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3 results on '"Siang-Ee Lim"'

1. Suzuki-Miyaura cross-coupling reactions of primary alkyltrifluoroborates with aryl chlorides

Author

Dreher, Spencer D., Siang-Ee Lim, Sandrock, Deirde L., and Molander, Gary A.

Subjects
Bromides -- Chemical properties, Bromides -- Structure, Chlorides -- Chemical properties, Chlorides -- Structure, Dichloropropane -- Chemical properties, Dichloropropane -- Structure, Iodides -- Chemical properties, Iodides -- Structure, Biological sciences, Chemistry
Abstract

Parallel microscale experimentation is used for developing general conditions for the Suzuki-Miyaura cross-coupling of diversely functionalized primary alkyltrifluoroborates with a variety of aryl chlorides. The conditions obtained are amenable to coupling with aryl bromides, iodides and triflates.

Published
2009

2. ChemInform Abstract: Suzuki-Miyaura Cross-Coupling Reactions of Primary Alkyltrifluoroborates with Aryl Chlorides

Author

Deidre L. Sandrock, Spencer D. Dreher, Gary A. Molander, and Siang-Ee Lim

Subjects
chemistry.chemical_compound, Primary (chemistry), chemistry, Aryl, General Medicine, Combinatorial chemistry, Coupling reaction
Abstract

Parallel microscale experimentation was used to develop general conditions for the Suzuki−Miyaura cross-coupling of diversely functionalized primary alkyltrifluoroborates with a variety of aryl chlorides. These conditions were found to be amenable to coupling with aryl bromides, iodides, and triflates as well. The conditions that were previously identified through similar techniques to promote the cross-coupling of secondary alkyltrifluoroborates with aryl chlorides were not optimal for the primary alkyltrifluoroborates, thus demonstrating the value of parallel experimentation to develop novel, substrate specific results.

Published
2009
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3. Suzuki-Miyaura cross-coupling reactions of primary alkyltrifluoroborates with aryl chlorides

Author

Spencer D. Dreher, Deidre L. Sandrock, Gary A. Molander, and Siang-Ee Lim

Subjects
chemistry.chemical_compound, Primary (chemistry), Chlorides, Chemistry, Aryl, Organic Chemistry, Borates, Cross reactions, Organic chemistry, Indicators and Reagents, Ligands, Coupling reaction, Article
Abstract

Parallel microscale experimentation was used to develop general conditions for the Suzuki−Miyaura cross-coupling of diversely functionalized primary alkyltrifluoroborates with a variety of aryl chlorides. These conditions were found to be amenable to coupling with aryl bromides, iodides, and triflates as well. The conditions that were previously identified through similar techniques to promote the cross-coupling of secondary alkyltrifluoroborates with aryl chlorides were not optimal for the primary alkyltrifluoroborates, thus demonstrating the value of parallel experimentation to develop novel, substrate specific results.

Published
2009

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