1. Trends in Bone Marrow Sampling and Core Biopsy Specimen Adequacy in the United States and Canada
- Author
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Michel R. Nasr, Neerja Vajpayee, Alan D. Hutson, Michael R. Lewis, Claudiu V. Cotta, James E. Coad, Gregory E. Wilding, Kieran Sultan, Sinisa Ivelja, John T Grantham, Richard Cheney, Gratian Salaru, Mihai Merzianu, Guilherme Brandao, Prabhjot Kaur, Valentin G. Robu, Shanxiang Zhang, John Lazarchick, Attilio Orazi, Sindhu Cherian, LoAnn Peterson, Ling Zhang, Robert W. McKenna, Jerome B. Myers, Jeffrey A. Vos, Ridas Juskevicius, Elizabeth L. Courville, Adrienne Groman, Rodney R. Miles, Elisa Brega, Robert E. Hutchison, David D. Grier, Vishnu Reddy, Daniela Hoehn, Guang Fan, Russell K. Brynes, Manjula Balasubramanian, Horatiu Olteanu, Ramila Amre, Julie Teruya-Feldstein, Kedar V. Inamdar, Hina Naushad Qureishi, David R. Czuchlewski, and Le Aye
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,Cross-sectional study ,business.industry ,Retrospective cohort study ,General Medicine ,Bone marrow examination ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Multicenter study ,030220 oncology & carcinogenesis ,Biopsy ,Medicine ,Bone marrow sampling ,Radiology ,Bone marrow ,business ,Core biopsy ,030215 immunology - Abstract
Objectives To assess bone marrow (BM) sampling in academic medical centers. Methods Data from 6,374 BM samples obtained in 32 centers in 2001 and 2011, including core length (CL), were analyzed. Results BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) specimen, or both (83%). The median (SD) CL was 12 (8.5) mm, and evaluable marrow was 9 (7.6) mm. Tissue contraction due to processing was 15%. BMB specimens were longer in adults younger than 60 years, men, and bilateral, staging, and baseline samples. Only 4% of BMB and 2% of BMB/BMA samples were deemed inadequate for diagnosis. BM for plasma cell dyscrasias, nonphysician operators, and ancillary studies usage increased, while bilateral sampling decreased over the decade. BM-related quality assurance programs are infrequent. Conclusions CL is shorter than recommended and varies with patient age and sex, clinical circumstances, and center experience. While pathologists render diagnoses on most cases irrespective of CL, BMB yield improvement is desirable.
- Published
- 2018