Search

Your search keyword '"Stein, Carolina"' showing total 42 results
Start Over Author "Stein, Carolina"
42 results on '"Stein, Carolina"'

1. Topical application of a TRPA1 antagonist reduced nociception and inflammation in a model of traumatic muscle injury in rats

Author

Kudsi, Sabrina Qader, de David Antoniazzi, Caren Tatiane, Camponogara, Camila, Meira, Graziela Moro, de Amorim Ferreira, Marcella, da Silva, Ana Merian, Dalenogare, Diéssica Padilha, Zaccaron, Rubya, dos Santos Stein, Carolina, Silveira, Paulo Cesar Lock, Moresco, Rafael Noal, Oliveira, Sara Marchesan, Ferreira, Juliano, and Trevisan, Gabriela

Published
2023
Full Text
View/download PDF

6. Increased levels of advanced oxidation protein products (AOPPs) were associated with nociceptive behavior and clinical scores in an experimental progressive autoimmune encephalomyelitis model (PMS‐EAE).

Author

Rodrigues, Patrícia, Frare, Julia Maria, Peres, Diulle Spat, Viero, Fernanda Tibolla, Ruviaro, Náthaly Andrighetto, dos Santos Stein, Carolina, da Silva Brum, Evelyne, Moresco, Rafael Noal, Oliveira, Sara Marchesan, Bochi, Guilherme Vargas, and Trevisan, Gabriela

Subjects
NADPH oxidase, ENCEPHALOMYELITIS, CENTRAL nervous system, NEURALGIA, NEST building, FOOT, INDUCED labor (Obstetrics), NEURITIS
Abstract

Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous system (CNS) generating neuropathic pain and anxiety. Primary progressive MS (PPMS) is the most disabling clinical form, and the patients present an intense neurodegenerative process. In this context, the advanced oxidation protein products (AOPPs) are oxidized compounds and their accumulation in plasma has been related to clinical disability in MS patients. However, the involvement of AOPPs in neuropathic pain‐ and anxiety‐like symptoms was not previously evaluated. To assess this, female mice C57BL/6J were used to induce progressive experimental autoimmune encephalomyelitis (PMS‐EAE). Clinical score, weight, strength of plantar pressure, rotarod test, mechanical allodynia, and cold hypersensitivity were evaluated before induction (baseline) and on days 7th, 10th, and 14th post‐immunization. We assessed nest building, open field, and elevated plus‐maze tests 13 days post‐immunization. Animals were killed at 14 days post‐immunization; then, AOPPs levels, NADPH oxidase, and myeloperoxidase (MPO) activity were measured in the prefrontal cortex, hippocampus, and spinal cord samples. The clinical score increased 14th post‐immunization without changes in weight and mobility. Reduced paw strength, mechanical allodynia, and cold allodynia increased in the PMS‐EAE animals. PMS‐EAE mice showed spontaneous nociception and anxiety‐like behavior. AOPPs concentration, NADPH oxidase, and MPO activity increase in CNS structures. Multivariate analyses indicated that the rise of AOPPs levels, NADPH oxidase, and MPO activity influenced the clinical score and cold allodynia. Thus, we indicated the association between non‐stimuli painful perception, anxiety‐like, and CNS oxidative damage in the PMS‐EAE model. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Anthropometric measurements and their association with endothelial function and arterial stiffness of eutrophic individuals and with overweight

Author

Ferigollo, Ariélen, primary, Chemello, Diego, additional, Pavão, Tábata Pereira, additional, Saffi, Marco Aurélio Lumertz, additional, Stein, Carolina dos Santos, additional, Moresco, Rafael Noal, additional, Souza, Lucas Silva de, additional, Moreira, Carlos Heitor Cunha, additional, Signori, Luis Ulisses, additional, and Chagas, Patrícia, additional

Published
2023
Full Text
View/download PDF

13. Potential effects of carbamylation on the prothrombin time, activated partial thromboplastin time, and fibrinogen.

Author

Mastella, Aline K., de Carvalho, José A. M., Pereira, Karla N., das Neves, Yasmin S., Stein, Carolina S., Bochi, Guilherme V., and Moresco, Rafael N.

Subjects
PROTEIN metabolism, PROTHROMBIN time, PARTIAL thromboplastin time, CHRONIC kidney failure, UREA, RISK assessment, FIBRINOGEN, INORGANIC compounds, PEPTIDES, DISEASE risk factors
Abstract

The article discusses a study which examined the effects of carbamylation induced by potassium cyanates (KOCN), a well-established carbamylating agent used in vitro models, and urea on prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen measured in pooled normal human plasma. Topics include how a normal plasma pool (NPP) used in the study was prepared, PT, aPTT, and fibrinogen values after the KOCN, and factor that may affect the results of coagulation tests.

Published
2024
Full Text
View/download PDF

18. Ovariectomy Improves Metabolic and Oxidative Stress Marker Disruption in Androgenized Rats: Possible Approach to Postmenopausal Polycystic Ovary Syndrome

Author

Serrano Mujica, Lady Katerine, primary, Stein, Carolina S., additional, Miyazato, Ligia Gomes, additional, Valente, Fernanda, additional, Premaor, Melissa Orlandin, additional, Antoniazzi, Alfredo Quites, additional, Moresco, Rafael Noal, additional, and Comim, Fabio Vasconcellos, additional

Published
2021
Full Text
View/download PDF

22. Oxidative damage, inflammation, genotoxic effect, and global DNA methylation caused by inhalation of formaldehyde and the purpose of melatonin

Author

Bernardini, Letícia, primary, Barbosa, Eduardo, additional, Charão, Mariele Feiffer, additional, Goethel, Gabriela, additional, Muller, Diana, additional, Bau, Claiton, additional, Steffens, Nadine Arnold, additional, Santos Stein, Carolina, additional, Moresco, Rafael Noal, additional, Garcia, Solange Cristina, additional, Souza Vencato, Marina, additional, and Brucker, Natália, additional

Published
2020
Full Text
View/download PDF

23. Characterisation of nociception and inflammation observed in a traumatic muscle injury model in rats

Author

Kudsi, Sabrina Qader, primary, Antoniazzi, Caren Tatiane de David, additional, Camponogara, Camila, additional, Brum, Evelyne da Silva, additional, Brusco, Indiara, additional, Peres, Diulle Spat, additional, Fischer, Susana Paula Moreira, additional, Dalenogare, Diéssica Padilha, additional, Stein, Carolina dos Santos, additional, Zaccaron, Rubya Pereira, additional, Silveira, Paulo Cesar Lock, additional, Moresco, Rafael Noal, additional, Oliveira, Sara Marchesan, additional, and Trevisan, Gabriela, additional

Published
2020
Full Text
View/download PDF

27. Activity of the enzyme delta-aminolevulinate dehydratase and parameters of oxidative stress in different modes of delivery.

Author

Vendrame, Silmara Ana, de Lucca, Leidiane, de Paula, Hellen Lopes, Stein, Carolina dos Santos, Gallarreta, Francisco Maximiliano Pancich, Konopka, Cristine Kolling, Moresco, Rafael Noal, and Gonçalves, Thissiane de Lima

Subjects
OXIDATIVE stress, CESAREAN section, OXIDANT status, CORD blood, ENZYMES, FREE radicals
Abstract

Aims: The objective of this study was to investigate the effect of the type of delivery (vaginal and cesarean) on the activity of the enzyme delta-aminolevulinate dehydratase (δ-ALA-D), which as yet has not been studied, and the markers of oxidative stress.Methods: Seventy-six mothers and their newborns were divided into two groups: normal birth (VD) and elective cesarean section (ECS). Samples of maternal and umbilical cord blood were collected up to 5 min after birth. Thiobarbituric acid reactive substances (TBARS), advanced oxidation protein products (AOPP), protein thiol (P-SH), nonprotein (NP-SH), the ferric reducing ability of plasma (FRAP), total antioxidant capacity (TAC), catalase, and δ-ALA-D enzyme activity were tested.Results: TBARS and AOPP were significantly higher in mothers of the VD group, while P-SH, NP-SH, FRAP and TAC were reduced. In newborns, TBARS and AOPP did not differ between the groups; however, in the VD group, there was a decrease in P-SH, NP-SH, FRAP, TAC, and catalase. The activity of the δ-ALA-D enzyme was decreased in mothers and neonates born by VD.Conclusions: Mothers undergoing VD had higher levels of free radicals and lower antioxidant defenses, while their newborns decreased antioxidant defenses likely to contain the oxidative imbalance. The inhibition of the δ-ALA-D enzyme in this scenario allows its use as a useful marker of oxidative stress in different obstetric settings. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

28. High serum uric acid levels are associated with nucleoside oxidation in patients with type 2 diabetes

Author

Stein, Carolina dos Santos, Moretto, Maria Beatriz, Moresco, Rafael Noal, Vaucher, Rodrigo de Almeida, and Bitencourt, Paula Eliete Rodrigues

Subjects
Diabetes mellitus tipo 2, Ácido úrico, Oxidação de nucleosídeos, Nucleoside oxidation, Type 2 diabetes, 8- hidroxi-2’-deoxiguanosina urinário, CIENCIAS DA SAUDE::FARMACIA [CNPQ], Urinary 8-hydroxy2’- deoxyguanosine, Uric acid
Abstract

Uric acid, even in physiologic levels, is capable of causing damage to biomolecules through some mechanisms. Especially, hyperuricemia is capable of favor the formation of intracellular radical species, thus, contributing to the occurrence of products of nucleoside oxidation, including the 8-hydroxy-2’-deoxyguanosine (8- OHdG), a biomarker of this damage. It is known that patients with type 2 diabetes (T2D) have higher levels of nucleoside and deoxyribonucleic acid (DNA) oxidation compared to healthy individuals, however, little was explored in humans about the role of serum uric acid levels in promoting this damage in this population. Thus, the objective of this study was to evaluate the relationship between the levels of serum uric acid and the urinary concentrations of 8-OHdG, besides the influence of the glycemic control and other factors on this relationship, in patients with T2D and healthy individuals. In the University Hospital of Santa Maria, 61 patients were recruited, of those, 46 had T2D and were assisted at the Ambulatory of Endocrinology. The levels of uric acid, 8-OHdG and other parameters were measured. The patients were stratified according to the median of serum uric acid in the study population (< 5,3 mg/dL e ≥ 5,3 mg/dL). The patients with T2D who had higher levels of uric acid showed higher urinary levels of 8-OHdG compared to those with lower levels (20.0 [16.0–35.0] versus 16.6 [13.0–23.0] ng/mL, P=0.014, respectively). This association was not observed in the healthy individuals (P=0.483). Moreover, a significant positive correlation was observed between the two parameters (r = 0.40, P

Published
2019

29. Influence of maternal labor time on delta-aminolevulinate dehydratase enzyme activity and markers of oxidative stress in newborns

Author

Vendrame, Silmara Ana, primary, de Lucca, Leidiane, additional, de Paula, Hellen Lopes, additional, Stein, Carolina dos Santos, additional, Paz, Monique Soares, additional, Kavalco, Tatiana Frehner, additional, Gallarreta, Francisco Maximiliano Pancich, additional, Moresco, Rafael Noal, additional, and Gonçalves, Thissiane de Lima, additional

Published
2019
Full Text
View/download PDF

30. Longitudinal Study of Delta-Aminolevulinate Dehydratase Activity and Oxidative Profile in Healthy Pregnant Women

Author

de Lucca, Leidiane, primary, Jantsch, Letícia Bigolin, additional, Vendrame, Silmara Ana, additional, Stein, Carolina dos Santos, additional, Klein, Vanessa Cristina Grólli, additional, Soares, Karina Biaggio, additional, Gallarreta, Francisco Maximiliano Pancich, additional, Moresco, Rafael Noal, additional, and Gonçalves, Thissiane de Lima Gonçalves, additional

Published
2019
Full Text
View/download PDF

33. Addition of curcumin to the diet of dairy sheep improves health, performance and milk quality

Author

Jaguezeski, Antonise M., primary, Perin, Gessica, additional, Bottari, Nathieli B., additional, Wagner, Roger, additional, Fagundes, Mariane B., additional, Schetinger, Maria Rosa C., additional, Morsch, Vera M., additional, Stein, Carolina S., additional, Moresco, Rafael N., additional, Barreta, Daniel A., additional, Danieli, Beatriz, additional, Defiltro, Renata C., additional, Schogor, Ana Luiza B., additional, and Da Silva, Aleksandro S., additional

Published
2018
Full Text
View/download PDF

34. Effects of Freeze-Thaw Cycles and Assessment of Short-Term Storage Stability on Serum Iron, Ferritin, and Transferrin.

Author

Klat, Rogério L., Stein, Carolina dos S., Santos, Mariane dos, and Moresco, Rafael N.

Subjects
FREEZE-thaw cycles, FERRITIN, TRANSFERRIN, IRON, STORAGE
Abstract

Background: Most errors in the laboratory occur due to processes related to the pre-analytical phase. The purpose of this study was to investigate the effects of multiple freeze-thaw cycles on serum iron, transferrin, and ferritin, as well as the impact of short-term storage on the stability of these analytes. Methods: Serum samples from ten volunteers were submitted to three consecutive freeze-thaw cycles at -20°C and -80°C. Serum aliquots were also kept at 4°C, -20°C, and -80°C for 28 days. Iron, ferritin, and transferrin were measured after 1, 7, 14, 21, or 28 days of storage. Results: Serum ferritin and transferrin showed variations from -2.6 to 2.6% and -1.7 to 2.4%, respectively, in their concentrations during the three freeze-thaw cycles of -20°C and -80°C. However, the variations were statistically significant only at -20°C. No significant changes were found for iron at both temperatures. The storage at temperatures of 4°C, -20°C, and -80°C for up to 4 weeks significantly affected the serum concentrations of iron, ferritin, and transferrin (p < 0.01 for all). Conclusions: Serum iron, ferritin, and transferrin were affected by the storage of samples at temperatures of 4°C, -20°C and -80°C for up to 4 weeks, and the freeze-thaw cycles at -20°C influenced the measurement of serum ferritin and transferrin. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

35. Utmattningssyndrom : En bloggstudie om att leva med stressrelaterad ohälsa

Author

Henriksson, Unn and Stein, Carolina

Subjects
utmattningssyndrom, leva med, upplevelse, Health Sciences, blogg, Hälsovetenskaper, ohälsa
Abstract

Bakgrund: Utmattningssyndrom är ett växande problem som kommer av långvarig stress och är en bidragande orsak till sjukskrivningar. Sjukdomen innefattar en bred symtombild med somatiska och psykiska symtom, och riskerar att förbises på grund av somatiska symtom. Utmattningssyndrom har en stor påverkan på de drabbades liv och identitet. Syfte: Att belysa upplevelsen av att drabbas av och leva med utmattningssyndrom. Metod: Studien grundades på en kvalitativ metod baserad på fem självbiografiska bloggar. Forsberg och Wengström (2016) manifesta innehållsanalys användes för att finna sammanhang i resultatet. Resultat: Resultatet visar att insjuknandet i utmattningssyndrom är en livsomvälvande händelse. Drabbade upplever en förlust av sin tidigare identitet. Sjukdomen kantas av flera negativa känslor och kroppslig påverkan, däribland ångest, skam, brist på ork, värk och minnessvårigheter. Sjukdomen är begränsande och innebär ett ökat behov att stöd och förståelse för att kunna hantera vardagen och sjukdomen. När detta uteblir uppstår känslor av att vara misstrodd och förnedring. Slutsats: Utmattningssyndrom kommer av stress, krav, prestation och bristfällig återhämtning. Utfallet skulle kunna minskas genom att prioritera arbetsmiljön. Sjukdomen leder till en existentiell kris, där meningen i livet och välbefinnandet påverkas. Ett gott bemötande, där patienten tas på allvar och hjälps till reflektion kan underlätta bearbetningen.

Published
2017

37. Anti-inflammatory action of seed extract and polymeric nanoparticles of Syzygium cumini in diabetic rats infected with Candida albicans

Author

Bitencourt, Paula, primary, Cargnelutti, Lariane, additional, Stein, Carolina, additional, Lautenchleger, Raquel, additional, Ferreira, Luana, additional, Sangoi, Manuela, additional, Boligon, Aline, additional, Duarte, Marta, additional, Moresco, Rafael, additional, Cruz, Let, additional, Zanette, R, additional, Alves, Sydney, additional, and Moretto, Maria, additional

Published
2017
Full Text
View/download PDF

38. Nanoparticle formulation increasesSyzygium cuminiantioxidant activity inCandida albicans-infected diabetic rats

Author

Bitencourt, Paula E. R., primary, Cargnelutti, Lariane O., additional, Stein, Carolina S., additional, Lautenchleger, Raquel, additional, Ferreira, Luana M., additional, Sangoi, Manuela, additional, Denardi, Laura, additional, Borges, Raphaela M., additional, Boligon, Aline, additional, Moresco, Rafael N., additional, Cruz, Letícia, additional, Zanette, Régis A., additional, Alves, Sydney H., additional, and Moretto, Maria Beatriz, additional

Published
2017
Full Text
View/download PDF

40. Nanoparticles containing aqueous seed extract of Syzygium cumini (npasc) protect against oxidized LDL particles in vitro

Author

Bitencourt, Paula Eliete Rodrigues, primary, Ferreira, Luana Mota, additional, dos Santos Stein, Carolina, additional, Sangoi, Manuela, additional, Denardi, Laura, additional, Borges, Raphaela Maleski, additional, Cruz, Letícia, additional, Moresco, Rafael Noal, additional, Hartz, Sydney Alvez, additional, and Moretto, Maria Beatriz, additional

Published
2015
Full Text
View/download PDF

41. Nanoparticle formulation increases Syzygium cumini antioxidant activity in Candida albicans -infected diabetic rats.

Author

Bitencourt, Paula E. R., Cargnelutti, Lariane O., Stein, Carolina S., Lautenchleger, Raquel, Ferreira, Luana M., Sangoi, Manuela, Denardi, Laura, Borges, Raphaela M., Boligon, Aline, Moresco, Rafael N., Cruz, Letícia, Zanette, Régis A., Alves, Sydney H., and Moretto, Maria Beatriz

Subjects
SYZYGIUM, ANTIOXIDANTS, CANDIDA albicans, DIABETES, OXIDATIVE stress, GLUCOSE, CREATININE, THERAPEUTICS
Abstract

Context:Syzygium cumini(L.) Skeels (Myrtaceae) is a medicinal plant widely used in folk medicine for the treatment of diabetes mellitus (DM). However, studies on the use of this plant and of nanoparticle formulations against DM-related fungal infections are scarce. Objective:To evaluate the effect of the treatments with aqueous seed extract ofS. cumini(ASc) and ASc-loaded polymeric nanoparticles (NPASc) on biochemical parameters inCandida albicans-infected diabetic rats. Materials and methods:Male Wistar rats were divided into eight groups: Control, DM,C. albicans,C. albicans + ASc,C. albicans + NPASc, DM + C. albicans, DM + C. albicans + ASc and DM + C. albicans + NPASc. Rats were daily treated with ASc or NPASc (100 mg/kg) for 21 days. Biochemical parameters in serum and urine, advanced oxidation protein product (AOPP) and TBARS levels in the serum, kidney, liver and pancreas andN-acetyl-β-d-glucosaminidase (NAG) activities in kidney and urine were evaluated. Results:Biochemical and oxidative stress parameters increased in rats with DM and/or candidiasis. NPASc was more effective than ASc in decreasing glucose (56%), cholesterol (33%) and creatinine (51%) levels; serum (16%) and pancreatic (46%) AOPP and renal (48%) TBARS levels when compared with DM + C. albicansgroup. InC. albicansgroup, both treatments decreased NAG activity but did not decrease creatinine levels. Conclusions:These data suggest that the use of nanotechnology is able to improve plant extract properties such as antioxidant activity that may be useful in diabetes-related complications. [ABSTRACT FROM PUBLISHER]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results