Copper biomarkers and their relationship with parameters of insulin resistance in obese women.

Some studies have demonstrated the involvement of high concentrations of copper in the manifestation of insulin resistance in individuals with obesity. The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case-control clinical study involving 203 women aged between 20 and 50 years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p < 0.05) between groups. The study identified a significant positive correlation between plasma copper and fasting insulin values and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (p < 0.05). The results of this study demonstrate that obese women have high copper concentrations in plasma and lower concentrations in erythrocytes. Furthermore, the significant positive correlation between plasma copper and fasting insulin and HOMA-IR index suggests the influence of this mineral on glycemic control parameters in obese women.
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: The study was registered on Plataforma Brasil and approved by the Research Ethics Committee of the Federal University of Piauí, as provided for by Resolution 466/12 of the National Health Council (CNS) under Certificate of Presentation for Ethical Appreciation (CAAE) nº 3,774 0.163. All participants signed the Free and Informed Consent Form. Consent to Participant: Informed consent was obtained from all participating individuals included in the study. Consent for publication: Patients signed informed consent regarding publishing their data.
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