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TRPA1 Modulating C 14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba .

Authors :
Chianese G
Sirignano C
Shokoohinia Y
Mohammadi Z
Bazvandi L
Jafari F
Jalilian F
Schiano Moriello A
De Petrocellis L
Taglialatela-Scafati O
Rigano D
Source :
Molecules (Basel, Switzerland) [Molecules] 2018 Jul 17; Vol. 23 (7). Date of Electronic Publication: 2018 Jul 17.
Publication Year :
2018

Abstract

Phytochemical investigation of the apolar extract obtained from aerial parts of the Iranian endemic plant Echinophora platyloba DC (Apiaceae) resulted in the characterization of the polyacetylene fraction of this plant. This resulted to be composed of the known echinophorins A and B, embedding the very rare α-pyrone terminal, and of the new echinophorin D ( 3 ), including also three conjugated triple bonds. The chemical structures of these compounds were secured by detailed inspection of MS and 1D/2D NMR spectra. The isolated polyacteylenes were evaluated for their modulation of six thermo-TRP channels and they revealed a selective activity on TRPA1, an ion channel involved in the mediation of neuropathic and inflammatory pain. This is the first report on the activity of plant polyacetylenes on transient receptor potential (TRP) channels.

Details

Language :
English
ISSN :
1420-3049
Volume :
23
Issue :
7
Database :
MEDLINE
Journal :
Molecules (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
30018233
Full Text :
https://doi.org/10.3390/molecules23071750