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Galectin-1–driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance
- Source :
- J Clin Invest
- Publication Year :
- 2019
- Publisher :
- American Society for Clinical Investigation, 2019.
-
Abstract
- Cancer immunotherapy and its budding effectiveness at improving patient outcomes has revitalized our hope to fight cancer in a logical and safe manner. Immunotherapeutic approaches to reengage the immune system have largely focused on reversing immune checkpoint inhibitor pathways, which suppress the antitumor response. Although these approaches have generated much excitement, they still lack absolute success. Interestingly, newly described host-tumor sugar chains (glycosylations) and glycosylation-binding proteins (lectins) play key roles in evading the immune system to determine cancer progression. In this issue of the JCI, Nambiar et al. used patient head and neck tumors and a mouse model system to investigate the role of galactose-binding lectin 1 (Gal1) in immunotherapy resistance. The authors demonstrated that Gal1 can affect immune checkpoint inhibitor therapy by increasing immune checkpoint molecules and immunosuppressive signaling in the tumor. Notably, these results suggest that targeting a tumor’s glycobiological state will improve treatment efficacy.
- Subjects :
- Adult
Male
0301 basic medicine
Firearms
Galectin 1
Galectins
medicine.medical_treatment
T cell
T-Lymphocytes
Programmed Cell Death 1 Receptor
B7-H1 Antigen
03 medical and health sciences
Mice
0302 clinical medicine
Immune system
Downregulation and upregulation
Immune Tolerance
Medicine
Animals
Humans
Endothelium
Aged
Aged, 80 and over
business.industry
General Medicine
Immunotherapy
Middle Aged
Blockade
Mice, Inbred C57BL
Radiation therapy
carbohydrates (lipids)
STAT1 Transcription Factor
030104 developmental biology
medicine.anatomical_structure
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Galectin-1
Commentary
T cell migration
Cancer research
Female
business
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J Clin Invest
- Accession number :
- edsair.doi.dedup.....10ae2195bd4106f7d6202d49886da83d