1. Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus
- Author
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Yun Tao Wu, Lu Song, Xiao Xue Liu, Jing Sheng Gao, Xiao Ming Zheng, Chun Yu Ruan, Hai Yan Zhao, Shuo Hua Chen, Wen Yuan Gao, Jost B. Jonas, and Shou Ling Wu
- Subjects
Incident glucose tolerance impairment ,Incident diabetes ,Cumulative blood pressure exposure ,Kailuan study ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background With the marked increase in the prevalence of diabetes mellitus, it was the purpose of our study to assess a potential association of time-cumulated exposure to systolic (CumSBP) and of diastolic blood pressure (CumDBP) with onset of impaired glucose tolerance and diabetes mellitus. Methods The prospective investigation included participants of the longitudinal Kailuan Study with three baseline examinations in 2006–2007, 2008–2009 and 2010–2011, re-examination in 2012–2013, and no diabetes mellitus at baseline. Cumulative blood pressure (BP) was calculated as cumBP = [(BP1 + BP2)/2 × time1–2] + [(BP2 + BP3)/2 × time2–3]. Based on cumSBP, the study population was stratified into four groups (cumSBP
- Published
- 2017
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