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[ADP-ribose and cADP-ribose--endogenous regulators of cellular ionic balance. Cardiotropic effects of ADP-ribose].
- Source :
-
Uspekhi fiziologicheskikh nauk [Usp Fiziol Nauk] 2006 Jan-Mar; Vol. 37 (1), pp. 3-17. - Publication Year :
- 2006
-
Abstract
- Functions and possible mechanisms of action of adenosine diphosphate ribose (ADP-ribose) and its cyclic analogue--cycle-ADP-ribose (cADP-ribose)-- substances pretend to role of novel second messengers are reviewed. Possible mechanisms of ADP-ribose and cADP-ribose synthesis regulation and metabolism are analyzed. Prospective mechanisms of ADP-ribose and cADP-ribose transportation into the cell are described. ADP-ribose and cADP-ribose are considered as endogenous regulators of ionic balance (in particular regulators of calcium balance) in different tissues. Effects of ADP-ribose on isolated heart of frog and warm-blooded animal (rat), as well as on rat heart in vivo are discussed. The role of ionic channels and receptors, gated by ADP- and cADP-ribose in regulation of cardiomyocyte ionic balance in normal and pathological condition are analyzed. The possible role of purine receptors in ADP-ribose and cADP-ribose effects on heart are discussed.
- Subjects :
- Adenosine Diphosphate Ribose metabolism
Adenosine Diphosphate Ribose pharmacology
Animals
Cyclic ADP-Ribose metabolism
Cyclic ADP-Ribose pharmacology
Cyclic ADP-Ribose physiology
Heart physiology
Humans
Myocardial Contraction drug effects
Potassium Channels metabolism
Receptors, Purinergic metabolism
Adenosine Diphosphate Ribose physiology
Calcium metabolism
Heart drug effects
Myocardium metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0301-1798
- Volume :
- 37
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Uspekhi fiziologicheskikh nauk
- Publication Type :
- Academic Journal
- Accession number :
- 16522000