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1. Scientific Evidence for the Updated Guidelines on Indications for Metabolic and Bariatric Surgery (IFSO/ASMBS)

Author

De Luca, Maurizio, Shikora, Scott, Eisenberg, Dan, Angrisani, Luigi, Parmar, Chetan, Alqahtani, Aayed, Aminian, Ali, Aarts, Edo, Brown, Wendy, Cohen, Ricardo V., Di Lorenzo, Nicola, Faria, Silvia L., Goodpaster, Kasey P. S., Haddad, Ashraf, Herrera, Miguel, Rosenthal, Raul, Himpens, Jacques, Iossa, Angelo, Kermansaravi, Mohammad, Kow, Lilian, Kurian, Marina, Chiappetta, Sonja, LaMasters, Teresa, Mahawar, Kamal, Merola, Giovanni, Nimeri, Abdelrahman, O’Kane, Mary, Papasavas, Pavlos, Piatto, Giacomo, Ponce, Jaime, Prager, Gerhard, Pratt, Janey S. A., Rogers, Ann M., Salminen, Paulina, Steele, Kimberley E., Suter, Michel, Tolone, Salvatore, Vitiello, Antonio, Zappa, Marco, and Kothari, Shanu N.

Published
2024
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4. Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms.

Author

Gerkin, Richard, Ohla, Kathrin, Veldhuizen, Maria, Joseph, Paule, Kelly, Christine, Bakke, Alyssa, Steele, Kimberley, Farruggia, Michael, Pellegrino, Robert, Pepino, Marta, Bouysset, Cédric, Soler, Graciela, Pereda-Loth, Veronica, Dibattista, Michele, Cooper, Keiland, Croijmans, Ilja, Di Pizio, Antonella, Ozdener, Mehmet, Fjaeldstad, Alexander, Lin, Cailu, Sandell, Mari, Singh, Preet, Brindha, V, Olsson, Shannon, Saraiva, Luis, Ahuja, Gaurav, Alwashahi, Mohammed, Bhutani, Surabhi, DErrico, Anna, Fornazieri, Marco, Golebiowski, Jérôme, Dar Hwang, Liang, Öztürk, Lina, Roura, Eugeni, Spinelli, Sara, Whitcroft, Katherine, Faraji, Farhoud, Fischmeister, Florian, Heinbockel, Thomas, Hsieh, Julien, Huart, Caroline, Konstantinidis, Iordanis, Menini, Anna, Morini, Gabriella, Olofsson, Jonas, Philpott, Carl, Pierron, Denis, Shields, Vonnie, Voznessenskaya, Vera, Albayay, Javier, Altundag, Aytug, Bensafi, Moustafa, Bock, María, Calcinoni, Orietta, Fredborg, William, Laudamiel, Christophe, Lim, Juyun, Lundström, Johan, Macchi, Alberto, Meyer, Pablo, Moein, Shima, Santamaría, Enrique, Sengupta, Debarka, Rohlfs Dominguez, Paloma, Yanik, Hüseyin, Hummel, Thomas, Hayes, John, Reed, Danielle, Niv, Masha, Munger, Steven, and Parma, Valentina

Subjects
anosmia, chemosensory, coronavirus, hyposmia, olfactory, prediction, Adult, Anosmia, COVID-19, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prognosis, SARS-CoV-2, Self Report, Smell
Abstract

In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19-; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: -82.5 ± 27.2 points; C19-: -59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0-10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable.

Published
2021

6. 2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Indications for Metabolic and Bariatric Surgery

Author

Eisenberg, Dan, Shikora, Scott A., Aarts, Edo, Aminian, Ali, Angrisani, Luigi, Cohen, Ricardo V., de Luca, Maurizio, Faria, Silvia L., Goodpaster, Kasey P.S., Haddad, Ashraf, Himpens, Jacques M., Kow, Lilian, Kurian, Marina, Loi, Ken, Mahawar, Kamal, Nimeri, Abdelrahman, O’Kane, Mary, Papasavas, Pavlos K., Ponce, Jaime, Pratt, Janey S. A., Rogers, Ann M., Steele, Kimberley E., Suter, Michel, and Kothari, Shanu N.

Published
2023
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8. 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for Metabolic and Bariatric Surgery

Author

Eisenberg, Dan, Shikora, Scott A., Aarts, Edo, Aminian, Ali, Angrisani, Luigi, Cohen, Ricardo V., De Luca, Maurizio, Faria, Silvia L., Goodpaster, Kasey P.S., Haddad, Ashraf, Himpens, Jacques M., Kow, Lilian, Kurian, Marina, Loi, Ken, Mahawar, Kamal, Nimeri, Abdelrahman, O’Kane, Mary, Papasavas, Pavlos K., Ponce, Jaime, Pratt, Janey S.A., Rogers, Ann M., Steele, Kimberley E., Suter, Michel, and Kothari, Shanu N.

Published
2022
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11. Publisher Correction: 2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Indications for Metabolic and Bariatric Surgery

Author

Eisenberg, Dan, Shikora, Scott A., Aarts, Edo, Aminian, Ali, Angrisani, Luigi, Cohen, Ricardo V., de Luca, Maurizio, Faria, Silvia L., Goodpaster, Kasey P. S., Haddad, Ashraf, Himpens, Jacques M., Kow, Lilian, Kurian, Marina, Loi, Ken, Mahawar, Kamal, Nimeri, Abdelrahman, O’Kane, Mary, Papasavas, Pavlos K., Ponce, Jaime, Pratt, Janey S. A., Rogers, Ann M., Steele, Kimberley E., Suter, Michel, and Kothari, Shanu N.

Published
2023
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13. Taste-related reward is associated with weight loss following bariatric surgery

Author

Smith, Kimberly R., Papantoni, Afroditi, Veldhuizen, Maria G., Kamath, Vidyulata, Harris, Civonnia, Moran, Timothy H., Carnell, Susan, and Steele, Kimberley E.

Subjects
Surgery -- Health aspects, Obesity -- Care and treatment, Bariatric surgery -- Health aspects, Body mass index -- Health aspects, Weight loss maintenance -- Health aspects, Health care industry, Johns Hopkins University. School of Medicine
Abstract

BACKGROUND. Bariatric surgeries are the most effective treatments for successful and sustained weight loss, but individuals vary in treatment response. Understanding the neurobiological and behavioral mechanisms accounting for this variation could lead to the development of personalized therapeutic approaches and improve treatment outcomes. The primary objectives of this study were to investigate changes in taste preferences and taste-induced brain responses after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) and to identify potential taste-related predictors of weight loss. METHODS. Females, ages 18 to 55, with a body mass index greater than or equal to 35 kg/[m.sup.2], and approved for bariatric surgery at the Johns Hopkins Center for Bariatric Surgery were recruited for participation. Demographics, anthropometrics, liking ratings, and neural responses to varying concentrations of sucrose plus fat mixtures were assessed before and after surgery via visual analog scales and functional MRI. RESULTS. Bariatric surgery produced decreases in liking for sucrose-sweetened mixtures. Greater preference for sucrose-sweetened mixtures before surgery was associated with greater weight loss in RYGB, but not VSG. In the RYGB group only, individuals who showed lower taste-induced activation in the ventral tegmental area (VTA) before surgery and greater changes in taste-induced VTA activation 2 weeks following surgery experienced increased weight loss. CONCLUSION. The anatomical and/or metabolic changes associated with RYGB may more effectively 'reset' the neural processing of reward stimuli, thereby rescuing the blunted activation in the mesolimbic pathway found in patients with obesity. Further, these findings suggest that RYGB may be particularly effective in patients with a preference for sweet foods. FUNDING. NIH K23DK100559 and Dalio Philanthropies., Introduction Bariatric surgery results in substantial and sustained weight loss, making it the most successful treatment to date for obesity (1-3). The 2 most common bariatric interventions are the Roux-en-Y [...]

Published
2020
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20. Milkshake Acutely Stimulates Dopamine Release in Ventral and Dorsal Striatum in Healthy-Weight Individuals and Patients with Severe Obesity Undergoing Bariatric Surgery: A Pilot Study

Author

Carnell, Susan, primary, Steele, Kimberley E., additional, Thapaliya, Gita, additional, Kuwubara, Hiroto, additional, Aghababian, Anahys, additional, Papantoni, Afroditi, additional, Nandi, Ayon, additional, Brašić, James R., additional, Moran, Timothy H., additional, and Wong, Dean F., additional

Published
2023
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25. Publisher Correction: 2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Indications for Metabolic and Bariatric Surgery

Author

Eisenberg, Dan, primary, Shikora, Scott A., additional, Aarts, Edo, additional, Aminian, Ali, additional, Angrisani, Luigi, additional, Cohen, Ricardo V., additional, de Luca, Maurizio, additional, Faria, Silvia L., additional, Goodpaster, Kasey P. S., additional, Haddad, Ashraf, additional, Himpens, Jacques M., additional, Kow, Lilian, additional, Kurian, Marina, additional, Loi, Ken, additional, Mahawar, Kamal, additional, Nimeri, Abdelrahman, additional, O’Kane, Mary, additional, Papasavas, Pavlos K., additional, Ponce, Jaime, additional, Pratt, Janey S. A., additional, Rogers, Ann M., additional, Steele, Kimberley E., additional, Suter, Michel, additional, and Kothari, Shanu N., additional

Published
2022
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26. 2022 American Society of Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) Indications for Metabolic and Bariatric Surgery

Author

Eisenberg, Dan, primary, Shikora, Scott A., additional, Aarts, Edo, additional, Aminian, Ali, additional, Angrisani, Luigi, additional, Cohen, Ricardo V., additional, de Luca, Maurizio, additional, Faria, Silvia L., additional, Goodpaster, Kasey P.S., additional, Haddad, Ashraf, additional, Himpens, Jacques M., additional, Kow, Lilian, additional, Kurian, Marina, additional, Loi, Ken, additional, Mahawar, Kamal, additional, Nimeri, Abdelrahman, additional, O’Kane, Mary, additional, Papasavas, Pavlos K., additional, Ponce, Jaime, additional, Pratt, Janey S. A., additional, Rogers, Ann M., additional, Steele, Kimberley E., additional, Suter, Michel, additional, and Kothari, Shanu N., additional

Published
2022
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28. Association Between Gut Hormones and Weight Change After Bariatric Arterial Embolization: Results from the BEAT Obesity Trial

Author

Latif, Muhammad A., primary, Tunacao, Jessa M., additional, Fu, Yingli, additional, Moran, Timothy H., additional, Yenokyan, Gayane, additional, Fischman, Aaron M., additional, Cheskin, Lawrence J., additional, Holly, Brian P., additional, Hong, Kelvin, additional, Shin, Eun J., additional, Steele, Kimberley E., additional, Kraitchman, Dara L., additional, Arepally, Aravind, additional, and Weiss, Clifford R., additional

Published
2022
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29. Testosteronoma

Author

Steele, Kimberley E., Zeiger, Martha A., Conn, P. Michael, editor, and Davies, Terry F., editor

Published
2008
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40. The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor

Author

Peng, Jinghua, primary, Ramatchandirin, Balamurugan, additional, Wang, Yu, additional, Pearah, Alexia, additional, Namachivayam, Kopperuncholan, additional, Wolf, Risa M., additional, Steele, Kimberley, additional, MohanKumar, Krishnan, additional, Yu, Liqing, additional, Guo, Shaodong, additional, White, Morris F., additional, Maheshwari, Akhil, additional, and He, Ling, additional

Published
2022
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42. Supplemental Material - The Neuro-Endo-Microbio-Ome Study: A Pilot Study of Neurobiological Alterations Pre- Versus Post-Bariatric Surgery

Author

Agarwal, Khushbu, Maki, Katherine A., Vizioli, Carlotta, Carnell, Susan, Goodman, Ethan, Hurley, Matthew, Harris, Civonnia, Colwell, Rita, Steele, Kimberley, and Joseph, Paule V.

Subjects
111099 Nursing not elsewhere classified, FOS: Health sciences
Abstract

Supplemental Material for The Neuro-Endo-Microbio-Ome Study: A Pilot Study of Neurobiological Alterations Pre- Versus Post-Bariatric Surgery by Khushbu Agarwal, PhD, Katherine A. Maki, PhD, Carlotta Vizioli, PhD, Susan Carnell, PhD, Ethan Goodman, PhD, Matthew Hurley, PhD, Civonnia Harris, BSc, Rita Colwell, PhD, Kimberley Steele, MD, PhD, and Paule V. Joseph, PhD in Biological Research For Nursing

Published
2022
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46. Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms

Author

Gerkin, Richard, Ohla, Kathrin, Veldhuizen, Maria, Joseph, Paule, Kelly, Christine, Bakke, Alyssa, Steele, Kimberley, Farruggia, Michael, Pellegrino, Robert, Pepino, Marta, Bouysset, Cédric, Soler, Graciela, Pereda-Loth, Veronica, Dibattista, Michele, Cooper, Keiland, Croijmans, Ilja, Di Pizio, Antonella, Ozdener, Mehmet Hakan, Fjaeldstad, Alexander, Lin, Cailu, Sandell, Mari, Singh, Preet, Brindha, Evelyn, Olsson, Shannon, Saraiva, Luis, Ahuja, Gaurav, Alwashahi, Mohammed, Bhutani, Surabhi, D’Errico, Anna, Fornazieri, Marco, Golebiowski, Jérôme, Dar Hwang, Liang, Öztürk, Lina, Roura, Eugeni, Spinelli, Sara, Whitcroft, Katherine, Faraji, Farhoud, Fischmeister, Florian, Heinbockel, Thomas, Hsieh, Julien, Huart, Caroline, Konstantinidis, Iordanis, Menini, Anna, Morini, Gabriella, Olofsson, Jonas, Philpott, Carl, Pierron, Denis, Shields, Vonnie, Voznessenskaya, Vera, Albayay, Javier, Altundag, Aytug, Bensafi, Moustafa, Bock, María Adelaida, Calcinoni, Orietta, Fredborg, William, Laudamiel, Christophe, Lim, Juyun, Lundström, Johan, Macchi, Alberto, Meyer, Pablo, Moein, Shima, Santamaría, Enrique, Sengupta, Debarka, Rohlfs Dominguez, Paloma, Yanik, Hüseyin, Hummel, Thomas, Hayes, John, Reed, Danielle, Niv, Masha, Munger, Steven, Parma, Valentina, Boesveldt, Sanne, de Groot, Jasper, Dinnella, Caterina, Freiherr, Jessica, Laktionova, Tatiana, Marino, Sajidxa, Monteleone, Erminio, Nunez-Parra, Alexia, Abdulrahman, Olagunju, Ritchie, Marina, Thomas-Danguin, Thierry, Walsh-Messinger, Julie, Al Abri, Rashid, Alizadeh, Rafieh, Bignon, Emmanuelle, Cantone, Elena, Paola Cecchini, Maria, Chen, Jingguo, Dolors Guàrdia, Maria, Hoover, Kara, Karni, Noam, Navarro, Marta, Nolden, Alissa, Portillo Mazal, Patricia, Rowan, Nicholas, Sarabi-Jamab, Atiye, Archer, Nicholas, Chen, Ben, Di Valerio, Elizabeth, Feeney, Emma, Frasnelli, Johannes, Hannum, Mackenzie, Hopkins, Claire, Klein, Hadar, Mignot, Coralie, Mucignat, Carla, Ning, Yuping, Ozturk, Elif, Peng, Mei, Saatci, Ozlem, Sell, Elizabeth, Yan, Carol, Alfaro, Raul, Coureaud, G., Herriman, Riley, Justice, Jeb, Kaushik, Pavan Kumar, Koyama, Sachiko, Overdevest, Jonathan, Pirastu, Nicola, Ramirez, Vicente, Roberts, S. Craig, Smith, Barry, Cao, Hongyuan, Wang, Hong, Balungwe Birindwa, Patrick, Baguma, Marius, Ozdener, Mehmet, Bock, María, Kaushik, Pavan, Pizio, Antonella, Hakan Ozdener, Mehmet, D'Errico, Anna, Hwang, Liang Dar, Group, GCCR, Cecchini, Maria, Indústries Alimentàries, Qualitat i Tecnologia Alimentària, Arizona State University [Tempe] (ASU), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Mersin University, National Institutes of Health [Bethesda] (NIH), AbScent, Pennsylvania State University (Penn State), Penn State System, Yale University [New Haven], University of Tennessee, University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Institut de Chimie de Nice (ICN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto), Centre d'anthropologie et de génomique de Toulouse (CAGT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Bari Aldo Moro (UNIBA), University of California, Utrecht University [Utrecht], Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Monell Chemical Senses Center, Regional Hospital West Jutland [Denmark], University of Helsinki, University of Oslo (UiO), Karunya Institute of Technology and Sciences, Tata Institute of Fundamental Research, Sidra Medicine [Doha, Qatar], Indraprastha Institute of Information Technology [New Delhi] (IIIT-Delhi), Sultan Qaboos University (SQU), San Diego State University (SDSU), Goethe-University Frankfurt am Main, State University of Londrina = Universidade Estadual de Londrina, Elena Cantone, University of Queensland - The Diamantina Institute, University of Queensland [Brisbane], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), University College of London [London] (UCL), UC San Diego Health, Karl-Franzens-Universität [Graz, Autriche], Howard University College of Medicine [Washington, DC, USA], Geneva University Hospitals and Geneva University, Cliniques Universitaires Saint-Luc [Bruxelles], Aristotle University of Thessaloniki, Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Stockholm University, University of East Anglia [Norwich] (UEA), Towson University [Towson, MD, United States], University of Maryland System, Severtsov Institute of Ecology and Evolution RAS, University of Padova [Padova, Italy], Biruni University, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospital General de Barrio Obrero [Asunción, Paraguay] (Public Hospital Barrio Obrero ), Private practice [Milan], DreamAir Llc, Oregon State University (OSU), Karolinska Institutet [Stockholm], University of Insubria, Varese, IBM Watson Research Center, IBM, Navarrabiomed-IdiSNA, University of Extremadura, Technische Universität Dresden = Dresden University of Technology (TU Dresden), The Hebrew University of Jerusalem (HUJ), University of Florida [Gainesville] (UF), Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Wageningen University and Research [Wageningen] (WUR), Radboud university [Nijmegen], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Universidad de Chile = University of Chile [Santiago] (UCHILE), Federal University of Technology of Akure (FUTA), University of California [Berkeley], Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), University of Dayton, Iran University of Medical Sciences [Tehran, Iran] (IUMS), 'Federico II' University of Naples Medical School, University of Verona (UNIVR), Xi'an Jiaotong University (Xjtu), Institute of Agrifood Research and Technology (IRTA), University of Alaska [Fairbanks] (UAF), The Hebrew University Medical Center, University of Massachusetts System (UMASS), Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Johns Hopkins University School of Medicine [Baltimore], Institute for Research in Fundamental Sciences [Tehran] (IPM), CSIRO Agriculture and Food (CSIRO), The First Affiliated Hospital of Guangzhou Medical University (GMU), University College Dublin [Dublin] (UCD), Université du Québec à Trois-Rivières (UQTR), Guy’s and St. Thomas’ Hospitals, University of Padova, Kilis Yedi Aralik University, University of Otago [Dunedin, Nouvelle-Zélande], Sancaktepe Education and Research Hospital, University of Pennsylvania [Philadelphia], University of California San Diego Health, Indiana University [Bloomington], Indiana University System, Columbia University Medical Center (CUMC), Columbia University [New York], University of Edinburgh, University of California [Merced], University of Stirling, University of London [London], Florida State University [Tallahassee] (FSU), Université catholique de Bukavu, University of Southern Queensland (USQ), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Technical University of Munich (TUM), University of Graz, Publica, Gerkin, Richard C, Ohla, Kathrin, Veldhuizen, Maria G, Joseph, Paule V, Kelly, Christine E, Bakke, Alyssa J, Steele, Kimberley E, Farruggia, Michael C, Pellegrino, Robert, Pepino, Marta Y, Bouysset, Cédric, Soler, Graciela M, Pereda-Loth, Veronica, Dibattista, Michele, Cooper, Keiland W, Croijmans, Ilja, Di Pizio, Antonella, Ozdener, M Hakan, Fjaeldstad, Alexander W, Lin, Cailu, Sandell, Mari A, Singh, Preet B, Brindha, V Evelyn, Olsson, Shannon B, Saraiva, Luis R, Ahuja, Gaurav, Alwashahi, Mohammed K, Bhutani, Surabhi, D'Errico, Anna, Fornazieri, Marco A, Golebiowski, Jérôme, Hwang, Liang-Dar, Öztürk, Lina, Roura, Eugeni, Spinelli, Sara, Whitcroft, Katherine L, Faraji, Farhoud, Fischmeister, Florian PhS, Heinbockel, Thoma, Hsieh, Julien W, Huart, Caroline, Konstantinidis, Iordani, Menini, Anna, Morini, Gabriella, Olofsson, Jonas K, Philpott, Carl M, Pierron, Deni, Shields, Vonnie D C, Voznessenskaya, Vera V, Albayay, Javier, Altundag, Aytug, Bensafi, Moustafa, Bock, María Adelaida, Calcinoni, Orietta, Fredborg, William, Laudamiel, Christophe, Lim, Juyun, Lundström, Johan N, Macchi, Alberto, Meyer, Pablo, Moein, Shima T, Santamaría, Enrique, Sengupta, Debarka, Dominguez, Paloma Rohlf, Yanik, Hüseyin, Hummel, Thoma, Hayes, John E, Reed, Danielle R, Niv, Masha Y, Munger, Steven D, Parma, Valentina, Tıp Fakültesi, UCL - SSS/IONS/NEUR - Clinical Neuroscience, and UCL - (SLuc) Service d'oto-rhino-laryngologie

Subjects
Male, Multivariate statistics, Physiology, Cross-sectional study, [SDV]Life Sciences [q-bio], coronavirus, Logistic regression, Settore BIO/09 - Fisiologia, Behavioral Neuroscience, 0302 clinical medicine, Hyposmia, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine, 030223 otorhinolaryngology, Sensory Science and Eating Behaviour, Chemosensory, hyposmia, Middle Aged, Prognosis, olfactory, Sensory Systems, Smell, chemosensory, ddc:540, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, HEALTH, medicine.symptom, Adult, medicine.medical_specialty, Anosmia, Coronavirus, Olfactory, Prediction, COVID-19, Cross-Sectional Studies, Humans, SARS-CoV-2, Self Report, 663/664, Visual analogue scale, Odds, 03 medical and health sciences, Physiology (medical), Internal medicine, QUALITY, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, COVID-19 symptoms, Behaviour Change and Well-being, IDENTIFICATION, business.industry, Univariate, prediction, Sensoriek en eetgedrag, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, anosmia, Smell impairment
Abstract

Contains fulltext : 228204.pdf (Publisher’s version ) (Closed access) In a preregistered, cross-sectional study we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC=0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0-10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4

Published
2020

48. Interventional Radiology Obesity Therapeutics: Proceedings from the Society of Interventional Radiology Foundation Research Consensus Panel

Author

Yuan, Frank, primary, Latif, Muhammad A., additional, Shafaat, Omid, additional, Prologo, J. David, additional, Hill, James O., additional, Gudzune, Kimberly A., additional, Marrone, April K., additional, Kraitchman, Dara L., additional, Rogers, Ann M., additional, Khaitan, Leena, additional, Oklu, Rahmi, additional, Pereira, Keith, additional, Steele, Kimberley, additional, White, Sarah B., additional, and Weiss, Clifford R., additional

Published
2021
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