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As a new type of anti-cancer therapy, immune checkpoint inhibitors (ICIs) have transformed the treatment of various cancers. However, ICIs are associated with many potential complications, namely immune-related adverse events (irAEs) , possibly involving the nervous, cardiac, pulmonary, cutaneous, renal, gastrointestinal, hepatic, and hematologic systems. Although a series of guidelines for the management of irAEs have been issued, early identification, diagnosis and treatment of irAEs in clinical practice are still not standardized enough due to different levels of awareness and attention regarding the disease across clinicians. We analyzed the clinical data of a patient with severe multisystem irAEs developed after treatment with cindilimab, and reviewed relevant literature, then summarized the benefits and limitations of treatments for irAEs, providing ideas for better managing multisystem irAEs clinically.

Radiative cooling films (RCFs) are crucial for spacecraft thermal management, but their optical performance is currently limited by their structures and intrinsic high absorption at short wavelengths. In this study, a novel RCF using electrospun polyimide nanofibers optimized at both the molecular and microscale levels is developed. The newly designed polyimide molecules significantly decrease visible and ultraviolet (UV) light absorption while maintaining excellent thermal radiation properties in the infrared spectrum. By optimizing the diameter and orientation of the nanofibers using Monte Carlo simulations, the resulting film achieves a solar reflectivity of 99.6% and a mid‐infrared emissivity of 0.93. Its physical structures and optical properties remain stable under exposure to UV light, atomic oxygen, and extreme temperature changes. Further vacuum radiative cooling tests reveal that the thermal equilibrium temperature of this film is approximately 28 °C lower than that of Kapton‐based RCFs currently used in spacecraft. These results provide a new approach for creating efficient thermal management materials for space applications, with potential for broader use in architecture, electronic devices, and outdoor equipment. [ABSTRACT FROM AUTHOR]

CuO/CNT/Bi2WO6 composites were synthesized with a solvothermal and impregnation-calcination method. This material combines the advantages of CuO, carbon nanotubes (CNTs) and Bi2WO6. The photocatalytic activity of the catalyst was evaluated by degrading phenolic organic pollutants such as p-nitrophenol and phenol under visible light. Compared with pure Bi2WO6, the photocatalytic activity of CuO/CNT/Bi2WO6 composites is significantly increased by a factor of 3.52. The main reason for the increased activity is that the doped CNTs and CuO promote the separation of photogenerated hole and electron pairs. In addition, the coupling of π-π electrons on the CNT surface with the pollutants promotes the adsorption of the pollutants on the photocatalyst surface. The degradation rate of pure photocatalytic degradation of phenol can reach 60%. Under the synergistic effect of H2O2, the degradation rate of phenol can reach 94%, which is 1.56 times higher than that of pure photocatalysis. The UV–vis absorption spectrum shows that CuO/CNT/Bi2WO6 has stronger light absorption ability in both visible and ultraviolet light regions. The trapping experiments of active species show that h + and • OH are the main active substances for photocatalytic degradation of phenol. This paper proposes a Z scheme mechanism to improve the photocatalytic performance. [ABSTRACT FROM AUTHOR]

Lipopolysaccharide (LPS) is an important stimulus of inflammation via binding to toll-like receptor 4 (TLR4), but the role of TLR4 in LPS-induced cellular homeostasis disruption indicated by the increased level of endoplasmic reticulum (ER) stress, autophagy, and apoptosis is unknown in the liver of dairy cows. Previous studies show that forkhead box protein A2 (FOXA2) is an important transcriptional factor to maintain cellular metabolic homeostasis, but the mechanisms by which FOXA2 mediates cellular homeostasis disruption in response to LPS remains unclear. To achieve the aims, hepatocytes separated from dairy cows at ∼160 d in milk were pretreated with a specific TLR4 inhibitor TAK-242 for 12 h, followed by LPS treatment for another 12 h to investigate the role of TLR4 in LPS-induced disruption of cellular homeostasis. The results indicated that LPS-induced nuclear factor-κB (NF-κB)-mediated inflammatory cascades, ER stress, autophagy, and apoptosis via activating TLR4 and downregulating FOXA2 expression in bovine hepatocytes. The application of TLR4 inhibitor alleviated LPS-induced inflammation through inactivating NF-κB proinflammatory pathway, restored cell homeostasis by decreasing the level of ER stress, autophagy, and apoptosis, and upregulated FOXA2 expression. Furthermore, we also elevated FOXA2 expression with an overexpression plasmid to clarify its molecular role in response to LPS challenge. FOXA2 overexpression reduced LPS-caused inflammation by inhibiting NF-κB signaling pathway. Also, FOXA2 could alleviate ER stress to block unfolded protein response and suppress autophagic flux. In addition, FOXA2 enhanced mitochondrial membrane potential via reducing pro-apoptotic protein BAX, CASPASE3, and Cleaved CASPASE3 expression and elevating anti-apoptotic protein BCL-2 expression to mitigate LPS-induced apoptosis. Taken together, these findings suggested that FOXA2 is a mediator to alleviate TLR4-controlled inflammation, ER stress, autophagy, and apoptosis in LPS-treated bovine hepatocytes, it could serve as a potential target to intervene cell homeostasis disruption caused by LPS in the liver of dairy cows. [ABSTRACT FROM AUTHOR]

CuO/CNT/Bi 2 WO 6 composites were synthesized with a solvothermal and impregnation-calcination method. This material combines the advantages of CuO, carbon nanotubes (CNTs) and Bi 2 WO 6 . The photocatalytic activity of the catalyst was evaluated by degrading phenolic organic pollutants such as p-nitrophenol and phenol under visible light. Compared with pure Bi 2 WO 6 , the photocatalytic activity of CuO/CNT/Bi 2 WO 6 composites is significantly increased by a factor of 3.52. The main reason for the increased activity is that the doped CNTs and CuO promote the separation of photogenerated hole and electron pairs. In addition, the coupling of π-π electrons on the CNT surface with the pollutants promotes the adsorption of the pollutants on the photocatalyst surface. The degradation rate of pure photocatalytic degradation of phenol can reach 60%. Under the synergistic effect of H 2 O 2 , the degradation rate of phenol can reach 94%, which is 1.56 times higher than that of pure photocatalysis. The UV-vis absorption spectrum shows that CuO/CNT/Bi 2 WO 6 has stronger light absorption ability in both visible and ultraviolet light regions. The trapping experiments of active species show that h + and • OH are the main active substances for photocatalytic degradation of phenol. This paper proposes a Z scheme mechanism to improve the photocatalytic performance.