1. pSTAT1 is activated during the progression of IgA nephropathy
- Author
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Jianling Tao, Neeraja Kambham, Shirley Kwok, and Richard A. Lafayette
- Subjects
Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ABSTRACT Introduction: IgA nephropathy is the most common primary glomerular disease. Its pathogenesis is still poorly understood. Alterations of the JAK-STAT pathway may play an important role in IgA nephropathy. Methods: We evaluated the clinical features, pathology and tissue staining for lymphocytes and pSTAT1 in 43 patients with biopsy proven IgA nephropathy. They were followed to determine their disease outcomes. All had biopsy tissue and multiple laboratory measurements to assess their kidney disease progression. 16 patients underwent repeat kidney biopsy to further assess their clinical status. Results: Median eGFR at baseline was 61 ml/min/1.73m2 and median proteinuria was 2600 mg/d. Median follow up was 5 years with an average annual decline in eGFR of 2.25 ml/min/1.73m2. There was significant inflammation and atrophy seen in the first biopsy, which progressed among those who undertook a 2nd biopsy. Compared to healthy kidney tissue, glomeruli and tubulointerstitium demonstrated increased lymphocyte (CD3+) infiltrates and increased pSTAT1 staining by immunohistochemistry. Increased CD3 (p=0.001) staining and increased pSTAT1(p=0.03) correlated with reduced eGFR levels. In repeat biopsy samples, increasing pSTAT1 staining correlated with loss of eGFR over time (p=0.02). Conclusion: These findings support the hypothesis that pSTAT1 is activated in IgA nephropathy and may play a role in progression towards kidney failure.
- Published
- 2022
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