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Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms
- Source :
- IRTA Pubpro. Open Digital Archive, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Chemical senses 46, bjaa081 (2021). doi:10.1093/chemse/bjaa081, Chemical Senses, Chemical Senses, Oxford University Press (OUP), 2021, 46, pp.bjaa081. ⟨10.1093/chemse/bjaa081⟩, Chemical Senses 46 (2020), Chemical Senses, 46, Chemical Senses, 46. Oxford University Press, Gerkin, R C, Ohla, K, Veldhuizen, M G, Joseph, P V, Kelly, C E, Bakke, A J, Steele, K E, Farruggia, M C, Pellegrino, R, Pepino, M Y, Bouysset, C, Soler, G M, Pereda-Loth, V, Dibattista, M, Cooper, K W, Croijmans, I, Di Pizio, A, Ozdener, M H, Fjaeldstad, A W, Lin, C, Sandell, M A, Singh, P B, Brindha, V E, Olsson, S B, Saraiva, L R, Ahuja, G, Alwashahi, M K, Bhutani, S, D'Errico, A, Fornazieri, M A, Golebiowski, J, Hwang, L-D, Öztürk, L, Roura, E, Spinelli, S, Whitcroft, K L, Faraji, F, Fischmeister, F P, Heinbockel, T, Hsieh, J W, Huart, C, Konstantinidis, I, Menini, A, Morini, G, Olofsson, J K, Philpott, C M, Pierron, D, Shields, V D C, Voznessenskaya, V V, Albayay, J & GCCR Group Author 2021, ' Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms ', Chemical Senses, vol. 46, bjaa081 . https://doi.org/10.1093/chemse/bjaa081, Chemical senses, Vol. 46, no.46, p. 1–12 (2021)
- Publication Year :
- 2020
- Publisher :
- Oxford University Press, 2020.
-
Abstract
- Contains fulltext : 228204.pdf (Publisher’s version ) (Closed access) In a preregistered, cross-sectional study we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC=0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0-10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4
- Subjects :
- Male
Multivariate statistics
Physiology
Cross-sectional study
[SDV]Life Sciences [q-bio]
coronavirus
Logistic regression
Settore BIO/09 - Fisiologia
Behavioral Neuroscience
0302 clinical medicine
Hyposmia
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Medicine
030223 otorhinolaryngology
Sensory Science and Eating Behaviour
Chemosensory
hyposmia
Middle Aged
Prognosis
olfactory
Sensory Systems
Smell
chemosensory
ddc:540
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Female
HEALTH
medicine.symptom
Adult
medicine.medical_specialty
Anosmia
Coronavirus
Olfactory
Prediction
COVID-19
Cross-Sectional Studies
Humans
SARS-CoV-2
Self Report
663/664
Visual analogue scale
Odds
03 medical and health sciences
Physiology (medical)
Internal medicine
QUALITY
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
COVID-19 symptoms
Behaviour Change and Well-being
IDENTIFICATION
business.industry
Univariate
prediction
Sensoriek en eetgedrag
business
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
anosmia
Smell impairment
Subjects
Details
- ISSN :
- 0379864X and 14643553
- Database :
- OpenAIRE
- Journal :
- IRTA Pubpro. Open Digital Archive, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Chemical senses 46, bjaa081 (2021). doi:10.1093/chemse/bjaa081, Chemical Senses, Chemical Senses, Oxford University Press (OUP), 2021, 46, pp.bjaa081. ⟨10.1093/chemse/bjaa081⟩, Chemical Senses 46 (2020), Chemical Senses, 46, Chemical Senses, 46. Oxford University Press, Gerkin, R C, Ohla, K, Veldhuizen, M G, Joseph, P V, Kelly, C E, Bakke, A J, Steele, K E, Farruggia, M C, Pellegrino, R, Pepino, M Y, Bouysset, C, Soler, G M, Pereda-Loth, V, Dibattista, M, Cooper, K W, Croijmans, I, Di Pizio, A, Ozdener, M H, Fjaeldstad, A W, Lin, C, Sandell, M A, Singh, P B, Brindha, V E, Olsson, S B, Saraiva, L R, Ahuja, G, Alwashahi, M K, Bhutani, S, D'Errico, A, Fornazieri, M A, Golebiowski, J, Hwang, L-D, Öztürk, L, Roura, E, Spinelli, S, Whitcroft, K L, Faraji, F, Fischmeister, F P, Heinbockel, T, Hsieh, J W, Huart, C, Konstantinidis, I, Menini, A, Morini, G, Olofsson, J K, Philpott, C M, Pierron, D, Shields, V D C, Voznessenskaya, V V, Albayay, J & GCCR Group Author 2021, ' Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms ', Chemical Senses, vol. 46, bjaa081 . https://doi.org/10.1093/chemse/bjaa081, Chemical senses, Vol. 46, no.46, p. 1–12 (2021)
- Accession number :
- edsair.doi.dedup.....bd6c6125978e9c4cf10f4ee274bd0f03