1. Analysis of microtubule dynamics using growth curve models
- Author
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Jammalamadaka, SR, Siddiqi, MA, and Ghosh, K
- Subjects
growth curves ,microtubule dynamics ,polynomial regression ,splines ,MANOVA ,Wilks' Lamda ,Acquired Cognitive Impairment ,Neurodegenerative ,Brain Disorders ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Aging ,Alzheimer's Disease ,Cancer ,Dementia ,Breast Cancer ,1.1 Normal biological development and functioning ,Generic Health Relevance ,Alzheimer's Disease including Alzheimer's Disease Related Dementias ,Statistics & Probability ,Statistics - Abstract
Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics. © 2009 Taylor & Francis.
- Published
- 2009