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32 results on '"Sperduti L"'

2. Rigidità arteriosa e fumo

Author

Sperduti, L., LA RUINA, A. 1., Psimenos, A., Mandylakis, E., Terlizzi, R., Valente, L., Pecchiol, V., and Germano', Giuseppe Italo Walter

Published
2009

14. Alexithymia and hypertension

Author

Sperduti, L., Marchetti, P., Ragazzo, F. LINTAS M., Terlizzi, R., LA RUINA, A. I., and Germano', Giuseppe Italo Walter

Published
2005

23. Targeted 'bone-seeking' radiopharmaceuticals for palliative treatment of bone metastases: a systematic review and meta-analysis.

Author

Mantini, Giovanna, D'Angelo, Giorgia, Salvatori, Massimo, Salvatori, M, Sperduti, L, Maini, Cl, Mariani, G., Mantini, Giovanna (ORCID:0000-0001-5303-4499), Sciuto,R (ORCID:0000-0003-0208-1273), Mantini, Giovanna, D'Angelo, Giorgia, Salvatori, Massimo, Salvatori, M, Sperduti, L, Maini, Cl, Mariani, G., Mantini, Giovanna (ORCID:0000-0001-5303-4499), and Sciuto,R (ORCID:0000-0003-0208-1273)

Abstract

AIM: The aim of the study was to assess the state of the art of the use of bone-seeking radiopharmaceuticals for palliation therapy of pain from bone metastases. METHODS: A systematic literature search was conducted about therapy with 89Sr-chloride and 153Sm-EDTMP between 2001-2011. The primary outcomes were efficacy and toxicity. Descriptive and quantitative data were extracted from each study, calculating event rates and odds ratio (OR) with 95% confidence intervals (CI) for pooled analysis. Subgroup analyses were performed. RESULTS: Fifty-seven studies contributed to the systematic review. Forty-six studies used radiopharmaceuticals as a single agent, 15 investigated therapeutic combinations. Most of the studies included patients with prostate cancer. The overall efficacy of bone-seeking radiopharmaceuticals as single agents was 70%, whereas it was 74% when used in combination with other therapies. Complete response was reported in 27% of patients. Efficacy resulted to be 70% for prostate cancer and 79% for breast cancer. The overall toxicity of radiopharmaceuticals was 15%: the toxicity was 11% selecting only studies reporting on the use of radiopharmaceuticals as a single agent. No significant difference was found between bone-seeking radiopharmaceuticals and other oncological treatments regarding efficacy or toxicity. Reports of objective response outcomes suggest that bone-seeking radiopharmaceuticals have some cytotoxic activity, either alone or combination with chemotherapy. CONCLUSION: This literature analysis emphasizes multiple evidences of high efficacy and low toxicity of bone seeking radiopharmaceuticals; moreover, this therapy may have a therapeutic potential beyond simple palliation of bone pain.

Published
2012

26. Arterial Stiffness in Periodontal Disease

Author

Sperduti, L, primary, De Luca, M, additional, Battaglia, F, additional, La Ruina, A I, additional, Mandylakis, E, additional, Marchetti, P, additional, Terlizzi, R, additional, Valente, L, additional, Germanò, G, additional, and Fedele, F, additional

Published
2007
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32. [Relationship between the obstructive sleep apnea syndrome and internal medicine].

Author

Perrone A, Sperduti L, Magliocco C, Marchini C, Masciangelo V, Barbarossa A, Brunori M, and Germanò G

Subjects
Adolescent, Adult, Aged, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Comorbidity, Female, Gastroesophageal Reflux epidemiology, Gastroesophageal Reflux etiology, Humans, Male, Middle Aged, Obesity epidemiology, Polysomnography, Positive-Pressure Respiration, Pulmonary Disease, Chronic Obstructive epidemiology, Risk Factors, Rome epidemiology, Sleep Wake Disorders epidemiology, Surveys and Questionnaires, Internal Medicine, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive epidemiology, Sleep Apnea, Obstructive metabolism, Sleep Apnea, Obstructive physiopathology, Sleep Apnea, Obstructive therapy
Abstract

Twelve to twenty-five percent of human population suffer from sleep disorders and sleep-related breathing disorders have a frequency of 5-10%. The association between sleep-related breathing disorders and several diseases, mainly cardiovascular and dysmetabolic, is well known. The aim of this study was to assess the prevalence of this association in a group of 620 patients, aged between 18 and 78 years and referred to the Laboratory of Respiratory Pathophysiology of the Umberto I Hospital of Rome. All patients had a clinical history of a sleep-related breathing disorder and answered a specific questionnaire. One-hundred-and-thirty-seven patients (120 males and 17 females, mean age 64 years), whose questionnaire was suggestive of a sleep-related breathing disorder, underwent clinical assessment including blood tests, lung function tests, blood-gas analysis, ECG and nocturnal polysomnography, either as in- or as out-patients. The main associated pathologies were: arterial hypertension (54.7%), chronic obstructive pulmonary disease (17.9%), obesity (63.1%), dyslipidemia (41%), type 2 diabetes mellitus (6.3%), gastroesophageal reflux (27.3%) and cardiac arrhythmias (4.2%); 95 patients with obstructive sleep apnea syndrome were treated, on the basis of the polysomnography outcomes and according to the Italian Association of Sleep Medicine Guidelines, either with preventive strategies for risk factor reduction, or with medical (positive pressure ventilation, oxygen, assessment of the best drug medication) and/or ear, nose end throat surgical therapies. In most patients, the improvement in the sleep-related breathing disorder was associated with an improvement in their systemic pathology, in particular cardiovascular disease, suggesting the need of a deeper consideration and comprehension of nocturnal apneas.

Published
2004

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