Upregulation of vascular endothelial growth factor (VEGF), its role in progression and prognosis of non-small cell lung carcinoma.

Authors :: Naikoo NA
Rasool R
Shah S
Ahangar AG
Siddiqi MA
Shah ZA
Source :: Cancer genetics [Cancer Genet] 2017 Oct; Vol. 216-217, pp. 67-73. Date of Electronic Publication: 2017 Jul 29.
Publication Year :: 2017
Abstract: Elevated VEGF mRNA (-ΔC <subscript>T</subscript> ) was significantly associated with adenocarcinoma histology (vs squamous) and advanced NSCLC clinical stages in a univariable analysis; however, this association did not remain significant in the multivariable analysis. Of interest, a Kaplan-Meier analysis showed that NSCLC patients with higher VEGF mRNA (-ΔC <subscript>T</subscript> ≥10) had a significantly poorer overall survival and shorter postoperative relapse time in adenocarcinoma and in stage III/IV than those with VEGF mRNA of -ΔC <subscript>T</subscript> <10 (P < 0.001). The multivariable analysis confirmed that patients with higher VEGF mRNA levels, as well as with adenocarcinoma and advanced stages, were independent predictors of a poorer survival. However, only the histology of adenocarcinoma remained a significant prognostic factor of a shorter postoperative relapse in the multivariable model. Quantity of VEGF mRNA can be used as a prognosis factor to predict shorter overall survival in patients with NSCLC.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)

Full Text Access

Tools