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Synthesis of a Non-Symmetrical Disorazole C1-Analogue and Its Biological Activity
- Source :
- Molecules, Vol 29, Iss 5, p 1123 (2024)
- Publication Year :
- 2024
- Publisher :
- MDPI AG, 2024.
-
Abstract
- The synthesis of a novel disorazole C1 analogue is described, and its biological activity as a cytotoxic compound is reported. Based on our convergent and flexible route to the disorazole core, we wish to report a robust strategy to synthesize a non-symmetrical disorazole in which we couple one half of the molecule containing the naturally occurring oxazole heterocycle and the second half of the disorazole macrocycle containing a thiazole heterocycle. This resulted in a very unusual non-symmetrical disorazole C1 analogue containing two different heterocycles, and its biological activity was studied. This provided exciting information about SAR (structure-activity-relationship) for this highly potent class of antitumor compounds.
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 29
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2bc18fbb1ee4bd09024e1ead64d0a1b
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/molecules29051123