4 results on '"Simaan F"'
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2. Some Further Observations on Goiter in Lebanon
- Author
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COWAN, J. W., NAJJAR, S. S., SABRY, Z. I., TANNOUS, R. I., and SIMAAN, F. S.
- Abstract
An incidence of goiter of 25.4 per cent was found among school children residing in a mountain village in Lebanon. This incidence was highest in girls between nine and twelve years of age; the incidence appeared to be related to socioeconomic status.Twenty-six families from the area were Selected to participate in a double-blind controlled salt supplementation program. For twelve months, half the families were given iodized salt and the other half plain salt. Clinical examinations were conducted and the urinary excretion of iodine was measured initially and at intervals through the study. In the group given iodized salt, the incidence of goiter decreased from 30 to 12 per cent, whereas in the control group there was a decrease from 41 to 36 per cent. Initial values for urinary iodine were low in all subjects of both groups; after the distribution of salt, excretion values increased significantly in the group given supplements.Studies of the thyroidal uptake of Il31showed high values in subjects with and without goiters in the control group; the mean values for the group given iodized salt were greatly decreased. The results of a thiocyanate test in a group of subjects with goiters were negative.Dietary information failed to reveal an unusually high consumption of goitrogenic foods. However, high salt intake was observed; this observation was supported by the finding, in general, of high levels of urinary chloride. The possible relationship of high salt intake to goiter in human subjects was examined, based on information from experiments with animals.It was concluded that iodine deficiency was the primary cause of goiter in the area in which the study was conducted. Other factors which may have contributed to the local problem of goiter are discussed.
- Published
- 1965
- Full Text
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3. Anterior Chamber Intraocular Lens Implantation Versus Four-Flanged Scleral Fixation Technique for Patients With Loss of Capsular Support During Routine Cataract Surgery.
- Author
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Dubinsky-Pertzov B, Mahler O, Shemer A, Hecht I, Simaan F, Belkin A, Pras E, and Einan-Lifshitz A
- Subjects
- Humans, Retrospective Studies, Female, Male, Aged, Middle Aged, Postoperative Complications, Suture Techniques, Follow-Up Studies, Intraocular Pressure physiology, Lenses, Intraocular, Cataract Extraction methods, Phacoemulsification methods, Aged, 80 and over, Lens Capsule, Crystalline surgery, Pseudophakia physiopathology, Lens Implantation, Intraocular methods, Sclera surgery, Visual Acuity physiology, Anterior Chamber surgery
- Abstract
Purpose: To compare the outcomes of anterior chamber intraocular lens (AC-IOL) implantation versus the four-flanged scleral fixation technique in eyes with loss of capsular support during routine cataract surgery., Methods: This was a retrospective cohort study of all patients in whom an IOL was implanted either during or after short-term aphakia due to loss of capsular and sulcus support in a routine cataract surgery with at least 6 months of follow-up time between 2015 and 2023 in a tertiary medical center in Israel. Two different IOL implantation techniques were compared: the implantation of an angle-supported ACIOL and four-flanged scleral fixation. Main outcome measures included postoperative complications such as pseudophakic bullous keratopathy, loss of intraocular pressure control and glaucoma, IOL subluxation, and retinal detachment., Results: Sixty-five eyes of 65 patients were included in the study, 33 eyes in the AC-IOL group and 32 eyes in the flange group. Follow-up time was 29.92 ± 20.02 months in the AC-IOL group and 20.17 ± 15.56 months in the flange group ( P = .087). Pseudophakic bullous keratopathy was observed in 10 (30.3%) patients in the AC-IOL group and in 1 (3.1%) patient in the flange group ( P = .04). This association remained significant using survival analysis ( P = .006). In 4 (12.1%) patients in the AC-IOL group, a glaucoma filtering procedure was performed to control the intraocular pressure compared with none in the flange group ( P = .042)., Conclusions: In the setting of loss of capsular support during routine cataract surgery, four-flanged scleral fixation showed an overall lower rate of complications and significantly reduced rate of subsequent surgical interventions. [ J Refract Surg . 2024;40(8):e520-e526.] .
- Published
- 2024
- Full Text
- View/download PDF
4. Best Disease: Global Mutations Review, Genotype-Phenotype Correlation, and Prevalence Analysis in the Israeli Population.
- Author
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Beryozkin A, Sher I, Ehrenberg M, Zur D, Newman H, Gradstein L, Simaan F, Rotenstreich Y, Goldenberg-Cohen N, Bahar I, Blumenfeld A, Rivera A, Rosin B, Deitch-Harel I, Perlman I, Mechoulam H, Chowers I, Leibu R, Ben-Yosef T, Pras E, Banin E, Sharon D, and Khateb S
- Subjects
- Humans, Israel epidemiology, Prevalence, Mutation, Genetic Association Studies, Bestrophins, Vitelliform Macular Dystrophy
- Abstract
Purpose: To review all reported disease-causing mutations in BEST1, perform genotype-phenotype correlation, and estimate disease prevalence in the Israeli population., Methods: Medical records of patients diagnosed with Best disease and allied diseases from nine Israeli medical centers over the past 20 years were collected, as were clinical data including ocular findings, electrophysiology results, and retina imaging. Mutation detection involved mainly whole exome sequencing and candidate gene analysis. Demographic data were obtained from the Israeli Bureau of Statistics (January 2023). A bibliometric study was also conducted to gather mutation data from online sources., Results: A total of 134 patients were clinically diagnosed with Best disease and related conditions. The estimated prevalence of Best disease was calculated to be 1 in 127,000, with higher rates among Arab Muslims (1 in 76,000) than Jews (1 in 145,000). Genetic causes were identified in 76 individuals (57%), primarily showing autosomal-dominant inheritance due to BEST1 mutations (58 patients). Critical conserved domains were identified consisting of a high percentage of dominant missense mutations, primarily in transmembrane domains and the intracellular region (Ca2+ binding domain) of the BEST1 protein., Conclusions: This study represents the largest cohort of patients with Best disease reported in Israel and globally. The prevalence in Israel is akin to that in Denmark but is lower than that in the United States. Critical conserved domains within the BEST1 protein are pivotal for normal functioning, and even minor missense alterations in these areas lead to a dominant disease manifestation. Genetic testing is indispensable as the gold standard for Best disease diagnosis due to the variable clinical presentation of the disease.
- Published
- 2024
- Full Text
- View/download PDF
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