231 results on '"Silva NC"'
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2. Challenges in biotechnology of reproduction in dairy cattle: the antral follicle counting as a fertility parameter
- Author
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Zangirolamo AF, da Silva NC, Búfalo I, and Seneda MM
- Subjects
Bovine ,Dairy cattle ,Antral follicle counting ,Reproductive biotechnics ,Reproduction ,QH471-489 ,Zoology ,QL1-991 - Abstract
Dairy farming plays an important role in the socioeconomic scenario, and several characteristics point to an enormous potential for growth in the productivity of the herd. This is a complex activity that needs to be carried out efficiently in all the links that integrate it. Moreover, due to the physiological and metabolic aspects of the animals with the aptitude for the milk production, several challenges arise, especially in the reproductive scope. In this context, breeding biotechniques appear as a good alternative to the increase in reproductive rates and genetic improvement of dairy cattle. In addition, ovarian antral follicle counts (AFC) have been studied as a way to improve the selection of females to compose reproductive programs, because it has been shown to be a factor of high repeatability over the reproductive life in the same animal. Although studies have shown controversial results regarding the relationship between AFC and fertility, it is still necessary to investigate the possible variables that may interfere with the performance of donors in each biotechnology used. Thus, this review intends to gather and discuss the relationship of AFC with physiological aspects of dairy cows, its application as a parameter of selection of animals with good fertility and, the challenges for the application of reproductive biotechniques in dairy cattle.
- Published
- 2017
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3. Production of neutron-rich isotopes from the fragmentation of 28Si projectiles at plab=14.6 GeV/c per nucleon
- Author
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Barrette, Bellwied, Braun-Munzinger, Cleland, David, Dee, Dietzsch, Duek, Fatyga, Fox, Greene, Hall, Hemmick, Herrmann, Hong, Jayananda, Kraus, Kumar, Lacasse, Lissauer, Llope, Ludlam, Mark, McCorkle, Mitchell, Muthuswamy, O'Brien, Pruneau, Rotondo, da Silva NC, Simon-Gillo, Sonnadara, Stachel, Takagui, Takai, Throwe, Waters, Winter, Wolf, Wolfe, Woody, Zhang, and Zou
- Published
- 1995
4. ATLAS computing technical proposal
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ATLAS Collaboration, Airapetian, A, Grabsky, V, Hakopian, H, Vartapetian, A, Fares, F, Moorhead, GF, Sevior, ME, Taylor, GN, Tovey, SN, Alexiev, D, Donnelly, IJ, Varvell, KE, Williams, ML, Hashemi-Nezhad, R, Peak, L, Saavedra, A, Ulrichs, J, Girtler, P, Kiener, C, Kneringer, E, Kuhn, D, Rudolph, G, Abdinov, OB, Aliev, FM, Khalilzade, FT, Mehdiyev, RR, Rzaev, HJ, Usubov, ZU, Baturitsky, MA, Bogush, AA, Demchenko, AI, Gazizov, AZ, Gilevsky, VV, Golubev, VS, Levchuk, MI, Satsunkevich, IS, Shevtsov, VV, Caloba, LP, Galvez-Durand, F, Maidantchik, CL, Marroquin, F, Seixas, JM, Thome, ZD, da Silva, NC, Dietzsch, O, Leite, MAL, Sakanoue, MH, Takagui, EM, Zandona, F, Armstrong, WW, Burris, W, Gingrich, DM, Hewlett, JC, Holm, L, Mullin, S, Pinfold, JL, Schaapman, J, Soukup, J, Wampler, L, Axen, D, Mayer, JK, Orr, RS, Armitage, J, Dixit, M, Dubeau, J, Estabrooks, P, Losty, M, Neuheimer, E, O'Neill, M, Oakham, G, Azuelos, G, Ben El Fassi, A, Depommier, P, Leon-Florian, E, Leroy, C, Lorazo, B, Martin, JP, Marullo, F, Roy, P, Savard, P, Bailey, DC, Bhadra, S, Martin, JF, Sinervo, PK, Stairs, GG, Trischuk, W, Astbury, A, Birney, P, Hodges, T, Langstaff, R, Oram, C, Roberts, B, Rosvick, M, Wellisch, HP, Bishop, S, Fincke-Keeler, M, Honma, A, Keeler, R, Lefebvre, M, O'Neil, D, Poffenberger, P, Robertson, L, Roney, M, Sobie, R, Akesson, T, Anghinolfi, F, Bachy, G, Barberio, E, Benincasa, G, Bergsma, F, Bjorset, L, Blocki, J, Bloess, D, Bock, R, Bogaerts, J, Brawn, I, Burckhart, HJ, Butin, F, Campbell, M, Chesi, E, Chevalley, JL, Christiansen, J, Cobal, M, Dabrowski, W, Dauvergne, JP, Dell'Acqua, A, Denes, E, Dittus, F, Dobinson, R, Drakoulakos, D, Dufey, JP, Eerola, P, Efthymiopoulos, I, Ellis, N, Fabjan, CW, Farthouat, P, Flegel, W, Francis, D, Froidevaux, D, Gebart, R, Gianotti, F, Gildemeister, O, Hatch, M, Haug, F, Hauviller, C, Heeley, R, Heijne, E, Henriques, A, Hoffmann, HF, Hortnagl, C, Jarp, S, Jarron, P, Jenni, P, Jones, R, Kantardjian, G, Kaplon, J, Klempt, W, Klyuchnikova, T, Knobloch, J, Koski, K, Kotz, U, Lacasta, C, Langhans, W, Lasseur, C, Lehraus, I, Lemeilleur, F, Lichard, P, Liebhart, M, Linde, F, Lofstedt, B, Madsen, N, Mapelli, L, Marchioro, A, Martin, B, Maugin, JM, McLaren, RA, Meier, D, Michelotto, M, Mornacchi, G, Myers, D, Nessi, M, Nicquevert, B, Onions, C, Patel, A, Poggioli, L, Poppleton, A, Posch, C, Poulard, G, Price, M, Riedler, P, Riegler, W, Roe, S, Rohrbach, F, Rosso, E, Rudge, A, Ryzhov, V, Schaller, M, Schmid, P, Schmitt, M, Schuler, G, Snoeys, W, Spegel, M, Spiwoks, R, Stavrianakou, M, Stavropoulos, G, Tartarelli, F, Taylor, B, ten Kate, H, Treichel, M, Tsesmelis, E, van der Bij, H, Vasey, F, von Boehn-Bucholz, R, Voss, R, Vreeswijk, M, Vuillemin, V, Weilhammer, P, Wendler, H, Werner, P, Witzeling, W, Wotschack, J, Bohm, J, Hrivnac, J, Lednicky, R, Lokajicek, M, Nemecek, S, Sicho, P, Simak, V, Stastny, J, Stedron, M, Vanickova, M, Vrba, V, Davidek, T, Dolejsi, J, Dolezal, Z, Kucera, M, Leitner, R, Soustruznik, K, 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Dargent, P, Delpierre, P, Dinkespiler, B, Duval, PY, Etienne, F, Fallou, A, Fassnacht, P, Ferrato, D, Fouchez, D, Gally, Y, Grigorev, E, Habrard, MC, Hallewell, G, Le Van Suu, A, Martin, L, Mekkaoui, A, Monnier, E, Mouthuy, T, Nacasch, R, Nagy, E, Olivetto, C, Pouit, L, Qian, Z, Raymond, M, Rondot, C, Rozanov, AN, Sauvage, D, Tisserant, S, Touchard, F, Vacavant, L, Ardelean, J, Arnault, C, Auge, E, Barrand, G, Belot, G, Bouchel, M, Boucrot, J, Breton, D, Chollet, C, Coulon, JP, de la Taille, C, Delebecque, P, Ducorps, A, Fayard, L, Fournier, D, Gonzales, J, Grivaz, JF, Hrisoho, A, Iconomidou-Fayard, L, Imbert, P, Jacquier, Y, Jean, P, Lavigne, B, Mace, G, Martin-Chassard, G, Merkel, B, Nikolic, I, Noppe, JM, Parrour, G, Petroff, P, Puzo, P, Richer, JP, Schaffer, AC, Seguin-Moreau, N, Serin, L, Tisserand, V, Togat, V, Unal, G, Vales, F, Veillet, JJ, Vernay, E, Alexanian, H, Baubillier, M, Bezamat, J, Billoir, P, Blouzon, F, Canton, B, David, J, Genat, J F, Imbault, D, Le Dortz, O, 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Liparteliani, A, Metreveli, Z, Mosidze, M, Salukvadze, R, Desch, K, Fischer, P, Geich-Gimbel, C, Hilger, E, Meuser, S, Ockenfels, W, Raith, B, Wermes, N, Becker, C, Fuss, J, Gossling, C, Lisowski, B, Luthaus, P, Wunstorf, R, Bar, T, Chen, J, Ebling, DG, Goppert, R, Herten, G, Irsigler, R, Kollefrath, M, Kolpin, R, Landgraf, U, Lauxtermann, S, Ludwig, J, Mohr, W, Paschhoff, V, Rehmann, V, Rolker, B, Runge, K, Schafer, F, Scherberger, G, Schmid, T, Webel, M, Weber, C, Geweniger, C, Hanke, P, Kluge, EE, Mass, A, Putzer, A, Tittel, K, Wunsch, M, Doersing, V, Erhard, W, Kammel, P, Reinsch, A, Buchholz, P, Hoelldorfer, F, Jakobs, K, Kleinknecht, K, Kopke, L, Marschalkowski, E, Merle, K, Othegraven, R, Renk, B, Schafer, U, Schue, Y, Walkowiak, W, Hoegl, H, Kugel, A, Ludvig, J, Manner, R, Noffz, KH, Ruehl, S, Zoz, R, Deile, M, Dubbert, J, Faessler, MA, Hessey, NP, Sammer, T, Staude, A, Trefzger, T, Ackermann, K, Aderholz, M, Andricek, L, Blum, W, Bratzler, U, Brettel, H, Dietl, H, Dulny, B, 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P, Heubers, W, Kaan, B, Kieft, GNM, Kluit, R, Massaro, GGG, Meddeler, G, Metselaar, J, Rewiersma, PAM, Schuijlenburg, H, Spelt, J, Vermeulen, JC, Werneke, P, Woudstra, M, van Eijk, B, van der Graaf, H, Bergman, R, Brouwer, C, Crijns, FJGH, Dijkema, JA, Kittel, W, Klok, PF, Konig, AC, Metzger, WJ, Pols, CLA, Schotanus, DJ, Visser, EJ, Wijnen, TAM, Chakir, H, Cherkaoui, R, Hoummada, A, Saidi, H, Sayouty, E, Eigen, G, Frodesen, AG, Klovning, A, Stugu, B, Bugge, L, Buran, T, Kristiansen, H, Nygard, E, Stapnes, S, Gadomski, S, Godlewski, J, Hajduk, Z, Kisielewski, B, Korcyl, K, Malecki, P, Moszczynski, A, Olszowska, J, Richter-Was, E, Sobala, A, Grybos, P, Idzik, M, Jagielski, S, Jelen, K, Kisielewska, D, Kowalski, T, Rulikowska-Zarebska, E, Amaral, P, Amorim, A, Carvalho, J, Casarejos, E, David, M, Gomes, A, Gomes, J, Ivanyushenkov, Yu, Maio, A, Maneira, M, Martins, JP, Onofre, A, Pinhao, J, Santos, J, Silva, J, Varandas, M, Wolters, H, Arsenescu, R, Boldea, V, Caprini, I, Caprini, M, Constantin, F, Constantinescu, S, Dita, P, Dita, S, Legrand, IC, Maniu, G, Micu, L, Niculescu, M, Pantea, D, Popeneciu, G, Serban, T, Artamonov, A, Epstein, V, Gorbunov, P, Gurin, R, Zhemanov, V, Khovansky, V, Kuchenkov, A, Kruchinin, S, Maslennikov, A, Ryabinin, M, Shatalov, P, Tsukerman, I, Zaitsev, V, Zeldovich, S, Akimov, A, Baranov, SP, Belov, M, Blagov, M, Gavrilenko, I, Komar, A, Konovalov, S, Kopytin, M, Muravev, S, Popov, L, Shikanian, A, Shmeleva, A, Snesarev, A, Speransky, M, Sulin, V, Tikhomirov, V, Vasileva, L, Yakimenko, M, Bondarenko, V, Dolgoshein, B, Konstantinov, A, Nevsky, P, Romanyuk, A, Semenov, S, Smirnov, S, Sosnovtsev, V, Bashindzhagian, GL, Basiladze, SG, Chudakov, EA, Erasov, AB, Grishkevich, Ya, Karmanov, DE, Kramarenko, VA, Larichev, AN, Melikhov, DI, Merkin, MM, Nikitin, NV, Rizatdinova, FK, Selikov, AV, Sivoklokov, SYu, Smirnova, LN, Zhukov, VYu, Zverev, EG, Batrakov, A, Chilingarov, A, Fedotov, M, Gaponenko, I, Klimenko, S, Kollegov, M, Kozlov, V, Kuper, E, Merzlyakov, Yu, Panin, V, Shamov, A, Telnov, V, Tikhonov, Yu, Velikzhanin, Yu, Amelin, DV, Ammosov, VV, Antipov, YuM, Batarin, V, Bogolyubsky, MYu, Borisov, AA, Borisov, E, Bozhko, NI, Bryzgalov, VV, Chekulaev, SV, Denisov, SP, Dushkin, AYu, Fakhrutdinov, R, Fenyuk, AB, Gapienko, VA, Gilitsky, YuV, Goryachev, V, Gouz, YuP, Karyukhin, A N, Khokhlov, YuA, Kirsanov, MM, Klyukhin, V, Kozhin, AS, Kononov, AI, Konstantinov, V, Kopikov, SV, Korotkov, VA, Kostrikov, ME, Kostyukhin, VV, Kravtsov, V I, Kulemzin, A, Kurchaninov, LL, Lapin, VV, Levitsky, ML, Los, S, Maksimov, V, Myagkov, AG, Mikhailin, VN, Minaenko, AA, Moiseev, AM, Onuchin, VA, Pleskach, AV, Salomatin, YuI, Senko, VA, Shein, I, Soldatov, AP, Solodkov, AA, Solovianov, OV, Starchenko, EA, Sviridov, Yu, Sytnik, VV, Chmil, V, Chuntonov, A, Tikhonov, VV, Tsyupa, Yu, Usenko, E, Vorobev, AP, Vovenko, AS, Zaets, VG, Zaitsev, AM, Zimin, S, Zmushko, V, Fedin, O, Filimonov, V, Gavrilov, G, Ivochkin, V, Khomutnikov, V, Kolos, S, Krivshich, A, Lochak, I, Maleev, V, Nadtochy, A, Patrichev, S, Prokofev, D, Ryabov, Yu, Shchegelsky, V, Solovev, I, Spiridenkov, E, Zalite, A, Aleksandrov, I, Alekseev, G, Alikov, B, Anosov, V, Astvatsaturov, A, Azhgirei, L, Bannikov, A, Baranov, SA, Boyko, I, Budagov, Yu, Chelkov, G, Cheplakov, A, Chirikov-Zorin, I, Chlachidze, G, Dodonov, V, Feshchenko, A, Flyagin, V, Glagolev, V, Golikov, V, Golubykh, S, Gornushkin, Yu, Ignatenko, M, Zhuravlev, N, Kakurin, S, Kalinichenko, V, Kazarinov, M, Kazymov, A, Kekelidze, V, Khasanov, A, Khomenko, B, Khovansky, N, Kotov, V, Kovtun, V, Krumshtein, Z, Kukhtin, V, Kulchitsky, Yu, Kuznetsov, O, Ladygin, E, Lazarev, A, Lebedev, A, Lyablin, M, Lomakin, Yu, Malyshev, VL, Malyukov, S, Merekov, Yu, Merzlyakov, S, Minashvili, I, Nikolenko, M, Nozdrin, A, Obudovsky, V, Olshevsky, A, Peshekhonov, V, Pisarev, I, Podkladkin, S, Pose, R, Pukhov, O, Romanov, V, Rumyantsev, V, Rusakovich, N, Ryabchenko, K, Salihagic, D, Samoilov, V, Savin, I, Shchelchkov, A, Sedykh, Yu, Semenov, A, Senchishin, V, Shabalin, D, Shalyugin, A, Shigaev, V, Shilov, Y, Sisakian, A, Snyatkov, V, Sorokina, Yu, Tkachev, L, Tokmenin, V, Topilin, N, Tskhadadze, E, Usov, Yu, Vertogradov, L, Vinogradov, V, Vorozhtsov, S, Yamburenko, V, Yarygin, G, Yatsunenko, Yu, Zhuravlev, V, Ban, J, Bruncko, D, Chochula, P, Dubnickova, AZ, Ferencei, J, Jusko, A, Kladiva, E, Kubinec, P, Kurca, T, Masarik, J, Povinec, P, Rosinsky, P, Stanicek, J, Stavina, P, Strizenec, P, Sykora, I, Tokar, S, Vanko, J, Cindro, V, Filipcic, A, Kramberger, G, Mikuz, M, Tadel, M, Zontar, D, Blanchot, G, Bosman, M, Casado, P, Cavalli-Sforza, M, Chmeissani, M, Crespo, JM, Delfino, M, Fernandez, E, Grauges, E, Juste, A, Martinez, M, Miralles, L, Pacheco, A, Park, IC, Perlas, JA, Riu, I, Vichou, I, Barreiro, F, del Peso, J, Hervas, L, Labarga, L, Albiol, F, Ballester, F, Benlloch, J M, Bernabeu, J, Cases, R, Castillo, MV, Ferrer, A, Fuster, J, Garcia, C, Gonzalez, V, Gil, I, Lopez, JM, Romance, JB, Salt, J, Sanchez, J, Sanchis, E, Sanchis, MA, Sebastia, A, Zuniga, J, Almehed, S, Carling, H, Danielsson, H, Egede, U, Hedberg, V, Jarlskog, G, Lorstad, B, Lundberg, B, Mjornmark, U, Soderberg, M, Carlson, P, Clement, C, Lund-Jensen, B, Pearce, M, Soderqvist, J, Vanyashin, A, Agnvall, S, Berglund, S, Bohm, C, Engstrom, M, Fristedt, A, Hellman, S, Holmgren, S O, Johansson, E, Jon-And, KB, Sellden, B, Silverstein, S, Tardell, S, Yamdagni, N, Zhao, X, Bingefors, N, Botner, O, Brenner, R, Bystrom, O, Ekelof, T, Gustafsson, L, Hallgren, A, Kullander, S, Staaf, P, Beringer, J, Borer, K, Hess, M, Lehmann, G, Mommsen, R, Pretzl, K, Bonino, R, Clark, AG, Couyoumtzelis, C, Demierre, P, Kambara, H, Kowalewski, R, La Marra, D, Leger, A, Perrin, E, Vuaridel, B, Wu, X, Arik, E, Birol, I, Cicek, Z, Cuhadar, T, Gun, S, Hacinliyan, A, Mailov, A, Nurdan, K, Perdahci, Z, Turk, I, Unel, G, Charlton, DG, Dowell, JD, Garvey, J, Hillier, S J, Homer, R J, Jovanovic, P, Kenyon, IR, McMahon, TJ, O'Neale, SW, Rees, DL, Staley, RJ, Watkins, PM, Watson, AT, Watson, N K, Wilson, JA, Batley, JR, Carter, JR, Drage, L, Goodrick, MJ, Hill, JC, Munday, DJ, Parker, MA, Robinson, D, Wyllie, KH, Boyle, O, Candlin, DJ, Candlin, ERS, Knowles, IG, Playfer, SM, Doyle, AT, Flavell, AJ, Lynch, JG, Martin, DJ, O'Shea, V, Raine, C, Saxon, DH, Skillicorn, IO, Smith, KM, Brodbeck, TJ, Henderson, RCW, Hughes, GH, Komorowski, T, Ratoff, PN, Sloan, T, Allport, PP, Booth, PSL, Carroll, LJ, Cooke, PA, Greenall, A, Houlden, MA, Jackson, JN, Jones, TJ, King, BT, Moreton, A, Richardson, JD, Smith, NA, Sutcliffe, P, Turner, PR, Beck, GA, Carter, AA, Eisenhandler, E F, Kyberd, P, Landon, M, Lloyd, SL, Martin, AJ, Pentney, JM, Pritchard, T W, Thompson, G, Blair, GA, George, S, Green, BJ, Medcalf, T, Strong, JA, Bignall, P, Clarke, P, Cranfield, R, Crone, G, Esten, M, Jones, T, Lane, J, Sherwood, P, Duerdoth, IP, Dunne, PW, Finnegan, PF, Foster, JM, Freestone, J, Gilbert, SD, Hughes-Jones, R E, Ibbotson, M, Kolya, SD, Loebinger, FK, Marshall, R, Mercer, D, Snow, S, Thompson, RJ, Bibby, JH, Buira-Clark, D, Fox-Murphy, A, Grewal, A, Harris, FJ, Hawes, BM, Hill, J, Holmes, A, Howell, D, Hunt, SJ, Kundu, N, Lloyd, J, Loken, JG, Nickerson, RB, Reichold, A, Renton, PB, Segar, M, Wastie, R L, Weidberg, AR, Apsimon, R J, Baines, J T, Baynham, D E, Botterill, D R, Campbell, DA, Clifft, RW, Edwards, J P, Edwards, M, English, RL, Fisher, S M, Gee, C N P, Gibson, M D, Gillman, A R, Hart, J C, Hatley, RW, Haywood, S J, Hill, DL, Madani, S, McCubbin, N A, McPhail, DJ, Middleton, R P, Morrissey, MC, Murray, W J, Nichols, A, Norton, P R, Payne, B T, Perera, VJO, Phillips, P W, Pilling, A, Quinton, S P H, Saunders, B J, Seller, P, Shah, T P, Tappern, GJ, Tyndel, M, White, DJ, Wickens, FJ, Booth, CN, Buttar, CM, Cartwright, SL, Combley, FH, Lehto, MH, Sellin, PJ, Spooner, NJC, Thompson, LF, Alam, MS, Athar, SB, Mahmood, A, Ovunc, S, Severini, H, Timm, S, Wappler, F, Zhichao, L, Berger, EL, Blair, R, Dawson, J, Guarino, V, Hill, N, May, EN, Nodulman, LJ, Price, LE, Proudfoot, J, Schlereth, JL, Stanek, R, Wagner, RG, Wicklund, A B, Cheu, E, Johns, K, Loch, P, Rutherfoord, J, Savin, A, Shaver, L, Shupe, M, Steinberg, J, Tompkins, D, De, K, Gallas, E, Li, J, Sawyer, L, Stephens, R, White, A, Barnett, M, Bintinger, D, Ciocio, A, Dahl, O, Einsweiler, K, Ely, R, Gilchriese, M, Haber, C, Hinchliffe, I, Holland, S, Joshi, A, Kipnis, I, Kleinfelder, S, Milgrome, O, Nygren, D, Palaio, N, Pengg, F, Shapiro, M, Siegrist, J, Spieler, H, Trilling, G, Hazen, E, Shank, J, Simmons, E, Whitaker, JS, Zhou, B, Behrends, S, Bensinger, JR, Blocker, C, Cunningham, J, Kirsch, LE, Lamoureux, J, Wellenstein, H, Citterio, M, Cullen, J, Gibbard, B, Gordeev, A, Gordon, H, Graf, N, Grachev, V, Kandasamy, A, Kotcher, J, Lissauer, D, Ma, H, Makowiecki, D, Murtagh, MJ, O'Connor, P, Paige, F, Polychronakos, V, Protopopescu, S, Radeka, V, Rahm, DC, Rajagopalan, S, Rescia, S, Smith, G, Sondericker, J, Stephani, D, Stumer, I, Takai, H, Chernyatin, V, Yu, B, Anderson, K, Blucher, E, Evans, H, Glenzinski, D, Merritt, F, Oreglia, M, Pilcher, J, Pod, E, Sanders, H, Shochet, M, Turcot, A, Cartiglia, N, Cunitz, H, Dodd, J, Gara, A, Leltchouk, M, Parsons, J, Seman, M, Shaevitz, M, Sippach, W, Willis, W, Fortney, LR, Goshaw, AT, Lee, AM, Oh, SH, Robertson, RJ, Wang, CH, Wesson, D, Baker, OK, Feldman, GJ, Franklin, MEB, Huth, J, Oliver, J, Hanson, G, Li, Z, Luehring, F, Ogren, H, Rust, DR, Lankford, AJ, Hackett, C, Pier, S, Schernau, M, Stoker, D, Haridas, P, Osborne, LS, Paradiso, JA, Pless, IA, Taylor, FE, Wadsworth, BF, Abolins, M, Brock, R, Bromberg, C, Edmunds, D, Ermolin, Yu, Gross, S, Huston, J, Laurens, P, Linnemann, J, Miller, R, Owen, D, Pope, BG, Richards, R, Weerts, H, Gold, M, Gorfine, G, Matthews, J, Seidel, S, Khandaker, M, McFarlane, K, Punjabi, V, Salgado, CW, Fortner, M, Sirotenko, V I, Willis, SE, Gutierrez, P, McMahon, T, Nemati, B, Skubic, P, Snow, J, Strauss, M, Dressnandt, N, Keener, P, Newcomer, FM, Van Berg, R, Williams, HH, Cleland, WE, Clemen, M, Bazizi, K, England, D, Ferbel, T, Ginther, G, Glebov, V, Haelen, T, Lobkowicz, F, Slattery, P, Zielinski, M, Dorfan, D, Dubbs, T, Grillo, A, Heusch, C, Kashigin, S, Litke, A, Popelvine, P, Sadrozinski, HFW, Seiden, A, Spencer, E, Coan, TE, Olness, FI, Skwarnicki, T, Stroynowski, R, Teplitz, V, Mann, A, Milburn, R, Napier, A, Sliwa, K, Downing, RW, Errede, D, Errede, S, Haney, MJ, Simaitis, VJ, Thaler, J, Burnett, TH, Chaloupka, V, Cook, V, Daly, C, Davisson, R, Forbush, D, Guldenmann, H, Lubatti, HJ, Mockett, PM, Reinhall, P, Rothberg, J, Wasserbaech, S, Zhao, T, Fasching, D, Gonzalez, S, Jared, RC, Pan, YB, Scott, IJ, Walsh, J, Wu, SL, Yamartino, JM, and Zobernig, G
5. ATLAS calorimeter performance
- Author
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ATLAS Collaboration, Airapetian, A, Grabsky, V, Hakopian, H, Vartapetian, A, Fares, F, Moorhead, GF, Sevior, ME, Taylor, GN, Tovey, SN, Alexiev, D, Donnelly, IJ, Varvell, KE, Williams, ML, Hashemi-Nezhad, R, Peak, L, Saavedra, A, Ulrichs, J, Girtler, P, Kiener, C, Kneringer, E, Kuhn, D, Rudolph, G, Abdinov, OB, Aliev, FM, Khalilzade, FT, Mehdiyev, RR, Rzaev, HJ, Usubov, ZU, Baturitsky, MA, Bogush, AA, Demchenko, AI, Gazizov, AZ, Gilevsky, VV, Golubev, VS, Levchuk, MI, Satsunkevich, IS, Shevtsov, VV, Caloba, LP, Galvez-Durand, F, Maidantchik, CL, Marroquin, F, Seixas, JM, Thome, ZD, da Silva, NC, Dietzsch, O, Leite, MAL, Sakanoue, MH, Takagui, EM, Zandona, F, Armstrong, WW, Burris, W, Gingrich, DM, Hewlett, JC, Holm, L, Mullin, S, Pinfold, JL, Schaapman, J, Soukup, J, Wampler, L, Axen, D, Mayer, JK, Orr, RS, Armitage, J, Dixit, M, Dubeau, J, Estabrooks, P, Losty, M, Neuheimer, E, O'Neill, M, Oakham, G, Azuelos, G, Ben El Fassi, A, Depommier, P, Leon-Florian, E, Leroy, C, Lorazo, B, Martin, JP, Marullo, F, Roy, P, Savard, P, Bailey, DC, Bhadra, S, Martin, JF, Sinervo, PK, Stairs, GG, Trischuk, W, Astbury, A, Birney, P, Hodges, T, Langstaff, R, Oram, C, Roberts, B, Rosvick, M, Wellisch, HP, Bishop, S, Fincke-Keeler, M, Honma, A, Keeler, R, Lefebvre, M, O'Neil, D, Poffenberger, P, Robertson, L, Roney, M, Sobie, R, Akesson, T, Anghinolfi, F, Bachy, G, Barberio, E, Benincasa, G, Bergsma, F, Bjorset, L, Blocki, J, Bloess, D, Bock, R, Bogaerts, J, Brawn, I, Burckhart, HJ, Butin, F, Campbell, M, Chesi, E, Chevalley, JL, Christiansen, J, Cobal, M, Dabrowski, W, Dauvergne, JP, Dell'Acqua, A, Denes, E, Dittus, F, Dobinson, R, Drakoulakos, D, Dufey, JP, Eerola, P, Efthymiopoulos, I, Ellis, N, Fabjan, CW, Farthouat, P, Flegel, W, Francis, D, Froidevaux, D, Gebart, R, Gianotti, F, Gildemeister, O, Hatch, M, Haug, F, Hauviller, C, Heeley, R, Heijne, E, Henriques, A, Hoffmann, HF, Hortnagl, C, Jarp, S, Jarron, P, Jenni, P, Jones, R, Kantardjian, G, Kaplon, J, Klempt, W, 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I, Spiridenkov, E, Zalite, A, Aleksandrov, I, Alekseev, G, Alikov, B, Anosov, V, Astvatsaturov, A, Azhgirei, L, Bannikov, A, Baranov, SA, Boyko, I, Budagov, Yu, Chelkov, G, Cheplakov, A, Chirikov-Zorin, I, Chlachidze, G, Dodonov, V, Feshchenko, A, Flyagin, V, Glagolev, V, Golikov, V, Golubykh, S, Gornushkin, Yu, Ignatenko, M, Zhuravlev, N, Kakurin, S, Kalinichenko, V, Kazarinov, M, Kazymov, A, Kekelidze, V, Khasanov, A, Khomenko, B, Khovansky, N, Kotov, V, Kovtun, V, Krumshtein, Z, Kukhtin, V, Kulchitsky, Yu, Kuznetsov, O, Ladygin, E, Lazarev, A, Lebedev, A, Lyablin, M, Lomakin, Yu, Malyshev, VL, Malyukov, S, Merekov, Yu, Merzlyakov, S, Minashvili, I, Nikolenko, M, Nozdrin, A, Obudovsky, V, Olshevsky, A, Peshekhonov, V, Pisarev, I, Podkladkin, S, Pose, R, Pukhov, O, Romanov, V, Rumyantsev, V, Rusakovich, N, Ryabchenko, K, Salihagic, D, Samoilov, V, Savin, I, Shchelchkov, A, Sedykh, Yu, Semenov, A, Senchishin, V, Shabalin, D, Shalyugin, A, Shigaev, V, Shilov, Y, Sisakian, A, Snyatkov, V, Sorokina, Yu, Tkachev, L, Tokmenin, V, Topilin, N, Tskhadadze, E, Usov, Yu, Vertogradov, L, Vinogradov, V, Vorozhtsov, S, Yamburenko, V, Yarygin, G, Yatsunenko, Yu, Zhuravlev, V, Ban, J, Bruncko, D, Chochula, P, Dubnickova, AZ, Ferencei, J, Jusko, A, Kladiva, E, Kubinec, P, Kurca, T, Masarik, J, Povinec, P, Rosinsky, P, Stanicek, J, Stavina, P, Strizenec, P, Sykora, I, Tokar, S, Vanko, J, Cindro, V, Filipcic, A, Kramberger, G, Mikuz, M, Tadel, M, Zontar, D, Blanchot, G, Bosman, M, Bravo, S, Cavalli-Sforza, M, Chmeissani, M, Crespo, JM, Delfino, M, Fernandez, E, Grauges, E, Juste, A, Martinez, M, Miralles, L, Pacheco, A, Park, IC, Perlas, JA, Ruiz, H, Vichou, I, Barreiro, F, del Peso, J, Hervas, L, Labarga, L, Albiol, F, Ballester, F, Benlloch, JM, Bernabeu, J, Cases, R, Castillo, MV, Ferrer, A, Fuster, J, Garcia, C, Gonzalez, V, Gil, I, Lopez, JM, Romance, JB, Salt, J, Sanchez, J, Sanchis, E, Sanchis, MA, Sebastia, A, Zuniga, J, Almehed, S, Carling, H, Danielsson, H, Egede, U, Hedberg, V, Jarlskog, G, Lorstad, B, Lundberg, B, Mjornmark, U, Soderberg, M, Carlson, P, Clement, C, Lund-Jensen, B, Pearce, M, Soderqvist, J, Vanyashin, A, Agnvall, S, Berglund, S, Bohm, C, Engstrom, M, Fristedt, A, Hellman, S, Holmgren, S O, Johansson, E, Jon-And, KB, Sellden, B, Silverstein, S, Tardell, S, Yamdagni, N, Zhao, X, Bingefors, N, Botner, O, Brenner, R, Bystrom, O, Ekelof, T, Gustafsson, L, Hallgren, A, Kullander, S, Staaf, P, Beringer, J, Borer, K, Hess, M, Lehmann, G, Mommsen, R, Pal, T, Pretzl, K, Bonino, R, Clark, AG, Couyoumtzelis, C, Demierre, P, Kambara, H, Kowalewski, R, La Marra, D, Leger, A, Perrin, E, Vuaridel, B, Wu, X, Arik, E, Birol, I, Cicek, Z, Cuhadar, T, Gun, S, Hacinliyan, A, Mailov, A, Nurdan, K, Perdahci, Z, Turk, I, Unel, G, Charlton, DG, Dowell, JD, Garvey, J, Hillier, S J, Homer, R J, Jovanovic, P, Kenyon, IR, McMahon, TJ, O'Neale, SW, Rees, DL, Staley, RJ, Watkins, PM, Watson, AT, Watson, N K, Wilson, JA, Batley, JR, Carter, JR, Drage, L, Goodrick, MJ, Hill, JC, Munday, DJ, Parker, MA, Robinson, D, Wyllie, KH, Boyle, O, Candlin, DJ, Candlin, ERS, Knowles, IG, Playfer, SM, Doyle, AT, Flavell, AJ, Lynch, JG, Martin, DJ, O'Shea, V, Raine, C, Saxon, DH, Skillicorn, IO, Smith, KM, Brodbeck, TJ, Henderson, RCW, Hughes, GH, Komorowski, T, Ratoff, PN, Sloan, T, Allport, PP, Booth, PSL, Carroll, LJ, Cooke, P A, Greenall, A, Houlden, MA, Jackson, JN, Jones, TJ, King, BT, Moreton, A, Richardson, JD, Smith, NA, Sutcliffe, P, Turner, PR, Beck, GA, Carter, AA, Eisenhandler, E F, Kyberd, P, Landon, M, Lloyd, SL, Martin, AJ, Pentney, JM, Pritchard, T W, Thompson, Blair, GA, George, S, Green, BJ, Medcalf, T, Strong, JA, Bignall, P, Clarke, P, Cranfield, R, Crone, G, Esten, M, Jones, T, Lane, J, Sherwood, P, Duerdoth, IP, Dunne, PW, Finnegan, PF, Foster, JM, Freestone, J, Gilbert, SD, Hughes-Jones, R E, Ibbotson, M, Kolya, SD, Loebinger, FK, Marshall, R, Mercer, D, Snow, S, Thompson, RJ, Bibby, JH, Buira-Clark, D, Fox-Murphy, A, Grewal, A, Harris, FJ, Hawes, BM, Hill, J, Holmes, A, Howell, D, Hunt, SJ, Kundu, N, Lloyd, J, Loken, JG, Nickerson, RB, Reichold, A, Renton, PB, Segar, AM, Wastie, R L, Weidberg, AR, Apsimon, R J, Baines, J T, Baynham, D E, Botterill, D R, Campbell, DA, Clifft, RW, Edwards, JP, Edwards, M, English, RL, Fisher, S M, Gee, C N P, Gibson, M D, Gillman, A R, Hart, J C, Hatley, RW, Haywood, S J, Hill, DL, Madani, S, McCubbin, N A, McPhail, DJ, Middleton, R P, Morrissey, MC, Murray, W J, Nichols, A, Norton, P R, Payne, B T, Perera, VJO, Phillips, P W, Pilling, A, Quinton, S P H, Saunders, B J, Seller, P, Shah, T P, Tappern, GJ, Tyndel, M, White, DJ, Wickens, FJ, Booth, CN, Buttar, CM, Cartwright, SL, Combley, FH, Lehto, MH, Sellin, PJ, Spooner, NJC, Thompson, LF, Alam, MS, Athar, SB, Mahmood, A, Ovunc, S, Severini, H, Timm, S, Wappler, F, Zhichao, L, Berger, EL, Blair, R, Dawson, J, Guarino, V, Hill, N, May, EN, Nodulman, LJ, Price, LE, Proudfoot, J, Schlereth, JL, Stanek, R, Wagner, RG, Wicklund, A B, Cheu, E, Johns, K, Loch, P, Rutherfoord, J, Savin, A, Shaver, L, Shupe, M, Steinberg, J, Tompkins, D, De, K, Gallas, E, Li, J, Sawyer, L, Stephens, R, White, A, Barnett, M, Bintinger, D, Ciocio, A, Dahl, O, Einsweiler, K, Ely, R, Gilchriese, M, Haber, C, Hinchliffe, I, Holland, S, Joshi, A, Kipnis, I, Kleinfelder, S, Milgrome, O, Nygren, D, Palaio, N, Pengg, F, Shapiro, M, Siegrist, J, Spieler, H, Trilling, G, Hazen, E, Shank, J, Simmons, E, Whitaker, JS, Zhou, B, Behrends, S, Bensinger, JR, Blocker, C, Cunningham, J, Kirsch, LE, Lamoureux, J, Wellenstein, H, Citterio, M, Cullen, J, Gibbard, B, Gordeev, A, Gordon, H, Graf, N, Grachev, V, Kandasamy, A, Kotcher, J, Lissauer, D, Ma, H, Makowiecki, D, Murtagh, MJ, O'Connor, P, Paige, F, Polychronakos, V, Protopopescu, S, Radeka, V, Rahm, DC, Rajagopalan, S, Rescia, S, Smith, G, Sondericker, J, Stephani, D, Stumer, I, Takai, H, Chernyatin, V, Yu, B, Anderson, K, Blucher, E, Evans, H, Glenzinski, D, Merritt, F, Oreglia, M, Pilcher, J, Pod, E, Sanders, H, Shochet, M, Turcot, A, Cartiglia, N, Cunitz, H, Dodd, J, Gara, A, Leltchouk, M, Parsons, J, Seman, M, Shaevitz, M, Sippach, W, Willis, W, Fortney, LR, Goshaw, AT, Lee, AM, Oh, SH, Robertson, RJ, Wang, CH, Wesson, D, Baker, OK, Feldman, GJ, Franklin, MEB, Huth, J, Oliver, J, Hanson, G, Li, Z, Luehring, F, Ogren, H, Rust, DR, Lankford, AJ, Hackett, C, Pier, S, Schernau, M, Stoker, D, Haridas, P, Osborne, LS, Paradiso, JA, Pless, IA, Taylor, FE, Wadsworth, BF, Abolins, M, Brock, R, Bromberg, C, Edmunds, D, Ermolin, Yu, Gross, S, Huston, J, Laurens, P, Linnemann, J, Miller, R, Owen, D, Pope, BG, Richards, R, Weerts, H, Gold, M, Gorfine, G, Matthews, J, Seidel, S, Khandaker, M, McFarlane, K, Punjabi, V, Salgado, CW, Fortner, M, Sirotenko, V I, Willis, SE, Gutierrez, P, McMahon, T, Nemati, B, Skubic, P, Snow, J, Strauss, M, Dressnandt, N, Keener, P, Newcomer, FM, Van Berg, R, Williams, HH, Cleland, WE, Clemen, M, Bazizi, K, England, D, Ferbel, T, Ginther, G, Glebov, V, Haelen, T, Lobkowicz, F, Slattery, P, Zielinski, M, Dorfan, D, Dubbs, T, Grillo, A, Heusch, C, Kashigin, S, Litke, A, Popelvine, P, Sadrozinski, HFW, Seiden, A, Spencer, E, Coan, TE, Olness, FI, Skwarnicki, T, Stroynowski, R, Teplitz, V, Mann, A, Milburn, R, Napier, A, Sliwa, K, Downing, RW, Errede, D, Errede, S, Haney, MJ, Simaitis, VJ, Thaler, J, Burnett, TH, Chaloupka, V, Cook, V, Daly, C, Davisson, R, Forbush, D, Guldenmann, H, Lubatti, H J, Mockett, PM, Reinhall, P, Rothberg, J, Wasserbaech, S, Zhao, T, Fasching, D, Gonzalez, S, Jared, RC, Pan, YB, Scott, IJ, Walsh, J, Wu, SL, Yamartino, JM, and Zobernig, G
6. Diabetic rats skin wounds treated with heterologous fibrin sealant followed by photobiomodulation therapy.
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de Alexandria FED, Silva NC, Assis L, Filho ALMM, Kido HW, Tarocco JC, Ferreira RS Jr, Barraviera B, Parizotto NA, Silva JF, Neto MADN, and Tim CR
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- Animals, Rats, Male, Low-Level Light Therapy methods, Wound Healing radiation effects, Rats, Wistar, Diabetes Mellitus, Experimental, Skin radiation effects, Skin injuries, Fibrin Tissue Adhesive
- Abstract
Diabetes mellitus is characterized by elevated blood glucose levels causing sometimes impairment of the body's ability to repair itself. Promising treatments for tissue repair have included photobiomodulation therapy and heterologous fibrin biopolymer (HFB). This study aimed to evaluate the impact of photobiomodulation therapy by LED, both as a standalone treatment and in conjunction with heterologous fibrin biopolymer in treatment of skin lesions of diabetic rats. Diabetes was induced using alloxan. Full-thickness skin wounds were induced on the backs of 56 Wistar rats, which were randomly allocated into four groups: control group, heterologous fibrin biopolymer group, photobiomodulation therapy by LED group, and photobiomodulation therapy by LED combined with heterologous fibrin biopolymer group. The treatments spanned two experimental periods, lasting 7 and 14 days. Notably, the HFB group exhibited results similar to those of the LED group concerning wound regression, while demonstrating superior resistance to healing. Interestingly, the LED + HFB group showed greater skin damage at 7 days, but an improved repair process at 14 days compared to the control group. The findings indicate that combining photobiomodulation by LED with HFB did not enhance wound healing in diabetic rats beyond the effects of each treatment alone. Both treatments were effective individually, with HFB showing particular strength in promoting collagen maturation and improving tissue biomechanical properties. This study contributes to the ongoing body of research on skin repair with this innovative HFB. Future clinical trials will be essential to validate this proposition., Competing Interests: Declarations Ethics approval The present study was approved by the Ethics Committee on the Use of Animal under number 0298/2019 and conducted according to the international norms of ethics on animal experimentation (National Research Council, 1996). Competing Interests The authors declare no competing interests., (© 2024. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.)
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- 2024
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7. Nano-enhanced benzylpenicillin: Bridging antibacterial action with anti-inflammatory potential against antibiotic-resistant bacteria.
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Gomes-da-Silva NC, França ÁRS, Dos Santos CC, Alencar LMR, Rosas EC, Corrêa LB, Lorentino CMA, Santos ALS, Ricci-Junior E, and Santos-Oliveira R
- Abstract
This study investigates the enhancement of benzylpenicillin's antibacterial properties using nanomedicine, specifically by developing benzylpenicillin nanoemulsions. To address the escalating issue of bacterial resistance, we employed the advanced techniques Raman spectroscopy and atomic force microscopy to analyze the nanoemulsions' molecular structure and characteristics. We then evaluated the impact of these nanoemulsions on nitric oxide production by macrophages to deternine their potential to modulate inflammatory responses. We further assessed the antibacterial effectiveness of the nanoparticles against the pathogens Streptococcus pyogenes (Group A Streptococcus) and Streptococcus agalactiae (Group B Streptococcus). The results of antibiograms showed significant efficacy against Gram-positive bacteria, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values, confirming their bactericidal potential. The investigation into the mechanism of action suggested substantial disruption to bacterial membrane integrity, underscoring a possible mode of antibacterial activity. Overall, the study provides valuable insights into the synergistic relationship between antibiotics and nanoparticles. In particular, it demonstrates the potential of benzylpenicillin nanoparticles to enhance the antimicrobial efficacy and influence inflammatory responses obtained by evaluating nitrite, IL-6 and TNF-α, offering promising avenues for future clinical applications and strategies to combat bacterial resistance., Competing Interests: Declaration of Competing interest The authors state that they have no conflict of interest., (Copyright © 2024. Published by Elsevier Masson SAS.)
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- 2024
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8. The hockey fans in training intervention for men with overweight or obesity: a pragmatic cluster randomised trial.
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Petrella RJ, Gill DP, Boa Sorte Silva NC, Riggin B, Blunt WM, Kfrerer M, Majoni M, Marsh J, Irwin JD, Stranges S, Zwarenstein M, and Zou G
- Abstract
Background: Obesity disproportionately impacts men's health yet fewer men engage in preventive healthcare. We examined the effectiveness of Hockey Fans in Training (Hockey FIT), a gender-sensitised lifestyle intervention that engages men with overweight/obesity through their passion as fans of a local sports team, on weight change and other health indicators., Methods: Pragmatic, cluster randomised trial (aged 35-65 years, body mass index ≥ 27 kg/m
2 ) within 42 community-based sites in Canada and the United States, randomly assigned (1:1) to intervention (Hockey FIT) or control (wait-list) and stratified by region. Sites were selected based on partnerships with local major junior/professional hockey teams and community implementation partners. Intervention participants received exercise and education during a three-month active phase (once-weekly, 90-min sessions) followed by a nine-month minimally-supported phase; control participants continued with usual activities. Primary outcome was weight change at 12 months. Assessment teams were blinded to group assignment including photos of weight measurements on digital scales, to provide proof of values recorded (post COVID-19). Analyses followed intent-to-treat. Trial registration: ClinicalTrials.gov, NCT03636282., Findings: Between November 13, 2018-November 12, 2021, 20 sites (n = 497) were allocated to intervention and 22 sites (n = 500) to control. Participants with baseline weight and weight at 3 or 12 months, were included in the primary analysis (20 intervention sites [n = 354]; 22 control sites [n = 425]). At 12 months, mean weight change was -2.02 kg (95% confidence interval [CI], -2.78 to -1.26) with intervention and -0.92 kg (CI, -1.58 to -0.26) with control (difference, -1.10 kg [CI, -2.11 to -0.09], p = 0.03). There were 22 non-study related serious adverse events (45.5% in intervention; 54.5% in control)., Interpretation: Hockey FIT reduced weight in men with overweight or obesity. Hockey FIT is an innovative approach to engage men at increased risk of non-communicable disease in effective health behaviour change, through their passion as fans of their local hockey team., Funding: Public Health Agency of Canada; Canadian Institutes of Health Research., Competing Interests: We declare no competing interests., (© 2024 The Author(s).)- Published
- 2024
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9. Copper biomarkers and their relationship with dyslipidemia in women with obesity.
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da Silva LD, da Silva NC, Chaves BMS, Santos LR, de Sousa TGV, de Oliveira EHS, da Cunha Soares T, de Sousa Melo SR, Henriques GS, de Oliveira FE, Severo JS, Martins JA, Barros EML, de Moura MSB, and do Nascimento Marreiro D
- Abstract
Adipose tissue dysfunction influences the development of dyslipidemias associated with obesity, however, the mechanisms are still unclear. In this sense, the literature highlights the role of copper in cholesterol synthesis, contributing to the increase in concentrations of this lipid fraction and consequently to the manifestation of dyslipidemia. The objective of the study was to investigate the relationship between copper parameters and lipid profile markers in women with obesity. This is a cross-sectional study involving women aged 20 to 50 years divided into a case group (BMI ≥ 35 kg/m
2 ) and a control group (BMI between 18.5 and 24.9 kg/m2 ). Copper concentrations in plasma and erythrocytes were determined by inductively coupled plasma optical emission spectrophotometry and ceruloplasmin activity by spectrophotometry. The lipid fractions were analyzed according to the enzymatic colorimetric method, using an automatic biochemical analyzer. Participants with obesity had elevated concentrations of copper in plasma and reduced concentrations in erythrocytes compared to the control group, but there was no significant difference in ceruloplasmin activity between the groups. The research does not identify a correlation between copper parameters and serum concentrations of lipid fractions, which does not allow inferring the role of copper in the manifestation of dyslipidemia in obesity., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)- Published
- 2024
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10. Copper biomarkers and their relationship with parameters of insulin resistance in obese women.
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da Silva NC, da Silva LD, Chaves BMS, de Oliveira EHS, Barros EML, de Oliveira FE, Henriques GS, Pereira IC, Severo JS, Dos Santos LR, de Moura MSB, da Cunha Soares T, de Sousa TGV, de Sousa Melo SR, and do Nascimento Marreiro D
- Abstract
Some studies have demonstrated the involvement of high concentrations of copper in the manifestation of insulin resistance in individuals with obesity. The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case-control clinical study involving 203 women aged between 20 and 50 years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p < 0.05) between groups. The study identified a significant positive correlation between plasma copper and fasting insulin values and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (p < 0.05). The results of this study demonstrate that obese women have high copper concentrations in plasma and lower concentrations in erythrocytes. Furthermore, the significant positive correlation between plasma copper and fasting insulin and HOMA-IR index suggests the influence of this mineral on glycemic control parameters in obese women., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2024
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11. Association of uric acid with length of stay and mortality in pediatric hospitalized population.
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Siqueira AGS, da Silva NC, de Oliveira EP, and Pena GDG
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- Humans, Female, Male, Retrospective Studies, Child, Adolescent, Child, Preschool, Infant, Hospitalization, Risk Factors, Logistic Models, Uric Acid blood, Length of Stay, Hospital Mortality
- Abstract
Purpose: Elevated uric acid (UA) levels have been associated with acute and chronic diseases, which could affect the prognosis of pediatric hospitalized patients. However, the association of UA levels with length of hospital stay (LOS) and mortality in hospitalized children and adolescents remains unknown. Therefore, the aim of this study was to evaluate the association of serum UA levels with in-hospital mortality and prolonged LOS in hospitalized children and adolescents., Methods: A retrospective cohort study was conducted, involving 128 patients under 18 years of age, admitted to a tertiary-care hospital between January 2014 and December 2018. UA levels were assessed with an average of 3 days before the in-hospital outcome (discharge or death). Logistic regression was used to determine the association of UA with prolonged LOS (defined as over 30 days of hospitalization), while Cox regression multivariate analysis was employed to assess UA as a predictor of in-hospital mortality., Results: UA levels showed an inverse association with prolonged LOS. Specifically, for every 1 mg/dL increase in UA level, the odds of experiencing prolonged LOS decreased by 31% (OR = 0.69; 95% CI: 0.50-0.95). Additionally, individuals with elevated UA levels had lower odds of prolonged LOS (OR = 0.23; 95% CI: 0.08-0.66). However, UA levels were not associated with in-hospital mortality (HR = 1.63; 95% CI: 0.94-2.82)., Conclusion: Serum UA was inversely associated with LOS among children and adolescents, but no association was observed with in-hospital mortality., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
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- 2024
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12. Nanoencapsulation of active compounds in chitosan by ionic gelation: Physicochemical, active properties and application in packaging.
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Silva NC, Chevigny C, Domenek S, Almeida G, Assis OBG, and Martelli-Tosi M
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- Gels chemistry, Nanoparticles chemistry, Drug Compounding, Chitosan chemistry, Food Packaging instrumentation
- Abstract
The ionic gelation technique using chitosan to encapsulate active compounds has received lots of attention in the literature due to its ease-of-use and known biodegradability, biocompatibility and antimicrobial properties of the polymer. In this review, main studies from the last five years involving encapsulation of active compounds (natural and commercial/synthetic) are brought together in order to understand the encapsulation mechanisms of components with chitosan as well as the physical, chemical and morphological properties of the resulting particles. The application of these nanostructures in polymeric films was then investigated, since additives for packaging are an attractive premise and have only recently started being studied in the literature. Herein, comparisons are made between free and encapsulated bioactive compounds in different film matrices, as well as the effect of this activation on structure. Finally, this work details the mechanisms involved in the production of chitosan nanoparticles with active compounds and encourages new studies to focus on their application in packaging., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2025
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13. Decision tree model development and in silico validation for avoidable hospital readmissions at 30 days in a pediatric population.
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Silva NC, Amaral LRD, Gomes MS, Bertarini PLL, Albertini MK, Backes AR, and Pena GDG
- Abstract
Background and Objective: identifying patients at high risk of avoidable readmission remains a challenge for healthcare professionals. Despite the recent interest in Machine Learning in this topic, studies are scarce and commonly using only black box algorithms. The aim of our study was to develop and validate in silico an interpretable predictive model using a decision tree inference to identify pediatric patients at risk of 30-day potentially avoidable readmissions., Methods: a retrospective cohort study was conducted with all patients under 18 years admitted to a tertiary university hospital. Demographic, clinical and nutritional data were collected from electronic databases. The outcome was the potentially avoidable 30-day readmissions. The J48 algorithm was used to develop the best-fit trees capable of classifying the outcome efficiently. Leave-one-out cross-validation was applied and we computed the area under the receiver operating curve (AUC)., Results: the most important attributes of the model were C-reactive protein, hemoglobin and sodium levels, besides nutritional monitoring. We obtained an AUC of 0.65 and accuracy of 63.3 % for the full training and leave-one-out cross-validation., Conclusion: our model allows the identification of 30-day potentially avoidable readmissions through practical indicators facilitating timely interventions by the medical team, and might contribute to reduce this outcome.
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- 2024
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14. Archaeological findings show the extent of primitive characteristics of maize in South America.
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Costa FM, Vidal R, de Almeida Silva NC, Veasey EA, de Oliveira Freitas F, and Zucchi MI
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- South America, Mexico, Domestication, Zea mays, Archaeology
- Abstract
Scientific research has suggested that maize spread from Mexico and arrived in lowland South America in a state of partial domestication. However, archaeological samples with primitive morphological characteristics that corroborate this finding have not been recorded in the region thus far. Unexpectedly, many samples were identified in the Peruaçu Valley with characteristics never previously observed in South America. These archaeological samples with primitive characteristics, which are the focus of this work, represent the furthest records from the center of origin of the species and the longest duration of the maintenance of such characteristics (between 1010 and 570 years before present). The findings of this study, including archaeological samples, native races, and samples of teosinte, attest to a long history of maize diversification in lowland South America.
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- 2024
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15. Ultrasound-assisted extraction of bioactives as a strategic step for chemical pretreatments in nanocellulose production from acerola by-products.
- Author
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Silva NC, Silva MJ, Assis OBG, and Martelli-Tosi M
- Subjects
- Hydrolysis, Nanofibers chemistry, Ultrasonic Waves, Malpighiaceae chemistry, Cellulose chemistry
- Abstract
Acerola by-products (AB) have been used as raw material for extracting active compounds; however, there were no studies related to the use of the remaining acerola by-product (RAB) from this extraction. This portion still has fibers and can be used for the production of cellulose nanofibrils (CNFs); therefore, the main objective of this study was to evaluate the production of CNFs using AB and RAB and to investigate whether the extraction can be a treatment step before bleaching/acid hydrolysis. AB and RAB were characterized before and after being chemically treated (AB_CT and RAB_CT, respectively). The fibers extracted from the RAB showed the highest cellulose contents (RAB: 36.6 % and RAB_CT: 69.9 %), suggesting that the extraction process had an impact on by-product defibrillation. The same trends were observed for CNFs produced by acid hydrolysis. CNFs based on RAB showed higher yield (CNF_RAB: 25.2 % and CNF_RAB_CT: 24.2 %), higher crystallinity index (CNF_RAB: 68.3 % and CNF_RAB_CT: 71.7 %) and higher thermal stability compared to CNFs extracted from AB and AB_CT. This study proved that it is feasible to use by-products after removing the active compounds for CNF production without other pre-treatments or in association with chemical treatment to obtain more crystalline and thermally stable CNFs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)
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- 2024
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16. Sleep disturbance in children with attention-deficit hyperactivity disorder: relationship with melatonin and behavior.
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de Souza ALDM, Giacheti CM, Do Couto MCH, Galina Spilla CS, da Silva NC, Proença M, and Pinato L
- Subjects
- Humans, Child, Male, Female, Adolescent, Saliva metabolism, Saliva chemistry, Surveys and Questionnaires, Attention Deficit Disorder with Hyperactivity epidemiology, Melatonin metabolism, Sleep Wake Disorders epidemiology, Actigraphy
- Abstract
Aim: To evaluate the prevalence and types of sleep problems and their correlations with melatonin content and behavior in Attention-Deficit Hyperactivity Disorder (ADHD) children., Method: Sleep in ADHD children and typically developing children (TD) aged 6-14 was assessed by the Sleep Disorders Scale for Children (SDSC) and actigraphy, salivary melatonin quantified by ELISA, and behavior was analyzed using the Strengths and Difficulties Questionnaire., Results: ADHD children showed a higher frequency of sleep disturbances, higher sleep latency, and lower sleep efficiency than in the TD group. The ADHD group presented lower melatonin nocturnal content compared to the TD group. Disorders of Initiating and Maintaining Sleep (DIMS) was moderately associated with nocturnal melatonin. The total behavior difficulties were correlated with Disorders of Initiating and Maintaining Sleep (DIMS), Sleep/Wake Transition Disorders (SWTD), Disorders of Excessive Somnolence (DES), Sleep Hyperhidrosis (SHY) and Total SDSC Score. The behavior was the only determinant of the total SDSC score (R
2 = 0.499; p < 0.002)., Conclusion: This study provides, for the first time, evidence that among the frequent sleep disturbances in ADHD, the disorders in initiating and maintaining sleep are associated with the low levels of melatonin found in this population. Additionally, these, along with other sleep disturbances, are linked to behavioral problems in ADHD.- Published
- 2024
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17. Effect of nitrogen fertilization and shading on morphogenesis, structure and leaf anatomy of Megathyrsus maximus genotypes.
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Lopes ADR, Lage Filho NM, do Rêgo AC, Domingues FN, da Silva TC, Faturi C, da Silva NC, and da Silva WL
- Abstract
The use of exotic grasses of African origin for pastures in Brazil has been a major advancement in livestock production, but little is known about the responses of these grasses to nitrogen fertilizers associated with shading. In this study, the morphogenetic, structural, and leaf anatomical characteristics of Megathyrsus maximus cultivars' Tamani and Quênia were investigated as a function of N dose and shade. Morphogenetic and structural characteristics and leaf anatomy were studied under three shading levels (0, 30, and 50 %) and four N doses (0, 100, 200, and 300 kg N ha
-1 ) to simulate growth in a silvopastoral system. When comparing the cultivars, Quênia was more efficient in terms of phyllochron up to fertilization with 100 kg N ha-1 . The leaf senescence rate of Tamani was higher than that of Quênia at the 30 and 50 % shade levels. The total area (TA) occupied by leaf tissues decreased in Quênia as a function of the increase in N fertilization, whereas the TA of Tamani did not change. The thickness of the adaxial epidermis was greater in Quênia (0.68 µm) than in Tamani (0.50 µm) when not fertilized. The area occupied by the mesophyll was greater in both cultivars when they received fertilization equivalent to 300 kg N ha-1 . Quênia grass has a smaller phyllochron than Tamani grass, due to the rapid reconstruction of its photosynthetic apparatus, especially when it receives higher levels of nitrogen fertilization. However, Tamani grass has a greater distribution of plant tissues. The mesophyll area is larger in Tamani grass due to the greater presence of chloroplasts, which facilitates digestion by animals. The Tamani modified the leaf anatomical tissues more significantly in relation to shading, whereas the Quênia modified them in relation to N fertilization, which reinforces the suggestion of a more appropriate use of Tamani in silvopastoral systems., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Lopes, Lage Filho, do Rêgo, Domingues, Silva, Faturi, Silva and da Silva.)- Published
- 2024
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18. Effects of blood and root-dentin cleaning on the porosity and bond strength of a collagen bioceramic material.
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Saltareli FM, Castro-Raucci LMS, Miranda CES, Tavella-Silva NC, Oliveira IR, and Raucci-Neto W
- Subjects
- Porosity, Cattle, Animals, Tooth Root chemistry, Silicates chemistry, Calcium Compounds chemistry, Dental Bonding methods, Aluminum Compounds chemistry, Ceramics chemistry, Materials Testing, Biocompatible Materials chemistry, Oxides chemistry, Root Canal Filling Materials chemistry, Drug Combinations, Sodium Hypochlorite chemistry, Dentin drug effects, Collagen chemistry, Blood
- Abstract
To assess the effect of cleaning protocols on dentin contaminated with blood in reparative endodontic materials, bovine root samples were divided: no contamination (N); contamination (P); contamination and cleaning with saline (S), 2.5% NaOCl+saline (Na) or 2.5% NaOCl+17% EDTA+saline (NaE) and filled with: mineral trioxide aggregate (MTA), calcium-aluminate-cement (C), or C+collagen (Ccol) (n=13). The samples were evaluated for porosity, chemical composition, and bond strength. MTA porosity was lower than C (p=0.02) and higher than Ccol (p<0.001). P and NaE were similar (p=1.00), but higher than the other groups (p<0.001). MTA bond strength was similar to Ccol (p=0.777) and lower than C (p=0.028). P presented lower bond strength than the N (p<0.001); S and Na were similar to each other (p=0.969), but higher than P and lower than N (p<0.001). It was observed a predominance of mixed and cohesive failures. None of the samples showed Ca/P ratio values similar to human hydroxyapatite. This study showed that contamination with blood increased the materials porosity, but dentin cleaning with 2.5% NaOCl reduced this effect, and the collagen additive reduced the material porosity. Furthermore, blood contamination reduced the materials bond strength, and cleaning with saline or 2.5% NaOCl diminished this effect.
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- 2024
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19. Magnesium whitlockite nanoparticles: Hydrothermal synthesis, anti-inflammatory and anti-cancer potential.
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Maximiano LV, Correa LB, Gomes-da-Silva NC, da Costa LS, Da Silva MGP, Chaves AV, Franco ML, Fechine PBA, de Menezes AS, Santos-Oliveira R, and Andrade Neto DM
- Subjects
- Humans, Cell Line, Tumor, Animals, Particle Size, Interleukin-6 metabolism, Mice, Drug Screening Assays, Antitumor, Tumor Necrosis Factor-alpha metabolism, Cell Survival drug effects, Surface Properties, Nitric Oxide metabolism, Nitric Oxide biosynthesis, Calcium Phosphates, Magnesium chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents chemical synthesis, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents chemistry, Anti-Inflammatory Agents chemical synthesis, Cell Proliferation drug effects, Nanoparticles chemistry
- Abstract
This study revealed the potential of magnesium whitlockite [WH: Ca
18 Mg2 (HPO4 )2 (PO4 )12 ] nanoparticles (WH NPs) for anti-inflammatory and anti-cancer therapies. Although magnesium whitlockite possesses promising biological properties, its effects on inflammation and cancer remain unexplored. In this study, we address this gap by synthesizing WH NPs and demonstrating their multifaceted functionalities. Through detailed characterization, we revealed the synthesis pathway involving brushite as a precursor, with magnesium ions incorporated during hydrothermal treatment. WH NPs exhibited anti-inflammatory properties by significantly reducing the production of key inflammatory markers (NO, TNF-α, and IL-6). Furthermore, they display promising anti-cancer activity by inhibiting the proliferation of MDA-MB-231 breast cancer cells. Our findings not only establish a deeper understanding of WH NP synthesis but also highlight their potential for the development of innovative cancer and inflammatory treatments., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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20. The Association of the 24-Hour Activity Cycle Profiles With Cognition in Older Adults With Mild Cognitive Impairment: A Cross-Sectional Study.
- Author
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Balbim GM, Falck RS, Boa Sorte Silva NC, Kramer AF, Voss M, and Liu-Ambrose T
- Subjects
- Humans, Male, Cross-Sectional Studies, Female, Aged, Activity Cycles, Exercise physiology, Middle Aged, Independent Living, Aged, 80 and over, Cognitive Dysfunction physiopathology, Cognition physiology, Actigraphy, Sedentary Behavior, Sleep physiology
- Abstract
Background: The relationship of cognition and the 24-h activity cycle (24-HAC), encompassing physical activity, sedentary behavior, and sleep, in older adults with mild cognitive impairment (MCI) remains uncertain. Distinct combinations of 24-HAC behaviors can characterize unique activity profiles and influence cognition. We aimed to characterize 24-HAC activity profiles in older adults with MCI and assess whether differences in cognition exist across profiles., Methods: We conducted a cross-sectional analysis utilizing baseline data from 3 randomized controlled trials involving 253 community-dwelling older adults (55 + years) with MCI (no functional impairment, dementia diagnosis, and Montreal Cognitive Assessment score <26/30). Using MotionWatch8© wrist-worn actigraphy (+5 days), we captured the 24-HAC. Cognition was indexed by the Alzheimer's Disease Assessment Scale Cognitive Plus (ADAS-Cog-Plus). Compositional data and latent profile analyses identified distinct 24-HAC activity profiles. Analysis of covariance examined whether 24-HAC activity profiles differed in cognition., Results: Four distinct activity profiles were identified. Profile 1 ("Average 24-HAC," n = 103) engaged in all 24-HAC behaviors around the sample average. Profile 2 ("Active Chillers," n = 70) depicted lower-than-average engagement in physical activity and higher-than-average sedentary behavior. Profile 3 ("Physical Activity Masters," n = 54) were the most active and the least sedentary. Profile 4 ("Sedentary Savants," n = 26) were the least active and the most sedentary. Sleep was similar across profiles. There were no significant differences in ADAS-Cog-Plus scores between 24-HAC activity profiles (p > .05)., Conclusions: Older adults with MCI exhibited four 24-HAC activity profiles conforming to recommended physical activity and sleep guidelines. Nonetheless, cognition was similar across these profiles., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.)
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- 2024
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21. Association between Sleep and Language Development in Children with Congenital Zika Syndrome.
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da Silva NC, Giacheti CM, Couto MCHD, de Jesus SS, Ribeiro EM, Verçosa IMC, and Pinato L
- Subjects
- Humans, Infant, Female, Male, Child, Preschool, Infant, Newborn, Cross-Sectional Studies, Sleep Wake Disorders physiopathology, Sleep Wake Disorders virology, Zika Virus physiology, Longitudinal Studies, Surveys and Questionnaires, Language Development Disorders physiopathology, Language Development Disorders virology, Zika Virus Infection complications, Zika Virus Infection physiopathology, Zika Virus Infection virology, Zika Virus Infection congenital, Language Development, Sleep physiology
- Abstract
Aim: Congenital Zika Virus Syndrome (CZS) presents notable hurdles to neurodevelopment, with language development emerging as a crucial aspect. This study investigates sleep patterns and language skills in children with CZS, aiming to explore the potential synchronization of sleep development with their neurodevelopment., Method: We studied cross-sectionally 135 children with CZS aged 0 to 48 months, investigating sleep using the BISQ Questionnaire. Language development was assessed using the Early Language Milestone Scale, while motor development and cognitive and social ability were assessed using the Bayley Scales of Infant and Young Child Development 3rd edition. We also studied longitudinally a cohort of 16 children (initially aged 0 to 12 months) whom we followed for four years, assessing at one-year intervals., Results: Sleep disturbances and language deficits were highly frequent in this population. In the 0-12 months group, a late bedtime and frequent nighttime awakenings were associated with poorer auditory expressive skills. At 13-24 months, nighttime awakenings were associated with poorer auditory expressive skills, while among 25-36-month-olds decreased auditory receptive skills were associated with longer sleep onset latency and reduced nighttime sleep duration., Conclusion: The brain alterations caused by Zika virus infection affect both sleep disturbances and delays in language development. It is possible that sleep disturbance may be a mediating factor in the pathway between CZS and delayed language development, as the three analyzed language skills showed a correlation with sleep parameters.
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- 2024
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22. Physical exercise, cognition, and brain health in aging.
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Boa Sorte Silva NC, Barha CK, Erickson KI, Kramer AF, and Liu-Ambrose T
- Subjects
- Humans, Neuronal Plasticity physiology, Cognitive Dysfunction physiopathology, Exercise physiology, Brain physiology, Aging physiology, Cognition physiology
- Abstract
Exercise training is an important strategy to counteract cognitive and brain health decline during aging. Evidence from systematic reviews and meta-analyses supports the notion of beneficial effects of exercise in cognitively unimpaired and impaired older individuals. However, the effects are often modest, and likely influenced by moderators such as exercise training parameters, sample characteristics, outcome assessments, and control conditions. Here, we discuss evidence on the impact of exercise on cognitive and brain health outcomes in healthy aging and in individuals with or at risk for cognitive impairment and neurodegeneration. We also review neuroplastic adaptations in response to exercise and their potential neurobiological mechanisms. We conclude by highlighting goals for future studies, including addressing unexplored neurobiological mechanisms and the inclusion of under-represented populations., Competing Interests: Declaration of interests The authors declare no competing interests in relation to this work., (Copyright © 2024. Published by Elsevier Ltd.)
- Published
- 2024
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23. The Effect of Computerized Cognitive Training, with and without Exercise, on Cortical Volume and Thickness and Its Association with Gait Speed in Older Adults: A Secondary Analysis of a Randomized Controlled Trial.
- Author
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Stein RG, Ten Brinke LF, Boa Sorte Silva NC, Hsu CL, Handy TC, Hsiung GR, and Liu-Ambrose T
- Abstract
Background: Slower walking is associated with changes in cortical volume and thickness. Computerized cognitive training (CCT) and exercise improve cortical volume and thickness and thus, may promote gait speed. Slowing of gait is predictive of Alzheimer's disease., Objective: To examine: 1) the effect of CCT, with or without physical exercise, on cortical volume and thickness and; 2) the association of changes in cortical volume and thickness with changes in gait speed., Methods: A subset of 124 adults ( n = 53), aged 65-85 years, enrolled in an 8-week randomized controlled trial and completed T1-weighted MRI and 4-meter walk at baseline and 8 weeks. Participants were randomized to: 1) active control (BAT; n = 19); 2) CCT ( n = 17); or 3) CCT preceded by exercise (Ex-CCT; n = 17). Change in cortical volume and thickness were assessed and compared across all groups using Freesurfer., Results: BAT versus CCT increased left rostral middle frontal gyrus volume ( p = 0.027) and superior temporal gyrus thickness ( p = 0.039). Ex-CCT versus CCT increased left cuneus thickness ( p < 0.001) and right post central gyrus thickness ( p = 0.005), and volume ( p < 0.001). Ex-CCT versus BAT increased left ( p = 0.001) and right ( p = 0.020) superior parietal gyri thickness. There were no significant between-group differences in gait speed ( p > 0.175). Increased left superior parietal volume ( p = 0.036, r = 0.340) and thickness ( p = 0.002, r = 0.348), right post central volume ( p = .017, r = 0.341) and thickness ( p = 0.001, r = 0.348), left banks of superior temporal sulcus thickness ( p = 0.002, r = 0.356), and left precuneus thickness ( p < 0.001, r = 0.346) were associated with increased gait speed., Conclusions: CCT with physical exercise, but not CCT alone, improves cortical volume and thickness in older adults. These changes may contribute to the maintenance of gait speed in aging., Competing Interests: The authors have no conflict of interest to report., (© 2024 – The authors. Published by IOS Press.)
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- 2024
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24. Improved intraindividual variability in cognitive performance following cognitive and exercise training in older adults.
- Author
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Boa Sorte Silva NC, Ten Brinke LF, Bielak AAM, Handy TC, and Liu-Ambrose T
- Subjects
- Aged, Humans, Exercise psychology, Exercise Therapy methods, Walking, Aged, 80 and over, Cognition, Cognitive Dysfunction
- Abstract
Objective: Increased intraindividual variability (IIV) of cognitive performance is a marker of cognitive decline in older adults. Whether computerized cognitive training (CCT) and aerobic exercise counteracts cognitive decline by reducing IIV is unknown. We investigated the effects of CCT with or without aerobic exercise on IIV in older adults., Methods: This was a secondary analysis of an 8-week randomized controlled trial. Older adults (aged 65-85 years) were randomized to CCT alone ( n = 41), CCT with aerobic exercise ( n = 41), or an active control group ( n = 42). The CCT group trained using the Fit Brains® platform 3×/week for 1 hr (plus 3×/week of home-based training). The CCT with aerobic exercise group received 15 min of walking plus 45 min of Fit Brains® 3×/week (plus 3×/week of home-based training). The control group received sham exercise and cognitive training (3×/week for 1 hr). We computed reaction time IIV from the Dimensional Change Card Sort Test, Flanker Inhibitory Control and Attention Test (Flanker), and Pattern Comparison Processing Speed Test (PACPS)., Results: Compared with the control group, IIV reduced in a processing speed task (PACPS) following CCT alone (mean difference [95% confidence interval]: -0.144 [-0.255 to -0.034], p < 0.01) and CCT with aerobic exercise (-0.113 [-0.225 to -0.001], p < 0.05). Attention (Flanker congruent) IIV was reduced only after CCT with aerobic exercise (-0.130 [-0.242 to -0.017], p < 0.05)., Conclusions: A CCT program promoted cognitive health via reductions in IIV of cognitive performance and combining it with aerobic exercise may result in broader benefits.
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- 2024
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25. Pathophysiology of non-cystic fibrosis bronchiectasis in children and adolescents with asthma: A protocol for systematic review and meta-analysis.
- Author
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da Silva NC, Malagutti BC, Ladeira JMCD, Grotta MB, and Toro AADC
- Abstract
Background: The pathophysiological mechanisms by which asthma and bronchiectasis are associated are still unclear. The association of these two diseases can result in more severe symptoms and a greater number of exacerbations., Objective: The aim of this systematic review is to collect evidence of the pathophysiology of non-cystic fibrosis bronchiectasis with associated asthma in children and adolescents, aged 6-18 years old., Methods: A systematic and comprehensive search will be performed using eight main databases, PubMed, PubMed PMC, BVS/BIREME, Scopus, EMBASE, Cochrane Library, Scielo and Web of Science. Articles will be searched from the earliest available time to July 2023. The studied population will be composed of children and adolescents with asthma and non-cystic fibrosis bronchiectasis. From the data obtained, all articles found will be transferred to the Rayyan platform. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols Checklist (PRISMA P-2015). In addition, if sufficient data are available, a meta-analysis will be conducted. Two independent reviewers will conduct the studies selection, data extraction, and risk of bias assessment. The outcome measures will be to analyze if non-cystic fibrosis bronchiectasis is related to a specific inflammatory profile., Discussion: A systematic review will provide better knowledge about the etiopathogenesis and causes of the association between asthma and bronchiectasis and its role in the severity and control of asthma. Identifying, selecting and critically evaluating studies on asthma and bronchiectasis, would be possible to illuminate the characteristics of children and adolescents with associated diagnoses and provide information to help individualized treatments in order to control and prevent complications. The findings of this study will be published in a peer-reviewed journal., Systematic Review Registration: The systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) in July 2023 (registration number CRD42023440355)., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 da Silva et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
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26. Disseminated tuberculosis in an immunocompetent 15-year-old adolescent.
- Author
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Martins EB, Duraes SM, Vilte RM, Carvalho FR, Dos Santos TB, Batzner CN, Da Silva NC, Ferreira LC, Ronchini KR, Vallim MT, McBenedict B, Malta LM, and Pinheiro PY
- Subjects
- Humans, Adolescent, Male, Tuberculosis, Cutaneous drug therapy, Tuberculosis, Cutaneous diagnosis, Tuberculosis, Cutaneous pathology, Tuberculosis, Pulmonary drug therapy, Tuberculosis, Osteoarticular drug therapy, Tuberculosis, Osteoarticular diagnosis, Immunocompetence, Antitubercular Agents therapeutic use
- Abstract
Tuberculosis is one of the oldest known diseases and it remains one of the main causes of morbidity and mortality, especially in developing countries. It is associated with social inequalities and affects different age groups. Tuberculosis in children and adolescents should be considered a sentinel event, since it is linked to a recent infection through contact with bacilliferous adults. We report an immunocompetent 15-year-old adolescent with tuberculosis, exhibiting pulmonary, osteoarticular, and cutaneous involvement. Conventional treatment with tuberculostatic drugs for a year had satisfactory results without sequelae.
- Published
- 2024
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27. IKZF1 plus is a frequent biomarker of adverse prognosis in Mexican pediatric patients with B-acute lymphoblastic leukemia.
- Author
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Garcia-Solorio J, Núñez-Enriquez JC, Jiménez-Olivares M, Flores-Lujano J, Flores-Espino F, Molina-Garay C, Cervera A, Casique-Aguirre D, Peñaloza-Gonzalez JG, Baños-Lara MDR, García-Soto Á, Galván-Díaz CA, Olaya-Vargas A, Aguilar HF, Mata-Rocha M, Garrido-Hernández MÁ, Solís-Poblano JC, Luna-Silva NC, Cano-Cuapio LS, Aristil-Chery PM, Herrera-Quezada F, Carrillo-Sanchez K, Muñoz-Rivas A, Flores-Lagunes LL, Mendoza-Caamal EC, Villegas-Torres BE, González-Osnaya V, Jiménez-Hernández E, Torres-Nava JR, Martín-Trejo JA, Gutiérrez-Rivera ML, Espinosa-Elizondo RM, Merino-Pasaye LE, Pérez-Saldívar ML, Jiménez-Morales S, Curiel-Quesada E, Rosas-Vargas H, Mejía-Arangure JM, and Alaez-Verson C
- Abstract
Background: Recurrent genetic alterations contributing to leukemogenesis have been identified in pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL), and some are useful for refining classification, prognosis, and treatment selection. IKZF1
plus is a complex biomarker associated with a poor prognosis. It is characterized by IKZF1 deletion coexisting with PAX5 , CDKN2A/2B , or PAR1 region deletions. The mutational spectrum and clinical impact of these alterations have scarcely been explored in Mexican pediatric patients with B-ALL. Here, we report the frequency of the IKZF1plus profile and the mutational spectrum of IKZF1, PAX5, CDKN2A/2B , and ERG genes and evaluate their impact on overall survival (OS) in a group of patients with B-ALL., Methods: A total of 206 pediatric patients with de novo B-ALL were included. DNA was obtained from bone marrow samples at diagnosis before treatment initiation. A custom-designed next-generation sequencing panel was used for mutational analysis. Kaplan-Meier analysis was used for OS estimation., Results: We identified the IKZF1plus profile in 21.8% of patients, which was higher than that previously reported in other studies. A significantly older age ( p=0.04 ), a trend toward high-risk stratification ( p=0.06 ), and a decrease in 5-year Overall Survival (OS) ( p=0.009 ) were observed, although heterogeneous treatment protocols in our cohort would have impacted OS. A mutation frequency higher than that reported was found for IKZF1 (35.9%) and CDKN2A/2B (35.9%) but lower for PAX5 (26.6%). IKZF1MUT group was older at diagnosis ( p=0.0002 ), and most of them were classified as high-risk (73.8%, p=0.02 ), while patients with CDKN2A/2BMUT had a higher leukocyte count ( p=0.01 ) and a tendency toward a higher percentage of blasts (98.6%, >50% blasts, p=0.05 ) than the non-mutated patients. A decrease in OS was found in IKZF1MUT and CDKN2A/2BMUT patients, but the significance was lost after IKZF1plus was removed., Discussion: Our findings demonstrated that Mexican patients with B-ALL have a higher prevalence of genetic markers associated with poor outcomes. Incorporating genomic methodologies into the diagnostic process, a significant unmet need in low- and mid-income countries, will allow a comprehensive identification of relevant alterations, improving disease classification, treatment selection, and the general outcome., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer, AM, declared a shared affiliation with the author RE-E to the handling editor at the time of review., (Copyright © 2024 Garcia-Solorio, Núñez-Enriquez, Jiménez-Olivares, Flores-Lujano, Flores-Espino, Molina-Garay, Cervera, Casique-Aguirre, Peñaloza-Gonzalez, Baños-Lara, García-Soto, Galván-Díaz, Olaya-Vargas, Aguilar, Mata-Rocha, Garrido-Hernández, Solís-Poblano, Luna-Silva, Cano-Cuapio, Aristil-Chery, Herrera-Quezada, Carrillo-Sanchez, Muñoz-Rivas, Flores-Lagunes, Mendoza-Caamal, Villegas-Torres, González-Osnaya, Jiménez-Hernández, Torres-Nava, Martín-Trejo, Gutiérrez-Rivera, Espinosa-Elizondo, Merino-Pasaye, Pérez-Saldívar, Jiménez-Morales, Curiel-Quesada, Rosas-Vargas, Mejía-Arangure and Alaez-Verson.)- Published
- 2024
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28. Aerobic exercise training effects on hippocampal volume in healthy older individuals: a meta-analysis of randomized controlled trials.
- Author
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Balbim GM, Boa Sorte Silva NC, Ten Brinke L, Falck RS, Hortobágyi T, Granacher U, Erickson KI, Hernández-Gamboa R, and Liu-Ambrose T
- Subjects
- Humans, Randomized Controlled Trials as Topic, Health Status, Hippocampus diagnostic imaging, Exercise, Cardiorespiratory Fitness
- Abstract
We conducted a meta-analysis of randomized controlled trials investigating the effects of aerobic exercise training (AET) lasting ≥ 4 weeks on hippocampal volume and cardiorespiratory fitness (CRF) in cognitively unimpaired, healthy older individuals. Random-effects robust variance estimation models were used to test differences between AET and controls, while meta-regressions tested associations between CRF and hippocampal volume changes. We included eight studies (N = 554) delivering fully supervised AET for 3 to 12 months (M = 7.8, SD = 4.5) with an average AET volume of 129.85 min/week (SD = 45.5) at moderate-to-vigorous intensity. There were no significant effects of AET on hippocampal volume (SMD = 0.10, 95% CI - 0.01 to 0.21, p = 0.073), but AET moderately improved CRF (SMD = 0.30, 95% CI 0.12 to 0.48, p = 0.005). Improvement in CRF was not associated with changes in hippocampal volume (b
SE = 0.05, SE = 0.51, p = 0.923). From the limited number of studies, AET does not seem to impact hippocampal volume in cognitively unimpaired, healthy older individuals. Notable methodological limitations across investigations might mask the lack of effects., (© 2023. The Author(s), under exclusive licence to American Aging Association.)- Published
- 2024
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29. Chia nanoemulsion: anti-inflammatory mechanism, biological behavior and cellular interactions.
- Author
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Correa LB, Gomes-da-Silva NC, Dos Santos CC, Rebelo Alencar LM, Graças Muller de Oliveira Henriques MD, Bhattarai P, Zhu L, Noronha Souza PF, Rosas EC, and Santos-Oliveira R
- Abstract
Aim: This study explores chia oil, rich in ω-3 fatty acids and nutraceutical components, as a potential remedy for diseases, especially those linked to inflammation and cancer. Methods/materials: A chia oil-based nanoemulsion, developed through single emulsification, underwent comprehensive analysis using various techniques. In vitro and in vivo assays, including macrophage polarization, nitrite and cytokine production, cellular uptake and biodistribution, were conducted to assess the anti-inflammatory efficacy. Results & conclusion: Results reveal that the chia nanoemulsion significantly inhibits inflammation, outperforming pure oil with twice the efficacy. Enhanced uptake by macrophage-like cells and substantial accumulation in key organs indicate its potential as an economical and effective anti-inflammatory nanodrug, addressing global economic and health impacts of inflammation-related diseases.
- Published
- 2024
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30. Micellar solution of [ 223 Ra]RaCl 2 : Reaching renal excretion, potent efficacy in osteoblastic osteosarcoma in PDX model, biochemistry alterations and pharmacokinetics.
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Pijeira MSO, Gomes-da-Silva NC, Ricci-Junior E, Alencar LMR, İlem-Özdemir D, Cavalcanti ADS, Machado DE, Perini JA, and Santos-Oliveira R
- Subjects
- Humans, Male, Animals, Mice, Radiopharmaceuticals pharmacokinetics, Tissue Distribution, Renal Elimination, Bone Neoplasms drug therapy, Bone Neoplasms radiotherapy, Osteosarcoma drug therapy, Prostatic Neoplasms, Castration-Resistant pathology
- Abstract
Despite the successful use of the radiopharmaceutical radium-223 dichloride ([
223 Ra]RaCl2 ) for targeted alpha therapy of castration-resistant prostate cancer patients with bone metastases, some short-term side effects, such as diarrhea and vomiting, have been documented, causing patient discomfort. Hence, we prepared a nanosized micellar solution of [223 Ra]RaCl2 and evaluated its biodistribution, pharmacokinetics, and induced biochemical changes in healthy mice up to 96 h after intraperitoneal administration as an alternative to overcome the previous limitations. In addition, we evaluated the bone specificity of micellar [223 Ra]RaCl2 in patient-derived xenografts in the osteosarcoma model. The biodistribution studies revealed the high bone-targeting properties of the micellar [223 Ra]RaCl2 . Interestingly, the liver uptake remained significantly low (%ID/g = 0.1-0.02) from 24 to 96 h after administration. In addition, the micellar [223 Ra]RaCl2 exhibited a significantly higher uptake in left (%ID/g = 0.85-0.23) and right (%ID/g = 0.76-0.24) kidneys than in small (%ID/g = 0.43-0.06) and large intestines (%ID/g = 0.24-0.09) over time, suggesting its excretion pathway is primarily through the kidneys into the urine, in contrast to the non-micellar [223 Ra]RaCl2 . The micellar [223 Ra]RaCl2 also had low distribution volume (0.055 ± 0.003 L) and longer elimination half-life (28 ± 12 days). This nanosystem was unable to change the enzymatic activities of alanine aminotransferase, aspartate aminotransferase, gamma GT, glucose, and liquiform lipase in the treated mice. Finally, microscopic examination of the animals' osteosarcoma tumors treated with micellar [223 Ra]RaCl2 indicated regression of the tumor, with large areas of necrosis. In contrast, in the control group, we observed tumor cellularity and cell anaplasia, mitotic figures and formation of neoplastic extracellular bone matrix, which are typical features of osteosarcoma. Therefore, our findings demonstrated the efficiency and safety of nanosized micellar formulations to minimize the gastrointestinal excretion pathway of the clinical radiopharmaceutical [223 Ra]RaCl2 , in addition to promoting regression of the osteosarcoma. Further studies must be performed to assess dose-response outcomes and organ/tissue dosimetry for clinical translation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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31. Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry.
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Flores-Lujano J, Allende-López A, Duarte-Rodríguez DA, Alarcón-Ruiz E, López-Carrillo L, Shamah-Levy T, Cebrián ME, Baños-Lara MDR, Casique-Aguirre D, Elizarrarás-Rivas J, López-Aquino JA, Garrido-Hernández MÁ, Olvera-Caraza D, Terán-Cerqueda V, Martínez-José KB, Aristil-Chery PM, Alvarez-Rodríguez E, Herrera-Olivares W, Ruíz-Arguelles GJ, Chavez-Aguilar LA, Márquez-Toledo A, Cano-Cuapio LS, Luna-Silva NC, Martínez-Martell MA, Ramirez-Ramirez AB, Merino-Pasaye LE, Galván-Díaz CA, Medina-Sanson A, Gutiérrez-Rivera ML, Martín-Trejo JA, Rodriguez-Cedeño E, Bekker-Méndez VC, Romero-Tlalolini MLÁ, Cruz-Maza A, Juárez-Avendaño G, Pérez-Tapia SM, Rodríguez-Espinosa JC, Suárez-Aguirre MC, Herrera-Quezada F, Hernández-Díaz A, Galván-González LA, Mata-Rocha M, Olivares-Sosa AI, Rosas-Vargas H, Jiménez-Morales S, Cárdenas-González M, Álvarez-Buylla Roces ME, Duque-Molina C, Pelayo R, Mejía-Aranguré JM, and Núñez-Enriquez JC
- Abstract
Introduction: Acute leukemias (AL) are the main types of cancer in children worldwide. In Mexico, they represent one of the main causes of death in children under 20 years of age. Most of the studies on the incidence of AL in Mexico have been developed in the urban context of Greater Mexico City and no previous studies have been conducted in the central-south of the country through a population-based study. The aim of the present work was to identify the general and specific incidence rates of pediatric AL in three states of the south-central region of Mexico considered as some of the marginalized populations of Mexico (Puebla, Tlaxcala, and Oaxaca)., Methods: A population-based study was conducted. Children aged less than 20 years, resident in these states, and newly diagnosed with AL in public/private hospitals during the period 2021-2022 were identified. Crude incidence rates (cIR), standardized incidence rates (ASIRw), and incidence rates by state subregions (ASIRsr) were calculated. Rates were calculated using the direct and indirect method and reported per million children under 20 years of age. In addition, specific rates were calculated by age group, sex, leukemia subtype, and immunophenotype., Results: A total of 388 cases with AL were registered. In the three states, the ASIRw for AL was 51.5 cases per million (0-14 years); in Puebla, it was 53.2, Tlaxcala 54.7, and Oaxaca de 47.7. In the age group between 0-19 years, the ASIRw were 44.3, 46.4, 48.2, and 49.6, in Puebla, Tlaxcala, and Oaxaca, respectively. B-cell acute lymphoblastic leukemia was the most common subtype across the three states., Conclusion: The incidence of childhood AL in the central-south region of Mexico is within the range of rates reported in other populations of Latin American origin. Two incidence peaks were identified for lymphoblastic and myeloid leukemias. In addition, differences in the incidence of the disease were observed among state subregions which could be attributed to social factors linked to the ethnic origin of the inhabitants. Nonetheless, this hypothesis requires further investigation., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that authors JN-E, RP and JM-A were all Topic Editors and were members of Frontiers at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Flores-Lujano, Allende-López, Duarte-Rodríguez, Alarcón-Ruiz, López-Carrillo, Shamah-Levy, Cebrián, Baños-Lara, Casique-Aguirre, Elizarrarás-Rivas, López-Aquino, Garrido-Hernández, Olvera-Caraza, Terán-Cerqueda, Martínez-José, Aristil-Chery, Alvarez-Rodríguez, Herrera-Olivares, Ruíz-Arguelles, Chavez-Aguilar, Márquez-Toledo, Cano-Cuapio, Luna-Silva, Martínez-Martell, Ramirez-Ramirez, Merino-Pasaye, Galván-Díaz, Medina-Sanson, Gutiérrez-Rivera, Martín-Trejo, Rodriguez-Cedeño, Bekker-Méndez, Romero-Tlalolini, Cruz-Maza, Juárez-Avendaño, Pérez-Tapia, Rodríguez-Espinosa, Suárez-Aguirre, Herrera-Quezada, Hernández-Díaz, Galván-González, Mata-Rocha, Olivares-Sosa, Rosas-Vargas, Jiménez-Morales, Cárdenas-González, Álvarez-Buylla Roces, Duque-Molina, Pelayo, Mejía-Aranguré and Núñez-Enriquez.)
- Published
- 2024
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32. Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action.
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Gomes-da-Silva NC, Corrêa LB, González MM, Silva França ÁR, Rebelo Alencar LM, Rosas EC, Ricci-Junior E, Borges Aguiar TK, Noronha Souza PF, and Santos-Oliveira R
- Abstract
Introduction: Nanoceria is a well-known nanomaterial with various properties, including antioxidant, proangiogenic, and therapeutic effects. Despite its potential, there are still aspects that require further exploration, particularly its anti-inflammatory and antimicrobial activities., Method: The global demand for novel anti-inflammatory and antimicrobial drugs underscores the significance of understanding nanoceria in both contexts. In this study, we evaluated the effect of nanoceria on macrophage polarization to better understand its anti-inflammatory effects. Additionally, we investigated the mechanism of action of nanoceria against Cryptococcus neoformans (ATCC 32045), Candida parapsilosis (ATCC 22019), Candida krusei (ATCC 6258), and Candida albicans., Result: The results demonstrated that nanoceria can polarize macrophages toward an anti-inflammatory profile, revealing the cellular mechanisms involved in the anti-inflammatory response. Concerning the antimicrobial effect, it was observed that nanoceria have a more pronounced impact on Candida parapsilosis, leading to the formation of pronounced pores on the surface of this species., Conclusion: Finally, biochemical analysis revealed transitory alterations, mainly in liver enzymes. The data support the use of nanoceria as a potential anti-inflammatory and antimicrobial drug and elucidate some of the mechanisms involved, shedding light on the properties of this nanodrug., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2024
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33. Cross-sectional and longitudinal neural predictors of physical activity and sedentary behaviour from a 6-month randomized controlled trial.
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Falck RS, Hsu CL, Best JR, Boa Sorte Silva NC, Hall PA, Li LC, and Liu-Ambrose T
- Subjects
- Adult, Humans, Cross-Sectional Studies, Pleasure, Executive Function, Exercise, Sedentary Behavior
- Abstract
A sedentary lifestyle offers immediate gratification, but at the expense of long-term health. It is thus critical to understand how the brain evaluates immediate rewards and long-term health effects in the context of deciding whether to engage in moderate-to-vigorous physical activity (MVPA) or sedentary behaviour (SB). In this secondary analysis of a 6-month randomized controlled trial to increase MVPA and reduce SB among community-dwelling adults, we explored how neural activity during an executive control task was associated with MVPA and SB levels. At baseline, a subset of participants (n = 26/61) underwent task-based functional magnetic resonance imaging (fMRI) to examine neural activity underlying executive control using the Now/Later task. MVPA and SB were measured objectively using the Sensewear Mini at baseline, and 2, 4, and 6 months follow-up. We then examined the associations of baseline neural activation underlying executive control with: (1) baseline MVPA or SB; and (2) changes in MVPA and SB over 6 months. Our results determined that there is a complex neurocognitive system associated with MVPA levels, while SB appears to lack any neurocognitive control. In other words, MVPA appears to require neurocognitive effort, while SB may be the default behavioural pattern in adults., (© 2023. The Author(s).)
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- 2024
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34. Subclassification of B-acute lymphoblastic leukemia according to age, immunophenotype and microenvironment, predicts MRD risk in Mexican children from vulnerable regions.
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Romo-Rodríguez R, Zamora-Herrera G, López-Blanco JA, López-García L, Rosas-Cruz A, Alfaro-Hernández L, Trejo-Pichardo CO, Alberto-Aguilar DR, Casique-Aguirre D, Vilchis-Ordoñez A, Solis-Poblano JC, García-Stivalet LA, Terán-Cerqueda V, Luna-Silva NC, Garrido-Hernández MÁ, Cano-Cuapio LS, Ayala-Contreras K, Domínguez F, Del Campo-Martínez MLÁ, Juárez-Avendaño G, Balandrán JC, Pérez-Tapia SM, Fernández-Giménez C, Zárate-Rodríguez PA, López-Aguilar E, Treviño-García A, Duque-Molina C, Bonifaz LC, Núñez-Enríquez JC, Cárdenas-González M, Álvarez-Buylla ER, Ramírez-Ramírez D, and Pelayo R
- Abstract
Introduction: The decisive key to disease-free survival in B-cell precursor acute lymphoblastic leukemia in children, is the combination of diagnostic timeliness and treatment efficacy, guided by accurate patient risk stratification. Implementation of standardized and high-precision diagnostic/prognostic systems is particularly important in the most marginalized geographic areas in Mexico, where high numbers of the pediatric population resides and the highest relapse and early death rates due to acute leukemias are recorded even in those cases diagnosed as standard risk., Methods: By using a multidimensional and integrated analysis of the immunophenotype of leukemic cells, the immunological context and the tumor microenvironment, this study aim to capture the snapshot of acute leukemia at disease debut of a cohort of Mexican children from vulnerable regions in Puebla, Oaxaca and Tlaxcala and its potential use in risk stratification., Results and Discussion: Our findings highlight the existence of a distinct profile of ProB-ALL in children older than 10 years, which is associated with a six-fold increase in the risk of developing measurable residual disease (MRD). Along with the absence of CD34
+ seminal cells for normal hematopoiesis, this ProB-ALL subtype exhibited several characteristics related to poor prognosis, including the high expression level of myeloid lineage markers such as MPO and CD33, as well as upregulation of CD19, CD34, CD24, CD20 and nuTdT. In contrast, it showed a trend towards decreased expression of CD9, CD81, CD123, CD13, CD15 and CD21. Of note, the mesenchymal stromal cell compartment constituting their leukemic niche in the bone marrow, displayed characteristics of potential suppressive microenvironment, such as the expression of Gal9 and IDO1, and the absence of the chemokine CXCL11. Accordingly, adaptive immunity components were poorly represented. Taken together, our results suggest, for the first time, that a biologically distinct subtype of ProB-ALL emerges in vulnerable adolescents, with a high risk of developing MRD. Rigorous research on potential enhancing factors, environmental or lifestyle, is crucial for its detection and prevention. The use of the reported profile for early risk stratification is suggested., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Romo-Rodríguez, Zamora-Herrera, López-Blanco, López-García, Rosas-Cruz, Alfaro-Hernández, Trejo-Pichardo, Alberto-Aguilar, Casique-Aguirre, Vilchis-Ordoñez, Solis-Poblano, García-Stivalet, Terán-Cerqueda, Luna-Silva, Garrido-Hernández, Cano-Cuapio, Ayala-Contreras, Domínguez, del Campo-Martínez, Juárez-Avendaño, Balandrán, Pérez-Tapia, Fernández-Giménez, Zárate-Rodríguez, López-Aguilar, Treviño-García, Duque-Molina, Bonifaz, Núñez-Enríquez, Cárdenas-González, Álvarez-Buylla, Ramírez-Ramírez and Pelayo.)- Published
- 2024
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35. Gasoline discrimination using infrared spectroscopy and virtual samples based on measurement uncertainty.
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Sales RF, Cássio Barbosa-Patrício L, da Silva NC, Rodrigues E Brito L, Eduarda Fernandes da Silva M, and Fernanda Pimentel M
- Abstract
In a previous work, we proposed a methodology for pair-wise discrimination of gasoline samples by creating virtual samples based on physicochemical assays or distillation curves. Satisfactory results were achieved, although specialist and specific apparatus (not commonly available at police laboratories) were required. The present study goes a step further and for the first time investigates the possibility of infrared (IR) spectroscopy to enable a virtual samples-based methodology for comparison of gasoline samples in pairs. IR spectroscopy feasibility for in situ applications is attractive for forensic investigations. The performances of one handheld NIR device and one dual-range (FT-NIR and FT-IR) benchtop spectrometer were evaluated. The estimation of uncertainty in infrared spectral measurement (needed to generate virtual samples) is barely discussed in literature. So far, there are no literature reports describing quantification and comparison of measurement uncertainties for the spectral acquisitions evaluated here, especially regarding their use for generating virtual samples. A stepwise procedure to quantify uncertainties associated with IR spectral acquisition, at each wavenumber, is described. This method can be useful for understanding both the sources of variability in IR measurements and the system under investigation. Uncertainty estimation was based on experimental data and considered intermediate precision, repeatability and variations in sample temperature as sources of variability. Virtual samples were employed in a discrimination approach using SIMCA models. Results for portable NIR, FT-NIR and FT-IR data sets showed complete discrimination for 96.3%, 93.4% and 93.7% of the 1431 pairs of gasoline samples evaluated, respectively. These results were comparable and similar to those obtained for the physicochemical properties data set (95.7%), although slightly inferior to the result obtained for distillation curves (99.2%). Using IR non-destructive methods in this case could enable faster investigations and simpler analysis, especially for the low-cost handheld spectrometer. In a screening approach, atmospheric distillation assays can be employed only if infrared techniques are not capable of distinguishing the samples subject to comparison. In this work, a pair of samples was considered to be completely discriminated only when a null false positive error (FPR) was achieved, although a more flexible criterium may be acceptable in practice. Finally, the methodology could be extended to other applications where sample comparison is important., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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36. Data2MV - A user behaviour dataset for multi-view scenarios.
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da Costa TS, Andrade MT, Viana P, and Silva NC
- Abstract
The Data2MV dataset contains gaze fixation data obtained through experimental procedures from a total of 45 participants using an Intel RealSense F200 camera module and seven different video playlists. Each of the playlists had an approximate duration of 20 minutes and was viewed at least 17 times, with raw tracking data being recorded with a 0.05 second interval. The Data2MV dataset encompasses a total of 1.000.845 gaze fixations, gathered across a total of 128 experiments. It is also composed of 68.393 image frames, extracted from each of the 6 videos selected for these experiments, and an equal quantity of saliency maps, generated from aggregate fixation data. Software tools to obtain saliency maps and generate complementary plots are also provided as an open-source software package. The Data2MV dataset was publicly released to the research community on Mendeley Data and constitutes an important contribution to reduce the current scarcity of such data, particularly in immersive, multi-view streaming scenarios., (© 2023 The Authors. Published by Elsevier Inc.)
- Published
- 2023
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37. Language skills development in children with congenital Zika virus syndrome.
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da Silva NC, Pinato L, Ribeiro EM, and Giacheti CM
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- Humans, Longitudinal Studies, Language Development, Cognition, Language, Zika Virus, Zika Virus Infection complications, Zika Virus Infection epidemiology
- Abstract
Background: The characterization of the phenotype of children with congenital Zika virus syndrome (CZS) is an ongoing process, since many characteristics can only be described with the advancing age of children providing some insights into the long-term sequelae., Aims: To describe emerging findings on the impact of CZS on language development in children with CZS in a 4-year longitudinal study., Methods and Procedures: 39 boys and 44 girls with CZS were allocated into four groups according to age ranging from 12 to 36 months. Language development was assessed using the Early Language Milestone Scale., Outcomes and Results: Visual, expressive, and receptive auditory skills of patients were lower than expected for their age. Despite producing vowel sounds, they did not babble; despite present hearing, the majority of the children did not understand simple commands. In over 4 years of follow-up, there was no evolution in language parameters, with the children stagnating at the language skills corresponding to 3 months of age., Conclusions and Implications: Most children with CZS are not able to produce vocalic sounds, but some may be able to communicate basic needs through alternative communication. WHAT THIS PAPER ADDS?: Some babies with CZS died prenatally, at birth, or in the first year of life due to associated complications such as respiratory infection, dysphagia, and epilepsy. However, the functionality of the future remains uncertain for surviving babies. This study adds information about the impact of Zika Virus on the central nervous system and, consequently, the severity and complexity of the CZS language. Over 4 years of follow-up, no evolution in language parameters was observed in children with CSZ. Children with CZS demonstrate severe neurodevelopmental impairment, stagnating in language skills at the age of 3 months. In the future, some of them may be able to communicate their basic needs through alternative communication., Competing Interests: Declaration of competing interest None., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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38. Effects of Infrared and Microwave Radiation on the Bioactive Compounds of Microalga Spirulina platensis after Continuous and Intermittent Drying.
- Author
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Silva NC, Graton IS, Duarte CR, and Barrozo MAS
- Subjects
- Microwaves, Citric Acid, Spirulina, Microalgae
- Abstract
Pharmaceutical, nutritional and food industries have recently become interested in the potential of Spirulina platensis , a kind of cyanobacterium with high levels of proteins, vitamins and bioactive compounds. Because of its high moisture, this microalga needs to be submitted to a preservation technique such as drying to be properly used. The aim of this work is to investigate the use of infrared and microwave radiation in the Spirulina platensis drying process. The experiments were performed in continuous and intermittent modes, evaluating different operating conditions for infrared and microwave drying, as well as their effects on the quality of the final product, expressed by the content of bioactive compounds (i.e., total phenolic, total flavonoid, citric acid and phycocyanin contents). The results proved that the use of electromagnetic radiation in the drying of spirulina is an interesting alternative for processing this material if performed under adequate operating conditions. The experiments carried out continuously at lower temperatures and powers and the combination between different temperatures and powers in the intermittent mode resulted in a final product with satisfactory levels of bioactive compounds and low operation times in comparison with conventional methodologies.
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- 2023
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39. Proteomic profile of the acquired enamel pellicle of children with early childhood caries and caries-free children.
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Oliveira BP, Buzalaf MAR, Silva NC, Ventura TMO, Toniolo J, and Rodrigues JA
- Subjects
- Child, Preschool, Humans, Dental Pellicle metabolism, Proteomics, Cross-Sectional Studies, Phosphoproteins metabolism, Proline metabolism, Salivary Proteins and Peptides metabolism, Saliva, Tandem Mass Spectrometry, Dental Caries
- Abstract
Acquired enamel pellicle plays an important role in the pathogenesis of early childhood caries (ECC), working as a protective interface between the tooth and the oral cavity. The aim of this cross-sectional in vivo proteomic study was to compare the acquired enamel pellicle protein profile of 3-5-year-old children with ECC (n = 10) and caries-free children (n = 10). Acquired enamel pellicle samples were collected and processed for proteomic analysis (nLC-ESI-MS/MS). In total, 241 proteins were identified. Basic salivary proline-rich protein 1 and 2, Cystatin-B, and SA were found only in the caries free group. When comparing caries free and ECC groups, lower protein levels were found in the caries free group for hemoglobin subunit beta, delta, epsilon, gamma-2, globin domain-containing protein and gamma-1, neutrophil defensin 3, serum albumin, protein S100-A8, and S100-A9. The proteins histatin-1, statherin, salivary acidic proline-rich phosphoprotein ½, proline-rich protein 4, submaxillary gland androgen-regulated protein 3B, alpha-amylase 1 and 2B were found at higher levels in the caries free group. The exclusive and the proteins found at higher levels in the caries free group might have protective functions that play a role in the prevention of caries, besides providing important insights to be evaluated in future studies for the possible development of new therapeutic strategies for ECC., (© 2023 Scandinavian Division of the International Association for Dental Research. Published by John Wiley & Sons Ltd.)
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- 2023
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40. Obstructive sleep apnea and orofacial myofunctional aspects in obesity.
- Author
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da Silva NC, da Silva GPJT, Onofri SMM, and Pinato L
- Subjects
- Male, Adult, Female, Humans, Overweight, Snoring, Obesity epidemiology, Body Mass Index, Sleep Apnea, Obstructive diagnosis, Sleep Apnea, Obstructive epidemiology, Airway Obstruction
- Abstract
Purpose: This study aimed to evaluate the quality of sleep, presence of obstructive sleep apnea (OSA), and its relationship with the presence of snoring, cephalometric characteristics, degree of collapse of the upper airways, and orofacial myofunctional profile in obese and overweight individuals., Methods: All participants completed polysomnography, as well as sleep and snoring questionnaires. We further performed orofacial, otorhinolaryngological, and anthropometric evaluations on all participants., Results: A total of 102 adults, comprising 29 obese, 21 overweight, and 52 eutrophic individuals of both sexes participated in this study. We observed a high prevalence of snoring in both obese and overweight (100%), and in 65% of eutrophic individuals. Among the obese subjects 58% had a severe degree of OSA, whereas 4% of eutrophic subjects presented a risk for OSA development. Sleep quality was related to body mass index (BMI) and cervical and abdominal circumference. All obese and overweight individuals presented with orofacial myofunctional alterations such as facial asymmetry, alteration of the maxilla-jaw relationship, inadequate tongue posture, changes in masticatory pattern and swallowing, and inadequate general orofacial myofunctional condition. Airway obstructions at the retropalatal and retrolingual levels > 75% were observed in at least 48% of the individuals., Conclusion: Obese and overweight individuals presented a higher risk for the development of OSA compared with eutrophic patients, and obese individuals presented a greater severity of OSA. The higher the BMI and greater the cervical and abdominal circumferences, the higher the prevalence of OSA, worse the quality of sleep, and more serious orofacial myofunctional characteristics in this population., (© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
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- 2023
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41. Methyl gallate nanomicelles impairs neutrophil accumulated in zymosan-induced arthritis.
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Pereira LM, Gomes-da-Silva NC, Pijeira MSO, Portilho FL, Cordeiro AS, Alencar LMR, Corrêa LB, Henriques MDG, Santos-Oliveira R, and Rosas EC
- Subjects
- Mice, Animals, Humans, Neutrophils, Zymosan adverse effects, Tissue Distribution, Inflammation chemically induced, Inflammation drug therapy, Arthritis, Experimental chemically induced, Arthritis, Experimental drug therapy, Disabled Persons, Motor Disorders
- Abstract
Arthritis is a chronic disease that affects, approximately, 1 % of the total global population. It is characterized by chronic inflammation, accompanied in most of the cases of motor disability and sever pain. The main therapies available have high risk of failure and advanced treatments are scarce and highly cost. In this scenario, search for effective, safe and low-cost treatments is quite desirable. Methyl gallate (MG) is a plant-derived phenolic compound described to present remarkable anti-inflammatory effect in experimental models of arthritis. Thus, in this study we formulated nanomicelles of MG using Pluronic (F-127) as matrix and evaluated in vivo the pharmacokinetic, biodistribution and its effect in the mice model of zymosan-induced arthritis. The nanomicelles were formed with a size 126 nm. The biodistribution showed a ubiquitous tissue deposition with a renal excretion. The pharmacokinetics showed elimination half-life of 1.72 h and a clearance of 0.006 L/h. The oral pretreatment with nanomicelles containing MG (3.5 or 7 mg/kg) demonstrated a reduction in total leukocytes, neutrophils, and mononuclear cells from the inflammation site. The data supports the use of methyl gallate nanomicelles as an alternative drug for arthritis. DATA AVAILABILITY: All the data of this study are transparent., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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42. Oral candidiasis in patients hospitalised in the intensive care unit: Diagnosis through clinical and cytopathological examinations.
- Author
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Dos Santos Freire FM, Marques LC, da Silva NC, Cunha KS, Conde DC, Milagres A, Gonçalves LS, and Junior AS
- Subjects
- Humans, Prospective Studies, Creatinine, Intensive Care Units, Candidiasis, Oral diagnosis, Candidiasis, Oral epidemiology, Candidiasis diagnosis, Candidiasis epidemiology
- Abstract
Objective: To evaluate the prevalence and clinical aspects of oral candidiasis in patients hospitalised in the intensive care unit., Methods: This is a longitudinal and prospective study that included 48 participants hospitalised in the intensive care unit. Sociodemographic data, presence of systemic disorders, use of medications, laboratory tests, cause of hospital admission, type of breathing, and length of hospital stay were obtained from medical records. Oral clinical inspection and cytopathological examinations were performed on all participants. The diagnosis of clinical candidiasis was based on the presence of clinical alterations together with positive cytopathological examination results. The diagnosis of subclinical candidiasis was based on the absence of clinical lesions and a positive cytopathological examination. The absence of oral candidiasis was considered when the participant did not present oral lesions and had a negative cytopathological examination., Results: Clinical candidiasis was present in 18.8% of the 48 participants, and 45.8% of them had the subclinical form. Levels of urea (P = 0.005), creatinine (P = 0.009), haemoglobin (P = 0.009), haematocrit (P = 0.011), bands (P = 0.024), international normalised ratio (INR; P = 0.034), types of breathing (P = 0.017), length of hospital stay (P = 0.037), and outcome (P = 0.014) demonstrated statistically significant differences between the groups with and without oral candidiasis., Conclusions: Clinical and subclinical forms of oral candidiasis are frequent in intensive care unit patients. Levels of urea, creatinine, haemoglobin, haematocrit, bands, INR, type of breathing, length of hospital stay, and outcome can be associated with the presence of candidiasis., (© 2023 John Wiley & Sons Ltd.)
- Published
- 2023
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43. Effect of the dietary inflammatory potential on the trajectory of body adiposity in a Brazilian cohort of university students.
- Author
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de Souza APA, Paravidino VB, Sichieri R, Pereira RA, da Silva NC, Rodrigues PRM, Muraro AP, and Ferreira MG
- Subjects
- Male, Humans, Female, Brazil epidemiology, Cohort Studies, Universities, Body Mass Index, Diet, Students, Risk Factors, Adiposity, Obesity
- Abstract
Objectives: University students are vulnerable to unhealthy eating habits that characterize a proinflammatory diet. This study aimed to estimate the dietary inflammatory index (DII) and its association with the trajectory of body adiposity markers in university students., Methods: The study analyzed data from 685 students entering a Brazilian public university in 2016 and 2017 and followed until 2018. DII was estimated from 39 dietary parameters obtained by 24-h dietary recall. Body adiposity was assessed by anthropometric markers and the percentage of body fat. Linear mixed-effects models were used to estimate the trajectory of adiposity markers according to DII tertiles., Results: After adjustment for confounding variables, at baseline, DII showed a positive association with increased percentage of body fat among men (β = 0.52; 95% CI: 0.01; 1.03) and waist-to-height ratio (WHtR; β = 0.15; 95% CI: 0.12; 0.18) and among women with all body adiposity markers: BMI (β = 0.68; 95% CI: 0.30; 1.05), percentage of body fat (β = 1.43; 95% CI: 0.74; 2.11), WC (β = 1.15; 95% CI: 0.41; 1.89) and WHtR (β = 0.13; 95% CI:0,10; 0.16). The rate of change of the outcome variables over time was not associated with DII at baseline., Conclusions: The diet of university students in this Brazilian cohort study was characterized as proinflammatory and it was associated with body adiposity markers., (© 2023 Wiley Periodicals LLC.)
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- 2023
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44. Urinary Aspergillosis in a Patient with Systemic Lupus Erythematosus (SLE).
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Toledo MG, Alves HR, Cambruzzi I, Pires LL, Rossi M, Gonçalves Brito AC, D'Avila Freitas A, and Zambão da Silva NC
- Abstract
Aspergillosis is an opportunistic mycosis that generally affects the lungs. The fungus was cleared by the immune system of a healthy host. Extrapulmonary forms are very rare, and there are few reports of urinary aspergillosis. In this case report, we describe a 62-year-old woman with systemic lupus erythematosus (SLE) with complaints of fever and dysuria. The patient had recurrent episodes of urinary tract infection and several hospitalizations. A computed tomography revealed an amorphous mass in the left kidney and bladder. After partial resection of the material was referred for analysis, Aspergillus infection was suspected and confirmed by culture. Successful treatment with voriconazole was provided. Diagnosis of localized primary renal Aspergillus infection in a patient with SLE requires careful investigation due to its benign presentation and lack of associated systemic clinical features., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2023 Mayara Gabriele Toledo et al.)
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- 2023
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45. Dissemination of methicillin-resistant Staphylococcus aureus USA300 ST8/PVL- positive in breast infections in a Brazilian region.
- Author
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Silva NC, de Souza MC, Tonini MAL, and Schuenck RP
- Subjects
- Humans, Brazil epidemiology, Exotoxins genetics, Leukocidins genetics, Molecular Epidemiology, DNA, Bacterial genetics, Methicillin-Resistant Staphylococcus aureus genetics, Staphylococcal Infections epidemiology
- Abstract
We aimed to analyze the molecular epidemiology of 46 methicillin-resistant Staphylococcus aureus (MRSA) isolated from breast infections. The USA300 lineage carrying SCCmecIVa, arginine catabolic mobile element, t008, ST8, and Panton-Valentine leukocidin genes was predominant (93%). This is the first study that describes the spread of the USA300 methicillin-resistant Staphylococcus aureus clone in breast infections in Brazil., Competing Interests: Declaration of competing interests The authors report no conflicts of interest relevant to this article., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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46. Virulence and antimicrobial resistance genes profiles of spa type t605 methicillin-susceptible Staphylococcus aureus isolated from subclinical bovine mastitis.
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Munive Nuñez KV, da Silva Abreu AC, Gonçalves JL, Dos Santos MV, de Oliveira Rocha L, and Cirone Silva NC
- Subjects
- Animals, Cattle, Female, Staphylococcus aureus, Anti-Bacterial Agents pharmacology, Virulence genetics, Methicillin, Drug Resistance, Bacterial genetics, Brazil, Virulence Factors genetics, Microbial Sensitivity Tests, Mastitis, Bovine epidemiology, Staphylococcal Infections veterinary, Staphylococcal Infections epidemiology, Methicillin-Resistant Staphylococcus aureus
- Abstract
Aims: Staphylococcus aureus is one of the most common pathogens associated with mastitis in dairy herds worldwide. This study evaluated the profile of virulence and antimicrobial resistance genes of spa type t605 methicillin-susceptible Staphylococcus aureus isolated from subclinical bovine mastitis in São Paulo, Brazil., Methods and Results: A total of 57 S. aureus strains were screened by conventional PCR (Polymerase Chain Reaction) for 49 virulence genes. The most prevalent virulence genes detected were icaD (94.7%), fib (93%), fnbA (82.5%), clfA (80.7%), bap (78.9%), clfB (73.7%), icaA (66.7%), see (64.9%), and sed (61.4%). The blaZ (94.7%), aac6'aph2' (15.8%), and ant4 (12.3%) genes were the most common antimicrobial resistance genes; however, mecA and mecC genes were not found. All methicillin-susceptible S. aureus (MSSA) strains were characterized through spa and agr typing. The spa type t605 was found in all isolates. By agr typing, the most prevalent were type II (56.1%). Antimicrobial resistance was determined by the disk diffusion method, and 93% showed resistance to at least one antibiotic. Penicillin resistance was the most prevalent (87.7%), followed by tetracycline (12.3%), oxacillin (10.5%), and gentamicin (10.5%) resistance., Conclusion: Our study confirmed the spa type t605 as endemic, carrying a wide variety of virulence factors and high-level penicillin resistance. The profile seems to be associated with the colonization of MSSA and its persistence in subclinical mastitis., (© The Author(s) 2023. Published by Oxford University Press on behalf of Applied Microbiology International.)
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- 2023
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47. Validation of the HOSPITAL score as predictor of 30-day potentially avoidable readmissions in pediatric hospitalized population: retrospective cohort study.
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da Silva NC, Albertini MK, Backes AR, and das Graças Pena G
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- Adult, Adolescent, Humans, Child, Retrospective Studies, Risk Factors, Hospitals, University, Patient Readmission, Hospitalization
- Abstract
Potentially avoidable pediatric readmissions are a burden to patients and their families. Identifying patients with higher risk of readmission could help minimize hospital costs and facilitate the targeting of care interventions. HOSPITAL score is a tool developed and widely used to predict adult patient's readmissions; however its predictive capacity for pediatric readmissions has not yet been evaluated. The aim of the study was to validate the HOSPITAL score application to predict 30-day potentially avoidable readmissions in a pediatric hospitalized population. This is a retrospective cohort study with patients under 18 years old admitted to a tertiary university hospital (n = 6,344). The HOSPITAL score was estimated for each admission. Subsequently, we classified the patients as low (0-4), intermediate (5-6), and high (7-12) risk groups. In order to estimate the discrimination power, the sensitivity, specificity, and accuracy were determined by the receiver operating characteristics (ROC) and the calibration by the Hosmer-Lemeshow goodness-of-fit. The 30-day hospital readmission was 11.70% (745). The accuracy was 0.80 (CI 95%, 0.77, 0.83), with a sensitivity of 70.96% and specificity of 78.29%, and a good calibration (p = 0.34). Conclusion: HOSPITAL score showed a good discrimination and can be used to predict 30-day potentially avoidable readmission in a large pediatric population with different medical diagnoses. Our study validates and expands the usefulness of the HOSPITAL score as a tool to predict avoidable hospital readmissions for pediatric population. What is Known: • Pediatric readmissions burden patients, the family network, and the health system. In addition, it influences negatively child development. • The HOSPITAL score is one of the tools developed and widely used to identify patients at high risk of hospital readmission, but its predictive capacity for pediatric readmissions has not been yet assessed. What is New: • The HOSPITAL score showed good ability to identify a risk of 30-day potentially avoidable readmission in a pediatric population in different clinical contexts and diagnoses. • Our study expands the usefulness of the HOSPITAL score as a tool for predicting hospital readmissions for children and adolescents., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2023
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48. Saliva proteomic profile of early childhood caries and caries-free children.
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Oliveira BP, Buzalaf MAR, Silva NC, Ventura TMO, Toniolo J, and Rodrigues JA
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- Humans, Child, Preschool, Child, Saliva metabolism, Proteomics, Cariostatic Agents, Hemoglobin Subunits metabolism, Dental Caries
- Abstract
Objective: Saliva plays an important antimicrobial role and it is related to the pathogenesis of early childhood caries (ECC). The aim of this study was to compare the proteomic profile of unstimulated saliva of children aged 3-5 years who had ECC and caries-free (CF) children., Materials and Methods: After the saliva collection from 20 children (ECC: n = 10; CF: n = 10), the samples were processed for proteomic analysis on a mass spectrometer., Results: 1638 proteins were identified, of which 355 were present in both groups. A total of 579 proteins were exclusively identified in the CF group and included Leucine-rich alpha-2-glycoprotein, Protein S100-A5, Protein S100-A8 and Mucin-2. Moreover, 704 proteins were exclusively identified in the ECC group, including Enamelin. The differential expression analysis revealed that 112 proteins were up-regulated in the CF group. Among these proteins, we highlighted Hemoglobin subunit gamma-1 (343-fold increase), gamma-2 (336-fold increase) and alpha (40-fold increase)., Conclusions: The proteomic profile of the saliva varied substantially between the groups. Hemoglobin subunit gamma-1, gamma-2 and alpha may play a protective role in children with ECC. These proteins should be evaluated in future studies, because they may be possible good candidates to be included in anti-caries dental products.
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- 2023
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49. Aspects related to biofilm production and antifungal susceptibility of clinically relevant yeasts of the genus Trichosporon.
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Lara BR, de Camargo BB, Paula CR, Monari GPM, Garces HG, Arnoni MV, Silveira M, Gimenes VMF, Leite Junior DP, Bonfietti LX, Oliveira L, Melhem MSC, Auler M, Ramos RTB, Dias ALT, Silva NC, Moreira D, Richini-Pereira VB, Anversa L, and Ruiz LDS
- Subjects
- Humans, Animals, Antifungal Agents pharmacology, Antifungal Agents therapeutic use, Fluconazole pharmacology, Caspofungin, Itraconazole, Amphotericin B pharmacology, Biofilms, Microbial Sensitivity Tests veterinary, Trichosporon, Trichosporonosis microbiology, Trichosporonosis veterinary
- Abstract
Trichosporonosis corresponds to a systemic fungal disease that leads to high mortality rates and is frequently associated with medical devices. It affects immunosuppressed patients in particular and is strongly linked to acquired human immunodeficiency, organ and tissue transplants, and malignant hematologic diseases such as leukemia and lymphomas. Trichosporon infections have been increasingly reported worldwide; however, little information is available either about their characteristics or the causative microorganism. Thus, the aims of the present study were: to investigate 59 yeasts of the genus Trichosporon by verifying the biofilm formation capacity of isolates; to analyze the susceptibility patterns of planktonic cells against the antifungals fluconazole, itraconazole, amphotericin-B, voriconazole, and caspofungin by comparing European Committee for Antimicrobial Susceptibility Testing (EUCAST) broth microdilution technique with the commercial method Etest; and to assess the susceptibility patterns of biofilm cells (sessile) against the same antifungals through broth microdilution. The ability to form biofilm on the surface of polystyrene plates was noted for all isolates, and 54.3% of samples were considered strong producers. Comparison between the antifungal susceptibility techniques evidenced that Etest showed higher and discordant minimum inhibitory concentrations (MICs) from those obtained by the microdilution method, especially for fluconazole, itraconazole, and caspofungin. Considering the susceptibility of biofilms, most species had high MIC50 and MIC90 against the tested antifungals, showing 4-to-66-fold higher concentrations for amphotericin B and 2-to-33-fold greater concentrations for caspofungin. These results highlight the importance of further studies with Trichosporon spp. for comparison between laboratory findings and in vivo response, considering both the susceptibility tests and the behavior of biofilm cells against drugs., (© The Author(s) 2023. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.)
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- 2023
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50. Myelin and Physical Activity in Older Adults With Cerebral Small Vessel Disease and Mild Cognitive Impairment.
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Boa Sorte Silva NC, Dao E, Liang Hsu C, Tam RC, Lam K, Alkeridy W, Laule C, Vavasour IM, Stein RG, and Liu-Ambrose T
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- Humans, Female, Aged, Male, Myelin Sheath pathology, Cross-Sectional Studies, Magnetic Resonance Imaging, Cognitive Dysfunction complications, Cerebral Small Vessel Diseases complications
- Abstract
Background: Myelin loss is a feature of cerebral small vessel disease (cSVD). Although physical activity levels may exert protective effects over cSVD pathology, its specific relationship with myelin content in people living with the cSVD is unknown. Thus, we investigated whether physical activity levels are associated with myelin in community-dwelling older adults with cSVD and mild cognitive impairment., Methods: Cross-sectional data from 102 individuals with cSVD and mild cognitive impairment were analyzed (mean age [SD] = 74.7 years [5.5], 63.7% female). Myelin was measured using a magnetic resonance gradient and spin echo sequence. Physical activity was estimated using the Physical Activity Scale for the Elderly. Hierarchical regression models adjusting for total intracranial volume, age, sex, body mass index, and education were conducted to determine the associations between myelin content and physical activity. Significant models were further adjusted for white matter hyperintensity volume., Results: In adjusted models, greater physical activity was linked to higher myelin content in the whole-brain white matter (R2change = .04, p = .048). Greater physical activity was also associated with myelin content in the sagittal stratum (R2change = .08, p = .004), anterior corona radiata (R2change = .04, p = .049), and genu of the corpus callosum (R2change = .05, p = .018). Adjusting for white matter hyperintensity volume did not change any of these associations., Conclusions: Physical activity may be a strategy to maintain myelin in older adults with cSVD and mild cognitive impairment. Future randomized controlled trials of exercise are needed to determine whether exercise increases myelin content., (© The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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