76 results on '"Shokoohinia Y"'
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2. Grandivittin as a natural minor groove binder extracted from Ferulago macrocarpa to ct-DNA, experimental and in silico analysis
- Author
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Ahmadi, F., Valadbeigi, S., Sajjadi, S.E., Shokoohinia, Y., Azizian, H., and Taheripak, G.
- Published
- 2016
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3. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
- Author
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Kyu, H, Abate, D, Abate, K, Abay, S, Abbafati, C, Abbasi, N, Abbastabar, H, Abd-Allah, F, Abdela, J, Abdelalim, A, Abdollahpour, I, Abdulkader, R, Abebe, M, Abebe, Z, Abil, O, Aboyans, V, Abrham, A, Abu-Raddad, L, Abu-Rmeileh, N, Accrombessi, M, Acharya, D, Acharya, P, Ackerman, I, Adamu, A, Adebayo, O, Adekanmbi, V, Ademi, Z, Adetokunboh, O, Adib, M, Adsuar, J, Afanvi, K, Afarideh, M, Afshin, A, Agarwal, G, Agesa, K, Aggarwal, R, Aghayan, S, Agrawal, A, Ahmadi, A, Ahmadi, M, Ahmadieh, H, Ahmed, M, Ahmed, S, Aichour, A, Aichour, I, Aichour, M, Akinyemiju, T, Akseer, N, Al-Aly, Z, Al-Eyadhy, A, Al-Mekhlafi, H, Al-Raddadi, R, Alahdab, F, Alam, K, Alam, T, Alashi, A, Alavian, S, Alene, K, Alijanzadeh, M, Alizadeh-Navaei, R, Aljunid, S, Alkerwi, A, Alla, F, Allebeck, P, Alonso, J, Alsharif, U, Altirkawi, K, Alvis-Guzman, N, Aminde, L, Amini, E, Amiresmaili, M, Ammar, W, Amoako, Y, Anber, N, Andrei, C, Androudi, S, Animut, M, Anjomshoa, M, Ansha, M, Antonio, C, Anwari, P, Arabloo, J, Aremu, O, Arnlov, J, Arora, A, Arora, M, Artaman, A, Aryal, K, Asayesh, H, Ataro, Z, Ausloos, M, Avila-Burgos, L, Avokpaho, E, Awasthi, A, Ayala Quintanilla, B, Ayer, R, Azzopardi, P, Babazadeh, A, Badali, H, Balakrishnan, K, Bali, A, Banach, M, Banoub, J, Barac, A, Barboza, M, Barker-Collo, S, Barnighausen, T, Barquera, S, Barrero, L, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Behzadifar, M, Bekele, B, Bekru, E, Belachew, A, Belay, Y, Bell, M, Bello, A, Bennett, D, Bensenor, I, Berhane, A, Bernabe, E, Bernstein, R, Beuran, M, Beyranvand, T, Bhala, N, Bhatt, S, Bhaumik, S, Bhutta, Z, Biadgo, B, Biehl, M, Bijani, A, Bikbov, B, Bilano, V, Bililign, N, Bin Sayeed, M, Bisanzio, D, Bjorge, T, Bleyer, A, Bobasa, E, Bou-Orm, I, Boufous, S, Bourne, R, Brady, O, Brant, L, Brayne, C, Brazinova, A, Breitborde, N, Brenner, H, Briant, P, Briko, A, Britton, G, Brugha, T, Buchbinder, R, Busse, R, Butt, Z, Cahuana-Hurtado, L, Campuzano Rincon, J, Cano, J, Cardenas, R, Carrero, J, Carter, A, Carvalho, F, Castaneda-Orjuela, C, Rivas, J, Castro, F, Catala-Lopez, F, Cercy, K, Cerin, E, Chaiah, Y, Chang, J, Charlson, F, Chattu, V, Chiang, P, Chitheer, A, Choi, J, Christensen, H, Christopher, D, Chung, S, Cicuttini, F, Cirillo, M, Collado-Mateo, D, Cooper, C, Cortesi, P, Cortinovis, M, Cousin, E, Criqui, M, Cromwell, E, Cross, M, Crump, J, Daba, A, Dachew, B, Dadi, A, Dandona, L, Dandona, R, Dargan, P, Daryani, A, Das Gupta, R, Das Neves, J, Dasa, T, Davitoiu, D, De La Hoz, F, De Leo, D, De Neve, J, De Steur, H, Degefa, M, Degenhardt, L, Deiparine, S, Demoz, G, Denova-Gutierrez, E, Deribe, K, Dervenis, N, Des Jarlais, D, Dey, S, Dharmaratne, S, Dhimal, M, Dinberu, M, Dirac, M, Djalalinia, S, Doan, L, Dokova, K, Doku, D, Dorsey, E, Doyle, K, Driscoll, T, Dubey, M, Dubljanin, E, Duken, E, Duncan, B, Duraes, A, Ebrahimi, H, Ebrahimpour, S, Echko, M, Edessa, D, Edvardsson, D, Effiong, A, Eggen, A, Ehrlich, J, El Bcheraoui, C, El-Khatib, Z, Elyazar, I, Enayati, A, Endalifer, M, Endries, A, Er, B, Erskine, H, Eskandarieh, S, Esteghamati, A, Esteghamati, S, Fakhim, H, Faramarzi, M, Fareed, M, Farhadi, F, Farid, T, Sa Farinha, C, Farioli, A, Faro, A, Farzadfar, F, Fazaeli, A, Feigin, V, Fentahun, N, Fereshtehnejad, S, Fernandes, E, Fernandes, J, Ferrari, A, Ferreira, M, Filip, I, Fischer, F, Fitzmaurice, C, Foigt, N, Foreman, K, Frank, T, Fukumoto, T, Fullman, N, Furst, T, Furtado, J, Gakidou, E, Gall, S, Gallus, S, Ganji, M, Garcia-Basteiro, A, Gardner, W, Gebre, A, Gebremedhin, A, Gebremichael, T, Gelano, T, Geleijnse, J, Genova-Maleras, R, Geramo, Y, Gething, P, Gezae, K, Ghadami, M, Ghadiri, K, Ghasemi-Kasman, M, Ghimire, M, Ghoshal, A, Gill, P, Gill, T, Ginawi, I, Giussani, G, Gnedovskaya, E, Goldberg, E, Goli, S, Gomez-Dantes, H, Gona, P, Gopalani, S, Gorman, T, Goulart, A, Goulart, B, Grada, A, Grosso, G, Gugnani, H, Guillemin, F, Guo, Y, Gupta, P, Gupta, R, Gupta, T, Gutierrez, R, Gyawali, B, Haagsma, J, Hachinski, V, Hafezi-Nejad, N, Bidgoli, H, Hagos, T, Hailegiyorgis, T, Haj-Mirzaian, A, Hamadeh, R, Hamidi, S, Handal, A, Hankey, G, Hao, Y, Harb, H, Harikrishnan, S, Haririan, H, Haro, J, Hassankhani, H, Hassen, H, Havmoeller, R, Hay, R, Hay, S, Hedayatizadeh-Omran, A, Heibati, B, Hendrie, D, Henok, A, Heredia-Pi, I, Herteliu, C, Heydarpour, F, Heydarpour, P, Hibstu, D, Hoek, H, Hoffman, H, Hole, M, Rad, E, Hoogar, P, Hosgood, H, Hosseini, S, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hotez, P, Hoy, D, Hsairi, M, Htet, A, Huang, J, Iburg, K, Ikeda, C, Ilesanmi, O, Irvani, S, Irvine, C, Islam, S, Islami, F, Jacobsen, K, Jahangiry, L, Jahanmehr, N, Jain, S, Jakovljevic, M, James, S, Jayatilleke, A, Jeemon, P, Jha, R, Jha, V, Ji, J, Johnson, C, Jonas, J, Jonnagaddala, J, Shushtari, Z, Joshi, A, Jozwiak, J, Jungari, S, Jurisson, M, Kabir, Z, Kadel, R, Kahsay, A, Kalani, R, Kanchan, T, Kar, C, Karami, M, Karami Matin, B, Karch, A, Karema, C, Karimi, N, Karimi, S, Kasaeian, A, Kassa, D, Kassa, G, Kassa, T, Kassebaum, N, Katikireddi, S, Kaul, A, Kawakami, N, Kazemi, Z, Kazemi Karyani, A, Keighobadi, M, Keiyoro, P, Kemmer, L, Kemp, G, Kengne, A, Keren, A, Khader, Y, Khafaei, B, Khafaie, M, Khajavi, A, Khalid, N, Khalil, I, Khan, E, Khan, M, Khang, Y, Khater, M, Khazaei, M, Khoja, A, Khosravi, A, Khosravi, M, Kiadaliri, A, Kidanemariam, Z, Kiirithio, D, Kim, C, Kim, D, Kim, Y, Kimokoti, R, Kinfu, Y, Kisa, A, Kissimova-Skarbek, K, Knudsen, A, Kocarnik, J, Kochhar, S, Kokubo, Y, Kolola, T, Kopec, J, Kosen, S, Kotsakis, G, Koul, P, Koyanagi, A, Krishan, K, Krishnaswami, S, Krohn, K, Defo, B, Bicer, B, Kumar, G, Kumar, M, Kuzin, I, Lad, D, Lad, S, Lafranconi, A, Lalloo, R, Lallukka, T, Lami, F, Lang, J, Langan, S, Lansingh, V, Latifi, A, Lau, K, Lazarus, J, Leasher, J, Ledesma, J, Lee, P, Leigh, J, Leili, M, Leshargie, C, Leung, J, Levi, M, Lewycka, S, Li, S, Li, Y, Liang, X, Liao, Y, Liben, M, Lim, L, Lim, S, Limenih, M, Linn, S, Liu, S, Looker, K, Lopez, A, Lorkowski, S, Lotufo, P, Lozano, R, Lucas, T, Lunevicius, R, Lyons, R, Ma, S, Macarayan, E, Mackay, M, Maddison, E, Madotto, F, Maghavani, D, Mai, H, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malta, D, Mamun, A, Manda, A, Manguerra, H, Mansournia, M, Mantilla Herrera, A, Mantovani, L, Maravilla, J, Marcenes, W, Marks, A, Martins-Melo, F, Martopullo, I, Marz, W, Marzan, M, Massano, J, Massenburg, B, Mathur, M, Maulik, P, Mazidi, M, Mcalinden, C, Mcgrath, J, Mckee, M, Mcmahon, B, Mehata, S, Mehrotra, R, Mehta, K, Mehta, V, Mejia-Rodriguez, F, Mekonen, T, Melese, A, Melku, M, Memiah, P, Memish, Z, Mendoza, W, Mengistu, G, Mensah, G, Mereta, S, Meretoja, A, Meretoja, T, Mestrovic, T, Miazgowski, B, Miazgowski, T, Millear, A, Miller, T, Mini, G, Mirarefin, M, Mirica, A, Mirrakhimov, E, Misganaw, A, Mitchell, P, Mitiku, H, Moazen, B, Mohajer, B, Mohammad, K, Mohammadi, M, Mohammadifard, N, Mohammadnia-Afrouzi, M, Mohammed, M, Mohammed, S, Mohebi, F, Mokdad, A, Molokhia, M, Monasta, L, Montanez, J, Moosazadeh, M, Moradi, G, Moradi, M, Moradi-Lakeh, M, Moradinazar, M, Moraga, P, Morawska, L, Velasquez, I, Morgado-Da-Costa, J, Morrison, S, Moschos, M, Mousavi, S, Mruts, K, Muche, A, Muchie, K, Mueller, U, Muhammed, O, Mukhopadhyay, S, Muller, K, Mumford, J, Murthy, G, Musa, K, Mustafa, G, Nabhan, A, Nagata, C, Nagel, G, Naghavi, M, Naheed, A, Nahvijou, A, Naik, G, Najafi, F, Nam, H, Nangia, V, Nansseu, J, Neamati, N, Negoi, I, Negoi, R, Neupane, S, Newton, C, Ngunjiri, J, Nguyen, A, Nguyen, G, Nguyen, H, Nguyen, L, Nguyen, M, Nguyen, N, Nguyen, S, Nichols, E, Ningrum, D, Nixon, M, Nomura, S, Noroozi, M, Norrving, B, Noubiap, J, Nouri, H, Shiadeh, M, Nowroozi, M, Nsoesie, E, Nyasulu, P, Odell, C, Ofori-Asenso, R, Ogbo, F, Oh, I, Oladimeji, O, Olagunju, A, Olagunju, T, Olivares, P, Olsen, H, Olusanya, B, Olusanya, J, Ong, K, Ong, S, Oren, E, Ortiz, A, Ota, E, Otstavnov, S, Overland, S, Owolabi, M, Mahesh, P, Pacella, R, Pakhare, A, Pakpour, A, Pana, A, Panda-Jonas, S, Park, E, Park, J, Parry, C, Parsian, H, Pasdar, Y, Patel, S, Patil, S, Patle, A, Patton, G, Paturi, V, Paudel, D, Paulson, K, Pearce, N, Pereira, A, Pereira, D, Perico, N, Pesudovs, K, Petzold, M, Pham, H, Phillips, M, Pigott, D, Pillay, J, Piradov, M, Pirsaheb, M, Pishgar, F, Plana-Ripoll, O, Polinder, S, Popova, S, Postma, M, Pourshams, A, Poustchi, H, Prabhakaran, D, Prakash, S, Prakash, V, Prasad, N, Purcell, C, Qorbani, M, Quistberg, D, Radfar, A, Rafay, A, Rafiei, A, Rahim, F, Rahimi, K, Rahimi, Z, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Ur Rahman, M, Rahman, S, Rai, R, Rajati, F, Ranjan, P, Rao, P, Rasella, D, Rawaf, D, Rawaf, S, Reddy, K, Reiner, R, Reitsma, M, Remuzzi, G, Renzaho, A, Resnikoff, S, Rezaei, S, Rezai, M, Ribeiro, A, Roberts, N, Robinson, S, Roever, L, Ronfani, L, Roshandel, G, Rostami, A, Roth, G, Rothenbacher, D, Rubagotti, E, Sachdev, P, Sadat, N, Sadeghi, E, Saeedi Moghaddam, S, Safari, H, Safari, Y, Safari-Faramani, R, Safdarian, M, Safi, S, Safiri, S, Sagar, R, Sahebkar, A, Sahraian, M, Sajadi, H, Salam, N, Salama, J, Salamati, P, Saleem, Z, Salimi, Y, Salimzadeh, H, Salomon, J, Salvi, S, Salz, I, Samy, A, Sanabria, J, Sanchez-Nino, M, Santomauro, D, Santos, I, Santos, J, Santric Milicevic, M, Sao Jose, B, Sardana, M, Sarker, A, Sarmiento-Suarez, R, Sarrafzadegan, N, Sartorius, B, Sarvi, S, Sathian, B, Satpathy, M, Sawant, A, Sawhney, M, Saxena, S, Schaeffner, E, Schmidt, M, Schneider, I, Schutte, A, Schwebel, D, Schwendicke, F, Scott, J, Sekerija, M, Sepanlou, S, Servan-Mori, E, Seyedmousavi, S, Shabaninejad, H, Shafieesabet, A, Shahbazi, M, Shaheen, A, Shaikh, M, Shams-Beyranvand, M, Shamsi, M, Sharafi, H, Sharafi, K, Sharif, M, Sharif-Alhoseini, M, Sharma, J, Sharma, R, She, J, Sheikh, A, Shi, P, Shibuya, K, Shiferaw, M, Shigematsu, M, Shiri, R, Shirkoohi, R, Shiue, I, Shokoohinia, Y, Shokraneh, F, Shoman, H, Shrime, M, Si, S, Siabani, S, Sibai, A, Siddiqi, T, Sigfusdottir, I, Sigurvinsdottir, R, Silva, D, Silva, J, Silveira, D, Singam, N, Singh, J, Singh, N, Singh, V, Sinha, D, Skiadaresi, E, Skirbekk, V, Sliwa, K, Smith, D, Smith, M, Filho, A, Sobaih, B, Sobhani, S, Soofi, M, Sorensen, R, Soyiri, I, Sposato, L, Sreeramareddy, C, Srinivasan, V, Stanaway, J, Starodubov, V, Stein, D, Steiner, C, Steiner, T, Stokes, M, Stovner, L, Subart, M, Sudaryanto, A, Sufiyan, M, Sulo, G, Sunguya, B, Sur, P, Sykes, B, Sylaja, P, Sylte, D, Szoeke, C, Tabares-Seisdedos, R, Tabuchi, T, Tadakamadla, S, Tandon, N, Tassew, S, Tavakkoli, M, Taveira, N, Taylor, H, Tehrani-Banihashemi, A, Tekalign, T, Tekelemedhin, S, Tekle, M, Temsah, M, Temsah, O, Terkawi, A, Tessema, B, Teweldemedhin, M, Thankappan, K, Theis, A, Thirunavukkarasu, S, Thomas, N, Tilahun, B, To, Q, Tonelli, M, Topor-Madry, R, Torre, A, Tortajada-Girbes, M, Touvier, M, Tovani-Palone, M, Towbin, J, Tran, B, Tran, K, Troeger, C, Tsadik, A, Tsoi, D, Tudor Car, L, Tyrovolas, S, Ukwaja, K, Ullah, I, Undurraga, E, Updike, R, Usman, M, Uthman, O, Vaduganathan, M, Vaezi, A, Valdez, P, Varavikova, E, Varughese, S, Vasankari, T, Venketasubramanian, N, Villafaina, S, Violante, F, Vladimirov, S, Vlassov, V, Vollset, S, Vos, T, Vosoughi, K, Vujcic, I, Wagnew, F, Waheed, Y, Wang, Y, Weiderpass, E, Weintraub, R, Weiss, D, Weldegebreal, F, Weldegwergs, K, Werdecker, A, West, T, Westerman, R, Whiteford, H, Widecka, J, Wijeratne, T, Williams, H, Wilner, L, Wilson, S, Winkler, A, Wiyeh, A, Wiysonge, C, Wolfe, C, Woolf, A, Wyper, G, Xavier, D, Xu, G, Yadgir, S, Yahyazadeh Jabbari, S, Yamada, T, Yan, L, Yano, Y, Yaseri, M, Yasin, Y, Yeshaneh, A, Yimer, E, Yip, P, Yisma, E, Yonemoto, N, Yoon, S, Yotebieng, M, Younis, M, Yousefifard, M, Yu, C, Zadnik, V, Zaidi, Z, Zaman, S, Zamani, M, Zandian, H, Zar, H, Zenebe, Z, Zipkin, B, Zhou, M, Zodpey, S, Zucker, I, Zuhlke, L, Murray, C, Kyu H. H., Abate D., Abate K. H., Abay S. M., Abbafati C., Abbasi N., Abbastabar H., Abd-Allah F., Abdela J., Abdelalim A., Abdollahpour I., Abdulkader R. S., Abebe M., Abebe Z., Abil O. Z., Aboyans V., Abrham A. R., Abu-Raddad L. J., Abu-Rmeileh N. M. E., Accrombessi M. M. K., Acharya D., Acharya P., Ackerman I. N., Adamu A. A., Adebayo O. M., Adekanmbi V., Ademi Z., Adetokunboh O. O., Adib M. G., Adsuar J. C., Afanvi K. A., Afarideh M., Afshin A., Agarwal G., Agesa K. M., Aggarwal R., Aghayan S. A., Agrawal A., Ahmadi A., Ahmadi M., Ahmadieh H., Ahmed M. B., Ahmed S., Aichour A. N., Aichour I., Aichour M. T. E., Akinyemiju T., Akseer N., Al-Aly Z., Al-Eyadhy A., Al-Mekhlafi H. M., Al-Raddadi R. M., Alahdab F., Alam K., Alam T., Alashi A., Alavian S. M., Alene K. A., Alijanzadeh M., Alizadeh-Navaei R., Aljunid S. M., Alkerwi A., Alla F., Allebeck P., Alonso J., Alsharif U., Altirkawi K., Alvis-Guzman N., Aminde L. N., Amini E., Amiresmaili M., Ammar W., Amoako Y. A., Anber N. H., Andrei C. L., Androudi S., Animut M. D., Anjomshoa M., Ansha M. G., Antonio C. A. T., Anwari P., Arabloo J., Aremu O., Arnlov J., Arora A., Arora M., Artaman A., Aryal K. K., Asayesh H., Ataro Z., Ausloos M., Avila-Burgos L., Avokpaho E. F. G. A., Awasthi A., Ayala Quintanilla B. P., Ayer R., Azzopardi P. S., Babazadeh A., Badali H., Balakrishnan K., Bali A. G., Banach M., Banoub J. A. M., Barac A., Barboza M. A., Barker-Collo S. L., Barnighausen T. W., Barquera S., Barrero L. H., Bazargan-Hejazi S., Bedi N., Beghi E., Behzadifar M., Bekele B. B., Bekru E. T., Belachew A. B., Belay Y. A., Bell M. L., Bello A. K., Bennett D. A., Bensenor I. M., Berhane A., Bernabe E., Bernstein R. S., Beuran M., Beyranvand T., Bhala N., Bhatt S., Bhaumik S., Bhutta Z. A., Biadgo B., Biehl M. H., Bijani A., Bikbov B., Bilano V., Bililign N., Bin Sayeed M. S., Bisanzio D., Bjorge T., Bleyer A., Bobasa E. M., Bou-Orm I. R., Boufous S., Bourne R., Brady O. J., Brant L. C., Brayne C., Brazinova A., Breitborde N. J. K., Brenner H., Briant P. S., Briko A. N., Britton G., Brugha T., Buchbinder R., Busse R., Butt Z. A., Cahuana-Hurtado L., Campuzano Rincon J. C., Cano J., Cardenas R., Carrero J. J., Carter A., Carvalho F., Castaneda-Orjuela C. A., Rivas J. C., Castro F., Catala-Lopez F., Cercy K. M., Cerin E., Chaiah Y., Chang J. -C., Charlson F. J., Chattu V. K., Chiang P. P. -C., Chitheer A., Choi J. -Y. J., Christensen H., Christopher D. J., Chung S. -C., Cicuttini F. M., Cirillo M., Collado-Mateo D., Cooper C., Cortesi P. A., Cortinovis M., Cousin E., Criqui M. H., Cromwell E. A., Cross M., Crump J. A., Daba A. K., Dachew B. A., Dadi A. F., Dandona L., Dandona R., Dargan P. I., Daryani A., Das Gupta R., Das Neves J., Dasa T. T., Davitoiu D. V., De La Hoz F. P., De Leo D., De Neve J. -W., De Steur H., Degefa M. G., Degenhardt L., Deiparine S., Demoz G. T., Denova-Gutierrez E., Deribe K., Dervenis N., Des Jarlais D. C., Dey S., Dharmaratne S. D., Dhimal M., Dinberu M. T., Dirac M. A., Djalalinia S., Doan L., Dokova K., Doku D. T., Dorsey E. R., Doyle K. E., Driscoll T. R., Dubey M., Dubljanin E., Duken E. E., Duncan B. B., Duraes A. R., Ebrahimi H., Ebrahimpour S., Echko M. M., Edessa D., Edvardsson D., Effiong A., Eggen A. E., Ehrlich J. R., El Bcheraoui C., El-Khatib Z., Elyazar I. R. F., Enayati A., Endalifer M. L., Endries A. Y., Er B., Erskine H. E., Eskandarieh S., Esteghamati A., Esteghamati S., Fakhim H., Faramarzi M., Fareed M., Farhadi F., Farid T. A., Sa Farinha C. S. E., Farioli A., Faro A., Farzadfar F., Fazaeli A. A., Feigin V. L., Fentahun N., Fereshtehnejad S. -M., Fernandes E., Fernandes J. C., Ferrari A. J., Ferreira M. L., Filip I., Fischer F., Fitzmaurice C., Foigt N. A., Foreman K. J., Frank T. D., Fukumoto T., Fullman N., Furst T., Furtado J. M., Gakidou E., Gall S., Gallus S., Ganji M., Garcia-Basteiro A. L., Gardner W. M., Gebre A. K., Gebremedhin A. T., Gebremichael T. G., Gelano T. F., Geleijnse J. M., Genova-Maleras R., Geramo Y. C. D., Gething P. W., Gezae K. E., Ghadami M. R., Ghadiri K., Ghasemi-Kasman M., Ghimire M., Ghoshal A. G., Gill P. S., Gill T. K., Ginawi I. A., Giussani G., Gnedovskaya E. V., Goldberg E. M., Goli S., Gomez-Dantes H., Gona P. N., Gopalani S. V., Gorman T. M., Goulart A. C., Goulart B. N. G., Grada A., Grosso G., Gugnani H. C., Guillemin F., Guo Y., Gupta P. C., Gupta R., Gupta T., Gutierrez R. A., Gyawali B., Haagsma J. A., Hachinski V., Hafezi-Nejad N., Bidgoli H. H., Hagos T. B., Hailegiyorgis T. T., Haj-Mirzaian A., Hamadeh R. R., Hamidi S., Handal A. J., Hankey G. J., Hao Y., Harb H. L., Harikrishnan S., Haririan H., Haro J. M., Hassankhani H., Hassen H. Y., Havmoeller R., Hay R. J., Hay S. I., Hedayatizadeh-Omran A., Heibati B., Hendrie D., Henok A., Heredia-Pi I., Herteliu C., Heydarpour F., Heydarpour P., Hibstu D. T., Hoek H. W., Hoffman H. J., Hole M. K., Rad E. H., Hoogar P., Hosgood H. D., Hosseini S. M., Hosseinzadeh M., Hostiuc M., Hostiuc S., Hotez P. J., Hoy D. 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A., Pacella R., Pakhare A. P., Pakpour A. H., Pana A., Panda-Jonas S., Park E. -K., Park J., Parry C. D. H., Parsian H., Pasdar Y., Patel S., Patil S. T., Patle A., Patton G. C., Paturi V. R., Paudel D., Paulson K. R., Pearce N., Pereira A., Pereira D. M., Perico N., Pesudovs K., Petzold M., Pham H. Q., Phillips M. R., Pigott D. M., Pillay J. D., Piradov M. A., Pirsaheb M., Pishgar F., Plana-Ripoll O., Polinder S., Popova S., Postma M. J., Pourshams A., Poustchi H., Prabhakaran D., Prakash S., Prakash V., Prasad N., Purcell C. A., Qorbani M., Quistberg D. A., Radfar A., Rafay A., Rafiei A., Rahim F., Rahimi K., Rahimi Z., Rahimi-Movaghar A., Rahimi-Movaghar V., Rahman M., Ur Rahman M. H., Rahman M. A., Rahman S. U., Rai R. K., Rajati F., Ranjan P., Rao P. C., Rasella D., Rawaf D. L., Rawaf S., Reddy K. S., Reiner R. C., Reitsma M. B., Remuzzi G., Renzaho A. M. N., Resnikoff S., Rezaei S., Rezai M. S., Ribeiro A. L. P., Roberts N. L. S., Robinson S. R., Roever L., Ronfani L., Roshandel G., Rostami A., Roth G. A., Rothenbacher D., Rubagotti E., Sachdev P. S., Sadat N., Sadeghi E., Saeedi Moghaddam S., Safari H., Safari Y., Safari-Faramani R., Safdarian M., Safi S., Safiri S., Sagar R., Sahebkar A., Sahraian M. A., Sajadi H. S., Salam N., Salama J. S., Salamati P., Saleem Z., Salimi Y., Salimzadeh H., Salomon J. A., Salvi S. S., Salz I., Samy A. M., Sanabria J., Sanchez-Nino M. D., Santomauro D. F., Santos I. S., Santos J. V., Santric Milicevic M. M., Sao Jose B. P., Sardana M., Sarker A. R., Sarmiento-Suarez R., Sarrafzadegan N., Sartorius B., Sarvi S., Sathian B., Satpathy M., Sawant A. R., Sawhney M., Saxena S., Schaeffner E., Schmidt M. I., Schneider I. J. C., Schutte A. E., Schwebel D. C., Schwendicke F., Scott J. G., Sekerija M., Sepanlou S. G., Servan-Mori E., Seyedmousavi S., Shabaninejad H., Shafieesabet A., Shahbazi M., Shaheen A. A., Shaikh M. A., Shams-Beyranvand M., Shamsi M., Sharafi H., Sharafi K., Sharif M., Sharif-Alhoseini M., Sharma J., Sharma R., She J., Sheikh A., Shi P., Shibuya K., Shiferaw M. S., Shigematsu M., Shiri R., Shirkoohi R., Shiue I., Shokoohinia Y., Shokraneh F., Shoman H., Shrime M. G., Si S., Siabani S., Sibai A. M., Siddiqi T. J., Sigfusdottir I. D., Sigurvinsdottir R., Silva D. A. S., Silva J. P., Silveira D. G. A., Singam N. S. V., Singh J. A., Singh N. P., Singh V., Sinha D. N., Skiadaresi E., Skirbekk V., Sliwa K., Smith D. L., Smith M., Filho A. M. S., Sobaih B. H., Sobhani S., Soofi M., Sorensen R. J. D., Soyiri I. N., Sposato L. A., Sreeramareddy C. T., Srinivasan V., Stanaway J. D., Starodubov V. I., Stein D. J., Steiner C., Steiner T. J., Stokes M. A., Stovner L. J., Subart M. L., Sudaryanto A., Sufiyan M. B., Sulo G., Sunguya B. F., Sur P. J., Sykes B. L., Sylaja P. N., Sylte D. O., Szoeke C. E. I., Tabares-Seisdedos R., Tabuchi T., Tadakamadla S. K., Tandon N., Tassew S. 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C., Wilner L. B., Wilson S., Winkler A. S., Wiyeh A. B., Wiysonge C. S., Wolfe C. D. A., Woolf A. D., Wyper G. M. A., Xavier D., Xu G., Yadgir S., Yahyazadeh Jabbari S. H., Yamada T., Yan L. L., Yano Y., Yaseri M., Yasin Y. J., Yeshaneh A., Yimer E. M., Yip P., Yisma E., Yonemoto N., Yoon S. -J., Yotebieng M., Younis M. Z., Yousefifard M., Yu C., Zadnik V., Zaidi Z., Zaman S. B., Zamani M., Zandian H., Zar H. J., Zenebe Z. M., Zipkin B., Zhou M., Zodpey S., Zucker I., Zuhlke L. J., and Murray C. J. L.
- Abstract
Background: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted lifeyears (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severityof ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-speci?c mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Sociodemographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7·4 years (95% uncertainty interval 7·1-7·8), from 65·6 years (65·3-65·8) in 1990 to 73·0 years (72·7-73·3) in 2017. The increase in years of life varied from 5·1 years (5·0-5·3) in high SDI countries to 12·0 years (11·3-12·8) in low SDI countries. Of the additional years of life expected at birth, 26·3% (20·1-33·1) were expected to be spent in poor health in high SDI countries compared with 11·7% (8·8-15·1) in low-middle SDI countries. HALE at birth increased
- Published
- 2018
4. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
- Author
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Male ,Health Status ,health statu ,HALE ,mortality rate ,communicable disease ,DALYs ,Global Burden of Disease ,Risk Factors ,Prevalence ,Medicine and Health Sciences ,Singapore ,OUTCOMES ,disability-adjusted life year ,international cooperation ,Medicine (all) ,11 Medical And Health Sciences ,Central African Republic ,newborn disease ,IRON-DEFICIENCY ,AIDS ,priority journal ,Bahrain ,disease severity ,Female ,Quality-Adjusted Life Years ,cerebrovascular accident ,Ukraine ,Life Sciences & Biomedicine ,INTERVENTIONS ,Slovakia ,DISORDERS ,Burundi ,WEIGHTS ,GBD 2017 DALYs and HALE Collaborators ,Communicable Diseases ,Article ,STYLE ,Medicine, General & Internal ,Life Expectancy ,General & Internal Medicine ,Humans ,Disabled Persons ,human ,Healthy Lifestyle ,HALE, DALYs, global burden of disease ,Mortality ,Aged ,Science & Technology ,Mortality, Premature ,HIV ,ischemic heart disease ,major clinical study ,PREVENTION ,non communicable disease ,GBD, disability-adjusted life-years ,age ,sex factor ,Socioeconomic Factors ,Algeria ,Federation of Bosnia and Herzegovina ,lower respiratory tract infection ,Wounds and Injuries ,GENDER ,Human medicine ,trend study ,chronic obstructive lung disease - Abstract
Background How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-specific mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Sociodemographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7.4 years (95% uncertainty interval 74-7.8), from 65.6 years (65.3-65- 8) in 1990 to 73.0 years (72.7-73.3) in 2017. The increase in years of life varied from 5.1 years (5.0-5.3) in high SDI countries to 12.0 years (11.3-12.8) in low SDI countries. Of the additional years of life expected at birth, 26.3% (20.1-33.1) were expected to be spent in poor health in high SDI countries compared with 11.7% (8.8-15.1) in low-middle SDI countries. HALE at birth increased by 6.3 years (5.9-6.7), from 57.0 years (54.6-59.1) in 1990 to 63.3 years (60.5-65.7) in 2017. The increase varied from 3.8 years (3.4-4.1) in high SDI countries to 10.5 years (9.8-11.2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1.0 year (0.4-1.7) in Saint Vincent and the Grenadines (62.4 years [59.9-64.7] in 1990 to 63.5 years [60.9-65.8] in 2017) to 23.7 years (21.9-25.6) in Eritrea (30.7 years [28.9-32.2] in 1990 to 54.4 years [51.5-57.1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1.4 years (0.6-2.3) in Algeria to 11.9 years (10.9-12.9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75.8 years [72.4-78.7]) and males (72.6 years [69 " 8-75.0]) and the lowest estimates were in Central African Republic (47.0 years [43.7-50.2] for females and 42.8 years [40.1-45.6] for males). Globally, in 2017, the five leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41.3% (38.8-43.5) for communicable diseases and by 49"8% (47.9-51.6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40.1% (36.8-43.0), although age-standardised DALY rates decreased by 18.1% (16.0-20.2). Interpretation With increasing life expectancy in most countries, the question of whether the additional years of life gained are spent in good health or poor health has been increasingly relevant because of the potential policy implications, such as health-care provisions and extending retirement ages. In some locations, a large proportion of those additional years are spent in poor health. Large inequalities in HALE and disease burden exist across countries in different SDI quintiles and between sexes. The burden of disabling conditions has serious implications for health system planning and health-related expenditures. Despite the progress made in reducing the burden of communicable diseases and neonatal disorders in low S DI countries, the speed of this progress could be increased by scaling up proven interventions. The global trends among non-communicable diseases indicate that more effort is needed to maximise HALE, such as risk prevention and attention to upstream determinants of health. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.
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5. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
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Gill, T.K. Ginawi, I.A. Giussani, G. Gnedovskaya, E.V. Goldberg, E.M. Goli, S. Gómez-Dantés, H. Gona, P.N. Gopalani, S.V. Gorman, T.M. Goulart, A.C. Goulart, B.N.G. Grada, A. Grosso, G. Gugnani, H.C. Guillemin, F. Guo, Y. Gupta, P.C. Gupta, R. Gupta, R. Gupta, T. Gutiérrez, R.A. Gyawali, B. Haagsma, J.A. Hachinski, V. Hafezi-Nejad, N. Bidgoli, H.H. Hagos, T.B. Hailegiyorgis, T.T. Haj-Mirzaian, A. Haj-Mirzaian, A. Hamadeh, R.R. Hamidi, S. Handal, A.J. Hankey, G.J. Hao, Y. Harb, H.L. Harikrishnan, S. Haririan, H. Haro, J.M. Hassankhani, H. Hassen, H.Y. Havmoeller, R. Hay, R.J. Hay, S.I. Hedayatizadeh-Omran, A. Heibati, B. Hendrie, D. Henok, A. Heredia-Pi, I. Herteliu, C. Heydarpour, F. Heydarpour, P. Hibstu, D.T. Hoek, H.W. Hoffman, H.J. Hole, M.K. Rad, E.H. Hoogar, P. Hosgood, H.D. Hosseini, S.M. Hosseinzadeh, M. Hostiuc, M. Hostiuc, S. Hotez, P.J. Hoy, D.G. Hsairi, M. Htet, A.S. Huang, J.J. Iburg, K.M. Ikeda, C.T. Ilesanmi, O.S. Irvani, S.S.N. Irvine, C.M.S. Islam, S.M.S. Islami, F. Jacobsen, K.H. Jahangiry, L. Jahanmehr, N. Jain, S.K. Jakovljevic, M. James, S.L. Jayatilleke, A.U. Jeemon, P. Jha, R.P. Jha, V. Ji, J.S. Johnson, C.O. Jonas, J.B. Jonnagaddala, J. Shushtari, Z.J. Joshi, A. Jozwiak, J.J. Jungari, S.B. Jürisson, M. Kabir, Z. Kadel, R. Kahsay, A. Kalani, R. Kanchan, T. Kar, C. Karami, M. Karami Matin, B. Karch, A. Karema, C. Karimi, N. Karimi, S.M. Kasaeian, A. Kassa, D.H. Kassa, G.M. Kassa, T.D. Kassebaum, N.J. Katikireddi, S.V. Kaul, A. Kawakami, N. Kazemi, Z. Kazemi Karyani, A. Keighobadi, M.M. Keiyoro, P.N. Kemmer, L. Kemp, G.R. Kengne, A.P. Keren, A. Khader, Y.S. Khafaei, B. Khafaie, M.A. Khajavi, A. Khalid, N. Khalil, I.A. Khan, E.A. Khan, M.S. Khan, M.A. Khang, Y.-H. Khater, M.M. Khazaei, M. Khoja, A.T. Khosravi, A. Khosravi, M.H. Kiadaliri, A.A. Kidanemariam, Z.T. Kiirithio, D.N. Kim, C.-I. Kim, D. Kim, Y.-E. Kim, Y.J. Kimokoti, R.W. Kinfu, Y. Kisa, A. Kissimova-Skarbek, K. Knudsen, A.K.S. Kocarnik, J.M. Kochhar, S. Kokubo, Y. Kolola, T. Kopec, J.A. Kosen, S. Kotsakis, G.A. Koul, P.A. Koyanagi, A. Krishan, K. Krishnaswami, S. Krohn, K.J. Defo, B.K. Bicer, B.K. Kumar, G.A. Kumar, M. Kuzin, I. Lad, D.P. Lad, S.D. Lafranconi, A. Lalloo, R. Lallukka, T. Lami, F.H. Lang, J.J. Langan, S.M. Lansingh, V.C. Latifi, A. Lau, K.M.-M. Lazarus, J.V. Leasher, J.L. Ledesma, J.R. Lee, P.H. Leigh, J. Leili, M. Leshargie, C.T. Leung, J. Levi, M. Lewycka, S. Li, S. Li, Y. Liang, X. Liao, Y. Liben, M.L. Lim, L.-L. Lim, S.S. Limenih, M.A. Linn, S. Liu, S. Looker, K.J. Lopez, A.D. Lorkowski, S. Lotufo, P.A. Lozano, R. Lucas, T.C.D. Lunevicius, R. Lyons, R.A. Ma, S. Macarayan, E.R.K. Mackay, M.T. Maddison, E.R. Madotto, F. Maghavani, D.P. Mai, H.T. Majdan, M. Majdzadeh, R. Majeed, A. Malekzadeh, R. Malta, D.C. Mamun, A.A. Manda, A.-L. Manguerra, H. Mansournia, M.A. Mantilla Herrera, A.M. Mantovani, L.G. Maravilla, J.C. Marcenes, W. Marks, A. Martins-Melo, F.R. Martopullo, I. März, W. Marzan, M.B. Massano, J. Massenburg, B.B. Mathur, M.R. Maulik, P.K. Mazidi, M. McAlinden, C. McGrath, J.J. McKee, M. McMahon, B.J. Mehata, S. Mehrotra, R. Mehta, K.M. Mehta, V. Mejia-Rodriguez, F. Mekonen, T. Melese, A. Melku, M. Memiah, P.T.N. Memish, Z.A. Mendoza, W. Mengistu, G. Mensah, G.A. Mereta, S.T. Meretoja, A. Meretoja, T.J. Mestrovic, T. Miazgowski, B. Miazgowski, T. Millear, A.I. Miller, T.R. Mini, G.K. Mirarefin, M. Mirica, A. Mirrakhimov, E.M. Misganaw, A.T. Mitchell, P.B. Mitiku, H. Moazen, B. Mohajer, B. Mohammad, K.A. Mohammadi, M. Mohammadifard, N. Mohammadnia-Afrouzi, M. Mohammed, M.A. Mohammed, S. Mohebi, F. Mokdad, A.H. Molokhia, M. Monasta, L. Montanez, J.C. Moosazadeh, M. Moradi, G. Moradi, M. Moradi-Lakeh, M. Moradinazar, M. Moraga, P. Morawska, L. Velásquez, I.M. Morgado-Da-Costa, J. Morrison, S.D. Moschos, M.M. Mousavi, S.M. Mruts, K.B. Muche, A.A. Muchie, K.F. Mueller, U.O. Muhammed, O.S. Mukhopadhyay, S. Muller, K. Mumford, J.E. Murthy, G.V.S. Musa, K.I. Mustafa, G. Nabhan, A.F. Nagata, C. Nagel, G. Naghavi, M. Naheed, A. Nahvijou, A. Naik, G. Najafi, F. Nam, H.S. Nangia, V. Nansseu, J.R. Neamati, N. Negoi, I. Negoi, R.I. Neupane, S. Newton, C.R.J. Ngunjiri, J.W. Nguyen, A.Q. Nguyen, G. Nguyen, H.T. Nguyen, H.L.T. Nguyen, H.T. Nguyen, L.H. Nguyen, M. Nguyen, N.B. Nguyen, S.H. Nichols, E. Ningrum, D.N.A. Nixon, M.R. Nomura, S. Noroozi, M. Norrving, B. Noubiap, J.J. Nouri, H.R. Shiadeh, M.N. Nowroozi, M.R. Nsoesie, E.O. Nyasulu, P.S. Odell, C.M. Ofori-Asenso, R. Ogbo, F.A. Oh, I.-H. Oladimeji, O. Olagunju, A.T. Olagunju, T.O. Olivares, P.R. Olsen, H.E. Olusanya, B.O. Olusanya, J.O. Ong, K.L. Ong, S.K. Oren, E. Ortiz, A. Ota, E. Otstavnov, S.S. Overland, S. Owolabi, M.O. Mahesh, P.A. Pacella, R. Pakhare, A.P. Pakpour, A.H. Pana, A. Panda-Jonas, S. Park, E.-K. Park, J. Parry, C.D.H. Parsian, H. Pasdar, Y. Patel, S. Patil, S.T. Patle, A. Patton, G.C. Paturi, V.R. Paudel, D. Paulson, K.R. Pearce, N. Pereira, A. Pereira, D.M. Perico, N. Pesudovs, K. Petzold, M. Pham, H.Q. Phillips, M.R. Pigott, D.M. Pillay, J.D. Piradov, M.A. Pirsaheb, M. Pishgar, F. Plana-Ripoll, O. Polinder, S. Popova, S. Postma, M.J. Pourshams, A. Poustchi, H. Prabhakaran, D. Prakash, S. Prakash, V. Prasad, N. Purcell, C.A. Qorbani, M. Quistberg, D.A. Radfar, A. Rafay, A. Rafiei, A. Rahim, F. Rahimi, K. Rahimi, Z. Rahimi-Movaghar, A. Rahimi-Movaghar, V. Rahman, M. Ur Rahman, M.H. Rahman, M.A. Rahman, S.U. Rai, R.K. Rajati, F. Ranjan, P. Rao, P.C. Rasella, D. Rawaf, D.L. Rawaf, S. Reddy, K.S. Reiner, R.C. Reitsma, M.B. Remuzzi, G. Renzaho, A.M.N. Resnikoff, S. Rezaei, S. Rezai, M.S. Ribeiro, A.L.P. Roberts, N.L.S. Robinson, S.R. Roever, L. Ronfani, L. Roshandel, G. Rostami, A. Roth, G.A. Rothenbacher, D. Rubagotti, E. Sachdev, P.S. Sadat, N. Sadeghi, E. Saeedi Moghaddam, S. Safari, H. Safari, Y. Safari-Faramani, R. Safdarian, M. Safi, S. Safiri, S. Sagar, R. Sahebkar, A. Sahraian, M.A. Sajadi, H.S. Salam, N. Salama, J.S. Salamati, P. Saleem, Z. Salimi, Y. Salimzadeh, H. Salomon, J.A. Salvi, S.S. Salz, I. Samy, A.M. Sanabria, J. Sanchez-Nino, M.D. Santomauro, D.F. Santos, I.S. Santos, J.V. Santric Milicevic, M.M. Sao Jose, B.P. Sardana, M. Sarker, A.R. Sarmiento-Suárez, R. Sarrafzadegan, N. Sartorius, B. Sarvi, S. Sathian, B. Satpathy, M. Sawant, A.R. Sawhney, M. Saxena, S. Schaeffner, E. Schmidt, M.I. Schneider, I.J.C. Schutte, A.E. Schwebel, D.C. Schwendicke, F. Scott, J.G. Sekerija, M. Sepanlou, S.G. Serván-Mori, E. Seyedmousavi, S. Shabaninejad, H. Shafieesabet, A. Shahbazi, M. Shaheen, A.A. Shaikh, M.A. Shams-Beyranvand, M. Shamsi, M. Sharafi, H. Sharafi, K. Sharif, M. Sharif-Alhoseini, M. Sharma, J. Sharma, R. She, J. Sheikh, A. Shi, P. Shibuya, K. Shiferaw, M.S. Shigematsu, M. Shiri, R. Shirkoohi, R. Shiue, I. Shokoohinia, Y. Shokraneh, F. Shoman, H. Shrime, M.G. Si, S. Siabani, S. Sibai, A.M. Siddiqi, T.J. Sigfusdottir, I.D. Sigurvinsdottir, R. Silva, D.A.S. Silva, J.P. Silveira, D.G.A. Singam, N.S.V. Singh, J.A. Singh, N.P. Singh, V. Sinha, D.N. Skiadaresi, E. Skirbekk, V. Sliwa, K. Smith, D.L. Smith, M. Filho, A.M.S. Sobaih, B.H. Sobhani, S. Soofi, M. Sorensen, R.J.D. Soyiri, I.N. Sposato, L.A. Sreeramareddy, C.T. Srinivasan, V. Stanaway, J.D. Starodubov, V.I. Stein, D.J. Steiner, C. Steiner, T.J. Stokes, M.A. Stovner, L.J. Subart, M.L. Sudaryanto, A. Sufiyan, M.B. Sulo, G. Sunguya, B.F. Sur, P.J. Sykes, B.L. Sylaja, P.N. Sylte, D.O. Szoeke, C.E.I. Tabarés-Seisdedos, R. Tabuchi, T. Tadakamadla, S.K. Tandon, N. Tassew, S.G. Tavakkoli, M. Taveira, N. Taylor, H.R. Tehrani-Banihashemi, A. Tekalign, T.G. Tekelemedhin, S.W. Tekle, M.G. Temsah, M.-H. Temsah, O. Terkawi, A.S. Tessema, B. Teweldemedhin, M. Thankappan, K.R. Theis, A. Thirunavukkarasu, S. Thomas, N. Tilahun, B. To, Q.G. Tonelli, M. Topor-Madry, R. Torre, A.E. Tortajada-Girbés, M. Touvier, M. Tovani-Palone, M.R. Towbin, J.A. Tran, B.X. Tran, K.B. Troeger, C.E. Tsadik, A.G. Tsoi, D. Tudor Car, L. Tyrovolas, S. Ukwaja, K.N. Ullah, I. Undurraga, E.A. Updike, R.L. Usman, M.S. Uthman, O.A. Vaduganathan, M. Vaezi, A. Valdez, P.R. Varavikova, E. Varughese, S. Vasankari, T.J. Venketasubramanian, N. Villafaina, S. Violante, F.S. Vladimirov, S.K. Vlassov, V. Vollset, S.E. Vos, T. Vosoughi, K. Vujcic, I.S. Wagnew, F.S. Waheed, Y. Wang, Y. Wang, Y.-P. Weiderpass, E. Weintraub, R.G. Weiss, D.J. Weldegebreal, F. Weldegwergs, K.G. Werdecker, A. West, T.E. Westerman, R. Whiteford, H.A. Widecka, J. Wijeratne, T. Williams, H.C. Wilner, L.B. Wilson, S. Winkler, A.S. Wiyeh, A.B. Wiysonge, C.S. Wolfe, C.D.A. Woolf, A.D. Wyper, G.M.A. Xavier, D. Xu, G. Yadgir, S. Yahyazadeh Jabbari, S.H. Yamada, T. Yan, L.L. Yano, Y. Yaseri, M. Yasin, Y.J. Yeshaneh, A. Yimer, E.M. Yip, P. Yisma, E. Yonemoto, N. Yoon, S.-J. Yotebieng, M. Younis, M.Z. Yousefifard, M. Yu, C. Zadnik, V. Zaidi, Z. Zaman, S.B. Zamani, M. Zandian, H. Zar, H.J. Zenebe, Z.M. Zipkin, B. Zhou, M. Zodpey, S. Zucker, I. Zuhlke, L.J. Murray, C.J.L. GBD 2017 DALYs HALE Collaborators
- Abstract
Background: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted lifeyears (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severityof ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-speci?c mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Sociodemographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7·4 years (95% uncertainty interval 7·1-7·8), from 65·6 years (65·3-65·8) in 1990 to 73·0 years (72·7-73·3) in 2017. The increase in years of life varied from 5·1 years (5·0-5·3) in high SDI countries to 12·0 years (11·3-12·8) in low SDI countries. Of the additional years of life expected at birth, 26·3% (20·1-33·1) were expected to be spent in poor health in high SDI countries compared with 11·7% (8·8-15·1) in low-middle SDI countries. HALE at birth increased by 6·3 years (5·9-6·7), from 57·0 years (54·6-59·1) in 1990 to 63·3 years (60·5-65·7) in 2017. The increase varied from 3·8 years (3·4-4·1) in high SDI countries to 10·5 years (9·8-11·2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1·0 year (0·4-1·7) in Saint Vincent and the Grenadines (62·4 years [59·9-64·7] in 1990 to 63·5 years [60·9-65·8] in 2017) to 23·7 years (21·9-25·6) in Eritrea (30·7 years [28·9-32·2] in 1990 to 54·4 years [51·5-57·1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1·4 years (0·6-2·3) in Algeria to 11·9 years (10·9-12·9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75·8 years [72·4-78·7]) and males (72·6 years [69·8-75·0]) and the lowest estimates were in Central African Republic (47·0 years [43·7-50·2] for females and 42·8 years [40·1-45·6] for males). Globally, in 2017, the ?ve leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41·3% (38·8-43·5) for communicable diseases and by 49·8% (47·9-51·6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40·1% (36·8-43·0), although age-standardised DALY rates decreased by 18·1% (16·0-20·2). Interpretation With increasing life expectancy in most countries, the question of whether the additional years of life gained are spent in good health or poor health has been increasingly relevant because of the potential policy implications, such as health-care provisions and extending retirement ages. In some locations, a large proportion of those additional years are spent in poor health. Large inequalities in HALE and disease burden exist across countries in different SDI quintiles and between sexes. The burden of disabling conditions has serious implications for health system planning and health-related expenditures. Despite the progress made in reducing the burden of communicable diseases and neonatal disorders in low SDI countries, the speed of this progress could be increased by scaling up proven interventions. The global trends among non-communicable diseases indicate that more effort is needed to maximise HALE, such as risk prevention and attention to upstream determinants of health. Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
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- 2018
6. Some like it pungent and vile. TRPA1 as a molecular target for the malodorous vinyl disulfides from asafoetida
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Shokoohinia Y a, b, Chianese G c, Appendino G d, Di Marzo V e, De Petrocellis L f, Ghannad A g, Taghvayi R g, Fattahian K g, Soltani R h, and Taglialatela-Scafati O c
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Asafoetida ,Cysteamine assay ,food and beverages ,Disulfides ,TRPA1 activation - Abstract
Ferula assa-foetida L. is a major source of asafoetida, a foul-smelling gum-resin of dietary and medicinal relevance. Investigation of the roots and latex of F. assa-foetida afforded various mixed vinyl disulfides, including two novel asadisulfide-type esters (3c and 3d). The reactivity of asadisulfide (3b) was investigated in the cysteamine NMR assay, where it behaved as disulfide shuffling agents due to the high mobility of the vinyl sulfide moiety. In accordance with their transthiolation capacity, these compounds potently activated TRPA1, the target of mustard oil and the pungent sulfur compounds from onion and garlic, qualifying S-alkyl-S-alkenyldisulfides, a rare class of natural products, as a novel class of dietary TRPA1 activators. These observations provide a mechanistic basis for rationalizing some of the sensory properties and potential beneficial health claims associated to the use of asafoetida as a spice and as a medicine.
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- 2013
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7. Pre-myrsinanes and deoxygenated phorboids from the Iranian spurge Euphorbia macroclada Boiss.
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Shokoohinia, Y, primary, Taglialatela-Scafati, O, additional, Sajjadi, S, additional, Zolfaghari, B, additional, and Appendino, G, additional
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- 2010
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8. New jatrophanes from Euphorbia bungei Boiss.
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Shokoohinia, Y, primary, Taglialatela-Scafati, O, additional, Sajjadi, S, additional, Zolfaghari, B, additional, and Appendino, G, additional
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- 2010
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9. Isolation of 3-butyliden-4,5-dihydrophthalide and steroids from Kelussia odoratissima, a Persian food seasoning
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Shokoohinia, Y, primary, Sajjadi, S, additional, and MehrAmiri, P, additional
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- 2010
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10. Isolation and biological evaluation of a triterpenoid from fruits of wild caraway (Bunium persicum Boiss.)
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Shokoohinia, Y, primary, Taglialatela-Scafati, O, additional, Munoz, E, additional, Sajjadi, S, additional, and Appendino, G, additional
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- 2010
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11. Antispasmodic effects of Prangos ferulacea acetone extract and its main component osthole on ileum contraction
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Hassan Sadraei, Shokoohinia, Y., Sajjadi, S. E., and Mozafari, M.
12. Chemical composition of essential oil of Prangos ferulacea (L.) Lindl. roots
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Seyed Ebrahim Sajjadi, Shokoohinia, Y., and Gholamzadeh, S.
13. Chemical composition of essential oil of Ferulago macrocarpa (Fenzl) Boiss. Fruits
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Seyed Ebrahim Sajjadi, Shokoohinia, Y., and Jamali, M.
14. Antispasmodic effect of osthole and prangos ferulacea extract on rat uterus smooth muscle motility
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Sadraei, H., Shokoohinia, Y., Seyed Ebrahim Sajjadi, and Ghadirian, B.
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Prangos ferulacea ,Osthole ,Original Article ,Ach ,Oxytocin ,EFS ,KCl - Abstract
Several species of Prangos are traditionally used as emollient, carminative, tonic, anti-flatulent, anthelmintic and anti-thrombotic agents. Osthole, a coumarin isolated from Prangos, are believed to be responsible for some of its effects. In this research, relaxant effects of Prangos ferulacea extract and osthole on rat uterus contraction induced by KCl, acetylcholine (ACh), oxytocin and electrical field stimulation (EFS) was investigated and compared with atropine and salbutamol. P. ferulacea acetonic extract concentration-dependently relaxed uterine contraction induced by KCl (IC(50)=13 ± 0.81 μg/ml), ACh (IC(50)=12 ± 1.38 μg/ml), oxytocin (IC(50)=16 ± 3.14 μg/ml) and EFS (IC(50)=11 ± 1.5 μg/ml). However, the extract at lower concentration (2.5 μg/ml) potentiated the EFS response. Osthole only had inhibitory effect on rat uterus and its relaxant effect was observed at lower concentration in comparison with P. ferulacea extract. Osthole in a similar way inhibited the response to KCl (IC(50)=4 ± 0.13 μg/ml), ACh (IC(50)=4 ± 0.8 μg/ml), oxytocin (IC(50)=4 ± 0.8 μg/ml) and EFS (IC(50)=1.5 ± 0.5 μg/ml). Our results demonstrated that osthole acted directly on uterus smooth muscle to induce relaxation, whereas P. ferulacea caused both contraction and relaxation of rat uterine smooth muscle. The relaxation of osthole might be mediated through Ca(2+) channel blocking activity as it inhibited the response to KCl. Mechanisms other than Ca(2+) channel blocking appeared to be responsible for ACh relaxation effect of osthole.
15. Nutraceuticals for parkinson's disease
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Chauhdary, Z., Shah, M. A., Saleem, U., Rasul, A., Khan, A., Al-Harrasi, A., Blundell, R., Della Parambi, Alharbi, K. S., and Shokoohinia, Y.
16. Salvigenin, a trimethoxylated flavone from achillea wilhelmsii c. Koch, exerts combined lipid-lowering and mitochondrial stimulatory effects
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Zahra Farhangi, Fereshteh Jalilian, Daniela Rigano, Carmina Sirignano, Mariano Stornaiuolo, Mahdi Mojarrab, Orazio Taglialatela-Scafati, Azam Chahardoli, Yalda Shokoohinia, Nadia Badolati, Elena Serino, Serino, E., Chahardoli, A., Badolati, N., Sirignano, C., Jalilian, F., Mojarrab, M., Farhangi, Z., Rigano, D., Stornaiuolo, M., Shokoohinia, Y., and Taglialatela-Scafati, O.
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phytochemical analysis ,Physiology ,Glucose uptake ,Clinical Biochemistry ,Isovitexin ,Vitexin ,RM1-950 ,Sesquiterpene ,01 natural sciences ,Biochemistry ,Palmitic acid ,chemistry.chemical_compound ,Biosynthesis ,Molecular Biology ,010405 organic chemistry ,Achillea wilhelmsii ,Glucose transporter ,Sesquiterpenoids ,Cell Biology ,Metabolic syndrome ,0104 chemical sciences ,Phytochemical analysi ,010404 medicinal & biomolecular chemistry ,Phytochemical ,chemistry ,Mitochondrial stimulatory activity ,Therapeutics. Pharmacology - Abstract
Phytochemical analysis of the Iranian plant Achillea wilhelmsii led to the isolation of 17 pure secondary metabolites belonging to the classes of sesquiterpenoids and phenolics. Two of these compounds, named wilhemsin (7) and wilhelmsolide (9), are new sesquiterpenoids, and the first shows undescribed structural features. Their structures were elucidated through extensive spectroscopic analysis, mainly based on 1D and 2D NMR, and chemical derivatization. Starting from plant traditional use and previous reports on the activity of the plant extracts, all the pure compounds were evaluated on endpoints related to the treatment of metabolic syndrome. The sesquiterpene hanphyllin (8) showed a selective cholesterol-lowering activity (−12.7% at 30 µM), santoflavone (13) stimulated glucose uptake via the GLUT transporter (+16.2% at 30 µM), while the trimethoxylated flavone salvigenin (14) showed a dual activity in decreasing lipid levels (−22.5% palmitic acid biosynthesis at 30 µM) and stimulating mitochondrial functionality (+15.4% at 30 µM). This study further confirms that, in addition to the antioxidants vitexin, isovitexin, and isoschaftoside, A. wilhelmsii extracts contain molecules that can act at different levels on the metabolic syndrome symptoms.
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- 2021
17. Effects of Echinacea purpurea and Alkylamides on Respiratory Virus Replication and IL-8 Expression In Vitro.
- Author
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Puchalski K, Gerstel JA, Jimoh A, Shokoohinia Y, and Langland J
- Subjects
- Humans, Amides pharmacology, Amides chemistry, Rhinovirus drug effects, Animals, Dogs, Echinacea chemistry, Interleukin-8 metabolism, Virus Replication drug effects, Plant Extracts pharmacology, Plant Extracts chemistry, Antiviral Agents pharmacology, Antiviral Agents chemistry
- Abstract
Echinacea purpurea is a perennial medicinal herb with important immunomodulatory and anti-inflammatory properties, especially purported for the alleviation of cold and flu symptoms. Different classes of secondary metabolites of the plant, such as alkylamides, caffeic acid derivatives, polysaccharides, flavonoids, and glycoproteins, are believed to be biologically and pharmacologically active. Although previous research suggests that the alkylamides present in Echinacea may be responsible for reducing the symptoms associated with the common cold or flu through their immunomodulatory activity, the roles of specific alkylamides and their targets (i.e., immune and/or antiviral) have not been well-elucidated or established. This study tested the antiviral and cytokine regulatory activity of various specific alkylamides that are present predominantly in Echinacea root extracts and found that one specific alkylamide, Dodeca-2 E ,4 E -Dienoic acid isobutylamide, had potent antiviral activity against rhinovirus (the causative agent of most common colds) and influenza virus, as well as potent inhibition of IL-8 cytokine production. IL-8 is responsible for many of the symptoms associated with the common cold and is upregulated in other common respiratory infections. The broad activity and low cytotoxicity of this specific alkylamide support its potential use for treating rhinovirus and influenza virus infections.
- Published
- 2025
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18. Enhanced hemocompatibility, antimicrobial and anti-inflammatory properties of biomolecules stabilized AgNPs with cytotoxic effects on cancer cells.
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Chahardoli A, Qalekhani F, Hajmomeni P, Shokoohinia Y, and Fattahi A
- Subjects
- Humans, Anti-Inflammatory Agents pharmacology, Anti-Inflammatory Agents chemistry, MCF-7 Cells, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antioxidants pharmacology, Antioxidants chemistry, Cell Line, Tumor, Plant Extracts pharmacology, Plant Extracts chemistry, Serum Albumin, Bovine chemistry, Microbial Sensitivity Tests, Animals, Particle Size, Blood Coagulation drug effects, Candida albicans drug effects, Silver chemistry, Silver pharmacology, Metal Nanoparticles chemistry, Anti-Infective Agents pharmacology, Anti-Infective Agents chemistry
- Abstract
In the current research, we developed a safe method using Iranian yarrow extract for the synthesis of silver nanoparticles (IY-AgNPs) as reducing and stabilizing agents in different conditions. The prepared and stabilized IY-AgNPs under optimal conditions were characterized using FT-IR, XRD, TEM, and UV-vis techniques. Also, the blood-clotting, hemolytic, antioxidant, bactericidal and, fungicidal properties, cytotoxicity effects and inhibition of protein denaturation efficiency of IY-AgNPs were assessed in vitro. The stabilized IY-AgNPs with spherical shape and an average particle size of 19. 25 ± 7.9 nm did not show any hemolytic potential below 1000 µg/mL. These hemo-compatible NPs showed good blood-clotting ability by reducing clotting time (6 min relative to the control). These particles excellently inhibited the denaturation of bovine serum albumin (BSA) by 69.3-80.7% at concentrations ranging from 31.25 to 500 µg/mL compared to a reference drug. The outcomes showed that the IC50 values of IY-AgNPs were below 12.5 µg/mL against A375 cells and between 25 and 50 µg/mL against MCF-7 cancer cells. In addition, IY-AgNPs were bactericidal against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus (especially), and were fungicidal against Candida albicans. Biosynthesized IY-AgNPs indicated a significant antioxidant activity (63.2%) at a concentration of 350 µg/mL. These attained results suggested that bio/hemo-compatible IY-AgNPs may be a promising candidate for applications in the medicinal fields (particularly for wound healing) as anti-bleeding, antimicrobial, antioxidant, anti-inflammatory, and anticancer agents., Competing Interests: Declarations. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)
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- 2025
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19. Hypertension medication from guidelines to practice: A cohort study in western Iran.
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Shahbazi F, Najafi F, Shojaei L, Farzaei MH, Shokoohinia Y, Pasdar Y, Hamzeh B, Tahvilian R, Rahimi W, Shakiba E, Karim H, Dobson A, Bhatt N, and Moradinazar M
- Subjects
- Humans, Female, Adult, Middle Aged, Aged, Cohort Studies, Iran epidemiology, Blood Pressure, Antihypertensive Agents, Hypertension drug therapy, Hypertension epidemiology
- Abstract
Purpose: Hypertension (HTN) is one of the most common risk factors for non-communicable chronic diseases. The aim of the current study is to evaluate the prescribing patterns of antihypertensive medications in Kermanshah Province, west of Iran., Methods: The Ravansar Non-Communicable Diseases (RaNCD) cohort study is the first Kurdish community-based study; subjects' age ranged from 35 to 65 years. In order to examine the use of medications to control blood pressure, participants were asked to bring all prescribed medications to the study center. Treatments were compared with 2013 European Society of Hypertension (ESH)/European Society of Cardiology (ESC) Guidelines for the management of arterial HTN., Results: From a total of 10 040 participants in RaNCD cohort, 1575 (15.7%) individuals were hypertensive, of whom, 1271 (80.7%) people were aware of their condition. From 1153 (73.20%) people under treatment, 840 (72.8%) had their HTN properly controlled. The most common medications used to treat HTN were losartan (27.5%), metoprolol (14.3%), and captopril (11.9%). Regardless of type of treatment, 49.3% of all patients have received the medication for l 6 ≥ years. The most commonly used drugs were β-blockers and angiotension receptor blockers as 620 (31.0%) and 612 (30.6%), respectively. Multivariable analysis showed that female gender, those receive ≥3 antihypertensive agents, and using preferred combinations were associated with a better blood pressure control. In addition, the probability of hypertension control was less likely with increasing duration of treatment (i.e >6 years) and in obese patients with ≥35 kg/m
2 ., Conclusions: Even though adherence to the international guidelines was acceptable, improvements can be made for better control of HTN. Therefore, it is imperative to educate healthcare professionals on improving their selection of antihypertensive medications and combination therapy for hypertensive patients., (© 2023 John Wiley & Sons Ltd.)- Published
- 2023
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20. The role of quercetin in the formation of titanium dioxide nanoparticles for nanomedical applications.
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Chahardoli A, Jalilian F, Shokoohinia Y, and Fattahi A
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- Humans, Quercetin toxicity, Titanium chemistry, Microscopy, Electron, Transmission, Spectroscopy, Fourier Transform Infrared, Plant Extracts pharmacology, X-Ray Diffraction, Nanoparticles toxicity, Nanoparticles chemistry, Metal Nanoparticles toxicity, Metal Nanoparticles chemistry
- Abstract
The current work aimed to synthesize and characterize titanium dioxide nanoparticles (TiO
2 NPs) using quercetin (QE) and evaluate their biological activities, i.e., anti-hemolytic, anti-inflammatory, and cytotoxicity effects. The crystallographic phase and morphology of biosynthesized QE-TiO2 NPs were characterized by XRD (X-Ray Diffraction) and TEM/FE-SEM (Transmission/Field-Emission Scanning Electron Microscopy) micrographs. Functional groups involved in the synthesis process were determined by FTIR spectroscopy (Fourier Transform-Infrared Spectroscopy). Based on the characterization results, selected QE-TiO2 NPs showed a rutile phase, spherical shape, and a size range of 7.3-39 nm. The QE-TiO2 NPs did not show a hemolytic effect. They indicated 95.3% red blood cells (RBCs) membrane stabilization activity and 82.6% inhibition of bovine serum albumin (BSA) denaturation, similar to a standard drug, which proved their anti-inflammatory effects. The attained results from cytotoxicity studies revealed the toxic effects of QE-TiO2 NPs with IC50 values below 100 and 50 μg/mL for human breast cancer cells of MCF-7 and melanoma cancer cells of A375, respectively. These NPs did not significantly affect normal skin fibroblast cells up to 50 μg/mL and only showed a 16% inhibition rate on the cell viability at 100 μg/mL. These NPs also induced excessive ROS generation. This work established the blood/biocompatibility and excellent nanomedical applications of biosynthesized QE-TiO2 NPs., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)- Published
- 2023
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21. Colchicine of Colchicum autumnale , A Traditional Anti-Inflammatory Medicine, Induces Apoptosis by Activation of Apoptotic Genes and Proteins Expression in Human Breast (MCF-7) and Mouse Breast (4T1) Cell Lines.
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Adham Foumani E, Irani S, Shokoohinia Y, and Mostafaie A
- Abstract
Objective: Breast cancer is one of the major causes of mortality among women. Due to many side effects of the existing chemotherapeutic agents, the research of anti-cancer drugs, including natural products, is still a big challenge. Here, we investigated the effects of colchicine on apoptosis of two breast cancer cell lines ( human MCF-7 and mouse 4T1)., Materials and Methods: In this experimental study, we evaluated the apoptotic effects of colchicine on (MCF-7) and (4T1), as well as a human cancer-associated fibroblast cell line as a control group. Extraction and chromatographic techniques were applied to isolate colchicine from Colchicum autumnale L. To compare the isolated colchicine with pure standard colchicine, we used the H-NMR technique. The methyl thiazolyl tetrazolium (MTT) assay, quantitative reverse transcriptase-polymerase chain reaction, Western blotting and annexin V/PI staining were used to evaluate the apoptotic effects of the isolated and standard colchicine., Results: Similar to standard colchicine, the isolated colchicine inhibited cell proliferation significantly in cancer cell lines. Colchine inhibited proliferation and induced apoptosis on a dose-dependent manner. The medicine modified the expression of genes-related to apoptosis by up-regulation of P53 ,BAX, CASPASE-3, -9 and down-regulation of BCL-2 gene, which led to an increase in the BAX/BCL-2 ratio., Conclusion: We showed that isolated colchicine from Colchicum autumnale and pure standard colchicines modulate the expression levels of several genes and therefore exerting their anticancer effects on both human (MCF-7) and mouse (4T1) breast cancer cells. Based on these results, we suggest that colchicine can be a potential candidate for prevention and treatment of breast cancer.
- Published
- 2022
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22. Effects of Flaxseed on Blood Lipids in Healthy and Dyslipidemic Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
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Sadat Masjedi M, Mohammadi Pour P, Shokoohinia Y, and Asgary S
- Subjects
- Cholesterol, HDL, Cholesterol, LDL, Humans, Lipids, Randomized Controlled Trials as Topic, Triglycerides, Dyslipidemias drug therapy, Flax
- Abstract
To address hyperlipidemia, flaxseed demonstrates a great impact on experimental and clinical trials. Therefore, the effects of flaxseed on lipid profiles of healthy and dyslipidemic subjects were assayed. The literature search was performed based on English reports of randomized control trials (RCTs) up to April 2021 to seek the effect of flaxseed on lipid profiles of healthy and dyslipidemic subjects. A total of 14 RCTs with 1107 participants were evaluated. Based on results, flaxseed significantly improves the lipid profile in dyslipidemic patients comprising total cholesterol (TC), low-density lipoprotein (LDL-C) and triglyceride (TG) in comparison with the control group. Nevertheless, no significant changes were observed in high-density lipoprotein (HDL-C). Although in healthy individual flaxseed significantly increased HDL-C, LDL-C and TG. Subgroup analysis on healthy subjects showed that flaxseed improved LDL-C on overweight subjects with BMI>25. The evidence suggests that flaxseed significantly improved TC, LDL-C and TG in dyslipidemic subjects and additionally improved the HDL-C on healthy subjects., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2022
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23. Differentiating Cannabis Products: Drugs, Food, and Supplements.
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Salehi A, Puchalski K, Shokoohinia Y, Zolfaghari B, and Asgary S
- Abstract
"Hemp" refers to non-intoxicating, low delta-9 tetrahydrocannabinol (Δ9-THC) cultivars of Cannabis sativa L. "Marijuana" refers to cultivars with high levels of Δ9-THC, the primary psychoactive cannabinoid found in the plant and a federally controlled substance used for both recreational and therapeutic purposes. Although marijuana and hemp belong to the same genus and species, they differ in terms of chemical and genetic composition, production practices, product uses, and regulatory status. Hemp seed and hemp seed oil have been shown to have valuable nutritional capacity. Cannabidiol (CBD), a non-intoxicating phytocannabinoid with a wide therapeutic index and acceptable side effect profile, has demonstrated high medicinal potential in some conditions. Several countries and states have facilitated the use of THC-dominant medical cannabis for certain conditions, while other countries continue to ban all forms of cannabis regardless of cannabinoid profile or low psychoactive potential. Today, differentiating between hemp and marijuana in the laboratory is no longer a difficult process. Certain thin layer chromatography (TLC) methods can rapidly screen for cannabinoids, and several gas and liquid chromatography techniques have been developed for precise quantification of phytocannabinoids in plant extracts and biological samples. Geographic regulations and testing guidelines for cannabis continue to evolve. As they are improved and clarified, we can better employ the appropriate applications of this uniquely versatile plant from an informed scientific perspective., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Salehi, Puchalski, Shokoohinia, Zolfaghari and Asgary.)
- Published
- 2022
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24. Glucosinolates and their hydrolysis products as potential nutraceuticals to combat cytokine storm in SARS-COV-2.
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Bahoosh SR, Shokoohinia Y, and Eftekhari M
- Subjects
- Cytokines metabolism, Dietary Supplements, Humans, Hydrolysis, NF-E2-Related Factor 2, NF-kappa B metabolism, Cytokine Release Syndrome drug therapy, Glucosinolates therapeutic use, COVID-19 Drug Treatment
- Abstract
Introduction: The high mortality rate in severe cases of COVID-19 is mainly due to the strong upregulation of cytokines, called a cytokine storm. Hyperinflammation and multiple organ failure comprise the main clinical features of a cytokine storm. Nrf2 is a transcription factor which regulates the expression of genes involved in immune and inflammatory processes. Furthermore, Nrf2, as a master regulator, controls the activity of NF-κB which binds to the promoter of many pro-inflammatory genes inducible of various inflammatory factors. Inhibition of Nrf2 response was recently demonstrated in biopsies from patients with COVID-19, and Nrf2 agonists inhibited SARS-CoV-2 replication across cell lines in vitro. Glucosinolates and their hydrolysis products have excellent anti-inflammatory and antioxidant effects via the Nrf2 activation pathway, reduction in the NF-κB activation, and subsequent reduced cytokines levels., Conclusion: Accordingly, these compounds can be helpful in combating the cytokine storm associated with COVID-19., (© 2022. Springer Nature Switzerland AG.)
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- 2022
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25. Oxypeucedanin and isoimperatorin extracted from Prangos ferulacea (L.) Lindl protect PC12 pheochromocytoma cells from oxidative stress and apoptosis induced by doxorubicin.
- Author
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Jalilian F, Moieni-Arya M, Hosseinzadeh L, and Shokoohinia Y
- Abstract
Background and Purpose: Doxorubicin (DOX) as a chemotherapeutic agent has been widely used in the treatment of various types of cancer. However, DOX exerts a toxic effect on normal tissues such as the brain. Furanocoumarins reduce the risk of cardiovascular and brain diseases because of their antioxidant activities. This study has been designed, for the first time, to evaluate the effect of known furanocoumarins oxypeucedanin and isoimperatorin extracted from Prangos ferulacea (L.) Lindl on oxidative stress and apoptosis induced by DOX toward pheochromocytoma cell line (PC12)., Experimental Approach: NMR and MASS spectrometers were used to characterize the isolated compounds. The protective effects of isolated compounds on DOX-induced cytotoxicity in PC12 cells were examined by MTT assay. PC12 cells were pretreated with oxypeucedanin and isoimperatorin for 2 and 21 h, respectively, subsequently exposure to DOX at IC
50 concentration. Then, mitochondrial membrane potential (MMP), Bax and Bcl2 mRNA expressions, caspase-3 activation, and the generation of intracellular reactive oxygen species (ROS) were measured after 24 h., Findings/results: Pretreatment with oxypeucedanin and isoimperatorin significantly decreased DOX-induced apoptosis through reduction of caspase-3 activity and ROS generation and an increase in MMP. In addition, our finding showed pretreatment with these compounds leads to regulation of Bcl-2., Conclusion and Implications: Taken together our observation indicated that oxypeucedanin and isoimperatorin have a protective effect against apoptosis induced by DOX in PC12 cells by inhibition of ROS production., Competing Interests: The authors declared no conflict of interest in this study., (Copyright: © 2021 Research in Pharmaceutical Sciences.)- Published
- 2021
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26. Optimization of Quercetin-Assisted Silver Nanoparticles Synthesis and Evaluation of Their Hemocompatibility, Antioxidant, Anti-Inflammatory, and Antibacterial effects.
- Author
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Chahardoli A, Hajmomeni P, Ghowsi M, Qalekhani F, Shokoohinia Y, and Fattahi A
- Abstract
In the present study, different effective parameters (temperature, reaction time, and pH) on the synthesis of quercetin-assisted silver nanoparticles (QE-AgNPs) are optimized. These biogenic NPs are characterized by different physico-chemical analyses, including transmission electron microscopy, X-ray diffraction, Fourier transform infrared (FTIR) spectroscopy, and UV-visible spectroscopy. In addition, the biological properties of QE-AgNPs are evaluated through antioxidant, antimicrobial, anti-inflammatory, hemolysis, and coagulation time assays. The formation of QE-AgNPs is affected by different parameters. The optimum condition for the synthesis of QE-AgNPs is attained at 70 °C and pH 7. Prepared QE-AgNPs show a spherical shape with a crystalline nature and an average particle size of 20 ± 3.6 nm. The role of QE as a reducing and capping agent in the preparation process of QE-AgNPs is demonstrated using FTIR analysis. These NPs with excellent antioxidant activity (82.3% at a concentration of 400 µg mL
-1 ) and anti-inflammatory properties (82.5% and 100% at concentrations of 37.25 and 500 µg mL-1 , respectively), show good antimicrobial effects, particularly against Staphylococcus aureus . Furthermore, the results of the hemolytic and coagulation assay of QE-AgNPs indicate their hemo-compatibility. Therefore, hemo/bio-compatible QE-AgNPs with excellent and unique properties can be employed in different medicinal and pharmacological applications., Competing Interests: The authors declare no conflict of interest., (© 2021 The Authors. Global Challenges published by Wiley‐VCH GmbH.)- Published
- 2021
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27. Salvigenin, a Trimethoxylated Flavone from Achillea Wilhelmsii C. Koch, Exerts Combined Lipid-Lowering and Mitochondrial Stimulatory Effects.
- Author
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Serino E, Chahardoli A, Badolati N, Sirignano C, Jalilian F, Mojarrab M, Farhangi Z, Rigano D, Stornaiuolo M, Shokoohinia Y, and Taglialatela-Scafati O
- Abstract
Phytochemical analysis of the Iranian plant Achillea wilhelmsii led to the isolation of 17 pure secondary metabolites belonging to the classes of sesquiterpenoids and phenolics. Two of these compounds, named wilhemsin ( 7 ) and wilhelmsolide ( 9 ), are new sesquiterpenoids, and the first shows undescribed structural features. Their structures were elucidated through extensive spectroscopic analysis, mainly based on 1D and 2D NMR, and chemical derivatization. Starting from plant traditional use and previous reports on the activity of the plant extracts, all the pure compounds were evaluated on endpoints related to the treatment of metabolic syndrome. The sesquiterpene hanphyllin ( 8 ) showed a selective cholesterol-lowering activity (-12.7% at 30 µM), santoflavone ( 13 ) stimulated glucose uptake via the GLUT transporter (+16.2% at 30 µM), while the trimethoxylated flavone salvigenin ( 14 ) showed a dual activity in decreasing lipid levels (-22.5% palmitic acid biosynthesis at 30 µM) and stimulating mitochondrial functionality (+15.4% at 30 µM). This study further confirms that, in addition to the antioxidants vitexin, isovitexin, and isoschaftoside, A. wilhelmsii extracts contain molecules that can act at different levels on the metabolic syndrome symptoms.
- Published
- 2021
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28. Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury.
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Majnooni MB, Fakhri S, Shokoohinia Y, Kiyani N, Stage K, Mohammadi P, Gravandi MM, Farzaei MH, and Echeverría J
- Abstract
Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, millions of people have been infected and died worldwide. However, no drug has been approved for the treatment of this disease and its complications, which urges the need for finding novel therapeutic agents to combat. Among the complications due to COVID-19, lung injury has attained special attention. Besides, phytochemicals have shown prominent anti-inflammatory effects and thus possess significant effects in reducing lung injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, the prevailing evidence reveales the antiviral effects of those phytochemicals, including anti-SARS-CoV activity, which could pave the road in providing suitable lead compounds in the treatment of COVID-19. In the present study, candidate phytochemicals and related mechanisms of action have been shown in the treatment/protection of lung injuries induced by various methods. In terms of pharmacological mechanism, phytochemicals have shown potential inhibitory effects on inflammatory and oxidative pathways/mediators, involved in the pathogenesis of lung injury during COVID-19 infection. Also, a brief overview of phytochemicals with anti-SARS-CoV-2 compounds has been presented., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2020 Majnooni, Fakhri, Shokoohinia, Kiyani, Stage, Mohammadi, Gravand, Farzaei and Echeverria.)
- Published
- 2020
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29. Biological and Catalytic Activities of Green Synthesized Silver Nanoparticles from the Leaf Infusion of Dracocephalum kotschyi Boiss.
- Author
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Chahardoli A, Qalekhani F, Shokoohinia Y, and Fattahi A
- Abstract
The discovery and development of active compounds to eliminate drug resistance and side effects is a crucial process. In this study, the leaf infusion of Dracocephalum kotschyi Boiss as a novel green alternative is used to synthesize silver nanoparticles (Drac-AgNPs). Antibacterial, cytotoxicity effects, hemocompatibility, and the catalytic properties of these nanoparticles are evaluated. The synthesis of Drac-AgNPs is confirmed by UV-vis spectroscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, and transmission electron microscopy, where Drac-AgNPs are spherical, with a size range of 5-63 nm. Their IC
50 values against H1299 and MCF-7 cell lines are above 50 and 100 μg mL-1 , respectively. Drac-AgNPs are effective against an inclusive range of the gram-positive and gram-negative bacteria, that is, Staphylococcus epidermidis , Staphylococcus aureus , Bacillus subtilis , Escherichia coli , Serratia marcescens , and Pseudomonas aeruginosa , and a low hemolytic effect makes them an exceptional AgNP with a great hemocompatibility. They show a moderate catalytic-effect in terms of removing methylene blue, with 67% degradation. Altogether, Drac-AgNP, as a multi-tasker material, shows potential for the prevention and treatment of infections and photothermal/chemotherapy of cancers., Competing Interests: The authors declare no conflict of interest., (© 2020 The Authors. Published by Wiley‐VCH GmbH.)- Published
- 2020
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30. Comparison of the cytotoxic effects of different fractions of Artemisia ciniformis and Artemisia biennis on B16/F10, PC3 and MCF7 Cells.
- Author
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Ramazani E, Tayarani-Najaran Z, Shokoohinia Y, and Mojarrab M
- Abstract
Background and Purpose: Artemisia is one of the well-known herbal medicinal plants for antimicrobial, insecticidal, antioxidant, and antimalarial activities. The antiproliferative effects of dichloromethane extracts of Artemisia biennis ( A. biennis ) and A. ciniformis and the petroleum ether extract of A. ciniformis have been demonstrated previously on human cancerous cell lines. In the current study, further fractionation was carried out on the aforementioned extracts and their cytotoxic effects were evaluated on three human cancer cell lines; B16/F10, PC3, and MCF7. F1 to F16, F1' to F11', and F1" to F10" were resulted from the fractionation of dichloromethane extracts of A. biennis, A. ciniformis , and petroleum ether extract of A. ciniformis , respectively., Experimental Approach: The cytotoxic effects of 16 (F1-F16), 11 (F1'-F11') and 10 (F1"-F10") fractions, on B16/F10, PC3, and MCF7 cell lines were assessed using resazurin to measure viability and propidium iodide staining (sub G1) and flow cytometry to detect apoptosis., Findings / Results: The results showed that, some fractions at 100 μg/mL decreased cell viability. F2" in B16/F10 cells, F2, F4-F6, F10', F11', and F2" in PC3 cells, and F10', F11', and F2" in MCF7 significantly decreased cell viability in a concentration-dependent manner (12.5-50 μg/mL). Among different fractions, F2" demonstrated the most potent cytotoxic effects on cancer cell lines ( P < 0.001). All of the mentioned fractions (except F11' on PC3 cells) increased the number of apoptotic cells and showed the cytotoxic effects on cancer cells compared with the control group., Conclusion and Implications: A. biennis and A. ciniformis are suggested as the potential sources of cytotoxic phytochemicals. The probable presence of terpenoids, steroids, and alkaloids in the selected fractions is proposed based on the preliminary phytochemical study., Competing Interests: The authors declare no conflict of interest for this study., (Copyright: © 2020 Research in Pharmaceutical Sciences.)
- Published
- 2020
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31. Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties.
- Author
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Majnooni MB, Fakhri S, Shokoohinia Y, Mojarrab M, Kazemi-Afrakoti S, and Farzaei MH
- Subjects
- Animals, Anti-Inflammatory Agents isolation & purification, Anti-Inflammatory Agents pharmacokinetics, Antineoplastic Agents isolation & purification, Antineoplastic Agents pharmacokinetics, Antioxidants isolation & purification, Antioxidants pharmacokinetics, Cardiotonic Agents isolation & purification, Cardiotonic Agents pharmacokinetics, Coumarins chemical synthesis, Coumarins chemistry, Coumarins pharmacokinetics, Eleutherococcus chemistry, Fraxinus chemistry, Humans, Matrix Metalloproteinases metabolism, NF-kappa B metabolism, Neuroprotective Agents isolation & purification, Neuroprotective Agents pharmacokinetics, Solvents chemistry, Tumor Necrosis Factor-alpha metabolism, Anti-Inflammatory Agents pharmacology, Antineoplastic Agents pharmacology, Antioxidants pharmacology, Cardiotonic Agents pharmacology, Coumarins isolation & purification, Coumarins pharmacology, Neuroprotective Agents pharmacology
- Abstract
Isofraxidin (7-hydroxy-6, 8-dimethoxy coumarin) (IF) is a hydroxy coumarin with several biological and pharmacological activities. The plant kingdom is of the most prominent sources of IF, which, among them, Eleutherococcus and Fraxinus are the well-known genera in which IF could be isolated/extracted from their species. Considering the complex pathophysiological mechanisms behind some diseases (e.g., cancer, neurodegenerative diseases, and heart diseases), introducing IF as a potent multi-target agent, which possesses several herbal sources and the multiple methods for isolation/purification/synthesis, along with the unique pharmacokinetic profile and low levels of side effects, could be of great importance. Accordingly, a comprehensive review was done without time limitations until February 2020. IF extraction methods include microwave, mechanochemical, and ultrasound, along with other conventional methods in the presence of semi-polar solvents such as ethyl acetate (EtOAc). In addition to the isolation methods, related synthesis protocols of IF is also of great importance. From the synthesis point of view, benzaldehyde derivatives are widely used as precursors for IF synthesis. Along with the methods of isolation and biosynthesis, IF pharmacokinetic studies showed hopeful in vivo results of its rapid absorption after oral uses, leading to different pharmacological effects. In this regard, IF targets varieties of inflammatory mediators including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tumor necrosis factor-α (TNF-α), and matrix metalloproteinases (MMPs). thereby indicating anticancer, cardioprotective, and neuroprotective effects. This is the first review on the synthesis, biosynthesis, isolation, and pharmacokinetic and pharmacological properties of IF in combating different diseases.
- Published
- 2020
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32. One-step Synthesized Silver Nanoparticles Using Isoimperatorin: Evaluation of Photocatalytic, and Electrochemical Activities.
- Author
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Mavaei M, Chahardoli A, Shokoohinia Y, Khoshroo A, and Fattahi A
- Abstract
In the current study, isoimperatorin, a natural furanocoumarin, is used as a reducing reagent to synthesize isoimperatorin mediated silver nanoparticles (Iso-AgNPs), and photocatalytic and electrocatalytic activities of Iso-AgNPs are evaluated. Iso-AgNPs consisted of spherically shaped particles with a size range of 79-200 nm and showed catalytic activity for the degradation (in high yields) of New Fuchsine (NF), Methylene Blue (MB), Erythrosine B (ER) and 4-chlorophenol (4-CP) under sunlight irradiation. Based on obtained results, Iso-AgNPs exhibited 96.5%, 96.0%, 92%, and 95% degradation rates for MB, NF, ER, and 4-CP, respectively. The electrochemical performance showed that the as-prepared Iso-AgNPs exhibited excellent electrocatalytic activity toward hydrogen peroxide (H
2 O2 ) reduction. It is worth noticing that the Iso-AgNPs were used as electrode materials without any binder. The sensor-based on binder-free Iso-AgNPs showed linearity from 0.1 µM to 4 mM with a detection limit of 0.036 μM for H2 O2 . This binder-free and straightforward strategy for electrode preparation by silver nanoparticles may provide an alternative technique for the development of other nanomaterials based on isoimperatorin under green conditions. Altogether, the application of isoimpratorin in the synthesis of nano-metallic electro and photocatalysts, especially silver nanoparticles, is a simple, cost-effective and efficient approach.- Published
- 2020
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33. Antidiabetic Potential of Prosopis farcta Roots: In Vitro Pancreatic Beta Cell Protection, Enhancement of Glucose Consumption, and Bioassay-Guided Fractionation.
- Author
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Shahbazi B, Feyzmand S, Jafari F, Ghiasvand N, Bahrami G, Fattahi A, Habtemariam S, Nabavi SM, and Shokoohinia Y
- Abstract
By using the streptozotocin- (STZ-) induced cytotoxicity in β -TC3 cells as an assay model, a bioassay-guided fractionation study was employed to isolate and characterize the potential antidiabetic principles of roots of Prosopis farcta. A combination of open column chromatography on reverse-phase silica gel using a water-ethanol gradient (10 : 90 to 100 : 0) followed by HPLC-based fractionation led to an active compound that appears to be composed of carbohydrate/sugar. When cell viability under STZ was reduced to 49.8 ± 4% (mean ± SD), treatment with the active compound at the concentration of 0.5 mg/mL either as a coadministration or a pretreatment improved the viability to 93 ± 1.9% and 91.5 ± 7%, respectively. The reduction in the mitochondrial membrane potential by STZ (47.34 ± 8.9% of control) was similarly recovered to 84.5 ± 4.3 (coadministration) and 88 ± 5.5% (pretreatment) by the active fraction. The bioassay-guided fractionation, β -cell protective effect, and increased glucose consumption (up to 1.49-fold increase) in hepatocytes by the extracts and active fraction are also discussed., Competing Interests: The authors declare that they do not have any conflicts of interest regarding the publication of this study., (Copyright © 2020 Behzad Shahbazi et al.)
- Published
- 2020
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34. Cytotoxic and Apoptogenic Sesquiterpenoids from the Petroleum Ether Extract of Artemisia aucheri Aerial Parts.
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Hosseinzadeh L, Shokoohinia Y, Arab M, Allahyari E, and Mojarrab M
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Different types of Artemisia aucheri extracts were reported to have various biological activities including a cytotoxic effect on some cancer cell lines. We investigated the antiproliferative activity of isolated sesquiterpenoids from petroleum ether extract of Artemisia aucheri ( A. aucheri ) aerial parts on SK-N-MC, MCF-7, and A2780 cell lines. Phytochemicals from the petroleum ether cold macerated extract were isolated using normal phase vacuum liquid chromatography and high pressure liquid chromatography (VLC and HPLC) and the structures of the components were determined by spectroscopic means. Cell viability was determined by 3-(4,5- dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay. Activation of caspases-3 and -9 was evaluated using a spectrophotometer. Mitochondrial membrane potential (MMP) was measured using rhodamine 123 fluorescent dye. Two tetrahydrofuran- type sesquiterpenoids, hydroperoxide of davanone (1) and hydroxydavanone (2) were isolated and characterized. Between these compounds, compound 1 exhibited more potent activity against the MCF-7, SK-N-MC and A2780 cell lines with IC
50 values of 8.45 ± 0.81 µg/mL, 9.60 ± 1.32 µg/mL and 10.9 ± 2.03 µg/mL in A2780, MCF-7 and SK-N-MC cells, respectively. Compound 1 inhibited the growth of human cancer cells by induction of apoptosis. To the best of our knowledge, this is the first comprehensive study on cytotoxic and apoptotic mechanism of two davanone derivatives isolated from A. aucheri in human cancer cells. Overall, our data suggest that hydroperoxide of davanone (1) should be further studied in-vivo as a potential antitumor agent.- Published
- 2019
35. Preparation and Characterization of Silk Fibroin Nanoparticles as a Potential Drug Delivery System for 5-Fluorouracil.
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Rahmani H, Fattahi A, Sadrjavadi K, Khaledian S, and Shokoohinia Y
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Purpose: The aim of this study is to prepare 5-fluorouracil (5-FU) loaded silk fibroin nanoparticles (SFNPs) and to achieve a controlled release delivery system with the high loading capacity. Methods: SFNPs with 1:1, 1:3, and 1:10 ratios of 5-FU to silk fibroin were prepared. SFNPs were characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) analysis, Scanning electron microscope (SEM), and Transmission electron microscope (TEM). Loading efficiency, in vitro release, and cell viability were studied for optimal SFNPs. Results: The ratio of 1:1 was optimal formulation with the size and polydispersity index (PDI) of 221.03 nm and 0.093 before freeze drying, and 286.7 nm and 0.154 after freeze drying by lactose, respectively. The loading efficiency and loading content of this ratio were 52.32% and 34.35%, respectively. FT-IR and XRD analysis indicated the conformational change (from random coil to β-sheet) in the structure of nanoparticles by increasing amount of the drug, which caused the smaller size, the higher loading efficiency, and the slower release pattern. The drugloaded nanoparticles reached to the half maximal inhibitory concentration (IC50) that were comparable with free drug on MCF7 (human breast cancer) cell line. Conclusion: This study was planned to achieve a promising controlled release drug delivery system for carrying 5-FU, as a potent anticancer drug. SFNPs were found proper candidates for delivery of a hydrophilic drug such as 5-FU., (© 2019 The Author (s).)
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- 2019
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36. Ugi efficient synthesis, biological evaluation and molecular docking of coumarin-quinoline hybrids as apoptotic agents through mitochondria-related pathways.
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Taheri S, Nazifi M, Mansourian M, Hosseinzadeh L, and Shokoohinia Y
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- Female, Humans, Membrane Potential, Mitochondrial, Mitochondria metabolism, Molecular Docking Simulation, Ovarian Neoplasms drug therapy, Reactive Oxygen Species metabolism, Tumor Cells, Cultured, Antineoplastic Agents chemical synthesis, Antineoplastic Agents pharmacology, Apoptosis, Benzopyrans chemical synthesis, Benzopyrans pharmacology, Coumarins chemistry, Mitochondria drug effects, Ovarian Neoplasms pathology, Quinolines chemistry
- Abstract
Ugi reaction was a reliable procedure for the synthesis of new coumarin-quinoline frameworks. Excellent yields, mild reaction conditions and easily available and inexpensive starting materials are advantages of this protocol. Cytotoxic effects of fourteen products were investigated in A2780 human ovarian cancer cells. Two synthesized compounds (L11 and L12) exhibited more anti-cancer activity than other derivatives with IC
50 values of 0.042 mmol/L and 0.102 mmol/L, respectively and were thus selected for further studies. Apoptosis was induced through the intrinsic pathway by activating caspase 9 and ended at the executioner pathway of caspase 3. Measurement of intracellular reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were also carried out for both of them. Further studies on a mechanism by Real Time-PCR and Western blot analysis were performed for anti-apoptotic proteins Bcl-2 and survivin both in mRNA and protein level relating to the untreated A2780 cells. The treatment of A2780 cells with compound L11 significantly (P-value ≤ 0.05) induced apoptosis by down-regulation of Bcl-2 and survivin both in mRNA and protein level via a single dose (0.042 mmol/L), as well as activation of caspase 9 and 3, loss of MMP, and high ROS. Accordingly, findings supported the first report under which the pro-apoptotic activity of compound L11 as an apoptosis-inducing agent was related to mitochondrial-mediated dysfunction signaling pathways. Molecular docking supports experimental outcomes. Evidently, coumarin-quinoline scaffolds are potentially favorable options for further assessment as influential chemotherapeutic agents for the future., (Copyright © 2019 Elsevier Inc. All rights reserved.)- Published
- 2019
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37. Efficacy and safety of Achillea wilhelmsii C. Koch capsules on symptom severity and quality of life in patients with irritable bowel syndrome: a randomized, placebo-controlled clinical trial.
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Derakhshande P, Navabi SJ, Shokoohinia Y, Rouhi-Broujeni H, Deris F, Behbood L, Shahbazi F, Amiri M, and Farzaei MH
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- Adult, Capsules, Double-Blind Method, Female, Humans, Male, Middle Aged, Phytotherapy, Quality of Life, Surveys and Questionnaires, Young Adult, Achillea chemistry, Irritable Bowel Syndrome drug therapy, Plant Preparations therapeutic use
- Abstract
Background Irritable bowel syndrome (IBS) is one of the most common digestive diseases. The aim of this clinical trial was to determine the effectiveness of Achillea wilhelmsii C. Koch on the symptom severity and quality of life (QOL) in patients with IBS. Methods The patients were randomized into two groups of 45 each. The QOL and symptom severity of the patients were evaluated at baseline and at completion of the treatments by means of IBS-QOL and IBS severity index. Results The mean severity of clinical symptoms in the Achillea wilhelmsii C. Koch receiving groups before and after the treatment was 282.56 ± 103.57 and 178.06 ± 88.40, and in the placebo group was 265.93 ± 93.56 and 197.74 ± 106.26, respectively. The mean QOL in the Achillea wilhelmsii C. Koch receiving group before and after treatment was 51.49 ± 11.98 and 50.44 ± 13.39 and in the placebo group was 60.71 ± 11.97 and 58.39 ± 11.67, respectively. In both groups, there was a significant difference in the recovery rate in each group (p<0.05). However, the mean difference between the two groups before and after intervention was not significantly different (p>0.05). Also, no patient reported any adverse events during the trial. Although the symptom severity and QOL in both groups were improved compared to those before intervention, there was no significant difference between the two groups. Conclusion It is recommended to conduct future studies with larger sample size and longer treatment periods, and also investigate the efficacy on the IBS subtypes, separately.
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- 2019
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38. Efficacy and safety of a standardized extract from Achillea wilhelmsii C. Koch in patients with ulcerative colitis: A randomized double blind placebo-controlled clinical trial.
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Amiri M, Navabi J, Shokoohinia Y, Heydarpour F, Bahrami G, Behbood L, Derakhshandeh P, Momtaz S, and Farzaei MH
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- Administration, Oral, Adult, C-Reactive Protein metabolism, Caffeic Acids adverse effects, Caffeic Acids therapeutic use, Colitis, Ulcerative metabolism, Double-Blind Method, Erythrocytes drug effects, Female, Hemoglobins drug effects, Humans, Male, Platelet Count methods, Achillea adverse effects, Achillea chemistry, Colitis, Ulcerative drug therapy, Plant Extracts adverse effects, Plant Extracts therapeutic use
- Abstract
Background: Using Achillea wilhelmsii as a dietary supplement for gastrointestinal disorders is common in Persian traditional medicine. Its anti-inflammatory, anti-spasmodic and antibacterial properties have been proven by different in vitro and in vivo studies, yet it has not been evaluated in a controlled clinical trial., Aim: This study intended to evaluate the efficacy and safety of A. wilhelmsii in patients with mild to moderate active ulcerative colitis in a randomized, double-blinded, placebo-controlled clinical trial. The hydroalcoholic extract of A. wilhelmsii was standardized based on caffeic acid., Methods: Forty-nine patients were randomly received A. wilhelmsii capsules or placebo, twice daily for 4 weeks in a 1:1 ratio. The disease activity index (DAI) (Partial Mayo Score), haemoglobin, platelet count, erythrocyte sedimentation rate (ESR) and serum level of C-reactive protein (CRP) were measured at the entry and the end of the treatment. To standardize the extract, caffeic acid was detected and measured in the plant extract using high performance liquid chromatography (HPLC)., Results: Of 49 patients who entered the trial, 40 patients completed the study. In both treatment and placebo groups, significant reductions were observed in stool frequency, rectal bleeding, physician global assessment and partial mayo score. There was no significant difference in stool frequency (P = 0.176), rectal bleeding (P = 0.523), physician global assessment (P = 0.341) and partial mayo score (P = 1) in the treatment versus the placebo groups. Laboratory variables including hemoglobin, platelet count, ESR and CRP showed no significant difference between the treatment and the placebo group. Of all participants, only one patient in the treatment group complained about skin rash (grade 1 based on the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0)., Conclusion: Oral administration of A. wilhelmsii powder for 4 weeks did not create a clinical response more than placebo. It seemed to be safe in UC patients. Further studies are obligatory to evaluate the therapeutic potential of A. wilhelmsii in the form of extract in UC patients., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
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- 2019
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39. TRPA1 Modulating C 14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba .
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Chianese G, Sirignano C, Shokoohinia Y, Mohammadi Z, Bazvandi L, Jafari F, Jalilian F, Schiano Moriello A, De Petrocellis L, Taglialatela-Scafati O, and Rigano D
- Subjects
- HEK293 Cells, Humans, Iran, Sesquiterpenes chemistry, Sesquiterpenes pharmacology, TRPA1 Cation Channel metabolism, Apiaceae chemistry, Polyynes chemistry, Polyynes pharmacology, TRPA1 Cation Channel antagonists & inhibitors
- Abstract
Phytochemical investigation of the apolar extract obtained from aerial parts of the Iranian endemic plant Echinophora platyloba DC (Apiaceae) resulted in the characterization of the polyacetylene fraction of this plant. This resulted to be composed of the known echinophorins A and B, embedding the very rare α-pyrone terminal, and of the new echinophorin D ( 3 ), including also three conjugated triple bonds. The chemical structures of these compounds were secured by detailed inspection of MS and 1D/2D NMR spectra. The isolated polyacteylenes were evaluated for their modulation of six thermo-TRP channels and they revealed a selective activity on TRPA1, an ion channel involved in the mediation of neuropathic and inflammatory pain. This is the first report on the activity of plant polyacetylenes on transient receptor potential (TRP) channels.
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- 2018
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40. Preparation and physicochemical characterization of camptothecin conjugated poly amino ester-methyl ether poly ethylene glycol copolymer.
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Fattahi A, Karimi N, Rahmati F, Shokoohinia Y, and Sadrjavadi K
- Abstract
In the present study, camptothecin grafted poly amino ester-methyl ether polyethylene glycol (CPT-PEA-MPEG) as a novel copolymer was synthesized by Michael reaction at different ratios of MPEG and CPT (60 : 40 and 80 : 20). The microemulsion was used to prepare nanomicelles, and in vitro cytotoxicity was performed on the HT29 cell line, and cell survival was measured by MTT assay. The syntheses were confirmed by
1 H NMR and FT-IR. Several characterization methods including CMC, particle size, size distribution, and transmission electron microscopy were performed to evaluate features of prepared nanomicelles. Low critical micelle concentration, small particle size and IC50 of 0.1 mg ml-1 at MPEG to CPT ratio of 60 : 40 make this micelle a promising drug delivery carrier. CPT-PAE-MPEG nanomicelles at a MPEG : CPT ratio of 60 : 40 can be a suitable choice to improve the physiochemical properties of CPT and its therapeutic effect, while it can be potentially used as a nano-carrier for other anticancer drugs to purpose a dual drug delivery., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)- Published
- 2018
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41. Preparation and characterization of silk fibroin hydrogel as injectable implants for sustained release of Risperidone.
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Ebrahimi A, Sadrjavadi K, Hajialyani M, Shokoohinia Y, and Fattahi A
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- Chemistry, Pharmaceutical, Delayed-Action Preparations, Drug Delivery Systems, Drug Liberation, Methanol chemistry, Microscopy, Electron, Scanning, Spectroscopy, Fourier Transform Infrared, Thermogravimetry, Transition Temperature, X-Ray Diffraction, Antipsychotic Agents administration & dosage, Fibroins chemistry, Hydrogels chemistry, Risperidone administration & dosage, Silk chemistry
- Abstract
The principal objective of the present study is to achieve a depot formulation of Risperidone by gelation of silk fibroin (SF). For this purpose, hydrochloric acid (HCl)/acetone-based and methanol-based hydrogels were prepared with different drug/polymer ratios (1:3, 1:6, and 1:15). For all the drug-loaded methanol-based hydrogels, gel transition of SF solutions occurred immediately and the gelation time was 1 min, while the gelation time of HCL/acetone-based hydrogels was around 360 min. According to the results obtined from Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) spectra, solvent systems and Risperidone could induce β-sheet structure, but HCL/acetone system had the lowest effect on induction of β-sheets. The crystallinity was increased by increasing the amount of Risperidone, and drug to polymer ratio of 1:3 possessed the highest crystallinity. Thermogravimetric analysis (TGA) indicated that increasing the amount of drug in formulation increased the stability of hydrogels, and methanol-based hydrogel with a ratio of 1:3 had the most stable structure. The release rate of Risperidone from methanol-based hydrogel at ratio of 1:3 was lower than that for HCl/acetone-based one, and it decreased by increasing the amount of Risperidone. The release of Risperidone from methanol hydrogel at ratios 1:3 and 1:6 continued up to 25 d which is acceptable for depot form of Risperidone and shows that the extended release of Risperidone was achieved successfully. In conclusion, SF hydrogel with the ability to respond to the environmental stimuli is an excellent candidate for injectable implants for extended release of Risperidone.
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- 2018
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42. Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review.
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Shokoohinia Y, Jafari F, Mohammadi Z, Bazvandi L, Hosseinzadeh L, Chow N, Bhattacharyya P, Farzaei MH, Farooqi AA, Nabavi SM, Yerer MB, and Bishayee A
- Subjects
- Animals, Apoptosis drug effects, Cell Proliferation drug effects, Humans, Neoplasms metabolism, Neoplasms pathology, Signal Transduction drug effects, Antineoplastic Agents, Phytogenic pharmacology, Coumarins pharmacology, Neoplasms drug therapy
- Abstract
Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and significantly higher off-target effects cause millions of deaths every year. Osthol is a natural coumarin isolated from Apiaceaous plants which has demonstrated several pharmacological effects, such as antineoplastic, anti-inflammatory and antioxidant properties. We have attempted to summarize up-to-date information related to pharmacological effects and molecular mechanisms of osthol as a lead compound in managing malignancies. Electronic databases, including PubMed, Cochrane library, ScienceDirect and Scopus were searched for in vitro, in vivo and clinical studies on anticancer effects of osthol. Osthol exerts remarkable anticancer properties by suppressing cancer cell growth and induction of apoptosis. Osthol's protective and therapeutic effects have been observed in different cancers, including ovarian, cervical, colon and prostate cancers as well as chronic myeloid leukemia, lung adenocarcinoma, glioma, hepatocellular, glioblastoma, renal and invasive mammary carcinoma. A large body of evidence demonstrates that osthol regulates apoptosis, proliferation and invasion in different types of malignant cells which are mediated by multiple signal transduction cascades. In this review, we set spotlights on various pathways which are targeted by osthol in different cancers to inhibit cancer development and progression., Competing Interests: The authors declare no conflict of interest.
- Published
- 2018
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43. Mechanistic In vitro Evaluation of Prosopis farcta Roots Potential as an Antidiabetic Folk Medicinal Plant.
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Feyzmand S, Shahbazi B, Marami M, Bahrami G, Fattahi A, and Shokoohinia Y
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Objective: Prosopis farcta has been used as a traditional herbal medicine for treating Diabetes mellitus . The aim of this study is to investigate the antidiabetic mechanisms of infusion (INF) extract of P. farcta and discovering the active extract for the first time., Materials and Methods: Six different extracts of P. farcta were prepared using five different solvents (ethanol, n -hexane, acetone, ethanol:water (1:1 v/v), and water). Cytotoxicity and cell proliferation assays were performed on mouse pancreatic β-cells (β-TC
3 ) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium method. The effects of P. farcta on glucose metabolism (in a hepatocellular carcinoma cell line [HepG2]) and glucose diffusion across a dialysis membrane (as a model of cellular glucose absorption) were evaluated. The protective effect of various P. farcta extracts on cytotoxicity, mitochondrial membrane potential (MMP), and streptozotocin (STZ)-induced apoptosis in β-TC3 cells was investigated., Results: Cytotoxicity study indicated that extracts were safe on β-TC3 and HepG2 (≤0.5 mg/ml). INF protected β-TC3 cells from apoptosis induced by STZ and improved cell viability for 20% and significantly decrease depolarization of MMP ( P < 0.005). The results showed that INF inhabited breaking/streaking the DNA. Proliferation study showed no significant increase in the number of cells either at single or multiple doses. In moderate hyperglycemia (11.1 mmol/l), a significant glucose-lowering effect was observed but glucose diffusion was not the probable mechanism of extracts antidiabetic effect. In conclusion, only INF, the traditionally used extract, has an antidiabetic potential by attenuating the death and apoptosis induced by STZ in β-TC3 cells and increase glucose consumption., Conclusion: The present study demonstrates that only INF extract have an antidiabetic potential by attenuating the death and apoptosis induced by STZ in β-TC3 cells and increase glucose consumption., Summary: Six different extracts from P. farcta were prepared using five different solvents [ethanol, n-hexane, acetone, ethanol: water (1:1 v/v), and water]The protective effect of various P. farcta extracts on cytotoxicity, mitochondrial membrane potential (MMP), and Streptozotocin-induced apoptosis in β-TC3 cells were investigated.Infusion has an antidiabetic potential by attenuating the death and apoptosis induced by STZ in β-TC3 cells and increase glucose consumptionThe effect of infusion extract on glucose consumption in hepatocellular carcinoma cell line cells (a) and effect of infusion extract on glucose consumption in hepatocellular carcinoma cell line cells adjusted by optical density MTT (b). Significance was calculated by analysis of variance (* P ≤ 0.05). MTT: 3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyltetrazolium. Abbreviations used: AC: Acetone extract; ANOVA: Analysis of variance; BSA: Bovine serum albumin; β-TC3 : Mouse pancreatic β-cells; DMEM: Dulbecco modified Eagle medium; DMSO: Dimethyl sulfoxide; ETH: Ethyl acetate extract; FBS: Fetal bovine serum; HDETH: Hydroethanolic extract; HepG2: Hepatocellular carcinoma cell line; HEX: Hexane extract; INF: Infusion; KUMS: Kermanshah University of Medical Sciences; MMP: Mitochondrial membrane potential; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium; NaCl: Natrium chloride; OD: Optical density; spp: Species; STZ: Streptozotocin; Tag: T-antigen; USA: United States of America., Competing Interests: There are no conflicts of interest.- Published
- 2018
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44. Bioassay-guided Isolation of Neuroprotective Fatty Acids from Nigella sativa against 1-methyl-4-phenylpyridinium-induced Neurotoxicity.
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Hosseinzadeh L, Monaghash H, Ahmadi F, Ghiasvand N, and Shokoohinia Y
- Abstract
Objective: Parkinson's disease, a slowly progressive neurological disease, is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine. The main aspects of researches are the protection of normal neurons against degeneration. Fatty acids (FAs), the key structural elements of dietary lipids, are carboxylic straight chains and notable parameters in nutritional and industrial usefulness of a plant., Materials and Methods: Black cumin, a popular anti-inflammatory and antioxidant food seasoning, contains nonpolar constituents such as FAs which were extracted using hexane. Different fractions and subfractions were apt to cytoprotection against apoptosis and inflammation induced by 1-methyl-4-phenylpyridinium (MPP
+ ) in rat pheochromocytoma cell line (PC12) as a neural cell death model. The experiment consisted of examination of cell viability assessment, mitochondrial membrane potential (MMP), caspase-3 and -9 activity, and measurement of cyclooxygenase (COX) activity., Results: MPP+ induced neurotoxicity in PC12 cells. Pretreatment with subfractions containing FA mixtures attenuated MPP+ -mediated apoptosis partially dependent on the inhibition of caspase-3 and -9 activity and increasing the MMP. A mixture of linoleic acid, oleic acid, and palmitic acid also decreased the COX activity induced by MPP+ in PC12 cells., Conclusion: Our observation indicated that subtoxic concentration of FA from Nigella sativa may exert cytoprotective effects through their anti-apoptotic and anti-inflammation actions and could be regarded as a dietary supplement., Summary: MPP+ induced neurotoxicity in PC12 cells Nigella sativa contains bioactive fatty acidsPretreatment with fatty acids attenuated MPP+ mediated apoptosis through inhibition of caspase 3 and 9 activityA mixture of linoleic acid, oleic acid, and palmitic acid decreased the COX activity induced by MPP+ in PC12 cellsDue to cytoprotective, anti apoptotic and anti inflammation actions of N. sativa , it could be regarded as a dietary supplement. Abbreviations used: ANOVA: Analysis of variance; Ca: Calcium; CDCl3: Chloroform; COX: Cyclooxygenase; DMSO: Dimethyl sulfoxide; EA: Elidic acid; EDTA: Ethylene diamine tetraacetic acid; ELISA: Enzyme Linked Immunosorbent Assay; ESI-MS: Electron spray mass spectroscopy; FAs: Fatty acids; FBS: Fetal bovine serum; GC: Gas chromatography; 1HNMR: Hydrogen nuclear magnetic resonance; LA: Linoleic acid; MPP+: 1-Methyl-4-phenylpyridinium; MPTP: 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MTT: 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide; N. sativa : Nigella sativa ; OA: Oleic acid; PA: Palmitic acid; PBS: Phosphate buffer saline; PC12: Rat pheochromocytoma cell line; PD: Parkinson's disease; PDA: Photo diode array detector; PGE2: Prostaglandin E2; TLC: Thin layer chromatography; TMPD: N,N,N',N'-tetramethyl-p-phenylenediamine; USA: United states of America., Competing Interests: There are no conflicts of interest.- Published
- 2017
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45. New polyacetylenes from Echinophora cinerea (Boiss.) Hedge et Lamond.
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Jelodarian Z, Shokoohinia Y, Rashidi M, Ghiasvand N, Hosseinzadeh L, and Iranshahi M
- Subjects
- Antineoplastic Agents chemistry, Antineoplastic Agents isolation & purification, Antineoplastic Agents pharmacology, Cell Line, Tumor, Coumarins chemistry, Coumarins isolation & purification, Coumarins pharmacology, Flavonoids chemistry, Glycosides chemistry, Glycosides isolation & purification, Glycosides pharmacology, Humans, MCF-7 Cells, Medicine, Traditional, Molecular Structure, Plant Components, Aerial chemistry, Polyynes chemistry, Polyynes pharmacology, Prenylation, Apiaceae chemistry, Cell Death drug effects, Polyynes isolation & purification
- Abstract
Echinophora cinerea aerial parts are used in folk medicine to cure gastric diseases and as a food seasoning in cheese and yogurt. Besides several pharmacological effects have been assigned to Echinophora spp., there is no phytochemical investigation on this genus other than our previous publication on flavonoids. An acetone extract of E. cinerea afforded three new (1-3) polyacetylenes, one rare monoterpenoid glycoside as verbenone-5-O-β-D-glycopyranoside (4) and one prenylated coumarin as osthol (5). The structures of all new compounds were elucidated using modern spectroscopic methods, including 2D NMR and mass analyses. The potency of the compounds to induce cell death was determined on SKNMC, PC3 and MCF-7 cell lines using MTT method in which compounds 1 and 2 showed moderate cytotoxic effects, especially against PC3 cells.
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- 2017
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46. Preparation of a reproducible long-acting formulation of risperidone-loaded PLGA microspheres using microfluidic method.
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Jafarifar E, Hajialyani M, Akbari M, Rahimi M, Shokoohinia Y, and Fattahi A
- Subjects
- Microfluidics, Risperidone, Glycols, Microspheres
- Abstract
The aim of the present study is to prepare risperidone-loaded poly lactic-co-glycolic acid (PLGA) microspheres within microfluidic system and to achieve a formulation with uniform size and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optimizing study was carried out at different processing parameters (e.g. PLGA and surfactant concentration and flow rates ratio of outer to inner phase). The computational fluid dynamic (CFD) modeling was performed, and loading and release study were carried out. CFD simulation indicates that increasing the flow rate of aqueous phase cause to decrease the droplet size, while the change in size of microspheres did not follow a specific pattern in the experimental results. The most uniform microspheres and narrowest standard deviation (66.79 μm ± 3.32) were achieved using T-junction chip, 1% polyvinylalcohol, 1% PLGA and flow rates ratio of 20. The microfluidic-assisted microspheres were more uniform with narrower size distribution. The release of risperidone from microspheres produced by the microfluidic method was more reproducible and closer to zero-order kinetic model. The release profile of formulation with 2:1 drug-to-polymer ratio was the most favorable release, in which 41.85% release could be achieved during 24 days.
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- 2017
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47. Protective effect of bioactive compounds from Echinophora cinerea against cisplatin-induced oxidative stress and apoptosis in the PC12 cell line.
- Author
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Shokoohinia Y, Khajouei S, Ahmadi F, Ghiasvand N, and Hosseinzadeh L
- Abstract
Objectives: The present study aims to evaluate the protective effect of the compounds isolated from Echinophora cinerea ( E. cinerea ) against oxidative stress and apoptosis induced by cisplatin (CIS) in PC12 cells., Materials and Methods: Six compounds were isolated as quercetrin-3- O - β -D-glucopyranoside (QUE), osthol (OST), verbenone-5- O - β -D-glycopyranoside (VER), Isoimperatorin (ISO), kaempferol-3- O - β -D-glucopyranoside (KAM), and echinophorin B (ECH). For this study, we used MTT reduction assay for detection of protective effects of isolated compounds on CIS-induced cytotoxicity in PC12 cells. The effects of isolated compounds against apoptosis induced by CIS were investigated through the measurement of mitochondrial membrane potential (MMP), Bax and Bcl2 mRNA expression, and caspase-3 activation. We also assessed oxidative stress by measuring reactive oxygen species (ROS) generation with 2', 7'-dichlorofluorescein diacetate (DCFH-DA)., Results: Treatment of cells with QUE and OST before exposure to the CIS increased cell viability, i.e., these compounds protected the cells against CIS -induced cytotoxicity. In addition, pre-treatment with QUE and OST decreased CIS-induced apoptosis through up-regulation of Bcl-2, inhibition of caspase-3 activity, and mitochondrial membrane potential (MMP) increase. OST decreased ROS generation induced by CIS, as well., Conclusion: Our in vitro experiment showed that QUE and OST are apoptotic inhibitors that effectively block CIS-induced neurotoxicity predicting their therapeutic potential in the prevention of chemotherapy-induced neurotoxicity.
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- 2017
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48. The Hydrogen Sulfide Releasing Molecule Acetyl Deacylasadisulfide Inhibits Metastatic Melanoma.
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De Cicco P, Panza E, Armogida C, Ercolano G, Taglialatela-Scafati O, Shokoohinia Y, Camerlingo R, Pirozzi G, Calderone V, Cirino G, and Ianaro A
- Abstract
Melanoma is the most common form of skin cancer. Given its high mortality, the interest in the search of preventive measures, such as dietary factors, is growing significantly. In this study we tested, in vitro and in vivo , the potential anti-cancer effect of the acetyl deacylasadisulfide (ADA), a vinyl disulfide compound, isolated and purified from asafoetida a foul-smelling oleo gum-resin of dietary and medicinal relevance. ADA markedly suppressed proliferation of human melanoma cell lines by inducing apoptosis. Moreover, treatment of melanoma cells with ADA reduced nuclear translocation and activation of NF-κB, decreased the expression of the anti-apoptotic proteins c-FLIP, XIAP, and Bcl-2 and inhibited the phosphorylation and activation of both AKT and ERK proteins, two of the most frequently deregulated pathways in melanoma. Finally, the results obtained in vitro were substantiated by the findings that ADA significantly and dose-dependently reduced lung metastatic foci formation in C57BL/6 mice. In conclusion, our findings suggest that ADA significantly inhibits melanoma progression in vivo and could represent an important lead compound for the development of new anti-metastatic agents.
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- 2017
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49. Ethanolic Extract of Berberis Vulgaris Fruits Inhibits the Proliferation of MCF-7 Breast Cancer Cell Line Through Induction of Apoptosis
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Ghafourian E, Sadeghifard N, Pakzad I, Valizadeh N, Maleki A, Jafari F, Ghiasvand N, Abdi J, Shokoohinia Y, and Ghafourian S
- Subjects
- 3T3 Cells, Animals, Antineoplastic Agents, Phytogenic toxicity, Breast Neoplasms drug therapy, Breast Neoplasms pathology, Down-Regulation, Female, Fruit, Gene Expression drug effects, Humans, MCF-7 Cells, Mice, Phytotherapy, Plant Extracts toxicity, Proto-Oncogene Proteins c-bcl-2 genetics, Tumor Suppressor Protein p53 genetics, Antineoplastic Agents, Phytogenic pharmacology, Apoptosis, Berberis, Cell Proliferation drug effects, Plant Extracts pharmacology
- Abstract
Background: As it is obvious, there is much documentation that shows the importance of breast cancer treatment in patients. High expressions of P53 and Bcl-2 are associated with breast cancer, which are reliable factors to follow up the breast cancer. Berberis vulgaris is used as a traditional medicine in cancer. Despite of the fact that many researches have demonstrated its anti-cancer properties, there are no scientific documents to show its efficacy in detail in breast cancer., Objective: Because of traditional use of B. vulgaris and little knowledge about its effects, our research was focused on determining the efficacy and toxicity of B. vulgaris. For this reason, we determined the efficacy of B. vulgaris on breast cancer cells., Method: As described in Method section, standard protocols including MTT assay and qPCR were performed to identify the effect of B. vulgaris ethanolic extract against breast cancer cells., Results: Our results clearly demonstrated that 35 mg/ml had IC50 against 3t3 normal cells, and 9 mg/ml of B. vulgaris was effective against MCF-7 breast cancer cells. The results demonstrated that even at only 1 mg/ml concentration of B. vulgaris, crude extract was effective, 9 mg/ml and 12 mg/ml of extract had better anti-cancer activity compared with doxorubicin., Conclusion: Despite that the role of anticancer properties of B. vulgaris was clearly defined in some patents, our results demonstrated the potency of B. vulgaris against breast cancer, but further analysis should be performed to candidate this herb as an anti-breast cancer drug., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2017
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50. Antileishmanial activity of prenylated coumarins isolated from Ferulago angulata and Prangos asperula.
- Author
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Sajjadi SE, Eskandarian AA, Shokoohinia Y, Yousefi HA, Mansourian M, Asgarian-Nasab H, and Mohseni N
- Abstract
Leishmaniasis has a wide spectrum of signs and symptoms due to infection to numbers of Leishmania species and makes enormous mortality and morbidity. There are clues of antileishmanial effects of prenylated coumarins. Apiaceae family is one of the most important sources of coumarins. Air-dried aerial parts of Ferulago angulata and fruits of Prangos asperula were extracted with n-hexane, using a soxhlet apparatus. The solvents were evaporated under reduced pressure. Column chromatography and crystallization process resulted to isolation of three prenylated coumarins. (1)H-nuclear magnetic resonance, electron ionization Mass and Infrared spectra were used for elucidation of isolated compounds. Leishmanicidal activity of isolated coumarins was assessed on Leishmania major strain (MRHO/IR/75/ER) for the first time. Suberosin epoxide and suberosin were isolated from aerial parts of F. angulata and osthol was extracted from grounded fruits of P. asperula. Osthol showed a significant antileishmanial effect on promastigotes in early hours of exposure with IC50 of 14.40 µg/mL but suberosin epoxide showed only a weak antileishmanial activity. IC50 of osthol and suberosin epoxide after 48 h were 10.79 and 54.0 µg/mL, respectively. Suberosin showed no remarkable effect in these concentrations. This is the first report on the pharmacological activity of suberosin epoxide. Substantial difference between efficacies of two isomers, osthol and suberosin remarks the importance of prenyl substituent location on C-8.
- Published
- 2016
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