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Your search keyword '"Sosulina LIu"' showing total 5 results
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5 results on '"Sosulina LIu"'

1. [ADP-ribose and cADP-ribose--endogenous regulators of cellular ionic balance. Cardiotropic effects of ADP-ribose].

Author

Kuz'min VS, Sosulina LIu, Sukhova GS, and Ashmarin IP

Subjects
Adenosine Diphosphate Ribose metabolism, Adenosine Diphosphate Ribose pharmacology, Animals, Cyclic ADP-Ribose metabolism, Cyclic ADP-Ribose pharmacology, Cyclic ADP-Ribose physiology, Heart physiology, Humans, Myocardial Contraction drug effects, Potassium Channels metabolism, Receptors, Purinergic metabolism, Adenosine Diphosphate Ribose physiology, Calcium metabolism, Heart drug effects, Myocardium metabolism
Abstract

Functions and possible mechanisms of action of adenosine diphosphate ribose (ADP-ribose) and its cyclic analogue--cycle-ADP-ribose (cADP-ribose)-- substances pretend to role of novel second messengers are reviewed. Possible mechanisms of ADP-ribose and cADP-ribose synthesis regulation and metabolism are analyzed. Prospective mechanisms of ADP-ribose and cADP-ribose transportation into the cell are described. ADP-ribose and cADP-ribose are considered as endogenous regulators of ionic balance (in particular regulators of calcium balance) in different tissues. Effects of ADP-ribose on isolated heart of frog and warm-blooded animal (rat), as well as on rat heart in vivo are discussed. The role of ionic channels and receptors, gated by ADP- and cADP-ribose in regulation of cardiomyocyte ionic balance in normal and pathological condition are analyzed. The possible role of purine receptors in ADP-ribose and cADP-ribose effects on heart are discussed.

Published
2006

2. [TSKY peptide inhibits the ground squirrel recovery after hibernation].

Author

Ignat'ev DA, Mikhaleva II, Sosulina LIu, Zakarian AA, Sukhova GS, and Ziganshin RKh

Subjects
Animals, Depression, Chemical, Endorphins pharmacology, Heart Rate, Hibernation physiology, In Vitro Techniques, Peptide Fragments pharmacology, Ranidae, Sciuridae, Endorphins physiology, Hibernation drug effects, Peptide Fragments physiology
Published
2001

3. [The action of ADP ribose on the mechanical and bioelectrical activity of the frog heart].

Author

Sosulina LIu, Sukhova GS, Chudnyĭ MN, and Ashmarin IP

Subjects
Adenosine Monophosphate pharmacology, Animals, Dose-Response Relationship, Drug, Electrocardiography drug effects, Electrocardiography statistics & numerical data, Electrophysiology, Heart physiology, In Vitro Techniques, Myocardial Contraction physiology, Rana temporaria, Signal Processing, Computer-Assisted, Statistics, Nonparametric, Adenosine Diphosphate Ribose pharmacology, Heart drug effects, Myocardial Contraction drug effects
Abstract

In the frog isolated heart, cyclic perfusion of ADP-ribose induced a dose-dependent decrease in the heart rate and the contraction force, a decrease in the AP duration as well as in the rate of rise in the sinus node. It also shortened the atrial AP and exerted no significant effect upon multicellular ventricular preparations. In conditions of systemic administration in unanesthetised frogs, the ADP-ribose induced a reversible increase in the heart rate due, probably, to a sympathetic effect.

Published
1999

4. [The cardiotropic activity of the nucleotides found in the composition of the low-molecular peptide subfraction obtained from the brain of hibernating susliks Citellus undulatus].

Author

Liashkov AE, Neguliaev OV, Sosulina LIu, Ziganshin RKh, Mikhaleva II, and Sukhova GS

Subjects
Adenosine Monophosphate pharmacology, Animals, Cardiovascular Agents isolation & purification, Guanosine Monophosphate pharmacology, In Vitro Techniques, Molecular Weight, Myocardial Contraction drug effects, Myocardial Contraction physiology, Nucleotides isolation & purification, Peptides isolation & purification, Rana temporaria, Statistics, Nonparametric, Brain Chemistry physiology, Cardiovascular Agents pharmacology, Hibernation physiology, Nucleotides pharmacology, Peptides pharmacology, Sciuridae physiology
Published
1999

5. [Participation of 5'-AMP in cardiotropic effect of tissue extracts from hibernating animals].

Author

Sukhova GS, Sosulina LIu, Neguliaev OV, Ziganshin RKh, and Mikhaleva II

Subjects
Adenosine Monophosphate pharmacology, Animals, Electrophysiology, Heart physiology, Heart Rate drug effects, In Vitro Techniques, Microelectrodes, Molecular Weight, Myocardial Contraction drug effects, Peptides chemistry, Peptides isolation & purification, Rana temporaria, Sciuridae, Adenosine Monophosphate physiology, Brain metabolism, Heart drug effects, Hibernation, Peptides pharmacology, Tissue Extracts chemistry
Published
1998

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