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Extrafine single inhaler triple therapy effectiveness in COPD patients previously treated with multiple-inhaler triple therapy: the TRIWIN study

Authors :
Paschalis Steiropoulos
Niki Georgatou
George Krommidas
Konstantinos Bartziokas
Aliki Korkontzelou
Panos Katerelos
Petros Efstathopoulos
Dimosthenis Papapetrou
Stavros Theodorakis
Konstantinos Porpodis
Source :
Therapeutic Advances in Respiratory Disease, Vol 18 (2024)
Publication Year :
2024
Publisher :
SAGE Publishing, 2024.

Abstract

Background: The extrafine single inhaler triple therapy (efSITT) containing beclomethasone dipropionate/formoterol fumarate/glycopyrronium 87/5/9 μg has proved to be efficacious in patients with chronic obstructive pulmonary disease (COPD) in randomized control trials. Objective: TRIWIN study evaluated the effectiveness of efSITT delivering beclomethasone dipropionate/formoterol fumarate/glycopyrronium 87/5/9 μg in COPD patients previously treated with multiple-inhaler triple therapy (MITT) in a real-world study in Greece. Design: Prospective, multicenter, observational, non-interventional study was conducted over 24 weeks. Methods: A total of 475 eligible patients had moderate-to-severe COPD, an indication for treatment with efSITT, and were symptomatic despite receiving MITT. COPD Assessment Test (CAT) score, pulmonary function parameters, use of rescue medication, and adherence to inhaler use were recorded at baseline (Visit 1), 3 (Visit 2), and 6 months (Visit 3) after treatment. Results: Mean CAT score decreased from 21.4 points at Visit 1, to 16.6 at Visit 2 and 15.1 at Visit 3 ( p

Details

Language :
English
ISSN :
17534666
Volume :
18
Database :
Directory of Open Access Journals
Journal :
Therapeutic Advances in Respiratory Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.975f8ded37a407883f43506c3346a27
Document Type :
article
Full Text :
https://doi.org/10.1177/17534666241263439