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Background: The prevalence of metabolic syndrome is high and is increasing in parallel with increasing incidences of breast and prostate cancers. The combination of soy with tea was shown to have synergistic effects on preventing breast and prostate tumors, but the effects of soy and tea combinations on metabolic syndrome-related elements have not been investigated. Objective: We aimed to determine the effects of soy and tea components, alone and in combination, on abdominal adipose mass and serum concentrations of adipokines, growth factors, and sex hormones in male and female mice. Design: Male and female FVB/N mice were treated with soy, tea components, or both. Food intake and body weight were monitored weekly. At the end of the experiment, abdominal white adipose tissue was weighed, and serum concentrations of biomarkers were measured. Results: Whole teas, but not the tea polyphenol extracts, significantly reduced abdominal white adipose tissue by 43-60% in female mice and by 65-70% in male mice. The combination of soy phyto-chemical concentrate and green tea reduced serum insulin-like growth factor-I concentrations in both male and female mice in a synergistic manner. The soy phytochemical concentrate and tea combinations reduced serum estrogen concentrations in female mice in a synergistic manner. Soy phytochemical concentrate and teas also significantly reduced serum leptin concentrations in both male and female mice and testosterone concentrations in male mice. Conclusion: Further research is warranted to investigate whether soy and tea combinations may prevent breast or prostate cancer in a synergistic manner in part by alleviating metabolic disorders. KEY WORDS Metabolic syndrome, cancer prevention, tea, soy, insulin-like growth factor-I, IGF-I, leptin, synergy

Soy is a legume from the family Fabaceae. In many countries it is one of the most important food crop. Soyabean is the seed obtained from the pod of the plant and is classified as oilseeds. It is rich in protein carbohydrates, saponins, phytiacid and oil but has lower levels of calcium. It has wide range of therapeutic as well as pharmaceutical applications. It has sedative, anti-spasmodic, diaphoretic, anti-pyretic properties, with hormonal balancing effects, can be used to prevent breast cancer, prostate cancer, endometrial cancer and baldness and has great benefit to the liver and circulation. It acts as a component of easy release jelly and also as an agent that provides good hardness and disintegrating property. It has application in sunscreen cream, moisturizing cream, and anti-wrinkle cream. Although it has many advantages and use but it is not without risk such as it can increase the rate of tumor growth in persons already suffering from cancer. Keywords: Soy | Therapeutic use | pharmaceutical use | cosmetic use | health risks., Introduction Soy is believed to be derived from Glycine ussuriensis, a legumes that performs nitrogen fixation symbiotically. It is from Kingdom: Plantae, Phylum: Magnoliophyta, Class Magnoliopsida, Order: Fables, Family: Fabaceae, [...]