, Mindlin, S, Minelli, G, Minh, L, Mini, G, Minja, N, Mirdamadi, N, Mirghafourvand, M, Mirica, A, Mirinezhad, S, Mirmosayyeb, O, Mirutse, M, Mirza-Aghazadeh-Attari, M, Mirzaei, M, Misgana, T, Misra, S, Mitchell, P, Mithra, P, Mittal, C, Mittal, M, Moazen, B, Mohamed, A, Mohamed, J, Mohamed, M, Mohamed, N, Mohammad-Alizadeh-Charandabi, S, Mohammadi, S, Mohammadian-Hafshejani, A, Mohammad-pour, S, Mohammadshahi, M, Mohammed, M, Mohammed, S, Mojiri-forushani, H, Mokdad, A, Mokhtarzadehazar, P, Momenzadeh, K, Momtazmanesh, S, Monasta, L, Moni, M, Montazeri, F, Moodi Ghalibaf, A, Moradi, M, Moradi, Y, Moradi-Lakeh, M, Moradinazar, M, Moradpour, F, Moraga, P, Morawska, L, Moreira, R, Morovatdar, N, Morrison, S, Morze, J, Mosaddeghi Heris, R, Mosser, J, Mossialos, E, Mostafavi, H, Mostofinejad, A, Mougin, V, Mouodi, S, Mousavi, P, Mousavi, S, Mousavi Khaneghah, A, Mpundu-Kaambwa, C, Mrejen, M, Mubarik, S, Muccioli, L, Mueller, U, Mughal, F, Mukherjee, S, Mukoro, G, Mulita, A, Mulita, F, Muniyandi, M, Munjal, K, Musaigwa, F, Musallam, K, Mustafa, G, Muthu, S, Muthupandian, S, Myung, W, Nabhan, A, Nafukho, F, Nagarajan, A, Naghavi, M, Naghavi, P, Naik, G, Naimzada, M, Nair, S, Nair, T, Najmuldeen, H, Naldi, L, Nangia, V, Nargus, S, 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- Published
- 2024
38. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
- Author
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Vollset, S, Ababneh, H, Abate, Y, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbastabar, H, Abd Al Magied, A, Abd ElHafeez, S, Abdelkader, A, Abdelmasseh, M, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdullahi, A, Abebe, M, Abiodun, O, Aboagye, R, Abolhassani, H, Abouzid, M, Aboye, G, Abreu, L, Absalan, A, Abualruz, H, Abubakar, B, Abukhadijah, H, Addolorato, G, Adekanmbi, V, Adetunji, C, Adetunji, J, Adeyeoluwa, T, Adha, R, Adhikary, R, Adnani, Q, Adzigbli, L, Afrashteh, F, Afzal, M, Afzal, S, Agbozo, F, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, B, Ahlstrom, A, Ahmad, A, Ahmad, F, Ahmad, M, Ahmad, S, Ahmed, A, Ahmed, H, Ahmed, S, Akinosoglou, K, Akkaif, M, Akrami, A, Akter, E, Al Awaidy, S, Al Hasan, S, Al Mosa, A, Al Ta'ani, O, Al Zaabi, O, Alahdab, F, Alajlani, M, Al-Ajlouni, Y, Alalalmeh, S, Al-Aly, Z, Alam, K, Alam, N, Alam, T, Alam, Z, Al-amer, R, Alanezi, F, Alanzi, T, Albakri, A, Aldhaleei, W, Aldridge, R, Alemohammad, S, Alemu, Y, Al-Gheethi, A, Al-Hanawi, M, Ali, A, Ali, I, Ali, M, Ali, R, Ali, S, Ali, V, Ali, W, Al-Ibraheem, A, Alicandro, G, Alif, S, Aljunid, S, Alla, F, Almazan, J, Al-Mekhlafi, H, Alqutaibi, A, Alrawashdeh, A, Alrousan, S, Al-Sabah, S, Alsabri, M, Altaany, Z, Al-Tammemi, A, Al-Tawfiq, J, Altirkawi, K, Aluh, D, Alvis-Guzman, N, Al-Wardat, M, Al-Worafi, Y, Aly, H, Alyahya, M, Alzoubi, K, Al-Zyoud, W, Amani, R, Ameyaw, E, Amin, T, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, M, Amu, H, Amugsi, D, Ancuceanu, R, Anderlini, D, Anderson, D, Andrade, P, Andrei, C, Andrei, T, Andrews, E, Anil, A, Anil, S, Anoushiravani, A, Antony, C, Antriyandarti, E, Anuoluwa, B, Anvari, S, Anyasodor, A, Appiah, F, Aquilano, M, Arab, J, Arabloo, J, Arafa, E, Arafat, M, Aravkin, A, Ardekani, A, Areda, D, Aregawi, B, Aremu, A, Ariffin, H, Arkew, M, Armani, K, Artamonov, A, Arumugam, A, Asghari-Jafarabadi, M, Ashbaugh, C, Astell-Burt, T, Athari, S, Atorkey, P, Atout, M, Aujayeb, A, Ausloos, M, Awad, H, Awotidebe, A, Ayatollahi, H, Ayuso-Mateos, J, Azadnajafabad, S, Azeez, F, Azevedo, R, Badar, M, Baghdadi, S, Bagheri, M, Bagheri, N, Bai, R, Baker, J, Bako, A, Balakrishnan, S, Balcha, W, Baltatu, O, Barchitta, M, Bardideh, E, Barker-Collo, S, Bärnighausen, T, Barqawi, H, Barteit, S, Basiru, A, Basso, J, Bastan, M, Basu, S, Bauckneht, M, Baune, B, Bayati, M, Bayileyegn, N, Behnoush, A, Behzadi, P, Beiranvand, M, Bello, O, Belo, L, Beloukas, A, Bemanalizadeh, M, Bensenor, I, Benzian, H, Beran, A, Berezvai, Z, Bernstein, R, Bettencourt, P, Beyene, K, Beyene, M, Bhagat, D, Bhagavathula, A, Bhala, N, Bhandari, D, Bharadwaj, R, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, V, Bhattacharjee, N, Bhatti, G, Bhatti, J, Bhatti, M, Bhuiyan, M, Bisignano, C, Biswas, B, Bjørge, T, Bodolica, V, Bodunrin, A, Bonakdar Hashemi, M, Bora Basara, B, Borhany, H, Bosoka, S, Botero Carvajal, A, Bouaoud, S, Boufous, S, Boxe, C, Boyko, E, Brady, O, Braithwaite, D, Brauer, M, Brazo-Sayavera, J, Brenner, H, Brown, C, Browne, A, Brugha, T, Bryazka, D, Bulamu, N, Buonsenso, D, Burkart, K, Burns, R, Busse, R, Bustanji, Y, Butt, Z, Caetano dos Santos, F, Çakmak Barsbay, M, Calina, D, Campos, L, Cao, S, Capodici, A, Cárdenas, R, Carreras, G, Carugno, A, Carvalho, M, Castaldelli-Maia, J, Castelpietra, G, Cattaruzza, M, Caye, A, Cegolon, L, Cembranel, F, Cenko, E, Cerin, E, Chadban, S, Chadwick, J, Chakraborty, C, Chakraborty, S, Chalek, J, Chan, J, Chandika, R, Chandy, S, Charan, J, Chaudhary, A, Chaurasia, A, Chen, A, Chen, H, Chen, M, Chen, S, Cherbuin, N, Chi, G, Chichagi, F, Chimed-Ochir, O, Chimoriya, R, Ching, P, Chirinos-Caceres, J, Chitheer, A, Cho, D, Cho, W, Choi, D, Chong, B, Chong, C, Chopra, H, Chu, D, Chung, E, Chutiyami, M, Clayton, J, Cogen, R, Cohen, A, Columbus, A, Comfort, H, Conde, J, Connolly, J, Cooper, E, Cortese, S, Cruz-Martins, N, da Silva, A, Dadras, O, Dai, X, Dai, Z, Dalton, B, Damiani, G, Dandona, L, Dandona, R, Das, J, Das, S, Dash, N, Davletov, K, De la Hoz, F, De Leo, D, Debopadhaya, S, Delgado-Enciso, I, Denova-Gutiérrez, E, Dervenis, N, Desai, H, Devanbu, V, Dewan, S, Dhama, K, Dhane, A, Dhingra, S, Dias da Silva, D, Diaz, D, Diaz, L, Diaz, M, Dima, A, Ding, D, Do, T, do Prado, C, Dodangeh, M, Doegah, P, Dohare, S, Dong, W, D'Oria, M, Doshi, R, Dowou, R, Dsouza, H, Dsouza, V, Dube, J, Dumith, S, Duncan, B, Duraes, A, Duraisamy, S, Durojaiye, O, Dushpanova, A, Dutta, S, Dzianach, P, Dziedzic, A, Eboreime, E, Ebrahimi, A, Ebrahimi Kalan, M, Edinur, H, Efendi, F, Eikemo, T, Eini, E, Ekundayo, T, El Arab, R, El Sayed, I, Elamin, O, Elemam, N, Elgohary, G, Elhadi, M, Elmeligy, O, Elmoselhi, A, Elshaer, M, Elsohaby, I, Eltahir, M, Emeto, T, Eshrati, B, Eslami, M, Esmaeili, Z, Fabin, N, Fagbamigbe, A, Fagbule, O, Falzone, L, Fareed, M, Farinha, C, Faris, M, Faro, A, Fasihi, K, Fatehizadeh, A, Fauk, N, Fazylov, T, Feigin, V, Fekadu, G, Feng, X, Fereshtehnejad, S, Ferrara, P, Ferreira, N, Firew, B, Fischer, F, Fitriana, I, Flavel, J, Flor, L, Folayan, M, Foley, K, Fonzo, M, Force, L, Foschi, M, Freitas, A, Fridayani, N, Fukutaki, K, Furtado, J, Fux, B, Gaal, P, Gadanya, M, Gallus, S, Ganesan, B, Ganiyani, M, Gautam, R, Gebi, T, Gebregergis, M, Gebrehiwot, M, Getacher, L, Getahun, G, Gething, P, Ghadimi, D, Ghadirian, F, Ghafarian, S, Ghailan, K, Ghasemi, M, Ghasempour Dabaghi, G, Ghazy, R, Ghoba, S, Gholami, E, Gholamrezanezhad, A, Gholizadeh, N, Ghorbani, M, Ghorbani Vajargah, P, Ghotbi, E, Gil, A, Gill, T, Girmay, A, Glasbey, J, Glushkova, E, Gnedovskaya, E, Göbölös, L, Goldust, M, Goleij, P, Golinelli, D, Gopalani, S, Goulart, A, Gouravani, M, Goyal, A, Grivna, M, Grosso, G, Guarducci, G, Gubari, M, Guicciardi, S, Guimarães, R, Gulati, S, Gulisashvili, D, Gunawardane, D, Guo, C, Gupta, A, Gupta, R, Gupta, S, Gupta, V, Haakenstad, A, Hadi, N, Haep, N, Hafiz, A, Haghmorad, D, Haile, D, Hajj Ali, A, Haj-Mirzaian, A, Halboub, E, Haller, S, Halwani, R, Hamagharib Abdullah, K, Hamdy, N, Hamoudi, R, Hanifi, N, Hankey, G, Haq, Z, Haque, M, Harapan, H, Hargono, A, Haro, J, Hasaballah, A, Hasan, S, Hasanian, M, Hasnain, M, Hassan, A, Haubold, J, Hay, S, Hebert, J, Hegazi, O, Heidari, M, Hemmati, M, Henson, C, Herrera-Serna, B, Herteliu, C, Heydari, M, Hezam, K, Hidayana, I, Hiraike, Y, Hoan, N, Holla, R, Hoogar, P, Horita, N, Hossain, M, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hu, C, Huang, J, Hultström, M, Hundie, T, Hunt, A, Hushmandi, K, Hussain, J, Hussain, M, Hussein, N, Huynh, H, Hwang, B, Ibitoye, S, Iftikhar, P, Ikiroma, A, Ikwegbue, P, Ilic, I, Ilic, M, Immurana, M, Isa, M, Islam, M, Islam, S, Ismail, F, Ismail, N, Isola, G, Iwagami, M, Iyamu, I, Jacob, L, Jacobsen, K, Jafarinia, M, Jahankhani, K, Jahanmehr, N, Jain, N, Jairoun, A, Jakhmola Mani, D, Jamil, S, Jamora, R, Jatau, A, Javadov, S, Javaheri, T, Jayaram, S, Jee, S, Jeganathan, J, Jiang, H, Jokar, M, Jonas, J, Joseph, N, Joshua, C, Jürisson, M, K, V, Kabir, A, Kabir, Z, Kadashetti, V, Kalankesh, L, Kalra, S, Kamath, A, Kamath, R, Kamireddy, A, Kanaan, M, Kanchan, T, Kanmiki, E, Kanmodi, K, Kansal, S, Karim, A, Karkhah, S, Kashoo, F, Kasraei, H, Kassel, M, Katikireddi, S, Kauppila, J, Kaur, H, Kayode, G, Kazemi, F, Kazemian, S, Kebede, F, Kendal, E, Kesse-Guyot, E, Khademvatan, S, Khajuria, H, Khalaji, A, Khalid, A, Khalid, N, Khalilian, A, Khamesipour, F, Khan, F, Khan, M, Khanmohammadi, S, Khatab, K, Khatatbeh, H, Khatatbeh, M, Khatib, M, Khayat Kashani, H, Kheirallah, K, Khokhar, M, Khormali, M, Khorrami, Z, Khosla, A, Khosravi, M, Khosrowjerdi, M, Khubchandani, J, Kifle, Z, Kim, G, Kim, J, Kim, M, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Knibbs, L, Knudsen, A, Kochhar, S, Kolahi, A, Kompani, F, Koren, G, Korzh, O, Krishan, K, Krishna, V, Krishnamoorthy, V, Kucuk Bicer, B, Kuddus, M, Kuitunen, I, Kujan, O, Kulimbet, M, Kulkarni, V, Kumar, G, Kumar, H, Kumar, N, Kumar, R, Kumar, V, Kundu, A, Kusuma, D, Kyei-Arthur, F, Kytö, V, Kyu, H, La Vecchia, C, Lacey, B, Ladan, M, Laflamme, L, Lahariya, C, Lai, D, Lalloo, R, Lallukka, T, Lám, J, Lan, Q, Lan, T, Landires, I, Lanfranchi, F, Langguth, B, Lansingh, V, Laplante-Lévesque, A, Larijani, B, Larsson, A, Lasrado, S, Lauriola, P, Lawlor, H, Le, H, Le, L, Le, N, Le, T, Leasher, J, Lee, D, Lee, M, Lee, P, Lee, S, Lee, Y, Leigh, J, Leong, E, Li, M, Libra, M, Ligade, V, Lim, L, Lim, S, Limenh, L, Lindholm, D, Lindstedt, P, Listl, S, Liu, G, Liu, S, Liu, X, Llanaj, E, López-Bueno, R, López-Gil, J, Loreche, A, Lotufo, P, Lozano, R, Lubinda, J, Lucchetti, G, Luo, L, Lusk, J, Lv, L, M Amin, H, Ma, Z, Maass, K, Machairas, N, Machoy, M, Madureira-Carvalho, Á, Magdy Abd El Razek, H, Maghazachi, A, Mahadeshwara Prasad, D, Mahalleh, M, Mahasha, P, Mahmoud, M, Mahmoudi, E, Mahmoudvand, G, Makama, M, Malakan Rad, E, Malhotra, K, Malik, A, Malta, D, Manla, Y, Mansour, A, Mansouri, M, Mansouri, P, Mansouri, V, Mansourian, M, Mansournia, M, Marasini, B, Marateb, H, Maravilla, J, Mardi, P, Marjani, A, Markazi Moghadam, H, Marrugo Arnedo, C, Martinez, G, Martinez-Piedra, R, Martins-Melo, F, Martorell, M, Marx, W, Marzo, R, Masoudi, S, Mathangasinghe, Y, Mathioudakis, A, Mathur, M, Mathur, N, Matozinhos, F, Mattumpuram, J, Maude, R, Maugeri, A, Mayeli, M, Mazidi, M, Mazzotti, A, Mcgrath, J, Mckee, M, Mckowen, A, Mcphail, M, Mcphail, S, Mehmood, A, Mehrabani-Zeinabad, K, Mehravar, S, Mekene Meto, T, Melese, E, Mendez-Lopez, M, Mendoza, W, Menezes, R, Mensah, G, Mensah, L, Mentis, A, Meo, S, Meretoja, A, Meretoja, T, Mersha, A, Mestrovic, T, Mettananda, K, Mettananda, S, Mhlanga, A, Mhlanga, L, Miazgowski, T, Michalek, I, Micheletti Gomide Nogueira de Sá, A, Miller, T, Minh, L, Mirahmadi, A, Mirijello, A, Mirrakhimov, E, Mirzaei, R, Mitchell, P, Mittal, C, Moberg, M, Moghadam Fard, A, Mohajelin, S, Mohamadkhani, A, Mohamed, A, Mohamed, J, Mohamed, M, Mohamed, N, Mohammad, A, Mohammadi, S, Mohammed, H, Mohammed, M, Mohammed, S, Mokdad, A, Molokhia, M, Momani, S, Momtazmanesh, S, Monasta, L, Mondello, S, Moni, M, Montazeri, F, Moodi Ghalibaf, A, Moradi, M, Moradi, Y, Moraga, P, Morawska, L, Moreira, R, Morovatdar, N, Morrison, S, Mosapour, A, Mosser, J, Mossialos, E, Motappa, R, Mougin, V, Mousavi, P, Mrejen, M, Mubarik, S, Mueller, U, Mulita, F, Munjal, K, Murillo-Zamora, E, Musallam, K, Musina, A, Mustafa, G, Myung, W, Nafei, A, Nagarajan, A, Naghavi, P, Naik, G, Nainu, F, Najdaghi, S, Nakhostin Ansari, N, Nangia, V, Narasimha Swamy, S, Nargus, S, Narimani Davani, D, Nascimento, B, Nascimento, G, Naser, A, Nashwan, A, Natto, Z, Nauman, J, Navaratna, S, Naveed, M, Nawsherwan, N, Nayak, B, Nayak, V, Negash, H, Negoi, I, Negoi, R, Nejadghaderi, S, Nejjari, C, Nematollahi, S, Netsere, H, Ng, M, Nguefack-Tsague, G, Ngunjiri, J, Nguyen, A, Nguyen, D, Nguyen, H, Nguyen, N, Nguyen, P, Nguyen, Q, Nguyen, V, Nguyen Tran Minh, D, Niazi, R, Nigatu, Y, Niknam, M, Nikoobar, A, Nikpoor, A, Nikravangolsefid, N, Noman, E, Nomura, S, Noor, S, Noroozi, N, Nouri, M, Nozari, M, Nri-Ezedi, C, Ntaios, G, Nunemo, M, Nurrika, D, Nutor, J, Nzoputam, C, Nzoputam, O, Oancea, B, Obamiro, K, Odetokun, I, Oduro, M, Ogundijo, O, Ogunfowokan, A, Ogunkoya, A, Oguntade, A, Oh, I, Ojo-Akosile, T, Okati-Aliabad, H, Okekunle, A, Okonji, O, Olagunju, A, Olatubi, M, Oliveira, G, Olusanya, B, Olusanya, J, Oluwafemi, Y, Omar, H, Omer, G, Ong, S, Onie, S, Onwujekwe, O, Opejin, A, Ordak, M, Orish, V, Ortiz, A, Ortiz-Prado, E, Osman, W, Ostojic, S, Ostroff, S, Osuagwu, U, Otoiu, A, Otstavnov, S, Ouyahia, A, Owolabi, M, Oyeyemi, O, Ozair, A, P A, M, Padron-Monedero, A, Padubidri, J, Pal, P, Palicz, T, Pan, F, Pan, H, Panda-Jonas, S, Pandey, A, Pando-Robles, V, Pangaribuan, H, Panos, G, Panos, L, Pantazopoulos, I, Pantea Stoian, A, Parikh, R, Park, E, Park, S, Parsons, N, Parthasarathi, A, Pasovic, M, Passera, R, Patel, J, Pathan, A, Patil, S, Patoulias, D, Pawar, S, Pazoki Toroudi, H, Pease, S, Peden, A, Pedersini, P, Pensato, U, Pepito, V, Peprah, P, Pereira, M, Perianayagam, A, Perico, N, Perna, S, Pesudovs, K, Petermann-Rocha, F, Pham, H, Philip, A, Phillips, M, Pigeolet, M, Piradov, M, Pisoni, E, Plotnikov, E, Poddighe, D, Polibin, R, Poluru, R, Ponkilainen, V, Popovic, D, Postma, M, Pour-Rashidi, A, Prabhu, D, Prada, S, Pradhan, J, Pradhan, P, Prashant, A, Prates, E, Priscilla, T, Purnobasuki, H, Purohit, B, Puvvula, J, Qasim, N, Qattea, I, Qazi, A, Qian, G, Rabiee Rad, M, Radhakrishnan, V, Raeisi Shahraki, H, Rafferty, Q, Raggi, A, Raggi, C, Raheem, N, Rahim, F, Rahim, M, Rahimibarghani, S, Rahman, M, Rahman, T, Rahmani, A, Rahmanian, M, Rahmanian, N, Rahmati, R, Rahmawaty, S, Raimondo, D, Raja, A, Rajput, P, Ramadan, M, Ramasamy, S, Ramazanu, S, Ramteke, P, Rana, K, Rana, R, Ranabhat, C, Rane, A, Rao, C, Rao, M, Rasella, D, Rashedi, V, Rashid, A, Rasouli-Saravani, A, Rastogi, P, Rasul, A, Rathish, D, Rathnaiah Babu, G, Rauniyar, S, Ravangard, R, Rawaf, D, Rawaf, S, Raza, R, Redwan, E, Reifels, L, Reitsma, M, Remuzzi, G, Rengasamy, K, Reshmi, B, Resnikoff, S, Restaino, S, Reyes, L, Rezaei, N, Rezaei, Z, Rezaeian, M, Rhee, T, Rickard, J, Robalik, T, Robinson-Oden, H, Rocha, H, Rodrigues, M, Rodriguez, J, Roever, L, Romadlon, D, Ronfani, L, Rony, M, Roshandel, G, Rotimi, K, Rout, H, Roy, B, Rubagotti, E, Ruela, G, Rumisha, S, Runghien, T, Russo, M, Saad, A, Saber, K, Saber-Ayad, M, Sabet, C, Sabour, S, Sachdev, P, Saddler, A, Sadee, B, Sadeghi, M, Saeb, M, Saeed, U, Safi, S, Sagar, R, Saghafi, A, Sagoe, D, Sahebkar, A, Sahoo, P, Sajid, M, Salam, N, Salamati, P, Salami, A, Saleh, M, Salehi, L, Salem, M, Salemcity, A, Salimi, S, Samadi Kafil, H, Samargandy, S, Samodra, Y, Samy, A, Sanabria, J, Sanna, F, Santric-Milicevic, M, Sao Jose, B, Saraswathy, S, Saravanan, A, Sarmiento-Suárez, R, Sarode, G, Sarode, S, Sartorius, B, Satpathy, M, Sayeed, A, Scarmeas, N, Schaarschmidt, B, Schinckus, C, Schuermans, A, Schumacher, A, Schutte, A, Schwebel, D, Schwendicke, F, Selvaraj, S, Semreen, M, Senapati, S, Sengupta, P, Senthilkumaran, S, Serban, D, Sethi, Y, Seylani, A, Shafie, M, Shah, P, Shahbandi, A, Shahid, S, Shahid, W, Shahsavari, H, 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- Published
- 2024
39. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
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- Published
- 2024
40. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
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Volovat, Simona Ruxandra, Vos, Theo, Vujcic, Isidora S, Waheed, Yasir, Wang, Cong, Wang, Fang, Wang, Shu, Wang, Yanzhong, Wang, Yuan-Pang, Wanjau, Mary Njeri, Waqas, Muhammad, Ward, Paul, Waris, Abdul, Wassie, Emebet Gashaw, Weerakoon, Kosala Gayan, Weintraub, Robert G, Weiss, Daniel J, Weiss, Eli J, Weldetinsaa, Haftom Legese Legese, Wells, Katherine M, Wen, Yi Feng, Wiangkham, Taweewat, Wickramasinghe, Nuwan Darshana, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wong, Yen Jun, Wongsin, Utoomporn, Wozniak, Sarah, Wu, Chenkai, Wu, Dongze, Wu, Felicia, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xu, Suowen, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadav, Mukesh Kumar, Yaghoubi, Sajad, Yamagishi, Kazumasa, Yang, Lin, Yano, Yuichiro, Yaribeygi, Habib, Yasufuku, Yuichi, Ye, Pengpeng, Yesodharan, Renjulal, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yiğit, Arzu, Yigzaw, Zeamanuel Anteneh, Yin, Dehui, Yip, Paul, Yismaw, Malede Berihun, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Zadey, Siddhesh, Zadnik, Vesna, Zakham, Fathiah, Zaki, Nazar, Zakzuk, Josefina, Zamagni, Giulia, Zaman, Sojib Bin, Zandieh, Ghazal G Z, Zanghì, Aurora, Zar, Heather J, Zare, Iman, Zarimeidani, Fatemeh, Zastrozhin, Mikhail Sergeevich, Zeng, Youjie, Zhai, Chunxia, Zhang, Anthony Lin, Zhang, Haijun, Zhang, Liqun, Zhang, Meixin, Zhang, Yunquan, Zhang, Zhenyu, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhao, Jeff T, Zhao, Xiu-Ju George, Zhao, Yang, Zhao, Yong, Zhong, Chenwen, Zhou, Jingjing, Zhou, Juexiao, Zhou, Shangcheng, Zhu, Bin, Zhu, Lei, Zhu, Zhaohua, Ziaeian, Boback, Ziafati, Makan, Zielińska, Magdalena, Zimsen, Stephanie R M, Zoghi, Ghazal, Zoller, Thomas, Zumla, Alimuddin, Zyoud, Sa'ed H, Zyoud, Samer H, Murray, Christopher J L, and Gakidou, Emmanuela
- Published
- 2024
41. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
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Benjamin A, Starodubova, Antonina V, Stein, Caroline, Stein, Dan J, Steiner, Caitlyn, Steiner, Timothy J, Steinmetz, Jaimie D, Steiropoulos, Paschalis, Stockfelt, Leo, Stokes, Mark A, Subedi, Narayan Subedi, Subramaniyan, Vetriselvan, Suemoto, Claudia Kimie, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sundström, Johan, Swain, Chandan Kumar, Szarpak, Lukasz, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabche, Celine, Tabish, Mohammad, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taherkhani, Amir, Taiba, Jabeen, Talaat, Iman M, Talukder, Ashis, Tampa, Mircea, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tandukar, Sarmila, Tang, Haosu, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Teimoori, Mojtaba, Temsah, Mohamad-Hani, Teramoto, Masayuki, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Thapar, Rekha, Thayakaran, Rasiah, Thirunavukkarasu, 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Yazdanpanah, Mohammad Hosein, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesuf, Subah Abderehim, Yezli, Saber, Yiğit, Arzu, Yiğit, Vahit, Yigzaw, Zeamanuel Anteneh, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Younis, Mustafa Z, Yu, Chuanhua, Yu, Yong, Yusuf, Hadiza, Zahid, Mondal Hasan, Zakham, Fathiah, Zaki, Leila, Zaki, Nazar, Zaman, Burhan Abdullah, Zamora, Nelson, Zand, Ramin, Zandieh, Ghazal G Z, Zar, Heather J, Zarrintan, Armin, Zastrozhin, Mikhail Sergeevich, Zhang, Haijun, Zhang, Ning, Zhang, Yunquan, Zhao, Hanqing, Zhong, Chenwen, Zhong, Panliang, Zhou, Juexiao, Zhu, Zhaohua, Ziafati, Makan, Zielińska, Magdalena, Zimsen, Stephanie R M, Zoladl, Mohammad, Zumla, Alimuddin, Zyoud, Samer H, Vos, Theo, and Murray, Christopher J L
- Published
- 2024
42. Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
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V Bhattacharjee, N, E Schumacher, A, Aali, A, Habtegiorgis Abate, Y, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abd-Elsalam, S, Abdollahi, M, Abdollahifar, M, Abdoun, M, Abdullahi, A, Abebe, M, Shawel Abebe, S, Abiodun, O, Abolhassani, H, Abolmaali, M, Abouzid, M, Beressa Aboye, G, Guimarães Abreu, L, Aberhe Abrha, W, M Abrigo, M, Abtahi, D, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Me Abu-Rmeileh, N, Girum Girum Adal, T, Molla Adane, M, Atanda Adeagbo Adeagbo, O, Adesoji Adedoyin, R, Adekanmbi, V, Aden, B, Victor Adepoju, A, O Adetokunboh, O, Bunmi Adetunji, J, Adedayo Adeyinka, D, Israel Adeyomoye, O, Estiningtyas Sakilah Adnani, Q, Adra, S, Felix Afolabi, R, Afyouni, S, Sohail Afzal, M, Afzal, S, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Opoku Ahinkorah, B, J Ahlstrom, A, Ahmad, A, Ahmad, D, Ahmad, F, M Ahmad, M, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, H, A Ahmed, L, Saleh Ahmed, M, Anees Ahmed, S, Ajami, M, Aji, B, Taddesse Akalu, G, 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Munkhtuya Tumurkhuu, Stefanos Tyrovolas, Sayed Mohammad Nazim Uddin, Aniefiok John Udoakang, Arit Udoh, Atta Ullah, Saeed Ullah, Sana Ullah, Srikanth Umakanthan, Chukwuma David Umeokonkwo, Brigid Unim, Bhaskaran Unnikrishnan, Era Upadhyay, Jibrin Sammani Usman, Marco Vacante, Seyed Mohammad Vahabi, Asokan Govindaraj Vaithinathan, Rohollah Valizadeh, Jef Van den Eynde, Elena Varavikova, Orsolya Varga, Priya Vart, Shoban Babu Varthya, Tommi Juhani Vasankari, Balachandar Vellingiri, Deneshkumar Venugopal, Nicholas Alexander Verghese, Madhur Verma, Massimiliano Veroux, Georgios-Ioannis Verras, Dominique Vervoort, Jorge Hugo Villafañe, Manish Vinayak, Francesco S Violante, Mukesh Vishwakarma, Sergey Konstantinovitch Vladimirov, Vasily Vlassov, Bay Vo, Simona Ruxandra Volovat, Theo Vos, Isidora S Vujcic, Hatem A Wafa, Yasir Waheed, Elias Bekele Wakwoya, Cong Wang, Denny Wang, Fang Wang, Shu Wang, Yanzhong Wang, Yuan-Pang Wang, Paul Ward, Emebet Gashaw Wassie, Stefanie Watson, Marcia R Weaver, Kosala Gayan Weerakoon, Daniel J Weiss, Katherine M Wells, Yi Feng Wen, Ronny Westerman, Taweewat Wiangkham, Dakshitha Praneeth Wickramasinghe, Nuwan Darshana Wickramasinghe, Peter Willeit, Yohannes Addisu Wondimagegene, Felicia Wu, Juan Xia, Hong Xiao, Gelin Xu, Suowen Xu, Xiaoyue Xu, Ali Yadollahpour, Shirin Yaghoobpoor, Tina Yaghoobpour, Sajad Yaghoubi, Zwanden Sule Yahaya, Danting Yang, Lin Yang, Yuichiro Yano, Habib Yaribeygi, Pengpeng Ye, Renjulal Yesodharan, Subah Abderehim Yesuf, Saber Yezli, Amanuel Yigezu, Paul Yip, Dong Keon Yon, Naohiro Yonemoto, Yuyi You, Mustafa Z Younis, Zabihollah Yousefi, Chuanhua Yu, Yong Yu, Chun-Wei Yuan, Nima Zafari, Fathiah Zakham, Nazar Zaki, Giulia Zamagni, Milad Zandi, Ghazal G Z Zandieh, Moein Zangiabadian, Mikhail Sergeevich Zastrozhin, Haijun Zhang, Meixin Zhang, Yunquan Zhang, Chenwen Zhong, Juexiao Zhou, Bin Zhu, Lei Zhu, Magdalena Zielińska, Zhiyong Zou, Samer H Zyoud, Christopher J L Murray, Amanda E Smith, and Stein Emil Vollset
- Abstract
Background: Accurate assessments of current and future fertility-including overall trends and changing population age structures across countries and regions-are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 based on a reference scenario and key policy-dependent alternative scenarios. Methods: To estimate fertility indicators from 1950 to 2021, mixed-effects regression models and spatiotemporal Gaussian process regression were used to synthesise data from 8709 country-years of vital and sample registrations, 1455 surveys and censuses, and 150 other sources, and to generate age-specific fertility rates (ASFRs) for 5-year age groups from age 10 years to 54 years. ASFRs were summed across age groups to produce estimates of total fertility rate (TFR). Livebirths were calculated by multiplying ASFR and age-specific female population, then summing across ages 10-54 years. To forecast future fertility up to 2100, our Institute for Health Metrics and Evaluation (IHME) forecasting model was based on projections of completed cohort fertility at age 50 years (CCF50; the average number of children born over time to females from a specified birth cohort), which yields more stable and accurate measures of fertility than directly modelling TFR. CCF50 was modelled using an ensemble approach in which three sub-models (with two, three, and four covariates variously consisting of female educational attainment, contraceptive met need, population density in
- Published
- 2024
43. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
- Author
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Yin, D, Yip, P, Yonemoto, N, You, Y, Younis, MZ, Yu, C, Yu, EA, Yu, Y, Yuan, C-W, Yusuf, H, Zafar, U, Zafari, N, Zahid, MH, Zakham, F, Zaki, N, Zerfu, TA, Zhang, H, Zhang, J, Zhang, L, Zhang, Y, Zhang, Z, Zhao, X-JG, Zhao, Y, Zhao, Z, Zhong, C, Zhou, B, Zhou, J, Zhou, S, Zhu, B, Zhumagaliuly, A, Zielińska, M, Zoghi, G, Zumla, A, Zyoud, SH, Smith, AE, and Murray, CJL
- Published
- 2024
44. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
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Ferrari, AJ, Santomauro, DF, Aali, A, Abate, YH, Abbafati, C, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdollahi, A, Abdullahi, A, Abegaz, KH, Abeldaño Zuñiga, RA, Aboagye, RG, Abolhassani, H, Abreu, LG, Abualruz, H, Abu-Gharbieh, E, Abu-Rmeileh, NME, Ackerman, IN, Addo, IY, Addolorato, G, Adebiyi, AO, Adepoju, AV, Adewuyi, HO, Afyouni, S, Afzal, S, Agodi, A, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, S, Ahmed, A, Ahmed, LA, Ahmed, MB, Ajami, M, Akinosoglou, K, Akkaif, MA, Al Hasan, SM, Alalalmeh, SO, Al-Aly, Z, Albashtawy, M, Aldridge, RW, Alemu, MD, Alemu, YM, Alene, KA, Al-Gheethi, AAS, Alharrasi, M, Alhassan, RK, Ali, MU, Ali, R, Ali, SSS, Alif, SM, Aljunid, SM, Al-Marwani, S, Almazan, JU, Alomari, MA, Al-Omari, B, Altaany, Z, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Alwafi, H, Al-Wardat, MS, Al-Worafi, YM, Aly, S, Alzoubi, KH, Amare, AT, Amegbor, PM, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, 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D, Eikemo, TA, Eini, E, Ekholuenetale, M, Ekundayo, TC, El Sayed, I, El Tantawi, M, Elbarazi, I, Elemam, NM, ElGohary, GMT, Elhadi, M, Elmeligy, OAA, ELNahas, G, Elshaer, M, Elsohaby, I, Engelbert Bain, L, Erkhembayar, R, Eshrati, B, Estep, K, Fabin, N, Fagbamigbe, AF, Falzone, L, Fareed, M, Farinha, CSES, Faris, MEM, Faro, A, Farrokhi, P, Fatehizadeh, A, Fauk, NK, Feigin, VL, Feng, X, Fereshtehnejad, S-M, Feroze, AH, Ferreira, N, Ferreira, PH, Fischer, F, Flavel, J, Flood, D, Flor, LS, Foigt, NA, Folayan, MO, Force, LM, Fortuna, D, Foschi, M, Franklin, RC, Freitas, A, Fukumoto, T, Furtado, JM, Gaal, PA, Gadanya, MA, Gaidhane, AM, Gaihre, S, Galali, Y, Ganbat, M, Gandhi, AP, Ganesan, B, Ganie, MA, Ganiyani, MA, Gardner, WM, Gebi, TG, Gebregergis, MW, Gebrehiwot, M, Gebremariam, TBB, Gebremeskel, TG, Gela, YY, Georgescu, SR, Getachew Obsa, A, Gething, PW, Getie, M, Ghadiri, K, Ghadirian, F, Ghailan, KY, Ghajar, A, Ghasemi, M, Ghasempour Dabaghi, G, Ghasemzadeh, A, Ghazy, RM, 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H, Ma, ZF, Machairas, N, Madureira-Carvalho, ÁM, Magaña Gómez, JA, Maghazachi, AA, Maharjan, P, Mahasha, PW, Maheri, M, Mahjoub, S, Mahmoud, MA, Mahmoudi, E, Majeed, A, Makris, KC, Malakan Rad, E, Malhotra, K, Malik, AA, Malik, I, Malta, DC, Manla, Y, Mansour, A, Mansouri, P, Mansournia, MA, Mantilla Herrera, AM, Mantovani, LG, Manu, E, Marateb, HR, Mardi, P, Martinez, G, Martinez-Piedra, R, Martini, D, Martins-Melo, FR, Martorell, M, Marx, W, Maryam, S, Marzo, RR, Mathangasinghe, Y, Mathieson, S, Mathioudakis, AG, Mattumpuram, J, Maugeri, A, Mayeli, M, Mazidi, M, Mazzotti, A, McGrath, JJ, McKee, M, McKowen, ALW, McPhail, MA, Mehrabani-Zeinabad, K, Mehrabi Nasab, E, Mekene Meto, T, Mendoza, W, Menezes, RG, Mensah, GA, Mentis, A-FA, Meo, SA, Meresa, HA, Meretoja, A, Meretoja, TJ, Mersha, AM, Mestrovic, T, Mettananda, KCD, Mettananda, S, Michalek, IM, Miller, PA, Miller, TR, Mills, EJ, Minh, LHN, Mirijello, A, Mirrakhimov, EM, Mirutse, MK, Mirza-Aghazadeh-Attari, M, Mirzaei, M, Mirzaei, R, Misganaw, A, Mishra, AK, Mitchell, PB, Mittal, C, Moazen, B, Moberg, ME, Mohamed, J, Mohamed, MFH, Mohamed, NS, Mohammadi, E, Mohammadi, S, Mohammed, H, Mohammed, S, Mohr, RM, Mokdad, AH, Molinaro, S, Momtazmanesh, S, Monasta, L, Mondello, S, Moodi Ghalibaf, A, Moradi, M, Moradi, Y, Moradi-Lakeh, M, Moraga, P, Morawska, L, Moreira, RS, Morovatdar, N, Morrison, SD, Morze, J, Mosapour, A, Mosser, JF, Mossialos, E, Motappa, R, Mougin, V, Mouodi, S, Mrejen, M, Msherghi, A, Mubarik, S, Mueller, UO, Mulita, F, Munjal, K, Murillo-Zamora, E, Murlimanju, BV, Mustafa, G, Muthu, S, Muzaffar, M, Myung, W, Nagarajan, AJ, Naghavi, P, Naik, GR, Nainu, F, Nair, S, Najmuldeen, HHR, Nangia, V, Naqvi, AA, Narayana, AI, Nargus, S, Nascimento, GG, Nashwan, AJ, Nasrollahizadeh, A, Natto, ZS, Nayak, BP, Nayak, VC, Nduaguba, SO, Negash, H, Negoi, I, Negoi, RI, Nejadghaderi, SA, Nesbit, OD, Netsere, HB, Ng, M, Nguefack-Tsague, G, Ngunjiri, JW, Nguyen, DH, Nguyen, HQ, Niazi, RK, Nikolouzakis, TK, Nikoobar, A, Nikoomanesh, F, Nikpoor, AR, Nnaji, CA, Nnyanzi, LA, Noman, EA, Nomura, S, Norrving, B, Nri-Ezedi, CA, Ntaios, G, Ntsekhe, M, Nurrika, D, Nzoputam, CI, Nzoputam, OJ, Oancea, B, Odetokun, IA, O'Donnell, MJ, Oguntade, AS, Oguta, JO, Okati-Aliabad, H, Okeke, SR, Okekunle, AP, Okonji, OC, Olagunju, AT, Olasupo, OO, Olatubi, MI, Oliveira, GMM, Olufadewa, II, Olusanya, BO, Olusanya, JO, Omar, HA, Omer, GL, Omonisi, AEE, Onie, S, Onwujekwe, OE, Ordak, M, Orish, VN, Ortega-Altamirano, DV, Ortiz, A, Ortiz-Brizuela, E, Osman, WMS, Ostroff, SM, Osuagwu, UL, Otoiu, A, Otstavnov, N, Otstavnov, SS, Ouyahia, A, Ouyang, G, Owolabi, MO, P A, MP, Padron-Monedero, A, Padubidri, JR, Palicz, T, Palladino, C, Pan, F, Pandi-Perumal, SR, Pangaribuan, HU, Panos, GD, Panos, LD, Pantea Stoian, AM, Pardhan, S, Parikh, RR, Pashaei, A, Pasovic, M, Passera, R, Patel, J, Patel, SK, Patil, S, Patoulias, D, Patthipati, VS, Pawar, S, Pazoki Toroudi, H, Pease, SA, Peden, AE, Pedersini, P, Peng, M, Pensato, U, Pepito, VCF, Peprah, EK, Peprah, P, Perdigão, J, Pereira, MO, Perianayagam, A, Perico, N, Pesudovs, K, Petermann-Rocha, FE, Petri, WA, Pham, HT, Philip, AK, Phillips, MR, Pigeolet, M, Pigott, DM, Pillay, JD, Piracha, ZZ, Pirouzpanah, S, Plass, D, Plotnikov, E, Poddighe, D, Polinder, S, Postma, MJ, Pourtaheri, N, Prada, SI, Pradhan, PMS, Prakash, V, Prasad, M, Prates, EJS, Priscilla, T, Pritchett, N, Puri, P, Puvvula, J, Qasim, NH, Qattea, I, Qazi, AS, Qian, G, Rabiee Rad, M, Radhakrishnan, RA, Radhakrishnan, V, Raeisi Shahraki, H, Rafferty, Q, Raggi, A, Raghav, PR, Rahim, MJ, Rahman, MM, Rahman, MHU, Rahman, M, Rahman, MA, Rahmani, S, Rahmanian, M, Rahmawaty, S, Rajaa, S, Ramadan, MM, Ramasamy, SK, Ramasubramani, P, Ramazanu, S, Rana, K, Ranabhat, CL, Rancic, N, Rane, A, Rao, CR, Rao, K, Rao, M, Rao, SJ, Rashidi, M-M, Rathnaiah Babu, G, Rauniyar, SK, Rawaf, DL, Rawaf, S, Razo, C, Reddy, MMRK, Redwan, EMM, Reifels, L, Reiner Jr, RC, Remuzzi, G, Renzaho, AMN, Reshmi, B, Reyes, LF, Rezaei, N, Rezaei Hachesu, P, Rezaeian, M, Rickard, J, Rodrigues, CF, Rodriguez, JAB, Roever, L, Ronfani, L, Roshandel, G, Rotimi, K, Rout, HS, Roy, B, Roy, N, Roy, P, Rubagotti, E, S N, C, Saad, AMA, Saber-Ayad, MM, Sabour, S, Sacco, S, Sachdev, PS, Saddik, B, Saddler, A, Sadee, BA, Sadeghi, E, Sadeghi, M, Saeb, MR, Saeed, U, Safi, SZ, Sagar, R, Sagoe, D, Saif, Z, Sajid, MR, Sakshaug, JW, Salam, N, Salami, AA, Salaroli, LB, Saleh, MA, Salem, MR, Salem, MZY, Sallam, M, Samadzadeh, S, Samargandy, S, Samodra, YL, Samy, AM, Sanabria, J, Sanna, F, Santos, IS, Santric-Milicevic, MM, Sarasmita, MA, Sarikhani, Y, Sarmiento-Suárez, R, Sarode, GS, Sarode, SC, Sarveazad, A, Sathian, B, Sathyanarayan, A, Satpathy, M, Sawhney, M, Scarmeas, N, Schaarschmidt, BM, Schmidt, MI, Schneider, IJC, Schumacher, AE, Schwebel, DC, Schwendicke, F, Sedighi, M, Senapati, S, Senthilkumaran, S, Sepanlou, SG, Sethi, Y, Setoguchi, S, Seylani, A, Shadid, J, Shafie, M, Shah, H, Shah, NS, Shah, PA, Shahbandi, A, Shahid, S, Shahid, W, Shahwan, MJ, Shaikh, MA, Shakeri, A, Shalash, AS, Sham, S, Shamim, MA, Shamshirgaran, MA, Shamsi, MA, Shanawaz, M, Shankar, A, Shannawaz, M, Sharath, M, Sharifan, A, Sharifi-Rad, J, Sharma, M, Sharma, R, Sharma, S, Sharma, U, Sharma, V, Shastry, RP, Shavandi, A, Shayan, AM, Shayan, M, Shehabeldine, AME, Shetty, PH, Shibuya, K, Shifa, JE, Shiferaw, D, Shiferaw, WS, Shigematsu, M, Shiri, R, Shitaye, NA, Shittu, A, Shivakumar, KM, Shivarov, V, Shokati Eshkiki, Z, Shool, S, Shrestha, S, Shuval, K, Sibhat, MM, Siddig, EE, Sigfusdottir, ID, Silva, DAS, Silva, JP, Silva, LMLR, Silva, S, Simpson, CR, Singal, A, Singh, A, Singh, BB, Singh, H, Singh, JA, Singh, M, Singh, P, Skou, ST, Sleet, DA, Slepak, ELN, Solanki, R, Soliman, SSM, Song, S, Song, Y, Sorensen, RJD, Soriano, JB, Soyiri, IN, Spartalis, M, Sreeramareddy, CT, Stark, BA, Starodubova, AV, Stein, C, Stein, DJ, Steiner, C, Steiner, TJ, Steinmetz, JD, Steiropoulos, P, Stockfelt, L, Stokes, MA, Subedi, NS, Subramaniyan, V, Suemoto, CK, Suleman, M, Suliankatchi Abdulkader, R, Sultana, A, Sundström, J, Swain, CK, Szarpak, L, Tabaee Damavandi, P, Tabarés-Seisdedos, R, Tabatabaei Malazy, O, Tabatabaeizadeh, S-A, Tabatabai, S, Tabche, C, Tabish, M, Tadakamadla, SK, Taheri Abkenar, Y, Taheri Soodejani, M, Taherkhani, A, Taiba, J, Talaat, IM, Talukder, A, Tampa, M, Tamuzi, JL, Tan, K-K, Tandukar, S, Tang, H, Tavakoli Oliaee, R, Tavangar, SM, Teimoori, M, Temsah, M-H, Teramoto, M, Thangaraju, P, Thankappan, KR, Thapar, R, Thayakaran, R, Thirunavukkarasu, S, Thomas, N, Thomas, NK, Thum, CCC, Tichopad, A, Ticoalu, JHV, Tillawi, T, Tiruye, TY, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Torre, AE, Touvier, M, Tovani-Palone, MR, Tran, JT, Tran, MTN, Tran, NM, Tran, N-H, Trico, D, Tromans, SJ, Truyen, TTTT, Tsatsakis, A, Tsegay, GM, Tsermpini, EE, Tumurkhuu, M, Tyrovolas, S, Udoh, A, Umair, M, Umakanthan, S, Umar, TP, Undurraga, EA, Unim, B, Unnikrishnan, B, Unsworth, CA, Upadhyay, E, Urso, D, Usman, JS, Vahabi, SM, Vaithinathan, AG, Van den Eynde, J, Varga, O, Varma, RP, Vart, P, Vasankari, TJ, Vasic, M, Vaziri, S, Vellingiri, B, Venketasubramanian, N, Veroux, M, Verras, G-I, Vervoort, D, Villafañe, JH, Violante, FS, Vlassov, V, Vollset, SE, Volovat, SR, Vongpradith, A, Waheed, Y, Wang, C, Wang, F, Wang, N, Wang, S, Wang, Y, Wang, Y-P, Ward, P, Wassie, EG, Weaver, MR, Weerakoon, KG, Weintraub, RG, Weiss, DJ, Weldemariam, AH, Wells, KM, Wen, YF, Whisnant, JL, Whiteford, HA, Wiangkham, T, Wickramasinghe, DP, Wickramasinghe, ND, Wilandika, A, Wilkerson, C, Willeit, P, Wimo, A, Woldegebreal, DH, Wolf, AW, Wong, YJ, Woolf, AD, Wu, C, Wu, F, Wu, X, Wu, Z, Wulf Hanson, S, Xia, Y, Xiao, H, Xu, X, Xu, YY, Yadav, L, Yadollahpour, A, Yaghoubi, S, Yamagishi, K, Yang, L, Yano, Y, Yao, Y, Yaribeygi, H, Yazdanpanah, MH, Ye, P, Yehualashet, SS, Yesuf, SA, Yezli, S, Yiğit, A, Yiğit, V, Yigzaw, ZA, Yismaw, Y, Yon, DK, Yonemoto, N, Younis, MZ, Yu, C, Yu, Y, Yusuf, H, Zahid, MH, Zakham, F, Zaki, L, Zaki, N, Zaman, BA, Zamora, N, Zand, R, Zandieh, GGZ, Zar, HJ, Zarrintan, A, Zastrozhin, MS, Zhang, H, Zhang, N, Zhang, Y, Zhao, H, Zhong, C, Zhong, P, Zhou, J, Zhu, Z, Ziafati, M, Zielińska, M, Zimsen, SRM, Zoladl, M, Zumla, A, Zyoud, SH, Vos, T, and Murray, CJL
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- 2024
45. Effect of periodontal therapy on COPD outcomes: a systematic review
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Ioulianos Apessos, Athanasios Voulgaris, Michalis Agrafiotis, Dimitrios Andreadis, and Paschalis Steiropoulos
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Chronic obstructive pulmonary disease ,COPD exacerbation ,Periodontal therapy ,Oral health ,Systematic review ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Latest evidence suggests that periodontitis is prevalent among patients with chronic obstructive pulmonary disease (COPD), while recent studies have also reported a potential benefit of periodontal treatment on several COPD outcomes. This systematic review aims to determine the impact of periodontal treatment on exacerbation rate, lung function and quality of life of COPD patients. Methods A systematic search of electronic databases of PubMed, Scopus, Virtual Health Library, ScienceDirect, Wiley Online Library, Web of Science, ProQuest Dissertation and Theses Global and Google Scholar was conducted. Search restricted to studies involving human subjects which were published from January 2000 to March 2020 in English language. Distiller Systematic Review software was used for data management. Risk of bias was assessed using Risk of Bias 2 (RoB2) and Risk of Bias for non-randomized studies of intervention (ROBINS-I) tools. Overall quality of evidence was judged based on Grading of Recommendations Assessment, Development and Evaluation working group methodology. Results Out of 1442 articles retrieved, 7 full text articles were included in the review. Limited evidence suggests that periodontal treatment in patients with COPD and periodontitis is associated with reduced exacerbation frequency and a slower lung function decline rate, while its effects on quality of life remain unclear. In addition, periodontal treatment in COPD is associated with lower hospitalization rates and reduced all-cause mortality. Significant methodological differences were noted amongst included studies, while very low-to-moderate overall quality of evidence was demonstrated. Conclusions Although it is reasonable to advise COPD patients not to neglect their dental health, further studies are warranted to determine the role of periodontal therapy on COPD clinical outcomes. Trial Registration: PROSPERO 2020 (CRD42020158481). https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020158481
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- 2021
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46. Non-Small-Cell Lung Cancer Immunotherapy and Sleep Characteristics: The Crossroad for Optimal Survival
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Paul Zarogoulidis, Dimitrios Petridis, Christoforos Kosmidis, Konstantinos Sapalidis, Lila Nena, Dimitris Matthaios, Vasilis Papadopoulos, Eleni Isidora Perdikouri, Konstantinos Porpodis, Paschalis Kakavelas, and Paschalis Steiropoulos
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non-small-cell lung cancer ,immunotherapy ,sleep medicine ,polysomnography ,cancer ,insomnia ,Medicine - Abstract
Introduction: Non-small-cell lung cancer is still diagnosed at an inoperable stage and systematic treatment is the only option. Immunotherapy is currently considered to be the tip of the arrow as the first-line treatment for patients with a programmed death-ligand 1 ≥ 50. Sleep is known to be an essential part of our everyday life. Patients and Methods: We investigated, upon diagnosis and after nine months, 49 non-small-cell lung cancer patients undergoing immunotherapy treatment with nivolumab and pemprolisumab. A polysomnographic examination was conducted. Moreover, the patients completed the Epworth Sleepiness Scale (ESS), the Pittsburgh Sleep Quality Index (PSQI), the Fatigue Severity Scale (FSS) and the Medical Research Council (MRC) dyspnea scale. Results: Tukey mean-difference plots, summary statistics, and the results of paired t-test of five questionnaire responses in accordance with the PD-L1 test across groups were examined. The results indicated that, upon diagnosis, patients had sleep disturbances which were not associated with brain metastases or their PD-L1 expression status. However, the PD-L1 status and disease control were strongly associated, since a PD-L1 ≥80 improved the disease status within the first 4 months. All data from the sleep questionnaires and polysomnography reports indicated that the majority of patients with a partial response and complete response had their initial sleep disturbances improved. There was no connection between nivolumab or pembrolisumab and sleep disturbances. Conclusion: Upon diagnosis, lung cancer patients have sleep disorders such as anxiety, early morning wakening, late sleep onset, prolonged nocturnal waking periods, daytime sleepiness, and unrefreshing sleep. However, these symptoms tend to improve very quickly for patients with a PD-L1 expression ≥80, because disease status improves also very quickly within the first 4 months of treatment.
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- 2023
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47. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)
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Steiropoulos, P., Verbraecken, J., Petiet, E., Trakada, G., Montserrat, J.M., Fietze, I., Penzel, T., Ondrej, L., Rodenstein, D., Masa, J.F., Bouloukaki, I., Schiza, S., Kent, B., McNicholas, W.T., Ryan, S., Riha, R.L., Kvamme, J.A., Hein, H., Schulz, R., Grote, L., Hedner, J., Zou, D., Pépin, J.L., Levy, P., Bailly, S., Lavie, L., Lavie, P., Basoglu, O.K., Tasbakan, M.S., Varoneckas, G., Joppa, P., Tkacova, R., Staats, R., Barbé, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Bonsignore, M.R., Marrone, O., Petitjean, M., Roisman, G., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Pataka, A., Anttalainen, U., Saaresranta, T., Plywaczewski, R., Sliwinski, P., Bielicki, P., Gunduz, Canan, Basoglu, Ozen K., Kvamme, John Arthur, Verbraecken, Johan, Anttalainen, Ulla, Marrone, Oreste, Steiropoulos, Paschalis, Roisman, Gabriel, Joppa, Pavol, Hein, Holger, Trakada, Georgia, Hedner, Jan, and Grote, Ludger
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- 2020
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48. Beliefs and preferences regarding biological treatments for severe asthma
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Ardelean, Carmen, Badellino, Hector, Blua, Ariel, Castillo, Antonio, Carpagnano Giovanna, E., Chong-Neto Herberto, J., Colodenco, F. Daniel, Md Colombaro, Dario, Correia-De-Sousa, Jaime, Di Marco, Fabiano, Dobashi, Kunio, Garcia, Rocio, Gomez, René Maximiliano, Gopko, Olecsandr, Guidos, Guillermo, Hajduk, Martina, Hermanowicz-Salamon, Joanna, Heffler, Enrico, Karadag, Bulent, Kalyoncu, Ali F., Keren, Metin, Kolilekas, Lykorguos, Kocwin, Marcelina, Krusheva, Borislava, Larenas Linnemann, Désirée, Litovchenko, Irine, Marcipar, A., Meza, L.E., Nedeva, D., Novakova, P., Plavec, D., Popović-Grle, S., Puggioni, F., Pur Oziygit, L., Rodrigez, N., Ryan, D., Ruzsics, I., Scichilone, N., Serpa, F., Steiropoulos, P., Solidoro, P., Turkalj, M., Umanets, T., Victorio, C.F., Zubeldia, J.M., Yachnyk, V., Zitt, M., Bikov, Andras, Oğuzülgen, Ipek Kivilcim, Baiardini, Ilaria, Contoli, Marco, Emelyanov, Alexander, Fassio, Omar, Ivancevich, Juan Carlos, Kaidashev, Igor, Kowal, Krzysztof, Labor, Marina, Lahousse, Lies, Mihaicuta, Stefan, Novakova, Silviya, Padilla Galo, Alicia, Simidchiev, Alexander, Tiotiu, Angelica, Ansotegui, Ignacio J., Bernstein, Jonathan A., Boulet, Louis Philippe, Canonica, Giorgio Walter, Dubuske, Lawrence, Rosario, Nelson, Santus, Pierachille, and Braido, Fulvio
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- 2020
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49. Dual Bronchodilator in the Era of Triple Therapy
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Papaioannou AI, Loukides S, Bakakos P, Kosmas EN, Rovina N, Steiropoulos P, Fouka E, Hillas G, Patentalakis G, Kouvela M, and Tzanakis N
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chronic obstructive pulmonary disease dual bronchodilation inhaled corticosteroids triple therapy ,Diseases of the respiratory system ,RC705-779 - Abstract
Andriana I Papaioannou,1 Stelios Loukides,1 Petros Bakakos,2 Epameinondas N Kosmas,3 Nikoletta Rovina,2 Paschalis Steiropoulos,4 Evangellia Fouka,5 Georgios Hillas,6 Georgios Patentalakis,7 Marousa Kouvela,7 Nikos Tzanakis8 1 2nd Respiratory Medicine Department, University of Athens, “Attikon” University Hospital, Athens, Greece; 2 1st Respiratory Medicine Department, University of Athens, “Sotiria” Chest Hospital, Athens, Greece; 3PNOH Pulmonary Clinic, Metropolitan Hospital, Athens, Greece; 4Department of Respiratory Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece; 5Respiratory Medicine Department, Aristotle University of Thessaloniki, G Papanikolaou Hospital, Thessaloniki, Greece; 6 5th Respiratory Medicine Department, Sotiria Chest Hospital, Athens, Greece; 7 3rd Department of Medicine, Athens Medical School, Athens, Greece; 8Department of Thoracic Medicine, Faculty of Medicine, University of Crete, Crete, GreeceCorrespondence: Andriana I Papaioannou 2nd Respiratory Medicine DepartmentUniversity of Athens, “Attikon” University Hospital, Chaidari, Athens, GreeceTel +302105831163Email papaioannouandriana@gmail.comAbstract: Pharmacological medications used for the treatment of COPD patients have increased significantly. Long-acting bronchodilators have been recognized as the mainstay of the treatment of stable COPD, while ICS are usually added in patients with COPD who experience exacerbations, despite bronchodilator treatment. In the latest years, several studies have been published showing the beneficial effect of adding ICS on dual bronchodilation in patients suffering from more severe disease comparing triple therapy with several therapeutic regiments including dual bronchodilation and providing a message that this triple therapy might be more appropriate for COPD patients. However, not all COPD patients have a desirable response to ICS treatment while long-term ICS use in COPD is associated with several side effects. In this report, we aimed to provide a review of the current knowledge on the importance of dual bronchodilation on COPD patients and to compare its use with triple therapy, by covering a wide spectrum of topics. Finally, we propose an algorithm on performing treatment step up from dual bronchodilation to triple therapy and step down from triple to double bronchodilation considering the current evidence.Keywords: chronic obstructive pulmonary disease, dual bronchodilation, inhaled corticosteroids, triple therapy
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- 2020
50. A Real-World Observational Study Examining the Impact of Aclidinium Bromide Therapy on the Quality of Life, Symptoms, and Activity Impairment of Patients with Chronic Obstructive Pulmonary Disease: The Greek ON-AIR Study
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Kostikas K, Vassilakopoulos TI, Tzanakis N, Konstantinidis AK, Kosmas EN, Papiris S, Steiropoulos P, Manali ED, Michaelides SA, and Daskos G
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aclidinium ,chronic obstructive pulmonary disease ,copd assessment test ,daily activities ,quality of life ,symptoms ,Diseases of the respiratory system ,RC705-779 - Abstract
Konstantinos Kostikas,1 Theodoros I Vassilakopoulos,2,3 Nikos Tzanakis,4 Athanasios K Konstantinidis,1 Epameinondas N Kosmas,5 Spyros Papiris,6 Paschalis Steiropoulos,7 Effrosyni D Manali,6 Stylianos A Michaelides8,†, Grigorios Daskos9 1Respiratory Medicine Department, University Hospital of Ioannina, Ioannina, Greece; 2Pulmonary and Critical Care Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 3Third Department of Critical Care Medicine, Evgenideio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 4Department of Respiratory Medicine, University Hospital of Heraklion, Medical School, University of Crete, Crete, Greece; 5Department of Pulmonary Medicine, Metropolitan Hospital, Athens, Greece; 6Second Pulmonary Medicine Department, General University Hospital “Attikon”, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 7Pulmonology Clinic Medical School, Democritus University of Thrace/University General Hospital, Alexandroupolis, Greece; 8Department of Occupational Lung Disease and Tuberculosis, “Sismanogleio-Amalia Fleming” General Hospital, Athens, Greece; 9MENARINI HELLAS, Athens, Greece†Stylianos A Michaelides passed away on September 14, 2019Correspondence: Konstantinos KostikasRespiratory Medicine Department, University of Ioannina School of Medicine, Leoforos Stavrou Niarchou, Ioannina 45500, GreeceTel +30-2651007536Email ktkostikas@gmail.comPurpose: This multicenter, prospective, observational study aimed to supplement real-world evidence on the effects of aclidinium bromide on the quality of life (QoL), symptoms, and activity impairment of patients with COPD.Patients and Methods: Eligible patients were ≥ 40 years of age, newly initiated on aclidinium bromide as monotherapy or add-on therapy according to the product’s approved label. Patient-reported COPD assessment test (CAT), the severity of symptoms and their impact on daily activities, and the features of the Genuair® inhaler device were assessed at enrollment and at 12 weeks post-treatment onset.Results: Between 13 March 2015 and 29 January 2016, 285 eligible consenting patients (76.3% males; median age: 69.0 years; 26.0% newly diagnosed with COPD) were enrolled by 15 hospital-based respiratory medicine specialists in Greece. Aclidinium bromide was initiated as add-on therapy to other inhaled maintenance medications in 73.1% of evaluable patients. The median (interquartile range [IQR]) baseline CAT score decreased from 14.0 (9.0– 20.0) to 10.0 (6.0– 15.0) points (p< 0.001) after 12 weeks of treatment, with 76.5% of the patients achieving a ≥ 2-point decrease. The severity of night-time and early-morning symptoms, assessed using a 5-point Likert-type scale, decreased from a median (IQR) of 1.0 (0.0– 2.0) to 0.0 (0.0– 1.0), and from 2.0 (1.0– 2.0) to 1.0 (1.0– 2.0), respectively (p< 0.001 for both). In patients with paired data, the prevalence of at least moderate night-time symptoms, early-morning symptoms, and daily activity impairment decreased from 28.2% to 19.1%, from 63.6% to 34.2%, and from 59.5% to 38.7%, respectively (p< 0.001 for all). Inhaler device features were assessed as “very good”/“good” by more than 90% of the patients. The adverse drug reaction rate was 1.4%.Conclusion: The study provides real-world evidence on the beneficial effects of aclidinium bromide on the patients’ QoL, symptom severity, and daily activity impairment, which are complemented by a favorable safety profile and high patient satisfaction with the inhaler device.Keywords: aclidinium, chronic obstructive pulmonary disease, COPD assessment test, daily activities, quality of life, symptoms
- Published
- 2020
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