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7 results on '"Silke Reinecke"'

1. Synthesis of a Non-Symmetrical Disorazole C1-Analogue and Its Biological Activity

Author

Luca Lizzadro, Oliver Spieß, Silke Reinecke, Marc Stadler, and Dieter Schinzer

Subjects
non-symmetrical disorazole, convergent synthesis, biological activity, SAR (structure-activity-relationship), Organic chemistry, QD241-441
Abstract

The synthesis of a novel disorazole C1 analogue is described, and its biological activity as a cytotoxic compound is reported. Based on our convergent and flexible route to the disorazole core, we wish to report a robust strategy to synthesize a non-symmetrical disorazole in which we couple one half of the molecule containing the naturally occurring oxazole heterocycle and the second half of the disorazole macrocycle containing a thiazole heterocycle. This resulted in a very unusual non-symmetrical disorazole C1 analogue containing two different heterocycles, and its biological activity was studied. This provided exciting information about SAR (structure-activity-relationship) for this highly potent class of antitumor compounds.

Published
2024
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2. Elansolid A3, a Unique p ‐Quinone Methide Antibiotic from Chitinophaga sancti

Author

Andreas Kirschning, Heinrich Steinmetz, Rolf Müller, Silke Reinecke, Klaus Gerth, Wolfgang Kessler, and Rolf Jansen

Subjects
Grob fragmentation, Bacteria, Molecular Structure, medicine.drug_class, Organic Chemistry, Antibiotics, Microbial Sensitivity Tests, General Chemistry, Quinone methide, Catalysis, Anti-Bacterial Agents, chemistry.chemical_compound, chemistry, Chitinophaga sancti, medicine, Organic chemistry, Macrolides, Indolequinones
Published
2011
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6. Elansolid A, a unique macrolide antibiotic from Chitinophaga sancti isolated as two stable atropisomers

Author

Andreas Kirschning, Richard Dehn, Silke Reinecke, Klaus Gerth, Rolf Jansen, Nadin Schläger, Heinrich Steinmetz, and Rolf Müller

Subjects
Atropisomer, Magnetic Resonance Spectroscopy, medicine.drug_class, Stereochemistry, Chemistry, Antibiotics, Molecular Conformation, General Chemistry, Gram-Positive Bacteria, Catalysis, Anti-Bacterial Agents, Flexibacter, Isomerism, medicine, Chitinophaga sancti, Organic chemistry, Macrolides
Published
2010

7. Occupational airborne allergic contact dermatitis in a concrete repair worker

Author

Silke Reinecke, Johannes Geier, and Holger Lessmann

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Air Pollutants, Occupational, Dermatology, Risk Assessment, Severity of Illness Index, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Air pollutants, Occupational Exposure, Severity of illness, medicine, Humans, Immunology and Allergy, 030212 general & internal medicine, Allergic contact dermatitis, Desensitization (medicine), Construction Materials, Epoxy Resins, business.industry, Follow up studies, Allergens, Patch Tests, medicine.disease, Dermatitis, Occupational, Desensitization, Immunologic, Dermatitis, Allergic Contact, Occupational exposure, Risk assessment, business, Follow-Up Studies
Published
2009
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